MCID: PRT036
MIFTS: 71

Peritonitis malady

Rare diseases, Gastrointestinal diseases categories

Summaries for Peritonitis

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9Disease Ontology, 44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A gastrointestinal system infectious disease that involves inflammation of the peritoneum resulting from perforation of the gastrointestinal tract, which produces immediate chemical inflammation followed shortly by infection from intestinal organisms. peritonitis can also result from appendicitis, diverticulitis, strangulating intestinal obstruction, pancreatitis, pelvic inflammatory disease, mesenteric ischemia, intraperitoneal blood, barium, or peritoneo-systemic shunts, drains, and dialysis catheters in the peritoneal cavity. the symptoms include abdominal pain and tenderness, fever, fluid in the abdomen, nausea, vomiting and low urine output.

MalaCards: Peritonitis, also known as sclerosing mesenteritis, is related to tuberculosis and liver cirrhosis. An important gene associated with Peritonitis is ADA (adenosine deaminase), and among its related pathways are A-beta Uptake and Degradation and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The drugs albumin human, usp and albumin,egg and the compounds hypoxanthine and vitamin b12 have been mentioned in the context of this disorder. Affiliated tissues include liver, endothelial and colon, and related mouse phenotypes are tumorigenesis and normal.

NIH Rare Diseases:44 Sclerosing mesenteritis is oneĀ of many terms used to describe a spectrum of chronic inflammatory diseases affecting the small bowel mesentery, the membrane that anchors the small intestine to the back of the abdominal wall. Ā the cause of this condition is unknown. the most common symptom is abdominal pain or a palpable abdominal mass.click here to view an illustration of the small intestine. last updated: 7/11/2011

Wikipedia:66 Peritonitis is an inflammation of the peritoneum, the thin tissue that lines the inner wall of the... more...

Aliases & Classifications for Peritonitis

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 50Orphanet, 63UMLS, 28ICD9CM, 59SNOMED-CT, 60SNOMED-CT via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

50
sclerosing mesenteritis:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

peritonitis 9 11 46 63
sclerosing mesenteritis 9 44 50
retractile mesenteritis 9 44 63
mesenteric panniculitis 44 50 63
acute generalized peritonitis 9 63
primary bacterial peritonitis 9 63
liposclerotic mesenteritis 44 50
mesenteric lipogranuloma 44 50
peritoneal retractile mesenteritis 44
idiopathic sclerosing mesenteritis 44
spontaneous bacterial peritonitis 9
isolated mesenteric lipodystrophy 50
mesenteric lipodystrophy 44
mesenteric fibromatosis 44
lipomatous mesenteritis 50
fibromatosis, abdominal 63


External Ids:

Disease Ontology9 DOID:8283
ICD9CM28 567.89, 567.8
SNOMED-CT via Orphanet60 86422009
ICD1026 K65, K65.9

Related Diseases for Peritonitis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Peritonitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 671)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis30.9CTSG, TBP, ALB, ADA
2liver cirrhosis30.6LBP, SERPINB2, ALB, CD14
3hypertension30.4ALB, CCL2
4atherosclerosis30.2SERPINB2, CMA1, MMP8, CCL2, ALB, CD14
5pneumonia30.2CTSG, CCL2, MMP8, LBP
6sepsis30.2CTSG, CD14, TBP, ALB, CCL2, SERPINB2
7pericardial effusion30.1ADA
8sarcoidosis30.1CD14, CCL2, ADA
9systemic lupus erythematosus30.1FCGR3B, FCGR1A, ADA, CCL2, TBP, CTSG
10glomerulonephritis30.1CTSG, ALB, CCL2
11meningitis30.1ALB, ADA, LBP
12primary hyperoxaluria30.1CTSG, CD14, ALB, CCL2
13chronic kidney failure30.0LBP, ADA, ALB, CD14
14hyperhomocysteinemia30.0CCL2, ALB
15septic shock29.9LBP, FCGR1A, CD14
16pulmonary tuberculosis29.9ADA, CD14
17abdominal aortic aneurysm29.9CCL2, MMP8
18nephritis29.9ALB, CCL2, FCGR3B
19arthritis29.8LBP, FCGR3B, FCGR1A, MMP8, CCL2, ALB
20inflammatory bowel disease29.8FCGR1A, CCL2, CD14, CTSG
21pleural tuberculosis29.7CCL2, ADA
22membranous glomerulonephritis29.7CCL2, ALB
23uveitis29.7CD14, CCL2
24lupus nephritis29.7CTSG, ALB, CCL2
25ulcerative colitis29.6CTSG, ALB
26adult respiratory distress syndrome29.6LBP, CD14
27alcoholic hepatitis29.6ALB, CCL2, LBP
28bacterial meningitis29.6ADA, MMP8, LBP
29cystic fibrosis29.6CTSG, ALB, LBP
30vasculitis29.5CTSG, CD14, ALB, CCL2, FCGR3B
31rheumatoid arthritis29.5LBP, FCGR3B, FCGR1A, SERPINB2, MMP8, ADA
32leukemia29.5FCGR3B, SERPINB2, ADA, CD14, CTSG
33burkitt's lymphoma29.5FCGR3B, FCGR1A, SERPINB2, ADA, ALB, CD14
34breast cancer29.5FCGR1A, SERPINB2, MMP8, ADA, ALB, CD14
35tuberculous peritonitis11.0
36peritoneal mesothelioma10.9
37endometriosis10.9
38malignant peritoneal mesothelioma10.9
39peritoneal carcinoma10.8
40primary peritoneal carcinoma10.8
41ovarian cancer10.6
42endotheliitis10.6
43adenocarcinoma10.6
44lipodystrophy10.5
45intestinal perforation10.5
46pancreatitis10.5
47pseudomyxoma peritonei10.5
48benign multicystic peritoneal mesothelioma10.5
49hepatitis10.5
50leiomyomatosis10.5

Graphical network of the top 20 diseases related to Peritonitis:



Diseases related to peritonitis

Symptoms for Peritonitis

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Drugs & Therapeutics for Peritonitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Peritonitis

Drug clinical trials:

Search ClinicalTrials for Peritonitis

Search NIH Clinical Center for Peritonitis

Search CenterWatch for Peritonitis

Inferred drug relations via UMLS63/NDF-RT42:

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Genetic Tests for Peritonitis

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Anatomical Context for Peritonitis

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34MalaCards
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MalaCards organs/tissues related to Peritonitis:

34
Liver, Endothelial, Colon, Monocytes, Small intestine, Kidney, Bone, T cells, Ovary, Testes, Lung, Lymph node, Heart, Brain, Pancreas, Skin, Breast, Smooth muscle, Spleen, Bone marrow, B cells, Appendix, Adipocyte, Spinal cord, Pineal, Eye, Whole blood, Prostate, Testis, Thyroid, Nk cells, B lymphoblasts, Myeloid, Uterus

Animal Models for Peritonitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Peritonitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8CTSG, ALB, CCL2, MMP8
2MP:00028738.3FCGR1A, ADA, CCL2, ALB, CTSG
3MP:00053708.3LBP, ADA, CCL2, ALB, CTSG
4MP:00107687.7SERPINB2, ADA, CCL2, ALB, TBP, CD14
5MP:00053767.5LBP, SERPINB2, ADA, CCL2, ALB, TBP
6MP:00053976.9LBP, FCGR1A, SERPINB2, CMA1, ADA, CCL2
7MP:00053876.4CTSG, LBP, FCGR1A, SERPINB2, CMA1, MMP8

Publications for Peritonitis

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Sources:
53PubMed
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Articles related to Peritonitis:

(show top 50)    (show all 4026)
idTitleAuthorsYear
1
Sepsis is associated with altered cerebral microcirculation and tissue hypoxia in experimental peritonitis*. (24196192)
2014
2
Predictive factors that influence the survival rates in liver cirrhosis patients with spontaneous bacterial peritonitis. (23837137)
2013
3
Acute chylous peritonitis: Report of a case. (23500748)
2013
4
Zinc transporter 5 and zinc transporter 7 induced by high glucose protects peritoneal mesothelial cells from undergoing apoptosis. (23275032)
2013
5
Effect of chloroquine on feline infectious peritonitis virus infection in vitro and in vivo. (23648708)
2013
6
Spontaneous bacterial peritonitis in Dakar, Senegal: study of 55 patients with cirrhosis. (24317300)
2013
7
PD-L1 on tumor cells is induced in ascites and promotes peritoneal dissemination of ovarian cancer through CTL dysfunction. (23340297)
2013
8
Gangrenous appendicitis presenting as acute abdominal pain in a patient on automated peritoneal dialysis: a case report. (22989294)
2012
9
A case of cell-free and concentrated ascites reinfusion therapy effective for refractory ascites in spontaneous bacterial peritonitis in a renal transplant patient. (23289021)
2012
10
Peritonitis caused by Haemophilus parainfluenzae, Leifsonia aquatica, and Gordonia spp. in a patient undergoing continuous ambulatory peritoneal dialysis. (23268614)
2012
11
Recurrent acute pancreatitis in a patient on peritoneal dialysis using 7.5% icodextrin. (22991018)
2012
12
Giant and multiple jejunal diverticula presenting as peritonitis a significant challenging disorder. (23049633)
2012
13
Patients with peritoneal mesothelioma lack epidermal growth factor receptor tyrosine kinase mutations that would make them sensitive to tyrosine kinase inhibitors. (22426987)
2012
14
Spontaneous bacterial peritonitis: a rare mimic of acute appendicitis. (22510192)
2012
15
Multidrug resistance gene (MDR-1) and risk of brain metastasis in epithelial ovarian, fallopian tube, and peritoneal cancer. (20921883)
2011
16
The influence of risk factors in remodelling carotid arteries in patients undergoing peritoneal dialysis. (20433437)
2010
17
Peroxisome-proliferator activator receptor-gamma activation decreases attachment of endometrial cells to peritoneal mesothelial cells in an in vitro model of the early endometriotic lesion. (19643817)
2009
18
Disseminated cryptococcosis with meningitis, peritonitis, and cryptococcemia in a HIV-negative patient with cirrhosis: a case report. (19946481)
2009
19
Vascular cell adhesion molecule-1 is a regulator of ovarian cancer peritoneal metastasis. (19208843)
2009
20
Combination chemotherapy with cisplatin and gemcitabine in malignant peritoneal mesothelioma. (19593622)
2009
21
Lipid disorders, statins and the peritoneal membrane. (19494612)
2009
22
The TIMP-1 gene transferred through adenovirus mediation shows a suppressive effect on peritoneal metastases from gastric cancer. (17380436)
2007
23
Paclitaxel, carboplatin and pegylated liposomal doxorubicin in ovarian and peritoneal carcinoma: a phase I study of the Gynecologic Oncology Group. (16959305)
2007
24
Education and imaging. Gastrointestinal: malignant peritoneal mesothelioma. (16911701)
2006
25
Immunohistochemical analysis of peritoneal mesothelioma and primary and secondary serous carcinoma of the peritoneum: antibodies to estrogen and progesterone receptors are useful. (16482993)
2006
26
Effects of human peritoneal mesothelial cells on angiogenesis factor expression and secretion of ovarian carcinoma cells]. (17366783)
2006
27
Peritoneal tuberculosis mimicking advanced ovarian cancer: a retrospective review of 22 cases. (16740297)
2006
28
Mixed cryoglobulinemia with renal failure, cutaneous vasculitis and peritonitis due to Brucella melitensis. (15951018)
2005
29
Inhibitory effect of Buthus martensi Karsch extracts on interleukin-1beta-induced expression of nitric oxide (NO) synthase and production of NO in human chondrocytes and LPS-induced NO and prostaglandin E2 production in mouse peritoneal macrophages. (15963682)
2005
30
Observations on salpingitis, peritonitis and salpingoperitonitis in a layer breeder flock. (16272543)
2005
31
Primary peritoneal malignant mixed mA1llerian tumor associated with colonic adenocarcinoma. (16285567)
2005
32
Peritoneal fluid concentrations of interleukin-17 correlate with the severity of endometriosis and infertility of this disorder. (16045534)
2005
33
Treatment of terminal peritoneal carcinomatosis by a transducible p53-activating peptide. (14966535)
2004
34
Gemcitabine and cisplatin chemotherapy is an active combination in the treatment of platinum-resistant ovarian and peritoneal carcinoma. (15292718)
2004
35
Increased pregnancy-associated plasma protein-A (PAPP-A) concentrations in peritoneal fluid of women with endometriosis. (12765344)
2003
36
Aberrant T cell activation and heightened apoptotic turnover in end-stage renal failure patients: a comparative evaluation between non-dialysis, haemodialysis, and peritoneal dialysis. (12914790)
2003
37
Peritoneal carcinoma in a male patient. (12759547)
2003
38
Effects of pentoxifylline on peritoneal fibroblasts and silica-induced peritoneal fibrosis. (12938822)
2003
39
Positive emission tomography for evaluating a complete clinical response in patients with ovarian or peritoneal carcinoma: correlation with second-look laparotomy. (11426956)
2001
40
Rapid quantitative detection of carcinoembryonic antigen-expressing free tumor cells in the peritoneal cavity of gastric-cancer patients with real-time RT-PCR on the lightcycler. (11008202)
2000
41
Therapy of acute variceal hemorrhage and spontaneous bacterial peritonitis in liver cirrhosis]. (9789469)
1998
42
Effects of bio-normalizer (a food supplementation) on free radical production by human blood neutrophils, erythrocytes, and rat peritoneal macrophages. (8748224)
1995
43
Regulation of equine fibrinolysis in blood and peritoneal fluid based on a study of colic cases and induced endotoxaemia. (7889922)
1994
44
Fibrinolytic activity of ascites caused by alcoholic cirrhosis and peritoneal malignancy. (8174965)
1993
45
Release of tumor necrosis factor alpha by human peritoneal macrophages in response to toxic shock syndrome toxin-1. (2067760)
1991
46
Studies of peritoneal macrophage function in murine systemic lupus erythematosus. 2. Nature of elevated resident peritoneal cells in NZB and (NZB x NZW)F1 mice. (3861745)
1985
47
Peritonitis in a patient with hepatorenal syndrome. (6731713)
1984
48
Tuberculous peritonitis. (515768)
1979
49
Gonococcal vulvovaginitis and possible peritonitis in prepubertal girls. (4996392)
1971
50
Tuberculous peritonitis treated with streptomycin. (14779387)
1950

Variations for Peritonitis

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Expression for genes affiliated with Peritonitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Peritonitis

Search GEO for disease gene expression data for Peritonitis.

Pathways for genes affiliated with Peritonitis

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Sources:
51PathCards, 55R&D Systems, 52PharmGKB, 31KEGG, 39NCBI BioSystems Database, 61Thomson Reuters, 56Reactome, 13EMD Millipore, 54QIAGEN
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Pathways related to Peritonitis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CCL2, CD14
2
Show member pathways
9.6CTSG, CMA1
3
Show member pathways
9.3CD14, LBP
49.3FCGR3B, FCGR1A, CD14
59.1CTSG, ALB, MMP8
6
Show member pathways
9.1CTSG, MMP8, CMA1
7
Show member pathways
9.1CMA1, MMP8, CTSG
89.0CTSG, CD14, SERPINB2
9
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.0CD14, CCL2, LBP
10
Show member pathways
8.8TBP, MMP8, FCGR1A, FCGR3B
11
Show member pathways
8.8CTSG, TBP, FCGR1A, FCGR3B
128.5CD14, FCGR1A, FCGR3B, LBP

Compounds for genes affiliated with Peritonitis

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Sources:
46Novoseek, 25HMDB, 12DrugBank, 52PharmGKB, 30IUPHAR, 62Tocris Bioscience, 3BitterDB
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Compounds related to Peritonitis according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1hypoxanthine46 25 1211.9CD14, TBP, ADA
2vitamin b12469.9ADA, ALB, CCL2
3zidovudine46 52 1211.8ALB, ADA, CCL2
4monophosphoryl lipid a469.6CD14, LBP
5tositumomab52 1210.6FCGR1A, FCGR3B
6tetracycline46 1210.5ALB, MMP8, CCL2
7nitroblue tetrazolium469.5SERPINB2, CD14, FCGR1A
8vitamin d469.5CCL2, ALB, TBP, CD14
9sodium dodecylsulfate469.4CCL2, ALB, TBP, CTSG
10polysulfone469.4CD14, ALB, LBP
11prednisolone46 30 1211.4CD14, ALB, FCGR1A, FCGR3B
12scca1469.4CMA1, CTSG, SERPINB2
13polymyxin b469.3CD14, CCL2, LBP
14lipoteichoic acid469.3LBP, CD14, CCL2
15xanthine46 2510.3CD14, CTSG, ADA, MMP8
16leukotriene b446 62 2511.2CCL2, FCGR3B, CTSG
17glutamine469.2TBP, CD14, CCL2, FCGR1A, ADA
18peptidoglycan46 3010.1LBP, CD14, CTSG
19homocysteine46 2510.1LBP, CD14, ALB, CCL2
20lactate468.9CD14, ADA, ALB, CTSG, MMP8
21genistein46 30 62 3 25 1213.9FCGR3B, FCGR1A, MMP8, CCL2
22polyacrylamide468.8CTSG, CD14, LBP, TBP
23histamine46 30 2510.8CMA1, CCL2, CD14, ADA, ALB, CTSG
24cyclosporin a46 30 6210.7ADA, CD14, SERPINB2, MMP8
25paraffin468.7CTSG, SERPINB2, CMA1, CD14, CCL2
26vegf468.7SERPINB2, ADA, MMP8, CD14, CCL2
27pge2468.6FCGR1A, SERPINB2, MMP8, CCL2, CD14
28fmlp468.6CD14, FCGR3B, CCL2, CTSG, ADA, FCGR1A
29arachidonic acid46 30 25 1211.6CTSG, ALB, FCGR1A, LBP
30actinomycin d468.5SERPINB2, CCL2, LBP, FCGR1A
31polysaccharide468.4LBP, FCGR3B, CTSG, CD14, CCL2
32creatinine468.3LBP, CTSG, CD14, ALB, CCL2, ADA
33aspartate468.3LBP, ALB, CD14, ADA, CTSG, CCL2
34cholesterol46 30 25 1211.3CD14, CCL2, CMA1, FCGR1A, LBP, ALB
35cysteine468.3CD14, TBP, CTSG, ALB, MMP8, CMA1
36endotoxin468.3SERPINB2, LBP, CD14, CCL2, CTSG
37retinoic acid46 259.3MMP8, TBP, CD14, CTSG, SERPINB2, ADA
38hydrogen46 259.2SERPINB2, CTSG, MMP8, TBP
39h2o2468.1FCGR1A, CTSG, MMP8, FCGR3B, SERPINB2, ADA
40oxygen46 259.0MMP8, LBP, TBP, FCGR1A, CCL2
41heparin46 30 25 1211.0CTSG, CMA1, SERPINB2, ALB, CD14, LBP
42nitric oxide46 25 129.9SERPINB2, CCL2, CTSG, MMP8, LBP
43alanine467.9ADA, LBP, TBP, ALB, MMP8, CTSG
44cycloheximide467.8CD14, CTSG, SERPINB2, CCL2, FCGR1A, LBP
45dexamethasone46 52 30 1210.8CCL2, TBP, CD14, ADA, SERPINB2, FCGR1A
46fibrinogen467.1MMP8, SERPINB2, CCL2, ALB, CTSG, LBP
47calcium46 52 25 1210.0FCGR1A, SERPINB2, FCGR3B, CCL2, ALB, CD14
48superoxide46 257.9MMP8, FCGR1A, CD14, SERPINB2, CTSG, LBP
49lipid466.6CD14, ALB, CCL2, MMP8, FCGR3B, LBP
50serine466.2CTSG, FCGR3B, SERPINB2, MMP8, LBP, CMA1

GO Terms for genes affiliated with Peritonitis

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17Gene Ontology
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Cellular components related to Peritonitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099868.5CTSG, CD14, ADA, LBP
2extracellular spaceGO:0056156.5LBP, SERPINB2, MMP8, ADA, CCL2, ALB
3extracellular regionGO:0055766.1CTSG, LBP, FCGR3B, SERPINB2, CMA1, MMP8

Biological processes related to Peritonitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1angiotensin maturationGO:0020039.8CTSG, CMA1
2response to heatGO:0094089.7CCL2, CD14
3cellular response to lipoteichoic acidGO:0712239.6CD14, LBP
4lipopolysaccharide-mediated signaling pathwayGO:0316639.4CCL2, LBP
5positive regulation of tumor necrosis factor productionGO:0327609.3CD14, LBP
6negative regulation of growth of symbiont in hostGO:0441309.3CTSG, LBP
7extracellular matrix disassemblyGO:0226179.3CMA1, MMP8, CTSG
8cellular response to lipopolysaccharideGO:0712229.2CD14, CCL2, LBP
9proteolysisGO:0065089.2CMA1, MMP8, CTSG
10immune responseGO:0069559.1CTSG, FCGR1A, FCGR3B
11extracellular matrix organizationGO:0301988.8CTSG, MMP8, CMA1

Molecular functions related to Peritonitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:0198649.5FCGR1A, FCGR3B
2lipoteichoic acid bindingGO:0708919.3CD14, LBP
3serine-type endopeptidase activityGO:0042529.1CTSG, MMP8, CMA1
4lipopolysaccharide bindingGO:0015309.0CD14, LBP

Products for genes affiliated with Peritonitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Peritonitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet