MCID: PRP023
MIFTS: 52

Peripheral Neuropathy malady

Neuronal diseases, Rare diseases categories
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Summaries for Peripheral Neuropathy

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Sources:
8Disease Ontology, 44NINDS, 65Wikipedia, 33MalaCards
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NINDS:44 Peripheral neuropathy describes damage to the peripheral nervous system, which transmits information from the brain and spinal cord to every other part of the body.

MalaCards: Peripheral Neuropathy is related to neuropathy and sensory peripheral neuropathy. An important gene associated with Peripheral Neuropathy is SLC12A6 (solute carrier family 12 (potassium/chloride transporter), member 6), and among its related pathways are Potassium transporters inward current and Cell adhesion Endothelial cell contacts by junctional mechanisms. The compounds scrambled 10panx and carbenoxolone disodium have been mentioned in the context of this disorder. Affiliated tissues include nerves of the peripheral nervous system, spinal cord and brain, and related mouse phenotypes are no phenotypic analysis and nervous system.

Disease Ontology:8 A neuropathy that is located in nerves of the peripheral nervous system.

Wikipedia:65 Peripheral neuropathy (PN) is damage or disease affecting nerves, which may impair sensation, movement,... more...

Aliases & Classifications for Peripheral Neuropathy

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Sources:
8Disease Ontology, 44NINDS, 10DISEASES, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

peripheral neuropathy 8 44 10 62


External Ids:

Disease Ontology8 DOID:0060053

Related Diseases for Peripheral Neuropathy

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Peripheral Neuropathy family:

Inherited Peripheral Neuropathy

Diseases related to Peripheral Neuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 421)
idRelated DiseaseScoreTop Affiliating Genes
1neuropathy32.2GJB1
2sensory peripheral neuropathy30.9SLC12A6, GJB1
3charcot-marie-tooth disease30.6GJC3, GJB1
4cataract29.9GJA3, GJA8
5diabetes mellitus10.6
6inherited peripheral neuropathy10.5
7myeloma10.5
8ataxia10.5
9type 2 diabetes mellitus10.5
10cryoglobulinemia10.5
11multiple myeloma10.5
12blindness10.5
13postherpetic neuralgia10.4
14spasticity10.4
15neuronitis10.4
16leukemia10.4
17churg-strauss syndrome10.4
18tooth disease10.4
19motor peripheral neuropathy10.4
20breast cancer10.4
21hepatitis10.4
22autonomic neuropathy10.3
23optic atrophy10.3
24cervical hypertrichosis peripheral neuropathy10.3
25autonomic peripheral neuropathy10.3
26osteosclerotic myeloma10.3
27metachromatic leukodystrophy10.3
28olivopontocerebellar atrophy10.3
29systemic lupus erythematosus10.3
30amyloidosis10.3
31cerebellar ataxia10.3
32colorectal cancer10.3
33dementia10.3
34leukodystrophy10.3
35lupus erythematosus10.3
36paraplegia10.3
37porphyria10.3
38autosomal dominant optic atrophy, hearing loss, and peripheral neuropathy10.3
39autosomal recessive optic atrophy, hearing loss, and peripheral neuropathy10.3
40spastic paraparesis10.3
41peripheral neuropathy, myopathy, hoarseness, and hearing loss10.3
42hepatitis c10.2
43chediak-higashi syndrome10.2
44hereditary spastic paraplegia10.2
45krabbe disease10.2
46cerebrotendinous xanthomatosis10.2
47poems syndrome10.2
48mononeuritis10.2
49myopathy10.2
50myotonic dystrophy10.2

Graphical network of the top 20 diseases related to Peripheral Neuropathy:



Diseases related to peripheral neuropathy

Symptoms for Peripheral Neuropathy

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Drugs & Therapeutics for Peripheral Neuropathy

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Peripheral Neuropathy

Search NIH Clinical Center for Peripheral Neuropathy

Genetic Tests for Peripheral Neuropathy

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Anatomical Context for Peripheral Neuropathy

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33MalaCards, 14FMA
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MalaCards organs/tissues related to Peripheral Neuropathy:

33
Spinal cord, Brain, Breast, Testes, Skin, T cells, Endothelial, Colon, Heart, Lung, Monocytes, B cells, Amygdala, Pituitary, Thyroid, Liver, Kidney, Skeletal muscle, Lymph node, Whole blood, Bone, Eye, Bone marrow

FMA organs/tissues related to Peripheral Neuropathy:

14
Nerves of the peripheral nervous system

Animal Models for Peripheral Neuropathy or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Peripheral Neuropathy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.4GJB3, GJD2, GJA5, GJB6
2MP:00036317.8GJC2, GJB6, GJB1, GJD2, GJC3, SLC12A6
3MP:00053917.5SLC12A6, GJC2, GJA8, GJE1, GJB1, GJA3

Publications for Peripheral Neuropathy

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52PubMed
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Articles related to Peripheral Neuropathy:

(show top 50)    (show all 885)
idTitleAuthorsYear
1
The role of oxidative stress and inflammatory response in high-fat diet induced peripheral neuropathy. (24407112)
2014
2
Therapeutic Effects of Fenofibrate on Diabetic Peripheral Neuropathy by Improving Endothelial and Neural Survival in db/db Mice. (24392081)
2014
3
Comparison of two chemotherapy-induced peripheral neuropathy measurement approaches in children. (24072474)
2014
4
Whole body vibration therapy for painful diabetic peripheral neuropathy: a pilot study. (24139013)
2013
5
Phase 1/2 open-label dose-escalation study of plasmid DNA expressing two isoforms of hepatocyte growth factor in patients with painful diabetic peripheral neuropathy. (23609019)
2013
6
Association of thymidylate synthase polymorphisms with acute pancreatitis and/or peripheral neuropathy in HIV-infected patients on stavudine-based therapy. (23468971)
2013
7
The neurology of Sjogren's syndrome and the rheumatology of peripheral neuropathy and myelitis. (24307005)
2013
8
Ruboxistaurin for the treatment of diabetic peripheral neuropathy: a systematic review of randomized clinical trials. (24199167)
2013
9
Divergent effects of T cell costimulation and inflammatory cytokine production on autoimmune peripheral neuropathy provoked by Aire deficiency. (23487421)
2013
10
Association of statin use with peripheral neuropathy in the U.S. population 40 years of age or older. (23121724)
2013
11
Median nerve ultrasound in diabetic peripheral neuropathy with and without carpal tunnel syndrome. (23401087)
2013
12
Evaluation of the clinical efficacy of multiple lower-extremity nerve decompression in diabetic peripheral neuropathy. (23713665)
2013
13
Infantile peripheral neuropathy, deafness, and proximal tubulopathy associated with a novel mutation of the RRM2B gene: case study. (24382854)
2013
14
Manual acupuncture for treatment of diabetic peripheral neuropathy: a systematic review of randomized controlled trials. (24069229)
2013
15
The correlation between pain-related behaviour and spinal microgliosis in four distinct models of peripheral neuropathy. (22467279)
2012
16
The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CBa88 receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy. (22998838)
2012
17
Asymmetric time-dependent activation of right central amygdala neurones in rats with peripheral neuropathy and pregabalin modulation. (22861166)
2012
18
Subclinical peripheral neuropathy is a common finding in colorectal cancer patients prior to chemotherapy. (22496202)
2012
19
Total vascular risk as a strong correlate of severity of diabetic peripheral neuropathy in Nigerian Africans. (22774318)
2012
20
Relation of sensory peripheral neuropathy in SjAPgren syndrome to anti-Ro/SSA. (22955477)
2012
21
Diabetic peripheral neuropathy is highly associated with nontraumatic fractures in Korean patients with type 2 diabetes mellitus. (21906118)
2012
22
Mitotoxicity and bortezomib-induced chronic painful peripheral neuropathy. (22947198)
2012
23
Comparison of different screening tests for diagnosis of diabetic peripheral neuropathy in Primary Health Care setting. (23580893)
2012
24
The prevalence, patterns and predictors of diabetic peripheral neuropathy in a developing country. (22642973)
2012
25
Peripheral neuropathies: Molecular diagnosis of Charcot-Marie-Tooth disease. (21587243)
2011
26
Association of osteonecrosis and peripheral neuropathy in HIV-1-infected patients: possible roles of nerve growth factor and vascular endothelial growth factor. (22067199)
2011
27
Prevalence of peripheral neuropathy in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). (21510232)
2011
28
Hereditary peripheral neuropathies]. (19327944)
2009
29
Prospective study of peripheral neuropathy in Machado-Joseph disease. (19802879)
2009
30
Peripheral neuropathy in a child with Cree leukodystrophy. (17641267)
2007
31
Diagnostic value of autoantibodies to MAG by ELISA BA1hlmann in 117 immune-mediated peripheral neuropathies associated with monoclonal IgM to SGPG/SGLPG]. (16829480)
2006
32
Peripheral neuropathy in CADASIL. (15827866)
2005
33
Peripheral neuropathy in pediatric systemic lupus erythematosus. (12770683)
2003
34
Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled double-blind parallel group study. (11574441)
2001
35
Severe peripheral neuropathy, cardiac hypofunction, and syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in a patient with Churg-Strauss syndrome]. (10614173)
1999
36
Olivopontocerebellar atrophy and peripheral neuropathy--Wadia type. (10999111)
1999
37
Confocal microscopic localization of anti-myelin-associated glycoprotein autoantibodies in a patient with peripheral neuropathy initially lacking a detectable IgM gammopathy. (9600601)
1998
38
The pathogenesis of diffuse infiltrative lymphocytosis syndrome: an AIDS-related peripheral neuropathy. (9566362)
1998
39
Peripheral neuropathy in acrodermatitis chronica atrophicans - a late Borrelia manifestation. (9228267)
1997
40
Correlation between the histopathologic, genotypic, and phenotypic features of hereditary peripheral neuropathies in childhood. (8881991)
1996
41
Demyelinating peripheral neuropathy with Creutzfeldt-Jakob disease and mutation at codon 200 of the prion protein gene. (8780103)
1996
42
Autosomal dominant optic atrophy with asymptomatic peripheral neuropathy. (8708653)
1996
43
Neurotrophic factors in the treatment of peripheral neuropathy. (8866130)
1996
44
TTR exon scanning in peripheral neuropathies. (7633183)
1995
45
Human beta-mannosidase deficiency associated with peripheral neuropathy. (8285582)
1994
46
The clinical spectrum and pathogenesis of HIV encephalopathy, myelopathy, and peripheral neuropathy. (8081514)
1994
47
Peripheral and autonomic nerve function in 259 diabetic patients with peripheral neuropathy treated with ponalrestat (an aldose reductase inhibitor) or placebo for 18 months. United Kingdom/Scandinavian Ponalrestat Trial. (1611136)
1992
48
Clinical and neurophysiological studies of aldose reductase inhibitor ponalrestat in chronic symptomatic diabetic peripheral neuropathy. (1901808)
1991
49
Peripheral neuropathy in cerebrotendinous xanthomatosis. (2994606)
1985
50
Orthopaedic management of childhood neuromuscular disease. Part II: peripheral neuropathies, Friedreich's ataxia, and arthrogryposis multiplex congenita. (6282888)
1982

Variations for Peripheral Neuropathy

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Expression for genes affiliated with Peripheral Neuropathy

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Peripheral Neuropathy

Search GEO for disease gene expression data for Peripheral Neuropathy.

Pathways for genes affiliated with Peripheral Neuropathy

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Sources:
50PathCards, 12EMD Millipore, 60Thomson Reuters, 38NCBI BioSystems Database, 55Reactome, 53QIAGEN, 30KEGG
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Compounds for genes affiliated with Peripheral Neuropathy

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61Tocris Bioscience, 29IUPHAR, 24HMDB, 45Novoseek, 3BitterDB, 11DrugBank
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Compounds related to Peripheral Neuropathy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1scrambled 10panx615.4GJB3, GJC2, GJC3, GJD2, GJB4, GJA3
2carbenoxolone disodium615.4GJC3, GJD2, GJB4, GJA3, GJB1, GJA5
3gap 27615.3GJB3, GJC2, GJC3, GJD2, GJB4, GJA3
4octanol29 246.3GJC3, GJD2, GJB4, GJA3, GJB1, GJA5
5ca2+295.2GJB3, GJC2, GJC3, GJD2, GJB4, GJA3
610panx615.2GJC3, GJD2, GJB4, GJA3, GJB1, GJA5
7flufenamic acid29 45 3 118.1GJC3, GJD2, GJB4, GJA3, GJB1, GJA5
8carbenoxolone45 29 116.9GJB3, GJC2, GJC3, GJD2, GJB4, GJA3

GO Terms for genes affiliated with Peripheral Neuropathy

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16Gene Ontology
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Cellular components related to Peripheral Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1myelin sheathGO:0432099.8GJC3, GJC2
2gap junctionGO:0059219.0GJA4, GJA5, GJB3
3integral component of membraneGO:0160216.7GJC2, GJB6, GJB1, GJA3, GJB4, GJD2
4connexon complexGO:0059225.8GJB3, GJC2, GJB6, GJA4, GJA8, GJA5

Biological processes related to Peripheral Neuropathy according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1gap junction assemblyGO:0162649.7GJB1, GJA5
2potassium ion transportGO:0068139.6SLC12A6, GJA5
3endothelium developmentGO:0031589.4GJA5, GJA4
4protein oligomerizationGO:0512599.3GJB1, GJA5
5visual perceptionGO:0076019.3GJD2, GJA3, GJA8
6sensory perception of soundGO:0076059.1GJB6, GJC3, GJB3
7transportGO:0068109.0GJA4, GJA8, GJB1, GJA3
8cell communicationGO:0071548.9GJB3, GJC3, GJB4, GJB6
9transmembrane transportGO:0550858.8SLC12A6, GJB3, GJD2, GJA5, GJA8
10cell-cell signalingGO:0072678.7GJC2, GJA4, GJA8, GJB1, GJA3

Molecular functions related to Peripheral Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1gap junction channel activityGO:0052438.7GJB3, GJD2, GJA3, GJB1, GJC2

Products for genes affiliated with Peripheral Neuropathy

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  • Antibodies
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Sources for Peripheral Neuropathy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet