MCID: PRP027
MIFTS: 65

Peripheral Vascular Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Peripheral Vascular Disease

MalaCards integrated aliases for Peripheral Vascular Disease:

Name: Peripheral Vascular Disease 39 38 12 3 14
Peripheral Arterial Disease 39 41 3
Arterial Occlusive Diseases 52 42 69
Arterial Occlusive Disease 39 38 12
Peripheral Vascular Diseases 52 69
Helicobacter Infections 42 69
Pad 39 3
Peripheral Occlusive Disease 39
Peripheral Arterial Diseases 69

Classifications:



External Ids:

Disease Ontology 12 DOID:341
ICD9CM 35 443.81
SNOMED-CT 64 195624006 2929001
ICD10 33 I73.8

Summaries for Peripheral Vascular Disease

MedlinePlus : 41 peripheral arterial disease (pad) happens when there is a narrowing of the blood vessels outside of your heart. the cause of pad is atherosclerosis. this happens when plaque builds up on the walls of the arteries that supply blood to the arms and legs. plaque is a substance made up of fat and cholesterol. it causes the arteries to narrow or become blocked. this can reduce or stop blood flow, usually to the legs. if severe enough, blocked blood flow can cause tissue death and can sometimes lead to amputation of the foot or leg. the main risk factor for pad is smoking. other risk factors include older age and diseases like diabetes, high blood cholesterol, high blood pressure, heart disease, and stroke. many people who have pad don't have any symptoms. if you have symptoms, they may include pain, numbness, achiness, or heaviness in the leg muscles. this happens when walking or climbing stairs. weak or absent pulses in the legs or feet sores or wounds on the toes, feet, or legs that heal slowly, poorly, or not at all a pale or bluish color to the skin a lower temperature in one leg than the other leg poor nail growth on the toes and decreased hair growth on the legs erectile dysfunction, especially among men who have diabetes pad can increase your risk of heart attack, stroke, and transient ischemic attack. doctors diagnose pad with a physical exam and heart and imaging tests. treatments include lifestyle changes, medicines, and sometimes surgery. lifestyle changes include dietary changes, exercise, and efforts to lower high cholesterol levels and high blood pressure. nih: national heart, lung, and blood institute

MalaCards based summary : Peripheral Vascular Disease, also known as peripheral arterial disease, is related to priapism and systemic lupus erythematosus, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Peripheral Vascular Disease is APOB (Apolipoprotein B), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall. The drugs Methyltestosterone and Testosterone have been mentioned in the context of this disorder. Affiliated tissues include Bone, bone and endothelial, and related phenotypes are Decreased free cholesterol and cardiovascular system

Disease Ontology : 12 A vascular disease that is characterized by obstruction of larger arteries not within the coronary, aortic arch vasculature, or brain.

CDC : 3 Peripheral Arterial Disease (PAD) in the Legs or lower extremities is the narrowing or blockage of the vessels that carry blood from the heart to the legs. It is primarily caused by the buildup of fatty plaque in the arteries, which is called atherosclerosis. PAD can occur in any blood vessel, but it is more common in the legs than the arms.

Related Diseases for Peripheral Vascular Disease

Diseases related to Peripheral Vascular Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 314)
id Related Disease Score Top Affiliating Genes
1 priapism 30.8 ALB SERPINC1 SERPINE1 THBD
2 systemic lupus erythematosus 27.9 ALB CRP F3 IL6 SELE THBD
3 peripheral artery disease 27.8 ACE ALB APOA1 APOB CRP F2
4 ischemic heart disease 26.3 ACE ALB CRP F2 IL6 SELP
5 myocardial infarction 22.4 ACE ALB APOA1 APOB CRP F2
6 angina pectoris 21.5 ACE ALB APOA1 APOB CRP F2
7 peripheral arterial occlusive disease 1 12.2
8 buerger disease 11.4
9 grange syndrome 11.2
10 vascular disease 10.9
11 unna-thost palmoplantar keratoderma 10.8 THBD VWF
12 ube2t-related fanconi anemia 10.8 SELP VWF
13 iron metabolism disease 10.7 ACE CRP SELP
14 retinitis pigmentosa 70 10.7 ACE ALB VEGFA
15 mesomelia 10.7 PLAT THBD
16 immunodeficiency 32b, monocyte and dendritic cell deficiency, autosomal recessive 10.7 PLAT THBD
17 epidural neoplasm 10.7 VEGFA VWF
18 adams-oliver syndrome 5 10.6 ACE CRP VWF
19 elizabethkingia anophelis infection 10.6 PLAT THBD VWF
20 esophageal leukoplakia 10.6 ALB VEGFA VWF
21 cystinosis 10.6 ACE ALB CRP
22 primary hyperoxaluria 10.6 ACE SERPINC1
23 dermatomycosis 10.6 ALB CRP SELE
24 craniosynostosis 7 10.6 ACE CRP VWF
25 non-hodgkin lymphoma, during pregnancy 10.6 ALB F2
26 phlegmonous dacryocystitis 10.6 SELE VCAM1 VEGFA
27 argyria 10.6 ACE F2
28 neonatal diabetes mellitus 10.5 SELE THBD VWF
29 chronic fungal otitis externa 10.5 CRP F2
30 familial osteochondritis dissecans 10.5 ALB APOA1
31 listeriosis 10.5 ACE VWF
32 intramuscular hemangioma 10.5 ALB CRP VWF
33 conjunctival disease 10.5 ACE PLAT SERPINC1
34 lymphomatous thyroiditis 10.5 SELE VCAM1
35 intermittent claudication 10.5
36 migraine with or without aura 1 10.5 APOA1 APOB LPA
37 intra-abdominal lymph node mast cell malignancy 10.4 ACE CRP SELP VCAM1
38 temporomandibular ankylosis 10.4 ACE CRP SELE SELP
39 split-hand/foot malformation 1 with sensorineural hearing loss 10.4 PLAT SERPINE1
40 bird fancier's lung 10.4 APOA1 APOB LPA
41 ovarian clear cell malignant adenofibroma 10.4 APOA1 APOB CRP
42 subacute leukemia 10.4 ACE PLAT SELP VEGFA
43 alzheimer disease-2 10.4 APOA1 APOB LPA
44 chondrocalcinosis with early-onset osteoarthritis 10.4 APOA1 APOB LPA
45 collagenopathy type 2 alpha 1 10.4 CRP IL6
46 hepatocellular adenoma 10.4 ACE CRP F2
47 amyloidosis nodular localized cutaneous 10.4 APOA1 CRP LPA
48 myopia 10.4 ACE ALB F2
49 hereditary amyloidosis 10.4 F3 SELP SERPINC1
50 apolipoprotein c-iii deficiency 10.4 APOA1 APOB LPA

Comorbidity relations with Peripheral Vascular Disease via Phenotypic Disease Network (PDN): (show top 50) (show all 98)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Myocardial Infarction
Anxiety Disorder Aortic Aneurysm
Aortic Atherosclerosis Autonomic Nervous System Disease
Basilar Artery Insufficiency Benign Essential Hypertension
Benign Renovascular Hypertension Bleeding Disorder, Platelet-Type, 11
Bronchitis Bronchopneumonia
Buerger Disease Cardiac Arrest
Cardiogenic Shock Cerebral Atherosclerosis
Cerebrovascular Disease Chronic Kidney Failure
Chronic Myocardial Ischemia Chronic Pulmonary Heart Disease
Chronic Ulcer of Skin Decubitus Ulcer
Deficiency Anemia Dermatomycosis
Diabetic Peripheral Angiopathy Diabetic Polyneuropathy
Dressler's Syndrome Dysthymic Disorder
Encephalopathy Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Esophagitis Familial Atrial Fibrillation
First-Degree Atrioventricular Block Gas Gangrene
Generalized Atherosclerosis Gout
Heart Conduction Disease Heart Disease
Hyperlipidemia, Familial Combined Hyperlipoproteinemia Type Iv
Hypertension, Essential Hypertensive Encephalopathy
Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Hypoglycemia
Hypoglycemic Coma Hypothyroidism
Intermediate Coronary Syndrome Intracranial Embolism

Graphical network of the top 20 diseases related to Peripheral Vascular Disease:



Diseases related to Peripheral Vascular Disease

Symptoms & Phenotypes for Peripheral Vascular Disease

UMLS symptoms related to Peripheral Vascular Disease:


angina pectoris, chest pain, edema

GenomeRNAi Phenotypes related to Peripheral Vascular Disease according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 8.92 APOA1 APOB LPA SELP

MGI Mouse Phenotypes related to Peripheral Vascular Disease:

44 (show all 14)
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.44 F2 F3 IL6 PLAT SELE SELP
2 homeostasis/metabolism MP:0005376 10.39 VWF ACE ALB APOA1 APOB CRP
3 immune system MP:0005387 10.31 ACE APOB CRP F2 F3 IL6
4 cellular MP:0005384 10.3 ALB APOA1 APOB F3 IL6 PLAT
5 hematopoietic system MP:0005397 10.29 ACE F2 F3 IL6 PLAT SELE
6 growth/size/body region MP:0005378 10.27 ACE APOB F2 F3 IL6 PLAT
7 mortality/aging MP:0010768 10.2 ALB APOB F2 F3 IL6 PLAT
8 liver/biliary system MP:0005370 10.11 ACE ALB APOA1 APOB IL6 SELE
9 integument MP:0010771 10.06 APOA1 F2 F3 IL6 SELE SELP
10 digestive/alimentary MP:0005381 10.05 ALB F2 IL6 PLAT THBD VEGFA
11 renal/urinary system MP:0005367 9.86 SERPINE1 THBD VEGFA ACE ALB IL6
12 reproductive system MP:0005389 9.81 PLAT SERPINC1 THBD VCAM1 VEGFA ACE
13 respiratory system MP:0005388 9.61 IL6 PLAT SELE SELP SERPINE1 THBD
14 vision/eye MP:0005391 9.23 APOB F3 IL6 PLAT SELE SELP

Drugs & Therapeutics for Peripheral Vascular Disease

Drugs for Peripheral Vascular Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 527)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyltestosterone Approved Phase 4 58-18-4 6010
2
Testosterone Approved, Investigational Phase 4 58-22-0 6013
3
Paclitaxel Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 33069-62-4 36314
4
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Early Phase 1 50-78-2 2244
5
Cilostazol Approved Phase 4,Phase 3,Phase 2,Phase 1 73963-72-1 2754
6
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
7
Metformin Approved Phase 4,Phase 3 657-24-9 14219 4091
8
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3 2180-92-9, 38396-39-3 2474
9
Clonidine Approved Phase 4 4205-90-7 2803
10
Levobupivacaine Approved Phase 4 27262-47-1 92253
11
Morphine Approved, Investigational Phase 4 57-27-2 5288826
12
Simvastatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 79902-63-9 54454
13
Dalteparin Approved Phase 4,Phase 3,Phase 1 9005-49-6
14
Heparin Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 9005-49-6 772 46507594
15
Enalapril Approved, Vet_approved Phase 4,Phase 1,Phase 2 75847-73-3 5362032 40466924
16
Enalaprilat Approved Phase 4,Phase 1,Phase 2 76420-72-9 6917719
17
Nitric Oxide Approved Phase 4,Phase 2,Phase 1,Early Phase 1 10102-43-9 145068
18
Menthol Approved Phase 4,Phase 2,Phase 3 2216-51-5 16666
19
Alprostadil Approved, Investigational Phase 4,Phase 3,Phase 2 745-65-3 149351
20
Everolimus Approved Phase 4,Phase 2,Phase 3,Phase 1 159351-69-6 6442177
21
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 22916-47-8 4189
22
Sirolimus Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 53123-88-9 5284616 6436030 46835353
23
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
24
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 137-58-6 3676
25
Nitroglycerin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 55-63-0 4510
26
Pravastatin Approved Phase 4,Phase 3,Phase 1 81093-37-0 54687
27
Metoprolol Approved, Investigational Phase 4,Phase 3,Phase 1 37350-58-6, 51384-51-1 4171
28
Allopurinol Approved Phase 4 315-30-0 2094
29
Ramipril Approved Phase 4 87333-19-5 5362129
30
Ezetimibe Approved Phase 4,Phase 3 163222-33-1 150311
31
Ticlopidine Approved Phase 4,Phase 3,Phase 2 55142-85-3 5472
32 Defibrotide Approved, Investigational Phase 4 83712-60-1
33
Iloprost Approved, Investigational Phase 4,Phase 3,Phase 2 78919-13-8 6443959
34
Pentoxifylline Approved, Investigational Phase 4,Phase 3 6493-05-6 4740
35
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
36
Valsartan Approved, Investigational Phase 4,Phase 2,Phase 1 137862-53-4 60846
37
Amlodipine Approved Phase 4,Phase 2,Phase 3 88150-42-9 2162
38
Pioglitazone Approved, Investigational Phase 4,Phase 2,Phase 3,Early Phase 1 111025-46-8 4829
39
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
40
Insulin Glargine Approved Phase 4 160337-95-1
41
Insulin Lispro Approved Phase 4 133107-64-9
42
Zinc Approved Phase 4,Phase 1 7440-66-6 32051 23994
43
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
44
Ibuprofen Approved Phase 4 15687-27-1 3672
45
Glipizide Approved Phase 4 29094-61-9 3478
46 Magnesium citrate Approved Phase 4
47
Magnesium oxide Approved Phase 4 1309-48-4 14792
48
Ticagrelor Approved Phase 4,Phase 3,Phase 2,Phase 1 274693-27-5 9871419
49
Lercanidipine Approved, Investigational Phase 4 100427-26-7 65866
50
Losartan Approved Phase 4,Early Phase 1 114798-26-4 3961

Interventional clinical trials:

(show top 50) (show all 1275)

id Name Status NCT ID Phase Drugs
1 Testosterone for Peripheral Vascular Disease Unknown status NCT00504712 Phase 4 Testosterone;0.9% saline
2 Efficacy Study of Stenting, Paclitaxel Eluting Balloon or Atherectomy to Treat Peripheral Artery Disease Unknown status NCT00986752 Phase 4
3 Multifactorial Intervention on Cardiovascular Risk Factors in Subjects With Peripheral Arterial Disease Unknown status NCT00144937 Phase 4 Stepwise therapy for dyslipidemia, hypertension and diabetes
4 Paclitaxel Eluting Balloon and Conventional Balloon for In-Stent Restenosis of the Superficial Femoral Artery Unknown status NCT01083394 Phase 4
5 Residual Platelet Activity In Advanced Peripheral Artery Disease Unknown status NCT01627431 Phase 4 Acetylsalicylic acid;Clopidogrel
6 A Multicenter, Therapeutic Used Study to Evaluate the Efficacy and Safety of Pletaal SR Capsule (Cilostazol) in Subjects With Peripheral Arterial Disease Symptom Due to Chronic Occlusive Arterial Disease Unknown status NCT01711333 Phase 4 Pletaal SR capsule
7 Platelets Induced Vasodilation, in Vitro and in Vivo Study Unknown status NCT00152646 Phase 4 placebo, aspirine, clopidogrel
8 Efficacy of Self-Expanding Nitinol S.M.A.R.T CONTROL Stent Versus Life Stent For The Atherosclerotic Femoro-Popliteal Arterial Disease Unknown status NCT01653600 Phase 4
9 Paclitaxel Eluting Stent or Exercise for Thigh Atherosclerosis Unknown status NCT02033135 Phase 4
10 Metformin, Muscle Energetics, and Vascular Function in Older Adults With Peripheral Artery Disease Unknown status NCT01901224 Phase 4 Metformin 1000 mg;Placebo
11 Aspirin Resistance and Prognosis of Patients With Critical Limb Ischaemia Unknown status NCT01104441 Phase 4
12 Safety and Efficacy Study of OmniWave Endovascular System to Treat Deep Vein Thrombosis Unknown status NCT00640731 Phase 4
13 Far Infrared Therapy on Peripheral Artery Disease in Hemodialysis Patients Unknown status NCT01095549 Phase 4
14 Drug Eluting Balloon in peripherAl inTErvention for Below-The-Knee Arteries With Freeway and Lutonix Unknown status NCT02279784 Phase 4
15 Paclitaxel-eluting Balloon Angioplasty With Provisional Use of Nitinol Stent Versus Systematic Implantation of Paclitaxel-eluting Stent for the Treatment of Femoropopliteal de Novo Lesions Unknown status NCT01969630 Phase 4
16 Interest of a Bi-truncal Nerve Block (Femoral + Sciatic) Extended, Systematically Associated With General Anesthesia, in the Femoropopliteal Bypass: Study of Post-operative Analgesia and Peripheral Circulation Downstream Unknown status NCT01785693 Phase 4 levobupivacaine, clonidine
17 Cilostazol Versus Aspirin for Primary Prevention of Atherosclerotic Events Unknown status NCT00886574 Phase 4 Cilostazol;Aspirin
18 Effects of Nicotinic Acid Plus Simvastatin Versus Simvastatin Alone on Carotid and Femoral Intima-Media Thickness in Patients With Peripheral Artery Disease (NASCIT) Unknown status NCT00712049 Phase 4 simvastatin;Nicotinic Acid
19 Prevalence of Macrovascular Disease in Type 2 Diabetes Mellitus Unknown status NCT00298844 Phase 4
20 Efficacy of Low Molecular Weight Heparin in Superficial Vein Thrombosis Unknown status NCT01245998 Phase 4 Dalteparin;Dalteparin
21 Clinical Evaluation of the SNaP Wound Care System Unknown status NCT01113658 Phase 4
22 Anti-Hypertensive Agent (ACEi) and Heart Function Improvement in Association With Rho Kinase Activity Changes in Human Unknown status NCT01069042 Phase 4 Enalapril
23 Comparison of Stent and Prothesis Bypass in Superficial Femoral Artery Unknown status NCT01147419 Phase 4
24 Effects of Cilostazol on VEGF and Oxidative Stress Biomarkers in Hemodialysis Patients With Peripheral Vascular Disease Completed NCT00431249 Phase 4 Cilostazol
25 Long-term Pleiotropic Effect of Statins in Patients With Peripheral Arterial Disease Completed NCT01041729 Phase 4 Atorvastatin;Standard Medical Treatment
26 Prevention of Ischemic Events in Patients With Peripheral Arterial Disease Completed NCT00761969 Phase 4
27 Allopurinol as a Possible Oxygen Sparing Agent During Exercise in Peripheral Arterial Disease Completed NCT01147705 Phase 4 Allopurinol;Placebo
28 Angiotensin Converting Enzyme (ACE) Inhibition and Peripheral Arterial Disease Completed NCT00681226 Phase 4 Ramipril or matching placebo
29 Intermittent Mechanical Compression For Peripheral Arterial Disease Completed NCT00855673 Phase 4 Control
30 The Effects of Ramipril on Clinical Symptoms in Patients With Peripheral Arterial Disease Completed NCT00168467 Phase 4 Ramipril
31 Effectiveness of Intensive Lipid Modification Medication in Preventing the Progression of Peripheral Arterial Disease (The ELIMIT Study) Completed NCT00687076 Phase 4 Ezetimibe;Niaspan;Statin therapy;Aspirin;Clopidogrel;Placebo Niaspan;Placebo Ezetimibe
32 Testosterone Replacement in Diabetes With Vascular Disease (Version 2) Completed NCT00355537 Phase 4 Testosterone;0.9% saline
33 The Effects of Physical Training, ASA (Aspirin), and Clopidogrel on the Walking Capacity of Patients With Stage II Peripheral Arterial Disease (PAD) Completed NCT00189618 Phase 4 Aspirin;Clopidogrel
34 GORE VIABAHN ENDOPROSTHESIS Peripheral Vascular Disease Study Completed NCT00228384 Phase 4
35 The Jetstream G3™ Calcium Study Completed NCT01273623 Phase 4
36 A Study to Collect Intravascular Ultrasound Images Before and After Treatment With the Jetstream System Completed NCT00911417 Phase 4
37 The Safety and Efficacy of Cilostazol in Ischemic Stroke Patients With Peripheral Arterial Disease (SPAD Study) Completed NCT01188824 Phase 4 Cilostazol
38 Efficacy Evaluation of Dotarem Compared to Gadovist in the Diagnosis of Peripheral Arterial Disease Completed NCT01026389 Phase 4 Dotarem;Gadovist
39 GORE VIABAHN® Versus Plain Old Balloon Angioplasty (POBA) for Superficial Femoral Artery (SFA) In-Stent Restenosis Completed NCT01108861 Phase 4
40 4-EVER : a Trial Investigating the Safety of 4F Endovascular Treatment of Infra-Inguinal Arterial Stenotic Disease Completed NCT01413139 Phase 4
41 Angioplasty in Peripheral Arterial Disease and Endothelial Function Completed NCT00660634 Phase 4
42 The Jetstream (JET) Post-market Registry Completed NCT01436435 Phase 4
43 Peripheral Vascular Disease and Nerve Stimulation Completed NCT01942941 Phase 4
44 ASSESS Study: Evaluation of ABSOLUTE™ Stent System for Occluded Arteries Completed NCT00180505 Phase 4
45 Physician-Initiated Trial Investigating the BeGraft Peripheral Stent Graft System Completed NCT02211716 Phase 4
46 Prospective, Non-randomized Multi-center, Controlled Physician-initiated Trial: Rotarex Belgium In-stent Occlusion Completed NCT02212626 Phase 4
47 Standard Balloon Angioplasty Versus Angioplasty With a Paclitaxel-eluting Balloon for Femoral Artery In-stent Restenosis Completed NCT01305070 Phase 4
48 Drug Eluting Balloon in peripherAl inTErvention SFA Completed NCT01556542 Phase 4
49 NanoCross BTK, a Prospective, Non-randomized, Multicenter, Controlled Trial Evaluating the Performance of the NanoCrossTM .014 Balloon Catheter in Infrapopliteal Lesions Completed NCT01783600 Phase 4
50 DOTAREM®-Enhanced MRA Compared to GADOVIST®-Enhanced MRA in Patients With Abdominal or Lower Limb Arterial Diseases Completed NCT00955617 Phase 4

Search NIH Clinical Center for Peripheral Vascular Disease

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Peripheral Vascular Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Peripheral Vascular Disease:
ACY001, bone marrow-derived hematopoietic stem cells for coronary artery occlusions
ALD-301, bone marrow-derived cells for critical limb ischemia
Alecmestencel-T, mesenchymal stem cells for ischemic diseases
ALO212, umbilical cord blood-derived stem cell concentrate for vascular diseases
Autologus endothelial progenitor cells for the treatment of critical limb ischemia
Autologus hematopoeitic stem cells for the treatment of critical limb ischemia
Bone marrow-derived CD133+ or nucleated cells for peripheral artery disease
Bone marrow-derived mononuclear cells for peripheral vascular disease
Bone marrow-derived mononuclear stem cells for treatment of critical limb ischemia
Endothelial progenitor cells for peripheral artery disease
Enriched bone marrow-derived progenitor cells for ischemic diseases
MultiGeneAngio, genetically modified endothelial and smooth muscle cells for vascular disease
MultiStem
Peripheral blood-derived hematopoietic stem cells for leg gangrene
TGI PVG, adipose-derived stem cell-coated vascular graft for peripheral vascular disease
VASCUGEL
Embryonic/Adult Cultured Cells Related to Peripheral Vascular Disease:
Bone marrow-derived CD133+ stem cells
Bone marrow-derived ALDH+ cells (ALD) PMIDs: 10430905 19324906
Bone marrow-derived mesenchymal stem cells (family)
Cord blood-derived hematopoietic stem cell PMIDs: 19558779
Peripheral blood-derived endothelial cells PMIDs: 19448678 18388019
Peripheral blood-derived hematopoietic stem cells PMIDs: 18388019
Bone marrow-derived mononuclear cells (family)
Bone marrow-derived mononuclear cells
Bone marrow-derived mononuclear cells
Peripheral blood-derived endothelial progenitor cells PMIDs: 10725398
Bone marrow-derived progenitor cells
MultiGeneAngio, transduced vein-derived endothelial cells
MultiGeneAngio, transduced vein-derived smooth muscle cells
Genetically modified vein-derived smooth muscle
Genetically modified vein-derived endothelial cells
Bone marrow-derived adherent progenitor cells (MultiStem) PMIDs: 21175285 23307829
Peripheral blood-derived hematopoietic stem cells
Adipose-derived stromal cells PMIDs: 8207032 23350681
Aortic endothelial cells cultured in matrix PMIDs: 7667257
Aortic endothelial cells cultured in matrix (VASCUGEL PMIDs: 7667257

Cochrane evidence based reviews: arterial occlusive diseases

Genetic Tests for Peripheral Vascular Disease

Anatomical Context for Peripheral Vascular Disease

MalaCards organs/tissues related to Peripheral Vascular Disease:

39
Bone, Endothelial, Heart, Bone Marrow, Testes, Kidney, Skin
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Peripheral Vascular Disease:
id Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate

Publications for Peripheral Vascular Disease

Articles related to Peripheral Vascular Disease:

(show top 50) (show all 589)
id Title Authors Year
1
Peripheral Vascular Disease: Treatment in Older Adults. ( 28145673 )
2017
2
Non-reconstructable peripheral vascular disease of the lower extremity in ten patients treated with adipose-derived stromal vascular fraction cells. ( 27984756 )
2017
3
Marrow-isolated adult multilineage inducible cells embedded within a biologically-inspired construct promote recovery in a mouse model of peripheral vascular disease. ( 28211362 )
2017
4
Social, demographic and clinical characteristics of patients suffering from peripheral vascular disease treated surgically compared to patients treated with endovascular angioplasty. ( 28905042 )
2017
5
Insidious incrementalism: The silent failure of the microcirculation with increasing peripheral vascular disease risk. ( 28236373 )
2017
6
Wearable Sensor Technology Efficacy in Peripheral Vascular Disease (wSTEP): A Randomized Controlled Trial. ( 28498233 )
2017
7
Evaluation of hyperspectral imaging technology in patients with peripheral vascular disease. ( 28545710 )
2017
8
Use of p53-Silenced Endothelial Progenitor Cells to Treat Ischemia in Diabetic Peripheral Vascular Disease. ( 28365567 )
2017
9
Polyarteritis nodosa presenting as peripheral vascular disease and acute limb ischemia. ( 27853042 )
2017
10
Polyarteritis nodosa presenting as peripheral vascular disease and acute limb ischemia. ( 28397742 )
2017
11
The Role of the Profundoplasty in the Modern Management of Patient with Peripheral Vascular Disease. ( 28549963 )
2017
12
Osseointegrated Transtibial Implants in Patients with Peripheral Vascular Disease: A Multicenter Case Series of 5 Patients with 1-Year Follow-up. ( 28926380 )
2017
13
Peripheral Vascular Disease in Patients with Diabetic Foot Ulcers - An Emerging Trend: A Prospective Study from North India. ( 28598042 )
2017
14
Peripheral Vascular Disease and Death in Southern European Kidney Transplant Candidates: A Competing Risk Modeling Approach: Erratum. ( 28738405 )
2017
15
Diabetes mellitus is a coronary heart disease risk equivalent for peripheral vascular disease. ( 28224925 )
2017
16
Efficacy and safety of aspirin in patients with peripheral vascular disease: An updated systematic review and meta-analysis of randomized controlled trials. ( 28403216 )
2017
17
Transverse versus Longitudinal Incisions for Femoral Artery Exposure in Treating Patients with Peripheral Vascular Disease. ( 28890060 )
2017
18
Reply to Letter to Editor regarding the article, "Polyarteritis nodosa presenting as peripheral vascular disease and acute limb ischemia". ( 28397743 )
2017
19
Mitochondrial Respiration after One Session of Calf Raise Exercise in Patients with Peripheral Vascular Disease and Healthy Older Adults. ( 27760222 )
2016
20
Trimetazidine hydrochloride as a new treatment for patients with peripheral vascular disease--an exploratory trial. ( 26813473 )
2016
21
Peripheral vascular disease in diabetic foot- A new trend. ( 27727607 )
2016
22
Prevalence of asymptomatic peripheral vascular disease in patients with type-2 diabetes mellitus by colour doppler study. ( 27728049 )
2016
23
An Experimental Model of Peripheral Vascular Disease Involving the Intravenous Injection of Oral Bacteria. ( 28018496 )
2016
24
Anesthesia for Patients with Peripheral Vascular Disease and Cardiac Dysfunction. ( 27816134 )
2016
25
Transcatheter Aortic Valve Implantation in Patients With Arterial Peripheral Vascular Disease. ( 27884643 )
2016
26
Comparison of colour duplex ultrasound & ankle brachial index in peripheral vascular disease in type 2 diabetes. ( 27727957 )
2016
27
SPECT and PET imaging of angiogenesis and arteriogenesis in pre-clinical models of myocardial ischemia and peripheral vascular disease. ( 27517840 )
2016
28
Novel Applications of Radionuclide Imaging in Peripheral Vascular Disease. ( 26590787 )
2016
29
Utility of Indocyanine Green Angiography in Arterial Selection during Free Flap Harvest in Patients with Severe Peripheral Vascular Disease. ( 27826489 )
2016
30
Treatment of a High-Risk Diabetic Patient with Peripheral Vascular Disease and Osteomyelitis. ( 27423990 )
2016
31
Evaluation of a novel 2D perfusion angiography technique independent of pump injections for assessment of interventional treatment of peripheral vascular disease. ( 27785678 )
2016
32
Ventricular Tachycardia: Inferior Vena Cava Filter in a Case of Peripheral Vascular Disease. ( 26794288 )
2016
33
Association between Bacterial Infection and Peripheral Vascular Disease: A Review. ( 26900306 )
2016
34
Hemorheological parameters better classify metabolic syndrome than novel cardiovascular risk factors and peripheral vascular disease marker. ( 26890105 )
2016
35
Mortality After Nontraumatic Major Amputation Among Patients WithA Diabetes and Peripheral Vascular Disease: A Systematic Review. ( 26898398 )
2016
36
Peripheral Vascular Disease and Death in Southern European Kidney Transplant Candidates: A Competing Risk Modeling Approach. ( 27379552 )
2016
37
Neutrophil lymphocyte ratio in peripheral vascular disease: a review. ( 26967241 )
2016
38
Identifying beliefs about smoking in patients with peripheral vascular disease. ( 27863591 )
2016
39
The Discovery of Novel Genomic, Transcriptomic, and Proteomic Biomarkers in Cardiovascular and Peripheral Vascular Disease: The State of the Art. ( 27298828 )
2016
40
Increased peripheral vascular disease risk progressively constrains perfusion adaptability in the skeletal muscle microcirculation. ( 26702145 )
2016
41
A balloon-expandable sheath facilitates transfemoral TAVR in patients with peripheral vascular disease and tortuosity. ( 25784499 )
2015
42
Radiotracer Imaging of Peripheral Vascular Disease. ( 26338845 )
2015
43
Microsecond-pulsed dielectric barrier discharge plasma stimulation of tissue macrophages for treatment of peripheral vascular disease. ( 26543345 )
2015
44
Peripheral vascular disease: shaping a new panvascular interventional approach. ( 26603982 )
2015
45
Comparison of vancomycin and linezolid in patients with peripheral vascular disease and/or diabetes in an observational European study of complicated skin and soft-tissue infections due to methicillin-resistant Staphylococcus aureus. ( 26198370 )
2015
46
Complex nonlinear autonomic nervous system modulation link cardiac autonomic neuropathy and peripheral vascular disease. ( 25870563 )
2015
47
Thoracic sympathectomy for peripheral vascular disease can lead to severe bronchospasm and excessive bronchial secretions. ( 25624604 )
2015
48
Pathophysiology and burden of infection in patients with diabetes mellitus and peripheral vascular disease: focus on skin and soft-tissue infections. ( 26198368 )
2015
49
Advances in axial imaging of peripheral vascular disease. ( 26285590 )
2015
50
A systematic review of the incidence and prevalence of cardiac, cerebrovascular, and peripheral vascular disease in multiple sclerosis. ( 25533300 )
2015

Variations for Peripheral Vascular Disease

Expression for Peripheral Vascular Disease

Search GEO for disease gene expression data for Peripheral Vascular Disease.

Pathways for Peripheral Vascular Disease

Pathways related to Peripheral Vascular Disease according to GeneCards Suite gene sharing:

(show all 13)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.55 ALB APOA1 APOB F2 F3 PLAT
2
Show member pathways
12.13 APOB F2 SELE SELP THBD
3
Show member pathways
12.01 F2 F3 PLAT SERPINC1 SERPINE1 THBD
4 11.97 PLAT SELE THBD VCAM1 VEGFA
5 11.92 ALB IL6 VCAM1 VEGFA
6 11.84 F2 F3 PLAT SERPINC1 SERPINE1 THBD
7
Show member pathways
11.56 IL6 SELE VCAM1 VEGFA
8 11.5 F3 IL6 SELE SERPINE1 THBD VCAM1
9 11.4 IL6 SELE SELP VCAM1
10 11.4 APOB IL6 LPA PLAT SELP
11 11.33 ALB APOA1 F2
12 11.21 APOA1 IL6 SELE VCAM1
13 10.64 PLAT SERPINE1

GO Terms for Peripheral Vascular Disease

Cellular components related to Peripheral Vascular Disease according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.88 APOA1 F3 PLAT THBD VCAM1 VEGFA
2 extracellular region GO:0005576 9.83 ACE ALB APOA1 APOB CRP F2
3 blood microparticle GO:0072562 9.78 ALB APOA1 F2 SERPINC1
4 external side of plasma membrane GO:0009897 9.77 ACE F2 IL6 SELP VCAM1
5 extracellular matrix GO:0031012 9.73 F3 PLAT SERPINE1 VWF
6 endoplasmic reticulum lumen GO:0005788 9.73 ALB APOA1 APOB F2 IL6 SERPINC1
7 platelet alpha granule lumen GO:0031093 9.55 ALB PPBP SERPINE1 VEGFA VWF
8 extracellular space GO:0005615 9.55 ACE ALB APOA1 APOB CRP F2
9 chylomicron GO:0042627 9.49 APOA1 APOB
10 intermediate-density lipoprotein particle GO:0034363 9.46 APOA1 APOB
11 extracellular exosome GO:0070062 10.1 ACE ALB APOA1 APOB CRP F2

Biological processes related to Peripheral Vascular Disease according to GeneCards Suite gene sharing:

(show all 30)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.96 CRP IL6 PPBP SELE SELP
2 post-translational protein modification GO:0043687 9.92 ALB APOA1 APOB IL6 SERPINC1
3 leukocyte migration GO:0050900 9.83 APOB F2 SELE SELP THBD
4 response to nutrient GO:0007584 9.8 APOA1 SERPINC1 VCAM1
5 cellular protein metabolic process GO:0044267 9.8 ALB APOA1 APOB F2 IL6 SERPINC1
6 defense response to Gram-negative bacterium GO:0050829 9.79 IL6 SELP SERPINE1
7 response to wounding GO:0009611 9.77 F2 IL6 VWF
8 blood coagulation GO:0007596 9.73 F2 F3 PLAT SERPINC1 THBD VWF
9 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.71 SELE SELP VCAM1
10 acute-phase response GO:0006953 9.67 CRP F2 IL6
11 acute inflammatory response GO:0002526 9.65 IL6 VCAM1
12 leukocyte cell-cell adhesion GO:0007159 9.65 SELE SELP VCAM1
13 low-density lipoprotein particle remodeling GO:0034374 9.64 APOB LPA
14 negative regulation of blood coagulation GO:0030195 9.64 SERPINE1 THBD
15 positive regulation of blood coagulation GO:0030194 9.63 F2 SERPINE1
16 positive regulation of positive chemotaxis GO:0050927 9.63 F3 VEGFA
17 fibrinolysis GO:0042730 9.63 F2 PLAT SERPINE1
18 leukocyte migration involved in inflammatory response GO:0002523 9.61 PPBP SELE
19 neutrophil mediated immunity GO:0002446 9.61 ACE IL6
20 chylomicron assembly GO:0034378 9.6 APOA1 APOB
21 negative regulation of lipid storage GO:0010888 9.58 CRP IL6
22 negative regulation of platelet activation GO:0010544 9.58 F2 THBD
23 leukocyte tethering or rolling GO:0050901 9.58 SELE SELP VCAM1
24 chylomicron remodeling GO:0034371 9.57 APOA1 APOB
25 lipoprotein biosynthetic process GO:0042158 9.55 APOA1 APOB
26 hemostasis GO:0007599 9.55 F2 F3 SERPINC1 THBD VWF
27 negative regulation of fibrinolysis GO:0051918 9.54 F2 SERPINE1 THBD
28 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.51 ACE VEGFA
29 response to lipopolysaccharide GO:0032496 9.5 APOB IL6 PPBP SELE SELP THBD
30 platelet degranulation GO:0002576 9.17 ALB APOA1 PPBP SELP SERPINE1 VEGFA

Molecular functions related to Peripheral Vascular Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.73 F2 F3 LPA PLAT
2 phospholipid binding GO:0005543 9.58 APOA1 APOB F3
3 growth factor activity GO:0008083 9.46 F2 IL6 PPBP VEGFA
4 sialic acid binding GO:0033691 9.37 SELE SELP
5 oligosaccharide binding GO:0070492 9.32 SELE SELP
6 protease binding GO:0002020 9.26 F3 SERPINC1 SERPINE1 VWF
7 heparin binding GO:0008201 9.1 APOB F2 LPA SELP SERPINC1 VEGFA
8 protein binding GO:0005515 10.16 ALB APOA1 APOB CRP F2 F3

Sources for Peripheral Vascular Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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