PAD
MCID: PRP027
MIFTS: 71

Peripheral Vascular Disease (PAD) malady

Cardiovascular category

Summaries for Peripheral Vascular Disease

Sources:
34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
See all sources

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MedlinePlus:34 Peripheral arterial disease (pad) happens when there is a narrowing of the blood vessels outside of your heart. the cause of pad is atherosclerosis. this happens when plaque builds up on the walls of the arteries that supply blood to the arms and legs. plaque is a substance made up of fat and cholesterol. it causes the arteries to narrow or become blocked. this can reduce or stop blood flow, usually to the legs. if severe enough, blocked blood flow can cause tissue death and can sometimes lead to amputation of the foot or leg. the main risk factor for pad is smoking. other risk factors include older age and diseases like diabetes, high blood cholesterol, high blood pressure, heart disease, and stroke. many people who have pad don't have any symptoms. if you have symptoms, they may include pain, numbness, achiness, or heaviness in the leg muscles. this happens when walking or climbing stairs. weak or absent pulses in the legs or feet sores or wounds on the toes, feet, or legs that heal slowly, poorly, or not at all a pale or bluish color to the skin a lower temperature in one leg than the other leg poor nail growth on the toes and decreased hair growth on the legs erectile dysfunction, especially among men who have diabetes pad can increase your risk of heart attack, stroke, and transient ischemic attack. doctors diagnose pad with a physical exam and heart and imaging tests. treatments include lifestyle changes, medicines, and sometimes surgery. lifestyle changes include dietary changes, exercise, and efforts to lower high cholesterol levels and high blood pressure. nih: national heart, lung, and blood institute

MalaCards: Peripheral Vascular Disease, also known as peripheral vascular diseases, is related to vascular disease and coronary artery disease,. An important gene associated with Peripheral Vascular Disease is CETP (cholesteryl ester transfer protein, plasma), and among its related pathways are Scavenging by Class B Receptors and LDL-mediated lipid transport. The drugs papaverine and alteplase and the compounds alpha tocopherol and kininogen have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and retina, and related mouse phenotypes are cardiovascular system and liver/biliary system.

CDC:3 Peripheral Arterial Disease (PAD) in the Legs or lower extremities is the narrowing or blockage of the vessels that carry blood from the heart to the legs. It is primarily caused by the buildup of fatty plaque in the arteries, which is called atherosclerosis. PAD can occur in any blood vessel, but it is more common in the legs than the arms.

Wikipedia:64 Peripheral vascular disease (PVD), commonly referred to as peripheral artery disease (PAD) or peripheral... more...

Aliases & Classifications for Peripheral Vascular Disease

Sources:
33MalaCards, 8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 31LifeMap Discovery™, 61UMLS, 35MeSH, 57SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular


Aliases & Descriptions:

peripheral vascular disease 33 8 10 31
peripheral vascular diseases 45 61
arterial occlusive diseases 45 61
peripheral arterial disease 33 34
arterial occlusive disease 33 8
peripheral occlusive disease 33
peripheral arterial diseases 61
pad mass 61
pad 33


External Ids:

Disease Ontology8 DOID:2868, DOID:341
MeSH35 D001157
SNOMED-CT57 2929001, 195624006
ICD9CM27 443.81
ICD1025 I73.8

Related Diseases for Peripheral Vascular Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Peripheral Vascular Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 314)
idRelated DiseaseScoreTop Affiliating Genes
1vascular disease32.0CETP, SELP, SERPINE1, SELE, VCAM1, ACE
2coronary artery disease,31.0CETP, SELP, SERPINE1, SELE, VCAM1, ACE
3stroke, ischemic30.6SELP, SERPINE1, VWF, PF4, LPA, PPBP
4atherosclerosis30.6ALB, CETP, SELP, SERPINE1, SELE, VCAM1
5carotid stenosis30.5SELP
6vasculitis30.4ALB, SELP, SELE, VCAM1, VWF, PPBP
7cadasil30.4CETP, SELP, SERPINE1, ACE, HMGCR, VWF
8coronary heart disease30.4CETP, SELP, SERPINE1, SELE, VCAM1, ACE
9osteoarthritis30.3VCAM1, PPBP
10protein s deficiency30.3SERPINE1
11intermittent claudication30.2SELP, VWF, PF4
12thrombocytopenia30.1ALB, SELP, VWF, PF4, PPBP
13arteriosclerosis obliterans30.0SELP, VCAM1, PF4
14familial hypercholesterolemia30.0CETP, HMGCR, APOB
15hyperlipidemia type 330.0CETP, HMGCR, LPA, APOB, APOA1
16arteriosclerosis30.0SERPINE1, VCAM1, HMGCR, APOB, APOA1
17thrombophilia30.0SELP, SERPINE1, SELE, VWF, PF4, PPBP
18antiphospholipid syndrome30.0SELP, SELE, VCAM1, PLTP, VWF, PF4
19hyperhomocysteinemia30.0ALB, SELP, SERPINE1, SELE, VCAM1, VWF
20venous thrombosis30.0CETP, SELP, SERPINE1, HMGCR, VWF, FGB
21glucose intolerance30.0CETP, SERPINE1, APOB, APOA1
22acute myocardial infarction30.0SELP, SERPINE1, SELE, ACE, HMGCR, VWF
23tangier disease30.0CETP, PLTP, LPA, APOB, APOA2, APOA1
24hypercholesterolemia30.0CETP, SELP, SERPINE1, SELE, VCAM1, ACE
25diabetic nephropathy30.0ALB, SERPINE1, ACE, HMGCR, VWF, LPA
26arthritis29.8ALB, SELE, HMGCR
27asthma29.8CETP, SELE, VCAM1, MS4A2, PPBP
28amyloidosis29.8ALB, LPA, APOA2, APOA1
29insulin resistance29.8ALB, CETP, SERPINE1, SELE, VCAM1, ACE
30lip disease10.6
31spinal cord disease10.5
32aortic disease10.5
33peripheral arterial occlusive disease 110.5
34nutrition disease10.4
35keratoderma10.4
36vascular skin disease10.4
37vein disease10.4
38abdominal aortic aneurysm10.3
39aneurysm disease10.3
40aortic aneurysm10.3
41devic disease10.3
42autosomal dominant disease10.3
43bart-pumphrey syndrome10.3
44oral submucous fibrosis10.3
45palmoplantar keratoderma, epidermolytic10.3
46protein c deficiency10.3
47angina pectoris10.3
48cardiovascular disease risk factor10.3
49critical limb ischemia10.3
50synovitis10.2

Graphical network of the top 20 diseases related to Peripheral Vascular Disease:



Diseases related to peripheral vascular disease

Clinical Features for Peripheral Vascular Disease

Drugs & Therapeutics for Peripheral Vascular Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Peripheral Vascular Disease

Drug clinical trials:

Search ClinicalTrials for Peripheral Vascular Disease

Search NIH Clinical Center for Peripheral Vascular Disease

Search CenterWatch for Peripheral Vascular Disease

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Peripheral Vascular Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Peripheral Vascular Disease:
ALD-301, bone marrow-derived cells for critical limb ischemia
Alecmestencel-T, mesenchymal stem cells for ischemic diseases
ALO212, umbilical cord blood-derived stem cell concentrate for vascular diseases
Autologus endothelial progenitor cells for the treatment of critical limb ischemia
Autologus hematopoeitic stem cells for the treatment of critical limb ischemia
Bone marrow-derived CD133+ or nucleated cells for peripheral artery disease
Bone marrow-derived mononuclear cells for peripheral vascular disease
Bone marrow-derived mononuclear stem cells for treatment of critical limb ischemia
Endothelial progenitor cells for peripheral artery disease
Enriched bone marrow-derived progenitor cells for ischemic diseases
MultiStem
Peripheral blood-derived hematopoietic stem cells for leg gangrene
TGI PVG, adipose-derived stem cell-coated vascular graft for peripheral vascular disease
Embryonic/Adult Cultured Cells Related to Peripheral Vascular Disease:
Bone marrow-derived CD133+ stem cells
Bone marrow-derived ALDH+ cells (ALD), PMIDs: 10430905, 19324906
Bone marrow-derived mesenchymal stem cells (family)
Cord blood-derived hematopoietic stem cell, PMID: 19558779
Peripheral blood-derived endothelial cells, PMIDs: 19448678, 18388019
Peripheral blood-derived hematopoietic stem cells, PMID: 18388019
Bone marrow-derived mononuclear cells (family)
Bone marrow-derived mononuclear cells
Bone marrow-derived mononuclear cells
Peripheral blood-derived endothelial progenitor cells, PMID: 10725398
Bone marrow-derived progenitor cells
Bone marrow-derived adherent progenitor cells (MultiStem), PMID: 23307829
Peripheral blood-derived hematopoietic stem cells
Adipose-derived stromal cells, PMIDs: 8207032, 23350681

Genetic Tests for Peripheral Vascular Disease

Anatomical Context for Peripheral Vascular Disease

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Peripheral Vascular Disease:

33
Bone marrow, Brain, Retina, Spinal cord, Heart, Smooth muscle, Skeletal muscle, Kidney, Lung, Pancreas, Skin, Myeloid, Monocytes, T cells, Endothelial

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Peripheral Vascular Disease:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Peripheral Vascular Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Peripheral Vascular Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053859.9APOA1, APOB, ACE, VCAM1, SELE, SELP
2MP:00053709.5SELP, ALB, SERPINE1, SELE, ACE, APOB
3MP:00053769.1PLTP, APOA2, APOB, PF4, VWF, ACE

Publications for Peripheral Vascular Disease

Sources:
51PubMed
See all sources

Articles related to Peripheral Vascular Disease:

(show top 50)    (show all 572)
idTitleAuthorsYear
1
Effect of peripheral vascular disease on kidney allograft outcomes: a study of U.S. Renal data system. (23354295)
2013
2
Radiotracer imaging of peripheral vascular disease. (24101686)
2013
3
Associations of candidate biomarkers of vascular disease with the ankle-brachial index and peripheral arterial disease. (23467205)
2013
4
peripheral neuropathy associated to cerebro-vascular disease revealing a systemic sclerodermy. (24343496)
2013
5
Cilostazol prevents foot ulcers in diabetic patients withA peripheral vascular disease. (23672237)
2013
6
Vascular disease: Peripheral artery disease pandemic. (23959226)
2013
7
Higher serum levels of soluble intracellular cell adhesion molecule-1 and soluble vascular cell adhesion molecule predict peripheral artery disease in haemodialysis patients. (22905988)
2012
8
Assessment of peripheral vascular disease in patients with chronic kidney disease. (23146975)
2012
9
Blood pressure variability and cardiovascular autonomic control during hemodialysis in peripheral vascular disease patients. (22442189)
2012
10
Compartment syndrome as a rare complication of iloprost infusion for peripheral vascular disease. (21549925)
2011
11
MoxyAr drug-coated balloon: a novel device for the treatment of coronary and peripheral vascular disease. (21646072)
2011
12
A further word of caution before using the internal mammary artery for coronary revascularization in patients with severe peripheral vascular disease! (19937782)
2010
13
Spinal cord stimulation for the treatment of angina and peripheral vascular disease. (19126366)
2009
14
Obliteration Index: a simple non-invasive tool for the assessment of peripheral vascular disease in chronic kidney disease. (19662610)
2009
15
The treatment of peripheral vascular disease: scio me nihil scire. (19494405)
2009
16
Atherosclerotic Peripheral Vascular Disease Symposium II: stroke intervention: state of the art. (19106406)
2008
17
Impaired flow-mediated endothelium-dependent and endothelium-independent vasodilation of the brachial artery in patients with atherosclerotic peripheral vascular disease. (18319222)
2008
18
Intravascular brachytherapy for peripheral vascular disease. (21289914)
2008
19
Metabolic syndrome and incident end-stage peripheral vascular disease: a 14-year follow-up study in elderly Finns. (17848614)
2007
20
No effect of homocysteine-lowering therapy on vascular inflammation and haemostasis in peripheral arterial occlusive disease. (16634837)
2006
21
Peripheral vascular disease and outcomes following coronary artery bypass graft surgery. (17178964)
2006
22
Evidence-based management of peripheral vascular disease. (16105478)
2005
23
C-reactive protein and risk factors for peripheral vascular disease in subjects with Type 2 diabetes mellitus. (15049935)
2004
24
Implementation of an iron reduction protocol in patients with peripheral vascular disease: VA cooperative study no. 410: the Iron (Fe) and Atherosclerosis Study (FeAST). (15389223)
2004
25
Bivalirudin as a foundation anticoagulant in peripheral vascular disease: a safe and feasible alternative for renal and iliac interventions. (12777673)
2003
26
Multidetector CT angiography of peripheral vascular disease: a prospective comparison with intraarterial digital subtraction angiography. (12591682)
2003
27
From the RSNA refresher courses: MR imaging of aortic and peripheral vascular disease. (14557503)
2003
28
A human model of platelet-leucocyte adhesive interactions during controlled ischaemia in patients with peripheral vascular disease. (12461065)
2002
29
Impaired carotid and femoral viscoelastic properties and elevated intima-media thickness in peripheral vascular disease. (12119200)
2002
30
Antithrombotic therapy in peripheral vascular disease. (12424175)
2002
31
Is duplex ultrasonography an effective single modality for the preoperative evaluation of peripheral vascular disease? (12516819)
2002
32
Ethnicity and peripheral vascular disease. (12469976)
2002
33
Alterations of thrombogenesis, endothelial damage and oxidative stress with reperfusion during femoral artery bypass surgery for peripheral vascular disease. (12759516)
2002
34
Peripheral vascular disease intervention in patients with end-stage renal disease: few complications in those treated with peritoneal dialysis. (11702811)
2001
35
Incidental renal artery stenosis in peripheral vascular disease: a case for treatment? (11260411)
2001
36
Legs For Life national screening program for peripheral vascular disease: addressing a major public health need. (11287507)
2001
37
Sympathetic autoregulation in peripheral vascular disease. (11298619)
2001
38
Elevated levels of soluble E-selectin in diabetic patients with severe symptomatic peripheral arterial occlusive disease requiring angioplasty. A possible role in diabetic vascular disease? (10905802)
2000
39
Can the green laser doppler measure skin-nutritive perfusion in patients with peripheral vascular disease? (10859478)
2000
40
Prostaglandin E1-therapy reduces circulating adhesion molecules (ICAM-1, E-selectin, VCAM-1) in peripheral vascular disease. (11037715)
2000
41
The effect of short-term lipid lowering with atorvastatin on carotid artery intima media thickness in patients with peripheral vascular disease: a pilot study. (11191010)
2000
42
Asymptomatic carotid artery stenosis associated with peripheral vascular disease: a prospective study. (10073759)
1999
43
Deep venous thrombosis in peripheral vascular disease. (10417563)
1999
44
Peripheral vascular disease in pancreas allograft recipients. (10371986)
1999
45
Application of near-infrared tissue oxymetry to the diagnosis of peripheral vascular disease. (10711775)
1999
46
Screening for asymptomatic carotid stenosis in patients with peripheral vascular disease: a prospective study and risk factor analysis. (10386747)
1999
47
Vascular endothelial growth factor (VEGF) in Crohn's disease: increased production by peripheral blood mononuclear cells and decreased VEGF165 labeling of peripheral CD14+ monocytes. (10389696)
1999
48
Diabetes and peripheral vascular disease. (10436463)
1999
49
Premature peripheral vascular disease: clinical profile and abnormal lipid peroxidation. (9610833)
1998
50
Haemostatic system activation and prediction of vascular events in patients presenting with stable peripheral arterial disease of moderate severity. Royat Study Group. (9622210)
1998

Genetic Variations for Peripheral Vascular Disease

Expression for genes affiliated with Peripheral Vascular Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Peripheral Vascular Disease

Search GEO for disease gene expression data for Peripheral Vascular Disease.

Pathways for genes affiliated with Peripheral Vascular Disease

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 12EMD Millipore, 53R&D Systems, 50PharmGKB
See all sources

Pathways related to Peripheral Vascular Disease according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3APOA1, APOB
210.2CETP, LPA, APOB
310.2SELP, LPA, APOB
410.2SELE, VCAM1, APOA1
510.2SELP, SELE, APOB
610.2ALB, CETP, APOB
710.2APOB, VWF, CETP
8
Hide members
10.2APOA1, APOB, ALB
9
Hide members
10.2APOB, APOA2, APOA1
10
Hide members
10.1FGB, VWF, SERPINE1
1110.1PLTP, APOA2, APOA1
1210.1APOA1, APOB, SERPINE1, ALB
13
Hide members
10.1SERPINE1, VCAM1, VWF, FGB
14
Hide members
10.0APOA2, FGB, VWF, SERPINE1
1510.0APOA1, APOA2, APOB, LPA, ALB
16
Hide members
9.9APOA1, APOA2, APOB, LPA, CETP, ALB
17
Hide members
9.9FGB, VWF, SELE, SERPINE1, SELP, ALB
18
Hide members
9.9APOA1, APOA2, APOB, PLTP, HMGCR, CETP
19
Hide members
9.6ALB, APOA1, PPBP, PF4, FGB, VWF
20
Hide members
9.5APOA1, APOA2, APOB, PPBP, PF4, FGB

Compounds for genes affiliated with Peripheral Vascular Disease

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Peripheral Vascular Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 230)
idCompoundScoreTop Affiliating Genes
1alpha tocopherol4510.7PLTP
2kininogen4510.5SERPINE1, ACE, VWF, APOB
3dextran sulfate4510.4APOA1, APOB, PLTP, SELP, CETP
4sele4510.4ACE, CETP, SELE, SELP, VCAM1
5quinapril45 1111.3SERPINE1, SELE, ACE, SELP, VWF
6vitamin a45 11 2412.3CETP, LPA, APOB, APOA1
7acipimox45 2911.3APOB, HMGCR, APOA1, CETP, PLTP
8gemfibrozil45 29 1112.3SERPINE1, LPA, APOA1, APOB, APOA2, CETP
9iohexol4510.3APOA1, PPBP, ALB, SELP, PF4
10serine4510.3CETP, SELE, APOA2, HMGCR, KLK15
1111-dehydrothromboxane b24510.3SELP, SERPINE1, VWF, PF4, PPBP
12warfarin45 50 11 2413.3PF4, PPBP, VWF, HMGCR, SELP, LPA
13probucol45 1111.2SELE, VCAM1, HMGCR, PLTP, APOB, APOA1
14phosphatidylcholine4510.2LPA, APOA2, APOA1, APOB, CETP, PLTP
15amlodipine45 50 11 2413.2HMGCR, ALB, SERPINE1, VCAM1, ACE
16ticlopidine45 1111.2VWF, PF4, PPBP, SELP, HMGCR
17polysulfone4510.2PF4, SELP, PPBP, VWF, ALB, VCAM1
18bezafibrate45 29 1112.2SERPINE1, HMGCR, LPA, APOB, APOA2, APOA1
19hirudin4510.2SELP, VWF, SELE, SERPINE1, FGB, PF4
20losartan45 50 29 1113.2SELE, SERPINE1, VWF, SELP, ALB, ACE
21cholesterol ester4510.2HMGCR, CETP, APOA1, APOA2, APOB, LPA
22rosuvastatin45 50 29 1113.2APOB, HMGCR, CETP, APOA1, ALB
23triacylglycerol4510.1APOB, APOA2, PLTP, SERPINE1, CETP, APOA1
24thyroxine45 2411.1ALB, CETP, HMGCR, VWF, LPA, APOB
25clopidogrel50 45 11 2413.1SELP, PPBP, VWF, HMGCR, ACE
26fenofibric acid45 2911.1HMGCR, APOB, APOA1, SERPINE1
27pravastatin45 50 29 11 2414.1APOA1, APOB, LPA, HMGCR, VCAM1, SELE
28mspi4510.1APOA2, APOB, CETP, APOA1, LPA
29iloprost45 60 29 1113.1PPBP, PF4, SELE, VCAM1, SELP
30fluvastatin45 50 29 1113.1CETP, SELP, SERPINE1, SELE, VCAM1, HMGCR
31glucose4510.0APOA1, PLTP, PPBP, LPA, PF4, RARRES2
32atorvastatin45 50 29 11 2414.0CETP, SELP, SERPINE1, SELE, VCAM1, HMGCR
33homocysteine45 2411.0APOA1, APOB, LPA, VWF, VCAM1, SELE
34heparin45 29 11 2413.0APOA2, PPBP, LPA, HMGCR, VCAM1, SELE
35lovastatin45 50 60 29 1113.9SERPINE1, LPA, HMGCR, CETP, APOB, APOA1
36prostacyclin459.9VWF, HMGCR, ACE, VCAM1, SELE, SERPINE1
37histamine45 29 2411.9ALB, SELP, SELE, PF4, HMGCR, VCAM1
38simvastatin45 50 60 29 11 2414.9PLTP, VCAM1, HMGCR, SELE, SERPINE1, CETP
39fenofibrate45 50 1111.9CETP, SELP, SERPINE1, APOA1, APOA2, APOB
40lactate459.8APOA1, APOB, PPBP, PF4, ALB, VWF
41niacin45 1110.7CETP, HMGCR, LPA, APOB, APOA1
42aspirin45 50 29 2412.7PPBP, LPA, PF4, VWF, HMGCR, ACE
43vegf459.7SERPINE1, SELP, SELE, VCAM1, HMGCR, VWF
44creatinine459.7HMGCR, ACE, SELE, SERPINE1, SELP, ALB
45alanine459.7APOA1, APOB, PPBP, PF4, ALB, VWF
46cysteine459.6VCAM1, HMGCR, PPBP, RARRES2, VWF, PF4
47fibrinogen459.6FGB, VWF, VCAM1, SELE, SERPINE1, ALB
48testosterone45 60 11 2412.5SELE, KLK15, APOA1, ALB, CETP, SERPINE1
49lipid459.4PLTP, PF4, PPBP, APOB, APOA1, LPA
50cholesterol45 29 11 2412.3APOA1, APOA2, APOB, PPBP, LPA, PF4

GO Terms for genes affiliated with Peripheral Vascular Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Peripheral Vascular Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1very-low-density lipoprotein particleGO:03436110.3APOB, APOA2, APOA1
2chylomicronGO:04262710.3APOB, APOA2
3high-density lipoprotein particleGO:03436410.3APOA1, APOA2, CETP
4spherical high-density lipoprotein particleGO:03436610.2APOA1, APOA2
5early endosomeGO:00576910.1VCAM1, APOB, APOA2, APOA1
6external side of plasma membraneGO:00989710.0FGB, VWF, ACE, MS4A2, VCAM1, SELP
7platelet alpha granule lumenGO:03109310.0PPBP, PF4, FGB, VWF, SERPINE1, ALB
8platelet alpha granuleGO:0310919.9VWF, FGB
9extracellular spaceGO:0056159.5APOA1, APOB, PPBP, PF4, FGB, ACE
10extracellular regionGO:0055769.1ALB, KLK15, APOA1, APOA2, APOB, PPBP

Biological processes related to Peripheral Vascular Disease according to GeneCards/GeneDecks:

(show all 34)
idNameGO IDScoreTop Affiliating Genes
1leukocyte tethering or rollingGO:05090110.6VCAM1, SELE, SELP
2lipoprotein biosynthetic processGO:04215810.6APOA1, APOB
3negative regulation of lipase activityGO:06019210.6APOA1, APOA2
4negative regulation of very-low-density lipoprotein particle remodelingGO:01090310.6APOA1, APOA2
5cholesterol transportGO:03030110.6APOA1, APOB, CETP
6regulation of intestinal cholesterol absorptionGO:03030010.6APOA2, APOA1
7low-density lipoprotein particle remodelingGO:03437410.6APOA2, APOB, CETP
8leukocyte cell-cell adhesionGO:00715910.6SELP, SELE, VCAM1
9heterophilic cell-cell adhesionGO:00715710.5SELP, SELE, VCAM1
10high-density lipoprotein particle remodelingGO:03437510.5APOA1, APOA2, CETP
11high-density lipoprotein particle assemblyGO:03438010.5APOA1, APOA2
12reverse cholesterol transportGO:04369110.5CETP, APOA2, APOA1
13protein oxidationGO:01815810.5APOA1, APOA2
14negative regulation of cytokine secretion involved in immune responseGO:00274010.5APOA1, APOA2
15cholesterol effluxGO:03334410.5APOA1, APOA2, APOB
16retinoid metabolic processGO:00152310.5APOA2, APOB, RARRES2
17negative regulation of wound healingGO:06104510.5HMGCR, SERPINE1
18cholesterol homeostasisGO:04263210.5APOA1, APOA2, APOB, CETP
19response to nutrientGO:00758410.5APOA1, HMGCR, VCAM1, ALB
20receptor-mediated endocytosisGO:00689810.5APOB, LPA, CETP
21cholesterol metabolic processGO:00820310.5CETP, APOB, APOA2, APOA1
22high-density lipoprotein particle clearanceGO:03438410.4APOA1, APOA2
23lipid transportGO:00686910.4LPA, PLTP, CETP
24peptidyl-methionine modificationGO:01820610.4APOA1, APOA2
25phospholipid homeostasisGO:05509110.4APOA1, CETP
26positive regulation of cholesterol esterificationGO:01087310.4APOA2, APOA1
27lipoprotein metabolic processGO:04215710.3APOA1, APOA2, APOB, LPA, CETP, ALB
28phototransduction, visible lightGO:00760310.2APOB, APOA2, APOA1
29phospholipid effluxGO:03370010.2APOA1, APOA2
30platelet degranulationGO:00257610.0ALB, APOA1, PPBP, PF4, FGB, VWF
31positive regulation of leukocyte migrationGO:00268710.0SELE, SELP
32platelet activationGO:03016810.0APOA1, PPBP, PF4, FGB, VWF, SERPINE1
33blood coagulationGO:0075969.8APOA1, APOB, PPBP, PF4, FGB, VWF
34small molecule metabolic processGO:0442819.8APOA1, APOA2, APOB, LPA, HMGCR, CETP

Molecular functions related to Peripheral Vascular Disease according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1oligosaccharide bindingGO:07049210.5SELE, SELP
2high-density lipoprotein particle receptor bindingGO:07065310.5APOA1, APOA2
3apolipoprotein receptor bindingGO:03419010.4APOA1, APOA2
4cholesterol bindingGO:01548510.4CETP, APOA2, APOA1
5phosphatidylcholine-sterol O-acyltransferase activator activityGO:06022810.4APOA1, APOA2
6cholesterol transporter activityGO:01712710.4CETP, APOB, APOA2, APOA1
7lipase inhibitor activityGO:05510210.3APOA1, APOA2
8heparin bindingGO:00820110.3APOB, LPA, PF4, SELP
9phospholipid transporter activityGO:00554810.3CETP, APOA1
10chaperone bindingGO:05108710.3ALB, VWF, FGB
11phosphatidylcholine bindingGO:03121010.3CETP, APOA2
12high-density lipoprotein particle bindingGO:00803510.2APOA1, APOA2
13sialic acid bindingGO:03369110.0SELP, SELE

Products for genes affiliated with Peripheral Vascular Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Peripheral Vascular Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet