MCID: PRP026
MIFTS: 23

Peripheral Retinal Degeneration malady

Eye, Cardiovascular categories

Summaries for Peripheral Retinal Degeneration

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33MalaCards
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MalaCards: Peripheral Retinal Degeneration, also known as peripheral degeneration of retina, is related to partial central choroid dystrophy and myopia 6. An important gene associated with Peripheral Retinal Degeneration is PRPH2 (peripherin 2 (retinal degeneration, slow)), and among its related pathways is Lysosome. Related mouse phenotypes are vision/eye and nervous system.

Aliases & Classifications for Peripheral Retinal Degeneration

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 27ICD9CM, 57SNOMED-CT, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye, Cardiovascular


Aliases & Descriptions:

peripheral retinal degeneration 8 10
peripheral degeneration of retina 8 61
peripheral retinal degeneration, unspecified 8
unspecified peripheral retinal degeneration 8
peripheral retinal degeneration nos 8
peripheral retinal degenerations 8


External Ids:

Disease Ontology8 DOID:12161
ICD9CM27 362.6, 362.60
NCIt40 C34919
ICD1025 H35.4, I73.9

Related Diseases for Peripheral Retinal Degeneration

Sources:
17GeneCards, 18GeneDecks
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Graphical network of diseases related to Peripheral Retinal Degeneration:



Diseases related to peripheral retinal degeneration

Clinical Features for Peripheral Retinal Degeneration

Drugs & Therapeutics for Peripheral Retinal Degeneration

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Peripheral Retinal Degeneration

Drug clinical trials:

Search ClinicalTrials for Peripheral Retinal Degeneration

Search NIH Clinical Center for Peripheral Retinal Degeneration

Search CenterWatch for Peripheral Retinal Degeneration

Genetic Tests for Peripheral Retinal Degeneration

Anatomical Context for Peripheral Retinal Degeneration

Animal Models for Peripheral Retinal Degeneration or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Peripheral Retinal Degeneration:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053917.4RPGR, PRPH2, CLN3, CLN5, ROM1
2MP:00036317.3RPGR, PRPH, PRPH2, CLN3, CLN5, ROM1

Publications for Peripheral Retinal Degeneration

Sources:
51PubMed
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Articles related to Peripheral Retinal Degeneration:

(show all 12)
idTitleAuthorsYear
1
Survival and Migration of Pre-induced Adult Human Peripheral Blood Mononuclear Cells in Retinal Degeneration Slow (rds) Mice Three Months After Subretinal Transplantation. (24350910)
2014
2
Chronic kidney disease, early age-related macular degeneration, and peripheral retinal drusen. (22053834)
2011
3
Prevalence and characteristics of peripheral retinal degeneration in Chinese adults with high myopia: a cross-sectional prevalence survey. (15829850)
2005
4
A peripherin/retinal degeneration slow mutation (Pro-210-Arg) associated with macular and peripheral retinal degeneration. (7862413)
1995
5
Dominant macular subretinal neovascularization with peripheral retinal degeneration. (2446233)
1987
6
Peripheral microcystoid retinal degeneration and retinoschisis. (7119344)
1982
7
Animal model: peripheral retinal degeneration in rats. (525679)
1979
8
The classification and terminology of peripheral retinal degeneration. (1160882)
1975
9
Peripheral retinal degeneration in high myopia. (5546858)
1971
10
Relationship between ophthalmoscopic and histopathologic findings in peripheral retinal degeneration. (5604436)
1967
11
Peripheral retinal degeneration. (6054908)
1967
12
Familial association of central and peripheral retinal degeneration. (13890923)
1961

Genetic Variations for Peripheral Retinal Degeneration

Expression for genes affiliated with Peripheral Retinal Degeneration

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Peripheral Retinal Degeneration

Search GEO for disease gene expression data for Peripheral Retinal Degeneration.

Pathways for genes affiliated with Peripheral Retinal Degeneration

Sources:
30KEGG
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Pathways related to Peripheral Retinal Degeneration according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2CLN5, CLN3

Compounds for genes affiliated with Peripheral Retinal Degeneration

GO Terms for genes affiliated with Peripheral Retinal Degeneration

Sources:
16Gene Ontology
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Cellular components related to Peripheral Retinal Degeneration according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1photoreceptor outer segment membraneGO:0426229.4ROM1, PRPH
2lysosomeGO:0057649.2CLN5, CLN3
3Golgi apparatusGO:0057948.3CLN5, CLN3, RPGR

Biological processes related to Peripheral Retinal Degeneration according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell deathGO:0082199.2CLN5, CLN3
2lysosomal lumen acidificationGO:0070429.1CLN3, CLN5
3protein catabolic processGO:0301638.9CLN5, CLN3
4visual perceptionGO:0076018.6ROM1, CLN5, PRPH2, RPGR

Products for genes affiliated with Peripheral Retinal Degeneration

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Peripheral Retinal Degeneration

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet