MCID: PRT070
MIFTS: 37

Peritoneal Carcinoma malady

Cancer diseases category

Summaries for Peritoneal Carcinoma

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32MalaCards
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MalaCards: Peritoneal Carcinoma, also known as malignant tumor of peritoneum, is related to peritonitis and ovarian cancer. An important gene associated with Peritoneal Carcinoma is CXCL10 (chemokine (C-X-C motif) ligand 10), and among its related pathways are TGF-Beta Pathway and DNA damage DNA-damage-induced responses. The compounds cycloheximide and adriamycin have been mentioned in the context of this disorder. Related mouse phenotypes are limbs/digits/tail and muscle.

Aliases & Classifications for Peritoneal Carcinoma

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10DISEASES, 44Novoseek, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

peritoneal carcinoma 10
malignant tumor of peritoneum 60
carcinoma of peritoneum 60
peritoneal cancer 44


Related Diseases for Peritoneal Carcinoma

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17GeneCards, 18GeneDecks
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Diseases in the Primary Peritoneal Carcinoma family:

Peritoneal Benign Neoplasm peritoneal carcinoma

Diseases related to Peritoneal Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 169)
idRelated DiseaseScoreTop Affiliating Genes
1peritonitis31.5MUC16
2ovarian cancer30.5BRCA1, BRCA2, EGFR, MUC16, PGR, ERCC1
3fallopian tube cancer30.4BRCA1, BRCA2
4papillary carcinoma30.2ERBB2, PGR, RET, MUC16, BRCA2
5adenocarcinoma30.2BRCA1, BRCA2, EGFR, MUC16, PGR, CXCL10
6lynch syndrome30.1BRCA1, BRCA2
7cervical adenocarcinoma29.9MUC16, PGR, CEACAM5
8endometriosis29.9IL8, PGR, MUC16
9brain cancer29.8EGFR, TP53
10ovarian disease10.3
11primary peritoneal carcinoma10.3
12peritoneum cancer10.2
13retroperitoneal cancer10.2
14peritoneal serous papillary adenocarcinoma10.1
15tuberculosis10.1
16cystadenoma10.0BRCA1
17herpes simplex10.0CXCL10
18pleurisy10.0MUC16
19colon adenocarcinoma10.0CEACAM5
20wilms tumor10.0BRCA2
21leiomyoma10.0PGR
22meningioma10.0PGR
23uterine carcinosarcoma10.0ERBB2
24biliary atresia10.0CXCL10
25arthropathy10.0CXCL10
26dermatomyositis10.0MUC16
27neurofibromatosis10.0RET
28severe acute respiratory syndrome10.0CXCL10
29angiomyolipoma10.0PGR
30breast-ovarian cancer, familial, 210.0BRCA2
31hepatitis10.0CXCL10
32mycosis fungoides10.0CXCL10
33hemangioma10.0RET
34von hippel-lindau disease10.0RET
35parathyroid carcinoma10.0RET
36pulmonary fibrosis10.0IL8
37hyperparathyroidism10.0RET
38papilloma10.0TP53
39connective tissue disease10.0IL10
40osteosarcoma10.0TP53
41toxic shock syndrome10.0IFNG
42galactosemia10.0IL10
43ependymoma10.0EGFR
44alopecia areata10.0IFNG
45rhabdomyosarcoma10.0TP53
46anaplastic large cell lymphoma10.0MUC16
47rhinitis10.0IL8
48multiple myeloma10.0TP53
49peutz-jeghers syndrome10.0BRCA2
50oral cavity cancer10.0TP53

Graphical network of the top 20 diseases related to Peritoneal Carcinoma:



Diseases related to peritoneal carcinoma

Clinical Features for Peritoneal Carcinoma

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Drugs & Therapeutics for Peritoneal Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Peritoneal Carcinoma

Drug clinical trials:

Search ClinicalTrials for Peritoneal Carcinoma

Search NIH Clinical Center for Peritoneal Carcinoma

Search CenterWatch for Peritoneal Carcinoma

Genetic Tests for Peritoneal Carcinoma

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Anatomical Context for Peritoneal Carcinoma

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Animal Models for Peritoneal Carcinoma or affiliated genes

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36MGI
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Publications for Peritoneal Carcinoma

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Genetic Variations for Peritoneal Carcinoma

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Expression for genes affiliated with Peritoneal Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Peritoneal Carcinoma

Search GEO for disease gene expression data for Peritoneal Carcinoma.

Pathways for genes affiliated with Peritoneal Carcinoma

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Sources:
51QIAGEN, 12EMD Millipore, 59Tocris Bioscience, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems, 55SinoBiological
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Pathways related to Peritoneal Carcinoma according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3ERBB2
210.1BRCA1, TP53
3
Hide members
10.1TP53, ERBB2
410.0BRCA2, BRCA1, ERCC1
510.0MIR497, MIR195
69.9TP53, BRCA2, BRCA1
7
DNA damage Role of Brca1 and Brca2 in DNA repair
Hide members
9.9TP53, BRCA2, BRCA1
89.9IL8, BRCA1, IFNG
99.9EGFR, CXCL10, TP53
109.9IL8, IL10, IFNG
119.9IL8, TP53, IFNG
129.8EGFR, ERBB2, TP53
139.8TP53, ERBB2, EGFR
14
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9.7BRCA1, TP53, CXCL10, ERBB2
15
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9.7BRCA2, TP53, IL8, BRCA1
169.7BRCA1, BRCA2, TP53, EGFR
17
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9.7EGFR, CXCL10, ERBB2, TP53
18
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9.7BRCA2, TP53, ERBB2, EGFR
199.5TP53, ERBB2, EGFR, BRCA2, BRCA1
20
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9.5IFNG, TP53, IL8, IL10, CXCL10
219.4MIR195, TP53, BRCA1, ERBB2, EGFR
22
Hide members
9.3EGFR, IL8, CXCL10, ERBB2, TP53, IL10
239.2BRCA2, EGFR, RET, TP53, ERBB2, IL8

Compounds for genes affiliated with Peritoneal Carcinoma

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Peritoneal Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 123)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.4CXCL10, BRCA1, BRCA2
2adriamycin4410.4PGR, CEACAM5
3dexamethasone44 49 28 1113.3MUC16
4resveratrol44 59 11 2413.3PGR, ERBB2, BRCA2
5tamoxifen44 49 28 1113.2ERBB2, EGFR, PGR
6vinorelbine44 1111.1ERBB2, ERCC1, EGFR, BRCA1
7fluticasone propionate44 49 59 1113.1IL8, IFNG, PGR, CXCL10
8polyinosinic-polycytidylic acid4410.1IL8, IL10, CXCL10, IFNG
9taxane4410.0EGFR, PGR, TP53, ERBB2
10anastrozole44 1111.0PGR, EGFR, ERBB2
11il 104410.0IL8, IL10, CXCL10, IFNG
12tarc4410.0IL8, IL10, CXCL10, IFNG
13ccl344 2811.0IL8, CXCL10, IFNG, IL10
14suberoylanilide hydroxamic acid449.9TP53, EGFR, IFNG, ERBB2
15leucovorin44 49 1111.9CEACAM5, PGR, ERBB2, EGFR
16gold449.9CXCL10, MUC16, BRCA2, CEACAM5
17neopterin449.9IL8, IL10, CXCL10, IFNG
18hydrocortisone44 2 59 1112.9IFNG, ERBB2, CXCL10, IL10, IL8
19capecitabine44 49 1111.9PGR, ERBB2, EGFR
20irinotecan44 49 1111.8CEACAM5, ERBB2, ERCC1, EGFR, TP53
21melphalan44 1110.8ERCC1, TP53, MUC16, IFNG
22methotrexate44 49 1111.8ERCC1, ERBB2, IL10, PGR, BRCA2, BRCA1
23exemestane49 44 59 1112.8PGR, ERBB2, EGFR
24topotecan44 1110.8EGFR, ERBB2, TP53, MUC16, BRCA1
254-hydroxytamoxifen449.8EGFR, PGR, ERBB2, IFNG, BRCA2, BRCA1
26bortezomib44 1110.7TP53, EGFR, BRCA1, ERBB2
27gemcitabine44 49 1111.7IL10, ERBB2, EGFR, BRCA1, ERCC1, TP53
28thymidylate449.7EGFR, BRCA1, IL10, ERCC1, ERBB2, TP53
29adpribose449.7BRCA1, TP53, BRCA2, EGFR
30mitomycin c449.7TP53, BRCA1, BRCA2, IL10, ERCC1, CEACAM5
31oxaliplatin44 49 1111.7BRCA1, CEACAM5, TP53, EGFR, ERBB2, ERCC1
32herbimycin a44 5910.6ERBB2, RET, EGFR, IFNG, IL8
33docetaxel44 49 59 1112.6EGFR, BRCA2, PGR, ERBB2, TP53, BRCA1
34lapatinib44 49 1111.6PGR, EGFR, ERBB2
35cyclophosphamide44 49 1111.5ERCC1, TP53, IL10, ERBB2, PGR, MUC16
36agar449.5CEACAM5, BRCA1, EGFR, RET, PGR, ERBB2
37carboplatin44 49 1111.4ERCC1, IFNG, BRCA1, EGFR, MUC16, ERBB2
38ly294002449.4RET, EGFR, IL10, IL8, ERBB2, TP53
39thymidine44 2410.3IL10, ERCC1, CEACAM5, TP53, CXCL10, IFNG
40paclitaxel44 49 1111.3TP53, ERBB2, PGR, MUC16, EGFR, BRCA2
415fluorouracil449.3CEACAM5, IFNG, EGFR, PGR, BRCA1, ERCC1
42doxorubicin44 49 1111.2EGFR, TP53, MUC16, CEACAM5, PGR, ERCC1
43phosphatidylinositol449.2BRCA2, ERCC1, BRCA1, CEACAM5, EGFR, CXCL10
44testosterone44 59 11 2412.2RET, PGR, MUC16, EGFR, BRCA2, ERBB2
45cisplatin44 49 59 1112.2ERCC1, MUC16, EGFR, ERBB2, TP53, CEACAM5
46genistein44 28 59 2 11 2414.1PGR, CXCL10, RET, IFNG, BRCA2, BRCA1
47retinoic acid44 2410.0TP53, CXCL10, PGR, RET, BRCA2, EGFR
48progesterone44 59 28 11 2413.0MUC16, ERBB2, PGR, TP53, EGFR, BRCA2
49paraffin448.7IL10, CEACAM5, ERBB2, BRCA1, PGR, RET
50vegf448.1EGFR, ERCC1, IL10, CXCL10, PGR, RET

GO Terms for genes affiliated with Peritoneal Carcinoma

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16Gene Ontology
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Cellular components related to Peritoneal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.2IL8, IL10, CXCL10, MUC16, EGFR, IFNG

Biological processes related to Peritoneal Carcinoma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:04534810.2IL10, IFNG
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.2BRCA1, TP53, BRCA2
3response to X-rayGO:01016510.1ERCC1, TP53, BRCA2
4response to gamma radiationGO:01033210.1BRCA2, CXCL10, TP53
5double-strand break repairGO:00630210.0BRCA2, BRCA1, TP53, ERCC1
6nucleotide-excision repairGO:00628910.0TP53, ERCC1, BRCA2
7cellular response to lipopolysaccharideGO:07122210.0IL8, IL10, IFNG
8response to molecule of bacterial originGO:00223710.0IL10, IL8
9UV protectionGO:0096509.9SCARA3, ERCC1
10cell surface receptor signaling pathwayGO:0071669.9ERBB2, CXCL10, EGFR, IFNG
11positive regulation of transcription, DNA-dependentGO:0458939.4TP53, BRCA1, BRCA2, RET, IL10
12signal transductionGO:0071658.9EGFR, ERBB2, IL8, CXCL10, PGR, RET

Molecular functions related to Peritoneal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:00500610.1EGFR, ERBB2
2transmembrane receptor protein tyrosine kinase activityGO:0047149.8ERBB2, RET, EGFR
3receptor signaling protein tyrosine kinase activityGO:0047169.8EGFR, ERBB2
4protein tyrosine kinase activityGO:0047139.7EGFR, RET, ERBB2
5enzyme bindingGO:0198999.6BRCA1, EGFR, PGR, TP53

Products for genes affiliated with Peritoneal Carcinoma

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Peritoneal Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet