MCID: PRP023
MIFTS: 53

Peripheral Neuropathy malady

Neuronal diseases category

Summaries for Peripheral Neuropathy

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Sources:
8Disease Ontology, 43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Peripheral neuropathy describes damage to the peripheral nervous system, which transmits information from the brain and spinal cord to every other part of the body.

MalaCards: Peripheral Neuropathy is related to neuropathy and sensory peripheral neuropathy. An important gene associated with Peripheral Neuropathy is SLC12A6 (solute carrier family 12 (potassium/chloride transporter), member 6), and among its related pathways are Gap junction trafficking and Membrane Trafficking. The compounds gap 27 and carbenoxolone have been mentioned in the context of this disorder. Affiliated tissues include nerves of the peripheral nervous system, spinal cord and brain, and related mouse phenotypes are vision/eye and no phenotypic analysis.

Disease Ontology:8 A neuropathy that is located in nerves of the peripheral nervous system.

Wikipedia:63 Peripheral neuropathy (PN) is damage or disease affecting nerves, which may affect sensation, movement,... more...

Aliases & Classifications for Peripheral Neuropathy

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Sources:
8Disease Ontology, 43NINDS, 10DISEASES, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

peripheral neuropathy 8 43 10 60


External Ids:

Disease Ontology8 DOID:0060053

Related Diseases for Peripheral Neuropathy

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Peripheral Neuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 378)
idRelated DiseaseScoreTop Affiliating Genes
1neuropathy32.0GJB1
2sensory peripheral neuropathy30.9SLC12A6, GJB1
3diabetic neuropathy11.1
4diabetes mellitus10.6
5autonomic peripheral neuropathy10.5
6myeloma10.5
7motor peripheral neuropathy10.5
8autonomic neuropathy10.5
9type 2 diabetes mellitus10.5
10axonal neuropathy10.4
11cryoglobulinemia10.4
12multiple myeloma10.4
13neuronitis10.4
14breast cancer10.4
15charcot-marie-tooth disease10.4
16leukemia10.4
17tooth disease10.4
18churg-strauss syndrome10.4
19diabetic autonomic neuropathy10.3
20hepatitis10.3
21alcoholic neuropathy10.3
22cerebellar ataxia10.3
23optic atrophy10.3
24cervical hypertrichosis peripheral neuropathy10.3
25olivopontocerebellar atrophy10.2
26systemic lupus erythematosus10.2
27metachromatic leukodystrophy10.2
28osteosclerotic myeloma10.2
29acute porphyria10.2
30amyloidosis10.2
31dementia10.2
32leukodystrophy10.2
33lupus erythematosus10.2
34paraplegia10.2
35porphyria10.2
36colorectal cancer10.2
37autosomal dominant optic atrophy, hearing loss, and peripheral neuropathy10.2
38autosomal recessive optic atrophy, hearing loss, and peripheral neuropathy10.2
39chediak-higashi syndrome10.2
40hepatitis c10.2
41transthyretin amyloidosis10.2
42krabbe disease10.2
43hereditary spastic paraplegia10.2
44cerebrotendinous xanthomatosis10.2
45poems syndrome10.2
46diabetic retinopathy10.2
47mononeuritis10.2
48myopathy10.2
49myositis10.2
50myotonic dystrophy10.2

Graphical network of the top 20 diseases related to Peripheral Neuropathy:



Diseases related to peripheral neuropathy

Clinical Features for Peripheral Neuropathy

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Drugs & Therapeutics for Peripheral Neuropathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Peripheral Neuropathy

Drug clinical trials:

Search ClinicalTrials for Peripheral Neuropathy

Search NIH Clinical Center for Peripheral Neuropathy

Search CenterWatch for Peripheral Neuropathy

Genetic Tests for Peripheral Neuropathy

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Anatomical Context for Peripheral Neuropathy

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Peripheral Neuropathy:

32
Spinal cord, Brain, Testes, Breast, Skin, T cells, Endothelial, Colon, Lung, Heart, B cells, Liver, Eye, Pituitary, Amygdala, Bone, Monocytes, Kidney, Thyroid, Skeletal muscle, Lymph node, Bone marrow, Whole blood

FMA organs/tissues related to Peripheral Neuropathy:

14
Nerves of the peripheral nervous system

Animal Models for Peripheral Neuropathy or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Peripheral Neuropathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539111.0GJC3, SLC12A6, GJB1, GJE1, GJA10, GJA8
2MP:000301210.9GJD3, GJB6, GJB3, GJA10, GJA5, GJD2
3MP:000363110.8SLC12A6, GJC2, GJB1, GJA10, GJD3, GJD2

Publications for Peripheral Neuropathy

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Sources:
50PubMed
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Articles related to Peripheral Neuropathy:

(show top 50)    (show all 1026)
idTitleAuthorsYear
1
ER stress in diabetic peripheral neuropathy: A new therapeutic target. (24382087)
2014
2
Prevention and treatment of chemotherapy-induced peripheral neuropathy. (24352178)
2014
3
Endoplasmic reticulum stress contributes to prediabetic peripheral neuropathy. (23142188)
2013
4
Cost comparison of drug-drug and drug-condition interactions in patients with painful diabetic peripheral neuropathy treated with pregabalin versus duloxetine. (24296843)
2013
5
Peripheral neuropathy caused by cryoglobulinaemia with false-positive serological tests of syphilis. (23673128)
2013
6
Nutraceuticals and chemotherapy induced peripheral neuropathy (CIPN): a systematic review. (23647723)
2013
7
Assessing patient-reported peripheral neuropathy: the reliability and validity of the European Organization for Research and Treatment of Cancer QLQ-CIPN20 Questionnaire. (23543373)
2013
8
Evaluation of tubulin polymerization and chronic inhibition of proteasome as citotoxicity mechanisms in bortezomib-induced peripheral neuropathy. (24335344)
2013
9
Pregabalin in Patients With Inadequately Treated Painful Diabetic Peripheral Neuropathy: A Randomized Withdrawal Trial. (23887339)
2013
10
Efficacy of goshajinkigan for oxaliplatin-induced peripheral neuropathy in colorectal cancer patients. (24307899)
2013
11
Chemotherapy-induced peripheral neuropathy in cancer patients: a four-arm randomized trial on the effectiveness of electroacupuncture. (24066010)
2013
12
High association of IL-4 gene intron 3 VNTR polymorphism with diabetic peripheral neuropathy. (23771787)
2013
13
Pulse pressure and michigan neuropathy screening instrument are independently associated with asymptomatic peripheral arterial disease among type 2 diabetes community residents: A community-based screening program in Taiwan. (24385070)
2013
14
Asymmetric time-dependent activation of right central amygdala neurones in rats with peripheral neuropathy and pregabalin modulation. (22861166)
2012
15
Relation of sensory peripheral neuropathy in SjAPgren syndrome to anti-Ro/SSA. (22955477)
2012
16
The prevalence, patterns and predictors of diabetic peripheral neuropathy in a developing country. (22642973)
2012
17
Vasculitis syndromes: Peripheral neuropathy in AAV--when vasculitis hits a nerve. (22143390)
2012
18
Omega-3 fatty acids are protective against paclitaxel-induced peripheral neuropathy: a randomized double-blind placebo controlled trial. (22894640)
2012
19
Acquired peripheral neuropathy: a report on 20 children. (22697084)
2012
20
Protective effect of gliclazide on diabetic peripheral neuropathy through Drp-1 mediated-oxidative stress and apoptosis. (22732450)
2012
21
Lipodystrophy and adrenal insufficiency: potential mediators of peripheral neuropathy in HIV infection? (22244839)
2012
22
Peripheral neuropathy of the extremity after hyperbaric exposure. (22872997)
2012
23
Peripheral neuropathy after hip replacement failure: is vanadium the culprit? (22541583)
2012
24
Peripheral neuropathy as a first sign of microscopic polyangiitis. (21183256)
2011
25
The role of sulfoglucuronosyl glycosphingolipids in the pathogenesis of monoclonal IgM paraproteinemia and peripheral neuropathy. (21785257)
2011
26
Both Schwann cell and axonal defects cause motor peripheral neuropathy in Ebf2-/- mice. (21220016)
2011
27
Integrin beta-3 L33P: a new insight into the pathogenesis of chronic oxaliplatin-induced peripheral neuropathy? (20192979)
2010
28
Prospective study of peripheral neuropathy in Machado-Joseph disease. (19802879)
2009
29
Relationship between GSTP1 Ile(105)Val polymorphism and docetaxel-induced peripheral neuropathy: clinical evidence of a role of oxidative stress in taxane toxicity. (19223573)
2009
30
The slipping slipper sign: a marker of severe peripheral diabetic neuropathy and foot sepsis. (19528301)
2009
31
Endothelial and neural regulation of skin microvascular blood flow in patients with diabetic peripheral neuropathy: effect of treatment with the isoform-specific protein kinase C beta inhibitor, ruboxistaurin. (18280438)
2008
32
Linezolid-associated peripheral and optic neuropathy, lactic acidosis, and serotonin syndrome. (17655517)
2007
33
Acute intermittent porphyria with peripheral neuropathy complicated by small-fiber neuropathy. (17494514)
2007
34
Cerebellar ataxia, peripheral neuropathy, "gluten sensitivity" and anti-neuronal autoantibodies. (17175889)
2006
35
Peripheral neuropathy--a novel finding in dyskeratosis congenita. (15843075)
2005
36
A woman complicated with immune thrombocytopenic purpura, subclinical Graves disease and peripheral neuropathy 5 years after allogeneic bone marrow transplantation]. (16440775)
2005
37
Charcot-Marie-Tooth disease and related peripheral neuropathies: novel mutations in the peripheral myelin genes connexin 32 (Cx32), peripheral myelin protein 22 (PMP22), and peripheral myelin protein zero (MPZ). (11085599)
2000
38
Peripheral neuropathy without cryoglobulinemia in patients with hepatitis C virus infection. (11218620)
2000
39
Inherited peripheral neuropathy. (10716658)
1999
40
A 50-year-old male with diabetes mellitus, peripheral neuropathy, hypothyroidism, obesity, sleep disorder, pickwickian syndrome, and heart failure. (9844373)
1998
41
Fatal vascular leak syndrome with extensive hemorrhage, peripheral neuropathy and reactive erythrophagocytosis: an unusual complication of recombinant IL-3 therapy. (8624477)
1996
42
Charcot-Marie-Tooth type 1B neuropathy: a mutation at the single glycosylation site in the major peripheral myelin glycoprotein Po. (8844219)
1996
43
Peripheral neuropathy in mice transgenic for a human MDR3 P-glycoprotein mini-gene. (8815917)
1996
44
Organophosphorus inhibition and heat inactivation kinetics of particulate and soluble forms of peripheral nerve neuropathy target esterase. (8568835)
1995
45
Mutations in demyelinating peripheral neuropathies support molecular model of myelin P0-glycoprotein extracellular domain. (7528817)
1994
46
Genetic basis of inherited peripheral neuropathies. (7515304)
1994
47
Gene dosage as a mechanism for a common autosomal dominant peripheral neuropathy: Charcot-Marie-Tooth disease type 1A. (8115402)
1993
48
Sensory and motor peripheral neuropathy in olivopontocerebellar atrophy. (3014798)
1986
49
Osteosclerotic myeloma and peripheral neuropathy. (6296727)
1983
50
Tarsal tunnel syndrome and peripheral neuropathy in rheumatoid disease. (6303230)
1983

Genetic Variations for Peripheral Neuropathy

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Expression for genes affiliated with Peripheral Neuropathy

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Peripheral Neuropathy

Search GEO for disease gene expression data for Peripheral Neuropathy.

Pathways for genes affiliated with Peripheral Neuropathy

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Sources:
53Reactome, 37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 12EMD Millipore
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Compounds for genes affiliated with Peripheral Neuropathy

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Sources:
59Tocris Bioscience, 28IUPHAR, 44Novoseek, 11DrugBank, 24HMDB, 2BitterDB
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Compounds related to Peripheral Neuropathy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1gap 275911.8GJB1, GJD4, GJE1, GJB4, GJA10, GJA8
2carbenoxolone28 44 1113.8GJE1, GJB4, GJA10, GJA8, GJD3, GJA4
3octanol28 2412.7GJB1, GJD4, GJE1, GJB4, GJA10, GJA8
4ca2+2811.7GJE1, GJB4, GJA10, GJA8, GJD3, GJA4
5flufenamic acid44 28 2 1114.6GJB1, GJD4, GJE1, GJB4, GJA10, GJA8
6carbenoxolone disodium5911.6GJE1, GJB4, GJA10, GJA8, GJD3, GJA4
710panx5911.5GJE1, GJB4, GJA10, GJA8, GJD3, GJA4
8scrambled 10panx5911.3GJB1, GJD4, GJE1, GJB4, GJA10, GJA8

GO Terms for genes affiliated with Peripheral Neuropathy

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16Gene Ontology
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Cellular components related to Peripheral Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1connexon complexGO:00592211.6GJB1, GJD4, GJA9, GJC3, GJC2, GJA3
2integral to membraneGO:01602111.1GJD4, GJA9, GJC3, GJC2, GJA3, GJB6
3gap junctionGO:00592110.7GJB3, GJD2, GJA5, GJA4, GJB4
4myelin sheathGO:04320910.6GJC2, GJC3

Biological processes related to Peripheral Neuropathy according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cell communicationGO:00715411.2GJE1, GJD4, GJA9, GJB6, GJB3, GJB5
2cell-cell signalingGO:00726710.9GJC2, GJA3, GJA4, GJA8, GJB1
3gap junction assemblyGO:01626410.8GJB1, GJD3, GJA5
4transportGO:00681010.7GJB1, GJA8, GJA4, GJA3
5visual perceptionGO:00760110.7GJA8, GJD2, GJA3
6sensory perception of soundGO:00760510.6GJC3, GJB6, GJB3
7lens development in camera-type eyeGO:00208810.3GJE1, GJA8

Molecular functions related to Peripheral Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1gap junction channel activityGO:00524310.9GJB1, GJB4, GJA10, GJD2, GJB3, GJA3

Products for genes affiliated with Peripheral Neuropathy

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Sources for Peripheral Neuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet