MCID: PRP026
MIFTS: 33

Peripheral Retinal Degeneration malady

Eye diseases, Cardiovascular diseases categories

Summaries for Peripheral Retinal Degeneration

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32MalaCards
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MalaCards: Peripheral Retinal Degeneration, also known as peripheral degeneration of retina, is related to retinal degeneration and retinitis. An important gene associated with Peripheral Retinal Degeneration is PRPH2 (peripherin 2 (retinal degeneration, slow)), and among its related pathways is Lysosome. Affiliated tissues include retina, eye and kidney, and related mouse phenotypes are vision/eye and nervous system.

Aliases & Classifications for Peripheral Retinal Degeneration

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8Disease Ontology, 10DISEASES, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases, Cardiovascular diseases


Aliases & Descriptions:

peripheral retinal degeneration 8 10
peripheral degeneration of retina 8 60
peripheral retinal degeneration, unspecified 8
unspecified peripheral retinal degeneration 8
peripheral retinal degeneration nos 8
peripheral retinal degenerations 8


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Disease Ontology8 DOID:12161
ICD9CM27 362.6, 362.60
NCIt39 C34919
ICD1025 H35.4, I73.9

Related Diseases for Peripheral Retinal Degeneration

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Peripheral Retinal Degeneration:



Diseases related to peripheral retinal degeneration

Clinical Features for Peripheral Retinal Degeneration

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Drugs & Therapeutics for Peripheral Retinal Degeneration

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Peripheral Retinal Degeneration

Drug clinical trials:

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Search NIH Clinical Center for Peripheral Retinal Degeneration

Search CenterWatch for Peripheral Retinal Degeneration

Genetic Tests for Peripheral Retinal Degeneration

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Anatomical Context for Peripheral Retinal Degeneration

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32MalaCards
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MalaCards organs/tissues related to Peripheral Retinal Degeneration:

32
Retina, Eye, Kidney

Animal Models for Peripheral Retinal Degeneration or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Peripheral Retinal Degeneration:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053917.4RPGR, PRPH2, CLN3, CLN5, ROM1
2MP:00036317.3RPGR, PRPH, PRPH2, CLN3, CLN5, ROM1

Publications for Peripheral Retinal Degeneration

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50PubMed
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Articles related to Peripheral Retinal Degeneration:

(show all 12)
idTitleAuthorsYear
1
Survival and Migration of Pre-induced Adult Human Peripheral Blood Mononuclear Cells in Retinal Degeneration Slow (rds) Mice Three Months After Subretinal Transplantation. (24350910)
2014
2
Chronic kidney disease, early age-related macular degeneration, and peripheral retinal drusen. (22053834)
2011
3
Prevalence and characteristics of peripheral retinal degeneration in Chinese adults with high myopia: a cross-sectional prevalence survey. (15829850)
2005
4
A peripherin/retinal degeneration slow mutation (Pro-210-Arg) associated with macular and peripheral retinal degeneration. (7862413)
1995
5
Dominant macular subretinal neovascularization with peripheral retinal degeneration. (2446233)
1987
6
Peripheral microcystoid retinal degeneration and retinoschisis. (7119344)
1982
7
Animal model: peripheral retinal degeneration in rats. (525679)
1979
8
The classification and terminology of peripheral retinal degeneration. (1160882)
1975
9
Peripheral retinal degeneration in high myopia. (5546858)
1971
10
Relationship between ophthalmoscopic and histopathologic findings in peripheral retinal degeneration. (5604436)
1967
11
Peripheral retinal degeneration. (6054908)
1967
12
Familial association of central and peripheral retinal degeneration. (13890923)
1961

Genetic Variations for Peripheral Retinal Degeneration

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Expression for genes affiliated with Peripheral Retinal Degeneration

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Peripheral Retinal Degeneration

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Pathways for genes affiliated with Peripheral Retinal Degeneration

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29KEGG
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Pathways related to Peripheral Retinal Degeneration according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2CLN5, CLN3

Compounds for genes affiliated with Peripheral Retinal Degeneration

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GO Terms for genes affiliated with Peripheral Retinal Degeneration

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16Gene Ontology
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Cellular components related to Peripheral Retinal Degeneration according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1photoreceptor outer segment membraneGO:0426229.4ROM1, PRPH
2lysosomeGO:0057649.2CLN5, CLN3
3Golgi apparatusGO:0057948.3CLN5, CLN3, RPGR

Biological processes related to Peripheral Retinal Degeneration according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell deathGO:0082199.2CLN5, CLN3
2lysosomal lumen acidificationGO:0070429.1CLN3, CLN5
3protein catabolic processGO:0301638.9CLN5, CLN3
4visual perceptionGO:0076018.6ROM1, CLN5, PRPH2, RPGR

Products for genes affiliated with Peripheral Retinal Degeneration

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Peripheral Retinal Degeneration

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet