Peripheral Vascular Disease malady

CDC: Peripheral Arterial Disease (PAD) in the Legs or lower extremities is the narrowing or blockage of the vessels that carry blood from the heart to the legs. It is primarily caused by the buildup of fatty plaque in the arteries, which is called atherosclerosis. PAD can occur in any blood vessel, but it is more common in the legs than the arms.²

MalaCards: Peripheral Vascular Disease, also known as peripheral vascular diseases, is related to thromboangiitis obliterans and vascular disease. An important gene associated with Peripheral Vascular Disease is PPBP (pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)), and among its related pathways are LDL-mediated lipid transport and Statin Pathway, Pharmacodynamics. The drugs niacin and nicotinic acid and the compounds clopidogrel and citrate have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and skeletal muscle, and related mouse phenotypes are respiratory system and hematopoietic system.

Wikipedia: Peripheral vascular disease (PVD), commonly referred to as peripheral arterial disease (PAD) or...⁴⁴ more...

Aliases & Descriptions:

peripheral vascular disease 6 8 peripheral vascular diseases 32 43

Diseases related to peripheral vascular disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 829)

id	Related Disease	Score	Top Affiliating Genes
1	thromboangiitis obliterans	30.1	SELE, SERPINE1, VCAM1, ICAM1, HTR2A, PLAT
2	vascular disease	29.4	VWF, SELE, SELP, SERPINC1, SERPINE1, VEGFA
3	arterial occlusive disease	28.8	VWF, SELE, SELP, VCAM1, F3, PLAT
4	thrombophilia	26.6	VWF, SELE, SELP, SERPINC1, SERPINE1, CETP
5	cytomegalovirus infection	26.3	VWF, SELE, SELP, VCAM1, MPO, IL18
6	peripheral arterial occlusive disease	26.0	VWF, SELE, SELP, SERPINE1, VCAM1, IL18
7	systemic lupus erythematosus	25.4	VWF, SELE, VCAM1, MPO, CD79A, CD4
8	proteinuria	21.4	COG2, VWF, SELP, SERPINC1, SERPINE1, VEGFA
9	pneumonia	20.1	COG2, SELE, SERPINC1, SERPINE1, VEGFA, VCAM1
10	type 2 diabetes mellitus	20.1	COG2, VWF, SELE, SELP, SERPINC1, SERPINE1
11	homocysteine	19.5	COG2, VWF, SELE, SELP, SERPINC1, SERPINE1
12	peritonitis	18.8	COG2, VWF, SELE, SELP, SERPINC1, SERPINE1
13	hypertension	18.7	COG2, VWF, SELE, SELP, SERPINC1, SERPINE1
14	diabetes mellitus	17.8	COG2, VWF, SELE, SELP, SERPINC1, SERPINE1
15	lupus erythematosus	17.8	COG2, VWF, SELE, SELP, SERPINC1, SERPINE1
16	nephropathy	17.6	COG2, VWF, SELE, SELP, SERPINE1, VEGFA
17	ischemia	17.3	COG2, VWF, SELE, SELP, SERPINC1, SERPINE1
18	mitral valve stenosis	13.8	SELP, PPBP, PF4
19	familial combined hyperlipidemia	13.8	APOA1, APOB, HMGCR
20	hypertensive nephropathy	13.8	ALB, ACE
21	apo a-i deficiency	13.8	APOA1, ALB
22	strawberry gallbladder	13.8	APOA1, APOB
23	familial hypertriglyceridemia	13.7	APOA1, APOA2, APOB
24	cerebrotendinous xanthomatosis	13.7	APOA1, APOB, HMGCR
25	amyloidosis, renal	13.7	MEFV, APOA1, APOA2
26	hypothyroidism	13.7	LPA, CETP, APOB
27	central serous chorioretinopathy	13.6	SERPINE1, PLAT
28	intermediate coronary syndrome	13.6	PLAT, PF4, ACE
29	abetalipoproteinemia	13.6	COG2, LPA, APOA1, APOB
30	alagille syndrome	13.6	LPA, APOA1, APOA2, ALB
31	hereditary diffuse leukoencephalopathy with spheroids	13.6	LPA, CETP, APOA1, APOA2, APOB
32	steroid-resistant nephrotic syndrome	13.6	ALB, PPBP, ACE
33	rheumatoid nodulosis	13.6	SELE, VCAM1
34	eisenmenger syndrome	13.6	VWF, ACE, THBD
35	erythromelalgia	13.6	PPBP, PF4, THBD
36	food allergy	13.6	CETP, MS4A2, ALB, ACE
37	cherubism	13.6	CETP, MEFV, APOB, NLRP3
38	allergic rhinitis	13.6	SELE, VCAM1, KNG1
39	arcus senilis	13.6	APOA1, APOB
40	myocardial infarction susceptibility	13.6	APOB, ACE, THBD
41	myocardial infarction	13.6	APOB, ACE, THBD
42	fish-eye disease	13.6	APOA1, APOA2
43	aneurysm disease	13.6	LPA, ACE, TIMP1
44	plasminogen activator inhibitor type 1 deficiency	13.6	SERPINE1, PLAT, KNG1
45	adult respiratory distress syndrome	13.6	SELE, PPBP, THBD
46	cetp deficiency	13.6	CETP, APOA1, APOA2, APOB, PLTP
47	norum disease	13.6	APOA1, APOA2
48	glanzmann's thrombasthenia	13.6	VWF, F3, PF4
49	ppm-x syndrome	13.5	VWF, HTR2A, HMGCR, ACE
50	berger disease	13.5	CD79A, PF4, ACE

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 cilostazol, cyclandelate, epoprostenol, epoprostenol sodium, niacin, niacin (as niacinamide), nicotinic acid, tolazoline, tolazoline hydrochloride

Cell-based therapeutics:

Endothelial progenitor cells, PMIDs: 10725398

MalaCards organs/tissues related to peripheral vascular disease:

²²

MGI Mouse Phenotypes related to peripheral vascular disease:

²⁵ (show all 18)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.3	SELP
2	hematopoietic system phenotype	MP:0005397	9.9	EPO, MEFV, BCL2L1
3	renal/urinary system phenotype	MP:0005367	9.7	TAC1, NLRP3, INS, SELP
4	reproductive system phenotype	MP:0005389	9.1	TIMP1, NLRP3, NOS2, PLTP, IL6, MEFV
5	digestive/alimentary phenotype	MP:0005381	8.1	NOS2, PLAT, F2, HTR2A, IL18, INS
6	tumorigenesis	MP:0002006	8.0	ACE, NOS2, TP53, F3, ICAM1, IL6
7	integument phenotype	MP:0010771	8.0	NLRP3, TP53, F2, F3, F5, MEFV
8	nervous system phenotype	MP:0003631	7.9	THBD, F2, F3, F5, INS, CD4
9	immune system phenotype	MP:0005387	7.8	PLAT, TP53, F2, APOA1, IL6, MEFV
10	liver/biliary system phenotype	MP:0005370	7.6	EPO, NLRP3, TP53, APOB, APOA1, IL6
11	behavior/neurological phenotype	MP:0005386	7.5	TAC1, ACE, NOS2, PLAT, HTR2A, F3
12	growth/size phenotype	MP:0005378	7.0	APOB, F3, TP53, PLAT, NLRP3, ACE
13	vision/eye phenotype	MP:0005391	6.9	ICAM1, F3, TP53, PLAT, PLTP, NOS2
14	normal phenotype	MP:0002873	6.2	ALB, HMGCR, TP53, NLRP3, THBD, EPO
15	mortality/aging	MP:0010768	6.0	F3, F2, HMGCR, TP53, PLAT, NOS2
16	cellular phenotype	MP:0005384	4.8	APOA1, ICAM1, F3, F2, TP53, PLAT
17	cardiovascular system phenotype	MP:0005385	3.8	EPO, VEGFA, SERPINE1, SERPINC1, SELP, SELE
18	homeostasis/metabolism phenotype	MP:0005376	2.0	VWF, APOA2, APOA1, IL6, IL18, MEFV

Articles related to peripheral vascular disease:

(show all 39)

id	Title	Authors	Year	Affiliating Genes
1	Lipoprotein(a) genetic variants associated with coron ary and peripheral vascular disease but not with stroke risk in the Heart Prote ction Study. (21252144)	Hopewell J.C.... Collins R.	2011	LPA
2	The difference between mean plasma levels of von Willebrand factor and platelet aggregation in type 2 diabetes mellitus with and without peripheral vascular disease at sardjito general hospital, yogyakarta. (19390122)	Renaldi O.... Purnomo L.B.	2009	VWF
3	Diabetes and peripheral vascular disease. (19994800)	Huysman E.... Mathieu C.	2009	INS
4	Markers of Chlamydia pneumoniae and human cytomegalovirus infection in patients with chronic peripheral vascular disease and their relation to inflammation, endothelial dysfunction and changes in lipid metabolism. (19381484)	Kraml P.J.... Andel M.	2008	VCAM1, IL18
5	ACE gene polymorphism in peripheral vascular disease. (17611909)	Basar Y.... Ozkok E.	2007	ACE
6	C-reactive protein (CRP) as a marker in peripheral vascular disease. (17296319)	Abdellaoui A.... Al-Khaffaf H.	2007	CRP
7	Blood-soluble Fas levels are increased in type 2 diabetic patients with peripheral vascular disease. (17075777)	GarcA-a-Unzueta M.T.... Amado J.A.	2006	ACE, CRP
8	The prevalence of thrombophilia in patients with symptomatic peripheral vascular disease. (16607693)	Vig S.... Halliday A.	2006	F2, SERPINC1, F5
9	Ischemia-modified albumin concentrations in patients with peripheral vascular disease and exercise-induced skeletal muscle ischemia. (15265817)	Roy D.... Kaski J.C.	2004	ALB
10	Altered platelet reactivity in peripheral vascular disease complicated with elevated plasma homocysteine levels. (15186948)	Riba R.... Naseem K.M.	2004	SELP
11	C-reactive protein and risk factors for peripheral vascular disease in subjects with Type 2 diabetes mellitus. (15049935)	Yu H.I.... Chen Y.T.	2004	CRP
12	Fibrinogen is a marker for nephropathy and peripheral vascular disease in type 1 diabetes: studies of plasma fibrinogen and fibrinogen gene polymorphism in the DCCT/EDIC cohort. (12716802)	Klein R.L.... Garvey W.T.	2003	ALB, FGB
13	The effect of peripheral vascular disease on the serum levels of natural anti-oxidants: bilirubin and albumin. (11941273)	Krijgsman B.... Hamilton G.	2002	ALB
14	Lack of association between angiotensin-converting enzyme gene polymorphism and peripheral vascular disease in type 2 diabetic patients in Taiwan. (12419932)	Tseng C.H.... Tseng C.P.	2002	ACE
15	Cost-minimization analysis of simvastatin versus atorvastatin for maintenance therapy in patients with coronary or peripheral vascular disease. (11293560)	Attanasio E.... Allen S.E.	2001	COG2
16	Coagulation, fibrinolysis and platelet P-selectin expression in peripheral vascular disease. (11237788)	Koksch M.... Ruehlmann C.	2001	PLAT
17	Thrombolytic and antiplatelet therapy in peripheral vascular disease with use of reteplase and/or abciximab. The SCVIR Consultants' Conference; May 22, 2000; Orlando, FL. Society for Cardiovascular and Interventional Radiology. (11435535)	Benenati J.... Seidl E.	2001	PLAT
18	Gene therapy for the treatment of peripheral vascular disease and coronary artery disease. (12847566)	Hedman M.... YlAo-Herttuala S.	2000	TP53, IL6, VEGFA
19	Prostaglandin E1-therapy reduces circulating adhesion molecules (ICAM-1, E-selectin, VCAM-1) in peripheral vascular disease. (11037715)	Palumbo B.... Sinzinger H.	2000	SELE, VCAM1
20	Net mass transfer of plasma cholesteryl esters and lipid transfer proteins in normolipidemic patients with peripheral vascular disease. (10582542)	Ruhling K.... Till U.	1999	PLTP, CETP
21	Short- and long-term treatments with iloprost in diabetic patients with peripheral vascular disease: effects on the cardiovascular risk factor plasminogen activator inhibitor type-1. (10501817)	Cozzolino D.... Torella R.	1999	SERPINE1
22	Association between human recombinant EPO and peripheral vascular disease in diabetic patients receiving peritoneal dialysis. (9740167)	Wakeen M.... Zimmerman S.W.	1998	EPO
23	Lipid levels and peripheral vascular disease in diabetic and non-diabetic subjects. (9544725)	O'Neal D.N.... Best J.D.	1998	APOA1
24	Plasma concentration of C-reactive protein and risk of developing peripheral vascular disease. (9490235)	Ridker P.M.... Hennekens C.H.	1998	CRP
25	Circulating endothelial cell markers in peripheral vascular disease: relationship to the location and extent of atherosclerotic disease. (9395787)	Blann A.D.... McCollum C.N.	1997	THBD
26	Lipid profile and peripheral vascular disease in arseniasis-hyperendemic villages in Taiwan. (9112880)	Tseng C.H.... Tai T.Y.	1997	APOA1, APOB
27	Lipoprotein (a) and its relationship to risk factors and severity of atherosclerotic peripheral vascular disease. (9290555)	Cheng S.W.... Wong J.	1997	APOB
28	Prevalence of renal artery stenosis in patients with peripheral vascular disease and hypertension. (8867560)	Wachtell K.... Lund J.O.	1996	ACE
29	Activated protein C resistance: prevalence and implications in peripheral vascular disease. (8558741)	Ouriel K.... Cimino C.	1996	F3
30	Soluble P selectin in peripheral vascular disease: relationship to the location and extent of atherosclerotic disease and its risk factors. (9034560)	Blann A.D.... McCollum C.N.	1996	SELP
31	The prevalence of peripheral vascular disease in type 2 diabetic patients with and without proteinuria. (7822899)	Migdalis I.N.... Samartzis M.	1994	ALB
32	Effects of lovastatin on high-density lipoprotein subfractions in hypercholesterolemic patients with peripheral vascular disease. (8434806)	Tilly-Kiesi M.... Tikkanen M.J.	1993	APOA2
33	Beneficial effects of a serine protease inhibitor in peripheral vascular disease. (8328387)	Urabe Y.... Arakawa K.	1993	KNG1, KLK15
34	Peripheral vascular disease in patients with systemic lupus erythematosus. (1540039)	McDonald J.... Gladman D.D.	1992	F3
35	Albumin excretion rate is not increased in atherosclerotic patients with peripheral vascular disease. (1821046)	Gruden G.... Cavallo-Perin P.	1991	ALB
36	Ketanserin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in hypertension and peripheral vascular disease. (2079001)	Brogden R.N.... Sorkin E.M.	1990	HTR2A
37	Renal artery stenosis and peripheral vascular disease: implications for ACE inhibitor therapy. (1974015)	Salmon P.... Brown M.A.	1990	ACE
38	ACE inhibitors and peripheral vascular disease. (1976165)	Walley T.... Roberts D.	1990	ACE
39	Beta-TG and plasma catecholamines levels after sympathetic stimuli in hypertensives and patients with peripheral vascular disease. (2144920)	Catalano M.... Libretti A.	1990	PPBP, PF4

Genes related to peripheral vascular disease according to GeneCards:

(show all 45)

id	Symbol	Description	Score	GeneCards Section Context
1	PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	11.0	Publications
2	PF4	platelet factor 4	11.0	Publications
3	CETP	cholesteryl ester transfer protein, plasma	11.0	Publications
4	LPA	lipoprotein, Lp(a)	11.0	Publications
5	SELE	selectin E	11.0	Publications
6	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	11.0	Publications
7	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
8	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0	Publications
9	ALB	albumin	11.0	Publications
10	APOA1	apolipoprotein A-I	11.0	Publications
11	VWF	von Willebrand factor	11.0	Publications
12	VCAM1	vascular cell adhesion molecule 1	11.0	Publications
13	APOB	apolipoprotein B (including Ag(x) antigen)	11.0	Publications
14	HMGCR	3-hydroxy-3-methylglutaryl-CoA reductase	11.0
15	KLK15	kallikrein-related peptidase 15	11.0	Publications
16	FGB	fibrinogen beta chain	11.0	Publications
17	APOA2	apolipoprotein A-II	11.0	Publications
18	MS4A2	membrane-spanning 4-domains, subfamily A, member 2	11.0
19	PLTP	phospholipid transfer protein	11.0	Publications
20	COG2	component of oligomeric golgi complex 2	11.0	Publications
21	TAC1	tachykinin, precursor 1	11.0
22	MEFV	Mediterranean fever	11.0
23	NLRP3	NLR family, pyrin domain containing 3	11.0
24	PLAT	plasminogen activator, tissue	11.0	Publications
25	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	11.0	Publications
26	THBD	thrombomodulin	11.0	Publications
27	BCL2L1	BCL2-like 1	11.0	Publications
28	TIMP1	TIMP metallopeptidase inhibitor 1	11.0	Publications
29	IL18	interleukin 18 (interferon-gamma-inducing factor)	11.0	Publications
30	KNG1	kininogen 1	11.0	Publications
31	F3	coagulation factor III (thromboplastin, tissue factor)	11.0	Publications
32	HTR2A	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	11.0	Publications
33	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
34	NOS2	nitric oxide synthase 2, inducible	11.0	Publications
35	ICAM1	intercellular adhesion molecule 1	11.0
36	VEGFA	vascular endothelial growth factor A	11.0	Publications
37	CD4	CD4 molecule	11.0
38	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0
39	F5	coagulation factor V (proaccelerin, labile factor)	11.0	Publications
40	F2	coagulation factor II (thrombin)	11.0	Publications
41	MPO	myeloperoxidase	11.0
42	EPO	erythropoietin	11.0	Publications
43	CRP	C-reactive protein, pentraxin-related	11.0	Publications
44	TP53	tumor protein p53	11.0	Publications
45	INS	insulin	11.0	Publications

Pathways related to peripheral vascular disease according to GeneDecks:

(show all 26)

id	Pathway	Score	Top Affiliating Genes
1	LDL-mediated lipid transport38	10.3	LPA, CETP
2	Statin Pathway, Pharmacodynamics34	10.3	PLTP, HMGCR, APOB, APOA1
3	Platelet activation, signaling and aggregation38	10.3	PF4, PPBP, APOA1, FGB, VWF
4	Selected targets of C/EBPbeta10	10.3	VWF, CETP, APOB, TAC1
5	Selected targets of C/EBPalpha10	10.3	ALB, APOB, CETP, SERPINC1
6	Development VEGF signaling and activation10	10.2	ICAM1, VCAM1, SELE
7	Cell adhesion molecules (CAMs)20	10.1	CD4, SELP
8	Development_VEGF signaling and activation41	9.9	ICAM1, VCAM1, VEGFA, SELE
9	Immune response IL-1 signaling pathway10	9.9	NOS2, F3, IL6, SERPINE1
10	Immune response_MIF-mediated glucocorticoid regulation41	9.9	NOS2, ICAM1, IL6, VCAM1
11	Immune response MIF-mediated glucocorticoid regulation10	9.8	NOS2, ICAM1, IL6, VCAM1
12	Immune response_IL-1 signaling pathway41	9.8	NOS2, F3, IL6, SERPINE1
13	African trypanosomiasis20	9.8	ICAM1, APOA1, IL6, IL18, VCAM1, SELE
14	Malaria20	9.8	ICAM1, IL6, IL18, VCAM1, SELP, SELE
15	NOD-like receptor signaling pathway20	9.8	MEFV, IL18, IL6, NLRP3
16	LDL Oxidation in Atherogenesis36	9.7	ICAM1, MPO, VCAM1
17	Immune System38	9.4	NLRP3, ICAM1, IL18, MEFV, CD79A, VCAM1
18	Intrinsic Prothrombin Activation Pathway36	9.4	THBD, KLK15, F2, F5, FGB, SERPINC1
19	Extrinsic Prothrombin Activation Pathway36	9.3	THBD, F2, F3, F5, FGB, SERPINC1
20	Blood Coagulation Cascade36	9.2	THBD, KLK15, F2, F3, F5, FGB
21	Selected targets of HNF110	9.1	CRP, ALB, APOB, APOA2, APOA1, INS
22	Cytokine-cytokine receptor interaction20	8.9	EPO, PF4, PPBP, IL6, IL18, VEGFA
23	Blood Coagulation Signaling Pathways37	8.7	VWF, KNG1, THBD, PLAT, F2, F3
24	Complement and coagulation cascades20	8.7	KNG1, THBD, PLAT, F2, F3, F5
25	JAK-STAT Pathway36	8.6	EPO, TIMP1, PPBP, F2, IL6, IL18
26	p38 Signaling36	8.2	TIMP1, PF4, PPBP, TP53, IL6, IL18

Compounds related to peripheral vascular disease according to GeneDecks:

(show top 50)    (show all 414)

id	Compound	Score	Top Affiliating Genes
1	clopidogrel32 34 9 18 9	14.4	ACE, PPBP, HMGCR, SERPINC1
2	citrate32	10.3	PF4, PPBP, CD79A, SELP
3	pge232	9.9	SELE, VCAM1, CD4, KNG1, PF4, PPBP
4	ristocetin32	9.8	VWF, SELP, SERPINC1, PLAT, PPBP, F2
5	polyethylene glycol32	9.8	THBD, PF4, APOA1, MPO, SERPINC1, SELE
6	hirudin32	9.7	F5, FGB, SERPINC1, PF4, TIMP1, THBD
7	tranexamic acid32 9 9	11.7	SERPINC1, VWF, SERPINE1, LPA, EPO, PLAT
8	iloprost32 42 9 9	12.6	THBD, PF4, PLAT, PPBP, F3, VCAM1
9	gemfibrozil32 9 9	11.4	PLAT, HMGCR, APOB, APOA2, APOA1, INS
10	pge132	9.3	KNG1, THBD, PF4, PLAT, PPBP, F5
11	ticlopidine32 9 9	11.3	PF4, PLAT, PPBP, HMGCR, F3, MPO
12	aprotinin32 9 9	11.2	F2, F5, SERPINC1, SELP, VWF, THBD
13	aspartate32	9.0	F2, F5, APOA1, IL18, CETP, SELP
14	protamine32	8.9	F3, F5, IL6, SERPINE1, SERPINC1, SELP
15	endotoxin32	8.9	PLTP, CRP, F3, F5, IL18, MEFV
16	perindopril32 34 9 9	11.9	VWF, SERPINE1, KNG1, THBD, ACE, PLAT
17	bezafibrate32 9 9	10.8	CRP, HMGCR, APOB, APOA2, APOA1, INS
18	mycophenolate mofetil32 9 9	10.8	EPO, THBD, ALB, F5, IL18, CD79A
19	gliclazide32 34 9 9	11.8	VEGFA, SELE, VCAM1, MPO, PLAT, ALB
20	bivalirudin32 9 9	10.8	THBD, PLAT, F2, F3, F5, MPO
21	polysulfone32	8.7	CRP, PPBP, ALB, F3, VCAM1, SELP
22	ramipril32 9 9	10.7	KNG1, ACE, CRP, HMGCR, ALB, INS
23	rosuvastatin32 34 9 9	11.7	COG2, CETP, INS, NOS2, CRP, HMGCR
24	ly29400232	8.5	TIMP1, NOS2, CRP, ICAM1, IL6, IL18
25	desmopressin32 42 9 9	11.4	EPO, THBD, PLAT, PPBP, F2, F3
26	8-isoprostane32	8.2	INS, MPO, VCAM1, SERPINE1, SELE, IL6
27	n acetylcysteine32	8.2	TIMP1, TP53, HMGCR, F2, IL18, CD79A
28	testosterone32 9 18 9	11.2	CETP, VCAM1, SERPINC1, SELE, COG2, CD79A
29	warfarin32 34 9 18 9	12.1	THBD, ACE, PF4, SERPINC1, SELP, VWF
30	vitamin b1232	7.9	APOA1, CD79A, MPO, LPA, VWF, APOB
31	fenofibrate32 9 9	9.8	INS, CETP, VCAM1, LPA, SERPINE1, SELP
32	kininogen32	7.8	PLAT, ALB, F2, F3, F5, APOB
33	folate32	7.6	EPO, THBD, TIMP1, CRP, ALB, F5
34	norepinephrine32 9 18 9	10.5	IL18, INS, CD79A, VCAM1, SELP, SELE
35	nitric oxide32 9 18 9	10.2	KNG1, TAC1, THBD, TIMP1, ACE, NOS2
36	histamine32 18	8.1	PF4, SELP, SELE, VWF, VCAM1, MPO
37	arginine32	7.0	KNG1, TAC1, THBD, TIMP1, PF4, HMGCR
38	heparin32 9 18 9	9.9	KNG1, TAC1, TIMP1, PPBP, CETP, LPA
39	lipid32	6.8	APOA2, APOA1, IL6, IL18, INS, CD4
40	prostacyclin32	6.7	APOA1, VCAM1, VEGFA, SERPINE1, SERPINC1, SELP
41	atorvastatin32 34 9 18 9	10.7	CRP, HMGCR, ICAM1, F5, APOB, APOA1
42	dexamethasone32 42 34 9 9	10.6	TAC1, THBD, TIMP1, NOS2, PPBP, VEGFA
43	aspirin32 34 18	8.4	SELE, VWF, COG2, SELP, KNG1, F5
44	simvastatin32 34 42 9 18 9	11.3	CETP, VCAM1, LPA, VEGFA, SERPINE1, SELP
45	cholesterol32 9 18 9	9.0	COG2, THBD, TIMP1, ACE, PF4, PLTP
46	cycloheximide32	6.0	ICAM1, APOB, IL6, IL18, CD4, BCL2L1
47	fibrinogen32	6.0	IL6, COG2, SELE, SELP, IL18, FGB
48	vegf32	5.7	F5, VWF, SELE, APOB, MPO, BCL2L1
49	lactate32	5.1	EPO, THBD, TIMP1, PF4, CRP, INS
50	serine32	4.9	KNG1, THBD, TIMP1, APOA1, IL18, FGB

Cellular components related to peripheral vascular disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	high-density lipoprotein particle	GO:034364	10.1	CETP, APOA1, APOA2
2	very-low-density lipoprotein particle	GO:034361	9.8	APOB, APOA2, APOA1
3	secretory granule	GO:030141	9.0	PLAT, APOA1, INS, MPO, VEGFA
4	platelet alpha granule lumen	GO:031093	9.0	KNG1, TIMP1, PF4, PPBP, ALB, F5
5	external side of plasma membrane	GO:009897	8.9	ACE, ICAM1, FGB, CD4, CD79A, MS4A2
6	endoplasmic reticulum lumen	GO:005788	8.9	F2, APOB, APOA2, APOA1, INS, CD4
7	plasma membrane	GO:005886	6.6	ICAM1, F3, HTR2A, F2, ACE, THBD
8	extracellular region	GO:005576	5.1	PLAT, CRP, PPBP, ALB, F2, F5
9	extracellular space	GO:005615	4.3	APOB, APOA1, IL6, IL18, FGB, INS

Biological processes related to peripheral vascular disease according to GeneDecks:

(show all 37)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of leukocyte migration	GO:002687	10.6	SELP, SELE
2	leukocyte tethering or rolling	GO:050901	10.5	VCAM1, SELP, SELE
3	cholesterol transport	GO:030301	10.5	APOB, APOA1, CETP
4	high-density lipoprotein particle remodeling	GO:034375	10.4	APOA2, APOA1, CETP
5	reverse cholesterol transport	GO:043691	10.3	CETP, APOA1, APOA2
6	leukocyte cell-cell adhesion	GO:007159	10.3	ICAM1, VCAM1, SELP, SELE
7	negative regulation of blood coagulation	GO:030195	10.2	KNG1, THBD, SERPINE1
8	cholesterol homeostasis	GO:042632	10.2	APOB, APOA2, APOA1, CETP
9	heterophilic cell-cell adhesion	GO:007157	10.2	SELE, SELP, VCAM1, ICAM1
10	lipoprotein metabolic process	GO:042157	10.2	ALB, APOB, APOA2, APOA1, CETP, LPA
11	cholesterol metabolic process	GO:008203	10.2	CETP, APOA1, APOA2, APOB
12	negative regulation of inflammatory response	GO:050728	10.2	SERPINC1, MEFV, APOA1, NLRP3
13	negative regulation of fibrinolysis	GO:051918	10.1	SERPINE1, F2, THBD
14	lipid metabolic process	GO:006629	10.1	PLTP, ALB, APOB, APOA2, APOA1, CETP
15	low-density lipoprotein particle remodeling	GO:034374	10.1	APOB, APOA2, MPO, CETP
16	cellular response to alkaloid	GO:071312	10.0	BCL2L1, ICAM1
17	fibrinolysis	GO:042730	10.0	PLAT, F2, SERPINE1
18	negative regulation of very-low-density lipoprotein particle remodeling	GO:010903	9.9	APOA1, APOA2
19	response to hyperoxia	GO:055093	9.9	EPO, IL18, SERPINE1
20	blood coagulation, intrinsic pathway	GO:007597	9.8	KNG1, F2, VWF
21	defense response to Gram-negative bacterium	GO:050829	9.8	NOS2, IL6, CD4, SERPINE1, SELP
22	cellular response to hydrogen peroxide	GO:070301	9.8	IL18, IL6, F3
23	response to glucocorticoid stimulus	GO:051384	9.7	PLAT, APOA2, IL6, SERPINE1
24	leukocyte migration	GO:050900	9.7	THBD, F2, ICAM1, APOB, SELP
25	negative regulation of proteolysis	GO:045861	9.6	PLAT, F2, INS
26	response to lipopolysaccharide	GO:032496	9.5	EPO, TAC1, THBD, F3, APOB, SELP
27	aging	GO:007568	9.4	EPO, TIMP1, HMGCR, HTR2A, F3, VCAM1
28	response to hypoxia	GO:001666	9.1	NOS2, PLAT, CRP, IL18, VCAM1, VEGFA
29	acute-phase response	GO:006953	9.0	INS, IL6, F2, CRP
30	platelet degranulation	GO:002576	9.0	KNG1, VWF, SELP, TIMP1, PF4, PPBP
31	inflammatory response	GO:006954	8.8	CRP, NLRP3, TAC1, KNG1, IL6, IL18
32	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	8.6	TP53, IL6, INS, CD4, VEGFA
33	cellular response to hypoxia	GO:071456	8.6	EPO, TP53, ICAM1, VEGFA
34	platelet activation	GO:030168	8.3	TIMP1, PF4, PPBP, ALB, F2, F5
35	positive regulation of cell proliferation	GO:008284	8.2	EPO, TIMP1, F2, HTR2A, IL6, INS
36	negative regulation of apoptotic process	GO:043066	7.8	TP53, PF4, TIMP1, EPO, ALB, IL6
37	blood coagulation	GO:007596	6.6	F3, F5, APOB, APOA1, FGB, VEGFA

Molecular functions related to peripheral vascular disease according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	high-density lipoprotein particle receptor binding	GO:070653	10.2	APOA1, APOA2
2	cholesterol transporter activity	GO:017127	10.2	APOB, APOA2, APOA1, CETP
3	oligosaccharide binding	GO:070492	10.2	SELP, SELE
4	cholesterol binding	GO:015485	9.7	CRP, APOA2, APOA1, CETP
5	cell surface binding	GO:043498	9.7	VEGFA, ICAM1, F3
6	eukaryotic cell surface binding	GO:043499	9.4	SELP, FGB, EPO
7	chaperone binding	GO:051087	9.4	VWF, FGB, ALB, TP53
8	transmembrane signaling receptor activity	GO:004888	9.3	THBD, ICAM1, CD4, CD79A, SELE
9	heparin binding	GO:008201	9.2	SELP, KNG1, PF4, APOB, MPO, LPA
10	protease binding	GO:002020	8.8	TP53, F3, INS, SERPINE1, SERPINC1
11	protein binding	GO:005515	3.8	F3, F2, ALB, TP53, CRP, PLAT