MCID: PRP080
MIFTS: 36

Peripheral Artery Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Peripheral Artery Disease

MalaCards integrated aliases for Peripheral Artery Disease:

Name: Peripheral Artery Disease 12 14
Peripheral Arterial Diseases 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050830

Summaries for Peripheral Artery Disease

Disease Ontology : 12 An artery disease that is characterized by build up of plaque in the arteries that carry blood to your head, organs, and limbs.

MalaCards based summary : Peripheral Artery Disease, also known as peripheral arterial diseases, is related to peripheral vascular disease and intermittent claudication, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Peripheral Artery Disease is CRP (C-Reactive Protein). The drugs Aspirin and Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include endothelial, heart and bone.

Wikipedia : 72 Peripheral artery disease (PAD) is a narrowing of the arteries other than those that supply the heart or... more...

Related Diseases for Peripheral Artery Disease

Graphical network of the top 20 diseases related to Peripheral Artery Disease:



Diseases related to Peripheral Artery Disease

Symptoms & Phenotypes for Peripheral Artery Disease

UMLS symptoms related to Peripheral Artery Disease:


angina pectoris, chest pain, edema

Drugs & Therapeutics for Peripheral Artery Disease

Drugs for Peripheral Artery Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 401)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-78-2 2244
2
Paclitaxel Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 33069-62-4 36314
3
Simvastatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 79902-63-9 54454
4
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
5
Metformin Approved Phase 4,Phase 3 657-24-9 14219 4091
6
Cilostazol Approved Phase 4,Phase 3,Phase 2,Phase 1 73963-72-1 2754
7
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3 2180-92-9, 38396-39-3 2474
8
Clonidine Approved Phase 4 4205-90-7 2803
9
Levobupivacaine Approved Phase 4 27262-47-1 92253
10
Morphine Approved, Investigational Phase 4 57-27-2 5288826
11
Amlodipine Approved Phase 4 88150-42-9 2162
12
Losartan Approved Phase 4,Early Phase 1 114798-26-4 3961
13
Methyltestosterone Approved Phase 4 58-18-4 6010
14
Testosterone Approved, Investigational Phase 4 58-22-0 6013
15
Nitric Oxide Approved Phase 4,Phase 2 10102-43-9 145068
16
Menthol Approved Phase 4,Phase 2,Phase 3 2216-51-5 16666
17
Alprostadil Approved, Investigational Phase 4,Phase 3,Phase 2 745-65-3 149351
18
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
19
Nebivolol Approved, Investigational Phase 4,Phase 3 152520-56-4, 99200-09-6, 118457-14-0 71301
20
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
21
Zinc Approved Phase 4,Phase 1 7440-66-6 32051 23994
22
Pravastatin Approved Phase 4,Phase 3,Phase 1 81093-37-0 54687
23
Allopurinol Approved Phase 4 315-30-0 2094
24
Ramipril Approved Phase 4 87333-19-5 5362129
25
Ezetimibe Approved Phase 4,Phase 3 163222-33-1 150311
26
Ticlopidine Approved Phase 4,Phase 3,Phase 2,Phase 1 55142-85-3 5472
27
Dalteparin Approved Phase 4 9005-49-6
28 Defibrotide Approved, Investigational Phase 4 83712-60-1
29
Heparin Approved, Investigational Phase 4,Phase 1,Phase 2 9005-49-6 772 46507594
30
Iloprost Approved, Investigational Phase 4,Phase 2 78919-13-8 6443959
31
Pentoxifylline Approved, Investigational Phase 4,Phase 3 6493-05-6 4740
32
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
33
Ticagrelor Approved Phase 4,Phase 3,Phase 2 274693-27-5 9871419
34
Adenosine Approved, Investigational Phase 4,Phase 3,Phase 2 58-61-7 60961
35
Methylnaltrexone Approved Phase 4 83387-25-1, 916055-93-1 6603824
36
Naltrexone Approved, Investigational, Vet_approved Phase 4 16590-41-3 5360515
37
Valsartan Approved, Investigational Phase 4,Phase 2 137862-53-4 60846
38
Glipizide Approved Phase 4 29094-61-9 3478
39
Thrombin Approved Phase 4,Phase 3
40
Vorapaxar Approved Phase 4,Phase 3 618385-01-6
41
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
42
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 158781 130881
43
Nicorandil Approved Phase 4 65141-46-0 47528
44
Tinzaparin Approved Phase 4 9005-49-6, 9041-08-1 25244225
45
Insulin Glargine Approved Phase 4 160337-95-1
46
Ranolazine Approved, Investigational Phase 4 142387-99-3, 95635-55-5 56959
47
Clopidogrel Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 120202-66-6, 113665-84-2 60606
48
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-30-3 6037
49
Niacin Approved, Investigational, Nutraceutical Phase 4,Phase 3,Phase 2 59-67-6 938
50
Nicotinamide Approved, Nutraceutical Phase 4,Phase 3,Phase 2 98-92-0 936

Interventional clinical trials:

(show top 50) (show all 1080)

id Name Status NCT ID Phase Drugs
1 Far Infrared Therapy on Peripheral Artery Disease in Hemodialysis Patients Unknown status NCT01095549 Phase 4
2 Residual Platelet Activity In Advanced Peripheral Artery Disease Unknown status NCT01627431 Phase 4 Acetylsalicylic acid;Clopidogrel
3 Efficacy Study of Stenting, Paclitaxel Eluting Balloon or Atherectomy to Treat Peripheral Artery Disease Unknown status NCT00986752 Phase 4
4 Effects of Nicotinic Acid Plus Simvastatin Versus Simvastatin Alone on Carotid and Femoral Intima-Media Thickness in Patients With Peripheral Artery Disease (NASCIT) Unknown status NCT00712049 Phase 4 simvastatin;Nicotinic Acid
5 Metformin, Muscle Energetics, and Vascular Function in Older Adults With Peripheral Artery Disease Unknown status NCT01901224 Phase 4 Metformin 1000 mg;Placebo
6 Multifactorial Intervention on Cardiovascular Risk Factors in Subjects With Peripheral Arterial Disease Unknown status NCT00144937 Phase 4 Stepwise therapy for dyslipidemia, hypertension and diabetes
7 A Multicenter, Therapeutic Used Study to Evaluate the Efficacy and Safety of Pletaal SR Capsule (Cilostazol) in Subjects With Peripheral Arterial Disease Symptom Due to Chronic Occlusive Arterial Disease Unknown status NCT01711333 Phase 4 Pletaal SR capsule
8 Drug Eluting Balloon in peripherAl inTErvention for Below-The-Knee Arteries With Freeway and Lutonix Unknown status NCT02279784 Phase 4
9 Paclitaxel-eluting Balloon Angioplasty With Provisional Use of Nitinol Stent Versus Systematic Implantation of Paclitaxel-eluting Stent for the Treatment of Femoropopliteal de Novo Lesions Unknown status NCT01969630 Phase 4
10 Paclitaxel Eluting Balloon and Conventional Balloon for In-Stent Restenosis of the Superficial Femoral Artery Unknown status NCT01083394 Phase 4
11 Efficacy of Self-Expanding Nitinol S.M.A.R.T CONTROL Stent Versus Life Stent For The Atherosclerotic Femoro-Popliteal Arterial Disease Unknown status NCT01653600 Phase 4
12 Platelets Induced Vasodilation, in Vitro and in Vivo Study Unknown status NCT00152646 Phase 4 placebo, aspirine, clopidogrel
13 Paclitaxel Eluting Stent or Exercise for Thigh Atherosclerosis Unknown status NCT02033135 Phase 4
14 Comparison of Stenting Versus Best Medical Therapy for Treatment of Ostial Renal Artery Stenosis: a Trial in Patients With Advanced Atherosclerosis Unknown status NCT00711984 Phase 4
15 Aspirin Resistance and Prognosis of Patients With Critical Limb Ischaemia Unknown status NCT01104441 Phase 4
16 Interest of a Bi-truncal Nerve Block (Femoral + Sciatic) Extended, Systematically Associated With General Anesthesia, in the Femoropopliteal Bypass: Study of Post-operative Analgesia and Peripheral Circulation Downstream Unknown status NCT01785693 Phase 4 levobupivacaine, clonidine
17 The Association Between Very Small Embryonic-like Stem Cells and the Prognosis of Coronary Artery Disease Patients Unknown status NCT01633359 Phase 4 Intensive statin;Routine statin
18 Hypertension Control Based on Home Blood Pressure Unknown status NCT00198562 Phase 4 Amlodipine, Losartan
19 Testosterone for Peripheral Vascular Disease Unknown status NCT00504712 Phase 4 Testosterone;0.9% saline
20 A Trial to Evaluate Efficacy of Heart-protecting Musk Pill Unknown status NCT01897805 Phase 4 Heart-protecting Musk Pill;Placebo
21 Study Effects of Ginkgo Biloba Extract on Endothelial Cell Function and Genetic Effects on the Response to Ginkgo Biloba Extract in Diabetic Patients With Stable Coronary Artery Disease Unknown status NCT01038050 Phase 4 Ginkgo Biloba Extract (GBE)
22 Comparison of Stent and Prothesis Bypass in Superficial Femoral Artery Unknown status NCT01147419 Phase 4
23 Long-term Pleiotropic Effect of Statins in Patients With Peripheral Arterial Disease Completed NCT01041729 Phase 4 Atorvastatin;Standard Medical Treatment
24 Prevention of Ischemic Events in Patients With Peripheral Arterial Disease Completed NCT00761969 Phase 4
25 Allopurinol as a Possible Oxygen Sparing Agent During Exercise in Peripheral Arterial Disease Completed NCT01147705 Phase 4 Allopurinol;Placebo
26 Angiotensin Converting Enzyme (ACE) Inhibition and Peripheral Arterial Disease Completed NCT00681226 Phase 4 Ramipril or matching placebo
27 Intermittent Mechanical Compression For Peripheral Arterial Disease Completed NCT00855673 Phase 4 Control
28 The Effects of Ramipril on Clinical Symptoms in Patients With Peripheral Arterial Disease Completed NCT00168467 Phase 4 Ramipril
29 Effectiveness of Intensive Lipid Modification Medication in Preventing the Progression of Peripheral Arterial Disease (The ELIMIT Study) Completed NCT00687076 Phase 4 Ezetimibe;Niaspan;Statin therapy;Aspirin;Clopidogrel;Placebo Niaspan;Placebo Ezetimibe
30 The Effects of Physical Training, ASA (Aspirin), and Clopidogrel on the Walking Capacity of Patients With Stage II Peripheral Arterial Disease (PAD) Completed NCT00189618 Phase 4 Aspirin;Clopidogrel
31 The Jetstream G3™ Calcium Study Completed NCT01273623 Phase 4
32 The Safety and Efficacy of Cilostazol in Ischemic Stroke Patients With Peripheral Arterial Disease (SPAD Study) Completed NCT01188824 Phase 4 Cilostazol
33 Efficacy Evaluation of Dotarem Compared to Gadovist in the Diagnosis of Peripheral Arterial Disease Completed NCT01026389 Phase 4 Dotarem;Gadovist
34 Evaluation of Cilostazol in Combination With L-Carnitine Completed NCT00822172 Phase 4 cilostazol
35 Angioplasty in Peripheral Arterial Disease and Endothelial Function Completed NCT00660634 Phase 4
36 The Jetstream (JET) Post-market Registry Completed NCT01436435 Phase 4
37 Arterial Inflow and Muscle Ischemia During Calf Stimulation With the Veinoplus Device Completed NCT01592812 Phase 4
38 Paclitaxel-coated Balloons in Femoral Indication to Defeat Restenosis Completed NCT01083030 Phase 4
39 Drug Eluting Balloon in peripherAl inTErvention SFA Completed NCT01556542 Phase 4
40 NanoCross BTK, a Prospective, Non-randomized, Multicenter, Controlled Trial Evaluating the Performance of the NanoCrossTM .014 Balloon Catheter in Infrapopliteal Lesions Completed NCT01783600 Phase 4
41 DOTAREM®-Enhanced MRA Compared to GADOVIST®-Enhanced MRA in Patients With Abdominal or Lower Limb Arterial Diseases Completed NCT00955617 Phase 4
42 Protective Effect of EPA on Cardiovascular Events Completed NCT00231738 Phase 4 Eicosapentaenoic acid ethyl ester(EPADEL Capsule 300 TM)
43 A Study to Collect Intravascular Ultrasound Images Before and After Treatment With the Jetstream System Completed NCT00911417 Phase 4
44 Effect of Cilostazol Endothelial Progenitor Cells and Collateral Formation in Peripheral Occlusive Artery Disease (PAOD) Completed NCT01952756 Phase 4 Cilostazol;Dummy Placebo
45 Study of SilverHawk®/TurboHawk® in Lower Extremity Vessels (DEFINITIVE™ LE) Completed NCT00883246 Phase 4
46 BeSmooth Study, Investigating the BeSmooth Peripheral Stent System for the Treatment of Iliac Lesions Completed NCT02690051 Phase 4
47 Comparing Angioplasty and DES in the Treatment of Subjects With Ischemic Infrapopliteal Arterial Disease Completed NCT00640770 Phase 4
48 EverFlex™ Self-expanding Peripheral Stent With Entrust™ Delivery System Clinical Study Completed NCT02066740 Phase 4
49 DURABILITY+ : a Prospective, Multi-center, Controlled Study With the Everflex+ Stent in SFA Lesions Completed NCT01412463 Phase 4
50 Efficacity Study With the Protégé EverFlex Stent in Popliteal Lesions Completed NCT01412450 Phase 4

Search NIH Clinical Center for Peripheral Artery Disease

Genetic Tests for Peripheral Artery Disease

Anatomical Context for Peripheral Artery Disease

MalaCards organs/tissues related to Peripheral Artery Disease:

39
Endothelial, Heart, Bone, Bone Marrow, Skin, Testes, Brain

Publications for Peripheral Artery Disease

Articles related to Peripheral Artery Disease:

(show top 50) (show all 558)
id Title Authors Year
1
The Effect of Structured Patient Education on Physical Activity in Patients with Peripheral Arterial Disease and Intermittent Claudication: A Systematic Review. ( 28528678 )
2017
2
Crural Index and extensive atherosclerosis of crural vessels are associated with long-term cardiovascular mortality in patients with symptomatic peripheral artery disease. ( 28763728 )
2017
3
Association of arterial calcification with chronic limb ischemia in patients with peripheral artery disease. ( 28870682 )
2017
4
Peripheral Artery Disease: To Screen or Not Screen, That Is the Question! ( 28868916 )
2017
5
Ticagrelor versus Clopidogrel in Symptomatic Peripheral Artery Disease. ( 27959717 )
2017
6
Growth Differentiation Factor 15 Is Associated With Major Amputation and Mortality in Patients With Peripheral Artery Disease. ( 28855167 )
2017
7
Re: The Survival Benefit of Kidney Transplantation in the Setting of Combined Peripheral Arterial Disease and End-Stage Renal Failure. ( 28208552 )
2017
8
Endothelial Cell Inflammation and Antioxidant Capacity are Associated With 6-Minute Walk Performance in Patients With Symptomatic Peripheral Artery Disease. ( 28835113 )
2017
9
The Relationship Between Peripheral Artery Disease Symptomatology and Ischemia. ( 28858146 )
2017
10
Electronegative low-density lipoprotein increases the risk of ischemic lower-extremity peripheral artery disease in uremia patients on maintenance hemodialysis. ( 28680087 )
2017
11
Aspirin Monotherapy Should Not Be Recommended for Cardioprotection in Patients With Symptomatic Peripheral Artery Disease. ( 28847795 )
2017
12
Advances in Percutaneous Therapies for Peripheral Artery Disease: Drug-Coated Balloons. ( 28840466 )
2017
13
Blood Pressure and Leg Deoxygenation are Exaggerated During Treadmill Walking in Patients with Peripheral Artery Disease. ( 28819005 )
2017
14
Upper Extremity Medial Arterial Calcification and Peripheral Artery Disease in Asymptomatic Patients With Chronic Kidney Disease in Predialysis Stage. ( 28823179 )
2017
15
Acute and chronic effects of exercise on mRNA expression in the skeletal muscle of two mouse models of peripheral artery disease. ( 28771574 )
2017
16
Dietary intake and peripheral arterial disease incidence in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study. ( 28077376 )
2017
17
Pattern and distribution of peripheral arterial disease in diabetic patients with critical limb ischemia (rutherford clinical category 4-6). ( 28876565 )
2017
18
Baseline assessment and comparison of arterial anatomy, hyperemic flow, and skeletal muscle perfusion in peripheral artery disease: The Cardiovascular Cell Therapy Research Network "Patients with Intermittent Claudication Injected with ALDH Bright Cells" (CCTRN PACE) study. ( 27979038 )
2017
19
Socioeconomic Status and Incidence of Hospitalization With Lower-Extremity Peripheral Artery Disease: Atherosclerosis Risk in Communities Study. ( 28862929 )
2017
20
Review of aspirin and clopidogrel resistance in peripheral arterial disease. ( 28893489 )
2017
21
Motivators and Barriers to Walking in Older Adults With Peripheral Artery Disease. ( 28895972 )
2017
22
Long-term cardiovascular outcome, use of resources, and healthcare costs in patients with peripheral artery disease: Results from a nationwide Swedish study. ( 28950310 )
2017
23
Hidradenitis Suppurativa is Associated with Myocardial Infarction, but Not Stroke or Peripheral Arterial Disease of Lower Extremities. ( 28914960 )
2017
24
Disruption of mitochondrial quality control in peripheral artery disease: New therapeutic opportunities. ( 27876411 )
2017
25
Noninvasive Peripheral Artery Disease Screening Tools: A Deficient Knowledge among French Vascular Residents from 4 Medical Schools. ( 28887241 )
2017
26
Re: "Systematic Review and Meta-analysis of the Association between C-reactive Protein and Major Cardiovascular Events in Patients with Peripheral Artery Disease: Do Not Ignore Patients with Critical Limb Ischaemia". ( 28882514 )
2017
27
Sudomotor function in diabetic peripheral artery disease: a role for diabetic neuropathy? ( 28914379 )
2017
28
Serum high mobility group box-1 and osteoprotegerin levels are associated with peripheral arterial disease and critical limb ischemia in type 2 diabetic subjects. ( 28789654 )
2017
29
Exercise Oximetry and Exercise Near-infrared Spectroscopy to Assess Peripheral Artery Disease. ( 28076013 )
2017
30
Peripheral Artery Disease in Patients with Chronic Obstructive Pulmonary Disease. ( 28084818 )
2017
31
Ischaemic stroke and peripheral artery disease. ( 28839294 )
2017
32
The efficacy of transcutaneous electrical nerve stimulation on the improvement of walking distance in patients with peripheral arterial disease with intermittent claudication: study protocol for a randomised controlled trial: the TENS-PAD study. ( 28797281 )
2017
33
2016 American College of Cardiology/American Heart Association Guideline on the Management of Patients With Lower Extremity Peripheral Artery Disease: Perioperative Implications. ( 28826846 )
2017
34
Drug-eluting stenting for femoropopliteal lesions, followed by cilostazol treatment, reduces stent restenosis in patients with symptomatic peripheral artery disease. ( 28073668 )
2017
35
Inflammatory Cytokine Levels After Endovascular Therapy in Patients With Peripheral Artery Disease. ( 27932554 )
2016
36
Endothelial interleukin-21 receptor up-regulation in peripheral artery disease. ( 26705256 )
2016
37
A systematic review of the sensitivity and specificity of the toe-brachial index for detecting peripheral artery disease. ( 27165712 )
2016
38
Association of chronic obstructive pulmonary, coronary artery, or peripheral artery disease with abdominal aortic aneurysm rupture. ( 27606806 )
2016
39
Correlation of ankle-brachial index and peripheral artery disease with the status of body fat deposition and metabolic syndrome in asymptomatic premenopausal women. ( 27634331 )
2016
40
Design and rationale for the Effects of Ticagrelor and Clopidogrel in Patients with Peripheral Artery Disease (EUCLID) trial. ( 27179727 )
2016
41
Optimal blood pressure in patients with peripheral artery disease following endovascular therapy. ( 26440772 )
2016
42
Influence of exercise training on proangiogenic TIE-2 monocytes and circulating angiogenic cells in patients with peripheral arterial disease. ( 26830098 )
2016
43
Predictors of new-onset peripheral artery disease Comment on Krause et al., p. 403 - 410. ( 27594390 )
2016
44
The Prognostic Value of Peripheral Artery Disease in Heart Failure: Insights from a meta-analysis. ( 27161297 )
2016
45
Contemporary cardiovascular risk and secondary preventive drug treatment patterns in peripheral artery disease patients undergoing revascularization. ( 27209402 )
2016
46
Plasma heme oxygenase-1 is decreased in peripheral artery disease patients. ( 27572090 )
2016
47
Renal Artery Stenosis in Patients with Peripheral Artery Disease: Prevalence, Risk Factors and Long-term Prognosis. ( 27919610 )
2016
48
Walking Capacity Is Positively Related with Heart Rate Variability in Symptomatic Peripheral Artery Disease. ( 27161329 )
2016
49
Differences in galectin-3, a biomarker of fibrosis, between participants with peripheral artery disease and participants with normal ankle-brachial index. ( 27155290 )
2016
50
Medical Therapy in Peripheral Artery Disease and Critical Limb Ischemia. ( 27181397 )
2016

Variations for Peripheral Artery Disease

Expression for Peripheral Artery Disease

Search GEO for disease gene expression data for Peripheral Artery Disease.

Pathways for Peripheral Artery Disease

GO Terms for Peripheral Artery Disease

Sources for Peripheral Artery Disease

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16 ExPASy
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34 ICD10 via Orphanet
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70 UMLS via Orphanet
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