Peripheral Neuropathy malady

NINDS: Peripheral neuropathy describes damage to the peripheral nervous system, which transmits information from the brain and spinal cord to every other part of the body.³¹

MalaCards: Peripheral Neuropathy is related to inherited peripheral neuropathy and sensory peripheral neuropathy. An important gene associated with Peripheral Neuropathy is SLC12A6 (solute carrier family 12 (potassium/chloride transporters), member 6), and among its related pathways are Signaling in Gap Junctions and Cell adhesion Gap junctions. The compounds atp and gap 26 have been mentioned in the context of this disorder. Affiliated tissues include nerves of the peripheral nervous system, bone marrow and brain, and related mouse phenotypes are liver/biliary system and cellular.

Disease Ontology: A neuropathy that is located in nerves of the peripheral nervous system.⁶

Wikipedia: Peripheral neuropathy is damage to nerves of the peripheral nervous system, which may be caused either...⁴⁴ more...

peripheral neuropathy 6 31 8 43

Diseases related to peripheral neuropathy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 911)

id	Related Disease	Score	Top Affiliating Genes
1	inherited peripheral neuropathy	34.8	CNTNAP1, CMT1A, MPZ, HSPB8, GJB1, EGR2
2	sensory peripheral neuropathy	33.3	FLVCR1, CCT4, CCT5, TNRC6A, CRIPT, PLEKHG4
3	tooth disease	32.0	MPZ, GJB1, EGR2, PMP22
4	charcot-marie-tooth disease	31.8	CMT1A, MPZ, PMP22
5	hereditary neuropathy with liability to pressure palsy	31.2	MPZ, GJB1, SH3TC2, PMP22
6	mononeuritis	30.8	MPO, HSPG2, CRP
7	ataxia	30.8	RDPA, SETX, KCND3, SCN2A, SCAR3, MT-ND1
8	peripheral nervous system disease	30.7	APTX, DDC, CSF3, POLG
9	hereditary amyloidosis	30.5	GSN, APOA1, TTR
10	familial transthyretin amyloidosis	30.4	GSN, APOA1, TTR
11	neuropathy	30.4	RETN, CNTF, CNTFR, CNTNAP1, KIF1B, RDPA
12	motor neuritis	30.3	KIF1B, MSN, FGD4, TRPV4, DARC, SH3TC2
13	charcot-marie-tooth disease type 1	30.2	NAB1, CMT1A, MPZ, GJB1, DARC, NTF3
14	hearing loss	30.1	BDNF, MTHFR, MT-ND1, MTR, SACS, MPZ
15	hereditary neuropathies	29.8	LMNA, MPZ, MAG, GJB1, PLP1, NDRG1
16	hereditary neuropathy with liability to pressure palsies	29.8	MPZ, GJB1, SH3TC2, PMP22
17	charcot-marie-tooth disease type 1a	29.8	CMT1A, MPZ, NTF3, PMP22
18	churg-strauss syndrome	29.6	CHKA, AVP, MPO, IL10, IFNA1, IFNG
19	metachromatic leukodystrophy	29.5	ARSA, HEXA, PSAP, GALC
20	leukodystrophy	29.5	MPV17, MPZ, CD40LG, ARSA, MAG, GJA3
21	optic atrophy	29.5	SCAR3, MT-ND1, ATXN3, ATXN2, ATXN1, ARSA
22	refsum disease	29.5	RDPA, SACS, CAT, PHYH, ABHD12, PEX7
23	myoclonus	29.4	SCARB2, SCN2A, ATXN2, INS, MAG, COX5A
24	spastic paraplegia	29.3	SACS, ATXN3, MPZ, CCT4, CCT5, GJA1
25	mononeuropathy	29.2	MPO, SH3TC2, TTR, PMP22
26	hereditary ataxia	29.2	ATXN3, ATXN2, ATXN1, MPZ, GJB1, C10orf2
27	foot drop	29.1	MPZ, TNF, PMP22
28	tremor	29.0	SETX, MTHFR, ATXN2, MPZ, ARSA, GSTP1
29	dysautonomia	29.0	BDNF, HSPG2, NTRK1, NGF, PRNP, AAAS
30	ataxia with isolated vitamin e deficiency	28.9	SETX, APTX, TTPA
31	axonal neuropathy	28.7	KIF1B, VPS13A, SETX, LMNA, SBF2, SACS
32	intestinal pseudo-obstruction	28.6	ALB, TNF, TYMP, SOX10, POLG
33	cerebellar ataxia	28.4	RDPA, SETX, SACS, ATXN3, ATXN2, ATXN1
34	autonomic neuropathy	28.4	INS, CCT5, ALB, AKR1B1, SPTLC2, SPTLC1
35	pancytopenia	28.4	IL3, IFNG, ACE, CSF3, CP, AFP
36	carpal tunnel syndrome	28.3	VEGFA, INS, IL6, SH3TC2, ELN, TTR
37	guillain-barre syndrome	28.3	MPZ, CD40LG, IL10, APOE, IFNG, TNF
38	hemochromatosis	28.2	MT-CYB, MPO, CDAN1, INS, GSTP1, IL6
39	amyloidosis	28.0	ATXN1, CD40LG, INS, GSN, IL3, IL6
40	cryoglobulinemia	27.8	SELE, CD40LG, IL10, IGHM, IFNA1, IFNG
41	type 2 diabetes mellitus	27.7	RETN, SELE, LMNA, MTHFR, MT-ND1, INS
42	hepatitis b	27.7	IL10, IFNA1, IFNG, ALB, CAT, TGFB1
43	thymoma	27.6	KCND3, MPO, IFNA1, IFNG, DMPK, NTRK1
44	hepatitis c	27.6	CD40LG, IL10, IFNA1, IFNG, TNF, ABCB4
45	poems syndrome	27.4	VEGFA, IL6, ALB, TNF, CRP, CSF3
46	muscular dystrophy	27.3	VEGFA, LMNA, MYOT, LIF, CHKA, MT-CYB
47	diphtheria	27.3	CNTF, VEGFA, LIF, CD40LG, ITIH4, IL3
48	macroglobulinemia	26.5	VEGFA, CD40LG, IL10, IL6, MAG, IGHM
49	neuritis	26.3	MT-CO3, MT-ND1, MT-ND2, MPO, MPZ, CD40LG
50	headache	25.9	SELE, BDNF, MTHFR, CD40LG, INS, IL6

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to peripheral neuropathy:

²²

FMA organs/tissues related to peripheral neuropathy:

¹¹

MGI Mouse Phenotypes related to peripheral neuropathy:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system phenotype	MP:0005370	INF	RETN, VEGFA, LIF, CHKA, ATXN2, MPV17
2	cellular phenotype	MP:0005384	INF	CNTF, SELE, NAB2, NAB1, VEGFA, LMNA
3	behavior/neurological phenotype	MP:0005386	INF	CNTF, CNTFR, CNTNAP1, KIF1B, VPS13A, SELE
4	hematopoietic system phenotype	MP:0005397	10.3	CNTF, VPS13A, MPV17, FLVCR1, ARSA, GSN
5	embryogenesis phenotype	MP:0005380	10.2	MFN2, GJB2, GJB3, GJB5, GJC1, TNRC6A
6	no phenotypic analysis	MP:0003012	10.1	VEGFA, MYOT, BDNF, SCN10A, MTHFR, INS
7	endocrine/exocrine gland phenotype	MP:0005379	10.1	ATXN2, CD40LG, GSN, MANBA, IFNG, GJA1
8	hearing/vestibular/ear phenotype	MP:0005377	10.0	LMNA, BDNF, SCARB2, MPV17, ARSA, APOE
9	integument phenotype	MP:0010771	9.4	KIF1B, NAB2, NAB1, LIF, BDNF, SCN10A
10	limbs/digits/tail phenotype	MP:0005371	9.3	VEGFA, LMNA, MTHFR, FLVCR1, IL10, APOE
11	skeleton phenotype	MP:0005390	9.0	KIF1B, NAB2, NAB1, VEGFA, LMNA, LIF
12	adipose tissue phenotype	MP:0005375	8.6	RETN, LMNA, LIF, ATXN2, MPV17, INS
13	normal phenotype	MP:0002873	7.9	SELE, NAB2, NAB1, VEGFA, LMNA, MYOT
14	vision/eye phenotype	MP:0005391	7.2	CNTNAP1, SELE, SERPINF1, VEGFA, LMNA, LIF
15	cardiovascular system phenotype	MP:0005385	INF	SELE, SERPINF1, VEGFA, LMNA, LIF, CLDN5
16	digestive/alimentary phenotype	MP:0005381	INF	SERPINF1, VEGFA, LMNA, LIF, BDNF, ITGB3
17	muscle phenotype	MP:0005369	INF	CNTF, CNTNAP1, KIF1B, VEGFA, LMNA, LIF
18	respiratory system phenotype	MP:0005388	INF	KIF1B, NAB2, NAB1, LIF, BDNF, SCN10A
19	homeostasis/metabolism phenotype	MP:0005376	INF	RETN, CNTF, SELE, VEGFA, LMNA, BDNF
20	immune system phenotype	MP:0005387	INF	CNTF, LMNA, MT-ND2, MPZ, FLVCR1, ARSA
21	nervous system phenotype	MP:0003631	INF	CNTF, CNTFR, CNTNAP1, KIF1B, VPS13A, SERPINF1
22	growth/size phenotype	MP:0005378	INF	CNTNAP1, SELE, NAB2, NAB1, LMNA, LIF
23	reproductive system phenotype	MP:0005389	INF	CNTNAP1, SERPINF1, NAB2, NAB1, VEGFA, LMNA
24	other phenotype	MP:0005395	INF	CD40LG, ITGB3, APOE, HSPG2, GJA1,
25	mortality/aging	MP:0010768	INF	CNTFR, CNTNAP1, KIF1B, SELE, NAB2, NAB1
26	renal/urinary system phenotype	MP:0005367	INF	LMNA, SCARB2, AVP, MPV17, FLVCR1, INS

Articles related to peripheral neuropathy:

(show top 50)    (show all 165)

id	Title	Authors	Year	Affiliating Genes
1	Mutation of SCARB2 in a patient with progressive myoclonus epilepsy and demyelinating peripheral neuropathy. (21670406)	Dibbens L.M.... Berkovic S.F.	2011	SCARB2
2	Peripheral neuropathy is linked to a severe form of m yotonic dystrophy in transgenic mice. (21760538)	Panaite P.A.... Barakat-Walter I.	2011	DMPK
3	Transforming growth factor beta 1 as a biomarker of d iabetic peripheral neuropathy: cross-sectional study. (19796969)	Ybarra J.... Jurado J.	2010	TGFB1
4	Peripheral neuropathy in chronic obstructive pulmonar y disease. (20214459)	Oncel C.... Evyapan F.	2010	TNF, IL6, CRP
5	Peripheral neuropathy and 46XY gonadal dysgenesis: a heterogeneous entity. (19167223)	Baets J.... Jonghe P.D.	2009	MFN2
6	Peripheral neuropathies due to mitochondrial disorde rs (19942242)	Funalot B.	2009	MFN2, POLG, TYMP
7	Peripheral neuropathy and blood-nerve barrier (20030260)	Kanda T.	2009	BDNF, NGF, GDNF
8	Late-onset Tay-Sachs disease: the spectrum of peripheral neuropathy in 30 affected patients. (18642377)	Shapiro B.E.... Pastores G.M.	2008	HEXA
9	Pancytopenia complicated with peripheral neuropathy d ue to copper deficiency: clinical diagnostic review. (19043262)	Imataki O.... Tanaka T.	2008	CP
10	The mitochondrial pharmacogenomics of haplogroup T: MTND2*LHON4917G and antiretroviral therapy-associated peripheral neuropathy. (17684475)	Canter J.A.... Hulgan T.	2008	MT-ND2, MT-ND1
11	Peripheral neuropathy in the twitcher mouse: accumulation of extracellular matrix in the endoneurium and aberrant expression of ion channels. (18172657)	Kagitani-Shimono K.... Suzuki K.	2008	GALC
12	Stratified analyses for selecting appropriate target patients with diabetic peripheral neuropathy for long-term treatment with an aldose reductase inhibitor, epalrestat. (18644069)	Hotta N.... Shigeta Y.	2008	AKR1B1
13	Hereditary amyloidosis with progressive peripheral neuropathy associated with apolipoprotein AI Gly26Arg: outcome of hepatorenal transplantation. (17600344)	Testro A.G.... Angus P.W.	2007	APOA1
14	Therapeutic angiogenesis inhibits or rescues chemothe rapy-induced peripheral neuropathy: taxol- and thalidomide-induced injury of va sa nervorum is ameliorated by VEGF. (17164777)	Kirchmair R.... Losordo D.W.	2007	VEGFA
15	Acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy: a short review. (17696592)	De Grandis D.	2007	GRM2
16	Association of ABCB1 genotypes with paclitaxel-mediated peripheral neuropathy and neutropenia. (16950614)	Sissung T.M.... Mielke S.	2006	ABCB1
17	Peripheral neuropathies in Waldenstrom's macroglobulinaemia. (16421127)	Levine T.... Choksi R.	2006	CD40LG, MAG
18	Peripheral neuropathy in type 2 diabetes mellitus in Isfahan, Iran: prevalence and risk factors. (17083338)	Janghorbani M.... Amini M.	2006	INS
19	Small heat shock proteins in inherited peripheral neuropathies. (16203614)	Dierick I.... Timmerman V.	2005	HSPB8
20	Peripheral neuropathy in metachromatic leucodystrophy. A study of 40 cases from south India. (16291896)	Bindu P.S.... Shankar S.K.	2005	ARSA
21	Distinct disease mechanisms in peripheral neuropathies due to altered peripheral myelin protein 22 gene dosage or a Pmp22 point mutation. (15755691)	Giambonini-Brugnoli G.... Mantei N.	2005	PMP22
22	Peripheral neuropathy in systemic vasculitides. (15604903)	Pagnoux C.... Guillevin L.	2005	MPO
23	Niemann-Pick type C disease associated with peripheral neuropathy. (14629910)	Zafeiriou D.I.... Michelakaki E.	2003	NPC1, NPC2
24	A transthyretin mutation (Tyr78Phe) associated with peripheral neuropathy, carpal tunnel syndrome and skin amyloidosis. (12762139)	Magy N.... Benson M.D.	2003	TTR
25	Peripheral neuropathy during a second cycle of treatment with high doses of interferon-alpha in a patient with hepatitis C, and a review of the literature (12389150)	TAcllez-Zenteno J.F.... GarcA-a-Ramos G.	2002	IFNA1
26	Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies. (12030330)	Venken K.... Svaren J.	2002	EGR2, NAB1, NAB2
27	Clinicopathological studies of peripheral neuropathy in Churg-Strauss syndrome. (12564771)	Nagashima T.... Nagashima K.	2002	CHKA, RNASE3
28	Polyol pathway and diabetic peripheral neuropathy. (12198816)	Oates P.J.	2002	SORD
29	Caspr1/Paranodin/Neurexin IV is most likely not a common disease-causing gene for inherited peripheral neuropathies. (11496158)	Venken K.... Timmerman V.	2001	CNTNAP1
30	A novel SURF1 mutation results in Leigh syndrome with peripheral neuropathy caused by cytochrome c oxidase deficiency. (10899453)	Santoro L.... Santorelli F.M.	2000	SURF1
31	Peripheral neuropathy caused by proteolipid protein gene mutations. (10586260)	Garbern J.Y.... Kamholz J.	1999	PLP1
32	Impaired intracellular trafficking is a common disease mechanism of PMP22 point mutations in peripheral neuropathies. (10078969)	Naef R.... Suter U.	1999	PMP22
33	Molecular genetics and biology of inherited peripheral neuropathies: a fast-moving field. (10541586)	Nelis E.... Rautenstrauss B.	1999	GJB1, PMP22, MPZ
34	Expression of glial cell line-derived neurotrophic factor and GDNFR-alpha mRNAs in human peripheral neuropathies. (9853108)	Yamamoto M.... Sobue G.	1998	GFRA1
35	Peripheral neuropathy and lipid-lowering therapy. (9671841)	Ziajka P.E.... Wehmeier T.	1998	HMGCR
36	Gene dosage effects in hereditary peripheral neuropathy. Expression of peripheral myelin protein 22 in Charcot-Marie-Tooth disease type 1A and hereditary neuropathy with liability to pressure palsies nerve biopsies. (9409359)	Gabriel J.M.... Steck A.J.	1997	PMP22
37	Inherited demyelinating peripheral neuropathies: relating myelin packing abnormalities to P0 molecular defects. (8950710)	Kirschner D.A.... Bolhuis P.A.	1996	MPZ
38	Fatal vascular leak syndrome with extensive hemorrhage, peripheral neuropathy and reactive erythrophagocytosis: an unusual complication of recombinant IL-3 therapy. (8624477)	Hurwitz N.... Gratwohl A.	1996	IL3
39	Tolrestat in the therapy of diabetic peripheral neuropathy: is this drug really useful? (8681499)	Daniele E.... Coco M.P.	1995	AKR1B1
40	Effect of 24 weeks of treatment with epalrestat, an aldose reductase inhibitor, on peripheral neuropathy in patients with non-insulin-dependent diabetes mellitus. (7585850)	Uchida K.... Morimoto S.	1995	AKR1B1
41	Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant alpha-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study). (8786016)	Ziegler D.... Gries F.A.	1995	AAAS
42	Neurotrophic factors in the therapy of peripheral neuropathy. (8599726)	Apfel S.C.... Kessler J.A.	1995	BDNF, NTF3, NGF
43	Human beta-mannosidase deficiency associated with peripheral neuropathy. (8285582)	Levade T.... Salvayre R.	1994	MANBA
44	The clinical spectrum and pathogenesis of HIV encephalopathy, myelopathy, and peripheral neuropathy. (8081514)	Brew B.J.	1994	ITIH4
45	Genetic basis of inherited peripheral neuropathies. (7515304)	Suter U.... Patel P.I.	1994	MPZ, CMT1A
46	Peripheral neuropathy as the presenting feature of tyrosinaemia type I and effectively treated with an inhibitor of 4-hydroxyphenylpyruvate dioxygenase. (8410015)	Gibbs T.C.... Clayton P.T.	1993	FAH, HPD
47	Elevated plasma insulin-like growth factor binding protein-1 levels in type 1 (insulin-dependent) diabetic patients with peripheral neuropathy. (1383070)	Crosby S.R.... White A.	1992	IGFBP1
48	Chronic hexosaminidase A deficiency associated with pure sensory peripheral neuropathy (1302293)	Sica R.E.... Arbera C.	1992	HEXA
49	Cloning and sequence analysis of the VH and VL regions of an anti-myelin/DNA antibody from a patient with peripheral neuropathy and chronic lymphocytic leukemia. (2156935)	Spatz L.A.... Latov N.	1990	IGHM
50	Ataxia and peripheral neuropathy: a benign variant of peroxisome dysgenesis. (2178332)	MacCollin M.... Beard M.	1990	CAT

Genes related to peripheral neuropathy according to GeneCards:

(show top 50)    (show all 191)

id	Symbol	Description	Score	GeneCards Section Context
1	SLC12A6	solute carrier family 12 (potassium/chloride transporters), member 6	11.1	Aliases & Descriptions, Summaries, Publications
2	GJB1	gap junction protein, beta 1, 32kDa	11.1	Publications, Summaries
3	GJB3	gap junction protein, beta 3, 31kDa	11.1	Summaries
4	GJE1	gap junction protein, epsilon 1, 23kDa	11.1	Summaries
5	GJD3	gap junction protein, delta 3, 31.9kDa	11.1	Summaries
6	GJA10	gap junction protein, alpha 10, 62kDa	11.1	Summaries
7	GJB5	gap junction protein, beta 5, 31.1kDa	11.1	Summaries
8	GJC3	gap junction protein, gamma 3, 30.2kDa	11.1	Summaries
9	GJD4	gap junction protein, delta 4, 40.1kDa	11.1	Summaries
10	GJA9	gap junction protein, alpha 9, 59kDa	11.1	Summaries
11	GJB4	gap junction protein, beta 4, 30.3kDa	11.1	Summaries
12	GJA8	gap junction protein, alpha 8, 50kDa	11.1	Summaries
13	GJD2	gap junction protein, delta 2, 36kDa	11.1	Summaries
14	GJC2	gap junction protein, gamma 2, 47kDa	11.1	Summaries
15	GJA3	gap junction protein, alpha 3, 46kDa	11.1	Summaries
16	GJA4	gap junction protein, alpha 4, 37kDa	11.1	Summaries
17	SCARB2	scavenger receptor class B, member 2	11.1	Publications, Summaries
18	GJA5	gap junction protein, alpha 5, 40kDa	11.1	Summaries
19	GJC1	gap junction protein, gamma 1, 45kDa	11.1	Summaries
20	GJB7	gap junction protein, beta 7, 25kDa	11.1	Summaries
21	GJB6	gap junction protein, beta 6, 30kDa	11.1	Summaries
22	ATXN2	ataxin 2	11.1	Summaries
23	GJA1	gap junction protein, alpha 1, 43kDa	11.1	Summaries
24	SACS	spastic ataxia of Charlevoix-Saguenay (sacsin)	11.1	Summaries
25	GJB2	gap junction protein, beta 2, 26kDa	11.1	Summaries
26	PMP22	peripheral myelin protein 22	11.0	Publications
27	MPZ	myelin protein zero	11.0	Publications
28	EGR2	early growth response 2	11.0	Publications
29	SCN10A	sodium channel, voltage-gated, type X, alpha subunit	11.0	Summaries
30	CMT1A	Charcot-Marie-Tooth neuropathy 1A (greatly reduced nerve conduction velocity, hereditary motor sensory neuropathy Ia)	11.0	Publications
31	PRPS1L1	phosphoribosyl pyrophosphate synthetase 1-like 1	11.0	Publications
32	CNTNAP1	contactin associated protein 1	11.0	Publications
33	PLEKHG4	pleckstrin homology domain containing, family G (with RhoGef domain) member 4	11.0
34	PRPS1	phosphoribosyl pyrophosphate synthetase 1	11.0	Publications
35	HSPB8	heat shock 22kDa protein 8	11.0	Publications
36	FLVCR1	feline leukemia virus subgroup C cellular receptor 1	11.0
37	SH3TC2	SH3 domain and tetratricopeptide repeats 2	11.0	Publications
38	HEXA	hexosaminidase A (alpha polypeptide)	11.0	Publications
39	NDRG4	NDRG family member 4	11.0
40	NDRG3	NDRG family member 3	11.0
41	DARC	Duffy blood group, chemokine receptor	11.0
42	NDRG1	N-myc downstream regulated 1	11.0
43	MSN	moesin	11.0
44	FGD4	FYVE, RhoGEF and PH domain containing 4	11.0
45	NUMB	numb homolog (Drosophila)	11.0
46	KIF1B	kinesin family member 1B	11.0
47	TNRC6A	trinucleotide repeat containing 6A	11.0
48	ELAVL4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4	11.0
49	CCT4	chaperonin containing TCP1, subunit 4 (delta)	11.0
50	TRPV4	transient receptor potential cation channel, subfamily V, member 4	11.0

Pathways related to peripheral neuropathy according to GeneDecks:

(show all 30)

id	Pathway	Score	Top Affiliating Genes
1	Signaling in Gap Junctions36	11.7	GRM2, GJE1, GJD2, GJC1, GJB7, GJB6
2	Cell adhesion Gap junctions10	11.3	PRKCB, GJD2, GJC1, GJB3, GJB2, GJB1
3	Cell adhesion_Gap junctions41	11.3	GJB3, GJC1, GJD2, PRKCB, GJB2, GJB1
4	Oligomerization of connexins into connexons38	10.9	GJA1, GJB1, GJB2
5	Angiogenesis3	10.6	TGFB1, TYMP, NDRG4, NDRG3, NDRG2, NDRG1
6	Lysosome20	10.6	GALC, NPC2, NPC1, PSAP, HEXA, MANBA
7	Development MAG-dependent inhibition of neurite outgrowth10	10.2	NGF, NTRK3, NTRK1, NTF4, NTF3, MAG
8	Development_MAG-dependent inhibition of neurite outgrowth41	10.2	NGF, NTRK3, NTRK1, NTF4, NTF3, MAG
9	Development_Neurotrophin family signaling41	10.1	NTF3, NTF4, NTRK1, NTRK3, NGF, BDNF
10	Development Neurotrophin family signaling10	10.1	NGF, BDNF, NTF3, NTF4, NTRK1, NTRK3
11	Jak-STAT signaling pathway20	10.1	CNTF, CNTFR, IL10, IL3, IFNA1
12	Neuroscience3	9.8	WFS1, NEFL, NUMB, NDRG1, NGF, NTRK3
13	Platinum Pathway, Pharmacokinetics/Pharmacodynamics34	9.6	GSTT1, GSTP1, GSTM1, MPO
14	Etoposide Pathway, Pharmacokinetics/Pharmacodynamics34	9.5	ABCB1, GSTT1, GSTP1, MPO
15	Intestinal immune network for IgA production20	9.4	CXCR4, CXCL12, TGFB1, IL6, IL10, CD40LG
16	Asthma20	9.3	RNASE3, TNF, IL3, IL10, CD40LG
17	Metabolic pathways20	9.3	DPYD, TYMP, HEXA, COX5A, RPIA, SPTLC1
18	Hypertrophic cardiomyopathy (HCM)20	9.0	DES, TGFB1, ACE, TNF, CACNA2D1, IL6
19	Rho Family GTPases36	8.8	NTRK3, ELN, TGFB1, DES, CXCL12, CSF3
20	African trypanosomiasis20	8.5	PRKCB, TNF, IFNG, APOA1, IL6, IL10
21	PEDF Induced Signaling36	8.5	GDNF, CSF3, CXCL12, TNF, IL6, IL3
22	Cytokine Network36	8.4	TNF, IFNG, IFNA1, IL6, IL3, IL10
23	Apoptotic Pathways in Synovial Fibroblasts36	8.3	CXCL12, TGFB1, NTRK3, NTRK1, NTF3, TNF
24	PPAR Pathway36	8.3	CXCL12, NTRK3, NTRK1, NTF3, TNF, IL6
25	Malaria20	8.3	CSF3, TGFB1, DARC, TNF, IFNG, IL6
26	Cellular Apoptosis Pathway36	8.2	CXCL12, PRPS1, TGFB1, NTRK3, NTRK1, NTF3
27	PAK Pathway36	7.5	CSF3, CXCL12, TGFB1, NTRK3, NTF3, TNF
28	Cytokine-cytokine receptor interaction20	7.0	IFNG, TNF, TGFB1, CXCL12, CXCR4, CSF3
29	Selected targets of HNF110	INF	, CRP, GJB1, ALB, IGFBP1, APOA1
30	Selected targets of CREB110	INF	PDYN, HMGCR, INS, LIF,

Compounds related to peripheral neuropathy according to GeneDecks:

(show top 50)    (show all 300)

id	Compound	Score	Top Affiliating Genes
1	atp32	INF	PC, LMNA, LIF, BDNF, CHKA, YARS
2	gap 2642	11.9	GJA1, GJA10, GJA3, GJA4, GJA5, GJA8
3	gap 2742	11.9	GJA1, GJA10, GJA3, GJA4, GJA5, GJA8
4	ganglioside32	10.7	CNTF, MPZ, ITIH4, ARSA, MAG, NTF3
5	glucose32	10.4	CNTF, PC, SERPINF1, MT-CO3, MT-CYB, MT-ND1
6	n acetylcysteine32	9.8	SELE, BDNF, IL3, APOE, HMGCR, PLP1
7	arginine32	9.7	CNTF, LIF, AVP, MSN, KARS, MPZ
8	aspartate32	9.5	RETN, PC, BDNF, MT-CYB, MPZ, CD40LG
9	dopamine32 9 18 9	12.5	CNTF, SELE, LIF, BDNF, MTHFR, CD40LG
10	vitamin b1232	9.4	MTHFR, MTR, MPO, CD40LG, APOA1, APOE
11	ascorbic acid32 18	10.2	CNTF, LIF, BDNF, CHKA, MT-CYB, CD40LG
12	epinephrine32 9 18 9	12.2	SELE, BDNF, INS, IGFBP1, AKR1B1, HMGCR
13	acetylcholine32 9 18 9	12.1	CNTF, CNTFR, LIF, BDNF, CHKA, MPO
14	uric acid32 18	10.1	RETN, CHKA, MTHFR, AVP, INS, APOA1
15	h2o232	9.1	CNTF, LIF, BDNF, MT-CYB, MPO, ITIH4
16	norepinephrine32 9 18 9	11.9	RETN, CNTF, SELE, LIF, BDNF, AVP
17	adenylate32	8.7	CNTF, SELE, BDNF, CHKA, CD40LG, ITIH4
18	estrogen32	8.7	RETN, BDNF, CHKA, MTHFR, MTR, MSN
19	iron32 18	9.4	BDNF, MT-CYB, MT-ND1, MT-ND2, MPO, CDAN1
20	histamine32 18	9.3	CNTF, SELE, BDNF, MPO, CD40LG, IL3
21	heparin32 9 18 9	11.3	SERPINF1, LIF, MPO, ITIH4, GSN, IL3
22	valine32	8.2	BDNF, MTHFR, MT-ND1, MTR, MT-ND2, MPO
23	paraffin32	8.2	VEGFA, LIF, CHKA, MPO, CD40LG, ITIH4
24	cysteine32	8.1	SERPINF1, LIF, MTHFR, MTR, AVP, ATXN3
25	creatinine32	7.2	RETN, VPS13A, SELE, LMNA, BDNF, CHKA
26	indomethacin32 9 9	8.9	BDNF, MPO, CD40LG, ITIH4, IL6, APOA1
27	alanine32	6.8	RETN, CNTF, PC, SELE, LMNA, SCARB2
28	vegf32	6.8	RETN, CNTF, SELE, SERPINF1, NAB2, LIF
29	thymidine32 18	7.7	CNTF, LIF, BDNF, CHKA, MTHFR, MT-CYB
30	methotrexate32 34 42 9 9	10.0	SELE, MTHFR, MTR, GSTM1, GSTP1, IL10
31	actinomycin d32	5.9	RETN, CNTF, SELE, VEGFA, LIF, BDNF
32	lactate32	5.8	PC, SELE, LIF, BDNF, CHKA, MT-ND1
33	lipid32	INF	RETN, CNTF, CNTFR, PC, SELE, LMNA
34	nitric oxide32 9 18 9	INF	RETN, CNTF, SELE, SERPINF1, LIF, MT-CYB
35	testosterone32 9 18 9	INF	CNTF, SELE, LIF, BDNF, CHKA, MTHFR
36	dexamethasone32 42 34 9 9	INF	RETN, PC, SERPINF1, VEGFA, LIF, CHKA
37	cycloheximide32	INF	RETN, CNTF, SELE, VEGFA, LIF, BDNF
38	choline32 9 18 9	INF	CNTF, LIF, BDNF, CHKA, MTHFR, IL3
39	serine32	INF	CNTF, SELE, SERPINF1, LMNA, LIF, BDNF
40	alpha tocopherol32	INF	SETX, LIF, CHKA, MTHFR, GSTM1, APOA1
41	tyrosine32	INF	RETN, CNTF, CNTNAP1, SERPINF1, VEGFA, LIF
42	aspirin32 34 18	INF	SELE, MTHFR, CD40LG, ITGB3, GSTP1, APOA1
43	retinoic acid32 42 18	INF	CNTF, CNTFR, SERPINF1, LMNA, LIF, BDNF
44	fibrinogen32	INF	RETN, SELE, LIF, CD40LG, ITGB3, INS
45	genistein32 9 18 9	INF	CNTF, SELE, VEGFA, LIF, CHKA, CD40LG
46	glutamate32	INF	PC, SERPINF1, CHKA, MTHFR, MTR, KARS
47	cyclosporin a32 42	INF	LIF, MTHFR, ITIH4, IL10, IL3, APOE
48	cholesterol32 9 18 9	INF	RETN, SELE, LMNA, LIF, BDNF, SCARB2
49	oxygen32 18	INF	SERPINF1, LIF, BDNF, CHKA, MT-CYB, MTR
50	methionine32	INF	CNTF, SERPINF1, LIF, BDNF, MTHFR, MT-ND1

Cellular components related to peripheral neuropathy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	connexon complex	GO:005922	11.6	GJA1, GJB6, GJB7, GJC1, GJC2, GJC3
2	gap junction	GO:005921	10.7	GJD2, GJC1, GJB4, GJB3, GJA5, GJA4
3	extracellular region	GO:005576	6.1	PDYN, RNASE3, NGF, CRP, NTF4, NTF3
4	extracellular space	GO:005615	4.9	NGF, CRP, TNF, AKR1B1, HSPG2, ALB
5	cytosol	GO:005829	INF	TYMP, NDRG4, NDRG2, NDRG1, RPIA, DDC

Biological processes related to peripheral neuropathy according to GeneDecks:

(show all 24)

id	Name	GO ID	Score	Top Affiliating Genes
1	cell communication	GO:007154	11.4	GJE1, GJD4, GJD3, GJD2, GJB7, GJB6
2	gap junction assembly	GO:016264	11.1	GJD3, GJC1, GJB2, GJB1, GJA1
3	cell-cell junction assembly	GO:007043	10.9	GJA4, GJA5, GJC1, TRPV4
4	peripheral nervous system development	GO:007422	10.8	PMP22, SOX10, EGR2, NGF, NTF3
5	cell-cell signaling	GO:007267	10.6	ADRA2B, NTF3, GJC2, GJB2, GJB1, GJA5
6	mechanoreceptor differentiation	GO:042490	10.6	NTRK1, NTF4, NTF3, BDNF
7	negative regulation of neuron apoptotic process	GO:043524	10.5	GDNF, WFS1, NGF, NTRK1, NTF3, BDNF
8	organ regeneration	GO:031100	10.2	AFP, CXCL12, PRPS1, TGFB1, HMBS, LIF
9	nervous system development	GO:007399	9.7	NTF3, NTRK3, NDRG2, ELAVL3, PRPS1, GDNF
10	negative regulation of lipid storage	GO:010888	9.2	CRP, TNF, IL6, ITGB3
11	negative regulation of cytokine secretion involved in immune response	GO:002740	9.1	IL10, APOA1, TNF
12	positive regulation of peptidyl-serine phosphorylation	GO:033138	8.8	TGFB1, TNF, IL6, AVP, LIF, VEGFA
13	platelet activation	GO:030168	8.7	ADRA2B, PRKCB, PSAP, TGFB1, ALB, APOA1
14	anti-apoptosis	GO:006916	8.6	GDNF, PRNP, NGF, TNF, APOE, IL10
15	negative regulation of apoptotic process	GO:043066	7.6	WFS1, RRM2B, SOX10, CXCL12, TNF, CAT
16	transport	GO:006810	INF	GJC1, , ABCB1, ABCB4, TTPA, TTR
17	cell death	GO:008219	INF	, , PLP1, PDYN, C10orf2, HEXA
18	myelination	GO:042552	INF	, TGFB1, HEXA, EGR2, NTF3, GJC3
19	lipid metabolic process	GO:006629	INF	TTPA, ABCB4, , HSPG2, ALB, APOE
20	Cdc42 protein signal transduction	GO:032488	INF	, APOE, APOA1
21	small molecule metabolic process	GO:044281	INF	ABCB4, ABCB1, , PHYH, COX5A, RPIA
22	cholesterol metabolic process	GO:008203	INF	NPC2, NPC1, , CAT, APOE, APOA1
23	cholesterol efflux	GO:033344	INF	NPC2, NPC1, , APOE, APOA1
24	high-density lipoprotein particle assembly	GO:034380	INF	APOA1, APOE,

Molecular functions related to peripheral neuropathy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	gap junction channel activity	GO:005243	11.1	GJA1, GJD2, GJC2, GJB4, GJB3, GJB2
2	identical protein binding	GO:042802	9.3	SOX10, PRNP, TNF, GJA3, HSPB8, ALAD
3	growth factor activity	GO:008083	8.3	NGF, TYMP, TGFB1, CXCL12, CSF3, GDNF
4	cytokine activity	GO:005125	7.3	CSF3, TNF, IFNG, IL6, IL3, IL10
5	cholesterol binding	GO:015485	INF	NPC2, NPC1, , CRP, APOA1