MCID: PRS049
MIFTS: 52

Persistent Mullerian Duct Syndrome malady

Categories: Genetic diseases, Rare diseases, Endocrine diseases, Reproductive diseases, Fetal diseases

Aliases & Classifications for Persistent Mullerian Duct Syndrome

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Aliases & Descriptions for Persistent Mullerian Duct Syndrome:

Name: Persistent Mullerian Duct Syndrome 11 46 13
Persistent Müllerian Duct Syndrome 24 25
Persistent Oviduct Syndrome 46 24
Pmds 46 24
Persistent Mullerian Duct Syndrome, Types 1 and 2 46
 
Female Genital Ducts in Otherwise Normal Male 46
Persistent Muellerian Duct Syndrome 11
Hernia Uteri Inguinale 46
Persistent M 37

Classifications:



External Ids:

Disease Ontology11 DOID:0050791
MeSH37 C536665
SNOMED-CT60 702358005
NCIt43 C120188

Summaries for Persistent Mullerian Duct Syndrome

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NIH Rare Diseases:46 Persistent müllerian duct syndrome (pmds) is a disorder of sexual development that affects males. affected males have normal male reproductive organs and normal male external genitalia, but also have a uterus and fallopian tubes (female reproductive organs). the uterus and fallopian tubes develop from a structure called the müllerian duct in the fetus, which normally breaks down in males. in males with pmds, the müllerian duct remains. early signs of pmds may include undescended testes (cryptorchidism) or inguinal hernias. the uterus and fallopian tubes are often noticed during surgery to treat these conditions. other features of pmds may include unusual or abnormal positioning of the testes and female reproductive organs; transverse testicular ectopia (when both testicles descend on the same side); and infertility. pmds is caused by mutations in the amh gene (pmds type 1) or amhr2 gene (pmds type 2) and is inherited in an autosomal recessive manner. in some cases, the genetic cause is unknown. treatment may involve surgery to place the testes within the scrotum and remove müllerian structures. last updated: 10/20/2015

MalaCards based summary: Persistent Mullerian Duct Syndrome, also known as persistent müllerian duct syndrome, is related to persistent mullerian duct syndrome, type ii and pelizaeus-merzbacher disease. An important gene associated with Persistent Mullerian Duct Syndrome is AMH (Anti-Mullerian Hormone), and among its related pathways are ALK2 signaling events and Glypican 3 network. Affiliated tissues include uterus, testes and cervix, and related mouse phenotypes are neoplasm and liver/biliary system.

Disease Ontology:11 A pseudohermaphroditism that is characterized by the persistence of mullerian duct derivatives (i.e. uterus, cervix, fallopian tubes and upper two thirds of vagina) in a phenotypically and karyotypically male.

Genetics Home Reference:24 Persistent Müllerian duct syndrome is a disorder of sexual development that affects males. Males with this disorder have normal male reproductive organs, though they also have a uterus and fallopian tubes, which are female reproductive organs. The uterus and fallopian tubes are derived from a structure called the Müllerian duct during development of the fetus. The Müllerian duct usually breaks down during early development in males, but it is retained in those with persistent Müllerian duct syndrome. Affected individuals have the normal chromosomes of a male (46,XY) and normal external male genitalia.

Related Diseases for Persistent Mullerian Duct Syndrome

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Diseases in the Persistent Mullerian Duct Syndrome family:

Persistent Mullerian Duct Syndrome, Type Ii

Diseases related to Persistent Mullerian Duct Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1persistent mullerian duct syndrome, type ii12.5
2pelizaeus-merzbacher disease11.8
3diabetes insipidus, nephrogenic10.6AMH, AMHR2
4gaucher's disease10.5AMH, AMHR2, SRY
5uremia10.5AMH, BMP15, SRY
6pleural empyema10.5AMH, AMHR2, BMP15
7hidradenitis10.4AMH, NR5A1, SRY
8eosinophilic meningitis10.4SRY, TGFB1
9tetraamelia with pulmonary hypoplasia10.4INSL3, NR5A1, SRY
10candidiasis10.4AMH, BMP15, SRY
11abca1-related disorders10.4NR5A1, SRY
12lateral sclerosis10.4AMH, BMP15, NR5A1
13seminoma10.3
14benign paroxysmal positional nystagmus10.3BMP15, NR5A1, SRY
15spermatogenic failure, y-linked, 110.3SOX9, SRY
16inguinal hernia10.3
17mite infestation10.2FGFR2, SRY
18diabetes mellitus, insulin-resistant, with acanthosis nigricans10.2AMH, INSL3, NR5A1
19cryptorchidism10.2
20farmer's lung10.1AMHR2, SOX9, SRY
21testicular seminoma10.1
22drug-induced vasculitis10.1NR5A1, SOX9, SRY
23premature ovarian failure 310.0BMP15, NR5A1
24mental retardation, x-linked 10110.0AMH, BMP15, NR5A1
2546 xx gonadal dysgenesis10.0NR5A1, SOX9, SRY
26hypospadias9.9
27klinefelter's syndrome9.9
28endometriosis9.9
29teratoma9.9
30pseudohermaphroditism9.9
31tuberculosis9.9
32meacham syndrome9.9AMH, NR5A1, SOX9, SRY
33nephrogenic adenofibroma9.8INSL3, KIT, SRY
34chromosome 16p11.2 deletion syndrome, 220kb9.8AMH, FGFR2, NOTCH2, PLP1
3548,xxxy syndrome9.8BMP15, NR5A1, SOX9, SRY
36tooth disease9.8INSL3, NR5A1, SOX9, SRY
37mixed gonadal dysgenesis9.6AMH, BMP15, NR5A1, SOX9, SRY
38lateral medullary syndrome9.6CTNNB1, KIT
39hyperbiliverdinemia9.6CTNNB1, NR5A1, SOX9, SRY
40hydronephrosis, congenital, with cleft palate, characteristic facies, hypotonia, and mental retardation9.5KIT, SOX9, SRY
41myasthenic syndrome, congenital, 2c, associated with acetylcholine receptor deficiency9.4BMP4, FGFR2, SOX9
42gallbladder papillomatosis9.4CTNNB1, KIT, TGFB1
43brachyolmia9.2CTNNB1, KIT, TGFB1
44multiple synostoses syndrome4.8AMH, AMHR2, BMP15, BMP4, BMP5, CTNNB1

Graphical network of the top 20 diseases related to Persistent Mullerian Duct Syndrome:



Diseases related to persistent mullerian duct syndrome

Symptoms for Persistent Mullerian Duct Syndrome

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Drugs & Therapeutics for Persistent Mullerian Duct Syndrome

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Persistent Mullerian Duct Syndrome


Cochrane evidence based reviews: persistent m

Genetic Tests for Persistent Mullerian Duct Syndrome

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Genetic tests related to Persistent Mullerian Duct Syndrome:

id Genetic test Affiliating Genes
1 Persistent Mullerian Duct Syndrome25

Anatomical Context for Persistent Mullerian Duct Syndrome

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MalaCards organs/tissues related to Persistent Mullerian Duct Syndrome:

34
Uterus, Testes, Cervix, Testis, Kidney

Animal Models for Persistent Mullerian Duct Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Persistent Mullerian Duct Syndrome:

39 (show all 26)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.9AMH, AMHR2, CTNNB1, FGFR2, KIT, NOTCH2
2MP:00053707.5BMP4, BMP5, CTNNB1, FGFR2, FURIN, KIT
3MP:00053777.4BMP4, BMP5, CTNNB1, FGFR2, KIT, PLP1
4MP:00030127.3AMH, AMHR2, BMP4, CTNNB1, FGFR2, KIT
5MP:00053827.2BMP4, BMP5, CTNNB1, FGFR2, KIT, NOTCH2
6MP:00053697.0BMP4, CTNNB1, FGFR2, KIT, NOTCH2, PLP1
7MP:00053886.9AMHR2, BMP4, BMP5, CTNNB1, FGFR2, KIT
8MP:00053876.8AMHR2, BMP5, CTNNB1, FGFR2, FURIN, KIT
9MP:00028736.8BMP4, CTNNB1, FGFR2, FURIN, KIT, NOTCH2
10MP:00107716.8AMHR2, BMP4, CTNNB1, FGFR2, FURIN, KIT
11MP:00053816.7BMP4, BMP5, CTNNB1, FGFR2, FURIN, KIT
12MP:00053676.6AMHR2, BMP4, BMP5, CTNNB1, FGFR2, KIT
13MP:00053846.6AMHR2, BMP4, CTNNB1, FGFR2, KIT, NOTCH2
14MP:00053716.6BMP4, BMP5, CTNNB1, FGFR2, FURIN, KIT
15MP:00053916.6BMP4, CTNNB1, FGFR2, KIT, NOTCH2, PLP1
16MP:00053976.5AMHR2, BMP4, CTNNB1, FGFR2, FURIN, KIT
17MP:00053906.2BMP4, BMP5, CTNNB1, FGFR2, INSL3, KIT
18MP:00053806.1AMHR2, BMP4, BMP5, CTNNB1, FGFR2, FURIN
19MP:00036316.1BMP4, CTNNB1, FGFR2, FURIN, KIT, NOTCH2
20MP:00053865.9BMP4, BMP5, CTNNB1, FGFR2, INSL3, KIT
21MP:00053855.9AMHR2, BMP4, BMP5, CTNNB1, FGFR2, FURIN
22MP:00053765.8AMH, AMHR2, BMP4, CTNNB1, FGFR2, KIT
23MP:00053785.6AMHR2, BMP4, BMP5, CTNNB1, FGFR2, FURIN
24MP:00107685.6AMHR2, BMP4, BMP5, CTNNB1, FGFR2, FURIN
25MP:00053795.5AMH, AMHR2, BMP15, BMP4, BMP5, CTNNB1
26MP:00053895.4AMH, AMHR2, BMP15, BMP4, BMP5, CTNNB1

Publications for Persistent Mullerian Duct Syndrome

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Articles related to Persistent Mullerian Duct Syndrome:

(show top 50)    (show all 63)
idTitleAuthorsYear
1
Persistent Mullerian Duct Syndrome with Embryonal Cell Carcinoma along with Ectopic Cross Fused Kidney. (26894123)
2016
2
Persistent mullerian duct syndrome: A 24-year experience. (27329391)
2016
3
Persistent Mullerian Duct Syndrome: a rare entity with a rare presentation in need of multidisciplinary management. (27532119)
2016
4
Persistent mullerian duct syndrome presenting as retractile testis with hypospadias: A rare entity. (27326401)
2016
5
Persistent Mullerian Duct Syndrome with Ovarian Endometriosis-A Rare Case Report. (27042476)
2016
6
Laparoscopic hysterectomy with bilateral orchidectomy for Persistent Mullerian duct syndrome with seminoma testes: Case report. (26622120)
2015
7
A case of testicular seminoma in persistent Mullerian duct syndrome with transverse testicular ectopia. (25504517)
2015
8
Acute urinary retention caused by seminoma in a case of persistent Mullerian duct syndrome. (25673601)
2015
9
Persistent Mullerian Duct Syndrome with Transverse Testicular Ectopia. (27512542)
2015
10
Laparoscopic management of transverse testicular ectopia with persistent mullerian duct syndrome. (26195884)
2015
11
A novel mutation of AMH in three siblings with persistent Mullerian duct syndrome. (26181047)
2015
12
Persistent mullerian duct syndrome: A case report and review of the literature. (25143891)
2014
13
Excision of Mullerian duct remnant for persistent Mullerian duct syndrome provides favorable short- and mid-term outcomes. (24594348)
2014
14
Persistent mullerian duct syndrome with transverse testicular ectopia: rare entity. (24783120)
2014
15
Robot-assisted Laparoscopic Hysterectomy, Gonadal Biopsy, and Orchiopexies in an Infant With Persistent Mullerian Duct Syndrome. (24246315)
2013
16
A novel mutation of anti-Mullerian hormone gene in Persistent Mullerian Duct Syndrome presented with bilateral cryptorchidism: a case report. (23611722)
2013
17
Persistent Mullerian duct syndrome with transverse testicular ectopia: rare presentation of inguinal hernia. (23801478)
2013
18
Indirect inguinal hernia with uterine tissue in a male: A case of persistent Mullerian duct syndrome and literature review. (23671501)
2013
19
Persistent Mullerian Duct Syndrome: an interesting case report. (24045516)
2013
20
Persistent mullerian duct syndrome in a patient with bilateral cryptorchid testes with seminoma. (23162363)
2012
21
Persistent mullerian duct syndrome in adult men diagnosed using laparoscopy. (21256537)
2011
22
Male form of persistent Mullerian duct syndrome type I (hernia uteri inguinalis) presenting as an obstructed inguinal hernia: a case report. (22185203)
2011
23
Persistent Mullerian duct syndrome with testicular seminoma: A report of two cases. (22022070)
2011
24
Transverse testicular ectopia and persistent Mullerian duct syndrome: video-assisted treatment. (19360556)
2010
25
Persistent Mullerian duct syndrome in a Miniature Schnauzer dog with signs of feminization and a Sertoli cell tumour. (18954385)
2010
26
Persistent Mullerian duct syndrome: a case-based algorithm. (20509098)
2010
27
Persistent mullerian duct syndrome. (20352001)
2010
28
Transverse testicular ectopia associated with persistent Mullerian duct syndrome - the role of imaging. (18559894)
2008
29
Three novel AMH gene mutations in a patient with persistent mullerian duct syndrome and normal AMH serum dosage. (18547961)
2008
30
Combined persistent Mullerian Duct Syndrome, Transverse Testicular Ectopia and Mosaic Klinefelter's Syndrome. (18760051)
2008
31
Tuberculosis of transverse testicular ectopic testis associated with persistent mullerian duct syndrome. (18474165)
2008
32
Persistent mullerian duct syndrome and transverse testicular ectopia: embryology, presentation, and management. (18082721)
2007
33
Persistent Mullerian duct syndrome with transverse testicular ectopia presenting in an irreducible recurrent inguinal hernia. (17902529)
2007
34
Persistent mullerian duct syndrome with transverse testicular ectopia. (17333518)
2007
35
Persistent Mullerian duct syndrome with bilateral abdominal testis: surgical approach and review of the literature. (18947583)
2005
36
Persistent mullerian duct syndrome with transverse testicular ectopia. (15730845)
2005
37
Persistent Mullerian duct syndrome associated with 47,XXY genotype. (14713842)
2004
38
Persistent Mullerian duct syndrome causing male pseudohermaphroditism in a mixed-breed dog. (15499815)
2004
39
Mutations of the anti-mullerian hormone gene in patients with persistent mullerian duct syndrome: biosynthesis, secretion, and processing of the abnormal proteins and analysis using a three-dimensional model. (14673134)
2004
40
Persistent Mullerian duct syndrome caused by both a 27-bp deletion and a novel splice mutation in the MIS type II receptor gene. (14745940)
2003
41
Persistent mullerian duct syndrome--a case report. (12675189)
2002
42
Persistent mullerian duct syndrome with teratoma in an ectopic testis: imaging features. (11419169)
2001
43
A case of bilateral seminoma in the setting of persistent mullerian duct syndrome. (11421115)
2001
44
Persistent Mullerian duct syndrome associated with transverse testicular ectopia. (11180784)
1999
45
Persistent mullerian duct syndrome with normal testis. (9670631)
1998
46
Persistent Mullerian Duct Syndrome associated with transverse testicular ectopia: a case report. (9085816)
1997
47
Persistent mullerian duct syndrome associated with transverse testicular ectopia. (17377436)
1997
48
A testicular tumour in the left adnex. The persistent mullerian duct syndrome with testicular malignancy. (1671659)
1991
49
Premature centromeric divisions and prominent telomeres in a patient with persistent mullerian duct syndrome. (1967991)
1990
50
Persistent Mullerian duct syndrome: report of two boys with associated crossed testicular ectopia. (2359010)
1990

Variations for Persistent Mullerian Duct Syndrome

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Expression for genes affiliated with Persistent Mullerian Duct Syndrome

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Search GEO for disease gene expression data for Persistent Mullerian Duct Syndrome.

Pathways for genes affiliated with Persistent Mullerian Duct Syndrome

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Pathways related to Persistent Mullerian Duct Syndrome according to GeneCards Suite gene sharing:

(show all 27)
idSuper pathwaysScoreTop Affiliating Genes
110.1AMH, AMHR2
29.7BMP4, FURIN
39.4CTNNB1, FURIN, NOTCH2
4
Show member pathways
9.4BMP4, BMP5, TGFB1
5
Show member pathways
9.3BMP4, FURIN, TGFB1
69.3CTNNB1, SOX9, SRY
79.2BMP4, CTNNB1, TGFB1
89.2BMP4, NOTCH2, SOX9
9
Show member pathways
9.1CTNNB1, NR5A1, SOX9, WNT7A
109.0BMP4, KIT, TGFB1
11
Show member pathways
9.0AMH, AMHR2, BMP4, BMP5, TGFB1
12
Show member pathways
9.0FGFR2, NOTCH2, TGFB1
138.9CTNNB1, FGFR2, TGFB1
14
Show member pathways
8.8BMP4, CTNNB1, KIT, WNT7A
158.7BMP15, BMP4, BMP5, CTNNB1, TGFB1
168.7AMHR2, BMP4, CTNNB1, NOTCH2, TGFB1
178.6BMP4, BMP5, FGFR2, TGFB1
188.6AMH, BMP4, BMP5, CTNNB1, TGFB1, WNT7A
198.6BMP4, CTNNB1, FGFR2, WNT7A
20
Show member pathways
8.3BMP15, BMP4, BMP5, FGFR2, TGFB1
218.3BMP4, BMP5, KIT, SOX9, TGFB1
228.0BMP4, CTNNB1, FGFR2, NOTCH2, SOX9
23
Show member pathways
8.0BMP4, BMP5, CTNNB1, FGFR2, TGFB1, WNT7A
247.6BMP4, CTNNB1, FGFR2, KIT, TGFB1, WNT7A
25
Show member pathways
7.3BMP4, BMP5, CTNNB1, FGFR2, KIT, TGFB1
26
Show member pathways
7.3AMH, AMHR2, BMP15, BMP4, BMP5, FGFR2
27
Show member pathways
7.0BMP15, BMP4, BMP5, CTNNB1, FGFR2, KIT

GO Terms for genes affiliated with Persistent Mullerian Duct Syndrome

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Cellular components related to Persistent Mullerian Duct Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1membrane-bounded vesicleGO:003198810.4BMP4, BMP5
2Golgi lumenGO:000579610.0FURIN, TGFB1, WNT7A
3nuclear transcription factor complexGO:00447989.9CTNNB1, SOX9, SRY
4cell surfaceGO:00099867.7FGFR2, FURIN, KIT, NOTCH2, TGFB1, WNT7A
5extracellular regionGO:00055767.0AMH, BMP4, FGFR2, INSL3, MIR4321, NOTCH2
6extracellular spaceGO:00056157.0AMH, BMP15, BMP4, BMP5, FURIN, INSL3

Biological processes related to Persistent Mullerian Duct Syndrome according to GeneCards Suite gene sharing:

(show top 50)    (show all 100)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of ovarian follicle developmentGO:200035510.5AMH, MIR4321
2positive regulation of DNA-dependent DNA replicationGO:200010510.5BMP4, BMP5
3oviduct developmentGO:006006610.4CTNNB1, WNT7A
4central nervous system vasculogenesisGO:002200910.4CTNNB1, WNT7A
5regulation of cartilage developmentGO:006103510.3BMP4, TGFB1
6positive regulation of extracellular matrix assemblyGO:190120310.3SOX9, TGFB1
7Mullerian duct regressionGO:000188010.2AMH, AMHR2, MIR4321
8ureter smooth muscle cell differentiationGO:007219310.2BMP4, SOX9
9positive regulation of kidney developmentGO:009018410.2BMP4, SOX9
10positive regulation of branching involved in lung morphogenesisGO:006104710.2BMP4, CTNNB1
11positive regulation of epithelial cell differentiationGO:003085810.1CTNNB1, SOX9
12embryonic hindlimb morphogenesisGO:00351169.9BMP4, CTNNB1, WNT7A
13regulation of cell fate commitmentGO:00104539.9BMP4, FGFR2
14regulation of morphogenesis of a branching structureGO:00606889.9BMP4, FGFR2
15branching involved in prostate gland morphogenesisGO:00604429.9BMP4, FGFR2
16mesenchymal cell proliferation involved in lung developmentGO:00609169.8CTNNB1, FGFR2
17SMAD protein signal transductionGO:00603959.8BMP15, BMP4, BMP5, TGFB1
18positive regulation of male gonad developmentGO:20000209.7NR5A1, SOX9, SRY
19positive regulation of pathway-restricted SMAD protein phosphorylationGO:00108629.7BMP15, BMP4, BMP5, TGFB1
20regulation of cell differentiationGO:00455959.6BMP4, CTNNB1, SOX9
21negative regulation of chondrocyte differentiationGO:00323319.6BMP4, CTNNB1, SOX9
22negative regulation of myoblast differentiationGO:00456629.6BMP4, SOX9, TGFB1
23ovarian follicle developmentGO:00015419.6BMP15, BMP4, KIT
24epithelial tube branching involved in lung morphogenesisGO:00604419.6BMP4, CTNNB1, SOX9
25T cell differentiationGO:00302179.5CTNNB1, KIT, TGFB1
26branching involved in ureteric bud morphogenesisGO:00016589.5BMP4, CTNNB1, SOX9
27sex differentiationGO:00075489.4AMH, AMHR2, MIR4321, WNT7A
28chondrocyte differentiationGO:00020629.4BMP4, SOX9, TGFB1, WNT7A
29prostate gland morphogenesisGO:00605129.4BMP4, FGFR2, SOX9
30positive regulation of mesenchymal cell proliferationGO:00020539.3CTNNB1, FGFR2, SOX9
31cellular response to mechanical stimulusGO:00712609.3BMP4, CTNNB1, SOX9, TGFB1
32ureteric bud developmentGO:00016579.3BMP4, FGFR2, TGFB1
33embryonic cranial skeleton morphogenesisGO:00487019.2BMP4, CTNNB1, FGFR2
34digestive tract developmentGO:00485659.2FGFR2, KIT, TGFB1
35skeletal system developmentGO:00015019.2BMP4, BMP5, CTNNB1, SOX9
36negative regulation of gene expressionGO:00106299.2BMP4, CTNNB1, SOX9, TGFB1
37regulation of apoptotic processGO:00429819.1BMP15, BMP5, CTNNB1, SOX9, TGFB1
38cell fate commitmentGO:00451659.1BMP4, FGFR2, SOX9, WNT7A
39response to estradiolGO:00323559.1BMP4, CTNNB1, TGFB1, WNT7A
40epithelial to mesenchymal transitionGO:00018378.9CTNNB1, FGFR2, SOX9, TGFB1
41cell-cell signalingGO:00072678.8AMH, FGFR2, INSL3, MIR4321, NR5A1
42regulation of cell proliferationGO:00421278.7CTNNB1, KIT, SOX9, TGFB1, WNT7A
43negative regulation of epithelial cell proliferationGO:00506808.7BMP4, FGFR2, SOX9, TGFB1
44male gonad developmentGO:00085848.6AMHR2, INSL3, KIT, NR5A1, SOX9, SRY
45positive regulation of epithelial cell proliferationGO:00506798.4BMP4, BMP5, FGFR2, SOX9, TGFB1
46positive regulation of transcription, DNA-templatedGO:00458938.1BMP15, BMP4, CTNNB1, NR5A1, SOX9, SRY
47negative regulation of cell proliferationGO:00082857.9BMP4, BMP5, CTNNB1, INSL3, NOTCH2, SOX9
48positive regulation of transcription from RNA polymerase II promoterGO:00459447.2BMP4, BMP5, CTNNB1, FGFR2, NR5A1, SOX9
49positive regulation of gene expressionGO:00106287.0AMH, BMP4, CTNNB1, KIT, MIR4321, PLP1
50positive regulation of cell proliferationGO:00082846.5BMP4, CTNNB1, FGFR2, INSL3, KIT, SOX9

Molecular functions related to Persistent Mullerian Duct Syndrome according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1BMP receptor bindingGO:007070010.3BMP4, BMP5
2transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingGO:00037059.8NR5A1, SOX9, SRY
3hormone activityGO:00051799.8AMH, INSL3, MIR4321
4protease bindingGO:00020209.2FURIN, INSL3, KIT
5cytokine activityGO:00051258.9BMP15, BMP4, BMP5, TGFB1, WNT7A
6transforming growth factor beta receptor bindingGO:00051608.9AMH, BMP15, BMP4, BMP5, MIR4321, TGFB1
7growth factor activityGO:00080838.1AMH, BMP15, BMP4, BMP5, MIR4321, TGFB1

Sources for Persistent Mullerian Duct Syndrome

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet