MCID: PRP036
MIFTS: 38

Peripheral T-Cell Lymphoma malady

Cancer diseases, Immune diseases categories

Summaries for Peripheral T-Cell Lymphoma

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32MalaCards
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MalaCards: Peripheral T-Cell Lymphoma, also known as lymphoma t-cell peripheral, is related to cutaneous t cell lymphoma and anaplastic large cell lymphoma. An important gene associated with Peripheral T-Cell Lymphoma is GZMB (granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)), and among its related pathways are Immune response Fc epsilon RI pathway and B Cell Receptor Signaling Pathway. The compounds [alcl] and larc have been mentioned in the context of this disorder. Affiliated tissues include t cells and bone, and related mouse phenotypes are cellular and immune system.

Aliases & Classifications for Peripheral T-Cell Lymphoma

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Sources:
42NIH Rare Diseases, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Immune diseases


Aliases & Descriptions:

peripheral t-cell lymphoma 42 30 60
lymphoma t-cell peripheral 44


External Ids:

ICD1025 C84.4

Related Diseases for Peripheral T-Cell Lymphoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Peripheral T-Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 146)
idRelated DiseaseScoreTop Affiliating Genes
1cutaneous t cell lymphoma31.3TIA1, CCR4, CCL17, GZMB, TNFRSF8, CXCR3
2anaplastic large cell lymphoma31.0CCR4, CCL17, GZMB, TNFRSF8, CXCR3, BCL6
3leukemia30.9TIA1, CCL20, GZMB, CD19, CXCR3, NME1
4hodgkin's lymphoma30.8TIA1, CCR4, BCL3, BCL6, MS4A1, TCL1A
5central nervous system lymphoma30.7BCL6
6hepatitis30.7GZMB
7chronic lymphocytic leukemia30.6CCL19, CD19, CXCR3, TCL1A, MS4A1, BCL6
8gastric lymphoma30.6BCL10, BCL6
9hepatitis b30.2TNFRSF8, GZMB
10multiple myeloma30.2CD19
11angioimmunoblastic t-cell lymphoma30.2CXCL13, BCL6
12arthritis30.2CXCR3, GZMB, CCL20
13mycosis fungoides30.2CCR4, TIA1, CCL17, GZMB, CXCR3, TNFRSF8
14myeloma30.2TNFRSF8, MYEOV, CD19, TCL1A, BCL6
15myositis30.2GZMB
16tuberculosis30.2CCR4, GZMB, TNFRSF8, CXCR3
17ulcerative colitis30.2CCL20, CCL17, GZMB, CXCR3
18inflammatory bowel disease30.2CCL20
19diffuse large b-cell lymphoma10.7
20composite lymphoma10.7
21adult lymphoma10.7
22bone lymphoma10.6
23t-cell leukemia10.6
24gastrointestinal lymphoma10.5
25liver lymphoma10.5
26eosinophilia10.5
27adult t-cell leukemia10.5
28breast lymphoma10.5
29mantle cell lymphoma10.5
30myelofibrosis10.5
31colon lymphoma10.4
32hemophagocytic lymphohistiocytosis10.4
33lethal midline granuloma10.4
34orbit lymphoma10.4
35adult-onset still's disease10.4
36hepatitis a10.4
37lymphopenia10.4
38primary cutaneous unspecified peripheral t-cell lymphoma10.4
39acute liver failure10.3
40thyroid lymphoma10.3
41testicular lymphoma10.3
42nasopharyngitis10.3
43pediatric lymphoma10.3
44fasciitis10.3
45histiocytosis10.3
46marginal zone b-cell lymphoma10.3
47thyroiditis10.3
48enteropathy-associated t-cell lymphoma10.3
49stroke, ischemic10.2
50crohn's disease10.2

Graphical network of the top 20 diseases related to Peripheral T-Cell Lymphoma:



Diseases related to peripheral t-cell lymphoma

Clinical Features for Peripheral T-Cell Lymphoma

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Drugs & Therapeutics for Peripheral T-Cell Lymphoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Peripheral T-Cell Lymphoma

Drug clinical trials:

Search ClinicalTrials for Peripheral T-Cell Lymphoma

Search NIH Clinical Center for Peripheral T-Cell Lymphoma

Search CenterWatch for Peripheral T-Cell Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Peripheral T-Cell Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Peripheral T-Cell Lymphoma

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Anatomical Context for Peripheral T-Cell Lymphoma

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32MalaCards
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MalaCards organs/tissues related to Peripheral T-Cell Lymphoma:

32
T cells, Bone

Animal Models for Peripheral T-Cell Lymphoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Peripheral T-Cell Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538410.4ITK, CD19, CXCR3, CXCL13, TCF7, MS4A1
2MP:000538710.2BCL10, TIA1, CCR4, CCL19, CCL17, GZMB
3MP:000539710.0ITK, TNFRSF8, GZMB, CCL19, CCR4, TIA1

Publications for Peripheral T-Cell Lymphoma

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Genetic Variations for Peripheral T-Cell Lymphoma

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Expression for genes affiliated with Peripheral T-Cell Lymphoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Peripheral T-Cell Lymphoma

Search GEO for disease gene expression data for Peripheral T-Cell Lymphoma.

Pathways for genes affiliated with Peripheral T-Cell Lymphoma

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Sources:
12EMD Millipore, 37NCBI BioSystems Database, 29KEGG, 4Cell Signaling Technology, 53Reactome, 51QIAGEN
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Pathways related to Peripheral T-Cell Lymphoma according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4BCL6, CD19, ITK, GZMB
210.4ITK, CD19, BCL6, BCL10
310.4GZMB, ITK, CD19, BCL6, BCL10
4
Hide members
10.4CCR4, CCL20, CCL19, CCL17, CXCR3, CXCL13
510.4CXCL13, CXCR3, CCL17, CCL19, CCL20, CCR4
6
Hide members
10.4CCR4, CCL20, CCL19, CCL17, GZMB, CD19
7
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10.4CCR4, CCL20, CCL19, CCL17, ITK, CXCR3
8
Hide members
10.4CCR4, CCL20, CCL19, CCL17, ITK, CXCR3
9
Hide members
10.4CCR4, CCL20, CCL19, CCL17, TNFRSF8, CXCR3
10
Hide members
10.4CCR4, CCL20, CCL19, CCL17, TNFRSF8, CXCR3
11
Hide members
10.4CCR4, TCF7, CXCL13, CXCR3, TNFRSF8, CCL17
12
Hide members
10.3CXCR3, ITK, TNFRSF8, CCL17, CCL19, CCL20

Compounds for genes affiliated with Peripheral T-Cell Lymphoma

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Sources:
44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Peripheral T-Cell Lymphoma according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1[alcl]4410.7BCL3, TNFRSF8, GZMB, CCL17, CCR4, TIA1
2larc4410.7CCR4, CCL20, CCL19, CCL17, CXCR3
3tarc4410.7CCR4, CCL20, CCL19, CCL17, CXCR3
4rantes4410.7CXCR3, GZMB, CCL20
5ccl344 2811.7CCR4, CCL20, CCL19, CCL17, CXCR3
6paraffin4410.7TIA1, CCR4, GZMB, TNFRSF8, NME1, MS4A1
7ccl444 2811.6CCR4, CCL20, CCL17, CXCR3
8teck4410.6CXCL13, CCL19, CCR4
9serine4410.6GZMB, ITK, CXCR3, NME1, TCL1A, BCL10
10calcium44 49 11 2413.6CCR4, CCL20, CCL19, CCL17, GZMB, TNFRSF8
11tyrosine4410.5CCR4, GZMB, TNFRSF8, ITK, CD19, CXCR3
12lipid4410.5CCR4, GZMB, TNFRSF8, ITK, CD19, MS4A1
13allergens4410.5CXCR3, CCL17, CCL20
14peg-104410.4CXCL13, CCL19
15dexamethasone44 49 28 1113.4NME1, CXCR3, GZMB, CCL17, CCL20
16ricin4410.3TNFRSF8, CD19
17prednisolone44 28 1112.2GZMB, CCR4, TIA1

GO Terms for genes affiliated with Peripheral T-Cell Lymphoma

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16Gene Ontology
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Cellular components related to Peripheral T-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.4MS4A1, CXCR3, CD19, CCR4

Biological processes related to Peripheral T-Cell Lymphoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1germinal center formationGO:00246710.6CXCL13, BCL6, BCL3
2immune responseGO:00695510.5MS4A1, TCF7, CXCL13, CCL17, CCL19, CCL20
3chemotaxisGO:00693510.5CXCR3, CCL17, CCL20, CCR4
4inflammatory responseGO:00695410.5CCR4, CCL20, CCL19, CCL17, CXCR3
5adaptive immune responseGO:00225010.5BCL10, ITK
6cellular defense responseGO:00696810.5BCL10, CD19, ITK
7elevation of cytosolic calcium ion concentrationGO:00720410.3CCR4, CXCR3, CXCL13
8defense response to bacteriumGO:04274210.1BCL3, CXCL13, CCL20

Molecular functions related to Peripheral T-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:00495010.5CXCR3, CCR4
2chemokine activityGO:00800910.3CXCL13, CCL17, CCL19, CCL20
3CCR10 chemokine receptor bindingGO:03173510.1CXCL13, CCL19

Products for genes affiliated with Peripheral T-Cell Lymphoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Peripheral T-Cell Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet