MCID: PRP023
MIFTS: 46

Peripheral Neuropathy malady

Summaries for Peripheral Neuropathy

Sources:
8Disease Ontology, 44NINDS, 64Wikipedia, 33MalaCards
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NINDS:44 Peripheral neuropathy describes damage to the peripheral nervous system, which transmits information from the brain and spinal cord to every other part of the body.

MalaCards: Peripheral Neuropathy is related to sensory peripheral neuropathy and n syndrome. An important gene associated with Peripheral Neuropathy is SLC12A6 (solute carrier family 12 (potassium/chloride transporter), member 6), and among its related pathways are Gap junction trafficking and Membrane Trafficking. The compounds gap 27 and carbenoxolone have been mentioned in the context of this disorder. Affiliated tissues include nerves of the peripheral nervous system, and related mouse phenotypes are vision/eye and no phenotypic analysis.

Disease Ontology:8 A neuropathy that is located in nerves of the peripheral nervous system.

Wikipedia:64 Peripheral neuropathy (PN) is damage or disease affecting nerves, which may affect sensation, movement,... more...

Aliases & Classifications for Peripheral Neuropathy

Sources:
8Disease Ontology, 44NINDS, 10DISEASES, 61UMLS
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Aliases & Descriptions:

peripheral neuropathy 8 44 10 61


External Ids:

Disease Ontology8 DOID:0060053

Related Diseases for Peripheral Neuropathy

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Peripheral Neuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 366)
idRelated DiseaseScoreTop Affiliating Genes
1sensory peripheral neuropathy30.9GJB1, SLC12A6
2n syndrome10.8
3autonomic peripheral neuropathy10.5
4ataxia10.5
5motor peripheral neuropathy10.5
6autonomic neuropathy10.5
7cryoglobulinemia10.4
8postherpetic neuralgia10.4
9tooth disease10.4
10inherited peripheral neuropathy10.4
11axonal neuropathy10.4
12churg-strauss syndrome10.4
13hepatitis c10.3
14amyloid neuropathy10.3
15cervical hypertrichosis peripheral neuropathy10.3
16olivopontocerebellar atrophy10.3
17systemic lupus erythematosus10.3
18metachromatic leukodystrophy10.3
19osteosclerotic myeloma10.3
20diabetic autonomic neuropathy10.3
21acute porphyria10.3
22amyloidosis10.3
23colorectal cancer10.3
24autosomal dominant optic atrophy, hearing loss, and peripheral neuropathy10.3
25autosomal recessive optic atrophy, hearing loss, and peripheral neuropathy10.3
26spastic paraparesis10.3
27chediak-higashi syndrome10.2
28transthyretin amyloidosis10.2
29krabbe disease10.2
30hereditary spastic paraplegia10.2
31cerebrotendinous xanthomatosis10.2
32poems syndrome10.2
33hereditary motor and sensory neuropathy with agenesis of the corpus callosum10.2
34x-linked charcot-marie-tooth disease type 510.2
35deafness peripheral neuropathy arterial disease10.2
36microscopic polyangiitis10.2
37chronic pain10.2
38hepatitis c virus10.2
39peripheral vascular disease10.2
40acrodermatitis10.2
41myelitis10.2
42sciatic neuropathy10.2
43ischemic neuropathy10.2
44refsum disease10.2
45acute leukemia10.2
46hepatitis a10.2
47arthritis10.2
48spinocerebellar ataxia10.2
49tibial neuropathy10.2
50vascular disease10.2

Graphical network of the top 20 diseases related to Peripheral Neuropathy:



Diseases related to peripheral neuropathy

Clinical Features for Peripheral Neuropathy

Drugs & Therapeutics for Peripheral Neuropathy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Peripheral Neuropathy

Drug clinical trials:

Search ClinicalTrials for Peripheral Neuropathy

Search NIH Clinical Center for Peripheral Neuropathy

Search CenterWatch for Peripheral Neuropathy

Genetic Tests for Peripheral Neuropathy

Anatomical Context for Peripheral Neuropathy

Sources:
14FMA
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FMA organs/tissues related to Peripheral Neuropathy:

14
Nerves of the peripheral nervous system

Animal Models for Peripheral Neuropathy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Peripheral Neuropathy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539111.0GJC3, SLC12A6, GJB1, GJE1, GJA10, GJA8
2MP:000301210.9GJD3, GJB6, GJB3, GJA10, GJA5, GJD2
3MP:000363110.8SLC12A6, GJC2, GJB1, GJA10, GJD3, GJD2

Publications for Peripheral Neuropathy

Sources:
51PubMed
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Articles related to Peripheral Neuropathy:

(show top 50)    (show all 955)
idTitleAuthorsYear
1
Median nerve ultrasound in diabetic peripheral neuropathy with and without carpal tunnel syndrome. (23401087)
2013
2
Mosaic microdeletion of 17p11.2-p12 and duplication of 17q22-q24 in a girl with Smith-Magenis phenotype and peripheral neuropathy. (24357149)
2013
3
Peripheral neuropathy caused by cryoglobulinaemia with false-positive serological tests of syphilis. (23673128)
2013
4
Peripheral neuropathy in late-onset Krabbe disease: report of three cases. (22274816)
2013
5
Association of comorbidities with increasing severity of peripheral neuropathy in diabetes mellitus. (23961324)
2013
6
The impact of peripheral neuropathy and cognitive decrements on gait in older adults with type 2 diabetes mellitus. (23385112)
2013
7
An unusual case of subclinical peripheral neuropathy and cervical spondylosis in atopic myelitis. (24251051)
2013
8
Peripheral neuropathy--lead astray? (23540854)
2013
9
Therapeutic effects of 15 Hz pulsed electromagnetic field on diabetic peripheral neuropathy in streptozotocin-treated rats. (23637830)
2013
10
The evaluation of peripheral neuropathy in youth with type 1 diabetes. (23391743)
2013
11
Endoplasmic reticulum stress plays a key role in the pathogenesis of diabetic peripheral neuropathy. (23364451)
2013
12
Comparison of Balance Ability Between Patients With Type 2 Diabetes and With and Without Peripheral Neuropathy. (24262275)
2013
13
Prevention of paclitaxel-induced peripheral neuropathy by lithium pretreatment. (22889832)
2012
14
Ginkgo biloba extract attenuates hyperalgesia in a rat model of vincristine-induced peripheral neuropathy. (23011564)
2012
15
Retinal nerve fibre layer thinning associated with diabetic peripheral neuropathy. (22269030)
2012
16
A new phenotype of brain iron accumulation with dystonia, optic atrophy, and peripheral neuropathy. (22508347)
2012
17
Peripheral neuropathy in hereditary spastic paraplegia due to spastin (SPG4) mutation--a neurophysiological study using excitability techniques. (22192498)
2012
18
Peripheral neuropathy: evidence-based treatment of a complex disorder. (22460540)
2012
19
Goshajinkigan reduces oxaliplatin-induced peripheral neuropathy without affecting anti-tumour efficacy in rodents. (21907570)
2012
20
General aspects and mechanisms of peripheral neuropathy associated with bortezomib in patients with newly diagnosed multiple myeloma. (22726548)
2012
21
Antiallodynic effect of herbal medicine yokukansan on peripheral neuropathy in rats with chronic constriction injury. (22454692)
2012
22
Botulinum toxin effects on gasatrocnemius strength and plantar pressure in diabetics with peripheral neuropathy and forefoot ulceration. (22735277)
2012
23
Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia. (22460833)
2012
24
Comparative study of peripheral neuropathy and nerve regeneration in NOD and ICR diabetic mice. (22003936)
2011
25
Ultrasound evaluation of peripheral neuropathy in POEMS syndrome. (22102455)
2011
26
Correction and transformation of normative neurophysiological data: is there added value in the diagnosis of distal symmetrical peripheral neuropathy? (22102459)
2011
27
Insidious peripheral neuropathy occurring under treatment in infantile MTHFR deficiency. (19697151)
2009
28
The slipping slipper sign: a marker of severe peripheral diabetic neuropathy and foot sepsis. (19528301)
2009
29
Peripheral neuropathy in chromosome16q22.1 linked autosomal dominant cerebellar ataxia. (21686672)
2009
30
Cost-effectiveness of pregabalin for the management of neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia: a Canadian perspective. (17213013)
2006
31
Autoantibodies to autonomic nerves associated with cardiac and peripheral autonomic neuropathy. (16043739)
2005
32
A randomized, double-blinded, placebo-controlled phase II trial of recombinant human leukemia inhibitory factor (rhuLIF, emfilermin, AM424) to prevent chemotherapy-induced peripheral neuropathy. (15756015)
2005
33
Autosomal recessive spinocerebellar ataxia and peripheral neuropathy with raised alpha-fetoprotein. (15258781)
2004
34
Sonographic detection of diffuse peripheral nerve enlargement in hereditary neuropathy with liability to pressure palsies. (12210462)
2002
35
Peripheral neuropathy in acrodermatitis chronica atrophicans - effect of treatment. (12371917)
2002
36
Peripheral neuropathy and antiretroviral drugs. (11293802)
2001
37
Screening for mutations in the peripheral myelin genes PMP22, MPZ and Cx32 (GJB1) in Russian Charcot-Marie-Tooth neuropathy patients. (10737979)
2000
38
Peripheral neuropathy without cryoglobulinemia in patients with hepatitis C virus infection. (11218620)
2000
39
Severe peripheral neuropathy, cardiac hypofunction, and syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in a patient with Churg-Strauss syndrome]. (10614173)
1999
40
Olivopontocerebellar atrophy and peripheral neuropathy--Wadia type. (10999111)
1999
41
Screening for distal sensory peripheral neuropathy in HIV-infected persons in research and clinical settings. (9855522)
1998
42
Autonomic neuropathy in transgenic mice caused by immunotoxin targeting of the peripheral nervous system. (9469570)
1998
43
Idiopathic hypereosinophilic syndrome with eosinophilic myositis, peripheral neuropathy and central nervous system involvement. (9000811)
1996
44
Diagnosis, classification, and treatment of diabetic peripheral neuropathy. (7720030)
1995
45
Natural killer cell leukemia presenting with a peripheral neuropathy. (8414048)
1993
46
Gene dosage as a mechanism for a common autosomal dominant peripheral neuropathy: Charcot-Marie-Tooth disease type 1A. (8115402)
1993
47
Peripheral neuropathy with giant axons and cardiomyopathy associated with desmin type intermediate filaments in skeletal muscle. (1517757)
1992
48
Chronic hexosaminidase A deficiency associated with pure sensory peripheral neuropathy]. (1302293)
1992
49
Demyelinating peripheral neuropathy in Devic disease. (1667535)
1991
50
Familial congenital anterior cervical hypertrichosis associated with peripheral sensory and motor neuropathy--a new syndrome? (1666396)
1991

Genetic Variations for Peripheral Neuropathy

Expression for genes affiliated with Peripheral Neuropathy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Peripheral Neuropathy

Search GEO for disease gene expression data for Peripheral Neuropathy.

Pathways for genes affiliated with Peripheral Neuropathy

Sources:
54Reactome, 38NCBI BioSystems Database, 52QIAGEN, 30KEGG, 12EMD Millipore
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Compounds for genes affiliated with Peripheral Neuropathy

Sources:
60Tocris Bioscience, 29IUPHAR, 45Novoseek, 11DrugBank, 24HMDB, 2BitterDB
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Compounds related to Peripheral Neuropathy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1gap 276011.8GJB1, GJD4, GJE1, GJB4, GJA10, GJA8
2carbenoxolone29 45 1113.8GJE1, GJB4, GJA10, GJA8, GJD3, GJA4
3octanol29 2412.7GJB1, GJD4, GJE1, GJB4, GJA10, GJA8
4ca2+2911.7GJE1, GJB4, GJA10, GJA8, GJD3, GJA4
5flufenamic acid45 29 2 1114.6GJB1, GJD4, GJE1, GJB4, GJA10, GJA8
6carbenoxolone disodium6011.6GJE1, GJB4, GJA10, GJA8, GJD3, GJA4
710panx6011.5GJE1, GJB4, GJA10, GJA8, GJD3, GJA4
8scrambled 10panx6011.3GJB1, GJD4, GJE1, GJB4, GJA10, GJA8

GO Terms for genes affiliated with Peripheral Neuropathy

Sources:
16Gene Ontology
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Cellular components related to Peripheral Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1connexon complexGO:00592211.6GJC3, GJB6, GJB3, GJB5, GJB7, GJD2
2integral to membraneGO:01602111.1GJB6, GJA3, GJC2, GJC3, GJA9, GJD4
3gap junctionGO:00592110.7GJB4, GJB3, GJD2, GJA5, GJA4
4myelin sheathGO:04320910.6GJC2, GJC3

Biological processes related to Peripheral Neuropathy according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cell communicationGO:00715411.2GJD4, GJB5, GJB7, GJD2, GJD3, GJB4
2cell-cell signalingGO:00726710.9GJA3, GJC2, GJB1, GJA8, GJA4
3gap junction assemblyGO:01626410.8GJA5, GJB1, GJD3
4transportGO:00681010.7GJB1, GJA3, GJA8, GJA4
5visual perceptionGO:00760110.7GJA3, GJD2, GJA8
6sensory perception of soundGO:00760510.6GJC3, GJB3, GJB6
7lens development in camera-type eyeGO:00208810.3GJA8, GJE1

Molecular functions related to Peripheral Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1gap junction channel activityGO:00524310.9GJB1, GJB4, GJA10, GJD2, GJB3, GJA3

Products for genes affiliated with Peripheral Neuropathy

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Sources for Peripheral Neuropathy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet