Aliases & Classifications for Persian Gulf Syndrome

MalaCards integrated aliases for Persian Gulf Syndrome:

Name: Persian Gulf Syndrome 12 41 14 69
Gulf War Syndrome 12 51

External Ids:

Disease Ontology 12 DOID:4491
MeSH 41 D018923
SNOMED-CT 64 95877004
UMLS 69 C0282550

Summaries for Persian Gulf Syndrome

Disease Ontology : 12 A syndrome affecting returning military veterans and civilian workers of the Gulf War.

MalaCards based summary : Persian Gulf Syndrome, also known as gulf war syndrome, is related to alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity and autonomic dysfunction. An important gene associated with Persian Gulf Syndrome is ADCYAP1 (Adenylate Cyclase Activating Polypeptide 1), and among its related pathways/superpathways is G alpha (s) signalling events. The drugs Doxycycline and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include liver.

Wikipedia : 72 Gulf War syndrome (GWS), also known as Gulf War illnesses (GWI) and chronic multisymptom illness (CMI),... more...

Related Diseases for Persian Gulf Syndrome

Diseases related to Persian Gulf Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0
2 autonomic dysfunction 10.0
3 multiple chemical sensitivity 9.9
4 chronic fatigue syndrome 9.9
5 dysautonomia 9.9
6 holoprosencephaly 3 9.8 ADCYAP1 VIP
7 migraine with or without aura 1 9.7 ADCYAP1 VIP
8 pheochromocytoma 9.6 ADCYAP1 VIP

Graphical network of the top 20 diseases related to Persian Gulf Syndrome:



Diseases related to Persian Gulf Syndrome

Symptoms & Phenotypes for Persian Gulf Syndrome

Drugs & Therapeutics for Persian Gulf Syndrome

Drugs for Persian Gulf Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 79)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 3 564-25-0 54671203
2 Anti-Infective Agents Phase 3,Phase 1
3 Anti-Bacterial Agents Phase 3
4 Antibiotics, Antitubercular Phase 3
5 Antimalarials Phase 3
6 Antiparasitic Agents Phase 3
7 Antiprotozoal Agents Phase 3
8 Antitubercular Agents Phase 3
9
Menthol Approved Phase 1, Phase 2 2216-51-5 16666
10
Coal tar Approved Phase 1, Phase 2 8007-45-2
11
Curcumin Approved, Investigational Phase 1, Phase 2 458-37-7 969516
12 Antioxidants Phase 2,Phase 1
13 Peripheral Nervous System Agents Phase 1, Phase 2
14 Analgesics Phase 1, Phase 2
15 Analgesics, Non-Narcotic Phase 1, Phase 2
16 Anti-Inflammatory Agents Phase 1, Phase 2
17 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
18 Antirheumatic Agents Phase 1, Phase 2
19 Lactoferrin Phase 2
20 Muramidase Phase 2
21 Pharmaceutical Solutions Phase 2
22
Lactulose Approved Phase 1 4618-18-2 11333
23
Rifaximin Approved, Investigational Phase 1 80621-81-4 6436173
24
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
25
Niacin Approved, Investigational, Nutraceutical Phase 1 59-67-6 938
26
Nicotinamide Approved, Investigational, Nutraceutical Phase 1 98-92-0 936
27 Gastrointestinal Agents Phase 1
28 Nucleic Acid Synthesis Inhibitors Phase 1
29 Antimetabolites Phase 1
30 Hypolipidemic Agents Phase 1
31 Lipid Regulating Agents Phase 1
32 Micronutrients Phase 1
33 Nicotinic Acids Phase 1
34 Trace Elements Phase 1
35 Vasodilator Agents Phase 1
36 Vitamin B Complex Phase 1
37 Vitamins Phase 1
38 Folate Nutraceutical Phase 1
39 Vitamin B3 Nutraceutical Phase 1
40 Vitamin B9 Nutraceutical Phase 1
41
Naltrexone Approved, Investigational, Vet_approved 16590-41-3 5360515
42
Dobutamine Approved 34368-04-2 36811
43
Ephedrine Approved 299-42-3 9294
44
Oxymetazoline Approved, Investigational 1491-59-4 4636
45
Phenylephrine Approved 59-42-7 6041
46
Pseudoephedrine Approved 90-82-4 7028
47
Resveratrol Approved, Experimental, Investigational 501-36-0 445154
48 Cod liver oil Approved, Vet_approved
49
Glutamic Acid Approved, Nutraceutical 56-86-0 33032
50
St. John's Wort Approved, Investigational, Nutraceutical 84082-80-4

Interventional clinical trials:

(show all 30)

# Name Status NCT ID Phase Drugs
1 Exercise and Behavioral Therapy Trial (EBT). Completed NCT00007748 Phase 3
2 Antibiotic Treatment of Gulf War Veterans' Illnesses Completed NCT00007735 Phase 3 Doxycycline (200mg/day) or Placebo
3 rTMS for the Treatment of Chronic Pain in GW1 Veterans Terminated NCT01608321 Phase 3
4 Acupuncture in the Treatment of Gulf War Illness Completed NCT01305811 Phase 1, Phase 2
5 Treatment Study of Carnosine Versus Placebo in Gulf War Illness (GWI) Completed NCT00810368 Phase 2 Carnosine;Placebo
6 Clinical Benefits of a Novel Sleep-focused Mind-body Program on Gulf War Illness (GWI) Symptoms Completed NCT01543997 Phase 2
7 Glutathione vs. Curcumin Clinical Trial Recruiting NCT02848417 Phase 1, Phase 2 Curcumin;Glutathione
8 Scalp Application of Red and Near-Infrared Light, From Light-Emitting Diodes (LED) to Improve Thinking and Memory in Veterans With Gulf War Illnesses Recruiting NCT01782378 Phase 2
9 Gulf War Illness Nasal Irrigation Study Active, not recruiting NCT01700725 Phase 2 Nasal Irrigation - Xylitol
10 Bacterial Overgrowth Associated With Chronic Multisymptom Illness Complex Unknown status NCT00956150 Phase 1 Rifaximin;Placebo
11 Gulf War Illness: Evaluation of an Innovative Detoxification Program Completed NCT01672710 Phase 1
12 Influenza Vaccination in Fibromyalgia Patients Unknown status NCT01465477
13 Mechanisms of Mitochondrial Defects in Gulf War Syndrome Completed NCT01264471
14 Mindfulness-Based Stress Reduction for Gulf War Syndrome Completed NCT01267045
15 Effects of Low Dose Naltrexone in Fibromyalgia Completed NCT00568555 Low Dose Naltrexone;Placebo - sugar pill
16 Sleep Disordered Breathing in Gulf War Illness and the Effect of Nasal CPAP Treatment Completed NCT00252629
17 Exercise in Gulf War Illness (GWI) Completed NCT01291758
18 Investigate Olfactory Functioning as a Possible Proxy for Neurotoxic Exposure in Cohorts of Deployed and Non-Deployed Gulf War-Era Veterans. Completed NCT00007514
19 Telemedicine Treatment for Veterans With Gulf War Illness Completed NCT00129454
20 Follow-up of Psychological and Neurocognitive Gulf War Outcome: Relation to Stress Completed NCT00018707
21 Sentra AM® and Sentra PM® for Post-traumatic Stress Disorder (PTSD) and Gulf War Fibromyalgia (GWF) Completed NCT01437891
22 Acupressure for Pain Management and Fatigue Relief in Gulf War Veterans Completed NCT02075489
23 Study of Gulf War Illness (GWI) by Comparing GWI and Healthy Veterans Completed NCT00810225
24 Characterization of Pain Processing Mechanisms in Irritable Bowel Syndrome Completed NCT00100425
25 Hyporeactivity and Gulf War Illness Completed NCT00100412 Graded dobutamine infusions;Graded phenylephrine injections
26 Glutamate Neuro-Excitotoxicity in GWI Recruiting NCT03342482
27 Alleviating Headache and Pain in GWI With Neuronavigation Guided rTMS Recruiting NCT03030794
28 Effects of Botanical Microglia Modulators in Gulf War Illness Recruiting NCT02909686
29 Mitochondrial Cocktail for Gulf War Illness Not yet recruiting NCT02804828
30 Gulf War 1 Veteran Healthcare Satisfaction Withdrawn NCT01703767

Search NIH Clinical Center for Persian Gulf Syndrome

Cochrane evidence based reviews: persian gulf syndrome

Genetic Tests for Persian Gulf Syndrome

Anatomical Context for Persian Gulf Syndrome

MalaCards organs/tissues related to Persian Gulf Syndrome:

38
Liver

Publications for Persian Gulf Syndrome

Articles related to Persian Gulf Syndrome:

# Title Authors Year
1
Cognitive performance and cerebrohemodynamics associated with the Persian Gulf Syndrome. ( 12479508 )
2001
2
Al Eskan disease: Persian Gulf syndrome. ( 9121655 )
1997
3
Al Eskan disease: Persian Gulf syndrome. ( 9002695 )
1997
4
Beef allergy and the Persian Gulf syndrome. ( 8569540 )
1995
5
NIH panel rejects Persian Gulf syndrome. ( 8164748 )
1994

Variations for Persian Gulf Syndrome

Expression for Persian Gulf Syndrome

Search GEO for disease gene expression data for Persian Gulf Syndrome.

Pathways for Persian Gulf Syndrome

Pathways related to Persian Gulf Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.79 ADCYAP1 VIP

GO Terms for Persian Gulf Syndrome

Biological processes related to Persian Gulf Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor signaling pathway GO:0007186 9.33 ADCYAP1 ARHGEF1 VIP
2 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 8.96 ADCYAP1 VIP
3 regulation of protein localization GO:0032880 8.62 ADCYAP1 VIP

Molecular functions related to Persian Gulf Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.96 ADCYAP1 VIP
2 neuropeptide hormone activity GO:0005184 8.62 ADCYAP1 VIP

Sources for Persian Gulf Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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