MCID: PRT036
MIFTS: 72

Peritonitis malady

Rare diseases, Gastrointestinal diseases categories
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Summaries for Peritonitis

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Disease Ontology:8 A gastrointestinal system infectious disease that involves inflammation of the peritoneum resulting from perforation of the gastrointestinal tract, which produces immediate chemical inflammation followed shortly by infection from intestinal organisms. peritonitis can also result from appendicitis, diverticulitis, strangulating intestinal obstruction, pancreatitis, pelvic inflammatory disease, mesenteric ischemia, intraperitoneal blood, barium, or peritoneo-systemic shunts, drains, and dialysis catheters in the peritoneal cavity. the symptoms include abdominal pain and tenderness, fever, fluid in the abdomen, nausea, vomiting and low urine output.

MalaCards based summary: Peritonitis, also known as liposclerotic mesenteritis, is related to tuberculosis and hypertension. An important gene associated with Peritonitis is ADA (adenosine deaminase), and among its related pathways are A-beta Uptake and Degradation and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The drugs albumin human, usp and albumin,egg and the compounds hypoxanthine and vitamin b12 have been mentioned in the context of this disorder. Affiliated tissues include liver, endothelial and colon, and related mouse phenotypes are tumorigenesis and normal.

NIH Rare Diseases:42 Sclerosing mesenteritis is one of many terms used to describe a spectrum of chronic inflammatory diseases affecting the small bowel mesentery, the membrane that anchors the small intestine to the back of the abdominal wall.  the cause of this condition is unknown. the most common symptom is abdominal pain or a palpable abdominal mass.click here to view an illustration of the small intestine. last updated: 7/11/2011

Wikipedia:65 Peritonitis is defined as inflammation of the peritoneum, the thin tissue that lines the inner wall of... more...

Aliases & Classifications for Peritonitis

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Peritonitis, Aliases & Descriptions:

Name: Peritonitis 8 10 44 62
Liposclerotic Mesenteritis 42 48 62
Sclerosing Mesenteritis 8 42 48
Retractile Mesenteritis 8 42 62
Mesenteric Panniculitis 42 48 62
Peritoneal Retractile Mesenteritis 42 62
Spontaneous Bacterial Peritonitis 8 62
Primary Bacterial Peritonitis 8 62
 
Acute Generalized Peritonitis 8 62
Mesenteric Lipogranuloma 42 48
Mesenteric Lipodystrophy 42 62
Idiopathic Sclerosing Mesenteritis 42
Isolated Mesenteric Lipodystrophy 48
Lipomatous Mesenteritis 48
Mesenteric Fibromatosis 42
Fibromatosis, Abdominal 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

48
liposclerotic mesenteritis:
Inheritance: Sporadic; Age of onset: Adulthood


External Ids:

Disease Ontology8 DOID:8283
ICD9CM27 567.89, 567.8
ICD1025 K65, K65.9

Related Diseases for Peritonitis

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Diseases related to Peritonitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 695)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis31.1CTSG, ALB, TBP, ADA
2hypertension30.9ALB, CCL2
3pericardial effusion30.7ADA
4sarcoidosis30.4CD14, ADA, CCL2
5liver cirrhosis30.3ALB, SERPINB2, LBP, CD14
6pulmonary tuberculosis30.3ADA, CD14
7glomerulonephritis30.3ALB, CCL2, CTSG
8hyperhomocysteinemia30.2CCL2, ALB
9pleural tuberculosis30.2CCL2, ADA
10abdominal aortic aneurysm30.2MMP8, CCL2
11meningitis30.2ADA, ALB, LBP
12membranous glomerulonephritis30.1CCL2, ALB
13nephritis30.1CCL2, FCGR3B, ALB
14primary hyperoxaluria30.1CCL2, ALB, CD14, CTSG
15septic shock30.0FCGR1A, LBP, CD14
16chronic kidney failure30.0ADA, LBP, CD14, ALB
17uveitis29.9CD14, CCL2
18lupus nephritis29.9CTSG, ALB, CCL2
19pneumonia29.9MMP8, CTSG, LBP, CCL2
20inflammatory bowel disease29.8CTSG, CCL2, CD14, FCGR1A
21ulcerative colitis29.8ALB, CTSG
22atherosclerosis29.8CD14, CMA1, ALB, CCL2, SERPINB2, MMP8
23systemic lupus erythematosus29.8FCGR3B, CTSG, CCL2, ADA, FCGR1A, TBP
24adult respiratory distress syndrome29.8LBP, CD14
25alcoholic hepatitis29.7LBP, CCL2, ALB
26bacterial meningitis29.6MMP8, LBP, ADA
27cystic fibrosis29.4CTSG, LBP, ALB
28vasculitis29.4FCGR3B, CCL2, ALB, CTSG, CD14
29leukemia29.2FCGR3B, SERPINB2, ADA, CD14, CTSG
30burkitt's lymphoma29.1ADA, FCGR3B, CD14, ALB, SERPINB2, FCGR1A
31arthritis29.0FCGR3B, FCGR1A, LBP, CCL2, CTSG, ALB
32breast cancer29.0MMP8, FCGR1A, SERPINB2, ALB, CD14, ADA
33sepsis28.9ALB, CD14, CTSG, CCL2, SERPINB2, FCGR1A
34rheumatoid arthritis28.3FCGR3B, LBP, FCGR1A, ADA, SERPINB2, CTSG
35tuberculous peritonitis11.0
36peritoneal mesothelioma11.0
37endometriosis10.9
38malignant peritoneal mesothelioma10.9
39peritoneal carcinoma10.8
40gastric cancer10.8
41primary peritoneal carcinoma10.8
42ovarian cancer10.7
43endotheliitis10.6
44adenocarcinoma10.6
45intestinal perforation10.5
46lipodystrophy10.5
47benign multicystic peritoneal mesothelioma10.5
48leiomyomatosis10.5
49pancreatitis10.5
50pseudomyxoma peritonei10.5

Graphical network of the top 20 diseases related to Peritonitis:



Diseases related to peritonitis

Symptoms for Peritonitis

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Drugs & Therapeutics for Peritonitis

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Drug clinical trials:

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Search NIH Clinical Center for Peritonitis

Inferred drug relations via UMLS62/NDF-RT40:

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Genetic Tests for Peritonitis

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Anatomical Context for Peritonitis

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MalaCards organs/tissues related to Peritonitis:

32
Liver, Endothelial, Colon, Monocytes, Small intestine, Kidney, Neutrophil, Appendix, T cells, Bone, Ovary, Testes, Lung, Lymph node, Heart, Brain, Pancreas, Skin, Breast, Bone marrow, Spleen, Smooth muscle, B cells, Spinal cord, Adipocyte, Uterus, Pineal, Eye, Whole blood, Thyroid, Prostate, Testis, Myeloid, Nk cells, B lymphoblasts

Animal Models for Peritonitis or affiliated genes

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MGI Mouse Phenotypes related to Peritonitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8CTSG, ALB, CCL2, MMP8
2MP:00028738.3FCGR1A, ADA, CCL2, ALB, CTSG
3MP:00053708.3LBP, ADA, CCL2, ALB, CTSG
4MP:00107687.7SERPINB2, ADA, CCL2, ALB, TBP, CD14
5MP:00053767.5LBP, SERPINB2, ADA, CCL2, ALB, TBP
6MP:00053976.9LBP, FCGR1A, SERPINB2, CMA1, ADA, CCL2
7MP:00053876.4CTSG, LBP, FCGR1A, SERPINB2, CMA1, MMP8

Publications for Peritonitis

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Articles related to Peritonitis:

(show top 50)    (show all 4171)
idTitleAuthorsYear
1
Sepsis is associated with altered cerebral microcirculation and tissue hypoxia in experimental peritonitis*. (24196192)
2014
2
Effect of Initial Empiric Antibiotic Therapy Combined with Control of the Infection Focus on the Prognosis of Patients with Secondary Peritonitis. (25397738)
2014
3
Predictive factors that influence the survival rates in liver cirrhosis patients with spontaneous bacterial peritonitis. (23837137)
2013
4
Acute chylous peritonitis: Report of a case. (23500748)
2013
5
Zinc transporter 5 and zinc transporter 7 induced by high glucose protects peritoneal mesothelial cells from undergoing apoptosis. (23275032)
2013
6
Effect of chloroquine on feline infectious peritonitis virus infection in vitro and in vivo. (23648708)
2013
7
Spontaneous bacterial peritonitis in Dakar, Senegal: study of 55 patients with cirrhosis. (24317300)
2013
8
PD-L1 on tumor cells is induced in ascites and promotes peritoneal dissemination of ovarian cancer through CTL dysfunction. (23340297)
2013
9
Gangrenous appendicitis presenting as acute abdominal pain in a patient on automated peritoneal dialysis: a case report. (22989294)
2012
10
A case of cell-free and concentrated ascites reinfusion therapy effective for refractory ascites in spontaneous bacterial peritonitis in a renal transplant patient. (23289021)
2012
11
Peritonitis caused by Haemophilus parainfluenzae, Leifsonia aquatica, and Gordonia spp. in a patient undergoing continuous ambulatory peritoneal dialysis. (23268614)
2012
12
Recurrent acute pancreatitis in a patient on peritoneal dialysis using 7.5% icodextrin. (22991018)
2012
13
Giant and multiple jejunal diverticula presenting as peritonitis a significant challenging disorder. (23049633)
2012
14
Patients with peritoneal mesothelioma lack epidermal growth factor receptor tyrosine kinase mutations that would make them sensitive to tyrosine kinase inhibitors. (22426987)
2012
15
Spontaneous bacterial peritonitis: a rare mimic of acute appendicitis. (22510192)
2012
16
Multidrug resistance gene (MDR-1) and risk of brain metastasis in epithelial ovarian, fallopian tube, and peritoneal cancer. (20921883)
2011
17
The influence of risk factors in remodelling carotid arteries in patients undergoing peritoneal dialysis. (20433437)
2010
18
Peroxisome-proliferator activator receptor-gamma activation decreases attachment of endometrial cells to peritoneal mesothelial cells in an in vitro model of the early endometriotic lesion. (19643817)
2009
19
Disseminated cryptococcosis with meningitis, peritonitis, and cryptococcemia in a HIV-negative patient with cirrhosis: a case report. (19946481)
2009
20
Vascular cell adhesion molecule-1 is a regulator of ovarian cancer peritoneal metastasis. (19208843)
2009
21
Combination chemotherapy with cisplatin and gemcitabine in malignant peritoneal mesothelioma. (19593622)
2009
22
Lipid disorders, statins and the peritoneal membrane. (19494612)
2009
23
The TIMP-1 gene transferred through adenovirus mediation shows a suppressive effect on peritoneal metastases from gastric cancer. (17380436)
2007
24
Paclitaxel, carboplatin and pegylated liposomal doxorubicin in ovarian and peritoneal carcinoma: a phase I study of the Gynecologic Oncology Group. (16959305)
2007
25
Education and imaging. Gastrointestinal: malignant peritoneal mesothelioma. (16911701)
2006
26
Immunohistochemical analysis of peritoneal mesothelioma and primary and secondary serous carcinoma of the peritoneum: antibodies to estrogen and progesterone receptors are useful. (16482993)
2006
27
Effects of human peritoneal mesothelial cells on angiogenesis factor expression and secretion of ovarian carcinoma cells]. (17366783)
2006
28
Peritoneal tuberculosis mimicking advanced ovarian cancer: a retrospective review of 22 cases. (16740297)
2006
29
Mixed cryoglobulinemia with renal failure, cutaneous vasculitis and peritonitis due to Brucella melitensis. (15951018)
2005
30
Inhibitory effect of Buthus martensi Karsch extracts on interleukin-1beta-induced expression of nitric oxide (NO) synthase and production of NO in human chondrocytes and LPS-induced NO and prostaglandin E2 production in mouse peritoneal macrophages. (15963682)
2005
31
Observations on salpingitis, peritonitis and salpingoperitonitis in a layer breeder flock. (16272543)
2005
32
Primary peritoneal malignant mixed mA1llerian tumor associated with colonic adenocarcinoma. (16285567)
2005
33
Peritoneal fluid concentrations of interleukin-17 correlate with the severity of endometriosis and infertility of this disorder. (16045534)
2005
34
Treatment of terminal peritoneal carcinomatosis by a transducible p53-activating peptide. (14966535)
2004
35
Gemcitabine and cisplatin chemotherapy is an active combination in the treatment of platinum-resistant ovarian and peritoneal carcinoma. (15292718)
2004
36
Increased pregnancy-associated plasma protein-A (PAPP-A) concentrations in peritoneal fluid of women with endometriosis. (12765344)
2003
37
Aberrant T cell activation and heightened apoptotic turnover in end-stage renal failure patients: a comparative evaluation between non-dialysis, haemodialysis, and peritoneal dialysis. (12914790)
2003
38
Peritoneal carcinoma in a male patient. (12759547)
2003
39
Effects of pentoxifylline on peritoneal fibroblasts and silica-induced peritoneal fibrosis. (12938822)
2003
40
Positive emission tomography for evaluating a complete clinical response in patients with ovarian or peritoneal carcinoma: correlation with second-look laparotomy. (11426956)
2001
41
Rapid quantitative detection of carcinoembryonic antigen-expressing free tumor cells in the peritoneal cavity of gastric-cancer patients with real-time RT-PCR on the lightcycler. (11008202)
2000
42
Therapy of acute variceal hemorrhage and spontaneous bacterial peritonitis in liver cirrhosis]. (9789469)
1998
43
Effects of bio-normalizer (a food supplementation) on free radical production by human blood neutrophils, erythrocytes, and rat peritoneal macrophages. (8748224)
1995
44
Regulation of equine fibrinolysis in blood and peritoneal fluid based on a study of colic cases and induced endotoxaemia. (7889922)
1994
45
Fibrinolytic activity of ascites caused by alcoholic cirrhosis and peritoneal malignancy. (8174965)
1993
46
Release of tumor necrosis factor alpha by human peritoneal macrophages in response to toxic shock syndrome toxin-1. (2067760)
1991
47
Studies of peritoneal macrophage function in murine systemic lupus erythematosus. 2. Nature of elevated resident peritoneal cells in NZB and (NZB x NZW)F1 mice. (3861745)
1985
48
Tuberculous peritonitis. (515768)
1979
49
Gonococcal vulvovaginitis and possible peritonitis in prepubertal girls. (4996392)
1971
50
Tuberculous peritonitis treated with streptomycin. (14779387)
1950

Variations for Peritonitis

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Expression for genes affiliated with Peritonitis

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Expression patterns in normal tissues for genes affiliated with Peritonitis

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Pathways for genes affiliated with Peritonitis

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Pathways related to Peritonitis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CCL2, CD14
2
Show member pathways
9.6CTSG, CMA1
3
Show member pathways
9.3CD14, LBP
49.3FCGR3B, FCGR1A, CD14
59.1CTSG, ALB, MMP8
6
Show member pathways
9.1CTSG, MMP8, CMA1
7
Show member pathways
9.1CMA1, MMP8, CTSG
89.0CTSG, CD14, SERPINB2
9
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.0CD14, CCL2, LBP
10
Show member pathways
8.8TBP, MMP8, FCGR1A, FCGR3B
11
Show member pathways
8.8CTSG, TBP, FCGR1A, FCGR3B
128.5CD14, FCGR1A, FCGR3B, LBP

Compounds for genes affiliated with Peritonitis

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Compounds related to Peritonitis according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1hypoxanthine44 24 1111.9CD14, TBP, ADA
2vitamin b12449.9ALB, CCL2, ADA
3zidovudine44 50 1111.8ALB, CCL2, ADA
4monophosphoryl lipid a449.6CD14, LBP
5tositumomab50 1110.6FCGR1A, FCGR3B
6tetracycline44 1110.5ALB, CCL2, MMP8
7nitroblue tetrazolium449.5CD14, SERPINB2, FCGR1A
8vitamin d449.5CCL2, ALB, TBP, CD14
9sodium dodecylsulfate449.4CTSG, TBP, ALB, CCL2
10polysulfone449.4CD14, ALB, LBP
11prednisolone44 28 1111.4CD14, ALB, FCGR1A, FCGR3B
12scca1449.4CTSG, CMA1, SERPINB2
13polymyxin b449.3CD14, CCL2, LBP
14lipoteichoic acid449.3CD14, CCL2, LBP
15xanthine44 2410.3MMP8, ADA, CD14, CTSG
16leukotriene b444 61 2411.2FCGR3B, CCL2, CTSG
17glutamine449.2FCGR1A, ADA, CCL2, TBP, CD14
18peptidoglycan44 2810.1LBP, CD14, CTSG
19homocysteine44 2410.1LBP, CCL2, ALB, CD14
20lactate448.9MMP8, ADA, ALB, CD14, CTSG
21genistein44 28 61 2 24 1113.9FCGR3B, FCGR1A, MMP8, CCL2
22polyacrylamide448.8LBP, TBP, CD14, CTSG
23histamine44 28 2410.8CMA1, ADA, CCL2, ALB, CD14, CTSG
24cyclosporin a44 28 6110.7CD14, ADA, MMP8, SERPINB2
25paraffin448.7SERPINB2, CMA1, CCL2, CD14, CTSG
26vegf448.7CD14, CCL2, ADA, MMP8, SERPINB2
27pge2448.6FCGR1A, SERPINB2, MMP8, CCL2, CD14
28fmlp448.6FCGR3B, FCGR1A, ADA, CCL2, CD14, CTSG
29arachidonic acid44 28 24 1111.6CTSG, ALB, FCGR1A, LBP
30actinomycin d448.5LBP, FCGR1A, SERPINB2, CCL2
31polysaccharide448.4LBP, FCGR3B, CCL2, CD14, CTSG
32creatinine448.3LBP, ADA, CCL2, ALB, CD14, CTSG
33aspartate448.3LBP, ADA, CCL2, ALB, CD14, CTSG
34cholesterol44 28 24 1111.3LBP, FCGR1A, CMA1, CCL2, ALB, CD14
35cysteine448.3CMA1, MMP8, ADA, ALB, TBP, CD14
36endotoxin448.3LBP, SERPINB2, CCL2, CD14, CTSG
37retinoic acid44 249.3SERPINB2, MMP8, ADA, TBP, CD14, CTSG
38hydrogen44 249.2CTSG, TBP, MMP8, SERPINB2
39h2o2448.1FCGR3B, FCGR1A, SERPINB2, MMP8, ADA, CTSG
40oxygen44 249.0LBP, FCGR1A, MMP8, CCL2, TBP
41heparin44 28 24 1111.0LBP, SERPINB2, CMA1, ALB, CD14, CTSG
42nitric oxide44 24 119.9LBP, SERPINB2, MMP8, CCL2, CTSG
43alanine447.9LBP, MMP8, ADA, ALB, TBP, CD14
44cycloheximide447.8LBP, FCGR1A, SERPINB2, CCL2, CD14, CTSG
45dexamethasone44 50 28 1110.8LBP, FCGR1A, SERPINB2, ADA, CCL2, TBP
46fibrinogen447.1CTSG, LBP, FCGR1A, SERPINB2, MMP8, CCL2
47calcium44 50 24 1110.0FCGR3B, FCGR1A, SERPINB2, CMA1, MMP8, CCL2
48superoxide44 247.9LBP, FCGR3B, FCGR1A, SERPINB2, MMP8, CCL2
49lipid446.6LBP, FCGR3B, FCGR1A, SERPINB2, MMP8, CCL2
50serine446.2LBP, FCGR3B, FCGR1A, SERPINB2, CMA1, MMP8

GO Terms for genes affiliated with Peritonitis

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Cellular components related to Peritonitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099868.5CTSG, CD14, ADA, LBP
2extracellular spaceGO:0056156.5LBP, SERPINB2, MMP8, ADA, CCL2, ALB
3extracellular regionGO:0055766.1CTSG, LBP, FCGR3B, SERPINB2, CMA1, MMP8

Biological processes related to Peritonitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1angiotensin maturationGO:0020039.8CTSG, CMA1
2response to heatGO:0094089.7CCL2, CD14
3cellular response to lipoteichoic acidGO:0712239.6CD14, LBP
4lipopolysaccharide-mediated signaling pathwayGO:0316639.4CCL2, LBP
5positive regulation of tumor necrosis factor productionGO:0327609.3CD14, LBP
6negative regulation of growth of symbiont in hostGO:0441309.3CTSG, LBP
7extracellular matrix disassemblyGO:0226179.3CMA1, MMP8, CTSG
8cellular response to lipopolysaccharideGO:0712229.2CD14, CCL2, LBP
9proteolysisGO:0065089.2CMA1, MMP8, CTSG
10immune responseGO:0069559.1CTSG, FCGR1A, FCGR3B
11extracellular matrix organizationGO:0301988.8CTSG, MMP8, CMA1

Molecular functions related to Peritonitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:0198649.5FCGR1A, FCGR3B
2lipoteichoic acid bindingGO:0708919.3CD14, LBP
3serine-type endopeptidase activityGO:0042529.1CTSG, MMP8, CMA1
4lipopolysaccharide bindingGO:0015309.0CD14, LBP

Products for genes affiliated with Peritonitis

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Sources for Peritonitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet