MCID: PRT070
MIFTS: 37

Peritoneal Carcinoma malady

Cancer diseases category

Summaries for Peritoneal Carcinoma

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Peritoneal Carcinoma, also known as malignant tumor of peritoneum, is related to peritonitis and ovarian cancer. An important gene associated with Peritoneal Carcinoma is CXCL10 (chemokine (C-X-C motif) ligand 10), and among its related pathways are TGF-Beta Pathway and DNA damage DNA-damage-induced responses. The compounds cycloheximide and adriamycin have been mentioned in the context of this disorder. Related mouse phenotypes are limbs/digits/tail and muscle.

Aliases & Classifications for Peritoneal Carcinoma

About this section
Sources:
10DISEASES, 44Novoseek, 60UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

peritoneal carcinoma 10
malignant tumor of peritoneum 60
carcinoma of peritoneum 60
peritoneal cancer 44


Related Diseases for Peritoneal Carcinoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Primary Peritoneal Carcinoma family:

Peritoneal Benign Neoplasm peritoneal carcinoma

Diseases related to Peritoneal Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 169)
idRelated DiseaseScoreTop Affiliating Genes
1peritonitis31.5MUC16
2ovarian cancer30.5BRCA1, BRCA2, EGFR, MUC16, PGR, ERCC1
3fallopian tube cancer30.4BRCA1, BRCA2
4papillary carcinoma30.2ERBB2, PGR, RET, MUC16, BRCA2
5adenocarcinoma30.2BRCA1, BRCA2, EGFR, MUC16, PGR, CXCL10
6lynch syndrome30.1BRCA1, BRCA2
7cervical adenocarcinoma29.9MUC16, PGR, CEACAM5
8endometriosis29.9IL8, PGR, MUC16
9brain cancer29.8EGFR, TP53
10ovarian disease10.3
11primary peritoneal carcinoma10.3
12peritoneum cancer10.2
13retroperitoneal cancer10.2
14peritoneal serous papillary adenocarcinoma10.1
15tuberculosis10.1
16cystadenoma10.0BRCA1
17herpes simplex10.0CXCL10
18pleurisy10.0MUC16
19colon adenocarcinoma10.0CEACAM5
20wilms tumor10.0BRCA2
21leiomyoma10.0PGR
22meningioma10.0PGR
23uterine carcinosarcoma10.0ERBB2
24biliary atresia10.0CXCL10
25arthropathy10.0CXCL10
26dermatomyositis10.0MUC16
27neurofibromatosis10.0RET
28severe acute respiratory syndrome10.0CXCL10
29angiomyolipoma10.0PGR
30breast-ovarian cancer, familial, 210.0BRCA2
31hepatitis10.0CXCL10
32mycosis fungoides10.0CXCL10
33hemangioma10.0RET
34von hippel-lindau disease10.0RET
35parathyroid carcinoma10.0RET
36pulmonary fibrosis10.0IL8
37hyperparathyroidism10.0RET
38papilloma10.0TP53
39connective tissue disease10.0IL10
40osteosarcoma10.0TP53
41toxic shock syndrome10.0IFNG
42galactosemia10.0IL10
43ependymoma10.0EGFR
44alopecia areata10.0IFNG
45rhabdomyosarcoma10.0TP53
46anaplastic large cell lymphoma10.0MUC16
47rhinitis10.0IL8
48multiple myeloma10.0TP53
49peutz-jeghers syndrome10.0BRCA2
50oral cavity cancer10.0TP53

Graphical network of the top 20 diseases related to Peritoneal Carcinoma:



Diseases related to peritoneal carcinoma

Clinical Features for Peritoneal Carcinoma

About this section

Drugs & Therapeutics for Peritoneal Carcinoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Peritoneal Carcinoma

Drug clinical trials:

Search ClinicalTrials for Peritoneal Carcinoma

Search NIH Clinical Center for Peritoneal Carcinoma

Search CenterWatch for Peritoneal Carcinoma

Genetic Tests for Peritoneal Carcinoma

About this section

Anatomical Context for Peritoneal Carcinoma

About this section

Animal Models for Peritoneal Carcinoma or affiliated genes

About this section
Sources:
36MGI
See all sources

Publications for Peritoneal Carcinoma

About this section

Genetic Variations for Peritoneal Carcinoma

About this section

Expression for genes affiliated with Peritoneal Carcinoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Peritoneal Carcinoma

Search GEO for disease gene expression data for Peritoneal Carcinoma.

Pathways for genes affiliated with Peritoneal Carcinoma

About this section
Sources:
51QIAGEN, 12EMD Millipore, 59Tocris Bioscience, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems, 55SinoBiological
See all sources

Pathways related to Peritoneal Carcinoma according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3ERBB2
210.1TP53, BRCA1
3
Hide members
10.1TP53, ERBB2
410.0ERCC1, BRCA2, BRCA1
510.0MIR195, MIR497
69.9TP53, BRCA2, BRCA1
7
DNA damage Role of Brca1 and Brca2 in DNA repair
Hide members
9.9TP53, BRCA2, BRCA1
89.9BRCA1, IFNG, IL8
99.9EGFR, CXCL10, TP53
109.9IL8, IL10, IFNG
119.9TP53, IL8, IFNG
129.8EGFR, ERBB2, TP53
139.8EGFR, ERBB2, TP53
14
Hide members
9.7BRCA1, CXCL10, ERBB2, TP53
15
Hide members
9.7TP53, IL8, BRCA2, BRCA1
169.7BRCA1, BRCA2, EGFR, TP53
17
Hide members
9.7EGFR, CXCL10, ERBB2, TP53
18
Hide members
9.7TP53, ERBB2, EGFR, BRCA2
199.5BRCA1, BRCA2, EGFR, ERBB2, TP53
20
Hide members
9.5IFNG, CXCL10, IL10, IL8, TP53
219.4BRCA1, EGFR, MIR195, ERBB2, TP53
22
Hide members
9.3EGFR, CXCL10, IL10, IL8, ERBB2, TP53
239.2BRCA2, EGFR, RET, IL8, ERBB2, TP53

Compounds for genes affiliated with Peritoneal Carcinoma

About this section
Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 24HMDB, 2BitterDB
See all sources

Compounds related to Peritoneal Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 123)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.4BRCA2, BRCA1, CXCL10
2adriamycin4410.4PGR, CEACAM5
3dexamethasone44 49 28 1113.3MUC16
4resveratrol44 59 11 2413.3ERBB2, BRCA2, PGR
5tamoxifen44 49 28 1113.2EGFR, PGR, ERBB2
6vinorelbine44 1111.1ERBB2, ERCC1, EGFR, BRCA1
7fluticasone propionate44 49 59 1113.1IL8, IFNG, PGR, CXCL10
8polyinosinic-polycytidylic acid4410.1IFNG, CXCL10, IL10, IL8
9taxane4410.0EGFR, PGR, TP53, ERBB2
10anastrozole44 1111.0ERBB2, EGFR, PGR
11il 104410.0IFNG, IL10, CXCL10, IL8
12tarc4410.0IL8, IL10, CXCL10, IFNG
13ccl344 2811.0CXCL10, IL8, IL10, IFNG
14suberoylanilide hydroxamic acid449.9IFNG, TP53, ERBB2, EGFR
15leucovorin44 49 1111.9ERBB2, EGFR, CEACAM5, PGR
16gold449.9BRCA2, MUC16, CXCL10, CEACAM5
17neopterin449.9IL10, CXCL10, IL8, IFNG
18hydrocortisone44 2 59 1112.9ERBB2, CXCL10, IL10, IL8, IFNG
19capecitabine44 49 1111.9EGFR, PGR, ERBB2
20etoposide44 49 59 1112.8ERBB2, ERCC1, BRCA2, BRCA1
21irinotecan44 49 1111.8ERCC1, ERBB2, CEACAM5, TP53, EGFR
22melphalan44 1110.8ERCC1, IFNG, MUC16, TP53
23methotrexate44 49 1111.8ERBB2, BRCA1, BRCA2, ERCC1, PGR, IL10
24exemestane49 44 59 1112.8PGR, EGFR, ERBB2
25topotecan44 1110.8TP53, EGFR, BRCA1, MUC16, ERBB2
264-hydroxytamoxifen449.8ERBB2, PGR, EGFR, BRCA1, BRCA2, IFNG
27bortezomib44 1110.7TP53, ERBB2, BRCA1, EGFR
28gemcitabine44 49 1111.7ERBB2, TP53, ERCC1, IL10, BRCA1, EGFR
29thymidylate449.7BRCA1, TP53, ERBB2, ERCC1, IL10, EGFR
30mitomycin c449.7BRCA2, TP53, CEACAM5, ERCC1, IL10, BRCA1
31oxaliplatin44 49 1111.7EGFR, TP53, ERCC1, ERBB2, BRCA1, CEACAM5
32herbimycin a44 5910.6IFNG, EGFR, RET, IL8, ERBB2
33docetaxel44 49 59 1112.6TP53, ERBB2, BRCA2, PGR, BRCA1, EGFR
34lapatinib44 49 1111.6PGR, ERBB2, EGFR
35cyclophosphamide44 49 1111.5ERCC1, ERBB2, TP53, IL10, MUC16, BRCA1
36agar449.5BRCA1, EGFR, RET, PGR, CEACAM5, ERBB2
37carboplatin44 49 1111.4TP53, ERBB2, ERCC1, BRCA1, IFNG, EGFR
38ly294002449.4RET, IL10, IL8, ERBB2, TP53, EGFR
39thymidine44 2410.3TP53, CEACAM5, ERCC1, IL10, BRCA1, BRCA2
40paclitaxel44 49 1111.3PGR, BRCA1, BRCA2, EGFR, MUC16, TP53
415fluorouracil449.3BRCA1, ERBB2, IFNG, PGR, ERCC1, CEACAM5
42doxorubicin44 49 1111.2MUC16, BRCA1, TP53, ERCC1, ERBB2, CEACAM5
43phosphatidylinositol449.2BRCA1, EGFR, BRCA2, CXCL10, RET, ERBB2
44testosterone44 59 11 2412.2ERBB2, PGR, RET, MUC16, EGFR, BRCA2
45cisplatin44 49 59 1112.2ERCC1, CEACAM5, TP53, BRCA1, BRCA2, EGFR
46genistein44 28 59 2 11 2414.1BRCA1, IL8, CXCL10, PGR, RET, EGFR
47retinoic acid44 2410.0TP53, PGR, CXCL10, EGFR, IFNG, BRCA1
48progesterone44 59 28 11 2413.0PGR, TP53, ERBB2, CXCL10, CEACAM5, BRCA1
49paraffin448.7TP53, IL10, MUC16, CEACAM5, BRCA1, ERBB2
50vegf448.1BRCA1, IFNG, MUC16, RET, PGR, CXCL10

GO Terms for genes affiliated with Peritoneal Carcinoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Peritoneal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.2IL8, IL10, CXCL10, MUC16, EGFR, IFNG

Biological processes related to Peritoneal Carcinoma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:04534810.2IFNG, IL10
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.2BRCA1, BRCA2, TP53
3response to X-rayGO:01016510.1TP53, ERCC1, BRCA2
4response to gamma radiationGO:01033210.1BRCA2, CXCL10, TP53
5double-strand break repairGO:00630210.0TP53, ERCC1, BRCA2, BRCA1
6nucleotide-excision repairGO:00628910.0BRCA2, ERCC1, TP53
7cellular response to lipopolysaccharideGO:07122210.0IFNG, IL10, IL8
8response to molecule of bacterial originGO:00223710.0IL10, IL8
9UV protectionGO:0096509.9ERCC1, SCARA3
10cell surface receptor signaling pathwayGO:0071669.9ERBB2, CXCL10, EGFR, IFNG
11positive regulation of transcription, DNA-dependentGO:0458939.4TP53, IL10, RET, BRCA2, BRCA1
12signal transductionGO:0071658.9ERBB2, IL8, CXCL10, PGR, RET, EGFR

Molecular functions related to Peritoneal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:00500610.1ERBB2, EGFR
2transmembrane receptor protein tyrosine kinase activityGO:0047149.8ERBB2, RET, EGFR
3receptor signaling protein tyrosine kinase activityGO:0047169.8ERBB2, EGFR
4protein tyrosine kinase activityGO:0047139.7ERBB2, RET, EGFR
5enzyme bindingGO:0198999.6BRCA1, EGFR, PGR, TP53

Products for genes affiliated with Peritoneal Carcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Peritoneal Carcinoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet