MCID: PRP036
MIFTS: 48

Peripheral T-Cell Lymphoma malady

Rare diseases, Cancer diseases, Immune diseases categories

Summaries for Peripheral T-Cell Lymphoma

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34MalaCards
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MalaCards: Peripheral T-Cell Lymphoma, also known as lymphoma t-cell peripheral, is related to b-cell lymphomas and anaplastic large cell lymphoma. An important gene associated with Peripheral T-Cell Lymphoma is GZMB (granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)), and among its related pathways are Granzyme Pathway and IL12-mediated signaling events. The compounds larc and tarc have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone, and related mouse phenotypes are mortality/aging and immune system.

Aliases & Classifications for Peripheral T-Cell Lymphoma

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Sources:
44NIH Rare Diseases, 32LifeMap Discoveryā„¢, 63UMLS, 46Novoseek, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Immune diseases


Aliases & Descriptions:

peripheral t-cell lymphoma 44 32 63
lymphoma t-cell peripheral 46


External Ids:

ICD1026 C84.4

Related Diseases for Peripheral T-Cell Lymphoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Peripheral T-Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 124)
idRelated DiseaseScoreTop Affiliating Genes
1b-cell lymphomas31.0TIA1, CXCR3, MS4A1, CCL17, BCL10, GZMB
2anaplastic large cell lymphoma30.9CXCR3, CCL17, GZMB
3leukemia30.8TIA1, CXCR3, BCL10, NME1, GZMB
4hodgkin's lymphoma30.7TIA1, MS4A1, CCL17, GZMB
5chronic lymphocytic leukemia30.6BCL10, MS4A1, CXCR3
6follicular lymphoma30.5MS4A1, BCL10
7cutaneous t cell lymphoma30.5TIA1, CXCR3, CCL17, GZMB
8myositis30.4GZMB
9ulcerative colitis30.3CXCR3, CCL17, GZMB
10malt lymphoma30.3BCL10, CXCR3
11lymphomatoid papulosis30.3TIA1, CXCR3, CCL17, GZMB
12mycosis fungoides30.3GZMB, CCL17, CXCR3, TIA1
13b-cell chronic lymphocytic leukemia30.3CXCR3, MS4A1, BCL10
14angioimmunoblastic t-cell lymphoma10.8
15diffuse large b-cell lymphoma10.7
16eosinophilia10.6
17adult t-cell leukemia10.5
18t-cell leukemia10.5
19composite lymphoma10.5
20hepatitis10.5
21hypereosinophilic syndrome10.5
22hematopoietic stem cell transplantation10.5
23hemophagocytic lymphohistiocytosis10.4
24lethal midline granuloma10.4
25adult-onset still's disease10.4
26lymphopenia10.4
27myelofibrosis10.4
28enteropathy-associated t-cell lymphoma10.4
29primary cutaneous unspecified peripheral t-cell lymphoma10.4
30acute liver failure10.3
31nasopharyngitis10.3
32mantle cell lymphoma10.3
33fasciitis10.3
34histiocytosis10.3
35marginal zone b-cell lymphoma10.3
36thyroiditis10.3
37eosinophilic fasciitis10.3
38polymyositis10.3
39primary cutaneous aggressive epidermotropic cd8+ t-cell lymphoma10.3
40alk-negative anaplastic large cell lymphoma10.3
41nodular lymphocyte predominant hodgkin lymphoma10.3
42crohn's disease10.2
43autoimmune thyroiditis10.2
44evans' syndrome10.2
45gastrointestinal lymphoma10.2
46celiac disease10.2
47hepatitis b10.2
48infectious mononucleosis10.2
49pyoderma gangrenosum10.2
50hepatitis a10.2

Graphical network of the top 20 diseases related to Peripheral T-Cell Lymphoma:



Diseases related to peripheral t-cell lymphoma

Symptoms for Peripheral T-Cell Lymphoma

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Drugs & Therapeutics for Peripheral T-Cell Lymphoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Peripheral T-Cell Lymphoma

Drug clinical trials:

Search ClinicalTrials for Peripheral T-Cell Lymphoma

Search NIH Clinical Center for Peripheral T-Cell Lymphoma

Search CenterWatch for Peripheral T-Cell Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Peripheral T-Cell Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Peripheral T-Cell Lymphoma

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Anatomical Context for Peripheral T-Cell Lymphoma

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34MalaCards
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MalaCards organs/tissues related to Peripheral T-Cell Lymphoma:

34
T cells, B cells, Bone, Bone marrow, Liver, Skin, Breast, Lymph node, Colon, Skeletal muscle, Nk cells, Placenta, Thyroid, Spleen, Endothelial

Animal Models for Peripheral T-Cell Lymphoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Peripheral T-Cell Lymphoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107688.0CXCR3, BCL10, NME1, GZMB, CD8A, TIA1
2MP:00053876.4TIA1, CXCR3, MS4A1, CCL17, ITK, BCL10
3MP:00053976.2CD8A, TIA1, CXCR3, MS4A1, CCL17, ITK

Publications for Peripheral T-Cell Lymphoma

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53PubMed
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Articles related to Peripheral T-Cell Lymphoma:

(show top 50)    (show all 547)
idTitleAuthorsYear
1
Clinical analysis and prognostic significance of lymphoma-associated hemophagocytosis in peripheral T cell lymphoma. (23238896)
2013
2
Treatment of peripheral T cell lymphoma with an intensive protocol ACEP (adriamycin, cyclophosphamide, etoposide and prednisolone) and ifosfamide showing an important response and overall survival rates. (23550277)
2013
3
Peripheral T-cell lymphoma: The role of hematopoietic stem cell transplantation. (24075060)
2013
4
The role of high dose chemotherapy and autologous stem-cell transplantation in peripheral T-cell lymphoma: a review of the literature and new perspectives. (22541889)
2013
5
Distinct morphologic, phenotypic, and clinical-course characteristics of indolent peripheral T-cell lymphoma. (23706909)
2013
6
Identification of multiple subclones in peripheral T-cell lymphoma, not otherwise specified with genomic aberrations. (23342278)
2012
7
Accurate detection of the tumor clone in peripheral T-cell lymphoma biopsies by flow cytometric analysis of TCR-VI^ repertoire. (22627740)
2012
8
A rare case of Lennert's type peripheral T-cell lymphoma with t(14;19)(q11.2;q13.3). (22122800)
2012
9
Stem cell transplantation for paediatric patients with non-anaplastic peripheral T-cell lymphoma in Japan. (22881201)
2012
10
Identification and characterization of peripheral T-cell lymphoma-associated SEREX antigens. (21887344)
2011
11
Elevated LDH and paranasal sinus involvement are risk factors for central nervous system involvement in patients with peripheral T-cell lymphoma. (21220520)
2011
12
An update on the management of peripheral T-cell lymphoma and emerging treatment options. (22287871)
2011
13
Peripheral T-cell lymphoma. (21493798)
2011
14
Expression of tumor-associated macrophages and vascular endothelial growth factor correlates with poor prognosis of peripheral T-cell lymphoma, not otherwise specified. (21077742)
2011
15
Cutaneous peripheral T-cell lymphoma of cytotoxic phenotype mimicking extranodal NK/T-cell lymphoma. (21252637)
2011
16
Nodular lymphocyte-predominant hodgkin lymphoma with atypical T cells: a morphologic variant mimicking peripheral T-cell lymphoma. (21997687)
2011
17
Multicentre phase II study of the CyclOBEAP regimen for patients with peripheral T-cell lymphoma with analysis of biomarkers. (21492124)
2011
18
Linkage of expression of chemokine receptors (CXCR3 and CCR4) and cytotoxic molecules in peripheral T cell lymphoma, not otherwise specified and ALK-negative anaplastic large cell lymphoma. (20217288)
2010
19
Cutaneous anaplastic large cell lymphoma and peripheral T-cell lymphoma NOS show distinct chromosomal alterations and differential expression of chemokine receptors and apoptosis regulators. (19710685)
2010
20
L-asparaginase-induced complete response in a relapsed patient with Epstein-Barr virus and cytotoxic peripheral T-cell lymphoma not otherwise specified. (21088358)
2010
21
Clinical trials for human T-cell lymphotropic virus type I-associated peripheral T-cell lymphoma in Japan. (20359583)
2010
22
Phase II trial of zanolimumab (HuMax-CD4) in relapsed or refractory non-cutaneous peripheral T cell lymphoma. (20629661)
2010
23
Central nervous system prophylaxis in peripheral T-cell lymphoma. (20595522)
2010
24
The spectrum of peripheral T-cell lymphomas. (19509496)
2009
25
Primary peripheral T-cell lymphoma of the orbit. (19667355)
2009
26
The International Prognostic Index predicts outcome in aggressive adult T-cell leukemia/lymphoma: analysis of 126 patients from the International Peripheral T-Cell Lymphoma Project. (19150954)
2009
27
Peripheral T-cell lymphoma resembling Kimura's disease. (18377587)
2008
28
Peripheral T-cell lymphoma with erysipelaslike spread. (18306845)
2008
29
Overexpression of Syk tyrosine kinase in peripheral T-cell lymphomas. (18401419)
2008
30
Synchronous advanced scrotal verrucous carcinoma with peripheral T-cell lymphoma. (17270651)
2007
31
Novel t(5;9)(q33;q22) fuses ITK to SYK in unspecified peripheral T-cell lymphoma. (16341044)
2006
32
Expression and clinical significance of nm23-H1 and MUC-1 in peripheral T-cell lymphoma]. (17166378)
2006
33
Peripheral T-cell lymphoma in the neck: CT findings of lymph node involvement. (16687547)
2006
34
Peripheral T-cell lymphoma of the eyelid. (16897229)
2006
35
Abdominal subcutaneous nodules with florid granulomatous reaction in a 53-year-old woman. Peripheral T-cell lymphoma, unspecified. (16329738)
2005
36
CD56-positive peripheral T-cell lymphoma primarily presenting with tonsillar swelling]. (15553048)
2004
37
Primary peripheral T-cell lymphoma in subcutaneous tissue: sonographic findings. (15293305)
2004
38
Non-cytotoxic gamma-delta peripheral T-cell lymphoma affecting the mandibular and parotidal lymph nodes and the skin. (12688326)
2003
39
Peripheral T-cell lymphoma arising in the liver. (12375645)
2002
40
Acrokeratosis paraneoplastica (Bazex's syndrome): unusual association with a peripheral T-cell lymphoma. (11859956)
2001
41
CD20-Positive peripheral T-cell lymphoma: report of a case after nodular sclerosis Hodgkin's disease and review of the literature. (11106083)
2000
42
Peripheral T-cell lymphoma with Toutonlike tumor giant cells associated with HIV infection: report of two cases. (10328082)
1999
43
Molecular evaluation of bone marrow involvement in peripheral T-cell lymphoma with a PCR-mediated RNase protection assay. (10643155)
1999
44
Peripheral T-cell lymphoma with Reed-Sternberg-like cells of B-cell phenotype and genotype associated with Epstein-Barr virus infection. (10524524)
1999
45
The T-cell activation markers CD30 and OX40/CD134 are expressed in nonoverlapping subsets of peripheral T-cell lymphoma. (10233901)
1999
46
A case of neural cell adhesion molecule-positive peripheral T-cell lymphoma associated with human T-cell lymphotrophic virus type 1 showing an unusual involvement of the gastrointestinal tract during the course of the disease. (7959673)
1994
47
Peripheral T-cell lymphoma in childhood: a report of five cases in Taiwan. (8177142)
1994
48
Characteristic clinicopathologic features of Epstein-Barr virus-associated peripheral T-cell lymphoma. (8101471)
1993
49
Peripheral T cell lymphoma associated with multiple myeloma. (8314165)
1993
50
Heterogeneous Epstein-Barr virus infection patterns in peripheral T-cell lymphoma of angioimmunoblastic lymphadenopathy type. (1327284)
1992

Variations for Peripheral T-Cell Lymphoma

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Expression for genes affiliated with Peripheral T-Cell Lymphoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Peripheral T-Cell Lymphoma

Search GEO for disease gene expression data for Peripheral T-Cell Lymphoma.

Pathways for genes affiliated with Peripheral T-Cell Lymphoma

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51PathCards, 54QIAGEN, 39NCBI BioSystems Database, 61Thomson Reuters, 31KEGG, 56Reactome, 55R&D Systems, 5Cell Signaling Technology
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Pathways related to Peripheral T-Cell Lymphoma according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8GZMB, NME1
2
Show member pathways
Immune response IL 12 induced IFN gamma production61
9.7GZMB, CD8A
3
Show member pathways
Ras signaling in the CD4+ TCR pathway39
9.7CD8A, GZMB
49.7CD8A, MS4A1
5
Show member pathways
9.3BCL10, ITK
6
Show member pathways
9.3CCL17, CXCR3
7
Show member pathways
Proteasome Degradation39
Immune response Antigen presentation by MHC class I61
9.1CD8A, GZMB, BCL10
8
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
8.9ITK, BCL10, CD8A
9
Show member pathways
TCR signaling in naive CD8+ T cells39
8.9CD8A, BCL10, ITK
10
Show member pathways
8.9CD8A, BCL10, ITK
11
Show member pathways
8.8ITK, CCL17, CXCR3
12
Show member pathways
8.8CXCR3, CCL17, ITK
138.6CD8A, GZMB, BCL10, ITK

Compounds for genes affiliated with Peripheral T-Cell Lymphoma

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46Novoseek, 30IUPHAR, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 25HMDB
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Compounds related to Peripheral T-Cell Lymphoma according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1larc469.5CXCR3, CCL17
2tarc469.4CXCR3, CCL17
3paraffin469.4TIA1, MS4A1, NME1, GZMB
4[alcl]469.4GZMB, CCL17, TIA1
5ccl346 3010.3CCL17, CXCR3
6tacrolimus46 52 1211.2GZMB, CCL17, CXCR3
7rantes469.2CXCR3, CCL17, GZMB
8ccl446 3010.2CXCR3, CCL17
9il 10469.1CD8A, CCL17, CXCR3
10allergens469.0CCL17, CXCR3
11cyclosporin a46 30 6210.9GZMB, ITK, CCL17
12dexamethasone46 52 30 1211.8GZMB, NME1, CCL17, CXCR3
13nitric oxide46 25 1210.8GZMB, NME1, CCL17, CXCR3
14lipid468.7GZMB, BCL10, ITK, MS4A1
15tyrosine468.6CXCR3, ITK, NME1, GZMB, CD8A
16adp46 30 2510.5NME1, ITK, CCL17, CXCR3
17serine468.2TIA1, CXCR3, ITK, BCL10, NME1, GZMB
18calcium46 52 25 1211.0CXCR3, MS4A1, CCL17, ITK, NME1, GZMB

GO Terms for genes affiliated with Peripheral T-Cell Lymphoma

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17Gene Ontology
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Cellular components related to Peripheral T-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immunological synapseGO:0017729.6GZMB, BCL10
2T cell receptor complexGO:0421019.3CD8A, BCL10
3external side of plasma membraneGO:0098979.0CD8A, MS4A1, CXCR3

Biological processes related to Peripheral T-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1T cell activationGO:0421109.4CD8A, ITK
2adaptive immune responseGO:0022509.3BCL10, ITK
3T cell receptor signaling pathwayGO:0508529.3BCL10, ITK
4cellular defense responseGO:0069689.0BCL10, ITK

Molecular functions related to Peripheral T-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein kinase bindingGO:0199019.0CD8A, NME1, BCL10

Products for genes affiliated with Peripheral T-Cell Lymphoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Peripheral T-Cell Lymphoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet