MCID: PRT036
MIFTS: 61

Peritonitis malady

Rare diseases, Gastrointestinal diseases categories

Aliases & Classifications for Peritonitis

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Peritonitis, Aliases & Descriptions:

Name: Peritonitis 9 11 43 60
Sclerosing Mesenteritis 9 41 47
Retractile Mesenteritis 9 41 60
Mesenteric Panniculitis 41 47 60
Peritoneal Retractile Mesenteritis 41 60
Isolated Mesenteric Lipodystrophy 41 47
Acute Generalized Peritonitis 9 60
Primary Bacterial Peritonitis 9 60
 
Liposclerotic Mesenteritis 41 47
Mesenteric Lipogranuloma 41 47
Lipomatous Mesenteritis 41 47
Idiopathic Sclerosing Mesenteritis 41
Spontaneous Bacterial Peritonitis 9
Mesenteric Lipodystrophy 41
Mesenteric Fibromatosis 41
Fibromatosis, Abdominal 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

47
sclerosing mesenteritis:
Inheritance: Not applicable; Age of onset: Adult


External Ids:

Disease Ontology9 DOID:8283
ICD9CM27 567.8, 567.89
Orphanet47 238593
ICD1025 K65, K65.9

Summaries for Peritonitis

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Disease Ontology:9 A gastrointestinal system disease that involves inflammation of the peritoneum resulting from perforation of the gastrointestinal tract, which produces immediate chemical inflammation followed shortly by infection from intestinal organisms. peritonitis can also result from appendicitis, diverticulitis, strangulating intestinal obstruction, pancreatitis, pelvic inflammatory disease, mesenteric ischemia, intraperitoneal blood, barium, or peritoneo-systemic shunts, drains, and dialysis catheters in the peritoneal cavity. the symptoms include abdominal pain and tenderness, fever, fluid in the abdomen, nausea, vomiting and low urine output.

MalaCards based summary: Peritonitis, also known as sclerosing mesenteritis, is related to tuberculosis and pericardial effusion. An important gene associated with Peritonitis is ADA (adenosine deaminase), and among its related pathways are A-beta Uptake and Degradation and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The drugs albumin human, usp and albumin,human inj and the compounds hypoxanthine and vitamin b12 have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and endothelial, and related mouse phenotypes are tumorigenesis and normal.

NIH Rare Diseases:41 Sclerosing mesenteritis is one of many terms used to describe a spectrum of chronic inflammatory diseases affecting the small bowel mesentery, the membrane that anchors the small intestine to the back of the abdominal wall.  the cause of this condition is unknown. the most common symptom is abdominal pain or a palpable abdominal mass.click here to view an illustration of the small intestine. last updated: 7/11/2011

Wikipedia:63 Peritonitis is an inflammation of the peritoneum, the thin tissue that lines the inner wall of the... more...

Related Diseases for Peritonitis

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Diseases related to Peritonitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 662)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis31.1CTSG, ALB, TBP, ADA
2pericardial effusion30.7ADA
3liver cirrhosis30.3ALB, SERPINB2, LBP, CD14
4pulmonary tuberculosis30.3ADA, CD14
5glomerulonephritis30.3ALB, CCL2, CTSG
6hyperhomocysteinemia30.2CCL2, ALB
7pleural tuberculosis30.2CCL2, ADA
8abdominal aortic aneurysm30.2MMP8, CCL2
9meningitis30.2ADA, ALB, LBP
10nephritis30.1CCL2, FCGR3B, ALB
11dermatitis30.1CD14, CMA1
12primary hyperoxaluria30.1CCL2, ALB, CD14, CTSG
13chronic kidney failure30.0ADA, LBP, CD14, ALB
14uveitis29.9CD14, CCL2
15lupus nephritis29.9CTSG, ALB, CCL2
16pneumonia29.8MMP8, CTSG, LBP, CCL2
17inflammatory bowel disease29.8CTSG, CCL2, CD14, FCGR1A
18ulcerative colitis29.8ALB, CTSG
19atherosclerosis29.8CD14, CMA1, ALB, CCL2, SERPINB2, MMP8
20systemic lupus erythematosus29.8FCGR3B, CTSG, CCL2, ADA, FCGR1A, TBP
21alcoholic hepatitis29.7LBP, CCL2, ALB
22hiv-129.7ADA, FCGR3B, FCGR1A, CD14
23bacterial meningitis29.6MMP8, LBP, ADA
24cystic fibrosis29.4CTSG, LBP, ALB
25leukemia29.1FCGR3B, SERPINB2, ADA, CD14, CTSG
26arthritis29.0FCGR3B, FCGR1A, LBP, CCL2, CTSG, ALB
27breast cancer29.0MMP8, FCGR1A, SERPINB2, ALB, CD14, ADA
28rheumatoid arthritis28.3FCGR3B, LBP, FCGR1A, ADA, SERPINB2, CTSG
29tuberculous peritonitis11.0
30mesothelioma11.0
31peritoneal mesothelioma11.0
32endometriosis10.9
33malignant peritoneal mesothelioma10.9
34peritoneal carcinoma10.8
35primary peritoneal carcinoma10.8
36adenocarcinoma10.6
37endotheliitis10.6
38intestinal perforation10.6
39pancreatitis10.5
40benign multicystic peritoneal mesothelioma10.5
41lipodystrophy10.5
42leiomyomatosis10.5
43hepatitis10.5
44pseudomyxoma peritonei10.5
45mycobacterium fortuitum10.5
46cholangitis10.5ALB
47end stage renal failure10.5
48appendicitis10.5
49salpingitis10.4
50sarcomatosis10.4

Graphical network of the top 20 diseases related to Peritonitis:



Diseases related to peritonitis

Symptoms for Peritonitis

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Drugs & Therapeutics for Peritonitis

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Drug clinical trials:

Search ClinicalTrials for Peritonitis

Search NIH Clinical Center for Peritonitis

Inferred drug relations via UMLS60/NDF-RT39:

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Genetic Tests for Peritonitis

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Anatomical Context for Peritonitis

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MalaCards organs/tissues related to Peritonitis:

31
Liver, Colon, Endothelial, Kidney, Monocytes, Small intestine, Neutrophil, Appendix, T cells, Bone, Testes, Ovary, Lung, Lymph node, Heart, Brain, Pancreas, Skin, Breast, Bone marrow, Spleen, Smooth muscle, B cells, Adipocyte, Uterus, Pineal, Whole blood, Spinal cord, Thyroid, Prostate, Testis, Myeloid, Eye, Nk cells, B lymphoblasts

Animal Models for Peritonitis or affiliated genes

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MGI Mouse Phenotypes related to Peritonitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8CTSG, ALB, CCL2, MMP8
2MP:00028738.3FCGR1A, ADA, CCL2, ALB, CTSG
3MP:00053708.3LBP, ADA, CCL2, ALB, CTSG
4MP:00107687.7SERPINB2, ADA, CCL2, ALB, TBP, CD14
5MP:00053767.5LBP, SERPINB2, ADA, CCL2, ALB, TBP
6MP:00053976.9LBP, FCGR1A, SERPINB2, CMA1, ADA, CCL2
7MP:00053876.4CTSG, LBP, FCGR1A, SERPINB2, CMA1, MMP8

Publications for Peritonitis

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Articles related to Peritonitis:

(show top 50)    (show all 4223)
idTitleAuthorsYear
1
Sepsis is associated with altered cerebral microcirculation and tissue hypoxia in experimental peritonitis*. (24196192)
2014
2
Effect of Initial Empiric Antibiotic Therapy Combined with Control of the Infection Focus on the Prognosis of Patients with Secondary Peritonitis. (25397738)
2014
3
Predictive factors that influence the survival rates in liver cirrhosis patients with spontaneous bacterial peritonitis. (23837137)
2013
4
Acute chylous peritonitis: Report of a case. (23500748)
2013
5
Zinc transporter 5 and zinc transporter 7 induced by high glucose protects peritoneal mesothelial cells from undergoing apoptosis. (23275032)
2013
6
Effect of chloroquine on feline infectious peritonitis virus infection in vitro and in vivo. (23648708)
2013
7
Spontaneous bacterial peritonitis in Dakar, Senegal: study of 55 patients with cirrhosis. (24317300)
2013
8
PD-L1 on tumor cells is induced in ascites and promotes peritoneal dissemination of ovarian cancer through CTL dysfunction. (23340297)
2013
9
Gangrenous appendicitis presenting as acute abdominal pain in a patient on automated peritoneal dialysis: a case report. (22989294)
2012
10
A case of cell-free and concentrated ascites reinfusion therapy effective for refractory ascites in spontaneous bacterial peritonitis in a renal transplant patient. (23289021)
2012
11
Peritonitis caused by Haemophilus parainfluenzae, Leifsonia aquatica, and Gordonia spp. in a patient undergoing continuous ambulatory peritoneal dialysis. (23268614)
2012
12
Recurrent acute pancreatitis in a patient on peritoneal dialysis using 7.5% icodextrin. (22991018)
2012
13
Giant and multiple jejunal diverticula presenting as peritonitis a significant challenging disorder. (23049633)
2012
14
Patients with peritoneal mesothelioma lack epidermal growth factor receptor tyrosine kinase mutations that would make them sensitive to tyrosine kinase inhibitors. (22426987)
2012
15
Spontaneous bacterial peritonitis: a rare mimic of acute appendicitis. (22510192)
2012
16
Multidrug resistance gene (MDR-1) and risk of brain metastasis in epithelial ovarian, fallopian tube, and peritoneal cancer. (20921883)
2011
17
The influence of risk factors in remodelling carotid arteries in patients undergoing peritoneal dialysis. (20433437)
2010
18
Peroxisome-proliferator activator receptor-gamma activation decreases attachment of endometrial cells to peritoneal mesothelial cells in an in vitro model of the early endometriotic lesion. (19643817)
2009
19
Disseminated cryptococcosis with meningitis, peritonitis, and cryptococcemia in a HIV-negative patient with cirrhosis: a case report. (19946481)
2009
20
Vascular cell adhesion molecule-1 is a regulator of ovarian cancer peritoneal metastasis. (19208843)
2009
21
Combination chemotherapy with cisplatin and gemcitabine in malignant peritoneal mesothelioma. (19593622)
2009
22
Lipid disorders, statins and the peritoneal membrane. (19494612)
2009
23
The TIMP-1 gene transferred through adenovirus mediation shows a suppressive effect on peritoneal metastases from gastric cancer. (17380436)
2007
24
Paclitaxel, carboplatin and pegylated liposomal doxorubicin in ovarian and peritoneal carcinoma: a phase I study of the Gynecologic Oncology Group. (16959305)
2007
25
The effect of pH-neutral peritoneal dialysis fluids on adipokine secretion from cultured adipocytes. (17132702)
2007
26
Education and imaging. Gastrointestinal: malignant peritoneal mesothelioma. (16911701)
2006
27
Immunohistochemical analysis of peritoneal mesothelioma and primary and secondary serous carcinoma of the peritoneum: antibodies to estrogen and progesterone receptors are useful. (16482993)
2006
28
Effects of human peritoneal mesothelial cells on angiogenesis factor expression and secretion of ovarian carcinoma cells]. (17366783)
2006
29
Peritoneal tuberculosis mimicking advanced ovarian cancer: a retrospective review of 22 cases. (16740297)
2006
30
Inhibitory effect of Buthus martensi Karsch extracts on interleukin-1beta-induced expression of nitric oxide (NO) synthase and production of NO in human chondrocytes and LPS-induced NO and prostaglandin E2 production in mouse peritoneal macrophages. (15963682)
2005
31
Observations on salpingitis, peritonitis and salpingoperitonitis in a layer breeder flock. (16272543)
2005
32
Primary peritoneal malignant mixed mA1llerian tumor associated with colonic adenocarcinoma. (16285567)
2005
33
Peritoneal fluid concentrations of interleukin-17 correlate with the severity of endometriosis and infertility of this disorder. (16045534)
2005
34
Treatment of terminal peritoneal carcinomatosis by a transducible p53-activating peptide. (14966535)
2004
35
Gemcitabine and cisplatin chemotherapy is an active combination in the treatment of platinum-resistant ovarian and peritoneal carcinoma. (15292718)
2004
36
Increased pregnancy-associated plasma protein-A (PAPP-A) concentrations in peritoneal fluid of women with endometriosis. (12765344)
2003
37
Peritoneal carcinoma in a male patient. (12759547)
2003
38
Effects of pentoxifylline on peritoneal fibroblasts and silica-induced peritoneal fibrosis. (12938822)
2003
39
Positive emission tomography for evaluating a complete clinical response in patients with ovarian or peritoneal carcinoma: correlation with second-look laparotomy. (11426956)
2001
40
Rapid quantitative detection of carcinoembryonic antigen-expressing free tumor cells in the peritoneal cavity of gastric-cancer patients with real-time RT-PCR on the lightcycler. (11008202)
2000
41
Therapy of acute variceal hemorrhage and spontaneous bacterial peritonitis in liver cirrhosis]. (9789469)
1998
42
Effects of bio-normalizer (a food supplementation) on free radical production by human blood neutrophils, erythrocytes, and rat peritoneal macrophages. (8748224)
1995
43
Regulation of equine fibrinolysis in blood and peritoneal fluid based on a study of colic cases and induced endotoxaemia. (7889922)
1994
44
Fibrinolytic activity of ascites caused by alcoholic cirrhosis and peritoneal malignancy. (8174965)
1993
45
Release of tumor necrosis factor alpha by human peritoneal macrophages in response to toxic shock syndrome toxin-1. (2067760)
1991
46
Studies of peritoneal macrophage function in murine systemic lupus erythematosus. 2. Nature of elevated resident peritoneal cells in NZB and (NZB x NZW)F1 mice. (3861745)
1985
47
Peritonitis in a patient with hepatorenal syndrome. (6731713)
1984
48
Tuberculous peritonitis. (515768)
1979
49
Gonococcal vulvovaginitis and possible peritonitis in prepubertal girls. (4996392)
1971
50
Tuberculous peritonitis treated with streptomycin. (14779387)
1950

Variations for Peritonitis

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Expression for genes affiliated with Peritonitis

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Search GEO for disease gene expression data for Peritonitis.

Pathways for genes affiliated with Peritonitis

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Pathways related to Peritonitis according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CCL2, CD14
2
Show member pathways
9.6CTSG, CMA1
3
Show member pathways
9.3CD14, LBP
49.3FCGR3B, FCGR1A, CD14
5
Show member pathways
9.1CTSG, MMP8, CMA1
6
Show member pathways
9.1CMA1, MMP8, CTSG
79.0CTSG, CD14, SERPINB2
8
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.0CD14, CCL2, LBP
9
Show member pathways
8.8TBP, MMP8, FCGR1A, FCGR3B
10
Show member pathways
8.8CTSG, TBP, FCGR1A, FCGR3B
118.5CD14, FCGR1A, FCGR3B, LBP

Compounds for genes affiliated with Peritonitis

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Compounds related to Peritonitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1hypoxanthine43 24 1211.9CD14, TBP, ADA
2vitamin b12439.9ADA, ALB, CCL2
3zidovudine43 49 1211.8ALB, ADA, CCL2
4monophosphoryl lipid a439.6CD14, LBP
5tositumomab49 1210.6FCGR1A, FCGR3B
6tetracycline43 1210.5ALB, MMP8, CCL2
7nitroblue tetrazolium439.5SERPINB2, CD14, FCGR1A
8vitamin d439.5CCL2, ALB, TBP, CD14
9sodium dodecylsulfate439.4CCL2, ALB, TBP, CTSG
10polysulfone439.4CD14, ALB, LBP
11prednisolone43 28 1211.4CD14, ALB, FCGR1A, FCGR3B
12scca1439.4CMA1, CTSG, SERPINB2
13polymyxin b439.3CD14, CCL2, LBP
14lipoteichoic acid439.3LBP, CD14, CCL2
15xanthine43 2410.3CD14, CTSG, ADA, MMP8
16leukotriene b443 59 2411.2CCL2, FCGR3B, CTSG
17glutamine439.2TBP, CD14, CCL2, FCGR1A, ADA
18peptidoglycan43 2810.1LBP, CD14, CTSG
19homocysteine43 2410.1LBP, CD14, ALB, CCL2
20lactate438.9CD14, ADA, ALB, CTSG, MMP8
21genistein43 28 59 2 24 1213.9FCGR3B, FCGR1A, MMP8, CCL2
22polyacrylamide438.8CTSG, CD14, LBP, TBP
23histamine43 28 2410.8CMA1, CCL2, CD14, ADA, ALB, CTSG
24cyclosporin a43 28 5910.7ADA, CD14, SERPINB2, MMP8
25paraffin438.7CTSG, SERPINB2, CMA1, CD14, CCL2
26vegf438.7SERPINB2, ADA, MMP8, CD14, CCL2
27pge2438.6FCGR1A, SERPINB2, MMP8, CCL2, CD14
28fmlp438.6CD14, FCGR3B, CCL2, CTSG, ADA, FCGR1A
29arachidonic acid43 28 24 1211.6CTSG, ALB, FCGR1A, LBP
30actinomycin d438.5SERPINB2, CCL2, LBP, FCGR1A
31polysaccharide438.4LBP, FCGR3B, CTSG, CD14, CCL2
32creatinine438.3LBP, CTSG, CD14, ALB, CCL2, ADA
33aspartate438.3LBP, ALB, CD14, ADA, CTSG, CCL2
34cholesterol43 28 24 1211.3CD14, CCL2, CMA1, FCGR1A, LBP, ALB
35cysteine438.3CD14, TBP, CTSG, ALB, MMP8, CMA1
36endotoxin438.3SERPINB2, LBP, CD14, CCL2, CTSG
37retinoic acid43 249.3MMP8, TBP, CD14, CTSG, SERPINB2, ADA
38hydrogen43 249.2SERPINB2, CTSG, MMP8, TBP
39h2o2438.1FCGR1A, CTSG, MMP8, FCGR3B, SERPINB2, ADA
40oxygen43 249.0MMP8, LBP, TBP, FCGR1A, CCL2
41heparin43 28 24 1211.0CTSG, CMA1, SERPINB2, ALB, CD14, LBP
42nitric oxide43 24 129.9SERPINB2, CCL2, CTSG, MMP8, LBP
43alanine437.9ADA, LBP, TBP, ALB, MMP8, CTSG
44cycloheximide437.8CD14, CTSG, SERPINB2, CCL2, FCGR1A, LBP
45dexamethasone43 49 28 1210.8CCL2, TBP, CD14, ADA, SERPINB2, FCGR1A
46fibrinogen437.1MMP8, SERPINB2, CCL2, ALB, CTSG, LBP
47calcium43 49 24 1210.0FCGR1A, SERPINB2, FCGR3B, CCL2, ALB, CD14
48superoxide43 247.9MMP8, FCGR1A, CD14, SERPINB2, CTSG, LBP
49lipid436.6CD14, ALB, CCL2, MMP8, FCGR3B, LBP
50serine436.2CTSG, FCGR3B, SERPINB2, MMP8, LBP, CMA1

GO Terms for genes affiliated with Peritonitis

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Cellular components related to Peritonitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099868.5CTSG, CD14, ADA, LBP
2extracellular spaceGO:00056156.5LBP, SERPINB2, MMP8, ADA, CCL2, ALB
3extracellular regionGO:00055766.1CTSG, LBP, FCGR3B, SERPINB2, CMA1, MMP8

Biological processes related to Peritonitis according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1angiotensin maturationGO:00020039.8CTSG, CMA1
2response to heatGO:00094089.7CCL2, CD14
3cellular response to lipoteichoic acidGO:00712239.6CD14, LBP
4lipopolysaccharide-mediated signaling pathwayGO:00316639.4CCL2, LBP
5positive regulation of tumor necrosis factor productionGO:00327609.3CD14, LBP
6negative regulation of growth of symbiont in hostGO:00441309.3CTSG, LBP
7extracellular matrix disassemblyGO:00226179.3CMA1, MMP8, CTSG
8cellular response to lipopolysaccharideGO:00712229.2CD14, CCL2, LBP
9proteolysisGO:00065089.2CMA1, MMP8, CTSG
10immune responseGO:00069559.1CTSG, FCGR1A, FCGR3B
11extracellular matrix organizationGO:00301988.8CTSG, MMP8, CMA1

Molecular functions related to Peritonitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:00198649.5FCGR1A, FCGR3B
2lipoteichoic acid bindingGO:00708919.3CD14, LBP
3serine-type endopeptidase activityGO:00042529.1CTSG, MMP8, CMA1
4lipopolysaccharide bindingGO:00015309.0CD14, LBP

Products for genes affiliated with Peritonitis

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Sources for Peritonitis

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3CDC
13ExPASy
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25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
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39NDF-RT
42NINDS
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46OMIM via Orphanet
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51QIAGEN
56SNOMED-CT via Orphanet
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61UMLS via Orphanet