MCID: PRP036
MIFTS: 42

Peripheral T-Cell Lymphoma malady

Rare diseases, Cancer diseases, Immune diseases categories

Aliases & Classifications for Peripheral T-Cell Lymphoma

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Aliases & Descriptions for Peripheral T-Cell Lymphoma:

Name: Peripheral T-Cell Lymphoma 30 42 61
 
Lymphoma T-Cell Peripheral 44


Classifications:



External Ids:

ICD1025 C84.4

Summaries for Peripheral T-Cell Lymphoma

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MalaCards based summary: Peripheral T-Cell Lymphoma, also known as lymphoma t-cell peripheral, is related to anaplastic large cell lymphoma and panniculitis. An important gene associated with Peripheral T-Cell Lymphoma is GZMB (granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)), and among its related pathways are Granzyme Pathway and IL12-mediated signaling events. The compounds larc and tarc have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone, and related mouse phenotypes are mortality/aging and immune system.

Related Diseases for Peripheral T-Cell Lymphoma

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Diseases related to Peripheral T-Cell Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1anaplastic large cell lymphoma31.0CXCR3, GZMB, CCL17
2panniculitis31.0TIA1
3myositis30.9GZMB
4hodgkin lymphoma30.8MS4A1, CCL17, TIA1, GZMB
5follicular lymphoma30.5BCL10, MS4A1
6chronic lymphocytic leukemia30.5BCL10, MS4A1, CXCR3
7cutaneous t cell lymphoma30.4CXCR3, CCL17, GZMB, TIA1
8b-cell lymphomas30.4BCL10, CXCR3, CCL17, MS4A1, TIA1, GZMB
9ulcerative colitis30.3CCL17, CXCR3, GZMB
10malt lymphoma30.3BCL10, CXCR3
11leukemia30.3TIA1, NME1, GZMB, BCL10, CXCR3
12lymphomatoid papulosis30.2CXCR3, TIA1, CCL17, GZMB
13mycosis fungoides30.2TIA1, GZMB, CCL17, CXCR3
14angioimmunoblastic t-cell lymphoma10.7
15diffuse large b-cell lymphoma10.7
16eosinophilia10.6
17adult t-cell leukemia10.5
18composite lymphoma10.5
19t-cell leukemia10.5
20hematopoietic stem cell transplantation10.5
21hepatitis10.5
22myelofibrosis10.5
23hypereosinophilic syndrome10.5
24primary cutaneous unspecified peripheral t-cell lymphoma10.5
25hemophagocytic lymphohistiocytosis10.4
26lethal midline granuloma10.4
27adult-onset still's disease10.4
28lymphopenia10.4
29enteropathy-associated t-cell lymphoma10.4
30paragonimiasis10.4CCL17
31acute liver failure10.3
32mantle cell lymphoma10.3
33marginal zone b-cell lymphoma10.3
34nasopharyngitis10.3
35fasciitis10.3
36histiocytosis10.3
37mediastinitis10.3
38thyroiditis10.3
39tuberculosis10.3
40eosinophilic fasciitis10.3
41polymyositis10.3
42primary cutaneous aggressive epidermotropic cd8+ t-cell lymphoma10.3
43alk-negative anaplastic large cell lymphoma10.3
44nodular lymphocyte predominant hodgkin lymphoma10.3
45keratoacanthoma10.3NME1, GZMB
46lichen planus10.3GZMB, CXCR3
47cervical intraepithelial neoplasia10.2GZMB, NME1
48sjogren's syndrome10.2GZMB, CXCR3
49retinoblastoma10.2
50nasopharyngeal carcinoma10.2

Graphical network of the top 20 diseases related to Peripheral T-Cell Lymphoma:



Diseases related to peripheral t-cell lymphoma

Symptoms for Peripheral T-Cell Lymphoma

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Drugs & Therapeutics for Peripheral T-Cell Lymphoma

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FDA approved drugs:

id Drug Name Active Ingredient(s)13 Pharmaceutical Company Approval Date
1
Beleodaq13 38 BELINOSTAT Spectrum Pharmaceuticals Approved July 2014
FDA Label: Beleodaq
Malady that Drug Treats: relapsed or refractory peripheral T-cell lymphoma
Indications and Usage:13 Beleodaq is a histone deacetylase inhibitor indicated for the treatment of; patients with relapsed or refractory peripheral T-cell lymphoma (PTCL). This; indication is approved under accelerated approval based on tumor response; rate and duration of response. An improvement in survival or disease-related; symptoms has not been established. Continued approval for this indication; may be contingent upon verification and description of clinical benefit in the; confirmatory trial. (1)
DrugBank Targets: no targets
Mechanism of Action:13 
Target: histone deacetylase (HDAC)
Action: inhibitor
FDA: Beleodaq is a histone deacetylase (HDAC) inhibitor. HDACs catalyze the removal of acetyl groups from the; lysine residues of histones and some non-histone proteins. In vitro, belinostat caused the accumulation of; acetylated histones and other proteins, inducing cell cycle arrest and/or apoptosis of some transformed cells.; Belinostat shows preferential cytotoxicity towards tumor cells compared to normal cells. Belinostat inhibited; the enzymatic activity of histone deacetylases at nanomolar concentrations (<250 nM).
2
Folotyn13 38 PRALATREXATE Allos Therapeutics Approved September 2009
FDA Label: Folotyn
Malady that Drug Treats: peripheral T-cell lymphoma
Indications and Usage:13 FOLOTYN is a folate analog metabolic inhibitor indicated for the treatment of; patients with relapsed or refractory peripheral T-cell lymphoma (PTCL). This; indication is based on overall response rate. Clinical benefit such as; improvement in progression-free survival or overall survival has not been; demonstrated. (1)
DrugBank Targets:11 1. Dihydrofolate reductase; 2. Thymidylate synthase
Mechanism of Action:13 
Target: dihydrofolate reductase
Action: inhibitor
FDA: Pralatrexate is a folate analog metabolic inhibitor that competitively inhibits dihydrofolate reductase. It is also a; competitive inhibitor for polyglutamylation by the enzyme folylpolyglutamyl synthetase. This inhibition results; in the depletion of thymidine and other biological molecules the synthesis of which depends on single carbon; transfer. ;

Drug clinical trials:

Search ClinicalTrials for Peripheral T-Cell Lymphoma

Search NIH Clinical Center for Peripheral T-Cell Lymphoma

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Peripheral T-Cell Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Peripheral T-Cell Lymphoma

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Anatomical Context for Peripheral T-Cell Lymphoma

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MalaCards organs/tissues related to Peripheral T-Cell Lymphoma:

31
T cells, B cells, Bone, Bone marrow, Skin, Liver, Breast, Lymph node, Skeletal muscle, Colon, Spleen, Thyroid, Placenta, Nk cells, Endothelial, Tongue

Animal Models for Peripheral T-Cell Lymphoma or affiliated genes

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MGI Mouse Phenotypes related to Peripheral T-Cell Lymphoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107688.0CXCR3, BCL10, NME1, GZMB, CD8A, TIA1
2MP:00053876.4TIA1, CXCR3, MS4A1, CCL17, ITK, BCL10
3MP:00053976.2CD8A, TIA1, CXCR3, MS4A1, CCL17, ITK

Publications for Peripheral T-Cell Lymphoma

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Articles related to Peripheral T-Cell Lymphoma:

(show top 50)    (show all 591)
idTitleAuthorsYear
1
The first case report of composite bone marrow involvement by simultaneously developed peripheral T-cell lymphoma, not otherwise specified, and diffuse large B-cell lymphoma. (25553299)
2015
2
Pulmonary involvement of peripheral T-cell lymphoma manifesting as crazy paving pattern. (25552801)
2015
3
Follicular variant of peripheral T cell lymphoma with mediastinal involvement in a child: a case report. (25604350)
2015
4
Changing the paradigms of treatment in peripheral T-cell lymphoma: from biology to clinical practice. (25320373)
2014
5
Fatal peripheral T-cell lymphoma following intramuscular tuberculosis of the forearm. (25507242)
2014
6
Clinical analysis and prognostic significance of lymphoma-associated hemophagocytosis in peripheral T cell lymphoma. (23238896)
2013
7
Treatment of peripheral T cell lymphoma with an intensive protocol ACEP (adriamycin, cyclophosphamide, etoposide and prednisolone) and ifosfamide showing an important response and overall survival rates. (23550277)
2013
8
Peripheral T-cell lymphoma: The role of hematopoietic stem cell transplantation. (24075060)
2013
9
The role of high dose chemotherapy and autologous stem-cell transplantation in peripheral T-cell lymphoma: a review of the literature and new perspectives. (22541889)
2013
10
Distinct morphologic, phenotypic, and clinical-course characteristics of indolent peripheral T-cell lymphoma. (23706909)
2013
11
Identification of multiple subclones in peripheral T-cell lymphoma, not otherwise specified with genomic aberrations. (23342278)
2012
12
Accurate detection of the tumor clone in peripheral T-cell lymphoma biopsies by flow cytometric analysis of TCR-VI^ repertoire. (22627740)
2012
13
A rare case of Lennert's type peripheral T-cell lymphoma with t(14;19)(q11.2;q13.3). (22122800)
2012
14
Stem cell transplantation for paediatric patients with non-anaplastic peripheral T-cell lymphoma in Japan. (22881201)
2012
15
Identification and characterization of peripheral T-cell lymphoma-associated SEREX antigens. (21887344)
2011
16
Elevated LDH and paranasal sinus involvement are risk factors for central nervous system involvement in patients with peripheral T-cell lymphoma. (21220520)
2011
17
An update on the management of peripheral T-cell lymphoma and emerging treatment options. (22287871)
2011
18
Peripheral T-cell lymphoma. (21493798)
2011
19
Expression of tumor-associated macrophages and vascular endothelial growth factor correlates with poor prognosis of peripheral T-cell lymphoma, not otherwise specified. (21077742)
2011
20
Cutaneous peripheral T-cell lymphoma of cytotoxic phenotype mimicking extranodal NK/T-cell lymphoma. (21252637)
2011
21
Linkage of expression of chemokine receptors (CXCR3 and CCR4) and cytotoxic molecules in peripheral T cell lymphoma, not otherwise specified and ALK-negative anaplastic large cell lymphoma. (20217288)
2010
22
Cutaneous anaplastic large cell lymphoma and peripheral T-cell lymphoma NOS show distinct chromosomal alterations and differential expression of chemokine receptors and apoptosis regulators. (19710685)
2010
23
L-asparaginase-induced complete response in a relapsed patient with Epstein-Barr virus and cytotoxic peripheral T-cell lymphoma not otherwise specified. (21088358)
2010
24
Clinical trials for human T-cell lymphotropic virus type I-associated peripheral T-cell lymphoma in Japan. (20359583)
2010
25
Phase II trial of zanolimumab (HuMax-CD4) in relapsed or refractory non-cutaneous peripheral T cell lymphoma. (20629661)
2010
26
Central nervous system prophylaxis in peripheral T-cell lymphoma. (20595522)
2010
27
The spectrum of peripheral T-cell lymphomas. (19509496)
2009
28
Primary peripheral T-cell lymphoma of the orbit. (19667355)
2009
29
The International Prognostic Index predicts outcome in aggressive adult T-cell leukemia/lymphoma: analysis of 126 patients from the International Peripheral T-Cell Lymphoma Project. (19150954)
2009
30
Peripheral T-cell lymphoma resembling Kimura's disease. (18377587)
2008
31
Peripheral T-cell lymphoma with erysipelaslike spread. (18306845)
2008
32
Overexpression of Syk tyrosine kinase in peripheral T-cell lymphomas. (18401419)
2008
33
Synchronous advanced scrotal verrucous carcinoma with peripheral T-cell lymphoma. (17270651)
2007
34
Novel t(5;9)(q33;q22) fuses ITK to SYK in unspecified peripheral T-cell lymphoma. (16341044)
2006
35
Expression and clinical significance of nm23-H1 and MUC-1 in peripheral T-cell lymphoma]. (17166378)
2006
36
Abdominal subcutaneous nodules with florid granulomatous reaction in a 53-year-old woman. Peripheral T-cell lymphoma, unspecified. (16329738)
2005
37
CD56-positive peripheral T-cell lymphoma primarily presenting with tonsillar swelling]. (15553048)
2004
38
Primary peripheral T-cell lymphoma in subcutaneous tissue: sonographic findings. (15293305)
2004
39
Non-cytotoxic gamma-delta peripheral T-cell lymphoma affecting the mandibular and parotidal lymph nodes and the skin. (12688326)
2003
40
Peripheral T-cell lymphoma arising in the liver. (12375645)
2002
41
Acrokeratosis paraneoplastica (Bazex's syndrome): unusual association with a peripheral T-cell lymphoma. (11859956)
2001
42
CD20-Positive peripheral T-cell lymphoma: report of a case after nodular sclerosis Hodgkin's disease and review of the literature. (11106083)
2000
43
Peripheral T-cell lymphoma with Toutonlike tumor giant cells associated with HIV infection: report of two cases. (10328082)
1999
44
Molecular evaluation of bone marrow involvement in peripheral T-cell lymphoma with a PCR-mediated RNase protection assay. (10643155)
1999
45
Peripheral T-cell lymphoma with Reed-Sternberg-like cells of B-cell phenotype and genotype associated with Epstein-Barr virus infection. (10524524)
1999
46
A case of neural cell adhesion molecule-positive peripheral T-cell lymphoma associated with human T-cell lymphotrophic virus type 1 showing an unusual involvement of the gastrointestinal tract during the course of the disease. (7959673)
1994
47
Peripheral T-cell lymphoma in childhood: a report of five cases in Taiwan. (8177142)
1994
48
Characteristic clinicopathologic features of Epstein-Barr virus-associated peripheral T-cell lymphoma. (8101471)
1993
49
Peripheral T cell lymphoma associated with multiple myeloma. (8314165)
1993
50
Heterogeneous Epstein-Barr virus infection patterns in peripheral T-cell lymphoma of angioimmunoblastic lymphadenopathy type. (1327284)
1992

Variations for Peripheral T-Cell Lymphoma

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Expression for genes affiliated with Peripheral T-Cell Lymphoma

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Search GEO for disease gene expression data for Peripheral T-Cell Lymphoma.

Pathways for genes affiliated with Peripheral T-Cell Lymphoma

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Pathways related to Peripheral T-Cell Lymphoma according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8GZMB, NME1
2
Show member pathways
Immune response IL 12 induced IFN gamma production59
9.7GZMB, CD8A
3
Show member pathways
Ras signaling in the CD4+ TCR pathway36
9.7CD8A, GZMB
49.7CD8A, MS4A1
5
Show member pathways
9.3BCL10, ITK
6
Show member pathways
9.3CCL17, CXCR3
7
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I59
9.1CD8A, GZMB, BCL10
8
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
8.9ITK, BCL10, CD8A
9
Show member pathways
TCR signaling in naive CD8+ T cells36
8.9CD8A, BCL10, ITK
10
Show member pathways
8.9CD8A, BCL10, ITK
11
Show member pathways
8.8ITK, CCL17, CXCR3
12
Show member pathways
8.8CXCR3, CCL17, ITK
138.6CD8A, GZMB, BCL10, ITK

Compounds for genes affiliated with Peripheral T-Cell Lymphoma

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Compounds related to Peripheral T-Cell Lymphoma according to GeneCards Suite gene sharing:

(show all 18)
idCompoundScoreTop Affiliating Genes
1larc449.5CCL17, CXCR3
2tarc449.4CXCR3, CCL17
3paraffin449.4MS4A1, NME1, TIA1, GZMB
4[alcl]449.4CCL17, TIA1, GZMB
5ccl344 2810.3CXCR3, CCL17
6tacrolimus44 50 1111.2CCL17, GZMB, CXCR3
7rantes449.2CCL17, GZMB, CXCR3
8ccl444 2810.2CCL17, CXCR3
9il 10449.1CD8A, CCL17, CXCR3
10allergens449.0CXCR3, CCL17
11cyclosporin a44 28 6010.9GZMB, CCL17, ITK
12dexamethasone44 50 28 1111.8CXCR3, CCL17, NME1, GZMB
13nitric oxide44 24 1110.8GZMB, CXCR3, CCL17, NME1
14lipid448.7GZMB, ITK, MS4A1, BCL10
15tyrosine448.6CD8A, ITK, CXCR3, NME1, GZMB
16adp44 28 2410.5ITK, CXCR3, NME1, CCL17
17serine448.2NME1, BCL10, ITK, CXCR3, TIA1, GZMB
18calcium44 50 24 1111.0GZMB, CCL17, CXCR3, MS4A1, NME1, ITK

GO Terms for genes affiliated with Peripheral T-Cell Lymphoma

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Cellular components related to Peripheral T-Cell Lymphoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1immunological synapseGO:00017729.6GZMB, BCL10
2T cell receptor complexGO:00421019.3CD8A, BCL10
3external side of plasma membraneGO:00098979.0CD8A, MS4A1, CXCR3

Biological processes related to Peripheral T-Cell Lymphoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1T cell activationGO:00421109.4CD8A, ITK
2adaptive immune responseGO:00022509.3BCL10, ITK
3T cell receptor signaling pathwayGO:00508529.3BCL10, ITK
4cellular defense responseGO:00069689.0BCL10, ITK

Molecular functions related to Peripheral T-Cell Lymphoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein kinase bindingGO:00199019.0CD8A, NME1, BCL10

Sources for Peripheral T-Cell Lymphoma

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet