MCID: PRX077
MIFTS: 39

Peroxisomal Biogenesis Disorders malady

Categories: Rare diseases, Genetic diseases

Aliases & Classifications for Peroxisomal Biogenesis Disorders

Aliases & Descriptions for Peroxisomal Biogenesis Disorders:

Name: Peroxisomal Biogenesis Disorders 50
Peroxisome Biogenesis Disorders 24 29 52 69
Disorders of Peroxisome Biogenesis 50

Classifications:



Summaries for Peroxisomal Biogenesis Disorders

MalaCards based summary : Peroxisomal Biogenesis Disorders, also known as peroxisome biogenesis disorders, is related to peroxisome biogenesis disorder 11b and heimler syndrome 1. An important gene associated with Peroxisomal Biogenesis Disorders is PEX6 (Peroxisomal Biogenesis Factor 6), and among its related pathways/superpathways is Peroxisome. The drugs Cyclophosphamide and Busulfan have been mentioned in the context of this disorder. Affiliated tissues include brain, ovary and testes, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Peroxisomal Biogenesis Disorders

Diseases related to Peroxisomal Biogenesis Disorders via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
id Related Disease Score Top Affiliating Genes
1 peroxisome biogenesis disorder 11b 34.0 PEX1 PEX13
2 heimler syndrome 1 31.9 CAT HSD17B4 PEX1 PEX10 PEX12 PEX2
3 peroxisome biogenesis disorder 5a 12.5
4 peroxisome biogenesis disorder 4a 12.5
5 peroxisome biogenesis disorder 2a 12.5
6 peroxisome biogenesis disorder 12a 12.5
7 peroxisome biogenesis disorder 11a 12.5
8 peroxisome biogenesis disorder 9b 12.5
9 peroxisome biogenesis disorder 10a 12.5
10 peroxisome biogenesis disorder 6a 12.4
11 peroxisome biogenesis disorder 8a, 12.4
12 peroxisome biogenesis disorder 7a 12.4
13 peroxisome biogenesis disorder 1b 12.4
14 peroxisome biogenesis disorder 14b 12.4
15 peroxisome biogenesis disorder 3a 12.4
16 peroxisome biogenesis disorder 1a 12.4
17 peroxisome biogenesis disorder 13a 12.4
18 peroxisome biogenesis disorder 6b 12.4
19 peroxisome biogenesis disorder 5b 12.4
20 peroxisome biogenesis disorder 8b 12.4
21 peroxisome biogenesis disorder 4b 12.4
22 peroxisome biogenesis disorder 7b 12.4
23 peroxisome biogenesis disorder 2b 12.4
24 peroxisome biogenesis disorder 3b 12.4
25 peroxisome biogenesis disorders, zellweger syndrome spectrum 12.3
26 zellweger syndrome 11.8
27 chondrodysplasia punctata, rhizomelic, type 1 11.8
28 heimler syndrome 2 11.7
29 adrenoleukodystrophy 11.3
30 refsum disease, infantile form 11.2
31 refsum disease 10.9
32 chondrodysplasia punctata, rhizomelic, type 2 10.9
33 chondrodysplasia punctata, rhizomelic, type 3 10.9
34 deafness progressive cataract autosomal dominant 10.3 PEX1 PEX6
35 bardet-biedl syndrome 15 10.2 PEX1 PEX13
36 growth hormone deficiency, isolated, type ii 10.2 PEX1 PEX5 PEX7
37 bardet-biedl syndrome 5 10.2 PEX5 PEX7
38 doughnut lesions of skull, familial 10.1 PEX5 PEX7
39 holoprosencephaly 6 10.1 PEX5 PEX7 PHEX
40 mental retardation, autosomal recessive 44 10.1 CAT HSD17B4 PEX5
41 spinocerebellar ataxia, autosomal recessive 13 10.1 HSD17B4 PEX7
42 chronic polyradiculoneuritis 10.1 ABCD1 BCAP31
43 langer mesomelic dwarfism 10.0 PEX2 PEX6
44 spinocerebellar ataxia, x-linked 1 10.0 ABCD1 BCAP31
45 muscular dystrophy, congenital, 1b 9.9 CAT PEX5 PEX7 PHEX
46 diabetes, mellitus, insulin-dependent 10 9.8 CAT PEX1 PEX2 PEX5 PEX6 PEX7
47 neuronitis 9.8
48 peroxisome disorders 9.8
49 ataxia 9.8
50 usher syndrome 9.8

Graphical network of the top 20 diseases related to Peroxisomal Biogenesis Disorders:



Diseases related to Peroxisomal Biogenesis Disorders

Symptoms & Phenotypes for Peroxisomal Biogenesis Disorders

MGI Mouse Phenotypes related to Peroxisomal Biogenesis Disorders:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.97 ABCD1 HSD17B4 PEX10 PEX13 PEX2 PEX5
2 growth/size/body region MP:0005378 9.96 PEX2 PEX3 PEX5 PEX7 PHEX F2R
3 homeostasis/metabolism MP:0005376 9.93 PEX13 PEX2 PEX3 PEX5 PEX7 PHEX
4 liver/biliary system MP:0005370 9.5 F2R HSD17B4 PEX1 PEX13 PEX2 PEX5
5 nervous system MP:0003631 9.32 ABCD1 F2R HSD17B4 PEX1 PEX10 PEX13

Drugs & Therapeutics for Peroxisomal Biogenesis Disorders

Drugs for Peroxisomal Biogenesis Disorders (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 90)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
2
Busulfan Approved, Investigational Phase 2, Phase 3 55-98-1 2478
3
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
4
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
5
Glycerol Approved, Experimental Phase 2, Phase 3 56-81-5 753
6
Betaine Approved, Nutraceutical Phase 3 107-43-7 247
7
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
8
Biotin Approved, Nutraceutical Phase 2, Phase 3 58-85-5 171548
9 Prednisolone acetate Phase 2, Phase 3
10 Alkylating Agents Phase 2, Phase 3
11 Cholic Acids Phase 3
12 Gastrointestinal Agents Phase 3
13 Trace Elements Phase 2, Phase 3,Phase 1
14 Vitamin B Complex Phase 2, Phase 3
15 Vitamins Phase 2, Phase 3,Phase 1
16 Hypolipidemic Agents Phase 3
17 Prednisolone hemisuccinate Phase 2, Phase 3
18 Prednisolone phosphate Phase 2, Phase 3
19 Immunosuppressive Agents Phase 2, Phase 3
20 Antilymphocyte Serum Phase 2, Phase 3
21 Liver Extracts Phase 3
22 Lipid Regulating Agents Phase 3
23 Antimetabolites Phase 3,Phase 2
24 Methylprednisolone acetate Phase 2, Phase 3
25 Methylprednisolone Hemisuccinate Phase 2, Phase 3
26 Micronutrients Phase 2, Phase 3,Phase 1
27 Antirheumatic Agents Phase 2, Phase 3
28 Antineoplastic Agents, Alkylating Phase 2, Phase 3
29 Bile Acids and Salts Phase 3
30 Pharmaceutical Solutions Phase 2, Phase 3
31 Folate Nutraceutical Phase 2, Phase 3
32 Vitamin B9 Nutraceutical Phase 2, Phase 3
33 Vitamin B7 Nutraceutical Phase 2, Phase 3
34
Cyclosporine Approved, Investigational, Vet_approved Phase 2 79217-60-0, 59865-13-3 5284373 6435893
35
Melphalan Approved Phase 2 148-82-3 4053 460612
36
Mycophenolic acid Approved Phase 2 24280-93-1 446541
37
Mycophenolate mofetil Approved, Investigational Phase 2 128794-94-5 5281078
38
Hydroxyurea Approved Phase 2 127-07-1 3657
39
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
40
alemtuzumab Approved, Investigational Phase 2 216503-57-0
41
Clofarabine Approved, Investigational Phase 2 123318-82-1 119182
42
Benzocaine Approved Phase 2 1994-09-7, 94-09-7 2337
43
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
44
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
45
Fludarabine Approved Phase 2 21679-14-1, 75607-67-9 30751
46
rituximab Approved Phase 2 174722-31-7 10201696
47
Thiotepa Approved Phase 2 52-24-4 5453
48
Mesna Approved Phase 2 3375-50-6 598
49 tannic acid Approved, Nutraceutical Phase 2
50
Vitamin E Approved, Nutraceutical, Vet_approved Phase 2 59-02-9 14985

Interventional clinical trials:

(show all 39)
id Name Status NCT ID Phase
1 Compassionate Treatment of Patients With Inborn Errors of Bile Acid Metabolism With Cholic Acid Completed NCT00007020 Phase 3
2 Betaine and Peroxisome Biogenesis Disorders Completed NCT01838941 Phase 3
3 Stem Cell Transplant for Inborn Errors of Metabolism Completed NCT00176904 Phase 2, Phase 3
4 A Phase 2/3 Study of the Efficacy and Safety of Hematopoietic Stem Cells Transduced With Lenti-D Lentiviral Vector for the Treatment of Cerebral Adrenoleukodystrophy (CALD) Recruiting NCT01896102 Phase 2, Phase 3
5 MD1003-AMN MD1003 in Adrenomyeloneuropathy Active, not recruiting NCT02961803 Phase 2, Phase 3
6 Effect of Glycerol Trierucate on Clinical Course of Adrenoleukodystrophy Suspended NCT00004418 Phase 2, Phase 3
7 A Phase III Trial of Lorenzo's Oil in Adrenomyeloneuropathy Terminated NCT00545597 Phase 3
8 HSCT for High Risk Inherited Inborn Errors Completed NCT00383448 Phase 2
9 A Clinical Trial for AMN: Validation of Biomarkers of Oxidative Stress, Efficacy and Safety of a Mixture of Antioxidants Completed NCT01495260 Phase 2
10 Canakinumab in Patients With Active Hyper-IgD Syndrome Completed NCT01303380 Phase 2
11 MT2013-31: Allo HCT for Metabolic Disorders and Severe Osteopetrosis Recruiting NCT02171104 Phase 2
12 A Pilot Study of Vitamin D in Boys With X-linked Adrenoleukodystrophy Recruiting NCT02595489 Phase 1, Phase 2
13 Autologous Hematopoietic Stem Cell Gene Therapy for Metachromatic Leukodystrophy and Adrenoleukodystrophy Recruiting NCT02559830 Phase 1, Phase 2
14 Allogeneic Bone Marrow Transplant for Inherited Metabolic Disorders Active, not recruiting NCT01043640 Phase 2
15 Phase I/II Pilot Study of Mixed Chimerism to Treat Inherited Metabolic Disorders Active, not recruiting NCT01372228 Phase 1, Phase 2
16 Hematopoietic Stem Cell Transplantation (HCT) for Inborn Errors of Metabolism Terminated NCT00668564 Phase 2
17 UCB Transplant of Inherited Metabolic Diseases With Administration of Intrathecal UCB Derived Oligodendrocyte-Like Cells Recruiting NCT02254863 Phase 1
18 Human Placental-Derived Stem Cell Transplantation Recruiting NCT01586455 Phase 1
19 MT2014-14 IT-MSC for Advanced Cerebral Adrenoleukodystrophy (cALD) Withdrawn NCT02410239 Phase 1
20 Safety and Pharmacodynamic Study of Sobetirome in X-Linked Adrenoleukodystrophy (X-ALD) Withdrawn NCT01787578 Phase 1
21 Study of Protein Translocation in Patients With Beta-Oxidation Disorders Unknown status NCT00004348
22 Dietary Cholesterol and Defects in Cholesterol Synthesis in Mevalonate Kinase Deficiency Unknown status NCT00260299
23 B7 Coreceptor Molecules in Hyper IgD Syndrome Form of Mevalonate Kinase Deficiency Unknown status NCT01568736
24 Clinical Study and Gene Mutation Analysis of Adrenoleukodystrophy in Taiwanese Children Unknown status NCT00278044
25 Study of Pulmonary Complications in Pediatric Patients With Storage Disorders Undergoing Allogeneic Hematopoietic Stem Cell Transplantation Unknown status NCT00005900
26 Reduced-Intensity Hematopoietic Stem Cell Transplant for High Risk Lysosomal and Peroxisomal Disorders Completed NCT01626092
27 Exercise Study of Function and Pathology for Women With X-linked Adrenoleukodystrophy Completed NCT01594853
28 The Effect of Bezafibrate on the Level of Very Long Chain Fatty Acids (VLCFA) in X-linked Adrenoleukodystrophy (X-ALD) Completed NCT01165060
29 Randomized Study of Beta Interferon and Thalidomide in Patients With Adrenoleukodystrophy Completed NCT00004450
30 Longitudinal Natural History Study of Patients With Peroxisome Biogenesis Disorders (PBD) Recruiting NCT01668186
31 Newborn Screening for Adrenoleukodystrophy Recruiting NCT02952482
32 Inherited Retinal Degenerative Disease Registry Recruiting NCT02435940
33 Observational Study to Evaluate Allogeneic HSCT Outcomes for Cerebral Adrenoleukodystrophy (CALD) Recruiting NCT02204904
34 Expanded Access for Lorenzo's Oil (GTO/GTE) in Adrenoleukodystrophy Available NCT02233257
35 Long-term Follow-up of Subjects With Cerebral Adrenoleukodystrophy Who Were Treated With Lenti-D Drug Product Enrolling by invitation NCT02698579
36 Evaluation of a New Strategy for the Diagnosis of Peroxisomal Diseases Not yet recruiting NCT03163771
37 The Replace Registry Not yet recruiting NCT03115086
38 Early Diagnosis Of Childhood Cerebral ALD Not yet recruiting NCT02948062
39 Study of Bile Acids in Patients With Peroxisomal Disorders Terminated NCT00004442

Search NIH Clinical Center for Peroxisomal Biogenesis Disorders

Genetic Tests for Peroxisomal Biogenesis Disorders

Genetic tests related to Peroxisomal Biogenesis Disorders:

id Genetic test Affiliating Genes
1 Peroxisome Biogenesis Disorders 29
2 Peroxisome Biogenesis Disorders (pbd) 24 PEX6

Anatomical Context for Peroxisomal Biogenesis Disorders

MalaCards organs/tissues related to Peroxisomal Biogenesis Disorders:

39
Brain, Ovary, Testes

Publications for Peroxisomal Biogenesis Disorders

Articles related to Peroxisomal Biogenesis Disorders:

(show top 50) (show all 89)
id Title Authors Year
1
Expanding the spectrum of PEX10-related peroxisomal biogenesis disorders: slowly progressive recessive ataxia. ( 27230853 )
2016
2
Peroxisome biogenesis disorders in the Zellweger spectrum: An overview of current diagnosis, clinical manifestations, and treatment guidelines. ( 26750748 )
2016
3
Peripheral nervous system defects in a mouse model for peroxisomal biogenesis disorders. ( 25176044 )
2014
4
Peroxisome biogenesis disorders: Biological, clinical and pathophysiological perspectives. ( 23798008 )
2013
5
Zellweger syndrome - a lethal peroxisome biogenesis disorder. ( 23327810 )
2013
6
Peroxisome biogenesis disorders: molecular basis for impaired peroxisomal membrane assembly: in metabolic functions and biogenesis of peroxisomes in health and disease. ( 22705440 )
2012
7
If at first you don't succeed, test again (for peroxisomal biogenesis disorders). ( 22459679 )
2012
8
Genetics and molecular basis of human peroxisome biogenesis disorders. ( 22871920 )
2012
9
Molecular basis of peroxisomal biogenesis disorders caused by defects in peroxisomal matrix protein import. ( 22617146 )
2012
10
First PEX11I^ patient extends spectrum of peroxisomal biogenesis disorder phenotypes. ( 22581969 )
2012
11
Characterization of two common 5' polymorphisms in PEX1 and correlation to survival in PEX1 peroxisome biogenesis disorder patients. ( 21846392 )
2011
12
A Drosophila model for the Zellweger spectrum of peroxisome biogenesis disorders. ( 21669930 )
2011
13
Lymphoblastoid cell lines for diagnosis of peroxisome biogenesis disorders. ( 23430824 )
2011
14
alpha-Synuclein abnormalities in mouse models of peroxisome biogenesis disorders. ( 19830841 )
2010
15
A mutation in PEX19 causes a severe clinical phenotype in a patient with peroxisomal biogenesis disorder. ( 20683989 )
2010
16
Identification of an unusual variant peroxisome biogenesis disorder caused by mutations in the PEX16 gene. ( 20647552 )
2010
17
Identification of novel mutations and sequence variation in the Zellweger syndrome spectrum of peroxisome biogenesis disorders. ( 19105186 )
2009
18
Urine acylcarnitine analysis by ESI-MS/MS: a new tool for the diagnosis of peroxisomal biogenesis disorders. ( 18793625 )
2008
19
A novel PEX12 mutation identified as the cause of a peroxisomal biogenesis disorder with mild clinical phenotype, mild biochemical abnormalities in fibroblasts and a mosaic catalase immunofluorescence pattern, even at 40 degrees C. ( 17534573 )
2007
20
Peroxisome biogenesis disorders. ( 17055079 )
2006
21
Mutations in the Peroxin Pex26p Responsible for Peroxisome Biogenesis Disorders of Complementation Group 8 Impair Its Stability, Peroxisomal Localization, and Interaction with the Pex1p.Pex6p Complex. ( 16257970 )
2006
22
Molecular and neurologic findings of peroxisome biogenesis disorders. ( 15921234 )
2005
23
PEX1 mutations in the Zellweger spectrum of the peroxisome biogenesis disorders. ( 16086329 )
2005
24
Peroxisome biogenesis disorders: the role of peroxisomes and metabolic dysfunction in developing brain. ( 15868469 )
2005
25
Molecular mechanism of a temperature-sensitive phenotype in peroxisomal biogenesis disorder. ( 16006427 )
2005
26
An overview of peroxisomal biogenesis disorders. ( 15875330 )
2005
27
Peroxisomal disorders I: biochemistry and genetics of peroxisome biogenesis disorders. ( 15679822 )
2005
28
Novel mutations in the PEX2 gene of four unrelated patients with a peroxisome biogenesis disorder. ( 14630978 )
2004
29
Peroxisome biogenesis disorders with prolonged survival: phenotypic expression in a cohort of 31 patients. ( 15098231 )
2004
30
The PEX Gene Screen: molecular diagnosis of peroxisome biogenesis disorders in the Zellweger syndrome spectrum. ( 15542397 )
2004
31
Reinvestigation of trihydroxycholestanoic acidemia reveals a peroxisome biogenesis disorder. ( 15184617 )
2004
32
Novel mutations in the PEX12 gene of patients with a peroxisome biogenesis disorder. ( 14571262 )
2004
33
Identification of a new complementation group of the peroxisome biogenesis disorders and PEX14 as the mutated gene. ( 15146459 )
2004
34
Neuroimaging of peroxisome biogenesis disorders (Zellweger spectrum) with prolonged survival. ( 14872027 )
2004
35
Lessons from knockout mice. I: Phenotypes of mice with peroxisome biogenesis disorders. ( 14713222 )
2003
36
Genetic heterogeneity in Japanese patients with peroxisome biogenesis disorders and evidence for a founder haplotype for the most common mutation in PEX10 gene. ( 14713216 )
2003
37
Genetic heterogeneity of peroxisome biogenesis disorders among Japanese patients: evidence for a founder haplotype for the most common PEX10 gene mutation. ( 12794690 )
2003
38
Modeling human peroxisome biogenesis disorders in the nematode Caenorhabditis elegans. ( 12665560 )
2003
39
Disturbances of valine metabolism in patients with peroxisomal biogenesis disorders. ( 14713217 )
2003
40
Mutations in novel peroxin gene PEX26 that cause peroxisome- biogenesis disorders of complementation group 8 provide a genotype- phenotype correlation. ( 12851857 )
2003
41
Biochemical markers predicting survival in peroxisome biogenesis disorders. ( 14713214 )
2003
42
Is there a phenotype/genotype correlation in peroxisome biogenesis disorders (PBDs)? ( 14713213 )
2003
43
Cellular and molecular aspects of Zellweger syndrome and other peroxisome biogenesis disorders. ( 12169017 )
2002
44
Novel PEX1 mutations and genotype-phenotype correlations in Australasian peroxisome biogenesis disorder patients. ( 12402331 )
2002
45
A PEX6-defective peroxisomal biogenesis disorder with severe phenotype in an infant, versus mild phenotype resembling Usher syndrome in the affected parents. ( 11873320 )
2002
46
Biochemical markers predicting survival in peroxisome biogenesis disorders. ( 12473763 )
2002
47
Contiguous deletion of the X-linked adrenoleukodystrophy gene (ABCD1) and DXS1357E: a novel neonatal phenotype similar to peroxisomal biogenesis disorders. ( 11992258 )
2002
48
Pex13, the mouse ortholog of the human peroxisome biogenesis disorder PEX13 gene: gene structure, tissue expression, and localization of the protein to peroxisomes. ( 11829486 )
2002
49
Phenotype-genotype relationships in peroxisome biogenesis disorders of PEX1-defective complementation group 1 are defined by Pex1p-Pex6p interaction. ( 11439091 )
2001
50
Genetic and molecular bases of peroxisome biogenesis disorders. ( 11545691 )
2001

Variations for Peroxisomal Biogenesis Disorders

Expression for Peroxisomal Biogenesis Disorders

Search GEO for disease gene expression data for Peroxisomal Biogenesis Disorders.

Pathways for Peroxisomal Biogenesis Disorders

Pathways related to Peroxisomal Biogenesis Disorders according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.36 ABCD1 CAT HSD17B4 PEX1 PEX10 PEX12

GO Terms for Peroxisomal Biogenesis Disorders

Cellular components related to Peroxisomal Biogenesis Disorders according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peroxisome GO:0005777 9.77 ABCD1 CAT HSD17B4 PEX1 PEX10 PEX12
2 integral component of peroxisomal membrane GO:0005779 9.63 ABCD1 PEX10 PEX12 PEX13 PEX2 PEX3
3 peroxisomal matrix GO:0005782 9.56 CAT HSD17B4 PEX7 PIPOX
4 peroxisomal membrane GO:0005778 9.36 ABCD1 CAT HSD17B4 PEX1 PEX10 PEX12
5 membrane GO:0016020 10.17 ABCD1 BCAP31 CAT F2R HSD17B4 PEX1

Biological processes related to Peroxisomal Biogenesis Disorders according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 protein transport GO:0015031 9.92 BCAP31 PEX1 PEX13 PEX5 PEX7
2 neuron migration GO:0001764 9.67 PEX13 PEX5 PEX7
3 fatty acid beta-oxidation GO:0006635 9.65 ABCD1 HSD17B4 PEX2 PEX5 PEX7
4 peroxisome organization GO:0007031 9.61 ABCD1 PEX1 PEX10 PEX12 PEX2 PEX3
5 fatty acid beta-oxidation using acyl-CoA oxidase GO:0033540 9.51 ABCD1 HSD17B4
6 alpha-linolenic acid metabolic process GO:0036109 9.48 ABCD1 HSD17B4
7 very long-chain fatty acid metabolic process GO:0000038 9.46 HSD17B4 PEX2
8 protein targeting to peroxisome GO:0006625 9.46 PEX1 PEX12 PEX6 PEX7
9 cerebral cortex cell migration GO:0021795 9.43 PEX13 PEX5
10 protein import into peroxisome membrane GO:0045046 9.4 PEX3 PEX5
11 protein import into peroxisome matrix, docking GO:0016560 9.37 PEX13 PEX5
12 microtubule-based peroxisome localization GO:0060152 9.32 PEX1 PEX13
13 protein import into peroxisome matrix GO:0016558 9.1 PEX1 PEX10 PEX12 PEX2 PEX5 PEX7

Molecular functions related to Peroxisomal Biogenesis Disorders according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.46 CAT F2R HSD17B4 PIPOX
2 protein C-terminus binding GO:0008022 9.43 PEX1 PEX12 PEX6
3 enzyme binding GO:0019899 9.26 ABCD1 CAT PEX5 PEX7
4 ATPase activity, coupled GO:0042623 8.62 PEX1 PEX6

Sources for Peroxisomal Biogenesis Disorders

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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