MCID: PRT070
MIFTS: 45

Peritoneal Carcinoma malady

Cancer diseases, Rare diseases categories

Summaries for Peritoneal Carcinoma

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34MalaCards
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MalaCards: Peritoneal Carcinoma, also known as malignant tumor of peritoneum, is related to ovarian cancer and adenocarcinoma. An important gene associated with Peritoneal Carcinoma is CXCL10 (chemokine (C-X-C motif) ligand 10), and among its related pathways are Meiosis and Fanconi anemia pathway. The compounds 8-oxoguanine and daidzein have been mentioned in the context of this disorder. Affiliated tissues include lymph node, breast and brain, and related mouse phenotypes are limbs/digits/tail and digestive/alimentary.

Aliases & Classifications for Peritoneal Carcinoma

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11DISEASES, 46Novoseek, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases


Aliases & Descriptions:

peritoneal carcinoma 11
malignant tumor of peritoneum 63
carcinoma of peritoneum 63
peritoneal cancer 46


Related Diseases for Peritoneal Carcinoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Primary Peritoneal Carcinoma family:

Peritoneal Benign Neoplasm peritoneal carcinoma

Diseases related to Peritoneal Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1ovarian cancer30.5ERCC1, BRCA1, BRCA2
2adenocarcinoma30.2BRCA2, BRCA1, CXCL10, ERCC1
3lynch syndrome30.2BRCA1, BRCA2
4fallopian tube cancer29.9BRCA2, BRCA1
5peritonitis11.0
6primary peritoneal carcinoma11.0
7tuberculosis10.1
8breast-ovarian cancer, familial, 210.1BRCA2
9brca1 and brca2 hereditary breast and ovarian cancer10.0BRCA2, BRCA1
10bilateral breast cancer10.0BRCA2, BRCA1
11male breast cancer10.0BRCA1, BRCA2
12dysgerminoma10.0BRCA1, BRCA2
13gynecomastia10.0BRCA1, BRCA2
14ductal carcinoma in situ10.0BRCA1, BRCA2
15bloom syndrome10.0BRCA2, BRCA1
16li-fraumeni syndrome10.0BRCA2, BRCA1
17aplastic anemia10.0BRCA2, BRCA1
18xeroderma pigmentosum10.0ERCC1, BRCA1
19fanconi's anemia10.0BRCA1, BRCA2
20multiple endocrine neoplasia10.0BRCA2, RET
21neurofibromatosis10.0RET, BRCA2
22autosomal dominant disease10.0RET, BRCA1
23ataxia telangiectasia10.0BRCA1, BRCA2
24papillary carcinoma10.0BRCA2, RET
25endometrial carcinoma10.0BRCA1, BRCA2
26bladder carcinoma10.0ERCC1, CXCL10, BRCA1
27pancreatic cancer10.0RET, BRCA2
28astrocytoma10.0ERCC1, CXCL10, BRCA1
29hodgkin's lymphoma10.0BRCA1, BRCA2
30chronic lymphocytic leukemia10.0BRCA2, ERCC1
31stomach cancer10.0BRCA2, BRCA1, ERCC1
32lymphangitis10.0
33choroiditis10.0
34cervicitis10.0
35endometriosis10.0
36in situ carcinoma10.0
37paraneoplastic syndromes10.0
38endotheliitis10.0
39intestinal lymphangiectasia10.0
40breast cancer10.0BRCA2, BRCA1, ERCC1
41colon cancer10.0ERCC1, BRCA1, BRCA2
42melanoma10.0BRCA2, CXCL10, ERCC1
43colorectal cancer10.0BRCA2, BRCA1, ERCC1
44familial colorectal cancer10.0BRCA2, BRCA1, RET
45cowden disease10.0RET, BRCA1, BRCA2
46adenoma9.9ERCC1, RET, BRCA1
47prostate cancer9.9BRCA2, BRCA1, CXCL10, ERCC1
48newcastle disease9.9
49asbestosis9.9
50liver cirrhosis9.9

Graphical network of the top 20 diseases related to Peritoneal Carcinoma:



Diseases related to peritoneal carcinoma

Symptoms for Peritoneal Carcinoma

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Drugs & Therapeutics for Peritoneal Carcinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Peritoneal Carcinoma

Drug clinical trials:

Search ClinicalTrials for Peritoneal Carcinoma

Search NIH Clinical Center for Peritoneal Carcinoma

Search CenterWatch for Peritoneal Carcinoma

Genetic Tests for Peritoneal Carcinoma

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Anatomical Context for Peritoneal Carcinoma

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34MalaCards
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MalaCards organs/tissues related to Peritoneal Carcinoma:

34
Lymph node, Breast, Brain, Ovary, Eye, Testes, Endothelial

Animal Models for Peritoneal Carcinoma or affiliated genes

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38MGI
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Publications for Peritoneal Carcinoma

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53PubMed
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Articles related to Peritoneal Carcinoma:

(show top 50)    (show all 142)
idTitleAuthorsYear
1
A phase II study of modified dose-dense paclitaxel and every 4-week carboplatin for the treatment of advanced-stage primary epithelial ovarian, fallopian tube, or peritoneal carcinoma. (23660691)
2013
2
Pegylated liposomal doxorubicin for platinum-resistant or refractory MA1llerian carcinoma (epithelial ovarian carcinoma, primary carcinoma of Fallopian tube and peritoneal carcinoma): A single-institutional experience. (23255889)
2013
3
Association between Rash and a Positive Drug Response Associated with Vinorelbine in a Patient with Primary Peritoneal Carcinoma. (24073344)
2013
4
Upper abdominal procedures in advanced stage ovarian or primary peritoneal carcinoma patients with minimal or no gross residual disease: an analysis of Gynecologic Oncology Group (GOG) 182. (23791702)
2013
5
A phase II trial of Sunitinib malate in recurrent and refractory ovarian, fallopian tube and peritoneal carcinoma. (22885865)
2013
6
The effect of age on first-line chemotherapy for epithelial ovarian cancer and primary peritoneal carcinoma. (23146339)
2013
7
Phase II evaluation of dasatinib in the treatment of recurrent or persistent epithelial ovarian or primary peritoneal carcinoma: a Gynecologic Oncology Group study. (22710075)
2012
8
A phase II study of a urokinase-derived peptide (A6) in the treatment of persistent or recurrent epithelial ovarian, fallopian tube, or primary peritoneal carcinoma: a Gynecologic Oncology Group study. (22446624)
2012
9
A phase II evaluation of lapatinib in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: a gynecologic oncology group study. (22037316)
2012
10
Prognosis of primary peritoneal carcinoma: effect of cytoreductive surgery combined with neoadjuvant chemotherapy after laparoscopic diagnosis and evaluation: a multi-center trial. (22439406)
2012
11
Intravenous/intraperitoneal paclitaxel and intraperitoneal carboplatin in patients with epithelial ovarian, fallopian tube, or peritoneal carcinoma: a feasibility study. (22146766)
2012
12
An analysis of patients with bulky advanced stage ovarian, tubal, and peritoneal carcinoma treated with primary debulking surgery (PDS) during an identical time period as the randomized EORTC-NCIC trial of PDS vs neoadjuvant chemotherapy (NACT). (21917306)
2012
13
Primary peritoneal carcinoma in complete remission: a case report. (22199305)
2011
14
Peritoneal tuberculosis: a retrospective review of 20 cases and comparison with primary peritoneal carcinoma. (20973271)
2010
15
Methylation and protein expression of DNA repair genes: association with chemotherapy exposure and survival in sporadic ovarian and peritoneal carcinomas. (19602291)
2009
16
Phase II trial of single agent cetuximab in patients with persistent or recurrent epithelial ovarian or primary peritoneal carcinoma with the potential for dose escalation to rash. (19162309)
2009
17
A contemporary analysis of the ability of preoperative serum CA-125 to predict primary cytoreductive outcome in patients with advanced ovarian, tubal and peritoneal carcinoma. (19100916)
2009
18
RET/PTC rearrangement occurring in primary peritoneal carcinoma. (19147513)
2009
19
Primary peritoneal carcinoma: computed tomography and magnetic resonance findings. (18664839)
2008
20
Advanced primary peritoneal carcinoma: clinicopathological and prognostic factor analyses. (18543395)
2008
21
Paclitaxel, carboplatin and pegylated liposomal doxorubicin in ovarian and peritoneal carcinoma: a phase I study of the Gynecologic Oncology Group. (16959305)
2007
22
Common polymorphisms in TP53 and MDM2 and the relationship to TP53 mutations and clinical outcomes in women with ovarian and peritoneal carcinomas. (17171684)
2007
23
Colorectal resection in patients with ovarian and primary peritoneal carcinoma. (16730631)
2006
24
Primary peritoneal carcinoma in a UK cancer center: comparison with advanced ovarian carcinoma over a 5-year period. (16515579)
2006
25
Common polymorphism in interleukin 6 influences survival of women with ovarian and peritoneal carcinoma. (17023036)
2006
26
Primary peritoneal carcinoma: a rare neoplasm with pleomorphic trophoblastic morphology. (16907865)
2006
27
Safety and efficacy of thalidomide in recurrent epithelial ovarian and peritoneal carcinoma. (16828852)
2006
28
Phase II evaluation of 9-aminocamptothecin (9-AC, NSC #603071) in platinum-resistant ovarian and primary peritoneal carcinoma: a Gynecologic Oncology Group Study. (15589582)
2005
29
Is semen an etiologic factor in the development of primary peritoneal carcinoma and epithelial ovarian cancer? (15607552)
2005
30
Weekly carboplatin in a frail elderly woman with advanced peritoneal carcinoma. (16001195)
2005
31
A phase I/II trial of weekly topotecan and carboplatin in potentially platinum-sensitive relapsed ovarian and peritoneal carcinoma. (16112177)
2005
32
Gemcitabine and cisplatin chemotherapy is an active combination in the treatment of platinum-resistant ovarian and peritoneal carcinoma. (15292718)
2004
33
Peritoneal carcinoma in women with genetic susceptibility: implications for Jewish populations. (15516851)
2004
34
Peritoneal carcinoma in a male patient. (12759547)
2003
35
A phase II study of docetaxel in paclitaxel-resistant ovarian and peritoneal carcinoma: a Gynecologic Oncology Group study. (12586591)
2003
36
Gemcitabine reverses cisplatin resistance: demonstration of activity in platinum- and multidrug-resistant ovarian and peritoneal carcinoma. (12504621)
2003
37
Fallopian tube and primary peritoneal carcinomas associated with BRCA mutations. (14615451)
2003
38
Axillary lymphadenopathy as the primary presentation of primary peritoneal carcinoma. (12592068)
2002
39
Positive emission tomography for evaluating a complete clinical response in patients with ovarian or peritoneal carcinoma: correlation with second-look laparotomy. (11426956)
2001
40
Extreme drug resistance assay and response to chemotherapy in patients with primary peritoneal carcinoma. (10738268)
2000
41
Clinical and biological effects of intraperitoneal injections of recombinant interferon-gamma and recombinant interleukin 2 with or without tumor-infiltrating lymphocytes in patients with ovarian or peritoneal carcinoma. (10873077)
2000
42
BRCA1 mutations in Taiwanese with epithelial ovarian carcinoma and sporadic primary serous peritoneal carcinoma. (11059339)
2000
43
Detecting abnormal cells from primary serous peritoneal carcinoma by Pap smear. (10579010)
1999
44
A phase I trial of intravenous melphalan, paclitaxel, and cisplatin plus granulocyte-colony stimulating factor in patients with suboptimal advanced epithelial ovarian carcinoma or peritoneal carcinoma. (10590370)
1999
45
Importance of lymph node metastases in primary peritoneal carcinoma. (9701204)
1998
46
Evidence that a "treatment-free interval of less than 6 months" does not equate with clinically defined platinum resistance in ovarian cancer or primary peritoneal carcinoma. (9692840)
1998
47
Extraovarian primary peritoneal carcinoma. (9644683)
1998
48
Two sequential studies for primary peritoneal carcinoma: induction with weekly cisplatin followed by either cisplatin-doxorubicin-cyclophosphamide or paclitaxel-cisplatin. (9367697)
1997
49
Primary peritoneal carcinoma: a treatable subset of patients with adenocarcinoma of unknown primary. (8602811)
1996
50
Surgically documented responses to paclitaxel and cisplatin in patients with primary peritoneal carcinoma. (8690292)
1996

Variations for Peritoneal Carcinoma

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Expression for genes affiliated with Peritoneal Carcinoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Peritoneal Carcinoma

Search GEO for disease gene expression data for Peritoneal Carcinoma.

Pathways for genes affiliated with Peritoneal Carcinoma

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Sources:
51PathCards, 13EMD Millipore, 56Reactome, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN, 61Thomson Reuters, 5Cell Signaling Technology
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Pathways related to Peritoneal Carcinoma according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3BRCA2, BRCA1
2
Show member pathways
9.3BRCA2, BRCA1
39.3BRCA1, BRCA2
4
Show member pathways
Signaling Pathways in Glioblastoma39
9.3BRCA1, BRCA2
59.3BRCA1, BRCA2
6
Show member pathways
9.3BRCA1, BRCA2
79.3BRCA1, BRCA2
8
Show member pathways
9.3BRCA1, BRCA2
9
Show member pathways
8.8BRCA2, BRCA1, ERCC1
10
Show member pathways
8.8ERCC1, BRCA1, BRCA2
118.8ERCC1, BRCA1, BRCA2
12
Show member pathways
8.8ERCC1, BRCA1, BRCA2

Compounds for genes affiliated with Peritoneal Carcinoma

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Sources:
46Novoseek, 25HMDB, 52PharmGKB, 12DrugBank, 3BitterDB, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Peritoneal Carcinoma according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
18-oxoguanine469.7BRCA2, BRCA1
2daidzein469.7BRCA2, BRCA1
3lycopene46 2510.7BRCA2, BRCA1
4vinorelbine46 52 1211.7BRCA1, ERCC1
5platinum46 5210.7ERCC1, BRCA1
6indole-3-carbinol469.7BRCA2, BRCA1
7chloroquine46 3 52 30 1213.7CXCL10, BRCA1
8methylmethanesulfonate469.7BRCA1, BRCA2
9benzo(a)pyrene469.7ERCC1, BRCA1
10oxaliplatin46 52 1211.7BRCA1, ERCC1
114-hydroxytamoxifen469.7BRCA2, BRCA1
12bleomycin46 1210.7BRCA1, BRCA2
13carboplatin46 52 1211.6ERCC1, BRCA1
14adpribose469.6BRCA2, BRCA1
15hydroxyurea46 52 1211.6BRCA1, BRCA2
16gemcitabine46 52 1211.6ERCC1, BRCA1
17lactacystin469.6ERCC1, BRCA1
18p003469.6BRCA2, BRCA1
19thymidylate469.6ERCC1, BRCA1
20p002469.5BRCA1, BRCA2
21resveratrol46 62 25 1212.5BRCA2, BRCA1
22adriamycin469.5BRCA1, BRCA2
23camptothecin46 62 1211.4BRCA1, BRCA2
24cyclophosphamide46 52 1211.3BRCA1, ERCC1
25glycerol46 25 1211.3ERCC1, BRCA1
26gold469.3CXCL10, BRCA1, BRCA2
27mitomycin c469.3ERCC1, BRCA1, BRCA2
28vincristine46 52 1211.3BRCA2, BRCA1, ERCC1
29docetaxel46 52 62 1212.2BRCA2, BRCA1, ERCC1
30cycloheximide469.2CXCL10, BRCA1, BRCA2
31methotrexate52 46 1211.2ERCC1, BRCA1, BRCA2
32etoposide46 52 62 1212.2ERCC1, BRCA1, BRCA2
33progesterone46 30 62 25 1213.2CXCL10, BRCA1, BRCA2
34paclitaxel46 52 1211.2ERCC1, BRCA1, BRCA2
35cisplatin46 52 62 1212.2ERCC1, BRCA1, BRCA2
36heparan sulfate46 2510.1CXCL10, RET
37folate469.0BRCA1, BRCA2
38adenine46 25 1211.0RET, CXCL10, BRCA1
39paraffin468.9RET, BRCA1, BRCA2
40testosterone46 62 25 1211.9RET, BRCA1, BRCA2
41alanine468.8RET, CXCL10, BRCA1
42thymidine46 259.8BRCA2, BRCA1, CXCL10, ERCC1
43estrogen468.8BRCA2, BRCA1, CXCL10, ERCC1
44atp46 309.6BRCA1, CXCL10, RET
45genistein46 30 62 3 25 1213.5BRCA2, BRCA1, CXCL10, RET
46vegf468.5BRCA1, CXCL10, RET, ERCC1
47retinoic acid46 259.5BRCA2, BRCA1, CXCL10, RET
48tyrosine468.4BRCA1, CXCL10, RET, ERCC1
49oligonucleotide468.4ERCC1, RET, BRCA1, BRCA2
50phosphatidylinositol468.0ERCC1, RET, CXCL10, BRCA1, BRCA2

GO Terms for genes affiliated with Peritoneal Carcinoma

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17Gene Ontology
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Cellular components related to Peritoneal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056548.8ERCC1, BRCA1, BRCA2

Biological processes related to Peritoneal Carcinoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1response to X-rayGO:0101659.6BRCA2, ERCC1
2response to gamma radiationGO:0103329.6BRCA2, CXCL10
3DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.5BRCA1, BRCA2
4regulation of cell proliferationGO:0421279.4CXCL10, BRCA1
5double-strand break repair via homologous recombinationGO:0007249.2BRCA2, BRCA1
6nucleotide-excision repairGO:0062899.1ERCC1, BRCA2
7double-strand break repairGO:0063029.0ERCC1, BRCA1, BRCA2
8DNA repairGO:0062818.9ERCC1, BRCA1, BRCA2
9positive regulation of transcription, DNA-templatedGO:0458938.5RET, BRCA1, BRCA2

Molecular functions related to Peritoneal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1single-stranded DNA bindingGO:0036979.1ERCC1, BRCA2
2protein bindingGO:0055157.5ERCC1, RET, CXCL10, BRCA1, BRCA2

Products for genes affiliated with Peritoneal Carcinoma

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  • Antibodies
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Sources for Peritoneal Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet