MCID: PRP080
MIFTS: 54

Peripheral Artery Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Peripheral Artery Disease

MalaCards integrated aliases for Peripheral Artery Disease:

Name: Peripheral Artery Disease 12 14
Peripheral Arterial Diseases 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050830
UMLS 69 C1704436

Summaries for Peripheral Artery Disease

Disease Ontology : 12 An artery disease that is characterized by build up of plaque in the arteries that carry blood to your head, organs, and limbs.

MalaCards based summary : Peripheral Artery Disease, also known as peripheral arterial diseases, is related to critical limb ischemia and peripheral vascular disease, and has symptoms including edema, chest pain and angina pectoris. An important gene associated with Peripheral Artery Disease is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways. The drugs Aspirin and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and bone, and related phenotypes are Decreased free cholesterol and cardiovascular system

Wikipedia : 72 Peripheral artery disease (PAD) is a narrowing of the arteries other than those that supply the heart or... more...

Related Diseases for Peripheral Artery Disease

Diseases related to Peripheral Artery Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 189)
# Related Disease Score Top Affiliating Genes
1 critical limb ischemia 32.4 IL6 VEGFA
2 peripheral vascular disease 31.5 ACE APOB CRP IL6 SELP VCAM1
3 diabetic foot ulcers 30.4 CRP IL6
4 intermittent claudication 30.3 ACE CRP IL6 SELP VEGFA
5 limb ischemia 30.1 ACE IL6 NOS3 VEGFA
6 ischemia 30.1 ACE NOS3 SELP VEGFA
7 cardiogenic shock 29.9 CRP IL6
8 diabetes mellitus 29.9 ACE CRP IL6 VEGFA
9 coronary heart disease 1 29.8 ACE APOB CRP PCSK9
10 end stage renal failure 29.7 ACE CRP CST3 IL6
11 venous insufficiency 29.6 CRP SELP VCAM1
12 aortic valve disease 2 29.6 ACE CRP TNFRSF11B
13 arteriosclerosis obliterans 29.5 IL6 SELP VCAM1
14 periodontal disease 29.5 CRP IL6 TNFRSF11B
15 temporal arteritis 29.4 CCL2 CRP IL6
16 systolic heart failure 29.4 ACE CRP CST3 IL6
17 carotid artery disease 29.3 ACE APOB CCL2 CRP
18 carotid stenosis 29.3 ACE CRP SELP TNFRSF11B
19 chronic kidney failure 29.2 ACE CRP CST3 IL6 VCAM1
20 pneumonia 29.2 CCL2 CRP IL6
21 hypercholesterolemia, familial 29.2 APOB CRP PCSK9
22 atherosclerosis susceptibility 29.1 ACE APOB CCL2 CRP IL6 NOS3
23 heart disease 29.1 ACE APOB CRP CST3 IL6 NOS3
24 coronary artery anomaly 29.1 ACE APOB CRP IL6 NOS3 P2RY12
25 cerebrovascular disease 28.9 ACE APOB CRP IL6 SELP VCAM1
26 microvascular complications of diabetes 5 28.8 ACE NOS3 VCAM1 VEGFA
27 periodontitis 28.7 CCL2 CRP IL6 TNFRSF11B
28 microvascular complications of diabetes 1 28.7 CCL2 VCAM1 VEGFA
29 aortic aneurysm, familial abdominal, 1 28.7 ACE CCL2 CRP CST3 IL6 TNFRSF11B
30 stroke, ischemic 28.6 ACE APOB CRP NOS3 P2RY12 SELP
31 arteries, anomalies of 28.3 ACE APOB CCL2 CRP IL6 NOS3
32 systemic lupus erythematosus 28.2 CCL2 CRP IL6 NLRP1 VCAM1
33 arteriosclerosis 27.8 ACE APOB CCL2 CRP IL6 SELP
34 myocardial infarction 27.1 ACE APOB CCL2 CRP CST3 IL6
35 vascular disease 26.5 ACE APOB CCL2 CRP CST3 NOS3
36 cold agglutinin disease 10.5 CRP IL6
37 cryopyrin-associated periodic syndrome 10.5 CRP IL6
38 neutrophilia, hereditary 10.5 CRP IL6
39 acute cholangitis 10.4 CRP IL6
40 uremic pruritus 10.4 CRP IL6
41 castleman disease 10.4 CRP IL6
42 angina pectoris 10.4 ACE CRP IL6
43 prediabetes syndrome 10.3 APOB CRP IL6
44 generalized atherosclerosis 10.3 ACE CRP SELP
45 osteoporotic fracture 10.3 IL6 TNFRSF11B
46 lipid metabolism disorder 10.3 ACE APOB CRP
47 immune system disease 10.3 ACE CRP IL6
48 periodontitis, chronic 10.3 IL6 TNFRSF11B
49 platelet membrane fluidity 10.3 NOS3 SELP
50 spinal disease 10.3 CRP IL6 VEGFA

Graphical network of the top 20 diseases related to Peripheral Artery Disease:



Diseases related to Peripheral Artery Disease

Symptoms & Phenotypes for Peripheral Artery Disease

UMLS symptoms related to Peripheral Artery Disease:


edema, chest pain, angina pectoris

GenomeRNAi Phenotypes related to Peripheral Artery Disease according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 8.8 APOB PCSK9 SELP

MGI Mouse Phenotypes related to Peripheral Artery Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.02 NOS3 ACE SELP APOB TNFRSF11B CRP
2 homeostasis/metabolism MP:0005376 9.93 NLRP1 NOS3 P2RY12 ACE PCSK9 SELP
3 hematopoietic system MP:0005397 9.91 NLRP1 NOS3 P2RY12 ACE SELP TNFRSF11B
4 immune system MP:0005387 9.7 NLRP1 NOS3 ACE SELP APOB TNFRSF11B
5 liver/biliary system MP:0005370 9.17 NOS3 PCSK9 ACE SELP APOB IL6

Drugs & Therapeutics for Peripheral Artery Disease

Drugs for Peripheral Artery Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 391)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-78-2 2244
2
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Early Phase 1 120202-66-6, 113665-84-2 60606
3
Angiotensin II Approved, Investigational Phase 4,Phase 2,Early Phase 1 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
4
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 158781 130881
5
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
6
Metformin Approved Phase 4,Phase 3 657-24-9 4091 14219
7
Simvastatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 79902-63-9 54454
8
Paclitaxel Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 33069-62-4 36314
9
Cilostazol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 73963-72-1 2754
10
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3 38396-39-3, 2180-92-9 2474
11
Clonidine Approved Phase 4 4205-90-7 2803
12
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
13
Morphine Approved, Investigational Phase 4 57-27-2 5288826
14
Amlodipine Approved Phase 4 88150-42-9 2162
15
Losartan Approved Phase 4,Early Phase 1 114798-26-4 3961
16
Methyltestosterone Approved Phase 4 58-18-4 6010
17
Testosterone Approved, Investigational Phase 4 58-22-0 6013
18
Nitric Oxide Approved Phase 4,Phase 2 10102-43-9 145068
19
Menthol Approved Phase 4,Phase 2,Phase 3 2216-51-5 16666
20
Alprostadil Approved, Investigational Phase 4,Phase 3,Phase 2 745-65-3 149351
21
Pravastatin Approved Phase 4,Phase 3,Phase 1 81093-37-0 54687
22
Allopurinol Approved Phase 4 315-30-0 2094
23
Ramipril Approved Phase 4 87333-19-5 5362129
24
Ezetimibe Approved Phase 4,Phase 3 163222-33-1 150311
25
Ticlopidine Approved Phase 4,Phase 3,Phase 2 55142-85-3 5472
26
Dalteparin Approved Phase 4 9005-49-6
27 Defibrotide Approved, Investigational Phase 4 83712-60-1
28
Heparin Approved, Investigational Phase 4,Phase 1,Phase 2 9005-49-6 46507594 772
29
Iloprost Approved, Investigational Phase 4,Phase 2 78919-13-8 6443959
30
Pentoxifylline Approved, Investigational Phase 4,Phase 3 6493-05-6 4740
31
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
32
Thrombin Approved, Investigational Phase 4,Phase 3
33
Vorapaxar Approved Phase 4,Phase 3 618385-01-6
34
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
35
Ticagrelor Approved Phase 4,Phase 3,Phase 2 274693-27-5 9871419
36
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
37
Zinc Approved, Investigational Phase 4,Phase 1 7440-66-6 32051 23994
38
Nicorandil Approved, Investigational Phase 4 65141-46-0 47528
39
Adenosine Approved, Investigational Phase 4,Phase 2 58-61-7 60961
40
Insulin Glargine Approved Phase 4 160337-95-1
41
Ranolazine Approved, Investigational Phase 4 95635-55-5, 142387-99-3 56959
42 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
43
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-30-3 6037
44
Niacin Approved, Investigational, Nutraceutical Phase 4,Phase 3,Phase 2 59-67-6 938
45
Nicotinamide Approved, Investigational, Nutraceutical Phase 4,Phase 3,Phase 2 98-92-0 936
46 Tocopherol Approved, Investigational, Nutraceutical Phase 4,Phase 3
47
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-02-9 14985
48
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 10883523 5280795 6221
49
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
50
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2

Interventional clinical trials:

(show top 50) (show all 1021)

# Name Status NCT ID Phase Drugs
1 Far Infrared Therapy on Peripheral Artery Disease in Hemodialysis Patients Unknown status NCT01095549 Phase 4
2 Residual Platelet Activity In Advanced Peripheral Artery Disease Unknown status NCT01627431 Phase 4 Acetylsalicylic acid;Clopidogrel
3 Effect of olmesaRtan on Walking distancE and quaLIty of lifE in Peripheral Artery Disease Patients With Hypertension Treated For Intermittent Claudication (RELIEF) Unknown status NCT02373462 Phase 4 Olmesartan;other anti-hypertensive drug
4 Metformin, Muscle Energetics, and Vascular Function in Older Adults With Peripheral Artery Disease Unknown status NCT01901224 Phase 4 Metformin 1000 mg;Placebo
5 Effects of Nicotinic Acid Plus Simvastatin Versus Simvastatin Alone on Carotid and Femoral Intima-Media Thickness in Patients With Peripheral Artery Disease (NASCIT) Unknown status NCT00712049 Phase 4 simvastatin;Nicotinic Acid
6 Efficacy Study of Stenting, Paclitaxel Eluting Balloon or Atherectomy to Treat Peripheral Artery Disease Unknown status NCT00986752 Phase 4
7 Multifactorial Intervention on Cardiovascular Risk Factors in Subjects With Peripheral Arterial Disease Unknown status NCT00144937 Phase 4 Stepwise therapy for dyslipidemia, hypertension and diabetes
8 Drug Eluting Balloon in peripherAl inTErvention for Below-The-Knee Arteries With Freeway and Lutonix Unknown status NCT02279784 Phase 4
9 Paclitaxel-eluting Balloon Angioplasty With Provisional Use of Nitinol Stent Versus Systematic Implantation of Paclitaxel-eluting Stent for the Treatment of Femoropopliteal de Novo Lesions Unknown status NCT01969630 Phase 4
10 A Multicenter, Therapeutic Used Study to Evaluate the Efficacy and Safety of Pletaal SR Capsule (Cilostazol) in Subjects With Peripheral Arterial Disease Symptom Due to Chronic Occlusive Arterial Disease Unknown status NCT01711333 Phase 4 Pletaal SR capsule
11 Paclitaxel Eluting Balloon and Conventional Balloon for In-Stent Restenosis of the Superficial Femoral Artery Unknown status NCT01083394 Phase 4
12 Efficacy of Self-Expanding Nitinol S.M.A.R.T CONTROL Stent Versus Life Stent For The Atherosclerotic Femoro-Popliteal Arterial Disease Unknown status NCT01653600 Phase 4
13 Platelets Induced Vasodilation, in Vitro and in Vivo Study Unknown status NCT00152646 Phase 4 placebo, aspirine, clopidogrel
14 Paclitaxel Eluting Stent or Exercise for Thigh Atherosclerosis Unknown status NCT02033135 Phase 4
15 Comparison of Stenting Versus Best Medical Therapy for Treatment of Ostial Renal Artery Stenosis: a Trial in Patients With Advanced Atherosclerosis Unknown status NCT00711984 Phase 4
16 Aspirin Resistance and Prognosis of Patients With Critical Limb Ischaemia Unknown status NCT01104441 Phase 4
17 Prevena Vascular Groin Wound Study Unknown status NCT02581904 Phase 4
18 Interest of a Bi-truncal Nerve Block (Femoral + Sciatic) Extended, Systematically Associated With General Anesthesia, in the Femoropopliteal Bypass: Study of Post-operative Analgesia and Peripheral Circulation Downstream Unknown status NCT01785693 Phase 4 levobupivacaine, clonidine
19 Hypertension Control Based on Home Blood Pressure Unknown status NCT00198562 Phase 4 Amlodipine, Losartan
20 Testosterone for Peripheral Vascular Disease Unknown status NCT00504712 Phase 4 Testosterone;0.9% saline
21 Long-term Pleiotropic Effect of Statins in Patients With Peripheral Arterial Disease Completed NCT01041729 Phase 4 Atorvastatin;Standard Medical Treatment
22 Prevention of Ischemic Events in Patients With Peripheral Arterial Disease Completed NCT00761969 Phase 4
23 Allopurinol as a Possible Oxygen Sparing Agent During Exercise in Peripheral Arterial Disease Completed NCT01147705 Phase 4 Allopurinol;Placebo
24 Angiotensin Converting Enzyme (ACE) Inhibition and Peripheral Arterial Disease Completed NCT00681226 Phase 4 Ramipril or matching placebo
25 Intermittent Mechanical Compression For Peripheral Arterial Disease Completed NCT00855673 Phase 4 Control
26 Effectiveness of Intensive Lipid Modification Medication in Preventing the Progression of Peripheral Arterial Disease (The ELIMIT Study) Completed NCT00687076 Phase 4 Ezetimibe;Niaspan;Statin therapy;Aspirin;Clopidogrel;Placebo Niaspan;Placebo Ezetimibe
27 The Effects of Ramipril on Clinical Symptoms in Patients With Peripheral Arterial Disease Completed NCT00168467 Phase 4 Ramipril
28 The Effects of Physical Training, ASA (Aspirin), and Clopidogrel on the Walking Capacity of Patients With Stage II Peripheral Arterial Disease (PAD) Completed NCT00189618 Phase 4 Aspirin;Clopidogrel
29 The Jetstream G3™ Calcium Study Completed NCT01273623 Phase 4
30 The Safety and Efficacy of Cilostazol in Ischemic Stroke Patients With Peripheral Arterial Disease (SPAD Study) Completed NCT01188824 Phase 4 Cilostazol
31 Efficacy Evaluation of Dotarem Compared to Gadovist in the Diagnosis of Peripheral Arterial Disease Completed NCT01026389 Phase 4 Dotarem;Gadovist
32 Evaluation of Cilostazol in Combination With L-Carnitine Completed NCT00822172 Phase 4 cilostazol
33 Angioplasty in Peripheral Arterial Disease and Endothelial Function Completed NCT00660634 Phase 4
34 The Jetstream (JET) Post-market Registry Completed NCT01436435 Phase 4
35 Arterial Inflow and Muscle Ischemia During Calf Stimulation With the Veinoplus Device Completed NCT01592812 Phase 4
36 Paclitaxel-coated Balloons in Femoral Indication to Defeat Restenosis Completed NCT01083030 Phase 4
37 NanoCross BTK, a Prospective, Non-randomized, Multicenter, Controlled Trial Evaluating the Performance of the NanoCrossTM .014 Balloon Catheter in Infrapopliteal Lesions Completed NCT01783600 Phase 4
38 Drug Eluting Balloon in peripherAl inTErvention SFA Completed NCT01556542 Phase 4
39 DOTAREM®-Enhanced MRA Compared to GADOVIST®-Enhanced MRA in Patients With Abdominal or Lower Limb Arterial Diseases Completed NCT00955617 Phase 4
40 A Study to Collect Intravascular Ultrasound Images Before and After Treatment With the Jetstream System Completed NCT00911417 Phase 4
41 Protective Effect of EPA on Cardiovascular Events Completed NCT00231738 Phase 4 Eicosapentaenoic acid ethyl ester(EPADEL Capsule 300 TM)
42 Effect of Cilostazol Endothelial Progenitor Cells and Collateral Formation in Peripheral Occlusive Artery Disease (PAOD) Completed NCT01952756 Phase 4 Cilostazol;Dummy Placebo
43 Study of SilverHawk®/TurboHawk® in Lower Extremity Vessels (DEFINITIVE™ LE) Completed NCT00883246 Phase 4
44 BeSmooth Study, Investigating the BeSmooth Peripheral Stent System for the Treatment of Iliac Lesions Completed NCT02690051 Phase 4
45 EverFlex™ Self-expanding Peripheral Stent With Entrust™ Delivery System Clinical Study Completed NCT02066740 Phase 4
46 DURABILITY+ : a Prospective, Multi-center, Controlled Study With the Everflex+ Stent in SFA Lesions Completed NCT01412463 Phase 4
47 Efficacity Study With the Protégé EverFlex Stent in Popliteal Lesions Completed NCT01412450 Phase 4
48 Effect of Plavix on NO (Nitrogen Monoxide) Production of the Endothelial Function Completed NCT00648453 Phase 4 Clopidogrel (Plavix)
49 Comparing Angioplasty and DES in the Treatment of Subjects With Ischemic Infrapopliteal Arterial Disease Completed NCT00640770 Phase 4
50 Optimization of Treatment in Patients With Severe Peripheral Ischemia (Fontaine Stage IIb) Completed NCT01718288 Phase 4 iloprost;Standard Treatment (aspirin.....),

Search NIH Clinical Center for Peripheral Artery Disease

Genetic Tests for Peripheral Artery Disease

Anatomical Context for Peripheral Artery Disease

MalaCards organs/tissues related to Peripheral Artery Disease:

38
Heart, Endothelial, Bone, Bone Marrow, Skin, Testes, Brain

Publications for Peripheral Artery Disease

Articles related to Peripheral Artery Disease:

(show top 50) (show all 582)
# Title Authors Year
1
Protecting Life and Limb in Peripheral Artery Disease. ( 29358343 )
2018
2
Peripheral Artery Disease and Continuous Flow Left Ventricle Assist Device: An Engaging Complement Analysis May Help to Guide Treatment. ( 29436002 )
2018
3
Antithrombotic therapy in peripheral artery disease: A review of the EUCLID trial results and current ongoing trials. ( 29355992 )
2018
4
Lipid-lowering treatment in peripheral artery disease. ( 29413998 )
2018
5
Low Plasma Levels of Fibroblast Growth Factor-21 in Patients with Peripheral Artery Disease. ( 29367522 )
2018
6
Diagnostic accuracy of the postexercise ankle-brachial index for detecting peripheral artery disease in suspected claudicants with and without diabetes. ( 29432708 )
2018
7
Impact of peripheral artery disease on early and late outcomes of transcatheter aortic valve implantation in patients with severe aortic valve stenosis. ( 29425561 )
2018
8
Peripheral artery disease. ( 29419394 )
2018
9
Race and Socioeconomic Status Independently Affect Risk of Major Amputation in Peripheral Artery Disease. ( 29330260 )
2018
10
Peripheral artery disease is associated with frailty in chronic hemodialysis patients. ( 29402196 )
2018
11
PCSK9 inhibition for LDL lowering and beyond - implications for patients with peripheral artery disease. ( 29412075 )
2018
12
Peripheral artery disease and transcatheter aortic valve implantation: The tip of the atherosclerotic iceberg. ( 29425563 )
2018
13
Increased Risk of Peripheral Arterial Disease in Patients With Abdominal Aortic Aneurysm: A Retrospective Cohort Study (Version 5). ( 29444589 )
2018
14
Time trends in peripheral artery disease incidence, prevalence and secondary preventive therapy: a cohort study in The Health Improvement Network in the UK. ( 29358428 )
2018
15
Dual Anticoagulant and Antiplatelet Therapy for Coronary Artery Disease and Peripheral Artery Disease Patients. ( 29449336 )
2018
16
Effect of cilostazol on platelet reactivity among patients with peripheral artery disease on clopidogrel therapy. ( 29408797 )
2018
17
Cost-effectiveness analysis of asymptomatic peripheral artery disease screening with the ABI test. ( 29345540 )
2018
18
Toe-brachial index and exercise test can improve the exploration of peripheral artery disease. ( 29366987 )
2018
19
Improvement of bilateral lower-limb muscle oxygenation by low-density lipoprotein apheresis in a patient with peripheral artery disease undergoing hemodialysis. ( 29422296 )
2018
20
Drug-eluting stenting for femoropopliteal lesions, followed by cilostazol treatment, reduces stent restenosis in patients with symptomatic peripheral artery disease. ( 28073668 )
2017
21
Hidradenitis Suppurativa is Associated with Myocardial Infarction, but Not Stroke or Peripheral Arterial Disease of Lower Extremities. ( 28914960 )
2017
22
The efficacy of transcutaneous electrical nerve stimulation on the improvement of walking distance in patients with peripheral arterial disease with intermittent claudication: study protocol for a randomised controlled trial: the TENS-PAD study. ( 28797281 )
2017
23
2016 American College of Cardiology/American Heart Association Guideline on the Management of Patients With Lower Extremity Peripheral Artery Disease: Perioperative Implications. ( 28826846 )
2017
24
Growth Differentiation Factor 15 Is Associated With Major Amputation and Mortality in Patients With Peripheral Artery Disease. ( 28855167 )
2017
25
Acute and chronic effects of exercise on mRNA expression in the skeletal muscle of two mouse models of peripheral artery disease. ( 28771574 )
2017
26
Therapeutic Angiogenesis for Peripheral Artery Disease: Lessons Learned in Translational Science. ( 29430558 )
2017
27
The Relationship Between Peripheral Artery Disease Symptomatology and Ischemia. ( 28858146 )
2017
28
Advances in Percutaneous Therapies for Peripheral Artery Disease: Drug-Coated Balloons. ( 28840466 )
2017
29
Aspirin Monotherapy Should Not Be Recommended for Cardioprotection in Patients With Symptomatic Peripheral Artery Disease. ( 28847795 )
2017
30
Long-term cardiovascular outcome, use of resources, and healthcare costs in patients with peripheral artery disease: Results from a nationwide Swedish study. ( 28950310 )
2017
31
Noninvasive Peripheral Artery Disease Screening Tools: A Deficient Knowledge among French Vascular Residents from 4 Medical Schools. ( 28887241 )
2017
32
The Effect of Structured Patient Education on Physical Activity in Patients with Peripheral Arterial Disease and Intermittent Claudication: A Systematic Review. ( 28528678 )
2017
33
Sudomotor function in diabetic peripheral artery disease: a role for diabetic neuropathy? ( 28914379 )
2017
34
Exercise Oximetry and Exercise Near-infrared Spectroscopy to Assess Peripheral Artery Disease. ( 28076013 )
2017
35
Motivators and Barriers to Walking in Older Adults With Peripheral Artery Disease. ( 28895972 )
2017
36
Disruption of mitochondrial quality control in peripheral artery disease: New therapeutic opportunities. ( 27876411 )
2017
37
Upper Extremity Medial Arterial Calcification and Peripheral Artery Disease in Asymptomatic Patients With Chronic Kidney Disease in Predialysis Stage. ( 28823179 )
2017
38
Socioeconomic Status and Incidence of Hospitalization With Lower-Extremity Peripheral Artery Disease: Atherosclerosis Risk in Communities Study. ( 28862929 )
2017
39
Ticagrelor versus Clopidogrel in Symptomatic Peripheral Artery Disease. ( 27959717 )
2017
40
Association of arterial calcification with chronic limb ischemia in patients with peripheral artery disease. ( 28870682 )
2017
41
Re: The Survival Benefit of Kidney Transplantation in the Setting of Combined Peripheral Arterial Disease and End-Stage Renal Failure. ( 28208552 )
2017
42
Dietary intake and peripheral arterial disease incidence in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study. ( 28077376 )
2017
43
Lipoprotein-associated phospholipase A2 and risk of incident peripheral arterial disease in a multi-ethnic cohort: The Multi-Ethnic Study of Atherosclerosis. ( 28215109 )
2017
44
Ischaemic stroke and peripheral artery disease. ( 28839294 )
2017
45
IL1RL1 single nucleotide polymorphism predicts sST2 level and mortality in coronary and peripheral artery disease. ( 28110258 )
2017
46
Serum high mobility group box-1 and osteoprotegerin levels are associated with peripheral arterial disease and critical limb ischemia in type 2 diabetic subjects. ( 28789654 )
2017
47
Baseline assessment and comparison of arterial anatomy, hyperemic flow, and skeletal muscle perfusion in peripheral artery disease: The Cardiovascular Cell Therapy Research Network "Patients with Intermittent Claudication Injected with ALDH Bright Cells" (CCTRN PACE) study. ( 27979038 )
2017
48
Blood Pressure and Leg Deoxygenation are Exaggerated During Treadmill Walking in Patients with Peripheral Artery Disease. ( 28819005 )
2017
49
Endothelial Cell Inflammation and Antioxidant Capacity are Associated With 6-Minute Walk Performance in Patients With Symptomatic Peripheral Artery Disease. ( 28835113 )
2017
50
Peripheral Artery Disease: To Screen or Not Screen, That Is the Question! ( 28868916 )
2017

Variations for Peripheral Artery Disease

Expression for Peripheral Artery Disease

Search GEO for disease gene expression data for Peripheral Artery Disease.

Pathways for Peripheral Artery Disease

Pathways related to Peripheral Artery Disease according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.75 APOB CCL2 CRP CST3 IL6 NLRP1
2
Show member pathways
12.47 CCL2 NOS3 VCAM1 VEGFA
3
Show member pathways
12.17 CCL2 NOS3 VCAM1 VEGFA
4
Show member pathways
12.04 APOB CCL2 CRP IL6
5 11.89 IL6 VCAM1 VEGFA
6 11.8 CCL2 IL6 SELP
7 11.77 CCL2 NOS3 VCAM1 VEGFA
8 11.73 CCL2 IL6 VCAM1
9 11.69 IL6 NOS3 VEGFA
10 11.63 CCL2 IL6 VEGFA
11 11.51 CCL2 IL6 VCAM1 VEGFA
12
Show member pathways
11.41 IL6 VCAM1 VEGFA
13 11.23 APOB IL6 SELP
14 11.02 CCL2 IL6 NOS3 VCAM1 VEGFA
15 10.99 NOS3 VEGFA
16 10.97 ACE CST3
17 10.96 CCL2 IL6 NOS3
18 10.95 CCL2 IL6 SELP VCAM1
19 10.94 NLRP1 VCAM1
20 10.85 CCL2 VEGFA
21 10.85 CRP IL6
22 10.79 VCAM1 VEGFA
23 10.74 CCL2 VCAM1

GO Terms for Peripheral Artery Disease

Cellular components related to Peripheral Artery Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 ACE APOB CCL2 CRP CST3 IL6
2 endoplasmic reticulum lumen GO:0005788 9.56 APOB CST3 IL6 PCSK9
3 external side of plasma membrane GO:0009897 9.46 ACE P2RY12 SELP VCAM1
4 extracellular space GO:0005615 9.36 ACE APOB CCL2 CRP CST3 IL6

Biological processes related to Peripheral Artery Disease according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.86 APOB CRP IL6 VEGFA
2 post-translational protein modification GO:0043687 9.84 APOB CST3 IL6 PCSK9
3 cellular response to tumor necrosis factor GO:0071356 9.72 APOB CCL2 VCAM1
4 kidney development GO:0001822 9.65 ACE PCSK9 VEGFA
5 regulation of receptor activity GO:0010469 9.65 CCL2 IL6 PCSK9 TNFRSF11B VEGFA
6 cellular protein metabolic process GO:0044267 9.62 APOB CST3 IL6 PCSK9
7 lipoprotein metabolic process GO:0042157 9.6 APOB PCSK9
8 low-density lipoprotein particle clearance GO:0034383 9.59 APOB PCSK9
9 artery morphogenesis GO:0048844 9.58 APOB VEGFA
10 positive regulation of receptor internalization GO:0002092 9.58 PCSK9 VEGFA
11 calcium-mediated signaling using intracellular calcium source GO:0035584 9.57 SELP VCAM1
12 leukocyte tethering or rolling GO:0050901 9.52 SELP VCAM1
13 response to inorganic substance GO:0010035 9.51 CST3 TNFRSF11B
14 positive regulation of leukocyte migration GO:0002687 9.49 SELP VEGFA
15 negative regulation of bone resorption GO:0045779 9.46 IL6 TNFRSF11B
16 response to lipopolysaccharide GO:0032496 9.46 APOB SELP TNFRSF11B VCAM1
17 response to carbohydrate GO:0009743 9.43 APOB CST3
18 neutrophil mediated immunity GO:0002446 9.4 ACE IL6
19 negative regulation of lipid storage GO:0010888 9.37 CRP IL6
20 inflammatory response GO:0006954 9.1 CCL2 CRP IL6 NLRP1 SELP TNFRSF11B
21 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 8.96 ACE VEGFA

Molecular functions related to Peripheral Artery Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 CCL2 IL6 TNFRSF11B VEGFA
2 low-density lipoprotein particle binding GO:0030169 9.16 CRP PCSK9
3 low-density lipoprotein particle receptor binding GO:0050750 8.8 APOB CRP PCSK9

Sources for Peripheral Artery Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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