MCID: PRP019
MIFTS: 53

Peripheral Nervous System Disease

Categories: Neuronal diseases

Aliases & Classifications for Peripheral Nervous System Disease

MalaCards integrated aliases for Peripheral Nervous System Disease:

Name: Peripheral Nervous System Disease 12 14
Peripheral Neuropathy 12 51 29 69
Peripheral Nervous System Diseases 42
Peripheral Nerve Disorders 41
Peripheral Nerve Disease 12

Classifications:



Summaries for Peripheral Nervous System Disease

NINDS : 51 Peripheral neuropathy describes damage to the peripheral nervous system, which transmits information from the brain and spinal cord to every other part of the body. More than 100 types of peripheral neuropathy have been identified, each with its own characteristic set of symptoms, pattern of development, and prognosis. Impaired function and symptoms depend on the type of nerves -- motor, sensory, or autonomic -- that are damaged.  Some people may experience temporary numbness, tingling, and pricking sensations, sensitivity to touch, or muscle weakness. Others may suffer more extreme symptoms, including burning pain (especially at night), muscle wasting, paralysis, or organ or gland dysfunction. Peripheral neuropathy may be either inherited or acquired. Causes of acquired peripheral neuropathy include physical injury (trauma) to a nerve, tumors, toxins, autoimmune responses, nutritional deficiencies, alcoholism, medical procedures, and vascular and metabolic disorders. Acquired peripheral neuropathies are caused by systemic disease, trauma from external agents, or infections or autoimmune disorders affecting nerve tissue. Inherited forms of peripheral neuropathy are caused by inborn mistakes in the genetic code or by new genetic mutations.

MalaCards based summary : Peripheral Nervous System Disease, also known as peripheral neuropathy, is related to peripheral neuropathy, myopathy, hoarseness, and hearing loss and agenesis of the corpus callosum with peripheral neuropathy, and has symptoms including back pain, headache and neuralgia. An important gene associated with Peripheral Nervous System Disease is IARS2 (Isoleucyl-TRNA Synthetase 2, Mitochondrial), and among its related pathways/superpathways are Guidance Cues and Growth Cone Motility and Neural Crest Differentiation. The drugs Stavudine and Fexofenadine have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and spinal cord, and related phenotypes are behavior/neurological and cellular

Disease Ontology : 12 A nervous system disease that affects the peripheral nervous system.

MedlinePlus : 41 your peripheral nerves are the ones outside your brain and spinal cord. like static on a telephone line, peripheral nerve disorders distort or interrupt the messages between the brain and the rest of the body. there are more than 100 kinds of peripheral nerve disorders. they can affect one nerve or many nerves. some are the result of other diseases, like diabetic nerve problems. others, like guillain-barre syndrome, happen after a virus infection. still others are from nerve compression, like carpal tunnel syndrome or thoracic outlet syndrome. in some cases, like complex regional pain syndrome and brachial plexus injuries, the problem begins after an injury. some people are born with peripheral nerve disorders. symptoms often start gradually, and then get worse. they include numbness pain burning or tingling muscle weakness sensitivity to touch treatment aims to treat any underlying problem, reduce pain and control symptoms. nih: national institute of neurological disorders and stroke

Wikipedia : 72 The peripheral nervous system (PNS) is one of the two components of the nervous system, the other part... more...

Related Diseases for Peripheral Nervous System Disease

Diseases related to Peripheral Nervous System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
id Related Disease Score Top Affiliating Genes
1 peripheral neuropathy, myopathy, hoarseness, and hearing loss 12.3
2 agenesis of the corpus callosum with peripheral neuropathy 12.2
3 autosomal recessive optic atrophy, hearing loss, and peripheral neuropathy 12.0
4 cervical hypertrichosis peripheral neuropathy 12.0
5 sensory peripheral neuropathy 12.0
6 motor peripheral neuropathy 12.0
7 autonomic peripheral neuropathy 12.0
8 deafness peripheral neuropathy arterial disease 11.8
9 autosomal dominant optic atrophy and peripheral neuropathy 11.8
10 non-progressive predominantly posterior cavitating leukoencephalopathy with peripheral neuropathy 11.8
11 leigh-like basal ganglia disease-optic atrophy-peripheral neuropathy syndrome 11.8
12 mednik syndrome 11.6
13 hereditary proximal myopathy with early respiratory failure 11.0 MPZ PMP22
14 chromosome 16p13.2 deletion syndrome 11.0 GJB1 MPZ PMP22
15 postpartum depression 11.0 PMP22 TRPV1
16 hemiplegia alterans 11.0 MPZ PMP22
17 conotruncal heart malformations 11.0 GJB1 MPZ PMP22
18 charcot-marie-tooth neuropathy type 4j 11.0 GJB1 MPZ PMP22
19 mental retardation, x-linked, syndromic 34 11.0 GJB1 MPZ PMP22
20 charcot-marie-tooth disease, type 1b 11.0 GJB1 MPZ PMP22
21 hypertrophic osteoarthropathy, primary, autosomal recessive 2 10.9 GJB1 MPZ PMP22
22 pyosalpinx 10.9 PMP22 PSMD9 TTR
23 alopecia-mental retardation syndrome 3 10.9 PMP22 PSMD9 TTR
24 renal dysplasia, cystic 10.9 GJB1 MPZ PMP22
25 congestive heart failure 10.9 MPZ PMP22
26 hypermobility of coccyx 10.9 NGF TRPV1
27 bacterial meningitis 10.9 KANTR MT-ND4 TUBB3
28 spinal canal and spinal cord meningioma 10.9 CD40LG KANTR
29 lung lymphoma 10.9 MYOM2 TTR TUBB3
30 mohr-tranebjaerg syndrome 10.9 MAG MPZ PMP22
31 pituitary adenoma, growth hormone-secreting 10.9 MFN2 MPZ PMP22
32 secondary hypertrophic osteoarthropathy 10.9 GJB1 PMP22
33 esotropia 10.9 KANTR TTR TUBB3
34 tracheopathia osteoplastica 10.9 KANTR MPZ
35 benign paroxysmal positional nystagmus 10.9 CD40LG KANTR TUBB3
36 cardiovascular cancer 10.9 CD40LG KANTR TUBB3
37 uterine ligament papillary cystadenoma 10.9 CD40LG MAG MYOM2
38 choreatic disease 10.9 CD40LG MPZ PMP22
39 survival motor neuron spinal muscular atrophy 10.9 PSMD9 TRPV1 TTR
40 cannabis dependence 10.9 CD40LG MAG
41 female breast nipple and areola cancer 10.9 CD40LG MYOM2 PMP22
42 acute hemorrhagic encephalitis 10.9 CD40LG MAG MYOM2
43 lymphoma 10.9 CD40LG MUSK TRPV1
44 anal colloid adenocarcinoma 10.9 CD40LG KANTR MUSK
45 charcot-marie-tooth disease, recessive intermediate, a 10.8 GDAP1 MFN2 TUBB3
46 orofacial cleft 12 10.8 GDAP1 GJB1 MFN2
47 indolent myeloma 10.8 CD40LG MAG MYOM2
48 submandibular gland disease 10.8 CD40LG MAG
49 spongiotic dermatitis 10.8 MPZ MUSK PMP22
50 arteriosclerosis 10.8 CD40LG MAG MYOM2

Graphical network of the top 20 diseases related to Peripheral Nervous System Disease:



Diseases related to Peripheral Nervous System Disease

Symptoms & Phenotypes for Peripheral Nervous System Disease

UMLS symptoms related to Peripheral Nervous System Disease:


back pain, headache, neuralgia, pain, sciatica, seizures, syncope, tremor, chronic pain, atypical facial pain, neurologic symptoms, vertigo/dizziness, sleeplessness, hemiparesis

MGI Mouse Phenotypes related to Peripheral Nervous System Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.03 AQP4 GDAP1 GJB1 MAG MFN2 MPZ
2 cellular MP:0005384 9.9 CD40LG GDAP1 GJB1 MFN2 MPZ MUSK
3 homeostasis/metabolism MP:0005376 9.77 PHOX2B PNPLA6 TRPV1 TTR AQP4 CD40LG
4 nervous system MP:0003631 9.47 MPZ MUSK NGF PHOX2B PMP22 PNPLA6

Drugs & Therapeutics for Peripheral Nervous System Disease

Drugs for Peripheral Nervous System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1654)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Stavudine Approved, Investigational Phase 4,Phase 3,Phase 2 3056-17-5 18283
2
Fexofenadine Approved Phase 4,Phase 1 83799-24-0 3348
3
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 60142-96-3 3446
4
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 75614-87-8, 51-45-6 774
5
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 148553-50-8 5486971
6
Imipramine Approved Phase 4,Phase 3 50-49-7 3696
7
Etoricoxib Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 202409-33-4 123619
8
Capsaicin Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 404-86-4 1548943
9
Ketamine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 6740-88-1 3821
10
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 83-43-2 6741
11
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-24-8 5755
12
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
13
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1 103-90-2 1983
14
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 57-27-2 5288826
15
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1994-09-7, 94-09-7 2337
16
Acetylcholine Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 51-84-3 187
17
Atenolol Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 29122-68-7 2249
18
Valsartan Approved, Investigational Phase 4,Phase 1 137862-53-4 60846
19
Rocuronium Approved Phase 4,Phase 3,Phase 2,Phase 1 119302-91-9, 143558-00-3 441290
20
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-78-2 2244
21
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
22
Methylphenidate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 113-45-1 4158
23
Galantamine Approved Phase 4,Phase 3,Phase 2,Phase 1 357-70-0 9651
24
Nicotine Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 54-11-5 942 89594
25
Citalopram Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 59729-33-8 2771
26 Beractant Approved Phase 4 108778-82-1
27
Budesonide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51333-22-3 63006 5281004
28
Enalapril Approved, Vet_approved Phase 4,Phase 2 75847-73-3 5362032 40466924
29
Enalaprilat Approved Phase 4,Phase 2 76420-72-9 6917719
30
Rimonabant Approved, Investigational Phase 4 168273-06-1, 158681-13-1 104850
31
Simvastatin Approved Phase 4,Phase 3,Phase 2,Phase 1 79902-63-9 54454
32
Fluoxetine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 54910-89-3 3386
33
Fluvoxamine Approved, Investigational Phase 4,Phase 3 54739-18-3 3404 5324346
34
Paroxetine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61869-08-7 43815
35
Sertraline Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 79617-96-2 68617
36
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1 76-42-6 5284603
37
Tramadol Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 27203-92-5 33741
38
Cilostazol Approved Phase 4,Phase 3,Phase 2,Phase 1 73963-72-1 2754
39
Everolimus Approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 159351-69-6 6442177
40
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
41
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 53123-88-9 5284616 6436030 46835353
42
Ticlopidine Approved Phase 4,Phase 2,Phase 3,Phase 1 55142-85-3 5472
43
Carbidopa Approved Phase 4,Phase 3,Phase 2,Phase 1 28860-95-9 34359 38101
44
Levodopa Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 59-92-7 6047
45
Carbamazepine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 298-46-4 2554
46
Bupropion Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 34841-39-9, 34911-55-2 444
47
Mianserin Approved Phase 4,Phase 3,Phase 2,Early Phase 1 24219-97-4 4184
48
Mirtazapine Approved Phase 4,Phase 3,Phase 2,Early Phase 1 85650-52-8, 61337-67-5 4205
49
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-41-2 439260
50
Trazodone Approved, Investigational Phase 4,Phase 3,Phase 2 19794-93-5 5533

Interventional clinical trials:

(show top 50) (show all 8546)

id Name Status NCT ID Phase Drugs
1 Bi-Axial Rotating Magnetic Field Therapy in Refractory Neuropathic Foot Pain Secondary to Diabetic Peripheral Neuropathy Unknown status NCT00123136 Phase 4
2 Evaluation of Viral Efficacy and Safety of a Reduced Dose of Stavudine (d4T): THE PHOENIX STUDY Unknown status NCT00235222 Phase 4 stavudine
3 Pregabalin for the Treatment of Uremic Pruritus Unknown status NCT01852318 Phase 4 pregabalin 75mg daily for 12 weeks;fexofenadine 60 mg daily for 12 weeks;placebo
4 A Post-marketing Evaluation of a Compound Traditional Chinese Herbal Medicine, Qishe Pill, on Cervical Radiculopathy Unknown status NCT01875562 Phase 4 Qishe Pill
5 Imipramine and Pregabalin Combination in Painful Polyneuropathy Unknown status NCT01047488 Phase 4 Imipramine;Pregabalin;Imipramine, pregabalin;Placebo
6 Evaluation of the Efficacy, Tolerability and Safety of Etoricoxib (Arcoxia) in Patients With Neuropathic Pain Unknown status NCT01264237 Phase 4 Etoricoxib;Placebo
7 Qutenza for Critical Ischaemia in End Stage Renal Failure Unknown status NCT01704339 Phase 4 QUTENZA
8 Conservative Versus Aggressive Discectomy for Primary Disc Herniation With Radiculopathy Unknown status NCT01204008 Phase 4
9 Preventing Pain After Heart Surgery Unknown status NCT01480765 Phase 4 Pregabalin;Ketamine infusion;Placebo capsules;Placebo infusion
10 Inspiratory Muscle Training in Patients With Autonomic Neuropathic Unknown status NCT00752440 Phase 4
11 Effects of Pregabalin on Mechanical Hyperalgesia Unknown status NCT00310583 Phase 4 Pregabalin
12 Muscular Electrostimulation of the Sedated and Mechanically Ventilated Critically Ill Patient. Analysis of the Effect on Acquired Muscular Weakness and Its Clinical Consequences. Unknown status NCT02033057 Phase 4
13 A Phase IV Trial of Neuroprotection With ACTH in Acute Optic Neuritis Unknown status NCT01838174 Phase 4 ACTHAR Gel (ACTH);IV steroids with oral taper
14 Pregabalin for the Treatment and Prevention of Spinal Cord Injury Neuropathic Pain Unknown status NCT01479556 Phase 4 Pregabalin;Placebo
15 Evaluation of the Impact of Training on Outcome Measures in Subjects With Painful Diabetic Neuropathy Unknown status NCT01770964 Phase 4 Pregabalin;placebo
16 IV Paracetamol vs IV Morphine vs Placebo in Sciatalgia Unknown status NCT02504996 Phase 4 Paracetamol;morphine;Placebo
17 Normal Oxygenation Versus Hyperoxia in the Intensive Care Unit (ICU) Unknown status NCT01319643 Phase 4 Oxygen
18 Glucagon Like Peptides Receptors Expression in the Stomach of Diabetes Type 2 Unknown status NCT00473733 Phase 4
19 Botulinum A Toxin in Patients With Parkinson's Disease Unknown status NCT00822913 Phase 4 Intravesical injection of Botulinum A toxin
20 Comparison of Peripheral and Cerebral Arterial Flow in Acute Ischemic Stroke: Fimasartan vs. Valsartan vs. Atenolol Unknown status NCT02403349 Phase 4 Fimasartan;Valsartan;Atenolol
21 Laparoscopic Bariatric Surgery: Impact of Deep Neuromuscular Block on Surgical Conditions Unknown status NCT02118844 Phase 4 rocuronium
22 Residual Platelet Activity In Advanced Peripheral Artery Disease Unknown status NCT01627431 Phase 4 Acetylsalicylic acid;Clopidogrel
23 Identify Peripheral Biomarkers of Symptomatology, Neurocognitive Functions, and Medication Response in ADHD Unknown status NCT02074228 Phase 4 Methylphenidate (Concerta)
24 Diffusion Tensor Weighted MRI in Alzheimer's Disease Modifying Treatment Effects of Galantamine (Reminyl®) Unknown status NCT00523666 Phase 4 Galantamine (Reminyl®);Placebo/Galantamine (Reminyl®)
25 Nicotine Treatment of Impulsivity in Parkinson's Disease Unknown status NCT01216904 Phase 4 nicotine patch;placebo
26 Cardiovascular Effects of Agomelatine and Escitalopram in Patients With Major Depressive Disorder (MDD) Unknown status NCT01483053 Phase 4 Agomelatine;Escitalopram
27 Prevention of Chronic Lung Disease (CLD) in Preterm Infants Unknown status NCT00883532 Phase 4 budesonide;surfactant and air (placebo)
28 Adverse Effects of Glucocorticoid Therapy on Bone in Childhood Crohn's Disease Unknown status NCT00609752 Phase 4 prednisolone
29 Early Detection of Atherosclerosis: a Randomized Trial in the Primary Prevention of Cardiovascular Diseases. Unknown status NCT00734123 Phase 4 Simvastatin or Atorvastatin;Enalapril;Aspirin or clopidogrel;Rimonabant
30 Inhaler Lung Deposition in Chronic Obstructive Pulmonary Disease (COPD) Unknown status NCT01721291 Phase 4 SALBUTAMOL
31 The Efficacy of Methylprednisolone in the Treatment of Patients With Ocular Involvement in Behcet's Disease Unknown status NCT01306955 Phase 4 methylorednisolone
32 Magnetic Resonance Imaging Study of Cognitive-Behavior Therapy for Major Depressive Disorder Unknown status NCT01460212 Phase 4 SSRI antidepressants
33 Opioids in Chronic Kidney Disease Patients Undergoing Hemodialysis Unknown status NCT02452437 Phase 4 Oxycodone
34 Comparing Treatment Efficacy With HD/MD Flu Plus Sal in Chronic Obstructive Pulmonary Disease (COPD) Patients Unknown status NCT01131806 Phase 4 fluticasone/ salmeterol 125/25 mcg/puff;fluticasone/ salmeterol 250/25 mcg/puff
35 Tramadol Extended-Release (ER) for Posttraumatic Stress Disorder (PTSD) Unknown status NCT01517711 Phase 4 Tramadol;Placebo
36 Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis - SAfety & EffectiveneSS of Drug-ElUting Stents & Anti-platelet REgimen Unknown status NCT01267734 Phase 4 Triple anti-platelet therapy (TAT);Double-dose clopidogrel anti-platelet therapy (DDAT)
37 Remission of ICD by Switching Dopamine Agonist to Levodopa/Carbidopa Unknown status NCT01683253 Phase 4 Levodopa/Carbidopa(200mg/50mg)
38 The Combined Effects of omega3 Fatty Acids and Curcumin Supplementation on Inflammatory and Endothelial Factors in Migraine Patients Unknown status NCT02532023 Phase 4
39 Open Label Study of Lithium Plus Extended-Release Carbamazepine (ERC-CBZ) for Rapid Cycling Bipolar Disorder Unknown status NCT00325286 Phase 4 Lithium Plus Extended- Release Carbamazepine
40 Algorithm Guided Treatment Strategies for Major Depressive Disorder Unknown status NCT01764867 Phase 4 Escitalopram;Mirtazapine;Fluoxetine;Citalopram;Escitalopram;Paroxetine;Sertraline;Fluvoxamine;Venlafaxine;Duloxetine;Mirtazapine;Bupropion;Trazodone
41 Prevention of Posttraumatic Stress Disorder (PTSD) With Diazepam Unknown status NCT01221883 Phase 4 Diazepam
42 The Relationship Between Risperdal Treatment and Quality of Life in Patients With Alzheimer's Disease and Behavioural and Psychological Symptoms of Dementia (BPSD) Unknown status NCT00626613 Phase 4 Risperdal,reminyl
43 Metoprolol and Formoterol in Chronic Obstructive Pulmonary Disease (COPD) Unknown status NCT00288548 Phase 4 Metoprolol
44 Treatment Youth With Obsessive-Compulsive Disorder Unknown status NCT00708240 Phase 4 Escitalopram
45 Can Advair and Flovent Reduce Systemic Inflammation Related to Chronic Obstructive Pulmonary Disease (COPD)? A Multi-Center Randomized Controlled Trial Unknown status NCT00120978 Phase 4 Advair;Flovent
46 Efficacy and Safety of Tulobuterol Patch Combined With Tiotropium Bromide for Relieving Dyspnea Symptom of Chronic Obstructive Pulmonary Disease Unknown status NCT01465906 Phase 4 tulobuterol;Tiotropium Bromide;tiotropium bromide
47 Medications for the Treatment of Dysthymic Disorder and Double Depression Unknown status NCT00234312 Phase 4 escitalopram and sertraline
48 Efficacy and Safety of Mitoxantrone in Patients With Refractory Neuromyelitis Optica and Spectrum Disorders Unknown status NCT02021825 Phase 4 Mitoxantrone
49 Extra-fine Formoterol/Beclomethasone in Asthmatic Crisis Unknown status NCT02345993 Phase 4 Extra fine Formoterol/Beclomethasone
50 Study of Fibromyalgia Treated With Milnacipran Unknown status NCT01125423 Phase 4 Milnacipran

Search NIH Clinical Center for Peripheral Nervous System Disease

Cochrane evidence based reviews: peripheral nervous system diseases

Genetic Tests for Peripheral Nervous System Disease

Genetic tests related to Peripheral Nervous System Disease:

id Genetic test Affiliating Genes
1 Peripheral Neuropathy 29

Anatomical Context for Peripheral Nervous System Disease

MalaCards organs/tissues related to Peripheral Nervous System Disease:

39
Brain, Lung, Spinal Cord, Heart, Eye, Testes, Bone

Publications for Peripheral Nervous System Disease

Articles related to Peripheral Nervous System Disease:

id Title Authors Year
1
Biological role of dystroglycan in Schwann cell function and its implications in peripheral nervous system diseases. ( 20625412 )
2010
2
Anti-intercellular adhesion molecule-1 (ICAM-1) antibody treatment prevents central and peripheral nervous system disease in autoimmune-prone mice. ( 9364423 )
1997
3
Amyloid and peripheral nervous system disease. ( 8187375 )
1994
4
Amyloid and peripheral nervous system disease. ( 7889698 )
1994
5
The distinction between central and peripheral nervous system disease. ( 3022858 )
1986
6
Giant axonal neuropathy: combined central and peripheral nervous system disease. ( 217319 )
1979

Variations for Peripheral Nervous System Disease

ClinVar genetic disease variations for Peripheral Nervous System Disease:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 NEFL NM_006158.4(NEFL): c.64C> T (p.Pro22Ser) single nucleotide variant Pathogenic/Likely pathogenic rs28928910 GRCh37 Chromosome 8, 24813966: 24813966
2 IARS2 NM_018060.3(IARS2): c.2726C> T (p.Pro909Leu) single nucleotide variant Pathogenic rs587783070 GRCh38 Chromosome 1, 220143109: 220143109

Copy number variations for Peripheral Nervous System Disease from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 107001 17 11200000 15900000 Copy number Peripheral neuropathy

Expression for Peripheral Nervous System Disease

Search GEO for disease gene expression data for Peripheral Nervous System Disease.

Pathways for Peripheral Nervous System Disease

Pathways related to Peripheral Nervous System Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.2 GDAP1 MAG NGF
2 10.93 GJB1 MPZ PHOX2B PMP22

GO Terms for Peripheral Nervous System Disease

Cellular components related to Peripheral Nervous System Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.73 AQP4 CD40LG GDAP1 GJB1 MAG MFN2
2 compact myelin GO:0043218 8.62 MAG PMP22

Biological processes related to Peripheral Nervous System Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 mitochondrial fusion GO:0008053 8.96 GDAP1 MFN2
2 cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 8.62 MAG MPZ

Sources for Peripheral Nervous System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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