MCID: PRS054
MIFTS: 27

Persistent Truncus Arteriosus malady

Summaries for Persistent Truncus Arteriosus

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Persistent truncus arteriosus (or Truncus arteriosus), also known as Common arterial trunk, is a rare... more...

MalaCards: Persistent Truncus Arteriosus is related to tricuspid atresia and cardiac tamponade. An important gene associated with Persistent Truncus Arteriosus is NKX2-6 (NK2 homeobox 6). Affiliated tissues include heart, and related mouse phenotypes are normal and respiratory system.

Description from OMIM:47 217095

Aliases & Classifications for Persistent Truncus Arteriosus

Sources:
43NIH Rare Diseases, 47OMIM
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Aliases & Descriptions:

persistent truncus arteriosus 43 47


Related Diseases for Persistent Truncus Arteriosus

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Persistent Truncus Arteriosus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1tricuspid atresia10.6
2cardiac tamponade10.3
3patent foramen ovale10.3
4polydactyly10.3
5orbital cyst10.3
6ventricular septal defect10.3
7aortic arch interruption10.3
8conotruncal heart malformations10.0NKX2-6, GATA6

Graphical network of diseases related to Persistent Truncus Arteriosus:



Diseases related to persistent truncus arteriosus

Clinical Features for Persistent Truncus Arteriosus

Sources:
47OMIM
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Clinical features from OMIM:

217095

Drugs & Therapeutics for Persistent Truncus Arteriosus

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Persistent Truncus Arteriosus

Drug clinical trials:

Search ClinicalTrials for Persistent Truncus Arteriosus

Search NIH Clinical Center for Persistent Truncus Arteriosus

Search CenterWatch for Persistent Truncus Arteriosus

Genetic Tests for Persistent Truncus Arteriosus

Anatomical Context for Persistent Truncus Arteriosus

Sources:
31LifeMap Discovery™, 33MalaCards
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MalaCards organs/tissues related to Persistent Truncus Arteriosus:

33
Heart

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Persistent Truncus Arteriosus:
id TissueAnatomical CompartmentCell Relevance
1 Neural CrestCardiac Neural CrestCardiac Neural Crest Cells Potential therapeutic candidate, affected by disease
2 Head MesenchymeBranchial Arch 3,4,6Cardiac Neural Crest Cells Potential therapeutic candidate, affected by disease
3 HeartOutflow TractNeural Crest Outflow Tract Cells Potential therapeutic candidate, affected by disease
4 HeartAorticopulmonary Septum  Affected by disease
5 HeartOutflow Tract Cushion  Affected by disease

Animal Models for Persistent Truncus Arteriosus or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Persistent Truncus Arteriosus:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028739.1NKX2-6, GATA6
2MP:00053889.0NKX2-6, GATA6
3MP:00053808.8NKX2-6, GATA6

Publications for Persistent Truncus Arteriosus

Sources:
51PubMed
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Articles related to Persistent Truncus Arteriosus:

(show top 50)    (show all 115)
idTitleAuthorsYear
1
Mid-term results after correction of type I and type II persistent truncus arteriosus in older patients. (22458281)
2012
2
Long-term follow-up of persistent truncus arteriosus: Kuwait experience. (22205122)
2012
3
A unique association with persistent truncus arteriosus and partial midline chest wall defect. (22608911)
2012
4
Staged biventricular repair for persistent truncus arteriosus with aortic arch obstruction following bilateral pulmonary artery banding. (21047826)
2011
5
Newborn with persistent truncus arteriosus and interrupted aortic arch demonstrating reverse left subclavian artery flow. (20957476)
2010
6
Long-term results after correction of persistent truncus arteriosus in 83 patients. (20137966)
2010
7
Persistent truncus arteriosus with intact ventricular septum diagnosed by echocardiography. (19951618)
2009
8
Cardiovascular flashlight. Persistent truncus arteriosus: a rare finding in adults. (19224931)
2009
9
Ante-mortem diagnosis of persistent truncus arteriosus in an 8-year-old asymptomatic dog. (19446515)
2009
10
Persistent truncus arteriosus with double aortic arch. (16565901)
2006
11
Repair of persistent truncus arteriosus with interrupted aortic arch: what did we learn? (16476547)
2006
12
Persistent truncus arteriosus in a 6-year-old cat. (16109102)
2005
13
Repair of persistent truncus arteriosus with interrupted aortic arch. (16194613)
2005
14
Persistent truncus arteriosus: twenty years experience in a tertiary care center in Taiwan. (16302570)
2005
15
Persistent truncus arteriosus in a rhesus monkey (Macaca mulatta). (12102574)
2002
16
Persistent truncus arteriosus in monozygotic twins: case report and literature review. (9934979)
1999
17
Factors associated with outcomes of persistent truncus arteriosus. (10440171)
1999
18
Tricuspid atresia with persistent truncus arteriosus. (10389376)
1999
19
Successful reoperation for severe left bronchus compression after repair of persistent truncus arteriosus with interrupted aortic arch. (9628382)
1998
20
Excitation-contraction coupling in the day 15 embryonic chick heart with persistent truncus arteriosus. (9396550)
1997
21
Persistent truncus arteriosus associated with interrupted aortic arch: report of two cases. (8368068)
1993
22
Pathogenesis of persistent truncus arteriosus induced by nimustine hydrochloride in chick embryos. (2727936)
1989
23
Echocardiographic--angiocardiographic correlation in persistent truncus arteriosus. (2807455)
1989
24
Pathogenesis of persistent truncus arteriosus and dextroposed aorta in the chick embryo after neural crest ablation. (3791607)
1987
25
Fatal infective endocarditis in a young adult with persistent truncus arteriosus and a bicuspid truncal valve. (3751940)
1986
26
Persistent truncus arteriosus: pathologic anatomy in 54 cases. (3797293)
1986
27
Two-dimensional echocardiographic evaluation of persistent truncus arteriosus. (7148716)
1982
28
Surgical experience with persistent truncus arteriosus in symptomatic infants under 1 year of age. Report of 13 consecutive cases. (7272128)
1981
29
Two-dimensional echocardiography in infants with persistent truncus arteriosus. (7317216)
1981
30
Persistent truncus arteriosus communis in a two-year-old steer. (532058)
1979
31
Pathogenesis of persistent truncus arteriosus in light of observations made in a dog embryo with the anomaly. (645581)
1978
32
Stenotic semilunar valve in persistent truncus arteriosus. (1248273)
1976
33
Editorial: persistent truncus arteriosus: a comment. (961567)
1976
34
Persistent truncus arteriosus associated with tricuspid atresia. (4846062)
1974
35
Banding of the pulmonary trunk in persistent truncus arteriosus. Rapid subsequent development of inadequate pulmonary blood flow. (4746353)
1973
36
Correction of persistent truncus arteriosus. (5101261)
1971
37
Malposition of pulmonary arteries (crossed pulmonary arteries) in persistent truncus arteriosus. (5489689)
1970
38
Persistent truncus arteriosus. A radiographic and angiocardiographic study. (4243525)
1969
39
Persistent truncus arteriosus in infancy. A study of 14 cases. (5782843)
1969
40
Phonocardiographic findings in persistent truncus arteriosus. (5718989)
1968
41
Persistent truncus arteriosus in a cat. (5691152)
1968
42
Angiocardiographic differentiation between Fallot's pulmonary atresia and type IV persistent truncus arteriosus. (6025200)
1967
43
PERSISTENT TRUNCUS ARTERIOSUS. AN UNUSUAL VARIANT WITH ATRESIA OF THE AORTIC ARCH. (14218863)
1965
44
Persistent truncus arteriosus with absence of the pulmonary artery system. (5858503)
1965
45
PULMONARY ARTERY BANDING FOR PERSISTENT TRUNCUS ARTERIOSUS. REPORT OF A CASE. (14144752)
1964
46
Persistent truncus arteriosus; a classification according to anatomic types. (18141293)
1949
47
Cardiac malformation; report of a case of persistent truncus arteriosus. (18106312)
1948
48
Persistent truncus arteriosus, a rare congenital cardiac malformation. (18901524)
1948
49
PERSISTENT TRUNCUS ARTERIOSUS. (18609943)
1943
50
Persistent truncus arteriosus communis with microphthalmos, orbital cyst and polydactyly. (21032055)
1937

Genetic Variations for Persistent Truncus Arteriosus

Expression for genes affiliated with Persistent Truncus Arteriosus

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Persistent Truncus Arteriosus

Search GEO for disease gene expression data for Persistent Truncus Arteriosus.

Pathways for genes affiliated with Persistent Truncus Arteriosus

Compounds for genes affiliated with Persistent Truncus Arteriosus

GO Terms for genes affiliated with Persistent Truncus Arteriosus

Sources:
16Gene Ontology
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Biological processes related to Persistent Truncus Arteriosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of apoptotic processGO:0430669.1NKX2-6, GATA6

Molecular functions related to Persistent Truncus Arteriosus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA binding transcription factor activityGO:0037009.1NKX2-6, GATA6

Products for genes affiliated with Persistent Truncus Arteriosus

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  • Proteins
  • Lysates
  • Antibodies

Sources for Persistent Truncus Arteriosus

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet