MCID: PRP028
MIFTS: 40

Peripheral Vertigo malady

Ear diseases category
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Summaries for Peripheral Vertigo

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33MalaCards
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MalaCards: Peripheral Vertigo, also known as vertigo, peripheral, is related to blindness and thrombophlebitis. An important gene associated with Peripheral Vertigo is GAD1 (glutamate decarboxylase 1 (brain, 67kDa)), and among its related pathways are Selected targets of HNF1 and Selenium Pathway. The compounds celite and aprosulate have been mentioned in the context of this disorder. Related mouse phenotypes are embryogenesis and cardiovascular system.

Aliases & Classifications for Peripheral Vertigo

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Sources:
8Disease Ontology, 62UMLS, 58SNOMED-CT, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear diseases


Aliases & Descriptions:

peripheral vertigo 8
vertigo, peripheral 62


External Ids:

Disease Ontology8 DOID:9847
ICD9CM27 386.19, 386.1

Related Diseases for Peripheral Vertigo

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Peripheral Vertigo via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1blindness10.3
2thrombophlebitis10.1APOH
3retinal artery occlusion10.1APOH
4central retinal vein occlusion10.1APOH
5factor xii deficiency10.1F3
6carotid artery thrombosis10.1F3
7purpura fulminans10.1SERPINC1
8factor viii deficiency10.1F3
9purpura10.1SERPINC1
10sagittal sinus thrombosis10.1SERPINC1
11eclampsia10.1SERPINC1
12stiff-person syndrome10.1
13meniere's disease10.1
14hypersplenism10.1F2
15systemic lupus erythematosus10.1CRP
16sneddon syndrome10.0APOH, SERPINC1
17hepatic vein thrombosis10.0APOH, SERPINC1
18retinal vein occlusion10.0APOH, SERPINC1
19thrombotic thrombocytopenic purpura, acquired10.0APOH, F3
20severe pre-eclampsia10.0APOH, SERPINC1
21hellp syndrome10.0APOH, SERPINC1
22blood platelet disease10.0SERPINC1, F3
23behcet's disease10.0APOH, CRP
24coronary thrombosis10.0SERPINC1, F3
25hemolytic anemia10.0F3, APOH
26glucose intolerance10.0GAD1, CRP
27rheumatic disease10.0APOH, CRP
28factor x deficiency10.0F3, F2
29factor v deficiency10.0F2, F3
30vitamin k deficiency hemorrhagic disease10.0F2, F3
31factor xi deficiency10.0F2, F3
32von willebrand's disease10.0F2, F3
33afibrinogenemia10.0F2, F3
34blood protein disease10.0F2, SERPINC1
35portal vein thrombosis10.0SERPINC1, F2
36hemophilia b10.0F3, F2
37dysfibrinogenemia10.0F2, SERPINC1
38placental abruption10.0F2, SERPINC1
39galactosemia10.0F2, F3
40intracranial thrombosis10.0APOH, SERPINC1, F3
41prion disease10.0SERPINC1, F3
42sjogren's syndrome10.0GAD1, APOH
43peritonitis10.0F2, CRP
44respiratory failure10.0CRP, F3, SERPINC1
45septic shock10.0CRP, F3, SERPINC1
46acute myocardial infarction10.0SERPINC1, F3, CRP
47connective tissue disease10.0F2, APOH, F3
48diabetes mellitus10.0GAD1, CRP, SERPINC1
49vasculitis10.0CRP, APOH, F2
50prothrombin deficiency10.0F2, APOH, SERPINC1

Graphical network of the top 20 diseases related to Peripheral Vertigo:



Diseases related to peripheral vertigo

Symptoms for Peripheral Vertigo

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Drugs & Therapeutics for Peripheral Vertigo

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Peripheral Vertigo

Search NIH Clinical Center for Peripheral Vertigo

Genetic Tests for Peripheral Vertigo

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Anatomical Context for Peripheral Vertigo

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Animal Models for Peripheral Vertigo or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Peripheral Vertigo:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.0F2, SERPINC1, F3, GAD1
2MP:00053858.0CRP, F3, SERPINC1, F2
3MP:00107687.3F2, APOH, SERPINC1, F3, GAD1
4MP:00053767.1GAD1, CRP, F3, SERPINC1, APOH, F2

Publications for Peripheral Vertigo

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52PubMed
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Articles related to Peripheral Vertigo:

(show all 30)
idTitleAuthorsYear
1
Evaluation of the effect of nimodipine o.d. (extended release) vs nimodipine t.i.d. in the treatment of peripheral vertigo. (23808594)
2013
2
Comparison of the effectiveness of intravenous piracetam and intravenous dimenhydrinate in the treatment of acute peripheral vertigo in the emergency department. (24276103)
2013
3
Cerebellar infarctions mimicking acute peripheral vertigo: how to avoid misdiagnosis? (23307911)
2013
4
Letter to the editor on "Cerebellar infarctions mimicking acute peripheral vertigo: how to avoid misdiagnosis?". (23633500)
2013
5
Response to: "Cerebellar infarctions mimicking acute peripheral vertigo," from Yeo et al. (23633501)
2013
6
An easy diagnostic tool distinguishing lateral medullary infarction from peripheral vertigo. (21855212)
2012
7
Medullary infarction after vertebral artery dissection presenting as acute peripheral vertigo. (21307810)
2011
8
Sonographic examination of epiaortic vessels in patients with peripheral vertigo. (23396499)
2010
9
Is surgical vestibular ablation necessary in disabling peripheral vertigo? (23120494)
2008
10
Stiff-person syndrome with acute recurrent peripheral vertigo: possible evidence of gamma aminobutyric acid as a neurotransmitter in the vestibular periphery. (17666138)
2008
11
Role of C-reactive protein, D-dimer, and fibrinogen levels in the differential diagnosis of central and peripheral vertigo. (18029334)
2007
12
Intracranial vertebral artery dissection mimicking acute peripheral vertigo. (16428195)
2006
13
Surgical treatment of peripheral vertigo and vertiginous diseases. (15637415)
2005
14
Intratympanic gentamicin for the treatment of Meniere's disease and other forms of peripheral vertigo. (15474112)
2004
15
Acute peripheral vertigo: involvement of the hemostatic system. (15106288)
2003
16
Relevance of plasma D-dimer measurement in patients with acute peripheral vertigo. (12818056)
2003
17
New approaches to the management of peripheral vertigo: efficacy and safety of two calcium antagonists in a 12-week, multinational, double-blind study. (11981396)
2002
18
A study on peripheral vertigo in a Kolkata based hospital. (23119868)
2002
19
Intramuscular droperidol versus intramuscular dimenhydrinate for the treatment of acute peripheral vertigo in the emergency department: a randomized clinical trial. (12045085)
2002
20
Posterior fossa vestibular nerve section for the management of peripheral vertigo. (10392296)
1999
21
Droperidol for the treatment of acute peripheral vertigo. (9928721)
1999
22
3D analysis of nystagmus in peripheral vertigo. (9105433)
1997
23
Overall view and rationale for surgical alternatives for incapacitating peripheral vertigo. (8022608)
1994
24
Surgical treatment of incapacitating peripheral vertigo. Criteria for the evaluation of surgical results. (8022609)
1994
25
Peripheral vertigo. (3979333)
1985
26
Transdermal scopolamine for peripheral vertigo (a double-blind study). (3894551)
1985
27
Complications of treatment of peripheral vertigo. (6149924)
1984
28
Peripheral vertigo. (6499706)
1984
29
The causes of peripheral vertigo. (6499708)
1984
30
Betahistine in peripheral vertigo: a double-blind, placebo-controlled, cross-over study of Serc versus placebo. (7019369)
1981

Variations for Peripheral Vertigo

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Expression for genes affiliated with Peripheral Vertigo

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Peripheral Vertigo

Search GEO for disease gene expression data for Peripheral Vertigo.

Pathways for genes affiliated with Peripheral Vertigo

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Sources:
50PathCards, 12EMD Millipore, 38NCBI BioSystems Database, 55Reactome, 53QIAGEN, 30KEGG, 54R&D Systems
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Pathways related to Peripheral Vertigo according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CRP, APOH
2
Show member pathways
thioredoxin pathway38
9.1CRP, F2
3
Show member pathways
8.5F3, SERPINC1, F2
4
Show member pathways
8.5F2, SERPINC1, F3
5
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
8.5F3, SERPINC1, F2
6
Show member pathways
8.5F3, SERPINC1, F2

Compounds for genes affiliated with Peripheral Vertigo

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Sources:
45Novoseek, 11DrugBank, 24HMDB, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR, 3BitterDB
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Compounds related to Peripheral Vertigo according to GeneCards/GeneDecks:

(show top 50)    (show all 120)
idCompoundScoreTop Affiliating Genes
1celite459.5SERPINC1, F3
2aprosulate459.3F3, F2
3napsagatran459.2F2, F3
4brodifacoum459.2F2, F3
5ticlopidine45 1110.2APOH, SERPINC1, F3
6mnpt459.1F2, F3
7kaolin459.1APOH, F2, F3
8coumarins459.0F3, APOH, F2
9certoparin459.0F3, F2, SERPINC1
10inogatran458.9F2, F3, SERPINC1
11ecarin458.9F3, SERPINC1, F2
12spectrozyme458.9SERPINC1, F3, F2
13polybrene458.9F3, SERPINC1, F2
14hepaplastin458.9F2, SERPINC1, F3
15danaparoid458.9F3, F2, SERPINC1
16organon458.9F3, SERPINC1, F2
17ximelagatran45 119.9F2, SERPINC1, F3
18rivaroxaban45 119.9F3, SERPINC1, F2
19vitamin k145 249.9F3, SERPINC1, F2
20cardiolipin45 119.9F3, F2, APOH
21heparinoids458.9F3, F2, SERPINC1
22fondaparinux458.9SERPINC1, F3, F2
23bivalirudin45 119.9F3, SERPINC1, F2
24hydroxyethyl starch458.9SERPINC1, F3, F2
25dextran sulfate458.9F3, SERPINC1, APOH
26argatroban45 119.9F2, SERPINC1, F3
27phenprocoumon45 51 1110.9F2, SERPINC1, F3
28ppack458.9F2, F3, SERPINC1
29protamine sulfate458.9F2, F3, SERPINC1
30tranexamic acid45 119.8F2, F3, SERPINC1
31epsilon aminocaproic acid458.8F2, F3, SERPINC1
32ristocetin458.8F3, SERPINC1, F2
33levonorgestrel45 61 29 1111.8F2, F3, SERPINC1
34desmopressin45 61 29 1111.8F2, SERPINC1, F3
35coumarin45 3 51 2411.8F3, SERPINC1, F2
36hirudin458.7SERPINC1, F2, F3
37prostacyclin458.6CRP, SERPINC1, APOH, F3
38warfarin45 51 24 1111.5F2, APOH, SERPINC1, F3
39kininogen458.5SERPINC1, F3, APOH, F2
40tirofiban45 119.4SERPINC1, F2, F3, CRP
41abciximab45 119.4CRP, F3, F2, SERPINC1
42clopidogrel45 51 24 1111.4F2, SERPINC1, CRP, F3
43protamine458.4F3, F2, SERPINC1
44citrate458.3CRP, F2, SERPINC1, F3
45dermatan sulfate458.2SERPINC1, F2, F3
46homocysteine45 249.0F3, F2, SERPINC1, APOH, CRP
47aspirin45 51 29 2411.0F2, SERPINC1, F3, APOH, CRP
48fibrinogen457.9CRP, APOH, F3, SERPINC1, F2
49alanine457.8CRP, GAD1, F2, SERPINC1, F3
50creatinine457.6GAD1, F2, APOH, SERPINC1, F3, CRP

GO Terms for genes affiliated with Peripheral Vertigo

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16Gene Ontology
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Cellular components related to Peripheral Vertigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.0SERPINC1, F2
2extracellular spaceGO:0056157.2CRP, F3, SERPINC1, APOH, F2

Biological processes related to Peripheral Vertigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of fibrinolysisGO:0519189.3APOH, F2
2positive regulation of blood coagulationGO:0301949.2APOH, F2
3blood coagulation, intrinsic pathwayGO:0075979.1F2, APOH
4acute-phase responseGO:0069538.8CRP, F2
5blood coagulationGO:0075968.5F3, SERPINC1, F2

Molecular functions related to Peripheral Vertigo according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipid bindingGO:0055439.5F3, APOH
2protease bindingGO:0020209.0F3, SERPINC1
3protein bindingGO:0055157.0SERPINC1, F2, GAD1, CRP, F3, APOH

Products for genes affiliated with Peripheral Vertigo

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  • Antibodies
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Sources for Peripheral Vertigo

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet