MCID: PRP019
MIFTS: 53

Peripheral Nervous System Disease

Categories: Neuronal diseases

Aliases & Classifications for Peripheral Nervous System Disease

MalaCards integrated aliases for Peripheral Nervous System Disease:

Name: Peripheral Nervous System Disease 12 14
Peripheral Neuropathy 12 72 50 28 69
Peripheral Nervous System Diseases 41
Peripheral Nerve Disorders 40
Peripheral Nerve Disease 12

Classifications:



Summaries for Peripheral Nervous System Disease

NINDS : 50 Peripheral neuropathy describes damage to the peripheral nervous system, which transmits information from the brain and spinal cord to every other part of the body. More than 100 types of peripheral neuropathy have been identified, each with its own characteristic set of symptoms, pattern of development, and prognosis. Impaired function and symptoms depend on the type of nerves -- motor, sensory, or autonomic -- that are damaged.  Some people may experience temporary numbness, tingling, and pricking sensations, sensitivity to touch, or muscle weakness. Others may suffer more extreme symptoms, including burning pain (especially at night), muscle wasting, paralysis, or organ or gland dysfunction. Peripheral neuropathy may be either inherited or acquired. Causes of acquired peripheral neuropathy include physical injury (trauma) to a nerve, tumors, toxins, autoimmune responses, nutritional deficiencies, alcoholism, medical procedures, and vascular and metabolic disorders. Acquired peripheral neuropathies are caused by systemic disease, trauma from external agents, or infections or autoimmune disorders affecting nerve tissue. Inherited forms of peripheral neuropathy are caused by inborn mistakes in the genetic code or by new genetic mutations.

MalaCards based summary : Peripheral Nervous System Disease, also known as peripheral neuropathy, is related to motor peripheral neuropathy and sensory peripheral neuropathy, and has symptoms including neurologic symptoms, hemiparesis and sleeplessness. An important gene associated with Peripheral Nervous System Disease is IARS2 (Isoleucyl-TRNA Synthetase 2, Mitochondrial), and among its related pathways/superpathways are Guidance Cues and Growth Cone Motility and Neural Crest Differentiation. The drugs Ethanol and Norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, breast and brain, and related phenotypes are behavior/neurological and cellular

MedlinePlus : 40 Your peripheral nerves are the ones outside your brain and spinal cord. Like static on a telephone line, peripheral nerve disorders distort or interrupt the messages between the brain and the rest of the body. There are more than 100 kinds of peripheral nerve disorders. They can affect one nerve or many nerves. Some are the result of other diseases, like diabetic nerve problems. Others, like Guillain-Barre syndrome, happen after a virus infection. Still others are from nerve compression, like carpal tunnel syndrome or thoracic outlet syndrome. In some cases, like complex regional pain syndrome and brachial plexus injuries, the problem begins after an injury. Some people are born with peripheral nerve disorders. Symptoms often start gradually, and then get worse. They include Numbness Pain Burning or tingling Muscle weakness Sensitivity to touch Treatment aims to treat any underlying problem, reduce pain and control symptoms. NIH: National Institute of Neurological Disorders and Stroke

Disease Ontology : 12 A nervous system disease that affects the peripheral nervous system.

Wikipedia : 72 Peripheral neuropathy (PN) is damage to or disease affecting nerves, which may impair sensation,... more...

Related Diseases for Peripheral Nervous System Disease

Diseases related to Peripheral Nervous System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)
# Related Disease Score Top Affiliating Genes
1 motor peripheral neuropathy 34.0 GJB1 MFN2 MPZ PMP22
2 sensory peripheral neuropathy 33.8 GDAP1 GJB1 MAG MFN2 MPZ NGF
3 foot drop 32.1 MPZ PMP22
4 diabetic neuropathy 31.9 MPZ NGF PMP22 TRPV1
5 axonal neuropathy 30.3 GDAP1 MFN2 PMP22
6 nervous system disease 30.2 AQP4 CD40LG KANTR MAG MT-ND4 NGF
7 neuropathy 29.6 GDAP1 GJB1 IARS2 MFN2 MPZ MT-ND4
8 peripheral neuropathy, myopathy, hoarseness, and hearing loss 12.4
9 agenesis of the corpus callosum with peripheral neuropathy 12.3
10 mental retardation, enteropathy, deafness, peripheral neuropathy, ichthyosis, and keratoderma 12.3
11 optic atrophy, hearing loss, and peripheral neuropathy, autosomal recessive 12.2
12 cervical hypertrichosis peripheral neuropathy 12.1
13 autonomic peripheral neuropathy 12.1
14 deafness, sensorineural, with peripheral neuropathy and arterial disease 11.9
15 optic atrophy, hearing loss, and peripheral neuropathy, autosomal dominant 11.9
16 spinocerebellar ataxia with rigidity and peripheral neuropathy 11.9
17 peripheral neuropathy, ataxia, focal necrotizing encephalopathy, and spongy degeneration of brain 11.9
18 deafness peripheral neuropathy arterial disease 11.9
19 autosomal dominant optic atrophy and peripheral neuropathy 11.9
20 non-progressive predominantly posterior cavitating leukoencephalopathy with peripheral neuropathy 11.9
21 optic atrophy-peripheral neuropathy-developmental delay syndrome 11.9
22 cauda equina syndrome 10.9
23 hereditary neuropathy with liability to pressure palsy 10.7 MPZ PMP22
24 mononeuritis of lower limb 10.7 PMP22 TRPV1
25 charcot-marie-tooth neuropathy type 1 10.7 GJB1 MPZ PMP22
26 charcot-marie-tooth disease, demyelinating, type 1f 10.7 GJB1 MPZ PMP22
27 charcot-marie-tooth disease, demyelinating, type 1b 10.6 GJB1 MPZ PMP22
28 charcot-marie-tooth disease, axonal, type 2b 10.6 GJB1 MPZ PMP22
29 nerve compression syndrome 10.6 PMP22 PSMD9 TTR
30 charcot-marie-tooth disease, x-linked dominant, 1 10.6 GDAP1 GJB1 MPZ
31 charcot-marie-tooth disease, demyelinating, type 1d 10.6 GJB1 MPZ PMP22
32 lesion of sciatic nerve 10.6 NGF TRPV1
33 charcot-marie-tooth disease, demyelinating, type 1c 10.6 GJB1 MPZ PMP22
34 congenital hypomyelination neuropathy 10.6 MPZ PMP22
35 amyloid tumor 10.6 MYOM2 TTR TUBB3
36 carpal tunnel syndrome 10.6 PMP22 PSMD9 TTR
37 adie pupil 10.6 KANTR MPZ
38 pelizaeus-merzbacher disease 10.6 MAG MPZ PMP22
39 exposure keratitis 10.6 KANTR MT-ND4 TUBB3
40 amyotrophic neuralgia 10.6 GJB1 PMP22
41 mononeuritis multiplex 10.6 CD40LG MAG
42 facial paralysis 10.6 CD40LG KANTR TUBB3
43 acquired metabolic disease 10.6 PSMD9 TRPV1 TTR
44 hypertropia 10.6 KANTR TTR TUBB3
45 guillain-barre syndrome 10.6 CD40LG MPZ PMP22
46 mononeuritis of upper limb and mononeuritis multiplex 10.6 CD40LG MAG MYOM2
47 hypersensitivity reaction disease 10.6 CD40LG MUSK TRPV1
48 facial nerve disease 10.6 CD40LG KANTR TUBB3
49 chronic polyneuropathy 10.6 CD40LG MAG MYOM2
50 brachial plexus neuritis 10.6 CD40LG KANTR MUSK

Graphical network of the top 20 diseases related to Peripheral Nervous System Disease:



Diseases related to Peripheral Nervous System Disease

Symptoms & Phenotypes for Peripheral Nervous System Disease

UMLS symptoms related to Peripheral Nervous System Disease:


neurologic symptoms, hemiparesis, sleeplessness, vertigo/dizziness, atypical facial pain, chronic pain, tremor, syncope, seizures, sciatica, pain, neuralgia, headache, back pain

MGI Mouse Phenotypes related to Peripheral Nervous System Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.03 AQP4 GDAP1 GJB1 MAG MFN2 MPZ
2 cellular MP:0005384 9.9 MPZ MUSK PHOX2B PMP22 PNPLA6 TRPV1
3 homeostasis/metabolism MP:0005376 9.77 AQP4 CD40LG GDAP1 GJB1 MAG MFN2
4 nervous system MP:0003631 9.47 AQP4 CD40LG GDAP1 GJB1 MAG MFN2

Drugs & Therapeutics for Peripheral Nervous System Disease

Drugs for Peripheral Nervous System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 779)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4,Phase 3,Phase 1,Phase 2 64-17-5 702
2
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-41-2 439260
3
Dopamine Approved Phase 4,Phase 3,Phase 2 51-61-6, 62-31-7 681
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-02-2 5743
5
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 60142-96-3 3446
6
Carbamazepine Approved, Investigational Phase 4,Phase 2,Phase 3 298-46-4 2554
7
Imipramine Approved Phase 4 50-49-7 3696
8
Paclitaxel Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 33069-62-4 36314
9
Fexofenadine Approved, Investigational Phase 4 83799-24-0 3348
10
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
11
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 57-27-2 5288826
12
Acetaminophen Approved Phase 4,Phase 3,Phase 2 103-90-2 1983
13
Acetylcholine Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 51-84-3 187
14
Histamine Approved, Investigational Phase 4,Phase 2 51-45-6, 75614-87-8 774
15
Naloxone Approved, Vet_approved Phase 4,Phase 2 465-65-6 5284596
16
Stavudine Approved, Investigational Phase 4,Phase 3 3056-17-5 18283
17
Capsaicin Approved Phase 4,Phase 2,Phase 3,Phase 1 404-86-4 1548943
18
Dronabinol Approved, Illicit Phase 4,Phase 3,Phase 2 1972-08-3 16078 2978
19
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-24-8 5755
20
Naproxen Approved, Vet_approved Phase 4,Phase 2 22204-53-1 156391 1302
21
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 137-58-6 3676
22
Remifentanil Approved Phase 4,Phase 3 132875-61-7 60815
23
Amitriptyline Approved Phase 4,Phase 3,Phase 2 50-48-6 2160
24
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 38396-39-3, 2180-92-9 2474
25
Ketamine Approved, Vet_approved Phase 4,Phase 3,Phase 2 6740-88-1 3821
26
Minocycline Approved, Investigational Phase 4,Phase 2 10118-90-8 5281021
27
Nabilone Approved, Investigational Phase 4,Phase 3,Phase 2 51022-71-0 5284592
28
Etoricoxib Approved, Investigational Phase 4,Phase 2 202409-33-4 123619
29
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 124-94-7 31307
30
Perphenazine Approved Phase 4,Phase 3,Phase 2 58-39-9 4748
31
Tramadol Approved, Investigational Phase 4,Phase 3,Phase 2 27203-92-5 33741
32
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2 76-42-6 5284603
33
Oxcarbazepine Approved Phase 4 28721-07-5 34312
34
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
35
Ropivacaine Approved Phase 4,Phase 3,Phase 2 84057-95-4 175805 71273
36
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1 148553-50-8 5486971
37
Hydroxocobalamin Approved Phase 4,Phase 3,Phase 2 13422-51-0 5460373 44475014 11953898
38
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 83-43-2 6741
39
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
40
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 93-14-1 3516
41
Levobupivacaine Approved, Investigational Phase 4,Phase 3 27262-47-1 92253
42
gamma-Aminobutyric acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 56-12-2 119
43 Racepinephrine Approved Phase 4 329-65-7
44
Methotrexate Approved Phase 4,Phase 2,Phase 3 1959-05-2, 59-05-2 126941
45
Carboplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 41575-94-4 10339178 38904 498142
46
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2 59467-70-8 4192
47
Ibuprofen Approved Phase 4,Phase 2,Phase 3 15687-27-1 3672
48
Quinapril Approved, Investigational Phase 4 85441-61-8 54892
49
Metoprolol Approved, Investigational Phase 4 51384-51-1, 37350-58-6 4171
50
Donepezil Approved Phase 4,Phase 2,Phase 1 120014-06-4 3152

Interventional clinical trials:

(show top 50) (show all 2268)

# Name Status NCT ID Phase Drugs
1 Bi-Axial Rotating Magnetic Field Therapy in Refractory Neuropathic Foot Pain Secondary to Diabetic Peripheral Neuropathy Unknown status NCT00123136 Phase 4
2 Evaluation of Viral Efficacy and Safety of a Reduced Dose of Stavudine (d4T): THE PHOENIX STUDY Unknown status NCT00235222 Phase 4 stavudine
3 Pregabalin for the Treatment of Uremic Pruritus Unknown status NCT01852318 Phase 4 pregabalin 75mg daily for 12 weeks;fexofenadine 60 mg daily for 12 weeks;placebo
4 A Post-marketing Evaluation of a Compound Traditional Chinese Herbal Medicine, Qishe Pill, on Cervical Radiculopathy Unknown status NCT01875562 Phase 4 Qishe Pill
5 Imipramine and Pregabalin Combination in Painful Polyneuropathy Unknown status NCT01047488 Phase 4 Imipramine;Pregabalin;Imipramine, pregabalin;Placebo
6 Evaluation of the Efficacy, Tolerability and Safety of Etoricoxib (Arcoxia) in Patients With Neuropathic Pain Unknown status NCT01264237 Phase 4 Etoricoxib;Placebo
7 Conservative Versus Aggressive Discectomy for Primary Disc Herniation With Radiculopathy Unknown status NCT01204008 Phase 4
8 Muscular Electrostimulation of the Sedated and Mechanically Ventilated Critically Ill Patient. Analysis of the Effect on Acquired Muscular Weakness and Its Clinical Consequences. Unknown status NCT02033057 Phase 4
9 Preventing Pain After Heart Surgery Unknown status NCT01480765 Phase 4 Pregabalin;Ketamine infusion;Placebo capsules;Placebo infusion
10 IV Paracetamol vs IV Morphine vs Placebo in Sciatalgia Unknown status NCT02504996 Phase 4 Paracetamol;morphine;Placebo
11 Qutenza for Critical Ischaemia in End Stage Renal Failure Unknown status NCT01704339 Phase 4 QUTENZA
12 A Phase IV Trial of Neuroprotection With ACTH in Acute Optic Neuritis Unknown status NCT01838174 Phase 4 ACTHAR Gel (ACTH);IV steroids with oral taper
13 Evaluation of the Impact of Training on Outcome Measures in Subjects With Painful Diabetic Neuropathy Unknown status NCT01770964 Phase 4 Pregabalin;placebo
14 Pregabalin for the Treatment and Prevention of Spinal Cord Injury Neuropathic Pain Unknown status NCT01479556 Phase 4 Pregabalin;Placebo
15 Effects of Pregabalin on Mechanical Hyperalgesia Unknown status NCT00310583 Phase 4 Pregabalin
16 Inspiratory Muscle Training in Patients With Autonomic Neuropathic Unknown status NCT00752440 Phase 4
17 Safety and Efficacy of Mecobalamin Injection in Peripheral Neuropathies Patients (Study JGAZSY091109) Completed NCT01192113 Phase 4 Mecobalamin IV Injection;Mecobalamin IM injection;Mecobalamin IV or IM injection
18 A Study to Assess the Efficacy and Safety of Oxycodone/Naloxone in Korean Patients With Chemotherapy-Induced Peripheral Neuropathy (CIPN) Completed NCT01675531 Phase 4 Targin
19 Safety of Pregabalin in the Treatment of Pain Due to Diabetic Peripheral Neuropathy Completed NCT00159731 Phase 4 Pregabalin
20 Study of Metanx® in Subjects With Type 2 Diabetic Peripheral Neuropathy (DPN) Completed NCT00726713 Phase 4
21 Autonomic Nervous System Dysfunction and Peripheral Neuropathy in a Cohort of Asymptomatic Juvenile Diabetic Patients (Type I): A Case-Controlled Study Completed NCT00466778 Phase 4
22 Efficacy of Administration of ACE-Inhibition on Autonomic and Peripheral Neuropathy in Patients With Diabetes Mellitus Completed NCT03031834 Phase 4 Quinapril
23 Evaluation of the Efficacy of Cesamet™ for the Treatment of Pain in Patients With Diabetic Peripheral Neuropathy Completed NCT00380913 Phase 4 Cesamet™ (nabilone)
24 Pregabalin in the Treatment of Pain Due to Diabetic Peripheral Neuropathy Completed NCT00159679 Phase 4 Pregabalin
25 A Study To Evaluate Pregabalin In Patients With Painful Diabetic Peripheral Neuropathy (DPN) Completed NCT00156078 Phase 4 pregabalin
26 A Study of the Efficacy and Safety of Pregabalin for the Treatment of Diabetic Peripheral Neuropathy or Postherpetic Neuralgia Completed NCT00629681 Phase 4 Pregabalin
27 Efficacy and Safety of Gabapentin/B-complex Versus Pregabalin in Diabetic Peripheral Neuropathy Pain Management Completed NCT01364298 Phase 4 Gabapentin/B-complex;Pregabalin
28 Intrathecal Bolus Doses of Ziconotide Completed NCT01373983 Phase 4 Ziconotide
29 Pregabalin Treatment Of Peripheral Neuropathic Pain Associated With Diabetic Peripheral NeP (DPN), Postherpetic Neuralgia (PHN), HIV-related NeP (HIV), and Chemotherapy Induced NeP Completed NCT00407511 Phase 4 Pregabalin
30 Comparison of the Analgesic Effect of Different Local Anesthetics in Interscalene Nerve Block for Shoulder Surgery Completed NCT02691442 Phase 4 Ropivacaine 0.75%;Levobupivacaine 0.5%;Levobupivacaine 0.5% + epinephrin 1/200000
31 Effect of Pulsing Electrical Fields on Lower Extremity Diabetic Neuropathy: A Pilot, Open-Label Study Completed NCT00614341 Phase 4
32 Evaluation of the Efficacy of Cesamet™ for the Treatment of Pain in Patients With Chemotherapy-Induced Neuropathy Completed NCT00380965 Phase 4 Cesamet™ (nabilone)
33 Frequency Modulated Neural Stimulation (FREMS) in Symptomatic Diabetic Neuropathy Completed NCT01628627 Phase 4
34 A Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
35 Safety and Efficacy Study of Abraxane in Combination With Carboplatin to Treat Advanced NSCL Cancer in the Elderly Completed NCT02151149 Phase 4 nab-paclitaxel;Carboplatin
36 A Randomized Double-Blind Study Testing the Effects of Pregabalin on Diabetic Neuropathy Completed NCT00573261 Phase 4 Pregabalin;Placebo
37 Asian Study on Cilostazol Effectivity in Neuropathies of Diabetes Mellitus Type 2-A Pilot Study in the Philippines Completed NCT01076478 Phase 4 Cilostazol
38 Comparison of the Efficacy of Duloxetine With Placebo in Patients With Chronic Low Back Pain With a Radicular Component Completed NCT01166048 Phase 4 Duloxetine;Duloxetine
39 An Open Label, Dose Finding Trial of Viagra for the Treatment of Neuropathic Pain (in Diabetes Mellitus) Completed NCT00194909 Phase 4 sildenafil (Viagra)
40 Effect of Arginine on Microcirculation in Patients With Diabetes Completed NCT00902616 Phase 4
41 The Effect of α-lipoic Acid Treatment in Patient With Cardiac Autonomic Neuropathy Completed NCT02056366 Phase 4 α-lipoic acid
42 A Study to Compare Safety and Efficacy of Tramadol Hydrochloride/Acetaminophen With Gabapentin in Participants With Diabetic Neuropathy Completed NCT00634543 Phase 4 Tramadol hydrochloride/ Acetaminophen;Gabapentin
43 Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations Completed NCT02260388 Phase 4 Nortriptyline;Duloxetine;Pregabalin;Mexiletine
44 Escitalopram as a Treatment for Pain in Polyneuropathy Completed NCT00162968 Phase 4 escitalopram
45 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT03046693 Phase 4 Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
46 Arthroplasty Versus Fusion in Anterior Cervical Surgery: Prospective Study of the Impact on the Adjacent Level Completed NCT00554528 Phase 4
47 Prophylactic Administration of Vitamin C in Wrist Fractures Completed NCT00296868 Phase 4 ascorbic acid (vitamin C) versus placebo
48 Postoperative Alpha Lipoic Acid in the Carpal Tunnel Syndrome: a Randomized Controlled Trial. Completed NCT01895621 Phase 4
49 Levetiracetam for Painful Polyneuropathy Completed NCT00286260 Phase 4 levetiracetam
50 Evaluation of Rocker sOles in Diabetis Completed NCT02891928 Phase 4

Search NIH Clinical Center for Peripheral Nervous System Disease

Cochrane evidence based reviews: peripheral nervous system diseases

Genetic Tests for Peripheral Nervous System Disease

Genetic tests related to Peripheral Nervous System Disease:

# Genetic test Affiliating Genes
1 Peripheral Neuropathy 28

Anatomical Context for Peripheral Nervous System Disease

MalaCards organs/tissues related to Peripheral Nervous System Disease:

38
Spinal Cord, Breast, Brain, Testes, Cortex, Skin, Bone

Publications for Peripheral Nervous System Disease

Articles related to Peripheral Nervous System Disease:

# Title Authors Year
1
AAVrh10 gene therapy ameliorates central and peripheral nervous system disease in canine globoid cell leukodystrophy (Krabbe disease). ( 29316812 )
2018
2
Biological role of dystroglycan in Schwann cell function and its implications in peripheral nervous system diseases. ( 20625412 )
2010
3
Anti-intercellular adhesion molecule-1 (ICAM-1) antibody treatment prevents central and peripheral nervous system disease in autoimmune-prone mice. ( 9364423 )
1997
4
Amyloid and peripheral nervous system disease. ( 8187375 )
1994
5
Amyloid and peripheral nervous system disease. ( 7889698 )
1994
6
The distinction between central and peripheral nervous system disease. ( 3022858 )
1986
7
Giant axonal neuropathy: combined central and peripheral nervous system disease. ( 217319 )
1979

Variations for Peripheral Nervous System Disease

ClinVar genetic disease variations for Peripheral Nervous System Disease:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 NEFL NM_006158.4(NEFL): c.64C> T (p.Pro22Ser) single nucleotide variant Pathogenic/Likely pathogenic rs28928910 GRCh37 Chromosome 8, 24813966: 24813966
2 IARS2 NM_018060.3(IARS2): c.2726C> T (p.Pro909Leu) single nucleotide variant Pathogenic rs587783070 GRCh38 Chromosome 1, 220143109: 220143109

Copy number variations for Peripheral Nervous System Disease from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 107001 17 11200000 15900000 Copy number Peripheral neuropathy

Expression for Peripheral Nervous System Disease

Search GEO for disease gene expression data for Peripheral Nervous System Disease.

Pathways for Peripheral Nervous System Disease

Pathways related to Peripheral Nervous System Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.2 GDAP1 MAG NGF
2 10.93 GJB1 MPZ PHOX2B PMP22

GO Terms for Peripheral Nervous System Disease

Cellular components related to Peripheral Nervous System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.77 AQP4 CD40LG GDAP1 GJB1 KANTR MAG
2 compact myelin GO:0043218 8.62 MAG PMP22

Biological processes related to Peripheral Nervous System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial fusion GO:0008053 8.96 GDAP1 MFN2
2 cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 8.62 MAG MPZ

Sources for Peripheral Nervous System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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