MCID: PRP023
MIFTS: 44

Peripheral Neuropathy malady

Neuronal diseases category

Summaries for Peripheral Neuropathy

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NINDS:42 Peripheral neuropathy describes damage to the peripheral nervous system, which transmits information from the brain and spinal cord to every other part of the body.

MalaCards based summary: Peripheral Neuropathy is related to neuropathy and sensory peripheral neuropathy. An important gene associated with Peripheral Neuropathy is SLC12A6 (solute carrier family 12 (potassium/chloride transporter), member 6), and among its related pathways are Potassium transporters inward current and Cell adhesion Endothelial cell contacts by junctional mechanisms. The compounds scrambled 10panx and carbenoxolone disodium have been mentioned in the context of this disorder. Affiliated tissues include nerves of the peripheral nervous system, spinal cord and brain, and related mouse phenotypes are no phenotypic analysis and nervous system.

Disease Ontology:9 A neuropathy that is located in nerves of the peripheral nervous system.

Wikipedia:63 Peripheral neuropathy (PN) is damage to or disease affecting nerves, which may impair sensation,... more...

Aliases & Classifications for Peripheral Neuropathy

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Peripheral Neuropathy, Aliases & Descriptions:

Name: Peripheral Neuropathy 9 42 11 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


External Ids:

Disease Ontology9 DOID:0060053

Related Diseases for Peripheral Neuropathy

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Diseases related to Peripheral Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 438)
idRelated DiseaseScoreTop Affiliating Genes
1neuropathy32.5GJB1
2sensory peripheral neuropathy31.3SLC12A6, GJB1
3charcot-marie-tooth disease30.9GJB1, GJC3
4cataract30.2GJA3, GJA8
5myeloma10.6
6ataxia10.6
7multiple myeloma10.5
8blindness10.5
9cryoglobulinemia10.5
10postherpetic neuralgia10.5
11spasticity10.5
12neuronitis10.4
13churg-strauss syndrome10.4
14leukemia10.4
15motor peripheral neuropathy10.4
16autosomal dominant optic atrophy, hearing loss, and peripheral neuropathy10.4
17peripheral neuropathy, myopathy, hoarseness, and hearing loss10.4
18tooth disease10.4
19cervical hypertrichosis peripheral neuropathy10.4
20breast cancer10.4
21hepatitis10.4
22autonomic neuropathy10.4
23dfnb110.3GJB6
24colorectal cancer10.3
25cerebrotendinous xanthomatosis10.3
26metachromatic leukodystrophy10.3
27autonomic peripheral neuropathy10.3
28autosomal recessive optic atrophy, hearing loss, and peripheral neuropathy10.3
29spastic paraparesis10.3
30systemic lupus erythematosus10.3
31chediak-higashi syndrome10.3
32krabbe disease10.3
33obesity10.3
34cerebellar ataxia10.3
35osteosclerotic myeloma10.3
36amyloidosis10.3
37dementia10.3
38lupus erythematosus10.3
39paraplegia10.3
40porphyria10.3
41erythrokeratodermia variabilis et progressiva10.3GJB3, GJB4
42agenesis of the corpus callosum with peripheral neuropathy10.2
43refsum disease10.2
44polyglucosan body disease, adult form10.2
45mednik syndrome10.2
46charcot-marie-tooth disease, type 1a10.2
47hereditary spastic paraplegia10.2
48hepatitis c10.2
49cockayne syndrome10.2
50olivopontocerebellar atrophy10.2

Graphical network of the top 20 diseases related to Peripheral Neuropathy:



Diseases related to peripheral neuropathy

Symptoms for Peripheral Neuropathy

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Drugs & Therapeutics for Peripheral Neuropathy

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Drug clinical trials:

Search ClinicalTrials for Peripheral Neuropathy

Search NIH Clinical Center for Peripheral Neuropathy

Genetic Tests for Peripheral Neuropathy

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Anatomical Context for Peripheral Neuropathy

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MalaCards organs/tissues related to Peripheral Neuropathy:

31
Spinal cord, Brain, Testes, Breast, Skin, T cells, Endothelial, Colon, Heart, Lung, Bone marrow, Eye, Bone, Whole blood, Lymph node, Skeletal muscle, Kidney, Liver, Thyroid, Monocytes, B cells, Amygdala, Pituitary

FMA organs/tissues related to Peripheral Neuropathy:

14
Nerves of the peripheral nervous system

Animal Models for Peripheral Neuropathy or affiliated genes

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MGI Mouse Phenotypes related to Peripheral Neuropathy:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.4GJB3, GJD2, GJA5, GJB6
2MP:00036317.8GJC2, GJB6, GJB1, GJD2, GJC3, SLC12A6
3MP:00053917.5SLC12A6, GJC2, GJA8, GJE1, GJB1, GJA3

Publications for Peripheral Neuropathy

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Articles related to Peripheral Neuropathy:

(show top 50)    (show all 950)
idTitleAuthorsYear
1
Delayed recovery and increased severity of Paclitaxel-induced peripheral neuropathy in patients with diabetes. (25870378)
2015
2
The role of oxidative stress and inflammatory response in high-fat diet induced peripheral neuropathy. (24407112)
2014
3
Therapeutic Effects of Fenofibrate on Diabetic Peripheral Neuropathy by Improving Endothelial and Neural Survival in db/db Mice. (24392081)
2014
4
Comparison of two chemotherapy-induced peripheral neuropathy measurement approaches in children. (24072474)
2014
5
Pain, sleep disturbances, and functional limitations in people living with HIV/AIDS-associated distal sensory peripheral neuropathy. (25513029)
2014
6
Whole body vibration therapy for painful diabetic peripheral neuropathy: a pilot study. (24139013)
2013
7
Phase 1/2 open-label dose-escalation study of plasmid DNA expressing two isoforms of hepatocyte growth factor in patients with painful diabetic peripheral neuropathy. (23609019)
2013
8
Association of thymidylate synthase polymorphisms with acute pancreatitis and/or peripheral neuropathy in HIV-infected patients on stavudine-based therapy. (23468971)
2013
9
The neurology of Sjogren's syndrome and the rheumatology of peripheral neuropathy and myelitis. (24307005)
2013
10
Ruboxistaurin for the treatment of diabetic peripheral neuropathy: a systematic review of randomized clinical trials. (24199167)
2013
11
Divergent effects of T cell costimulation and inflammatory cytokine production on autoimmune peripheral neuropathy provoked by Aire deficiency. (23487421)
2013
12
Association of statin use with peripheral neuropathy in the U.S. population 40 years of age or older. (23121724)
2013
13
Median nerve ultrasound in diabetic peripheral neuropathy with and without carpal tunnel syndrome. (23401087)
2013
14
Evaluation of the clinical efficacy of multiple lower-extremity nerve decompression in diabetic peripheral neuropathy. (23713665)
2013
15
Infantile peripheral neuropathy, deafness, and proximal tubulopathy associated with a novel mutation of the RRM2B gene: case study. (24382854)
2013
16
The correlation between pain-related behaviour and spinal microgliosis in four distinct models of peripheral neuropathy. (22467279)
2012
17
The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CBa88 receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy. (22998838)
2012
18
Asymmetric time-dependent activation of right central amygdala neurones in rats with peripheral neuropathy and pregabalin modulation. (22861166)
2012
19
Subclinical peripheral neuropathy is a common finding in colorectal cancer patients prior to chemotherapy. (22496202)
2012
20
Total vascular risk as a strong correlate of severity of diabetic peripheral neuropathy in Nigerian Africans. (22774318)
2012
21
Relation of sensory peripheral neuropathy in SjAPgren syndrome to anti-Ro/SSA. (22955477)
2012
22
Diabetic peripheral neuropathy is highly associated with nontraumatic fractures in Korean patients with type 2 diabetes mellitus. (21906118)
2012
23
Mitotoxicity and bortezomib-induced chronic painful peripheral neuropathy. (22947198)
2012
24
Comparison of different screening tests for diagnosis of diabetic peripheral neuropathy in Primary Health Care setting. (23580893)
2012
25
The prevalence, patterns and predictors of diabetic peripheral neuropathy in a developing country. (22642973)
2012
26
Peripheral neuropathies: Molecular diagnosis of Charcot-Marie-Tooth disease. (21587243)
2011
27
Association of osteonecrosis and peripheral neuropathy in HIV-1-infected patients: possible roles of nerve growth factor and vascular endothelial growth factor. (22067199)
2011
28
Prevalence of peripheral neuropathy in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). (21510232)
2011
29
Hereditary peripheral neuropathies]. (19327944)
2009
30
Prospective study of peripheral neuropathy in Machado-Joseph disease. (19802879)
2009
31
Peripheral neuropathy in a child with Cree leukodystrophy. (17641267)
2007
32
Diagnostic value of autoantibodies to MAG by ELISA BA1hlmann in 117 immune-mediated peripheral neuropathies associated with monoclonal IgM to SGPG/SGLPG]. (16829480)
2006
33
Peripheral neuropathy in CADASIL. (15827866)
2005
34
Peripheral neuropathy in pediatric systemic lupus erythematosus. (12770683)
2003
35
Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled double-blind parallel group study. (11574441)
2001
36
Severe peripheral neuropathy, cardiac hypofunction, and syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in a patient with Churg-Strauss syndrome]. (10614173)
1999
37
Olivopontocerebellar atrophy and peripheral neuropathy--Wadia type. (10999111)
1999
38
Confocal microscopic localization of anti-myelin-associated glycoprotein autoantibodies in a patient with peripheral neuropathy initially lacking a detectable IgM gammopathy. (9600601)
1998
39
The pathogenesis of diffuse infiltrative lymphocytosis syndrome: an AIDS-related peripheral neuropathy. (9566362)
1998
40
Peripheral neuropathy in acrodermatitis chronica atrophicans - a late Borrelia manifestation. (9228267)
1997
41
Demyelinating peripheral neuropathy with Creutzfeldt-Jakob disease and mutation at codon 200 of the prion protein gene. (8780103)
1996
42
Autosomal dominant optic atrophy with asymptomatic peripheral neuropathy. (8708653)
1996
43
Neurotrophic factors in the treatment of peripheral neuropathy. (8866130)
1996
44
TTR exon scanning in peripheral neuropathies. (7633183)
1995
45
Human beta-mannosidase deficiency associated with peripheral neuropathy. (8285582)
1994
46
The clinical spectrum and pathogenesis of HIV encephalopathy, myelopathy, and peripheral neuropathy. (8081514)
1994
47
Peripheral and autonomic nerve function in 259 diabetic patients with peripheral neuropathy treated with ponalrestat (an aldose reductase inhibitor) or placebo for 18 months. United Kingdom/Scandinavian Ponalrestat Trial. (1611136)
1992
48
Clinical and neurophysiological studies of aldose reductase inhibitor ponalrestat in chronic symptomatic diabetic peripheral neuropathy. (1901808)
1991
49
Peripheral neuropathy in cerebrotendinous xanthomatosis. (2994606)
1985
50
Orthopaedic management of childhood neuromuscular disease. Part II: peripheral neuropathies, Friedreich's ataxia, and arthrogryposis multiplex congenita. (6282888)
1982

Variations for Peripheral Neuropathy

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Expression for genes affiliated with Peripheral Neuropathy

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Search GEO for disease gene expression data for Peripheral Neuropathy.

Pathways for genes affiliated with Peripheral Neuropathy

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Compounds for genes affiliated with Peripheral Neuropathy

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Compounds related to Peripheral Neuropathy according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1scrambled 10panx595.4GJB3, GJC2, GJC3, GJD2, GJB4, GJA3
2carbenoxolone disodium595.4GJC3, GJD2, GJB4, GJA3, GJB1, GJA5
3gap 27595.3GJB3, GJC2, GJC3, GJD2, GJB4, GJA3
4octanol28 246.3GJC3, GJD2, GJB4, GJA3, GJB1, GJA5
5ca2+285.2GJB3, GJC2, GJC3, GJD2, GJB4, GJA3
610panx595.2GJC3, GJD2, GJB4, GJA3, GJB1, GJA5
7flufenamic acid28 43 2 128.1GJC3, GJD2, GJB4, GJA3, GJB1, GJA5
8carbenoxolone43 28 126.9GJB3, GJC2, GJC3, GJD2, GJB4, GJA3

GO Terms for genes affiliated with Peripheral Neuropathy

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Cellular components related to Peripheral Neuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1myelin sheathGO:00432099.8GJC3, GJC2
2gap junctionGO:00059219.0GJA4, GJA5, GJB3
3integral component of membraneGO:00160216.7GJC2, GJB6, GJB1, GJA3, GJB4, GJD2
4connexon complexGO:00059225.8GJB3, GJC2, GJB6, GJA4, GJA8, GJA5

Biological processes related to Peripheral Neuropathy according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1gap junction assemblyGO:00162649.7GJA5, GJB1
2potassium ion transportGO:00068139.6SLC12A6, GJA5
3endothelium developmentGO:00031589.4GJA5, GJA4
4protein oligomerizationGO:00512599.3GJA5, GJB1
5visual perceptionGO:00076019.3GJD2, GJA3, GJA8
6sensory perception of soundGO:00076059.1GJB6, GJC3, GJB3
7transportGO:00068109.0GJA4, GJA3, GJB1, GJA8
8cell communicationGO:00071548.9GJB6, GJB4, GJC3, GJB3
9transmembrane transportGO:00550858.8GJA8, SLC12A6, GJB3, GJD2, GJA5
10cell-cell signalingGO:00072678.7GJC2, GJA3, GJA8, GJA4, GJB1

Molecular functions related to Peripheral Neuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1gap junction channel activityGO:00052438.7GJB3, GJD2, GJA3, GJB1, GJC2

Products for genes affiliated with Peripheral Neuropathy

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Sources for Peripheral Neuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet