MCID: PRP036
MIFTS: 47

Peripheral T-Cell Lymphoma malady

Cancer, Immune categories

Summaries for Peripheral T-Cell Lymphoma

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33MalaCards
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MalaCards: Peripheral T-Cell Lymphoma, also known as lymphoma t-cell peripheral, is related to lymphoma, diffuse large cell and follicular lymphoma. An important gene associated with Peripheral T-Cell Lymphoma is GZMB (granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)), and among its related pathways are Immune response Fc epsilon RI pathway and B Cell Receptor Signaling Pathway. The compounds [alcl] and larc have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and spleen, and related mouse phenotypes are cellular and immune system.

Aliases & Classifications for Peripheral T-Cell Lymphoma

Sources:
43NIH Rare Diseases, 31LifeMap Discovery™, 61UMLS, 45Novoseek, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Immune


Aliases & Descriptions:

peripheral t-cell lymphoma 43 31 61
lymphoma t-cell peripheral 45


External Ids:

ICD1025 C84.4

Related Diseases for Peripheral T-Cell Lymphoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Peripheral T-Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 132)
idRelated DiseaseScoreTop Affiliating Genes
1lymphoma, diffuse large cell31.1BCL6, TNFRSF8, MS4A1
2follicular lymphoma31.0MS4A1, BCL6, BCL3, TCL1A, BCL10
3b-cell lymphomas31.0TIA1, TNFRSF8, CD19, CXCR3, CXCL13, TCL1A
4anaplastic large cell lymphoma31.0GZMB, CXCR3, BCL6, TNFRSF8, BCL3, CCR4
5angioimmunoblastic t-cell lymphoma30.9BCL6, CXCL13
6central nervous system lymphoma30.8BCL6
7gastric lymphoma30.6BCL6, BCL10
8hepatitis c30.5CXCR3, CCL20
9central nervous system lymphoma, primary30.5BCL6, CXCL13
10lymphomatoid papulosis30.2TNFRSF8, TIA1, CCR4, CCL17, CXCR3, GZMB
11arthritis30.2CCL20, GZMB, CXCR3
12mycosis fungoides30.2TNFRSF8, CXCR3, GZMB, CCL17, CCR4, TIA1
13tuberculosis30.2GZMB, CCR4, CXCR3, TNFRSF8
14ulcerative colitis30.2CCL17, CXCR3, CCL20, GZMB
15composite lymphoma10.7
16adult lymphoma10.7
17bone lymphoma10.6
18gastrointestinal lymphoma10.6
19liver lymphoma10.6
20breast lymphoma10.5
21mantle cell lymphoma10.5
22hypereosinophilic syndrome10.5
23colon lymphoma10.4
24hemophagocytic lymphohistiocytosis10.4
25lethal midline granuloma10.4
26orbit lymphoma10.4
27adult-onset still's disease10.4
28diffuse large b-cell lymphoma10.4
29hematopoietic stem cell transplantation10.4
30acute liver failure10.3
31thyroid lymphoma10.3
32testicular lymphoma10.3
33pediatric lymphoma10.3
34n syndrome10.3
35eosinophilic fasciitis10.3
36polymyositis10.3
37nodular lymphocyte predominant hodgkin lymphoma10.3
38primary cutaneous unspecified peripheral t-cell lymphoma10.3
39stroke, ischemic10.2
40kimura disease10.2
41paranasal sinus lymphoma10.2
42evans' syndrome10.2
43autoimmune thyroiditis10.2
44hodgkin's lymphoma, nodular sclerosis10.2
45job's syndrome10.2
46erysipelas10.2
47osteopetrosis10.2
48cellulitis10.2
49common variable immunodeficiency10.2
50adult t-cell leukemia10.2

Graphical network of the top 20 diseases related to Peripheral T-Cell Lymphoma:



Diseases related to peripheral t-cell lymphoma

Clinical Features for Peripheral T-Cell Lymphoma

Drugs & Therapeutics for Peripheral T-Cell Lymphoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Peripheral T-Cell Lymphoma

Drug clinical trials:

Search ClinicalTrials for Peripheral T-Cell Lymphoma

Search NIH Clinical Center for Peripheral T-Cell Lymphoma

Search CenterWatch for Peripheral T-Cell Lymphoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Peripheral T-Cell Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Peripheral T-Cell Lymphoma

Anatomical Context for Peripheral T-Cell Lymphoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Peripheral T-Cell Lymphoma:

33
Bone marrow, Lymph node, Spleen, Skeletal muscle, Small intestine, Liver, Thyroid, Adrenal gland, Breast, Skin, Testis, Tonsil, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial

Animal Models for Peripheral T-Cell Lymphoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Peripheral T-Cell Lymphoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538410.4BCL3, BCL6, MS4A1, TCF7, CXCL13, CXCR3
2MP:000538710.2TNFRSF8, TCF7, CXCL13, CXCR3, CD19, ITK
3MP:000539710.0CCR4, CCL19, GZMB, TNFRSF8, ITK, MS4A1

Publications for Peripheral T-Cell Lymphoma

Sources:
51PubMed
See all sources

Articles related to Peripheral T-Cell Lymphoma:

(show top 50)    (show all 274)
idTitleAuthorsYear
1
EBV-driven relapse of peripheral T-cell lymphoma, masquerading as a post transplant lymphoproliferative disorder following allo-SCT. (23933761)
2014
2
MicroRNA187 overexpression is related to tumor progression and determines sensitivity to bortezomib in peripheral T-cell lymphoma. (24104394)
2013
3
Hypereosinophilic syndrome - lymphocytic variant transforming into peripheral T-cell lymphoma with severe oral manifestations. (23669204)
2013
4
Successful treatment of small cell variant anaplastic large cell lymphoma with allogeneic peripheral blood stem cell transplantation, and review of the literature. (23264126)
2013
5
Peripheral T-cell lymphoma: what's the role for transplant? (24282986)
2013
6
Peripheral T-cell lymphoma presenting as testicular mass; a diagnostic challenge. (23497214)
2013
7
Primary peripheral T-cell lymphoma, not otherwise specified of the thyroid with autoimmune thyroiditis. (23432459)
2013
8
Comparison of outcomes between autologous and allogeneic hematopoietic stem cell transplantation for peripheral T-cell lymphomas with central review of pathology. (23183430)
2013
9
A retrospective analysis of peripheral T-cell lymphoma treated with the intention to transplant in the first remission. (24035712)
2013
10
A multicenter phase II trial to determine the safety and efficacy of combination therapy with denileukin diftitox and cyclophosphamide, doxorubicin, vincristine and prednisone in untreated peripheral T-cell lymphoma: the CONCEPT study. (23278639)
2013
11
Peripheral T-cell lymphoma: time for a T-cell-centric standard of care. (24282985)
2013
12
Results from a pivotal, open-label, phase II study of romidepsin in relapsed or refractory peripheral T-cell lymphoma after prior systemic therapy. (22271479)
2012
13
Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters. (22760778)
2012
14
Primary composite lymphoma of the larynx, composed of diffuse large B-cell lymphoma and peripheral T-cell lymphoma, not otherwise specified, presenting as left subglottic tracheal fistula, esophageal diverticulum, and neck abscess. (22371913)
2012
15
Peripheral T-cell lymphoma: frequency and distribution in a tertiary referral center in South India. (23455774)
2012
16
Cutaneous manifestations of unspecified peripheral T-cell lymphoma may be indicative of disease activity and predict response to therapy. (22869871)
2012
17
Expression of tumor-associated macrophages and vascular endothelial growth factor correlates with poor prognosis of peripheral T-cell lymphoma, not otherwise specified. (21077742)
2011
18
A large single-center experience with allogeneic stem-cell transplantation for peripheral T-cell non-Hodgkin lymphoma and advanced mycosis fungoides/Sezary syndrome. (21252059)
2011
19
Treatment with hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone combined with cytarabine and methotrexate results in poor mobilization of peripheral blood stem cells in patients with mantle cell lymphoma. (21314484)
2011
20
Laboratory correlates for a phase II trial of romidepsin in cutaneous and peripheral T-cell lymphoma. (19874311)
2010
21
THP-COP regimen for the treatment of peripheral T-cell lymphoma and adult T-cell leukemia/lymphoma: a multicenter phase II study. (20059527)
2010
22
Successful treatment with autologous peripheral blood stem cell transplantation for acquired immunodeficiency syndrome (AIDS)-related malignant lymphoma. (20009441)
2009
23
Treatment with plerixafor in non-Hodgkin's lymphoma and multiple myeloma patients to increase the number of peripheral blood stem cells when given a mobilizing regimen of G-CSF: implications for the heavily pretreated patient. (19167685)
2009
24
Peripheral T cell lymphoma with a high titer of proteinase-3-antineutrophil cytoplasmic antibodies that resembled Wegener's granulomatosis. (19952489)
2009
25
Primary cutaneous CD30+ anaplastic large-cell lymphoma with generalized skin involvement and involvement of one peripheral lymph node, successfully treated with low-dose oral etoposide. (19438576)
2009
26
Peripheral T-cell lymphoma, NOS arising in Warthin tumor: report of a case]. (19031731)
2008
27
Autologous hematopoietic stem cell transplantation in peripheral T-cell lymphoma using a uniform high-dose regimen. (17530000)
2007
28
Prognostic significance of circulating tumor cells in bone marrow or peripheral blood as detected by qualitative and quantitative PCR in pediatric NPM-ALK-positive anaplastic large-cell lymphoma. (17392503)
2007
29
Gene expression analysis of peripheral T cell lymphoma, unspecified, reveals distinct profiles and new potential therapeutic targets. (17304354)
2007
30
Incidence of Clostridium difficile-associated diarrhea before and after autologous peripheral blood stem cell transplantation for lymphoma and multiple myeloma. (16435018)
2006
31
Peripheral T-cell lymphoma with extensive dendritic cell network mimicking follicular dendritic cell tumor: a case report with pathologic, immunophenotypic, and molecular findings. (16891198)
2006
32
Coexistence of neocentromeric marker 3q and trisomy 3 in two different tissues in a 3-year-old boy with peripheral T-cell lymphoma: support for a gene dosage effect hypothesis. (17011987)
2006
33
Treatment of a patient with a nodal peripheral T-cell lymphoma (angioimmunoblastic T-Cell lymphoma) with a human monoclonal antibody against the CD4 antigen (HuMax-CD4). (15965283)
2005
34
A case of peripheral T-cell lymphoma unspecified involving subcutaneous tissue. (16019520)
2005
35
Epstein-Barr virus-associated peripheral T-cell lymphoma with gastrointestinal tract involvement. (14649966)
2003
36
CT findings in peripheral T-cell lymphoma involving the gastrointestinal tract. (12601189)
2003
37
BCL-2 family proteins in peripheral T-cell lymphomas: correlation with tumour apoptosis and proliferation. (12754745)
2003
38
Autologous stem cell transplant for relapsed and refractory peripheral T-cell lymphoma: variable outcome according to pathological subtype. (12648067)
2003
39
Cyclophosphamide, etoposide and G-CSF to mobilize peripheral blood stem cells for autologous stem cell transplantation in patients with lymphoma. (12209348)
2002
40
Mobilization of peripheral blood stem cells by granulocyte-colony stimulating factors: comparison of a standard dose of glycosylated and mutated granulocyte-colony stimulating factor in non-Hodgkin's lymphoma patients following CHOP therapy. (10761530)
2000
41
Peripheral T-cell lymphoma following rituximab therapy for B-cell lymphoma. (10215354)
1999
42
Crescentic glomerulonephritis developing 3 months after autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma. (9818704)
1998
43
Amplification of the TCL1 flanking region at 14q32.1 with no TCL1 gene transcription in a patient with peripheral T cell lymphoma. (9639427)
1998
44
G-CSF after peripheral blood stem cell transplantation in lymphoma patients significantly accelerated neutrophil recovery and shortened time in hospital: results of a randomized BNLI trial. (9432046)
1997
45
Bone marrow versus peripheral blood progenitor cells CD34 selection in patients with non-Hodgkin's lymphomas: different levels of tumor cell reduction. Implications for autografting. (9326252)
1997
46
Increase of mobilized CD34-positive peripheral blood progenitor cells in patients with Hodgkin's disease, non-Hodgkin's lymphoma, and cancer of the testis. (8733686)
1996
47
Granulocyte colony-stimulating factor following peripheral-blood progenitor-cell transplant in non-Hodgkin's lymphoma. (7535843)
1995
48
Patterns of cytokine gene expression in peripheral T-cell lymphoma of angioimmunoblastic lymphadenopathy type. (7742548)
1995
49
A case of neural cell adhesion molecule-positive peripheral T-cell lymphoma associated with human T-cell lymphotrophic virus type 1 showing an unusual involvement of the gastrointestinal tract during the course of the disease. (7959673)
1994
50
Peripheral T-cell lymphoma of AILD (angioimmunoblastic lymphadenopathy with dysproteinemia) type involving gastrointestinal tract. A morphologic, phenotypic and genotypic study. (1314007)
1992

Genetic Variations for Peripheral T-Cell Lymphoma

Expression for genes affiliated with Peripheral T-Cell Lymphoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Peripheral T-Cell Lymphoma

Search GEO for disease gene expression data for Peripheral T-Cell Lymphoma.

Pathways for genes affiliated with Peripheral T-Cell Lymphoma

Sources:
12EMD Millipore, 38NCBI BioSystems Database, 30KEGG, 4Cell Signaling Technology, 54Reactome, 52QIAGEN
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Pathways related to Peripheral T-Cell Lymphoma according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4BCL6, CD19, ITK, GZMB
210.4ITK, CD19, BCL6, BCL10
310.4GZMB, ITK, CD19, BCL6, BCL10
4
Hide members
10.4CCR4, CCL20, CCL19, CCL17, CXCR3, CXCL13
510.4CXCL13, CXCR3, CCL17, CCL19, CCL20, CCR4
6
Hide members
10.4CCR4, CCL20, CCL19, CCL17, GZMB, CD19
7
Hide members
10.4CCR4, CCL20, CCL19, CCL17, ITK, CXCR3
8
Hide members
10.4CCR4, CCL20, CCL19, CCL17, ITK, CXCR3
9
Hide members
10.4CCR4, CCL20, CCL19, CCL17, TNFRSF8, CXCR3
10
Hide members
10.4CCR4, CCL20, CCL19, CCL17, TNFRSF8, CXCR3
11
Hide members
10.4CCR4, TCF7, CXCL13, CXCR3, TNFRSF8, CCL17
12
Hide members
10.3CXCR3, ITK, TNFRSF8, CCL17, CCL19, CCL20

Compounds for genes affiliated with Peripheral T-Cell Lymphoma

Sources:
45Novoseek, 29IUPHAR, 50PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Peripheral T-Cell Lymphoma according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1[alcl]4510.7TNFRSF8, BCL3, GZMB, CCL17, CCR4, TIA1
2larc4510.7CCR4, CCL17, CXCR3, CCL19, CCL20
3tarc4510.7CCL19, CCL20, CCR4, CXCR3, CCL17
4rantes4510.7CXCR3, GZMB, CCL20
5ccl345 2911.7CCL20, CCL19, CCL17, CXCR3, CCR4
6paraffin4510.7TNFRSF8, MS4A1, BCL6, GZMB, TIA1, NME1
7ccl445 2911.6CCR4, CCL20, CCL17, CXCR3
8teck4510.6CCR4, CXCL13, CCL19
9serine4510.6CXCR3, NME1, GZMB, ITK, TCL1A, BCL10
10calcium45 50 11 2413.6CCR4, MS4A1, CXCL13, CXCR3, NME1, CD19
11tyrosine4510.5TNFRSF8, BCL3, BCL6, NME1, CXCR3, CD19
12lipid4510.5CD19, MS4A1, TNFRSF8, GZMB, CCR4, BCL10
13allergens4510.5CXCR3, CCL17, CCL20
14peg-104510.4CXCL13, CCL19
15dexamethasone45 50 29 1113.4CXCR3, NME1, CCL20, CCL17, GZMB
16ricin4510.3CD19, TNFRSF8
17prednisolone45 29 1112.2TIA1, CCR4, GZMB

GO Terms for genes affiliated with Peripheral T-Cell Lymphoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Peripheral T-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.4MS4A1, CXCR3, CD19, CCR4

Biological processes related to Peripheral T-Cell Lymphoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1germinal center formationGO:00246710.6CXCL13, BCL6, BCL3
2immune responseGO:00695510.5MS4A1, TCF7, CXCL13, CCL17, CCL19, CCL20
3chemotaxisGO:00693510.5CXCR3, CCL17, CCL20, CCR4
4inflammatory responseGO:00695410.5CCR4, CCL20, CCL19, CCL17, CXCR3
5adaptive immune responseGO:00225010.5BCL10, ITK
6cellular defense responseGO:00696810.5BCL10, CD19, ITK
7elevation of cytosolic calcium ion concentrationGO:00720410.3CCR4, CXCR3, CXCL13
8defense response to bacteriumGO:04274210.1BCL3, CXCL13, CCL20

Molecular functions related to Peripheral T-Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:00495010.5CXCR3, CCR4
2chemokine activityGO:00800910.3CXCL13, CCL17, CCL19, CCL20
3CCR10 chemokine receptor bindingGO:03173510.1CXCL13, CCL19

Products for genes affiliated with Peripheral T-Cell Lymphoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Peripheral T-Cell Lymphoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet