MCID: PRT070
MIFTS: 47

Peritoneal Carcinoma malady

Cancer category

Summaries for Peritoneal Carcinoma

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33MalaCards
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MalaCards: Peritoneal Carcinoma, also known as malignant tumor of peritoneum, is related to papillary carcinoma and adenocarcinoma. An important gene associated with Peritoneal Carcinoma is CXCL10 (chemokine (C-X-C motif) ligand 10), and among its related pathways are TGF-Beta Pathway and DNA damage DNA-damage-induced responses. The compounds cycloheximide and adriamycin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lymph node, and related mouse phenotypes are limbs/digits/tail and muscle.

Aliases & Classifications for Peritoneal Carcinoma

Sources:
10DISEASES, 45Novoseek, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

peritoneal carcinoma 10
malignant tumor of peritoneum 61
carcinoma of peritoneum 61
peritoneal cancer 45


Related Diseases for Peritoneal Carcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Peritoneal Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 163)
idRelated DiseaseScoreTop Affiliating Genes
1papillary carcinoma30.2ERBB2, PGR, RET, MUC16, BRCA2
2adenocarcinoma30.2BRCA1, BRCA2, EGFR, MUC16, PGR, CXCL10
3oral cancer29.9EGFR, TP53
4brain cancer29.9EGFR, TP53
5primary peritoneal carcinoma11.0
6ovarian epithelial cancer10.2
7peritoneal serous papillary adenocarcinoma10.1
8tuberculosis10.1
9peritonitis10.0MUC16
10cystadenoma10.0BRCA1
11herpes simplex10.0CXCL10
12pleurisy10.0MUC16
13colon adenocarcinoma10.0CEACAM5
14wilms tumor10.0BRCA2
15leiomyoma10.0PGR
16meningioma10.0PGR
17uterine carcinosarcoma10.0ERBB2
18biliary atresia10.0CXCL10
19arthropathy10.0CXCL10
20dermatomyositis10.0MUC16
21angiomyolipoma10.0PGR
22neurofibromatosis10.0RET
23severe acute respiratory syndrome10.0CXCL10
24breast-ovarian cancer, familial, 210.0BRCA2
25hepatitis10.0CXCL10
26mycosis fungoides10.0CXCL10
27hemangioma10.0RET
28von hippel-lindau disease10.0RET
29parathyroid carcinoma10.0RET
30pulmonary fibrosis10.0IL8
31hyperparathyroidism10.0RET
32papilloma10.0TP53
33connective tissue disease10.0IL10
34osteosarcoma10.0TP53
35toxic shock syndrome10.0IFNG
36ependymoma10.0EGFR
37galactosemia10.0IL10
38alopecia areata10.0IFNG
39rhabdomyosarcoma10.0TP53
40anaplastic large cell lymphoma10.0MUC16
41rhinitis10.0IL8
42skin cancer10.0TP53
43multiple myeloma10.0TP53
44peutz-jeghers syndrome10.0BRCA2
45oral cavity cancer10.0TP53
46struma ovarii10.0MUC16
47neuroblastoma10.0TP53
48malignant mesothelioma10.0MUC16, CEACAM5
49severe combined immunodeficiency10.0IFNG
50meningitis10.0IL8, CXCL10

Graphical network of the top 20 diseases related to Peritoneal Carcinoma:



Diseases related to peritoneal carcinoma

Clinical Features for Peritoneal Carcinoma

Drugs & Therapeutics for Peritoneal Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Peritoneal Carcinoma

Drug clinical trials:

Search ClinicalTrials for Peritoneal Carcinoma

Search NIH Clinical Center for Peritoneal Carcinoma

Search CenterWatch for Peritoneal Carcinoma

Genetic Tests for Peritoneal Carcinoma

Anatomical Context for Peritoneal Carcinoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Peritoneal Carcinoma:

33
Bone marrow, Whole blood, Lymph node, Brain, Small intestine, Colon, Liver, Lung, Pancreas, Breast, Ovary, T cells, B cells, Endothelial, Appendix

Animal Models for Peritoneal Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Peritoneal Carcinoma

Sources:
51PubMed
See all sources

Articles related to Peritoneal Carcinoma:

(show top 50)    (show all 362)
idTitleAuthorsYear
1
A prospective pilot study to assess neo-adjuvant chemotherapy for unresectable peritoneal carcinomatosis from colorectal cancer. (24433532)
2014
2
Association between Rash and a Positive Drug Response Associated with Vinorelbine in a Patient with Primary Peritoneal Carcinoma. (24073344)
2013
3
Treatment and prevention of peritoneal carcinomatosis from gastric cancer by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: overview and rationale. (24183797)
2013
4
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis from small bowel adenocarcinoma. (23711278)
2013
5
First documented case of endometrial carcinoma in a patient treated with tamoxifen for encapsulating peritoneal sclerosis. (23660615)
2013
6
A phase II study of a urokinase-derived peptide (A6) in the treatment of persistent or recurrent epithelial ovarian, fallopian tube, or primary peritoneal carcinoma: a Gynecologic Oncology Group study. (22446624)
2012
7
High-grade primary peritoneal serous papillary carcinoma with a wide differential diagnosis: a diagnostic challenge. (23547430)
2012
8
The cytotoxic effect of TGF-I^1 on mesothelial cells via apoptosis in early peritoneal carcinomatosis. (22447164)
2012
9
Paclitaxel plus Carboplatin Chemotherapy for Primary Peritoneal Carcinoma: A Study of 22 Cases and Comparison with Stage III-IV Ovarian Serous Carcinoma. (22666209)
2012
10
Comparison between peritoneal tuberculosis and primary peritoneal carcinoma: a 16-year, single-center experience. (22964319)
2012
11
Clinical significance of minimal ascites of indeterminate nature in gastric adenocarcinoma without peritoneal carcinomatosis: long-term follow-up study. (21510301)
2011
12
The diagnostic and molecular characteristics of malignant mesothelioma and ovarian/peritoneal serous carcinoma. (21114695)
2011
13
A phase II study of sunitinib in patients with recurrent epithelial ovarian and primary peritoneal carcinoma: an NCIC Clinical Trials Group Study. (20705911)
2011
14
Single nucleotide polypmorphisms in ERCC1 are associated with disease progression, and survival in patients with advanced stage ovarian and primary peritoneal carcinoma; a Gynecologic Oncology Group study. (21496891)
2011
15
p53 signature and serous tubal in-situ carcinoma in cases of primary tubal and peritoneal carcinomas and serous borderline tumors of the ovary. (21804388)
2011
16
Low-grade serous primary peritoneal carcinoma. (21397305)
2011
17
Tertiary syphilis mimicking hepatic metastases of underlying primary peritoneal serous carcinoma. (21161022)
2010
18
Peritoneal tuberculosis: a retrospective review of 20 cases and comparison with primary peritoneal carcinoma. (20973271)
2010
19
Extraovarian peritoneal serous papillary carcinoma: a case report. (21053561)
2010
20
Induction of papillary carcinoma in human ovarian surface epithelial cells using combined genetic elements and peritoneal microenvironment. (20016289)
2010
21
Phase I trial of autologous hematopoietic SCT with escalating doses of topotecan combined with CY and carboplatin in patients with relapsed or persistent ovarian or primary peritoneal carcinoma. (19648970)
2010
22
A contemporary analysis of the ability of preoperative serum CA-125 to predict primary cytoreductive outcome in patients with advanced ovarian, tubal and peritoneal carcinoma. (19100916)
2009
23
Cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis from small bowel adenocarcinoma. (19544356)
2009
24
Rare form of extraovarian peritoneal serous papillary carcinoma with solitary tumor in the abdominal wall: a case report and literature review. (20144179)
2009
25
REG1A expression is a prognostic marker in colorectal cancer and associated with peritoneal carcinomatosis. (18452172)
2008
26
Mucoepidermoid carcinoma of the parotid gland with ovarian and peritoneal metastasis. (18412796)
2008
27
Primary peritoneal serous papillary carcinoma: clinical and laboratory characteristics. (18488238)
2008
28
Paclitaxel, carboplatin and pegylated liposomal doxorubicin in ovarian and peritoneal carcinoma: a phase I study of the Gynecologic Oncology Group. (16959305)
2007
29
A synergistic antitumor effect of interleukin-2 addition with CD80 immunogene therapy for peritoneal metastasis of gastric carcinoma. (17404853)
2007
30
Primary peritoneal carcinoma: a rare neoplasm with pleomorphic trophoblastic morphology. (16907865)
2006
31
Effects of the angiogenesis inhibitor angiostatin on the growth of CC531 colon carcinoma cells in vitro and in a laparoscopic animal model of peritoneal carcinomatosis. (16205930)
2006
32
Sequential prolonged oral topotecan and prolonged oral etoposide as second-line therapy in ovarian or peritoneal carcinoma: a phase I Gynecologic Oncology Group study. (16412499)
2006
33
A phase II trial of weekly paclitaxel and every 3 weeks of carboplatin in potentially platinum-sensitive ovarian and peritoneal carcinoma. (15661211)
2005
34
Peritoneal carcinoma in women with genetic susceptibility: implications for Jewish populations. (15516851)
2004
35
Intraperitoneal chemohyperthermia and attempted cytoreductive surgery in patients with peritoneal carcinomatosis of colorectal origin. (15164446)
2004
36
Phase II study of CT-2103 in patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal carcinoma. (15542803)
2004
37
A phase II study of docetaxel in paclitaxel-resistant ovarian and peritoneal carcinoma: a Gynecologic Oncology Group study. (12586591)
2003
38
Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cell line by overexpression of bikunin. (12569552)
2003
39
Evaluation of monoclonal humanized anti-HER2 antibody, trastuzumab, in patients with recurrent or refractory ovarian or primary peritoneal carcinoma with overexpression of HER2: a phase II trial of the Gynecologic Oncology Group. (12525520)
2003
40
Expression of matrix metalloproteinases-2 and -9 by cells isolated from the peritoneal fluid of women with ovarian carcinoma. (12146034)
2002
41
Lymphatic spread among women with primary peritoneal carcinoma. (12407724)
2002
42
Positive emission tomography for evaluating a complete clinical response in patients with ovarian or peritoneal carcinoma: correlation with second-look laparotomy. (11426956)
2001
43
Ovarian endometriosis and clear cell carcinoma, leiomyomatosis peritonealis disseminata, and endometrial adenocarcinoma: an unusual, pathogenetically related association. (11444203)
2001
44
Adenovirus-mediated transfection of caspase-8 augments anoikis and inhibits peritoneal dissemination of human gastric carcinoma cells. (11585725)
2001
45
Hyperthermic intraoperative intraperitoneal chemotherapy for peritoneal carcinomatosis and sarcomatosis using a cardioplegia heat exchanger and a two-pump system: a case report. (11131220)
2000
46
Primary peritoneal carcinoma: a report of twelve cases and a review of the literature. (11014956)
2000
47
Regulation of transforming growth factor-beta secretion by human peritoneal mesothelial and ovarian carcinoma cells. (10880260)
2000
48
Second-line therapy with paclitaxel and carboplatin for recurrent disease following first-line therapy with paclitaxel and platinum in ovarian or peritoneal carcinoma. (9552057)
1998
49
Intraoperative hyperthermic lavage with cisplatin for peritoneal carcinomatosis and sarcomatosis. (8834572)
1996
50
Non-ovarian peritoneal papillary serous carcinoma with high CA125 levels. (1503511)
1992

Genetic Variations for Peritoneal Carcinoma

Expression for genes affiliated with Peritoneal Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Peritoneal Carcinoma

Search GEO for disease gene expression data for Peritoneal Carcinoma.

Pathways for genes affiliated with Peritoneal Carcinoma

Sources:
52QIAGEN, 12EMD Millipore, 60Tocris Bioscience, 30KEGG, 38NCBI BioSystems Database, 53R&D Systems, 56SinoBiological
See all sources

Pathways related to Peritoneal Carcinoma according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3ERBB2
210.1TP53, BRCA1
3
Hide members
10.1TP53, ERBB2
410.0ERCC1, BRCA2, BRCA1
510.0MIR195, MIR497
69.9TP53, BRCA2, BRCA1
7
DNA damage Role of Brca1 and Brca2 in DNA repair
Hide members
9.9TP53, BRCA2, BRCA1
89.9BRCA1, IFNG, IL8
99.9EGFR, CXCL10, TP53
109.9IL8, IL10, IFNG
119.9TP53, IL8, IFNG
129.8EGFR, ERBB2, TP53
139.8EGFR, ERBB2, TP53
14
Hide members
9.7BRCA1, CXCL10, ERBB2, TP53
15
Hide members
9.7TP53, IL8, BRCA2, BRCA1
169.7BRCA1, BRCA2, EGFR, TP53
17
Hide members
9.7EGFR, CXCL10, ERBB2, TP53
18
Hide members
9.7TP53, ERBB2, EGFR, BRCA2
199.5BRCA1, BRCA2, EGFR, ERBB2, TP53
20
Hide members
9.5IFNG, CXCL10, IL10, IL8, TP53
219.4BRCA1, EGFR, MIR195, ERBB2, TP53
22
Hide members
9.3EGFR, CXCL10, IL10, IL8, ERBB2, TP53
239.2BRCA2, EGFR, RET, IL8, ERBB2, TP53

Compounds for genes affiliated with Peritoneal Carcinoma

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 24HMDB, 2BitterDB
See all sources

Compounds related to Peritoneal Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 123)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.4CXCL10, BRCA1, BRCA2
2adriamycin4510.4PGR, CEACAM5
3dexamethasone45 50 29 1113.3MUC16
4resveratrol45 60 11 2413.3PGR, ERBB2, BRCA2
5tamoxifen45 50 29 1113.2ERBB2, EGFR, PGR
6vinorelbine45 1111.1ERBB2, ERCC1, EGFR, BRCA1
7fluticasone propionate45 50 60 1113.1IL8, IFNG, PGR, CXCL10
8polyinosinic-polycytidylic acid4510.1IL8, IL10, CXCL10, IFNG
9taxane4510.0EGFR, PGR, TP53, ERBB2
10anastrozole45 1111.0PGR, EGFR, ERBB2
11il 104510.0IL8, IL10, CXCL10, IFNG
12tarc4510.0IL8, IL10, CXCL10, IFNG
13ccl345 2911.0IL8, CXCL10, IFNG, IL10
14suberoylanilide hydroxamic acid459.9TP53, EGFR, IFNG, ERBB2
15leucovorin45 50 1111.9CEACAM5, PGR, ERBB2, EGFR
16gold459.9CXCL10, MUC16, BRCA2, CEACAM5
17neopterin459.9IL8, IL10, CXCL10, IFNG
18hydrocortisone45 2 60 1112.9IFNG, ERBB2, CXCL10, IL10, IL8
19capecitabine45 50 1111.9PGR, ERBB2, EGFR
20irinotecan45 50 1111.8CEACAM5, ERBB2, ERCC1, EGFR, TP53
21melphalan45 1110.8ERCC1, TP53, MUC16, IFNG
22methotrexate45 50 1111.8ERCC1, ERBB2, IL10, PGR, BRCA2, BRCA1
23exemestane50 45 60 1112.8PGR, ERBB2, EGFR
24topotecan45 1110.8EGFR, ERBB2, TP53, MUC16, BRCA1
254-hydroxytamoxifen459.8EGFR, PGR, ERBB2, IFNG, BRCA2, BRCA1
26bortezomib45 1110.7TP53, EGFR, BRCA1, ERBB2
27gemcitabine45 50 1111.7IL10, ERBB2, EGFR, BRCA1, ERCC1, TP53
28thymidylate459.7EGFR, BRCA1, IL10, ERCC1, ERBB2, TP53
29adpribose459.7BRCA1, TP53, BRCA2, EGFR
30mitomycin c459.7TP53, BRCA1, BRCA2, IL10, ERCC1, CEACAM5
31oxaliplatin45 50 1111.7BRCA1, CEACAM5, TP53, EGFR, ERBB2, ERCC1
32herbimycin a45 6010.6ERBB2, RET, EGFR, IFNG, IL8
33docetaxel45 50 60 1112.6EGFR, BRCA2, PGR, ERBB2, TP53, BRCA1
34lapatinib45 50 1111.6PGR, EGFR, ERBB2
35cyclophosphamide45 50 1111.5ERCC1, TP53, IL10, ERBB2, PGR, MUC16
36agar459.5CEACAM5, BRCA1, EGFR, RET, PGR, ERBB2
37carboplatin45 50 1111.4ERCC1, IFNG, BRCA1, EGFR, MUC16, ERBB2
38ly294002459.4RET, EGFR, IL10, IL8, ERBB2, TP53
39thymidine45 2410.3IL10, ERCC1, CEACAM5, TP53, CXCL10, IFNG
40paclitaxel45 50 1111.3TP53, ERBB2, PGR, MUC16, EGFR, BRCA2
415fluorouracil459.3CEACAM5, IFNG, EGFR, PGR, BRCA1, ERCC1
42doxorubicin45 50 1111.2EGFR, TP53, MUC16, CEACAM5, PGR, ERCC1
43phosphatidylinositol459.2BRCA2, ERCC1, BRCA1, CEACAM5, EGFR, CXCL10
44testosterone45 60 11 2412.2RET, PGR, MUC16, EGFR, BRCA2, ERBB2
45cisplatin45 50 60 1112.2ERCC1, MUC16, EGFR, ERBB2, TP53, CEACAM5
46genistein45 29 60 2 11 2414.1PGR, CXCL10, RET, IFNG, BRCA2, BRCA1
47retinoic acid45 2410.0TP53, CXCL10, PGR, RET, BRCA2, EGFR
48progesterone45 60 29 11 2413.0MUC16, ERBB2, PGR, TP53, EGFR, BRCA2
49paraffin458.7IL10, CEACAM5, ERBB2, BRCA1, PGR, RET
50vegf458.1EGFR, ERCC1, IL10, CXCL10, PGR, RET

GO Terms for genes affiliated with Peritoneal Carcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Peritoneal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.2IL8, IL10, CXCL10, MUC16, EGFR, IFNG

Biological processes related to Peritoneal Carcinoma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:04534810.2IFNG, IL10
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.2BRCA1, BRCA2, TP53
3response to X-rayGO:01016510.1TP53, ERCC1, BRCA2
4response to gamma radiationGO:01033210.1BRCA2, CXCL10, TP53
5double-strand break repairGO:00630210.0TP53, ERCC1, BRCA2, BRCA1
6nucleotide-excision repairGO:00628910.0BRCA2, ERCC1, TP53
7cellular response to lipopolysaccharideGO:07122210.0IFNG, IL10, IL8
8response to molecule of bacterial originGO:00223710.0IL10, IL8
9UV protectionGO:0096509.9ERCC1, SCARA3
10cell surface receptor signaling pathwayGO:0071669.9ERBB2, CXCL10, EGFR, IFNG
11positive regulation of transcription, DNA-dependentGO:0458939.4TP53, IL10, RET, BRCA2, BRCA1
12signal transductionGO:0071658.9ERBB2, IL8, CXCL10, PGR, RET, EGFR

Molecular functions related to Peritoneal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:00500610.1ERBB2, EGFR
2transmembrane receptor protein tyrosine kinase activityGO:0047149.8ERBB2, RET, EGFR
3receptor signaling protein tyrosine kinase activityGO:0047169.8ERBB2, EGFR
4protein tyrosine kinase activityGO:0047139.7ERBB2, RET, EGFR
5enzyme bindingGO:0198999.6BRCA1, EGFR, PGR, TP53

Products for genes affiliated with Peritoneal Carcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Peritoneal Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet