MCID: PRT036
MIFTS: 61

Peritonitis malady

Rare diseases, Gastrointestinal diseases categories

Aliases & Classifications for Peritonitis

About this section

Aliases & Descriptions for Peritonitis:

Name: Peritonitis 8 10 44 61
Sclerosing Mesenteritis 8 42 48
Retractile Mesenteritis 8 42 61
Mesenteric Panniculitis 42 48 61
Peritoneal Retractile Mesenteritis 42 61
Isolated Mesenteric Lipodystrophy 42 48
Acute Generalized Peritonitis 8 61
Primary Bacterial Peritonitis 8 61
 
Liposclerotic Mesenteritis 42 48
Mesenteric Lipogranuloma 42 48
Lipomatous Mesenteritis 42 48
Idiopathic Sclerosing Mesenteritis 42
Spontaneous Bacterial Peritonitis 8
Mesenteric Lipodystrophy 42
Mesenteric Fibromatosis 42
Fibromatosis, Abdominal 61


Classifications:



Characteristics (Orphanet epidemiological data):

48
sclerosing mesenteritis:
Inheritance: Not applicable; Age of onset: Adult


External Ids:

Disease Ontology8 DOID:8283
ICD9CM27 567.8, 567.89
Orphanet48 238593
ICD1025 K65, K65.9

Summaries for Peritonitis

About this section
Disease Ontology:8 A gastrointestinal system disease that involves inflammation of the peritoneum resulting from perforation of the gastrointestinal tract, which produces immediate chemical inflammation followed shortly by infection from intestinal organisms. peritonitis can also result from appendicitis, diverticulitis, strangulating intestinal obstruction, pancreatitis, pelvic inflammatory disease, mesenteric ischemia, intraperitoneal blood, barium, or peritoneo-systemic shunts, drains, and dialysis catheters in the peritoneal cavity. the symptoms include abdominal pain and tenderness, fever, fluid in the abdomen, nausea, vomiting and low urine output.

MalaCards based summary: Peritonitis, also known as sclerosing mesenteritis, is related to tuberculosis and pericardial effusion. An important gene associated with Peritonitis is ADA (adenosine deaminase), and among its related pathways are A-beta Uptake and Degradation and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The drugs albumin human, usp and albumin,human inj and the compounds hypoxanthine and vitamin b12 have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and endothelial, and related mouse phenotypes are tumorigenesis and normal.

NIH Rare Diseases:42 Sclerosing mesenteritis is one of many terms used to describe a spectrum of chronic inflammatory diseases affecting the small bowel mesentery, the membrane that anchors the small intestine to the back of the abdominal wall.  the cause of this condition is unknown. the most common symptom is abdominal pain or a palpable abdominal mass.click here to view an illustration of the small intestine. last updated: 7/11/2011

Wikipedia:64 Peritonitis is an inflammation of the peritoneum, the thin tissue that lines the inner wall of the... more...

Related Diseases for Peritonitis

About this section

Diseases related to Peritonitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 662)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis31.1CTSG, ALB, TBP, ADA
2pericardial effusion30.7ADA
3liver cirrhosis30.3ALB, SERPINB2, LBP, CD14
4pulmonary tuberculosis30.3ADA, CD14
5glomerulonephritis30.3ALB, CCL2, CTSG
6hyperhomocysteinemia30.2CCL2, ALB
7pleural tuberculosis30.2CCL2, ADA
8abdominal aortic aneurysm30.2MMP8, CCL2
9meningitis30.2ADA, ALB, LBP
10nephritis30.1CCL2, FCGR3B, ALB
11dermatitis30.1CD14, CMA1
12primary hyperoxaluria30.1CCL2, ALB, CD14, CTSG
13chronic kidney failure30.0ADA, LBP, CD14, ALB
14uveitis29.9CD14, CCL2
15lupus nephritis29.9CTSG, ALB, CCL2
16pneumonia29.8MMP8, CTSG, LBP, CCL2
17inflammatory bowel disease29.8CTSG, CCL2, CD14, FCGR1A
18ulcerative colitis29.8ALB, CTSG
19atherosclerosis29.8CD14, CMA1, ALB, CCL2, SERPINB2, MMP8
20systemic lupus erythematosus29.8FCGR3B, CTSG, CCL2, ADA, FCGR1A, TBP
21alcoholic hepatitis29.7LBP, CCL2, ALB
22hiv-129.7ADA, FCGR3B, FCGR1A, CD14
23bacterial meningitis29.6MMP8, LBP, ADA
24cystic fibrosis29.4CTSG, LBP, ALB
25leukemia29.1FCGR3B, SERPINB2, ADA, CD14, CTSG
26arthritis29.0FCGR3B, FCGR1A, LBP, CCL2, CTSG, ALB
27breast cancer29.0MMP8, FCGR1A, SERPINB2, ALB, CD14, ADA
28rheumatoid arthritis28.3FCGR3B, LBP, FCGR1A, ADA, SERPINB2, CTSG
29tuberculous peritonitis11.0
30mesothelioma11.0
31peritoneal mesothelioma11.0
32endometriosis10.9
33malignant peritoneal mesothelioma10.9
34peritoneal carcinoma10.8
35primary peritoneal carcinoma10.8
36adenocarcinoma10.6
37endotheliitis10.6
38intestinal perforation10.6
39pancreatitis10.5
40benign multicystic peritoneal mesothelioma10.5
41lipodystrophy10.5
42leiomyomatosis10.5
43hepatitis10.5
44pseudomyxoma peritonei10.5
45mycobacterium fortuitum10.5
46cholangitis10.5ALB
47end stage renal failure10.5
48appendicitis10.5
49salpingitis10.4
50sarcomatosis10.4

Graphical network of the top 20 diseases related to Peritonitis:



Diseases related to peritonitis

Symptoms for Peritonitis

About this section

Drugs & Therapeutics for Peritonitis

About this section

Drug clinical trials:

Search ClinicalTrials for Peritonitis

Search NIH Clinical Center for Peritonitis

Inferred drug relations via UMLS61/NDF-RT40:

Show with subtypes

Genetic Tests for Peritonitis

About this section

Anatomical Context for Peritonitis

About this section

MalaCards organs/tissues related to Peritonitis:

31
Liver, Colon, Endothelial, Kidney, Monocytes, Small intestine, Neutrophil, Appendix, T cells, Bone, Testes, Ovary, Lung, Lymph node, Heart, Brain, Pancreas, Skin, Breast, Bone marrow, Spleen, Smooth muscle, B cells, Adipocyte, Uterus, Pineal, Whole blood, Spinal cord, Thyroid, Prostate, Testis, Myeloid, Eye, Nk cells, B lymphoblasts

Animal Models for Peritonitis or affiliated genes

About this section

MGI Mouse Phenotypes related to Peritonitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8CTSG, ALB, CCL2, MMP8
2MP:00028738.3FCGR1A, ADA, CCL2, ALB, CTSG
3MP:00053708.3LBP, ADA, CCL2, ALB, CTSG
4MP:00107687.7SERPINB2, ADA, CCL2, ALB, TBP, CD14
5MP:00053767.5LBP, SERPINB2, ADA, CCL2, ALB, TBP
6MP:00053976.9LBP, FCGR1A, SERPINB2, CMA1, ADA, CCL2
7MP:00053876.4CTSG, LBP, FCGR1A, SERPINB2, CMA1, MMP8

Publications for Peritonitis

About this section

Articles related to Peritonitis:

(show top 50)    (show all 4223)
idTitleAuthorsYear
1
Sepsis is associated with altered cerebral microcirculation and tissue hypoxia in experimental peritonitis*. (24196192)
2014
2
Effect of Initial Empiric Antibiotic Therapy Combined with Control of the Infection Focus on the Prognosis of Patients with Secondary Peritonitis. (25397738)
2014
3
Predictive factors that influence the survival rates in liver cirrhosis patients with spontaneous bacterial peritonitis. (23837137)
2013
4
Acute chylous peritonitis: Report of a case. (23500748)
2013
5
Zinc transporter 5 and zinc transporter 7 induced by high glucose protects peritoneal mesothelial cells from undergoing apoptosis. (23275032)
2013
6
Effect of chloroquine on feline infectious peritonitis virus infection in vitro and in vivo. (23648708)
2013
7
Spontaneous bacterial peritonitis in Dakar, Senegal: study of 55 patients with cirrhosis. (24317300)
2013
8
PD-L1 on tumor cells is induced in ascites and promotes peritoneal dissemination of ovarian cancer through CTL dysfunction. (23340297)
2013
9
Gangrenous appendicitis presenting as acute abdominal pain in a patient on automated peritoneal dialysis: a case report. (22989294)
2012
10
A case of cell-free and concentrated ascites reinfusion therapy effective for refractory ascites in spontaneous bacterial peritonitis in a renal transplant patient. (23289021)
2012
11
Peritonitis caused by Haemophilus parainfluenzae, Leifsonia aquatica, and Gordonia spp. in a patient undergoing continuous ambulatory peritoneal dialysis. (23268614)
2012
12
Recurrent acute pancreatitis in a patient on peritoneal dialysis using 7.5% icodextrin. (22991018)
2012
13
Giant and multiple jejunal diverticula presenting as peritonitis a significant challenging disorder. (23049633)
2012
14
Patients with peritoneal mesothelioma lack epidermal growth factor receptor tyrosine kinase mutations that would make them sensitive to tyrosine kinase inhibitors. (22426987)
2012
15
Spontaneous bacterial peritonitis: a rare mimic of acute appendicitis. (22510192)
2012
16
Multidrug resistance gene (MDR-1) and risk of brain metastasis in epithelial ovarian, fallopian tube, and peritoneal cancer. (20921883)
2011
17
The influence of risk factors in remodelling carotid arteries in patients undergoing peritoneal dialysis. (20433437)
2010
18
Peroxisome-proliferator activator receptor-gamma activation decreases attachment of endometrial cells to peritoneal mesothelial cells in an in vitro model of the early endometriotic lesion. (19643817)
2009
19
Disseminated cryptococcosis with meningitis, peritonitis, and cryptococcemia in a HIV-negative patient with cirrhosis: a case report. (19946481)
2009
20
Vascular cell adhesion molecule-1 is a regulator of ovarian cancer peritoneal metastasis. (19208843)
2009
21
Combination chemotherapy with cisplatin and gemcitabine in malignant peritoneal mesothelioma. (19593622)
2009
22
Lipid disorders, statins and the peritoneal membrane. (19494612)
2009
23
The TIMP-1 gene transferred through adenovirus mediation shows a suppressive effect on peritoneal metastases from gastric cancer. (17380436)
2007
24
Paclitaxel, carboplatin and pegylated liposomal doxorubicin in ovarian and peritoneal carcinoma: a phase I study of the Gynecologic Oncology Group. (16959305)
2007
25
The effect of pH-neutral peritoneal dialysis fluids on adipokine secretion from cultured adipocytes. (17132702)
2007
26
Education and imaging. Gastrointestinal: malignant peritoneal mesothelioma. (16911701)
2006
27
Immunohistochemical analysis of peritoneal mesothelioma and primary and secondary serous carcinoma of the peritoneum: antibodies to estrogen and progesterone receptors are useful. (16482993)
2006
28
Effects of human peritoneal mesothelial cells on angiogenesis factor expression and secretion of ovarian carcinoma cells]. (17366783)
2006
29
Peritoneal tuberculosis mimicking advanced ovarian cancer: a retrospective review of 22 cases. (16740297)
2006
30
Inhibitory effect of Buthus martensi Karsch extracts on interleukin-1beta-induced expression of nitric oxide (NO) synthase and production of NO in human chondrocytes and LPS-induced NO and prostaglandin E2 production in mouse peritoneal macrophages. (15963682)
2005
31
Observations on salpingitis, peritonitis and salpingoperitonitis in a layer breeder flock. (16272543)
2005
32
Primary peritoneal malignant mixed mA1llerian tumor associated with colonic adenocarcinoma. (16285567)
2005
33
Peritoneal fluid concentrations of interleukin-17 correlate with the severity of endometriosis and infertility of this disorder. (16045534)
2005
34
Treatment of terminal peritoneal carcinomatosis by a transducible p53-activating peptide. (14966535)
2004
35
Gemcitabine and cisplatin chemotherapy is an active combination in the treatment of platinum-resistant ovarian and peritoneal carcinoma. (15292718)
2004
36
Increased pregnancy-associated plasma protein-A (PAPP-A) concentrations in peritoneal fluid of women with endometriosis. (12765344)
2003
37
Peritoneal carcinoma in a male patient. (12759547)
2003
38
Effects of pentoxifylline on peritoneal fibroblasts and silica-induced peritoneal fibrosis. (12938822)
2003
39
Positive emission tomography for evaluating a complete clinical response in patients with ovarian or peritoneal carcinoma: correlation with second-look laparotomy. (11426956)
2001
40
Rapid quantitative detection of carcinoembryonic antigen-expressing free tumor cells in the peritoneal cavity of gastric-cancer patients with real-time RT-PCR on the lightcycler. (11008202)
2000
41
Therapy of acute variceal hemorrhage and spontaneous bacterial peritonitis in liver cirrhosis]. (9789469)
1998
42
Effects of bio-normalizer (a food supplementation) on free radical production by human blood neutrophils, erythrocytes, and rat peritoneal macrophages. (8748224)
1995
43
Regulation of equine fibrinolysis in blood and peritoneal fluid based on a study of colic cases and induced endotoxaemia. (7889922)
1994
44
Fibrinolytic activity of ascites caused by alcoholic cirrhosis and peritoneal malignancy. (8174965)
1993
45
Release of tumor necrosis factor alpha by human peritoneal macrophages in response to toxic shock syndrome toxin-1. (2067760)
1991
46
Studies of peritoneal macrophage function in murine systemic lupus erythematosus. 2. Nature of elevated resident peritoneal cells in NZB and (NZB x NZW)F1 mice. (3861745)
1985
47
Peritonitis in a patient with hepatorenal syndrome. (6731713)
1984
48
Tuberculous peritonitis. (515768)
1979
49
Gonococcal vulvovaginitis and possible peritonitis in prepubertal girls. (4996392)
1971
50
Tuberculous peritonitis treated with streptomycin. (14779387)
1950

Variations for Peritonitis

About this section

Expression for genes affiliated with Peritonitis

About this section
Search GEO for disease gene expression data for Peritonitis.

Pathways for genes affiliated with Peritonitis

About this section

Pathways related to Peritonitis according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CCL2, CD14
2
Show member pathways
9.6CTSG, CMA1
3
Show member pathways
9.3CD14, LBP
49.3FCGR3B, FCGR1A, CD14
5
Show member pathways
9.1CTSG, MMP8, CMA1
6
Show member pathways
9.1CMA1, MMP8, CTSG
79.0CTSG, CD14, SERPINB2
8
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.0CD14, CCL2, LBP
9
Show member pathways
8.8TBP, MMP8, FCGR1A, FCGR3B
10
Show member pathways
8.8CTSG, TBP, FCGR1A, FCGR3B
118.5CD14, FCGR1A, FCGR3B, LBP

Compounds for genes affiliated with Peritonitis

About this section

Compounds related to Peritonitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1hypoxanthine44 24 1111.9CD14, TBP, ADA
2vitamin b12449.9ADA, ALB, CCL2
3zidovudine44 50 1111.8ALB, ADA, CCL2
4monophosphoryl lipid a449.6CD14, LBP
5tositumomab50 1110.6FCGR1A, FCGR3B
6tetracycline44 1110.5ALB, MMP8, CCL2
7nitroblue tetrazolium449.5SERPINB2, CD14, FCGR1A
8vitamin d449.5CCL2, ALB, TBP, CD14
9sodium dodecylsulfate449.4CCL2, ALB, TBP, CTSG
10polysulfone449.4CD14, ALB, LBP
11prednisolone44 28 1111.4CD14, ALB, FCGR1A, FCGR3B
12scca1449.4CMA1, CTSG, SERPINB2
13polymyxin b449.3CD14, CCL2, LBP
14lipoteichoic acid449.3LBP, CD14, CCL2
15xanthine44 2410.3CD14, CTSG, ADA, MMP8
16leukotriene b444 60 2411.2CCL2, FCGR3B, CTSG
17glutamine449.2TBP, CD14, CCL2, FCGR1A, ADA
18peptidoglycan44 2810.1LBP, CD14, CTSG
19homocysteine44 2410.1LBP, CD14, ALB, CCL2
20lactate448.9CD14, ADA, ALB, CTSG, MMP8
21genistein44 28 60 1 24 1113.9FCGR3B, FCGR1A, MMP8, CCL2
22polyacrylamide448.8CTSG, CD14, LBP, TBP
23histamine44 28 2410.8CMA1, CCL2, CD14, ADA, ALB, CTSG
24cyclosporin a44 28 6010.7ADA, CD14, SERPINB2, MMP8
25paraffin448.7CTSG, SERPINB2, CMA1, CD14, CCL2
26vegf448.7SERPINB2, ADA, MMP8, CD14, CCL2
27pge2448.6FCGR1A, SERPINB2, MMP8, CCL2, CD14
28fmlp448.6CD14, FCGR3B, CCL2, CTSG, ADA, FCGR1A
29arachidonic acid44 28 24 1111.6CTSG, ALB, FCGR1A, LBP
30actinomycin d448.5SERPINB2, CCL2, LBP, FCGR1A
31polysaccharide448.4LBP, FCGR3B, CTSG, CD14, CCL2
32creatinine448.3LBP, CTSG, CD14, ALB, CCL2, ADA
33aspartate448.3LBP, ALB, CD14, ADA, CTSG, CCL2
34cholesterol44 28 24 1111.3CD14, CCL2, CMA1, FCGR1A, LBP, ALB
35cysteine448.3CD14, TBP, CTSG, ALB, MMP8, CMA1
36endotoxin448.3SERPINB2, LBP, CD14, CCL2, CTSG
37retinoic acid44 249.3MMP8, TBP, CD14, CTSG, SERPINB2, ADA
38hydrogen44 249.2SERPINB2, CTSG, MMP8, TBP
39h2o2448.1FCGR1A, CTSG, MMP8, FCGR3B, SERPINB2, ADA
40oxygen44 249.0MMP8, LBP, TBP, FCGR1A, CCL2
41heparin44 28 24 1111.0CTSG, CMA1, SERPINB2, ALB, CD14, LBP
42nitric oxide44 24 119.9SERPINB2, CCL2, CTSG, MMP8, LBP
43alanine447.9ADA, LBP, TBP, ALB, MMP8, CTSG
44cycloheximide447.8CD14, CTSG, SERPINB2, CCL2, FCGR1A, LBP
45dexamethasone44 50 28 1110.8CCL2, TBP, CD14, ADA, SERPINB2, FCGR1A
46fibrinogen447.1MMP8, SERPINB2, CCL2, ALB, CTSG, LBP
47calcium44 50 24 1110.0FCGR1A, SERPINB2, FCGR3B, CCL2, ALB, CD14
48superoxide44 247.9MMP8, FCGR1A, CD14, SERPINB2, CTSG, LBP
49lipid446.6CD14, ALB, CCL2, MMP8, FCGR3B, LBP
50serine446.2CTSG, FCGR3B, SERPINB2, MMP8, LBP, CMA1

GO Terms for genes affiliated with Peritonitis

About this section

Cellular components related to Peritonitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099868.5CTSG, CD14, ADA, LBP
2extracellular spaceGO:00056156.5LBP, SERPINB2, MMP8, ADA, CCL2, ALB
3extracellular regionGO:00055766.1CTSG, LBP, FCGR3B, SERPINB2, CMA1, MMP8

Biological processes related to Peritonitis according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1angiotensin maturationGO:00020039.8CTSG, CMA1
2response to heatGO:00094089.7CCL2, CD14
3cellular response to lipoteichoic acidGO:00712239.6CD14, LBP
4lipopolysaccharide-mediated signaling pathwayGO:00316639.4CCL2, LBP
5positive regulation of tumor necrosis factor productionGO:00327609.3CD14, LBP
6negative regulation of growth of symbiont in hostGO:00441309.3CTSG, LBP
7extracellular matrix disassemblyGO:00226179.3CMA1, MMP8, CTSG
8cellular response to lipopolysaccharideGO:00712229.2CD14, CCL2, LBP
9proteolysisGO:00065089.2CMA1, MMP8, CTSG
10immune responseGO:00069559.1CTSG, FCGR1A, FCGR3B
11extracellular matrix organizationGO:00301988.8CTSG, MMP8, CMA1

Molecular functions related to Peritonitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:00198649.5FCGR1A, FCGR3B
2lipoteichoic acid bindingGO:00708919.3CD14, LBP
3serine-type endopeptidase activityGO:00042529.1CTSG, MMP8, CMA1
4lipopolysaccharide bindingGO:00015309.0CD14, LBP

Sources for Peritonitis

About this section
2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet