MCID: PRV004
MIFTS: 53

Periventricular Leukomalacia

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Periventricular Leukomalacia

MalaCards integrated aliases for Periventricular Leukomalacia:

Name: Periventricular Leukomalacia 12 72 49 50 55 28 14
Leukomalacia, Periventricular 41 69
Leukomalacia Periventricular 51
Pvl 49

Classifications:

Orphanet: 55  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:13088
ICD10 32 P91.2
ICD9CM 34 779.7
MeSH 41 D007969
NCIt 46 C99013
SNOMED-CT 64 230769007
Orphanet 55 ORPHA171676
MESH via Orphanet 42 D007969
UMLS via Orphanet 70 C0023529
UMLS 69 C0023529

Summaries for Periventricular Leukomalacia

NINDS : 50 Periventricular leukomalacia (PVL) is characterized by the death of the white matter of the brain due to softening of the brain tissue. It can affect fetuses or newborns; premature babies are at the greatest risk of the disorder. PVL is caused by a lack of oxygen or blood flow to the periventricular area of the brain, which results in the death or loss of brain tissue. The periventricular area-the area around the spaces in the brain called ventricles-contains nerve fibers that carry messages from the brain to the body's muscles. Although babies with PVL generally have no outward signs or symptoms of the disorder, they are at risk for motor disorders, delayed mental development, coordination problems, and vision and hearing impairments. PVL may be accompanied by a hemorrhage or bleeding in the periventricular-intraventricular area (the area around and inside the ventricles), and can lead to cerebral palsy. The disorder is diagnosed by ultrasound of the head.

MalaCards based summary : Periventricular Leukomalacia, also known as leukomalacia, periventricular, is related to brain injury and listeriosis. An important gene associated with Periventricular Leukomalacia is MYT1 (Myelin Transcription Factor 1), and among its related pathways/superpathways are Toll Comparative Pathway and Tuberculosis. The drugs Dopamine and Levodopa have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and heart, and related phenotypes are homeostasis/metabolism and cellular

NIH Rare Diseases : 49 Periventricular leukomalacia (PVL) is a brain injury disorder characterized by the death of the white matter of the brain due to softening of the brain tissue. It can affect fetuses or newborns, and premature babies are at the greatest risk of the disorder. PVL is caused by a lack of oxygen or blood flow to the area around the ventricles of the brain, which results in the death of brain tissue. Although babies with PVL generally have no apparent signs or symptoms of the disorder at delivery, they are at risk for motor disorders, cerebral palsy, delayed mental development, coordination problems, and vision and hearing impairments.There is no cure for PVL. Treatment is generally supportive. Prognosis is dependent on the extent of damage to the ventricles. Last updated: 3/22/2016

Wikipedia : 72 Periventricular leukomalacia (PVL) is a form of white-matter brain injury, characterized by the necrosis... more...

Related Diseases for Periventricular Leukomalacia

Diseases related to Periventricular Leukomalacia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
# Related Disease Score Top Affiliating Genes
1 brain injury 30.5 EPO IL6 MBP
2 listeriosis 30.3 IL6 TNF
3 leukomalacia 28.0 ALOX15 EPO IL1R1 IL6 MBP MYT1
4 proliferative verrucous leukoplakia 11.5
5 fetal indomethacin syndrome 11.2
6 cerebritis 10.6
7 scorpion envenomation 10.5 IL6 TNF
8 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL6 TNF
9 critical limb ischemia 10.5 IL6 TNF
10 streptococcal toxic-shock syndrome 10.5 IL6 TNF
11 null-cell leukemia 10.5 IL6 TNF
12 retinitis pigmentosa 55 10.5 IL6 TNF
13 glossitis 10.5 IL6 TNF
14 laryngitis 10.5 IL6 TNF
15 cerebral palsy 10.5
16 anterior uveitis 10.5 IL6 TNF
17 vibrio vulnificus infection 10.5 EPO IL6
18 acute vascular insufficiency of intestine 10.4 IL6 TNF
19 posterior urethral valves 10.4 IL6 TNF
20 microscopic colitis 10.4 IL6 TNF
21 meconium aspiration syndrome 10.4 IL6 TNF
22 arteriovenous fistula 10.4 EPO IL6
23 hydrocephalus due to congenital stenosis of aqueduct of sylvius 10.4 MBP NES
24 burning mouth syndrome 10.4 IL6 TNF
25 central nervous system vasculitis 10.4 IL6 TNF
26 osteosclerotic myeloma 10.4 IL6 TNF
27 stachybotrys chartarum 10.4 IL6 TNF
28 acute monoblastic leukemia 10.4 EPO IL6
29 louse-borne relapsing fever 10.4 IL6 TNF
30 transient arthritis 10.4 IL6 MBP
31 aging 10.3
32 neuronitis 10.3
33 crimean-congo hemorrhagic fever 10.3 IL6 TNF
34 spasticity 10.3
35 ischemic heart disease 10.3 IL6 TNF
36 transverse myelitis 10.3 IL6 MBP TNF
37 myelitis 10.3 IL6 MBP TNF
38 viral encephalitis 10.3 IL6 MBP TNF
39 poems syndrome 10.3 EPO IL6 TNF
40 intermediate uveitis 10.3 IL6 TNF
41 relapsing-remitting multiple sclerosis 10.3 IL6 MBP TNF
42 end stage renal failure 10.2 EPO IL6 TNF
43 urinary system disease 10.2 EPO IL6 TNF
44 acquired immunodeficiency syndrome 10.2 EPO IL6 TNF
45 immune system disease 10.2 EPO IL6 TNF
46 tympanosclerosis 10.2 NOS2 TNF
47 leukoplakia 10.2
48 hepatic encephalopathy 10.2 IL6 SLC1A2 TNF
49 west syndrome 10.2
50 spastic diplegia 10.2

Graphical network of the top 20 diseases related to Periventricular Leukomalacia:



Diseases related to Periventricular Leukomalacia

Symptoms & Phenotypes for Periventricular Leukomalacia

MGI Mouse Phenotypes related to Periventricular Leukomalacia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.96 MBP MYT1 NOS2 PDHA1 SLC1A2 TNF
2 cellular MP:0005384 9.92 ALOX15 EPO IL1R1 IL6 MBP NOS2
3 cardiovascular system MP:0005385 9.91 ALOX15 EPO IL1R1 IL6 NOS2 PDHA1
4 mortality/aging MP:0010768 9.9 ALOX15 CPVL EPO IL1R1 IL6 MBP
5 muscle MP:0005369 9.5 EPO IL1R1 IL6 MYT1 NOS2 PDHA1
6 neoplasm MP:0002006 9.02 ALOX15 IL1R1 IL6 NOS2 TNF

Drugs & Therapeutics for Periventricular Leukomalacia

Drugs for Periventricular Leukomalacia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 140)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 1 51-61-6, 62-31-7 681
2
Levodopa Approved Phase 4 59-92-7 6047
3
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4,Phase 3 7487-88-9 24083
4
Ibuprofen Approved Phase 4,Phase 3,Phase 1 15687-27-1 3672
5 Poractant alfa Approved Phase 4 129069-19-8
6
Indomethacin Approved, Investigational Phase 4,Phase 1,Phase 2 53-86-1 3715
7 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
8 Carbidopa, levodopa drug combination Phase 4
9 Dihydroxyphenylalanine Phase 4
10 Dopamine Agents Phase 4,Phase 3,Phase 1
11 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
12 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
13 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1
14 Analgesics Phase 4,Phase 3,Phase 1,Phase 2
15 Anesthetics Phase 4,Phase 3
16 Anti-Arrhythmia Agents Phase 4,Phase 3
17 Anticonvulsants Phase 4,Phase 3
18 calcium channel blockers Phase 4,Phase 3
19 Calcium, Dietary Phase 4,Phase 3
20 Central Nervous System Depressants Phase 4,Phase 3
21 Tocolytic Agents Phase 4,Phase 3,Phase 1,Phase 2
22 Pulmonary Surfactants Phase 4,Phase 3,Phase 2
23 Respiratory System Agents Phase 4,Phase 3,Phase 2
24 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 1,Phase 2
25 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 1,Phase 2
26 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 1,Phase 2
27 Antirheumatic Agents Phase 4,Phase 3,Phase 1,Phase 2
28 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 1,Phase 2
29
Phenobarbital Approved, Investigational Phase 3 50-06-6 4763
30
Progesterone Approved, Vet_approved Phase 2, Phase 3 57-83-0 5994
31
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
32
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
33 Simethicone Approved Phase 3
34
Benzocaine Approved, Investigational Phase 2, Phase 3 1994-09-7, 94-09-7 2337
35
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
36
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
37
Dalteparin Approved Phase 3 9005-49-6
38
Heparin Approved, Investigational Phase 3 9005-49-6 46507594 772
39
Betamethasone Approved, Vet_approved Phase 3 378-44-9 9782
40
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
41
Nitric Oxide Approved Phase 2, Phase 3 10102-43-9 145068
42 Beractant Approved Phase 2, Phase 3 108778-82-1
43 tannic acid Approved, Nutraceutical Phase 2, Phase 3
44
Caffeine Approved, Nutraceutical Phase 3 58-08-2 2519
45
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
46 Pharmaceutical Solutions Phase 3,Phase 2,Phase 1
47 Epoetin alfa Phase 3,Phase 1,Phase 2 113427-24-0
48 Hematinics Phase 3,Phase 1,Phase 2
49 Cytochrome P-450 CYP3A Inducers Phase 3
50 Excitatory Amino Acid Antagonists Phase 3

Interventional clinical trials:

(show top 50) (show all 72)

# Name Status NCT ID Phase Drugs
1 Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled Study Unknown status NCT01361373 Phase 4 L- DOPA;placebo
2 Neuroprotection by Magnesium Sulfate Given to Women at Risk of Very Preterm Birth Completed NCT00120588 Phase 4 magnesium
3 OPTIMIST-A Trial: Minimally-invasive Surfactant Therapy in Preterm Infants 25-28 Weeks Gestation on CPAP Recruiting NCT02140580 Phase 4
4 Comparing Ibuprofen And Indomethacin For The Treatment Of The Patent Ductus Arteriosus in Very Premature Babies Withdrawn NCT00470743 Phase 4 Ibuprofen;Indomethacin
5 Management of Hypotension In the Preterm Infant Unknown status NCT01482559 Phase 3 Dopamine hydrochloride;Dextrose 5%
6 Magnesium Sulfate to Prevent Brain Injury in Premature Infants Unknown status NCT00065949 Phase 3 magnesium sulfate
7 Tracheal Occlusion To Accelerate Lung Growth (TOTAL) Trial for Severe Pulmonary Hypoplasia Unknown status NCT01240057 Phase 2, Phase 3
8 Premature Infants in Need of Transfusion (PINT) Completed NCT00182390 Phase 3
9 Antenatal Phenobarbital to Prevent Neonatal Intracranial Hemorrhage Completed NCT00009620 Phase 3 Phenobarbital;Saline
10 Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial) Completed NCT00014989 Phase 3 magnesium sulfate
11 17OHP for Reduction of Neonatal Morbidity Due to Preterm Birth (PTB) in Twin and Triplet Pregnancies Completed NCT00163020 Phase 2, Phase 3 17-alpha-hydroxyprogesterone caproate injectable;Placebo
12 Fluconazole Prophylaxis for the Prevention of Candidiasis in Infants Less Than 750 Grams Birthweight Completed NCT00734539 Phase 3 fluconazole;placebo
13 NIV Strategies for RDS in Preterm Infants. NIV (Non Invasive Ventilation), RDS (Respiratory Distress Syndrome) Completed NCT02259400 Phase 2, Phase 3
14 Surfactant Positive Airway Pressure and Pulse Oximetry Trial Completed NCT00233324 Phase 3 Surfactant;Supplemental oxygen with target saturation of 85 to 89%;Supplemental oxygen with target saturation of 91 to 95%
15 Caffeine for Apnea of Prematurity (CAP) Completed NCT00182312 Phase 3 Caffeine citrate injection
16 Pentoxifylline and Late Onset Sepsis in Preterm Infants Completed NCT02163174 Phase 3 Pentoxifylline (PTX);Placebo
17 High Versus Low Dose of Caffeine for Apnea of Prematurity Completed NCT02103777 Phase 3 Caffeine citrate
18 Safety and Efficacy Study of Ibuprofen l-Lysine Solution in Premature Infants for Treatment of PDA Completed NCT00440804 Phase 3 ibuprofen l-lysine iv solution (NeoProfen (R) )
19 Omega-3 Fatty Acid Supplementation to Prevent Preterm Birth in High Risk Pregnancies Completed NCT00135902 Phase 3 17 alpha-Hydroxyprogesterone Caproate and Omega-3 fish oils
20 Trial of Aggressive Versus Conservative Phototherapy in Infants <1,000 Grams Birth Weight Completed NCT00114543 Phase 3
21 Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS) Completed NCT00099164 Phase 3 17 alpha-hydroxyprogesterone caproate (17P)
22 Prevention of Maternal and Perinatal Complications by Enoxaparin in Women With Previous Severe Preeclampsia Completed NCT00986765 Phase 3 Lovenox® (enoxaparin);Aspegic ® (Aspirin)
23 Effect of Erythropoietin in Premature Infants on White Matter Lesions and Neurodevelopmental Outcome Recruiting NCT03110341 Phase 3 Erythropoietin;Normal saline
24 Dose Reduction of Antenatal Betamethasone Given to Prevent the Neonatal Complications Associated With Very Preterm Birth Recruiting NCT02897076 Phase 3 betamethasone 24 mg;12mg betamethasone +placebo
25 Maternal Omega-3 Supplementation to Reduce Bronchopulmonary Dysplasia Recruiting NCT02371460 Phase 3
26 Inhaled Nitric Oxide and Neuroprotection in Premature Infants Active, not recruiting NCT00515281 Phase 2, Phase 3 inhaled nitric oxide;oxygen
27 Efficacy and Safety of Goat Lung Surfactant for the Treatment of Respiratory Distress Syndrome in Preterm Neonates Not yet recruiting NCT02774044 Phase 2, Phase 3 Cadisurf;Survanta
28 Probiotics for the Prevention of Premature Birth and Neonatal Related Morbidity Terminated NCT00303082 Phase 3 Lactobacillus rhamnosus GR1 and Lactobacillus reuteri RC-14
29 Minimal Breathing Support and Early Steroids to Prevent Chronic Lung Disease in Extremely Premature Infants (SAVE) Terminated NCT00005777 Phase 3 Dexamethasone;Placebo
30 Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants Unknown status NCT00910234 Phase 1, Phase 2 recombinant human erythropoietin (rhEpo);recombinant human erythropoietin (rhEpo);Normal saline
31 Minimally Invasive Surfactant Therapy Followed by CPAP (MISTCPAP) in Preterm Infants With RDS Unknown status NCT01723683 Phase 2 Surfactant
32 High-frequency Oscillatory Ventilation (HFOV) in Preterm Infants With Severe Respiratory Distress Syndrome (RDS) Completed NCT01496508 Phase 2
33 Does Erythropoietin Improve Outcome in Very Preterm Infants? Completed NCT00413946 Phase 2 Recombinant human Erythropoietin;saline
34 Effects of Delayed Cord Clamp and/or Indomethacin on Preterm Infant Brain Injury Recruiting NCT02221219 Phase 1, Phase 2 Indomethacin;placebo infusion
35 Randomized Trial of Maternal Progesterone Therapy Recruiting NCT02133573 Phase 2 Progesterone;Vaginal lubricant
36 Antibiotic "Dysbiosis" in Preterm Infants Recruiting NCT02784821 Phase 2 Antibiotic;Antibiotics - pre-emptive
37 'TOTAL' (Tracheal Occlusion To Accelerate Lung Growth) Trial Recruiting NCT02875860 Phase 2
38 Probiotics Reduce Incidence of Necrotizing Enterocolitis for Very Low Birth Weight Infants Terminated NCT00540033 Phase 2
39 Dobutamine in the Treatment of Haemodynamic Insufficiency in the Immediate Postnatal Period Terminated NCT03311178 Phase 1, Phase 2 Dobutamine
40 High-Dose Erythropoietin in Extremely Premature Infants to Prevent/Attenuate Brain Injury: A Phase II Study Terminated NCT00589953 Phase 2 Erythropoietin;Saline placebo
41 A Trial of Infant Flow Biphasic Nasal Continuous Airway Pressure (NCPAP) Versus Infant Flow NCPAP for the Facilitation of Extubation in Infants </= 1250 Grams Terminated NCT00308789 Phase 2
42 Feasibility Study of Aerosolized Surfaxin in the Prevention of Respiratory Distress Syndrome (RDS) in Premature Infants Terminated NCT00807235 Phase 2 Aerosolized lucinactant;Aerosolized lucinactant
43 Early Blood Pressure Management in Extremely Premature Infants Completed NCT00874393 Phase 1 Dopamine;Hydrocortisone;Infusion Placebo;Syringe Placebo
44 Combination of Acetaminophen and Ibuprofen in the Management of Patent Ductus Arteriosus Recruiting NCT03103022 Phase 1 Acetaminophen;ibuprofen
45 S100B as a Marker of Brain Injury of Preterm Infants Unknown status NCT02082535
46 Use of Blended Oxygen for Delivery Room Resuscitation of Very Low Birth Weight Infants Unknown status NCT00369720
47 Telerehabilitation of Working Memory in Children With Periventricular Leukomalacia and Bilateral Cerebral Palsy Completed NCT02342990
48 Umbilical Cord Blood Proteomic Analysis and Neonatal Brain Injury Completed NCT00375908
49 Neonatal Outcome by Reason for Delivery Completed NCT01818518
50 Placental Transfusion Project for Preterm Infants Completed NCT02400697

Search NIH Clinical Center for Periventricular Leukomalacia

Cochrane evidence based reviews: leukomalacia, periventricular

Genetic Tests for Periventricular Leukomalacia

Genetic tests related to Periventricular Leukomalacia:

# Genetic test Affiliating Genes
1 Periventricular Leukomalacia 28

Anatomical Context for Periventricular Leukomalacia

MalaCards organs/tissues related to Periventricular Leukomalacia:

38
Brain, Lung, Heart, Cortex, Thalamus, Pons, Endothelial

Publications for Periventricular Leukomalacia

Articles related to Periventricular Leukomalacia:

(show top 50) (show all 397)
# Title Authors Year
1
Neuronalinjury and roles of apoptosis and autophagy in a neonatal rat model of hypoxia-ischemia-induced periventricular leukomalacia. ( 29436652 )
2018
2
Congenital Cytomegalovirus Infection and the Occurrence of Cystic Periventricular Leukomalacia. ( 29217314 )
2018
3
Outcome of Preterm Infants with Transient Cystic Periventricular Leukomalacia on Serial Cranial Imaging Up to Term Equivalent Age. ( 29398046 )
2018
4
Upper Limb Function, Kinematic Analysis, and Dystonia Assessment in Children With Spastic Diplegic Cerebral Palsy and Periventricular Leukomalacia. ( 28776460 )
2017
5
A model of Periventricular Leukomalacia (PVL) in neonate mice with histopathological and neurodevelopmental outcomes mimicking human PVL in neonates. ( 28406931 )
2017
6
Pathophysiology of periventricular leukomalacia: What we learned from animal models. ( 29239318 )
2017
7
Association between perinatal hypoxic-ischemia and periventricular leukomalacia in preterm infants: A systematic review and meta-analysis. ( 28931047 )
2017
8
Periventricular leukomalacia with -16 DS high myopia in a 2A1 months old infant: A rare case presentation. ( 29118507 )
2017
9
Neuroprotective effects of human umbilical cord-derived mesenchymal stem cells on periventricular leukomalacia-like brain injury in neonatal rats. ( 29259700 )
2017
10
Intranasal surfactant protein D as neuroprotective rescue in a neonatal rat model of periventricular leukomalacia. ( 27109442 )
2016
11
Quality of Life of Children with Cystic Periventricular Leukomalacia - A Prospective Analysis with the Child Health Questionnaire-Parent Form 50. ( 27242979 )
2016
12
The association between pro- and anti-inflammatory cytokine polymorphisms and periventricular leukomalacia in newborns with hypoxic-ischemic encephalopathy. ( 27217792 )
2016
13
Periventricular leukomalacia in a neonatal calf. ( 27010465 )
2016
14
The vulnerability of thalamocortical circuitry to hypoxic-ischemic injury in a mouse model of periventricular leukomalacia. ( 26733225 )
2016
15
Isolated Cystic Periventricular Leukomalacia Differs from Cystic Periventricular Leukomalacia with Intraventricular Hemorrhage in Prevalence, Risk Factors and Outcomes in Preterm Infants. ( 27643988 )
2016
16
Slow pupillary light responses in infants at high risk of cerebral palsy were associated with periventricular leukomalacia and neurological outcome. ( 27468114 )
2016
17
Diffusion-Weighted Imaging of Periventricular Leukomalacia in Very Young Children: Assessment of Peritrigonal Stripe of Restricted Diffusion. ( 28030870 )
2016
18
Relation between prognosis and changes of MBP and S100B in premature infants with periventricular leukomalacia. ( 25966206 )
2015
19
Corticospinal Tract Injury Precedes Thalamic Volume Reduction in Preterm Infants with Cystic Periventricular Leukomalacia. ( 26054943 )
2015
20
Two important factors affecting the transition to breastfeeding in preterm infants: corrected age and periventricular leukomalacia. ( 26265900 )
2015
21
The whole spectrum of cystic periventricular leukomalacia of the preterm infant: results from a large consecutive case series. ( 26099229 )
2015
22
Relationship between white matter integrity and severity of motor impairment in children with cerebral palsy caused by periventricular leukomalacia. ( 26531639 )
2015
23
Scoring system for periventricular leukomalacia in infants with congenital heart disease. ( 25996891 )
2015
24
Bioinformatics analyses combined microarray identify the differentially expressed microRNAs in periventricular leukomalacia. ( 26812286 )
2015
25
Antenatal exposure to indomethacin increases the risk of severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia: a systematic review with metaanalysis. ( 25448524 )
2015
26
Impact of risk factors other than prematurity on periventricular leukomalacia. A population-based matched case control study. ( 25748489 )
2015
27
Chloride cotransporter NKCC1 inhibitor bumetanide protects against white matter injury in a rodent model of periventricular leukomalacia. ( 25585037 )
2015
28
The Effects of the Severity of Periventricular Leukomalacia on the Neuropsychological Outcomes of Preterm Children. ( 26385973 )
2015
29
Increased fetal heart rate variability in periventricular leukomalacia. ( 26338690 )
2015
30
Screening Cranial Imaging at Multiple Time Points Improves Cystic Periventricular Leukomalacia Detection. ( 25730135 )
2015
31
Clinical study of cerebral palsy in 408 children with periventricular leukomalacia. ( 25780432 )
2015
32
Latency after preterm prelabor rupture of the membranes: increased risk for periventricular leukomalacia. ( 25136457 )
2014
33
Retinal vessel pathologies in a rat model of periventricular leukomalacia: a new model for retinopathy of prematurity? ( 25698709 )
2014
34
Visual Evoked Potentials in Infants with Diffuse Periventricular Leukomalacia. ( 24615931 )
2014
35
Severe cystic periventricular leukomalacia in a premature infant with capnocytophaga sepsis. ( 25452885 )
2014
36
Diffusion tensor imaging-demonstrated differences between hemiplegic and diplegic cerebral palsy with symmetric periventricular leukomalacia. ( 22976239 )
2013
37
Using the Alberta Infant Motor Scale to early identify very low-birth-weight infants with cystic periventricular leukomalacia. ( 21959127 )
2013
38
Epileptic Encephalopathy With Continuous Spike and Wave During Sleep Associated to Periventricular Leukomalacia. ( 24293309 )
2013
39
Texture analysis of periventricular echogenicity on neonatal cranial ultrasound predicts periventricular leukomalacia. ( 24246513 )
2013
40
Risk factors for preoperative periventricular leukomalacia in term neonates with hypoplastic left heart syndrome are patient related. ( 23879933 )
2013
41
Differences between periventricular hemorrhagic infarction and periventricular leukomalacia. ( 23978489 )
2013
42
Ischemia-induced neuroinflammation is associated with disrupted development of oligodendrocyte progenitors in a model of periventricular leukomalacia. ( 23445614 )
2013
43
Spontaneous movements in the supine position of healthy term infants and preterm infants with or without periventricular leukomalacia. ( 22656321 )
2013
44
Neurodevelopmental outcomes of children with periventricular leukomalacia. ( 23727042 )
2013
45
Visuospatial working memory in toddlers with a history of periventricular Leukomalacia: an EEG narrow-band power analysis. ( 23922816 )
2013
46
12/15-lipoxygenase expression is increased in oligodendrocytes and microglia of periventricular leukomalacia. ( 23838566 )
2013
47
Preterm twin and triplet pregnancies are at increased risk for the development of cystic periventricular leukomalacia. ( 22795624 )
2013
48
Periventricular leukomalacia and less invasive surfactant administration in extremely preterm infants. Concerning the article by k. Klebermass-schrehof et Al.: less invasive surfactant administration in extremely preterm infants: impact on mortality and morbidity [neonatology 2013;103:252-258]. ( 23817316 )
2013
49
Diphenyleneiodonium protects preoligodendrocytes against endotoxin-activated microglial NADPH oxidase-generated peroxynitrite in a neonatal rat model of periventricular leukomalacia. ( 23174417 )
2013
50
Epilepsy in children with periventricular leukomalacia. ( 23891141 )
2013

Variations for Periventricular Leukomalacia

ClinVar genetic disease variations for Periventricular Leukomalacia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 RPS6KC1 NM_001287219.2(RPS6KC1): c.2074G> A (p.Gly692Ser) single nucleotide variant Likely pathogenic rs61751035 GRCh38 Chromosome 1, 213242186: 213242186
2 RPS6KC1 NC_000001.10: g.(?_213396378)_(213592823_?)del deletion Likely pathogenic GRCh37 Chromosome 1, 213396378: 213592823
3 MCOLN1 NM_020533.2(MCOLN1): c.378C> G (p.Tyr126Ter) single nucleotide variant Likely pathogenic rs1057518782 GRCh37 Chromosome 19, 7591465: 7591465
4 MCOLN1 NM_020533.2(MCOLN1): c.777+1G> C single nucleotide variant Likely pathogenic rs1057518781 GRCh38 Chromosome 19, 7527961: 7527961

Expression for Periventricular Leukomalacia

Search GEO for disease gene expression data for Periventricular Leukomalacia.

Pathways for Periventricular Leukomalacia

Pathways related to Periventricular Leukomalacia according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.03 IL1R1 IL6 NOS2 TNF
2 12 IL6 NOS2 TNF
3 11.95 IL6 NOS2 TNF
4
Show member pathways
11.92 IL1R1 IL6 NOS2 TNF
5 11.76 EPO IL6 TNF
6 11.68 ALOX15 IL6 NOS2 TNF
7 11.57 IL6 NOS2 TNF
8 11.56 EPO IL6 NOS2 PDHA1
9 11.49 IL6 NOS2 TNF
10
Show member pathways
11.45 IL6 NOS2 TNF
11 11.44 EPO IL1R1 IL6 TNF
12 11.32 IL1R1 IL6 TNF
13 11.24 IL1R1 IL6 NOS2 TNF
14 11.11 EPO NOS2 PDHA1
15 11.1 IL1R1 IL6 MBP NOS2 TNF
16 11.05 IL6 TNF
17 10.89 IL6 TNF
18 10.82 IL6 TNF

GO Terms for Periventricular Leukomalacia

Biological processes related to Periventricular Leukomalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.67 IL1R1 IL6 MBP TNF
2 cellular response to lipopolysaccharide GO:0071222 9.43 IL6 NOS2 TNF
3 positive regulation of chemokine production GO:0032722 9.32 IL6 TNF
4 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.16 ALOX15 TNF
5 negative regulation of lipid storage GO:0010888 8.96 IL6 TNF
6 response to salt stress GO:0009651 8.62 EPO TNF

Molecular functions related to Periventricular Leukomalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.8 IL1R1 MBP TNF

Sources for Periventricular Leukomalacia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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