PAD
MCID: PRP027
MIFTS: 75

Peripheral Vascular Disease (PAD) malady

Cardiovascular diseases category

Summaries for Peripheral Vascular Disease

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33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Peripheral arterial disease (pad) happens when there is a narrowing of the blood vessels outside of your heart. the cause of pad is atherosclerosis. this happens when plaque builds up on the walls of the arteries that supply blood to the arms and legs. plaque is a substance made up of fat and cholesterol. it causes the arteries to narrow or become blocked. this can reduce or stop blood flow, usually to the legs. if severe enough, blocked blood flow can cause tissue death and can sometimes lead to amputation of the foot or leg. the main risk factor for pad is smoking. other risk factors include older age and diseases like diabetes, high blood cholesterol, high blood pressure, heart disease, and stroke. many people who have pad don't have any symptoms. if you have symptoms, they may include pain, numbness, achiness, or heaviness in the leg muscles. this happens when walking or climbing stairs. weak or absent pulses in the legs or feet sores or wounds on the toes, feet, or legs that heal slowly, poorly, or not at all a pale or bluish color to the skin a lower temperature in one leg than the other leg poor nail growth on the toes and decreased hair growth on the legs erectile dysfunction, especially among men who have diabetes pad can increase your risk of heart attack, stroke, and transient ischemic attack. doctors diagnose pad with a physical exam and heart and imaging tests. treatments include lifestyle changes, medicines, and sometimes surgery. lifestyle changes include dietary changes, exercise, and efforts to lower high cholesterol levels and high blood pressure. nih: national heart, lung, and blood institute

MalaCards: Peripheral Vascular Disease, also known as peripheral vascular diseases, is related to vascular disease and renal vascular disease. An important gene associated with Peripheral Vascular Disease is CETP (cholesteryl ester transfer protein, plasma), and among its related pathways are Scavenging by Class B Receptors and LDL-mediated lipid transport. The drugs papaverine and alteplase and the compounds alpha tocopherol and kininogen have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and endothelial, and related mouse phenotypes are cardiovascular system and liver/biliary system.

CDC:3 Peripheral Arterial Disease (PAD) in the Legsor lower extremities is the narrowing or blockage of the vessels that carry blood from the heart to the legs. It is primarily caused by the buildup of fatty plaque in the arteries, which is called atherosclerosis. PAD can occur in any blood vessel, but it is more common in the legs than the arms.

Wikipedia:63 Peripheral vascular disease (PVD), commonly referred to as peripheral artery disease (PAD) or peripheral... more...

Aliases & Classifications for Peripheral Vascular Disease

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Sources:
32MalaCards, 8Disease Ontology, 10DISEASES, 30LifeMap Discovery™, 33MedlinePlus, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

peripheral vascular disease 32 8 10 30
peripheral vascular diseases 44 60
arterial occlusive diseases 44 60
peripheral arterial disease 32 33
arterial occlusive disease 32 8
peripheral occlusive disease 32
peripheral arterial diseases 60
pad mass 60
pad 32


External Ids:

Disease Ontology8 DOID:2868, DOID:341
MeSH34 D001157
SNOMED-CT56 2929001, 195624006
ICD9CM27 443.81
ICD1025 I73.8

Related Diseases for Peripheral Vascular Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Peripheral Vascular Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 340)
idRelated DiseaseScoreTop Affiliating Genes
1vascular disease32.0CETP, SELP, SERPINE1, SELE, VCAM1, ACE
2renal vascular disease30.9ALB, ACE
3coronary artery disease30.9CETP, SELP, SERPINE1, SELE, VCAM1, ACE
4diabetes mellitus30.8ALB, CETP, SELP, SERPINE1, SELE, VCAM1
5hypertension30.6ALB, SERPINE1, SELE, VCAM1, ACE, LPA
6ischemic heart disease30.6CETP, SELP, SERPINE1, ACE, HMGCR, PF4
7stroke, ischemic30.6ALB, SERPINE1, SELE, VCAM1, ACE, HMGCR
8atherosclerosis30.6ALB, CETP, SELP, SERPINE1, SELE, VCAM1
9skin disease30.5ALB
10type 2 diabetes mellitus30.5ALB, CETP, SELP, SERPINE1, SELE, VCAM1
11carotid stenosis30.5SELP
12neuropathy30.5ALB
13dermatitis30.4SELE, VCAM1, MS4A2, PF4
14peritonitis30.4ALB, SELP
15ischemia30.4SELP, SELE, HMGCR, PF4
16vasculitis30.4ALB, SELP, SELE, VCAM1, VWF, PPBP
17cadasil30.4CETP, SELP, SERPINE1, ACE, HMGCR, VWF
18myocardial infarction30.4CETP, SELP, SERPINE1, ACE, HMGCR, VWF
19retinal disease30.4ALB, CETP, SERPINE1, VCAM1, ACE, VWF
20intermittent claudication30.3SELP, VWF, PF4
21obesity30.3CETP, SERPINE1, SELE, RARRES2, PLTP, LPA
22osteoarthritis30.3VCAM1, PPBP
23protein s deficiency30.2SERPINE1
24leukemia30.2PF4, PPBP
25congestive heart failure30.2ACE, HMGCR, PPBP
26cerebrovascular disease30.2CETP, SELP, ACE, HMGCR, APOB, APOA1
27coronary stenosis30.2CETP, SELP, LPA, APOB, APOA1
28crohn's disease30.0ALB
29thrombocytopenia30.0ALB, SELP, VWF, PF4, PPBP
30breast cancer30.0ALB, SERPINE1, PPBP, KLK15
31pancreatitis30.0ALB, SELP
32arteriosclerosis obliterans30.0SELP, VCAM1, PF4
33familial hypercholesterolemia30.0CETP, HMGCR, APOB
34lung cancer30.0ALB
35hyperlipidemia type 330.0CETP, HMGCR, LPA, APOB, APOA1
36arteriosclerosis30.0SERPINE1, VCAM1, HMGCR, APOB, APOA1
37melanoma30.0VCAM1, HMGCR, PF4, PPBP
38thrombophilia30.0SELP, SERPINE1, SELE, VWF, PF4, PPBP
39antiphospholipid syndrome30.0SELP, SELE, VCAM1, PLTP, VWF, PF4
40hyperhomocysteinemia30.0ALB, SELP, SERPINE1, SELE, VCAM1, VWF
41glucose intolerance30.0CETP, SERPINE1, APOB, APOA1
42diabetic nephropathy30.0ALB, SERPINE1, ACE, HMGCR, VWF, LPA
43proteinuria30.0ALB, CETP, ACE, HMGCR, PF4, LPA
44tangier disease29.9CETP, PLTP, LPA, APOB, APOA2, APOA1
45hyperparathyroidism29.9ALB
46hyperglycemia29.9ALB, CETP, SERPINE1, SELE, VCAM1, ACE
47acute myocardial infarction29.9SELP, SERPINE1, SELE, ACE, HMGCR, VWF
48prostate cancer29.7KLK15
49lipodystrophy29.7HMGCR, APOB
50arthritis29.7ALB, SELE, HMGCR

Graphical network of the top 20 diseases related to Peripheral Vascular Disease:



Diseases related to peripheral vascular disease

Clinical Features for Peripheral Vascular Disease

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Drugs & Therapeutics for Peripheral Vascular Disease

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Peripheral Vascular Disease

Drug clinical trials:

Search ClinicalTrials for Peripheral Vascular Disease

Search NIH Clinical Center for Peripheral Vascular Disease

Search CenterWatch for Peripheral Vascular Disease

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Peripheral Vascular Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Peripheral Vascular Disease:
ACY001, bone marrow-derived hematopoietic stem cells for coronary artery occlusions
ALD-301, bone marrow-derived cells for critical limb ischemia
ALD-301, bone marrow-derived cells for critical limb ischemia
Alecmestencel-T, mesenchymal stem cells for ischemic diseases
ALO212, umbilical cord blood-derived stem cell concentrate for vascular diseases
Autologus endothelial progenitor cells for the treatment of critical limb ischemia
Autologus hematopoeitic stem cells for the treatment of critical limb ischemia
Bone marrow-derived CD133+ or nucleated cells for peripheral artery disease
Bone marrow-derived mononuclear cells for peripheral vascular disease
Bone marrow-derived mononuclear stem cells for treatment of critical limb ischemia
Endothelial progenitor cells for peripheral artery disease
Enriched bone marrow-derived progenitor cells for ischemic diseases
MultiStem
Peripheral blood-derived hematopoietic stem cells for leg gangrene
TGI PVG, adipose-derived stem cell-coated vascular graft for peripheral vascular disease
Embryonic/Adult Cultured Cells Related to Peripheral Vascular Disease:
Bone marrow-derived CD133+ stem cells
Bone marrow-derived ALDH+ cells (ALD), PMIDs: 10430905, 19324906
Bone marrow-derived ALDH+ cells (ALD), PMIDs: 10430905, 19324906
Bone marrow-derived mesenchymal stem cells (family)
Cord blood-derived hematopoietic stem cell, PMID: 19558779
Peripheral blood-derived endothelial cells, PMIDs: 19448678, 18388019
Peripheral blood-derived hematopoietic stem cells, PMID: 18388019
Bone marrow-derived mononuclear cells (family)
Bone marrow-derived mononuclear cells
Bone marrow-derived mononuclear cells
Peripheral blood-derived endothelial progenitor cells, PMID: 10725398
Bone marrow-derived progenitor cells
Bone marrow-derived adherent progenitor cells (MultiStem), PMID: 23307829
Peripheral blood-derived hematopoietic stem cells
Adipose-derived stromal cells, PMIDs: 8207032, 23350681

Genetic Tests for Peripheral Vascular Disease

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Anatomical Context for Peripheral Vascular Disease

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Sources:
30LifeMap Discovery™, 32MalaCards
See all sources

MalaCards organs/tissues related to Peripheral Vascular Disease:

32
Bone, Heart, Endothelial, Skin, Testes, Brain, Lung, Spinal cord, Kidney, Bone marrow, Pancreas, Monocytes, Skeletal muscle, Smooth muscle, Retina, Myeloid

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Peripheral Vascular Disease:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Peripheral Vascular Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Peripheral Vascular Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053859.9SELP, SELE, VCAM1, ACE, APOB, APOA1
2MP:00053709.5APOA1, APOB, ACE, SELE, SERPINE1, SELP
3MP:00053769.1ALB, APOA1, APOA2, APOB, PF4, VWF

Publications for Peripheral Vascular Disease

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Sources:
50PubMed
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Articles related to Peripheral Vascular Disease:

(show top 50)    (show all 569)
idTitleAuthorsYear
1
Blunted temporal activity of microvascular perfusion heterogeneity in metabolic syndrome: a new attractor for peripheral vascular disease? (23262133)
2013
2
Circulation editors' picks: peripheral vascular disease. (24344067)
2013
3
Combined high thoracic and lumbar epidural block for a patient with severe peripheral vascular disease undergoing axillo bifemoral bypass surgery. (23439952)
2012
4
Vascular disease: now official: smoking promotes peripheral artery disease in women. (21709704)
2011
5
Anabolic androgenic steroid-induced cardiomyopathy, stroke and peripheral vascular disease. (22693308)
2011
6
Foot care for patients with peripheral vascular disease: a review of the guidelines. (22977408)
2010
7
After acute coronary syndrome, diabetic patients with peripheral vascular disease remain at high risk of cardiovascular events despite secondary prevention measures. (20226429)
2010
8
Indications for the performance of intracranial endovascular neurointerventional procedures: a scientific statement from the American Heart Association Council on Cardiovascular Radiology and Intervention, Stroke Council, Council on Cardiovascular Surgery and Anesthesia, Interdisciplinary Council on Peripheral Vascular Disease, and Interdisciplinary Council on Quality of Care and Outcomes Research. (19349327)
2009
9
Total knee arthroplasty in patients with peripheral vascular disease. (20681380)
2009
10
Anti-chlamydial antibiotic therapy for symptom improvement in peripheral artery disease: prospective evaluation of rifalazil effect on vascular symptoms of intermittent claudication and other endpoints in Chlamydia pneumoniae seropositive patients (PROVIDENCE-1). (19139383)
2009
11
Diabetes and peripheral vascular disease. (19994800)
2009
12
Markers of Chlamydia pneumoniae and human cytomegalovirus infection in patients with chronic peripheral vascular disease and their relation to inflammation, endothelial dysfunction and changes in lipid metabolism. (19381484)
2008
13
Protective effects of serum bilirubin on peripheral vascular disease. (18376376)
2008
14
Local paclitaxel delivery in peripheral vascular disease. (18509128)
2008
15
ACE gene polymorphism in peripheral vascular disease. (17611909)
2007
16
Cholesterol and peripheral vascular disease: a neglected topic? (17487760)
2007
17
A safety and feasibility report of combined direct thrombin and GP IIb/IIIa inhibition with bivalirudin and tirofiban in peripheral vascular disease intervention: treating critical limb ischemia like acute coronary syndrome. (16079449)
2005
18
Pharmacotherapeutical approaches to decreasing hematocrit and increasing claudication distance in diabetic patients with peripheral vascular disease. (16601768)
2005
19
Correlation between ankle-brachial index, symptoms, and health-related quality of life in patients with peripheral vascular disease. (15071432)
2004
20
Post-occlusive reactive hyperemia in patients with peripheral vascular disease. (15272149)
2004
21
Effects of R-102444, an orally active 5-HT2A receptor antagonist, in rat models of peripheral vascular disease. (15135326)
2004
22
Ultrasound guidance for difficult lateral popliteal catheter insertion in a patient with peripheral vascular disease. (15305259)
2004
23
Effects of lifestyle modification and lipid intake variations on patients with peripheral vascular disease. (14639803)
2003
24
Pulse pressure as a risk factor for peripheral vascular disease in type 2 diabetic patients. (14649305)
2003
25
Screening by trained nurses for peripheral vascular disease in continuous ambulatory peritoneal dialysis patients with and without diabetes. (17986533)
2003
26
Percutaneous arterial closure in peripheral vascular disease: a prospective randomized evaluation of the Perclose device. (12891107)
2003
27
Enhancing foot skin blood flux in peripheral vascular disease using intermittent pneumatic compression: controlled study on claudicants and grafted arteriopaths. (12096335)
2002
28
Contrast-enhanced magnetic resonance angiography MoBI-trak in the study of peripheral vascular disease. (11907773)
2002
29
Lack of association between angiotensin-converting enzyme gene polymorphism and peripheral vascular disease in type 2 diabetic patients in Taiwan. (12419932)
2002
30
Endovascular workforce for peripheral vascular disease: current and future needs. (12042734)
2002
31
The Legs For Life Screening for Peripheral Vascular Disease: results of a prospective study designed to improve patient compliance with physician recommendations. (11585880)
2001
32
Parameters of postocclusive reactive hyperemia measured by near infrared spectroscopy in patients with peripheral vascular disease and in healthy volunteers. (11339328)
2001
33
Coagulation, fibrinolysis and platelet P-selectin expression in peripheral vascular disease. (11237788)
2001
34
Optimized diagnostic angiography in high-risk patients with severe peripheral vascular disease. (10682777)
2000
35
Arterial pulse wave velocity and risk factors for peripheral vascular disease. (10879436)
2000
36
Spontaneous arteriovenous fistulas of the lower extremities: angiographic demonstration in five patients with peripheral vascular disease. (10960551)
2000
37
Noninvasive vascular laboratory for evaluation of peripheral arterial occlusive disease: Part II--clinical applications: chronic, usually atherosclerotic, lower extremity ischemia. (11099236)
2000
38
Low rates of preventive practices in patients with peripheral vascular disease. (10579741)
1999
39
Magnetic resonance angiography of peripheral vascular disease. (10608408)
1999
40
Quantitative study of capillary density in the skin of the foot in peripheral vascular disease. (10201776)
1999
41
Is clopidogrel markedly superior to aspirin in patients with peripheral vascular disease? (16793749)
1998
42
Medical outcomes studies in peripheral vascular disease. (9840031)
1998
43
Control of risk factors in peripheral vascular disease. Management of hypertension. (9673651)
1998
44
Lipid levels and peripheral vascular disease in diabetic and non-diabetic subjects. (9544725)
1998
45
Pain and powerlessness: the experience of living with peripheral vascular disease. (9578203)
1998
46
Effect of cilostazol on walking distances in patients with intermittent claudication caused by peripheral vascular disease. (9510281)
1998
47
Plasma concentration of C-reactive protein and risk of developing peripheral vascular disease. (9490235)
1998
48
Effect of felodipine on regional blood supply and collateral vascular resistance in patients with peripheral arterial occlusive disease. (9546944)
1997
49
Intensive vascular training in stage IIb of peripheral arterial occlusive disease. The additive effects of intravenous prostaglandin E1 or intravenous pentoxifylline during training. (8044953)
1994
50
Beneficial effects of a serine protease inhibitor in peripheral vascular disease. (8328387)
1993

Genetic Variations for Peripheral Vascular Disease

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Expression for genes affiliated with Peripheral Vascular Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Peripheral Vascular Disease

Search GEO for disease gene expression data for Peripheral Vascular Disease.

Pathways for genes affiliated with Peripheral Vascular Disease

About this section
Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 52R&D Systems, 49PharmGKB
See all sources

Pathways related to Peripheral Vascular Disease according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3APOA1, APOB
210.2CETP, LPA, APOB
310.2SELP, LPA, APOB
410.2SELE, VCAM1, APOA1
510.2SELP, SELE, APOB
610.2ALB, CETP, APOB
710.2APOB, VWF, CETP
8
Hide members
10.2APOA1, APOB, ALB
9
Hide members
10.2APOB, APOA2, APOA1
10
Hide members
10.1FGB, VWF, SERPINE1
1110.1PLTP, APOA2, APOA1
1210.1APOA1, APOB, SERPINE1, ALB
13
Hide members
10.1SERPINE1, VCAM1, VWF, FGB
14
Hide members
10.0APOA2, FGB, VWF, SERPINE1
1510.0APOA1, APOA2, APOB, LPA, ALB
16
Hide members
9.9APOA1, APOA2, APOB, LPA, CETP, ALB
17
Hide members
9.9FGB, VWF, SELE, SERPINE1, SELP, ALB
18
Hide members
9.9APOA1, APOA2, APOB, PLTP, HMGCR, CETP
19
Hide members
9.6ALB, APOA1, PPBP, PF4, FGB, VWF
20
Hide members
9.5APOA1, APOA2, APOB, PPBP, PF4, FGB

Compounds for genes affiliated with Peripheral Vascular Disease

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience
See all sources

Compounds related to Peripheral Vascular Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 230)
idCompoundScoreTop Affiliating Genes
1alpha tocopherol4410.7PLTP
2kininogen4410.5SERPINE1, ACE, VWF, APOB
3dextran sulfate4410.4APOA1, APOB, PLTP, SELP, CETP
4sele4410.4ACE, CETP, SELE, SELP, VCAM1
5quinapril44 1111.3SERPINE1, SELE, ACE, SELP, VWF
6vitamin a44 11 2412.3CETP, LPA, APOB, APOA1
7acipimox44 2811.3APOB, HMGCR, APOA1, CETP, PLTP
8gemfibrozil44 28 1112.3SERPINE1, LPA, APOA1, APOB, APOA2, CETP
9iohexol4410.3APOA1, PPBP, ALB, SELP, PF4
10serine4410.3CETP, SELE, APOA2, HMGCR, KLK15
1111-dehydrothromboxane b24410.3SELP, SERPINE1, VWF, PF4, PPBP
12warfarin44 49 11 2413.3PF4, PPBP, VWF, HMGCR, SELP, LPA
13probucol44 1111.2SELE, VCAM1, HMGCR, PLTP, APOB, APOA1
14phosphatidylcholine4410.2LPA, APOA2, APOA1, APOB, CETP, PLTP
15amlodipine44 49 11 2413.2HMGCR, ALB, SERPINE1, VCAM1, ACE
16ticlopidine44 1111.2VWF, PF4, PPBP, SELP, HMGCR
17polysulfone4410.2PF4, SELP, PPBP, VWF, ALB, VCAM1
18bezafibrate44 28 1112.2SERPINE1, HMGCR, LPA, APOB, APOA2, APOA1
19hirudin4410.2SELP, VWF, SELE, SERPINE1, FGB, PF4
20losartan44 49 28 1113.2SELE, SERPINE1, VWF, SELP, ALB, ACE
21cholesterol ester4410.2HMGCR, CETP, APOA1, APOA2, APOB, LPA
22rosuvastatin44 49 28 1113.2APOB, HMGCR, CETP, APOA1, ALB
23triacylglycerol4410.1APOB, APOA2, PLTP, SERPINE1, CETP, APOA1
24thyroxine44 2411.1ALB, CETP, HMGCR, VWF, LPA, APOB
25clopidogrel49 44 11 2413.1SELP, PPBP, VWF, HMGCR, ACE
26fenofibric acid44 2811.1HMGCR, APOB, APOA1, SERPINE1
27pravastatin44 49 28 11 2414.1APOA1, APOB, LPA, HMGCR, VCAM1, SELE
28mspi4410.1APOA2, APOB, CETP, APOA1, LPA
29iloprost44 59 28 1113.1PPBP, PF4, SELE, VCAM1, SELP
30fluvastatin44 49 28 1113.1CETP, SELP, SERPINE1, SELE, VCAM1, HMGCR
31glucose4410.0APOA1, PLTP, PPBP, LPA, PF4, RARRES2
32atorvastatin44 49 28 11 2414.0CETP, SELP, SERPINE1, SELE, VCAM1, HMGCR
33homocysteine44 2411.0APOA1, APOB, LPA, VWF, VCAM1, SELE
34heparin44 28 11 2413.0APOA2, PPBP, LPA, HMGCR, VCAM1, SELE
35lovastatin44 49 59 28 1113.9SERPINE1, LPA, HMGCR, CETP, APOB, APOA1
36prostacyclin449.9VWF, HMGCR, ACE, VCAM1, SELE, SERPINE1
37histamine44 28 2411.9ALB, SELP, SELE, PF4, HMGCR, VCAM1
38simvastatin44 49 59 28 11 2414.9PLTP, VCAM1, HMGCR, SELE, SERPINE1, CETP
39fenofibrate44 49 1111.9CETP, SELP, SERPINE1, APOA1, APOA2, APOB
40lactate449.8APOA1, APOB, PPBP, PF4, ALB, VWF
41niacin44 1110.7CETP, HMGCR, LPA, APOB, APOA1
42aspirin44 49 28 2412.7PPBP, LPA, PF4, VWF, HMGCR, ACE
43vegf449.7SERPINE1, SELP, SELE, VCAM1, HMGCR, VWF
44creatinine449.7HMGCR, ACE, SELE, SERPINE1, SELP, ALB
45alanine449.7APOA1, APOB, PPBP, PF4, ALB, VWF
46cysteine449.6VCAM1, HMGCR, PPBP, RARRES2, VWF, PF4
47fibrinogen449.6FGB, VWF, VCAM1, SELE, SERPINE1, ALB
48testosterone44 59 11 2412.5SELE, KLK15, APOA1, ALB, CETP, SERPINE1
49lipid449.4PLTP, PF4, PPBP, APOB, APOA1, LPA
50cholesterol44 28 11 2412.3APOA1, APOA2, APOB, PPBP, LPA, PF4

GO Terms for genes affiliated with Peripheral Vascular Disease

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Sources:
16Gene Ontology
See all sources

Cellular components related to Peripheral Vascular Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1very-low-density lipoprotein particleGO:03436110.3APOB, APOA2, APOA1
2chylomicronGO:04262710.3APOB, APOA2
3high-density lipoprotein particleGO:03436410.3APOA1, APOA2, CETP
4spherical high-density lipoprotein particleGO:03436610.2APOA1, APOA2
5early endosomeGO:00576910.1VCAM1, APOB, APOA2, APOA1
6external side of plasma membraneGO:00989710.0FGB, VWF, ACE, MS4A2, VCAM1, SELP
7platelet alpha granule lumenGO:03109310.0PPBP, PF4, FGB, VWF, SERPINE1, ALB
8platelet alpha granuleGO:0310919.9VWF, FGB
9extracellular spaceGO:0056159.5APOA1, APOB, PPBP, PF4, FGB, ACE
10extracellular regionGO:0055769.1ALB, KLK15, APOA1, APOA2, APOB, PPBP

Biological processes related to Peripheral Vascular Disease according to GeneCards/GeneDecks:

(show all 34)
idNameGO IDScoreTop Affiliating Genes
1leukocyte tethering or rollingGO:05090110.6VCAM1, SELE, SELP
2lipoprotein biosynthetic processGO:04215810.6APOA1, APOB
3negative regulation of lipase activityGO:06019210.6APOA1, APOA2
4negative regulation of very-low-density lipoprotein particle remodelingGO:01090310.6APOA1, APOA2
5cholesterol transportGO:03030110.6APOA1, APOB, CETP
6regulation of intestinal cholesterol absorptionGO:03030010.6APOA2, APOA1
7low-density lipoprotein particle remodelingGO:03437410.6APOA2, APOB, CETP
8leukocyte cell-cell adhesionGO:00715910.6SELP, SELE, VCAM1
9heterophilic cell-cell adhesionGO:00715710.5SELP, SELE, VCAM1
10high-density lipoprotein particle remodelingGO:03437510.5APOA1, APOA2, CETP
11high-density lipoprotein particle assemblyGO:03438010.5APOA1, APOA2
12reverse cholesterol transportGO:04369110.5CETP, APOA2, APOA1
13protein oxidationGO:01815810.5APOA1, APOA2
14negative regulation of cytokine secretion involved in immune responseGO:00274010.5APOA1, APOA2
15cholesterol effluxGO:03334410.5APOA1, APOA2, APOB
16retinoid metabolic processGO:00152310.5APOA2, APOB, RARRES2
17negative regulation of wound healingGO:06104510.5HMGCR, SERPINE1
18cholesterol homeostasisGO:04263210.5APOA1, APOA2, APOB, CETP
19response to nutrientGO:00758410.5APOA1, HMGCR, VCAM1, ALB
20receptor-mediated endocytosisGO:00689810.5APOB, LPA, CETP
21cholesterol metabolic processGO:00820310.5CETP, APOB, APOA2, APOA1
22high-density lipoprotein particle clearanceGO:03438410.4APOA1, APOA2
23lipid transportGO:00686910.4LPA, PLTP, CETP
24peptidyl-methionine modificationGO:01820610.4APOA1, APOA2
25phospholipid homeostasisGO:05509110.4APOA1, CETP
26positive regulation of cholesterol esterificationGO:01087310.4APOA2, APOA1
27lipoprotein metabolic processGO:04215710.3APOA1, APOA2, APOB, LPA, CETP, ALB
28phototransduction, visible lightGO:00760310.2APOB, APOA2, APOA1
29phospholipid effluxGO:03370010.2APOA1, APOA2
30platelet degranulationGO:00257610.0ALB, APOA1, PPBP, PF4, FGB, VWF
31positive regulation of leukocyte migrationGO:00268710.0SELE, SELP
32platelet activationGO:03016810.0APOA1, PPBP, PF4, FGB, VWF, SERPINE1
33blood coagulationGO:0075969.8APOA1, APOB, PPBP, PF4, FGB, VWF
34small molecule metabolic processGO:0442819.8APOA1, APOA2, APOB, LPA, HMGCR, CETP

Molecular functions related to Peripheral Vascular Disease according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1oligosaccharide bindingGO:07049210.5SELE, SELP
2high-density lipoprotein particle receptor bindingGO:07065310.5APOA1, APOA2
3apolipoprotein receptor bindingGO:03419010.4APOA1, APOA2
4cholesterol bindingGO:01548510.4CETP, APOA2, APOA1
5phosphatidylcholine-sterol O-acyltransferase activator activityGO:06022810.4APOA1, APOA2
6cholesterol transporter activityGO:01712710.4CETP, APOB, APOA2, APOA1
7lipase inhibitor activityGO:05510210.3APOA1, APOA2
8heparin bindingGO:00820110.3APOB, LPA, PF4, SELP
9phospholipid transporter activityGO:00554810.3CETP, APOA1
10chaperone bindingGO:05108710.3ALB, VWF, FGB
11phosphatidylcholine bindingGO:03121010.3CETP, APOA2
12high-density lipoprotein particle bindingGO:00803510.2APOA1, APOA2
13sialic acid bindingGO:03369110.0SELP, SELE

Products for genes affiliated with Peripheral Vascular Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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36MGI
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40NDF-RT
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