MCID: PRP027
MIFTS: 71

Peripheral Vascular Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Peripheral Vascular Disease

MalaCards integrated aliases for Peripheral Vascular Disease:

Name: Peripheral Vascular Disease 38 37 12 3 14
Peripheral Arterial Disease 38 40 3 59
Arterial Occlusive Diseases 51 41 69
Arterial Occlusive Disease 38 37 12
Peripheral Vascular Diseases 51 69
Helicobacter Infections 41 69
Pad 38 3
Peripheral Occlusive Disease 38
Peripheral Arterial Diseases 69

Classifications:



External Ids:

Disease Ontology 12 DOID:341
ICD9CM 34 443.81
SNOMED-CT 64 195624006 2929001
ICD10 32 I73.8

Summaries for Peripheral Vascular Disease

MedlinePlus : 40 Peripheral arterial disease (PAD) happens when there is a narrowing of the blood vessels outside of your heart. The cause of PAD is atherosclerosis. This happens when plaque builds up on the walls of the arteries that supply blood to the arms and legs. Plaque is a substance made up of fat and cholesterol. It causes the arteries to narrow or become blocked. This can reduce or stop blood flow, usually to the legs. If severe enough, blocked blood flow can cause tissue death and can sometimes lead to amputation of the foot or leg. The main risk factor for PAD is smoking. Other risk factors include older age and diseases like diabetes, high blood cholesterol, high blood pressure, heart disease, and stroke. Many people who have PAD don't have any symptoms. If you have symptoms, they may include Pain, numbness, achiness, or heaviness in the leg muscles. This happens when walking or climbing stairs. Weak or absent pulses in the legs or feet Sores or wounds on the toes, feet, or legs that heal slowly, poorly, or not at all A pale or bluish color to the skin A lower temperature in one leg than the other leg Poor nail growth on the toes and decreased hair growth on the legs Erectile dysfunction, especially among men who have diabetes PAD can increase your risk of heart attack, stroke, and transient ischemic attack. Doctors diagnose PAD with a physical exam and heart and imaging tests. Treatments include lifestyle changes, medicines, and sometimes surgery. Lifestyle changes include dietary changes, exercise, and efforts to lower high cholesterol levels and high blood pressure. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Peripheral Vascular Disease, also known as peripheral arterial disease, is related to peripheral artery disease and buerger disease, and has symptoms including edema, chest pain and angina pectoris. An important gene associated with Peripheral Vascular Disease is VWF (Von Willebrand Factor), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall. The drugs Methyltestosterone and Testosterone have been mentioned in the context of this disorder. Affiliated tissues include Bone, bone and heart, and related phenotypes are Decreased free cholesterol and cardiovascular system

Disease Ontology : 12 A vascular disease that is characterized by obstruction of larger arteries not within the coronary, aortic arch vasculature, or brain.

CDC : 3 Peripheral Arterial Disease (PAD) in the Legs or lower extremities is the narrowing or blockage of the vessels that carry blood from the heart to the legs. It is primarily caused by the buildup of fatty plaque in the arteries, which is called atherosclerosis. PAD can occur in any blood vessel, but it is more common in the legs than the arms.

PubMed Health : 59
About peripheral arterial disease: Peripheral arterial disease (P.A.D.) is a disease in which plaque (plak) builds up in the arteries that carry blood to your head, organs, and limbs. Plaque is made up of fat, cholesterol, calcium, fibrous tissue, and other substances in the blood.When plaque builds up in the body's arteries, the condition is called atherosclerosis (ATH-er-o-skler-O-sis). Over time, plaque can harden and narrow the arteries. This limits the flow of oxygen-rich blood to your organs and other parts of your body.P.A.D. usually affects the arteries in the legs, but it also can affect the arteries that carry blood from your heart to your head, arms, kidneys, and stomach. This article focuses on P.A.D. that affects blood flow to the legs.

Related Diseases for Peripheral Vascular Disease

Diseases related to Peripheral Vascular Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 307)
# Related Disease Score Top Affiliating Genes
1 peripheral artery disease 32.9 ACE APOB CRP IL6 SELP VCAM1
2 buerger disease 32.3 F2 SELE SERPINE1
3 ischemia 30.5 ACE PLAT SELP VEGFA
4 carotid stenosis 30.3 ACE CRP SELP
5 polyarteritis nodosa 30.0 CRP IL6 SELE
6 aortic aneurysm, familial abdominal, 1 30.0 ACE CRP IL6
7 critical limb ischemia 29.9 IL6 VEGFA
8 limb ischemia 29.9 ACE IL6 VEGFA VWF
9 diabetes mellitus 29.9 ACE ALB CRP IL6 VEGFA
10 vasculitis 29.8 CRP SELE THBD VCAM1 VWF
11 diabetic foot ulcers 29.7 CRP IL6
12 arteriosclerosis obliterans 29.5 IL6 SELP VCAM1
13 chronic kidney failure 29.5 ACE ALB CRP IL6 VCAM1
14 cytomegalovirus infection 29.4 IL6 SELE VCAM1
15 chronic venous insufficiency 29.4 PLAT SELP SERPINE1 VCAM1
16 peritonitis 29.4 ALB CRP F2 IL6
17 hypersplenism 29.4 ALB F2 SERPINC1
18 end stage renal failure 29.3 ACE ALB CRP IL6
19 hypercholesterolemia, familial 29.2 APOA1 APOB CRP LPA
20 ischemic heart disease 29.0 ACE APOA1 APOB CRP IL6
21 coronary heart disease 1 29.0 ACE APOA1 APOB CRP LPA SERPINE1
22 carotid artery disease 28.7 ACE APOA1 APOB CRP LPA SELE
23 intermittent claudication 28.6 ACE ALB CRP F2 IL6 SELP
24 atrial fibrillation 28.4 ACE F2 PLAT PPBP SELP VWF
25 venous insufficiency 28.4 CRP F2 PLAT SELP SERPINE1 VCAM1
26 body mass index quantitative trait locus 11 28.2 APOA1 APOB CRP IL6 LPA SELE
27 antiphospholipid syndrome 28.2 F2 F3 PLAT SELE SELP SERPINC1
28 coronary artery anomaly 28.2 ACE APOA1 APOB CRP IL6 LPA
29 acute myocardial infarction 28.2 ACE CRP F3 PLAT SELP SERPINC1
30 angina pectoris 28.1 ACE CRP F3 IL6 PLAT SERPINC1
31 thrombophilia due to thrombin defect 28.0 F2 F3 PLAT SERPINC1 SERPINE1 THBD
32 thrombosis 28.0 F2 F3 PLAT SELP SERPINC1 SERPINE1
33 heart disease 27.9 ACE ALB APOB CRP F2 F3
34 systemic lupus erythematosus 27.8 ALB CRP F2 F3 IL6 SELE
35 thrombophilia 27.0 F2 F3 PLAT PPBP SERPINC1 SERPINE1
36 vascular disease 26.9 ACE APOA1 APOB CRP F3 LPA
37 arteriosclerosis 26.3 ACE APOA1 APOB CRP F3 IL6
38 arteries, anomalies of 25.4 ACE ALB APOA1 APOB CRP F2
39 myocardial infarction 24.3 ACE ALB APOA1 APOB CRP F2
40 peripheral arterial occlusive disease 1 12.4
41 grange syndrome 11.4
42 priapism 10.8
43 unilateral absence of a pulmonary artery 10.6 THBD VWF
44 generalized atherosclerosis 10.5 ACE CRP SELP
45 anterolateral myocardial infarction 10.5 ACE PLAT
46 hypertensive nephropathy 10.5 ACE ALB VEGFA
47 mercury poisoning 10.5 PLAT THBD
48 infiltrating angiolipoma 10.5 VEGFA VWF
49 eisenmenger syndrome 10.4 PLAT THBD VWF
50 hepatopulmonary syndrome 10.4 ALB VEGFA VWF

Comorbidity relations with Peripheral Vascular Disease via Phenotypic Disease Network (PDN): (show top 50) (show all 98)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Myocardial Infarction
Acute Vascular Insufficiency of Intestine Anxiety
Aortic Aneurysm Aortic Atherosclerosis
Aortic Valve Disease 1 Autonomic Nervous System Disease
Basilar Artery Insufficiency Benign Essential Hypertension
Benign Renovascular Hypertension Bleeding Disorder, Platelet-Type, 11
Bronchitis Bronchopneumonia
Buerger Disease Cardiac Arrest
Cardiogenic Shock Cerebral Atherosclerosis
Cerebrovascular Disease Chronic Intestinal Vascular Insufficiency
Chronic Kidney Failure Chronic Myocardial Ischemia
Chronic Pulmonary Heart Disease Chronic Ulcer of Skin
Decubitus Ulcer Deficiency Anemia
Dermatomycosis Diabetic Peripheral Angiopathy
Diabetic Polyneuropathy Dressler's Syndrome
Dysthymic Disorder Encephalopathy
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Esophagitis
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Gas Gangrene Generalized Atherosclerosis
Gout Heart Disease
Hyperlipoproteinemia, Type Iv Hyperlipoproteinemia, Type V
Hypertension, Essential Hypertensive Encephalopathy
Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome Hypoglycemia
Hypoglycemic Coma Hypothyroidism

Graphical network of the top 20 diseases related to Peripheral Vascular Disease:



Diseases related to Peripheral Vascular Disease

Symptoms & Phenotypes for Peripheral Vascular Disease

UMLS symptoms related to Peripheral Vascular Disease:


edema, chest pain, angina pectoris

GenomeRNAi Phenotypes related to Peripheral Vascular Disease according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 8.92 APOA1 APOB LPA SELP

MGI Mouse Phenotypes related to Peripheral Vascular Disease:

43 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.44 VCAM1 VEGFA THBD VWF F3 APOA1
2 homeostasis/metabolism MP:0005376 10.39 VCAM1 VEGFA THBD VWF F3 APOA1
3 immune system MP:0005387 10.31 VCAM1 SERPINE1 VEGFA THBD VWF F3
4 cellular MP:0005384 10.3 VWF VCAM1 VEGFA THBD ALB APOA1
5 hematopoietic system MP:0005397 10.29 VWF VCAM1 SERPINE1 VEGFA THBD F3
6 growth/size/body region MP:0005378 10.27 THBD VCAM1 SERPINE1 VEGFA F3 APOB
7 mortality/aging MP:0010768 10.2 VWF VCAM1 SERPINE1 VEGFA THBD F3
8 liver/biliary system MP:0005370 10.11 SERPINE1 VEGFA THBD APOA1 APOB IL6
9 integument MP:0010771 10.1 SERPINE1 VEGFA THBD APOA1 F3 F2
10 digestive/alimentary MP:0005381 10.05 THBD VWF VEGFA F2 ALB PLAT
11 renal/urinary system MP:0005367 9.86 SERPINE1 VEGFA THBD ALB ACE SERPINC1
12 reproductive system MP:0005389 9.81 THBD VCAM1 VEGFA APOB ACE F2
13 respiratory system MP:0005388 9.61 SERPINE1 VEGFA THBD F3 F2 SELE
14 vision/eye MP:0005391 9.23 VEGFA F3 APOB PLAT SERPINC1 SELE

Drugs & Therapeutics for Peripheral Vascular Disease

PubMedHealth treatment related to Peripheral Vascular Disease: 59

Treatments for peripheral arterial disease (P.A.D.) include lifestyle changes, medicines, and surgery or procedures.The overall goals of treating P.A.D. include reducing symptoms, improving quality of life, and preventing complications. Treatment is based on your signs and symptoms, risk factors, and results from a physical exam and tests.Treatment may slow or stop disease progress and reduce the risk of complications. Without treatment, P.A.D. can cause sores or gangrene (tissue death). In extreme cases, it may be necessary to remove part of the leg or foot (amputation).

Drugs for Peripheral Vascular Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 474)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyltestosterone Approved Phase 4 58-18-4 6010
2
Testosterone Approved, Investigational Phase 4 58-22-0 6013
3
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-78-2 2244
4
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Early Phase 1 120202-66-6, 113665-84-2 60606
5
Cilostazol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 73963-72-1 2754
6
Paclitaxel Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 33069-62-4 36314
7
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
8
Metformin Approved Phase 4,Phase 3 657-24-9 4091 14219
9
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3 38396-39-3, 2180-92-9 2474
10
Clonidine Approved Phase 4 4205-90-7 2803
11
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
12
Morphine Approved, Investigational Phase 4 57-27-2 5288826
13
Angiotensin II Approved, Investigational Phase 4,Phase 2,Early Phase 1 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
14
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 158781 130881
15
Simvastatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 79902-63-9 54454
16
Dalteparin Approved Phase 4,Phase 3,Phase 1 9005-49-6
17
Heparin Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 9005-49-6 46507594 772
18
Nitric Oxide Approved Phase 4,Phase 2,Early Phase 1 10102-43-9 145068
19
Menthol Approved Phase 4,Phase 2,Phase 3 2216-51-5 16666
20
Alprostadil Approved, Investigational Phase 4,Phase 3,Phase 2 745-65-3 149351
21
Everolimus Approved Phase 4,Phase 2,Phase 3,Phase 1 159351-69-6 6442177
22
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 22916-47-8 4189
23
Sirolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 53123-88-9 46835353 6436030 5284616
24
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 137-58-6 3676
25
Nitroglycerin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 55-63-0 4510
26
Pravastatin Approved Phase 4,Phase 3,Phase 1 81093-37-0 54687
27
Metoprolol Approved, Investigational Phase 4,Phase 3,Phase 1 51384-51-1, 37350-58-6 4171
28
Allopurinol Approved Phase 4 315-30-0 2094
29
Ramipril Approved Phase 4 87333-19-5 5362129
30
Ezetimibe Approved Phase 4,Phase 3 163222-33-1 150311
31
Ticlopidine Approved Phase 4,Phase 3,Phase 2 55142-85-3 5472
32 Defibrotide Approved, Investigational Phase 4 83712-60-1
33
Iloprost Approved, Investigational Phase 4,Phase 3,Phase 2 78919-13-8 6443959
34
Pentoxifylline Approved, Investigational Phase 4,Phase 3 6493-05-6 4740
35
Amlodipine Approved Phase 4,Phase 2,Phase 3 88150-42-9 2162
36
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
37
Pioglitazone Approved, Investigational Phase 4,Phase 2,Phase 3,Early Phase 1 111025-46-8 4829
38
Valsartan Approved, Investigational Phase 4,Phase 2 137862-53-4 60846
39
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
40
Insulin Glargine Approved Phase 4 160337-95-1
41
Insulin Lispro Approved Phase 4 133107-64-9
42
Zinc Approved, Investigational Phase 4,Phase 1 7440-66-6 32051 23994
43
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
44
Ibuprofen Approved Phase 4 15687-27-1 3672
45
Vorapaxar Approved Phase 4,Phase 3 618385-01-6
46
Thrombin Approved, Investigational Phase 4,Phase 3,Phase 2
47
Ticagrelor Approved Phase 4,Phase 3,Phase 2,Phase 1 274693-27-5 9871419
48
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
49
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
50
Lisinopril Approved, Investigational Phase 4 83915-83-7, 76547-98-3 5362119

Interventional clinical trials:

(show top 50) (show all 1227)

# Name Status NCT ID Phase Drugs
1 Testosterone for Peripheral Vascular Disease Unknown status NCT00504712 Phase 4 Testosterone;0.9% saline
2 Multifactorial Intervention on Cardiovascular Risk Factors in Subjects With Peripheral Arterial Disease Unknown status NCT00144937 Phase 4 Stepwise therapy for dyslipidemia, hypertension and diabetes
3 Residual Platelet Activity In Advanced Peripheral Artery Disease Unknown status NCT01627431 Phase 4 Acetylsalicylic acid;Clopidogrel
4 A Multicenter, Therapeutic Used Study to Evaluate the Efficacy and Safety of Pletaal SR Capsule (Cilostazol) in Subjects With Peripheral Arterial Disease Symptom Due to Chronic Occlusive Arterial Disease Unknown status NCT01711333 Phase 4 Pletaal SR capsule
5 Paclitaxel Eluting Balloon and Conventional Balloon for In-Stent Restenosis of the Superficial Femoral Artery Unknown status NCT01083394 Phase 4
6 Efficacy Study of Stenting, Paclitaxel Eluting Balloon or Atherectomy to Treat Peripheral Artery Disease Unknown status NCT00986752 Phase 4
7 Efficacy of Self-Expanding Nitinol S.M.A.R.T CONTROL Stent Versus Life Stent For The Atherosclerotic Femoro-Popliteal Arterial Disease Unknown status NCT01653600 Phase 4
8 Platelets Induced Vasodilation, in Vitro and in Vivo Study Unknown status NCT00152646 Phase 4 placebo, aspirine, clopidogrel
9 Paclitaxel Eluting Stent or Exercise for Thigh Atherosclerosis Unknown status NCT02033135 Phase 4
10 Metformin, Muscle Energetics, and Vascular Function in Older Adults With Peripheral Artery Disease Unknown status NCT01901224 Phase 4 Metformin 1000 mg;Placebo
11 Prevena Vascular Groin Wound Study Unknown status NCT02581904 Phase 4
12 Aspirin Resistance and Prognosis of Patients With Critical Limb Ischaemia Unknown status NCT01104441 Phase 4
13 Safety and Efficacy Study of OmniWave Endovascular System to Treat Deep Vein Thrombosis Unknown status NCT00640731 Phase 4
14 Drug Eluting Balloon in peripherAl inTErvention for Below-The-Knee Arteries With Freeway and Lutonix Unknown status NCT02279784 Phase 4
15 Paclitaxel-eluting Balloon Angioplasty With Provisional Use of Nitinol Stent Versus Systematic Implantation of Paclitaxel-eluting Stent for the Treatment of Femoropopliteal de Novo Lesions Unknown status NCT01969630 Phase 4
16 Far Infrared Therapy on Peripheral Artery Disease in Hemodialysis Patients Unknown status NCT01095549 Phase 4
17 Interest of a Bi-truncal Nerve Block (Femoral + Sciatic) Extended, Systematically Associated With General Anesthesia, in the Femoropopliteal Bypass: Study of Post-operative Analgesia and Peripheral Circulation Downstream Unknown status NCT01785693 Phase 4 levobupivacaine, clonidine
18 Cilostazol Versus Aspirin for Primary Prevention of Atherosclerotic Events Unknown status NCT00886574 Phase 4 Cilostazol;Aspirin
19 Effect of olmesaRtan on Walking distancE and quaLIty of lifE in Peripheral Artery Disease Patients With Hypertension Treated For Intermittent Claudication (RELIEF) Unknown status NCT02373462 Phase 4 Olmesartan;other anti-hypertensive drug
20 Effects of Nicotinic Acid Plus Simvastatin Versus Simvastatin Alone on Carotid and Femoral Intima-Media Thickness in Patients With Peripheral Artery Disease (NASCIT) Unknown status NCT00712049 Phase 4 simvastatin;Nicotinic Acid
21 Efficacy of Low Molecular Weight Heparin in Superficial Vein Thrombosis Unknown status NCT01245998 Phase 4 Dalteparin;Dalteparin
22 Clinical Evaluation of the SNaP Wound Care System Unknown status NCT01113658 Phase 4
23 Long-term Pleiotropic Effect of Statins in Patients With Peripheral Arterial Disease Completed NCT01041729 Phase 4 Atorvastatin;Standard Medical Treatment
24 Effects of Cilostazol on VEGF and Oxidative Stress Biomarkers in Hemodialysis Patients With Peripheral Vascular Disease Completed NCT00431249 Phase 4 Cilostazol
25 Prevention of Ischemic Events in Patients With Peripheral Arterial Disease Completed NCT00761969 Phase 4
26 Allopurinol as a Possible Oxygen Sparing Agent During Exercise in Peripheral Arterial Disease Completed NCT01147705 Phase 4 Allopurinol;Placebo
27 Angiotensin Converting Enzyme (ACE) Inhibition and Peripheral Arterial Disease Completed NCT00681226 Phase 4 Ramipril or matching placebo
28 Intermittent Mechanical Compression For Peripheral Arterial Disease Completed NCT00855673 Phase 4 Control
29 Effectiveness of Intensive Lipid Modification Medication in Preventing the Progression of Peripheral Arterial Disease (The ELIMIT Study) Completed NCT00687076 Phase 4 Ezetimibe;Niaspan;Statin therapy;Aspirin;Clopidogrel;Placebo Niaspan;Placebo Ezetimibe
30 The Effects of Ramipril on Clinical Symptoms in Patients With Peripheral Arterial Disease Completed NCT00168467 Phase 4 Ramipril
31 The Effects of Physical Training, ASA (Aspirin), and Clopidogrel on the Walking Capacity of Patients With Stage II Peripheral Arterial Disease (PAD) Completed NCT00189618 Phase 4 Aspirin;Clopidogrel
32 GORE VIABAHN ENDOPROSTHESIS Peripheral Vascular Disease Study Completed NCT00228384 Phase 4
33 Testosterone Replacement in Diabetes With Vascular Disease (Version 2) Completed NCT00355537 Phase 4 Testosterone;0.9% saline
34 The Jetstream G3™ Calcium Study Completed NCT01273623 Phase 4
35 The Safety and Efficacy of Cilostazol in Ischemic Stroke Patients With Peripheral Arterial Disease (SPAD Study) Completed NCT01188824 Phase 4 Cilostazol
36 A Study to Collect Intravascular Ultrasound Images Before and After Treatment With the Jetstream System Completed NCT00911417 Phase 4
37 Efficacy Evaluation of Dotarem Compared to Gadovist in the Diagnosis of Peripheral Arterial Disease Completed NCT01026389 Phase 4 Dotarem;Gadovist
38 Angioplasty in Peripheral Arterial Disease and Endothelial Function Completed NCT00660634 Phase 4
39 GORE VIABAHN® Versus Plain Old Balloon Angioplasty (POBA) for Superficial Femoral Artery (SFA) In-Stent Restenosis Completed NCT01108861 Phase 4
40 The Jetstream (JET) Post-market Registry Completed NCT01436435 Phase 4
41 4-EVER : a Trial Investigating the Safety of 4F Endovascular Treatment of Infra-Inguinal Arterial Stenotic Disease Completed NCT01413139 Phase 4
42 Peripheral Vascular Disease and Nerve Stimulation Completed NCT01942941 Phase 4
43 NanoCross BTK, a Prospective, Non-randomized, Multicenter, Controlled Trial Evaluating the Performance of the NanoCrossTM .014 Balloon Catheter in Infrapopliteal Lesions Completed NCT01783600 Phase 4
44 Drug Eluting Balloon in peripherAl inTErvention SFA Completed NCT01556542 Phase 4
45 Prospective, Non-randomized Multi-center, Controlled Physician-initiated Trial: Rotarex Belgium In-stent Occlusion Completed NCT02212626 Phase 4
46 Physician-Initiated Trial Investigating the BeGraft Peripheral Stent Graft System Completed NCT02211716 Phase 4
47 Standard Balloon Angioplasty Versus Angioplasty With a Paclitaxel-eluting Balloon for Femoral Artery In-stent Restenosis Completed NCT01305070 Phase 4
48 ASSESS Study: Evaluation of ABSOLUTE™ Stent System for Occluded Arteries Completed NCT00180505 Phase 4
49 DOTAREM®-Enhanced MRA Compared to GADOVIST®-Enhanced MRA in Patients With Abdominal or Lower Limb Arterial Diseases Completed NCT00955617 Phase 4
50 Effect of Cilostazol Endothelial Progenitor Cells and Collateral Formation in Peripheral Occlusive Artery Disease (PAOD) Completed NCT01952756 Phase 4 Cilostazol;Dummy Placebo

Search NIH Clinical Center for Peripheral Vascular Disease

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Peripheral Vascular Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Peripheral Vascular Disease:
ACY001, bone marrow-derived hematopoietic stem cells for coronary artery occlusions
ALD-301, bone marrow-derived cells for critical limb ischemia
Alecmestencel-T, mesenchymal stem cells for ischemic diseases
ALO212, umbilical cord blood-derived stem cell concentrate for vascular diseases
Autologus endothelial progenitor cells for the treatment of critical limb ischemia
Autologus hematopoeitic stem cells for the treatment of critical limb ischemia
Bone marrow-derived CD133+ or nucleated cells for peripheral artery disease
Bone marrow-derived mononuclear cells for peripheral vascular disease
Bone marrow-derived mononuclear stem cells for treatment of critical limb ischemia
Endothelial progenitor cells for peripheral artery disease
Enriched bone marrow-derived progenitor cells for ischemic diseases
MultiGeneAngio, genetically modified endothelial and smooth muscle cells for vascular disease
MultiStem
Peripheral blood-derived hematopoietic stem cells for leg gangrene
TGI PVG, adipose-derived stem cell-coated vascular graft for peripheral vascular disease
VASCUGEL
Embryonic/Adult Cultured Cells Related to Peripheral Vascular Disease:
Bone marrow-derived CD133+ stem cells
Bone marrow-derived ALDH+ cells (ALD) PMIDs: 10430905 19324906
Bone marrow-derived mesenchymal stem cells (family)
Cord blood-derived hematopoietic stem cell PMIDs: 19558779
Peripheral blood-derived endothelial cells PMIDs: 19448678 18388019
Peripheral blood-derived hematopoietic stem cells PMIDs: 18388019
Bone marrow-derived mononuclear cells (family)
Bone marrow-derived mononuclear cells
Bone marrow-derived mononuclear cells
Peripheral blood-derived endothelial progenitor cells PMIDs: 10725398
Bone marrow-derived progenitor cells
MultiGeneAngio, transduced vein-derived endothelial cells
MultiGeneAngio, transduced vein-derived smooth muscle cells
Genetically modified vein-derived smooth muscle
Genetically modified vein-derived endothelial cells
Bone marrow-derived adherent progenitor cells (MultiStem) PMIDs: 21175285 23307829
Peripheral blood-derived hematopoietic stem cells
Adipose-derived stromal cells PMIDs: 8207032 23350681
Aortic endothelial cells cultured in matrix PMIDs: 7667257
Aortic endothelial cells cultured in matrix (VASCUGEL PMIDs: 7667257

Cochrane evidence based reviews: arterial occlusive diseases

Genetic Tests for Peripheral Vascular Disease

Anatomical Context for Peripheral Vascular Disease

MalaCards organs/tissues related to Peripheral Vascular Disease:

38
Bone, Heart, Endothelial, Bone Marrow, Testes, Kidney, Skin
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Peripheral Vascular Disease:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate

Publications for Peripheral Vascular Disease

Articles related to Peripheral Vascular Disease:

(show top 50) (show all 594)
# Title Authors Year
1
Peripheral Vascular Disease: The Beneficial Effect of Exercise in Peripheral Vascular Diseases Based on Clinical Trials. ( 29098622 )
2017
2
Polyarteritis nodosa presenting as peripheral vascular disease and acute limb ischemia. ( 28397742 )
2017
3
Peripheral Vascular Disease in Patients with Diabetic Foot Ulcers - An Emerging Trend: A Prospective Study from North India. ( 28598042 )
2017
4
Osseointegrated Transtibial Implants in Patients with Peripheral Vascular Disease: A Multicenter Case Series of 5 Patients with 1-Year Follow-up. ( 28926380 )
2017
5
Marrow-isolated adult multilineage inducible cells embedded within a biologically-inspired construct promote recovery in a mouse model of peripheral vascular disease. ( 28211362 )
2017
6
Ethnic differences in the association between angiotensin-converting enzyme gene insertion/deletion polymorphism and peripheral vascular disease: A meta-analysis. ( 29354806 )
2017
7
Insidious incrementalism: The silent failure of the microcirculation with increasing peripheral vascular disease risk. ( 28236373 )
2017
8
Transverse versus Longitudinal Incisions for Femoral Artery Exposure in Treating Patients with Peripheral Vascular Disease. ( 28890060 )
2017
9
Polyarteritis nodosa presenting as peripheral vascular disease and acute limb ischemia. ( 27853042 )
2017
10
Peripheral Vascular Disease and Death in Southern European Kidney Transplant Candidates: A Competing Risk Modeling Approach: Erratum. ( 28738405 )
2017
11
Social, demographic and clinical characteristics of patients suffering from peripheral vascular disease treated surgically compared to patients treated with endovascular angioplasty. ( 28905042 )
2017
12
Serum Interleukin-23 in Polish Patients with Systemic Lupus Erythematosus: Association with Lupus Nephritis, Obesity, and Peripheral Vascular Disease. ( 29430084 )
2017
13
Allopurinol and peripheral vascular disease: enough observational data to warrant interventional studies: Allopurinol and the prevention of vascular disease. ( 28968915 )
2017
14
Use of p53-Silenced Endothelial Progenitor Cells to Treat Ischemia in Diabetic Peripheral Vascular Disease. ( 28365567 )
2017
15
Efficacy and safety of aspirin in patients with peripheral vascular disease: An updated systematic review and meta-analysis of randomized controlled trials. ( 28403216 )
2017
16
Peripheral Vascular Disease: Treatment in Older Adults. ( 28145673 )
2017
17
The Role of the Profundoplasty in the Modern Management of Patient with Peripheral Vascular Disease. ( 28549963 )
2017
18
Wearable Sensor Technology Efficacy in Peripheral Vascular Disease (wSTEP): A Randomized Controlled Trial. ( 28498233 )
2017
19
Reply to Letter to Editor regarding the article, "Polyarteritis nodosa presenting as peripheral vascular disease and acute limb ischemia". ( 28397743 )
2017
20
Diabetes mellitus is a coronary heart disease risk equivalent for peripheral vascular disease. ( 28224925 )
2017
21
Non-reconstructable peripheral vascular disease of the lower extremity in ten patients treated with adipose-derived stromal vascular fraction cells. ( 27984756 )
2017
22
Prevalence of Subclinical Peripheral Vascular Disease in Obese Egyptian Patients. ( 29142342 )
2017
23
Evaluation of hyperspectral imaging technology in patients with peripheral vascular disease. ( 28545710 )
2017
24
Hemorheological parameters better classify metabolic syndrome than novel cardiovascular risk factors and peripheral vascular disease marker. ( 26890105 )
2016
25
Increased peripheral vascular disease risk progressively constrains perfusion adaptability in the skeletal muscle microcirculation. ( 26702145 )
2016
26
Comparison of colour duplex ultrasound & ankle brachial index in peripheral vascular disease in type 2 diabetes. ( 27727957 )
2016
27
Neutrophil lymphocyte ratio in peripheral vascular disease: a review. ( 26967241 )
2016
28
Peripheral vascular disease in diabetic foot- A new trend. ( 27727607 )
2016
29
Transcatheter Aortic Valve Implantation in Patients With Arterial Peripheral Vascular Disease. ( 27884643 )
2016
30
Association between Bacterial Infection and Peripheral Vascular Disease: A Review. ( 26900306 )
2016
31
Identifying beliefs about smoking in patients with peripheral vascular disease. ( 27863591 )
2016
32
Novel Applications of Radionuclide Imaging in Peripheral Vascular Disease. ( 26590787 )
2016
33
Trimetazidine hydrochloride as a new treatment for patients with peripheral vascular disease--an exploratory trial. ( 26813473 )
2016
34
Mortality After Nontraumatic Major Amputation Among Patients WithA Diabetes and Peripheral Vascular Disease: A Systematic Review. ( 26898398 )
2016
35
Mitochondrial Respiration after One Session of Calf Raise Exercise in Patients with Peripheral Vascular Disease and Healthy Older Adults. ( 27760222 )
2016
36
SPECT and PET imaging of angiogenesis and arteriogenesis in pre-clinical models of myocardial ischemia and peripheral vascular disease. ( 27517840 )
2016
37
Evaluation of a novel 2D perfusion angiography technique independent of pump injections for assessment of interventional treatment of peripheral vascular disease. ( 27785678 )
2016
38
Anesthesia for Patients with Peripheral Vascular Disease and Cardiac Dysfunction. ( 27816134 )
2016
39
Treatment of a High-Risk Diabetic Patient with Peripheral Vascular Disease and Osteomyelitis. ( 27423990 )
2016
40
An Experimental Model of Peripheral Vascular Disease Involving the Intravenous Injection of Oral Bacteria. ( 28018496 )
2016
41
Utility of Indocyanine Green Angiography in Arterial Selection during Free Flap Harvest in Patients with Severe Peripheral Vascular Disease. ( 27826489 )
2016
42
Prevalence of asymptomatic peripheral vascular disease in patients with type-2 diabetes mellitus by colour doppler study. ( 27728049 )
2016
43
Ventricular Tachycardia: Inferior Vena Cava Filter in a Case of Peripheral Vascular Disease. ( 26794288 )
2016
44
The Discovery of Novel Genomic, Transcriptomic, and Proteomic Biomarkers in Cardiovascular and Peripheral Vascular Disease: The State of the Art. ( 27298828 )
2016
45
Peripheral Vascular Disease and Death in Southern European Kidney Transplant Candidates: A Competing Risk Modeling Approach. ( 27379552 )
2016
46
Assessment of risk of peripheral vascular disease and vascular care capacity in a low- and middle-income country. ( 26560502 )
2015
47
Peripheral vascular disease: shaping a new panvascular interventional approach. ( 26603982 )
2015
48
Nanoscale Strategies: Treatment for Peripheral Vascular Disease and Critical Limb Ischemia. ( 25844518 )
2015
49
Comparison of vancomycin and linezolid in patients with peripheral vascular disease and/or diabetes in an observational European study of complicated skin and soft-tissue infections due to methicillin-resistant Staphylococcus aureus. ( 26198370 )
2015
50
A systematic review of the incidence and prevalence of cardiac, cerebrovascular, and peripheral vascular disease in multiple sclerosis. ( 25533300 )
2015

Variations for Peripheral Vascular Disease

Expression for Peripheral Vascular Disease

Search GEO for disease gene expression data for Peripheral Vascular Disease.

Pathways for Peripheral Vascular Disease

Pathways related to Peripheral Vascular Disease according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.55 ALB APOA1 APOB F2 F3 PLAT
2
Show member pathways
12.15 APOB F2 SELE SELP THBD
3
Show member pathways
12.09 ALB APOA1 APOB CRP F2 IL6
4
Show member pathways
12.07 F2 F3 PLAT SERPINC1 SERPINE1 THBD
5 12 PLAT SELE THBD VCAM1 VEGFA
6 11.94 ALB IL6 VCAM1 VEGFA
7 11.94 F2 F3 PLAT SERPINC1 SERPINE1 THBD
8
Show member pathways
11.58 IL6 SELE VCAM1 VEGFA
9 11.5 F3 IL6 SELE SERPINE1 THBD VCAM1
10 11.45 APOB IL6 LPA PLAT SELP
11 11.42 IL6 SELE SELP VCAM1
12 11.34 ALB APOA1 F2
13 11.25 APOA1 IL6 SELE VCAM1
14 10.65 PLAT SERPINE1

GO Terms for Peripheral Vascular Disease

Cellular components related to Peripheral Vascular Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.85 APOA1 F3 PLAT THBD VCAM1 VEGFA
2 extracellular region GO:0005576 9.83 ACE ALB APOA1 APOB CRP F2
3 extracellular matrix GO:0031012 9.8 APOA1 F3 PLAT SERPINE1 VWF
4 external side of plasma membrane GO:0009897 9.78 ACE F2 SELP VCAM1
5 blood microparticle GO:0072562 9.76 ALB APOA1 F2 SERPINC1
6 endoplasmic reticulum lumen GO:0005788 9.73 ALB APOA1 APOB F2 IL6 SERPINC1
7 platelet alpha granule lumen GO:0031093 9.55 ALB PPBP SERPINE1 VEGFA VWF
8 extracellular space GO:0005615 9.55 ACE ALB APOA1 APOB CRP F2
9 chylomicron GO:0042627 9.49 APOA1 APOB
10 intermediate-density lipoprotein particle GO:0034363 9.43 APOA1 APOB
11 extracellular exosome GO:0070062 10.1 ACE ALB APOA1 APOB CRP F2

Biological processes related to Peripheral Vascular Disease according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.97 F2 IL6 PPBP SERPINE1 VEGFA
2 inflammatory response GO:0006954 9.97 CRP IL6 PPBP SELE SELP
3 post-translational protein modification GO:0043687 9.91 ALB APOA1 APOB IL6 SERPINC1
4 leukocyte migration GO:0050900 9.83 APOB F2 SELE SELP THBD
5 defense response to Gram-negative bacterium GO:0050829 9.8 IL6 SELP SERPINE1
6 cellular protein metabolic process GO:0044267 9.8 ALB APOA1 APOB F2 IL6 SERPINC1
7 response to nutrient GO:0007584 9.79 APOA1 SERPINC1 VCAM1
8 blood coagulation GO:0007596 9.73 F2 F3 PLAT SERPINC1 THBD VWF
9 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.72 SELE SELP VCAM1
10 acute-phase response GO:0006953 9.67 CRP F2 IL6
11 leukocyte cell-cell adhesion GO:0007159 9.65 SELE SELP VCAM1
12 positive regulation of blood coagulation GO:0030194 9.64 F2 SERPINE1
13 low-density lipoprotein particle remodeling GO:0034374 9.63 APOB LPA
14 positive regulation of positive chemotaxis GO:0050927 9.63 F3 VEGFA
15 fibrinolysis GO:0042730 9.63 F2 PLAT SERPINE1
16 response to lipopolysaccharide GO:0032496 9.63 APOB PPBP SELE SELP THBD VCAM1
17 neutrophil mediated immunity GO:0002446 9.61 ACE IL6
18 chylomicron assembly GO:0034378 9.61 APOA1 APOB
19 negative regulation of lipid storage GO:0010888 9.6 CRP IL6
20 negative regulation of platelet activation GO:0010544 9.59 F2 THBD
21 chylomicron remodeling GO:0034371 9.58 APOA1 APOB
22 leukocyte tethering or rolling GO:0050901 9.58 SELE SELP VCAM1
23 lipoprotein biosynthetic process GO:0042158 9.56 APOA1 APOB
24 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.54 ACE VEGFA
25 negative regulation of fibrinolysis GO:0051918 9.54 F2 SERPINE1 THBD
26 positive regulation of STAT protein import into nucleus GO:2000366 9.52 F2 IL6
27 hemostasis GO:0007599 9.35 F2 F3 SERPINC1 THBD VWF
28 platelet degranulation GO:0002576 9.17 ALB APOA1 PPBP SELP SERPINE1 VEGFA

Molecular functions related to Peripheral Vascular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.67 F2 F3 LPA PLAT
2 phospholipid binding GO:0005543 9.58 APOA1 APOB F3
3 growth factor activity GO:0008083 9.46 F2 IL6 PPBP VEGFA
4 sialic acid binding GO:0033691 9.32 SELE SELP
5 oligosaccharide binding GO:0070492 9.26 SELE SELP
6 protease binding GO:0002020 9.26 F3 SERPINC1 SERPINE1 VWF
7 heparin binding GO:0008201 9.1 APOB F2 LPA SELP SERPINC1 VEGFA

Sources for Peripheral Vascular Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
12