Aliases & Classifications for Persistent Vegetative State

MalaCards integrated aliases for Persistent Vegetative State:

Name: Persistent Vegetative State 50 51 69

External Ids:

UMLS 69 C0242670

Summaries for Persistent Vegetative State

NINDS : 50 A coma, sometimes also called persistent vegetative state, is a profound or deep state of unconsciousness. Persistent vegetative state is not brain-death. An individual in a state of coma is alive but unable to move or respond to his or her environment. Coma may occur as a complication of an underlying illness, or as a result of injuries, such as head trauma. . Individuals in such a state have lost their thinking abilities and awareness of their surroundings, but retain non-cognitive function and normal sleep patterns. Even though those in a persistent vegetative state lose their higher brain functions, other key functions such as breathing and circulation remain relatively intact. Spontaneous movements may occur, and the eyes may open in response to external stimuli. Individuals may even occasionally grimace, cry, or laugh. Although individuals in a persistent vegetative state may appear somewhat normal, they do not speak and they are unable to respond to commands.

MalaCards based summary : Persistent Vegetative State is related to traumatic brain injury and brain injury, and has symptoms including other alteration of consciousness, transient alteration of awareness and syncope. An important gene associated with Persistent Vegetative State is SLC25A22 (Solute Carrier Family 25 Member 22), and among its related pathways/superpathways are Glucose / Energy Metabolism and Neuroscience. The drugs Midazolam and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and heart, and related phenotype is taste/olfaction.

Wikipedia : 72 A persistent vegetative state (PVS) is a disorder of consciousness in which patients with severe brain... more...

Related Diseases for Persistent Vegetative State

Diseases related to Persistent Vegetative State via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)
# Related Disease Score Top Affiliating Genes
1 traumatic brain injury 29.9 APOE ENO2
2 brain injury 29.8 APOE ENO2
3 head injury 29.7 APOE ENO2
4 ocular motor apraxia 11.3
5 panencephalitis, subacute sclerosing 11.2
6 epileptic encephalopathy, early infantile, 3 11.2
7 cerebritis 10.2
8 dementia 10.0
9 episodic pain syndrome, familial, 1 10.0
10 blood group--diego system 9.9
11 vascular dementia 9.9
12 hypoglycemia 9.9
13 creutzfeldt-jakob disease 9.7 APOE ENO2
14 sleep disorder 9.7
15 dystonia 9.7
16 alzheimer disease 9.7
17 neuronitis 9.7
18 multiple sclerosis 9.7
19 encephalitis 9.7
20 anencephaly 9.7
21 anoxia 9.7
22 locked-in syndrome 9.7
23 ischemia 9.7
24 hydrocephalus 9.7 APOE ENO2
25 stroke, ischemic 9.5 APOE ENO2

Comorbidity relations with Persistent Vegetative State via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Heart Disease

Graphical network of the top 20 diseases related to Persistent Vegetative State:



Diseases related to Persistent Vegetative State

Symptoms & Phenotypes for Persistent Vegetative State

UMLS symptoms related to Persistent Vegetative State:


other alteration of consciousness, transient alteration of awareness, syncope

MGI Mouse Phenotypes related to Persistent Vegetative State:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 taste/olfaction MP:0005394 8.62 APOE ENO2

Drugs & Therapeutics for Persistent Vegetative State

Drugs for Persistent Vegetative State (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
2
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 5311068 56032 68602
3
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
4 Analgesics Phase 4
5 Neurotransmitter Agents Phase 4,Phase 2
6 Analgesics, Non-Narcotic Phase 4
7 Peripheral Nervous System Agents Phase 4,Phase 2
8 Central Nervous System Depressants Phase 4
9 Adjuvants, Anesthesia Phase 4
10 Adrenergic Agents Phase 4
11 Adrenergic Agonists Phase 4
12 Adrenergic alpha-2 Receptor Agonists Phase 4
13 Adrenergic alpha-Agonists Phase 4
14 GABA Agents Phase 4
15 GABA Modulators Phase 4
16 Tranquilizing Agents Phase 4
17 Anesthetics Phase 4
18 Anesthetics, General Phase 4
19 Anesthetics, Intravenous Phase 4
20 Anti-Anxiety Agents Phase 4
21 Hypnotics and Sedatives Phase 4
22 Psychotropic Drugs Phase 4
23
Dopamine Approved Phase 2 51-61-6, 62-31-7 681
24
Apomorphine Approved, Investigational Phase 2 58-00-4, 41372-20-7 6005
25 Dopamine Agents Phase 2
26 Dopamine agonists Phase 2
27 Gastrointestinal Agents Phase 2
28 Emetics Phase 2
29 Pharmaceutical Solutions Phase 2,Phase 1
30 Autonomic Agents Phase 2
31
Amantadine Approved 768-94-5 2130
32
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
33 tannic acid Approved, Nutraceutical
34 Anti-Infective Agents
35 Antiparkinson Agents
36 Antiviral Agents
37 Fluorodeoxyglucose F18 Early Phase 1
38 Radiopharmaceuticals Early Phase 1

Interventional clinical trials:

(show all 29)

# Name Status NCT ID Phase Drugs
1 Is Sensory Stimulation Effective in Reducing Time Spent in a Coma or Vegetative State Unknown status NCT00163878 Phase 4
2 Dexmedetomidine vs Midazolam for Intraoperative Sedation Completed NCT02878837 Phase 4 Dexmedetomidine;Midazolam
3 Vagus Nerve Stimulation to Augment Recovery From Minimally Conscious or Persistently Vegetative States After Traumatic Brain Injury Unknown status NCT01260090 Phase 3
4 Two Intensities of Transcranial Direct Current Stimulation to Improve Consciousness in Severely Brain Injured Patients Recruiting NCT03007784 Phase 3
5 Thalamic Stimulation of Patients in Vegetative or Minimally Conscious State Unknown status NCT01027572 Phase 2
6 tDCS on Precuneus in MCS: Repeated Stimulations Completed NCT02702362 Phase 2
7 Transcranial Direct Current Stimulation in Patients With Disorders of Consciousness Completed NCT01673126 Phase 2
8 The Efficacy of Familiar Voice Stimulation During Coma Recovery Completed NCT00557076 Phase 1, Phase 2
9 Efficacy Study of NH001 in Vegetative State & Minimally Conscious State Following a Traumatic Brain Injury Suspended NCT00761228 Phase 2 Apomorphine;Placebo
10 The Impact of RPh201 on CVS Patients: Clinical and fMRI Measurements Withdrawn NCT01417299 Phase 1, Phase 2
11 The Impact of RPh201 on Chronic Vegetative State (CVS): fMRI Study Suspended NCT01438684 Phase 1 RPh201;Saline
12 Amantadine and Functional Improvement Following ABI Measured by MRI Tractography; A Pilot Study Unknown status NCT02566720 Amantadine
13 Effectiveness of Sensory Stimulation for Person in a Coma or Persistent Vegetative State After Traumatic Brain Injury Completed NCT02629588
14 A Study to Tailor Advance Directives Completed NCT00121004
15 Further Psychometric Data for the Reliability and the Diagnostic Validity of CRS-R Completed NCT03126929
16 Personalized Objects Can Improve the Diagnosis of EMCS From MCS Completed NCT02988206
17 Pupil Near Response in UWS Patients Completed NCT02832492
18 Transcranial Brain Stimulation in Vegetative State Patients Completed NCT01820923
19 Transcranial Direct Current Stimulation Effects in Patients With Chronic Consciousness Disorders Completed NCT02288533
20 Analysis of Vital, Facial and Muscular Responses Front to Music or Message in Coma, Vegetative State or Sedated Patients Completed NCT01141790
21 Navigated Brain Stimulation in Diagnosis of Minimally Conscious State Completed NCT01467908
22 Fronto-parietal tDCS in Severely Brain Injured Patients With Disorders of Consciousness Completed NCT02626403
23 tDCS in MCS: Repeated Stimulations Completed NCT02019615
24 Study of Conscious Behavior Under Low-frequency Deep Brain Stimulation in Chronic and Severe Post-coma Disorders of Consciousness Completed NCT01718249
25 18F-FDG PET/CT in Diagnostic Patients of Disorder of Consciousness Recruiting NCT02999490 Early Phase 1
26 Resuscitation Registry - Surrogate Markers of Outcome After Cardiac Arrest Recruiting NCT02722460
27 Effects of Whole-body Vibration Exercise in Brain Injury Patients With Minimally Conscious State Recruiting NCT03389113
28 Vagal Nerve Stimulation in Coma Patients Recruiting NCT02591069
29 tDCS in Patients With Disorder of Consciousness Due to Severe Acquired Brain Injury Not yet recruiting NCT03367078

Search NIH Clinical Center for Persistent Vegetative State

Genetic Tests for Persistent Vegetative State

Anatomical Context for Persistent Vegetative State

MalaCards organs/tissues related to Persistent Vegetative State:

38
Brain, Eye, Heart, Pituitary, Thalamus, Spinal Cord, Bone

Publications for Persistent Vegetative State

Articles related to Persistent Vegetative State:

(show top 50) (show all 319)
# Title Authors Year
1
Effects of percutaneous endoscopic gastrostomy on survival of patients in a persistent vegetative state after stroke. ( 27878869 )
2017
2
Prevalence of persistent vegetative state in patients with severe traumatic brain injury and its trend during the past four decades: A meta-analysis. ( 27814303 )
2017
3
Treatment of a Pregnant Patient in a Persistent Vegetative State. ( 27926646 )
2017
4
Recovery from Chronic Diseases of Consciousness: State of the Art in Neuromodulation for Persistent Vegetative State and Minimally Conscious State. ( 28120048 )
2017
5
Evaluation of nursing interventions using minimally invasive assessments methods for patients in a persistent vegetative state. ( 28378507 )
2017
6
Awakening with amantadine from a persistent vegetative state after subarachnoid haemorrhage. ( 28739616 )
2017
7
Persistent vegetative state and minimally conscious state: ethical, legal and practical dilemmas. ( 28663409 )
2017
8
Xingnao Kaiqiao acupuncture combined with Angong Niuhuang Wan for a patient under persistent vegetative state: a case report. ( 28791670 )
2017
9
Effectiveness of Sensory Stimulation to Improve Arousal and Alertness of People in a Coma or Persistent Vegetative State After Traumatic Brain Injury: A Systematic Review. ( 27089287 )
2016
10
Ascending Reticular Activating System in a Patient with Persistent Vegetative State. ( 26745220 )
2016
11
Open traumatic brain injury by nail gun resulting in a persistent vegetative state. ( 27044613 )
2016
12
Intraventricular Transplantation of Autologous Bone Marrow Mesenchymal Stem Cells via Ommaya Reservoir in Persistent Vegetative State Patients after Haemorrhagic Stroke: Report of Two Cases & Review of the Literature. ( 28096634 )
2016
13
Magnetic resonance imaging characteristics of persistent vegetative state due to prolonged hypoglycemia. ( 25738058 )
2015
14
Persistent vegetative state and minimally conscious state. ( 25891806 )
2015
15
Should patients in a persistent vegetative state be allowed to die? Guidelines for a new standard of care in Australian hospitals. ( 26507136 )
2015
16
Brainstem neurons survive the identical ischemic stress that kills higher neurons: insight to the persistent vegetative state. ( 24802253 )
2014
17
Zolpidem Arousing Effect In Persistent Vegetative State Patients: Autonomic, Eeg And Behavioral Assessment. ( 24025063 )
2013
18
From hope to despair, and back: being the wife of a patient in a persistent vegetative state. ( 23188382 )
2013
19
Causes and outcomes of persistent vegetative state in a Chinese versus American referral hospital. ( 23099847 )
2013
20
Ethics and Health Policy of Dialyzing a Patient in a Persistent Vegetative State. ( 24115197 )
2013
21
Focal increase in cerebral blood flow after treatment with near-infrared light to the forehead in a patient in a persistent vegetative state. ( 22047598 )
2012
22
A Cuban perspective on management of persistent vegetative state. ( 22334112 )
2012
23
Court case adjourned after diagnosis of persistent vegetative state changes. ( 22930714 )
2012
24
Persistent vegetative state: an ethical reappraisal. ( 22131038 )
2012
25
Responsiveness of a patient in a persistent vegetative state after a coma to weekly injections of autologous activated immune cells: a case report. ( 22234176 )
2012
26
Characteristics of infradian and circadian rhythms in the persistent vegetative state. ( 22289544 )
2011
27
A long-term intensive behavioral treatment study in patients with persistent vegetative state or minimally conscious state. ( 21305239 )
2011
28
Measuring interconnection of the residual cortical functional islands in persistent vegetative state and minimal conscious state with EEG nonlinear analysis. ( 21530389 )
2011
29
More dead than dead: perceptions of persons in the persistent vegetative state. ( 21798528 )
2011
30
The place of L-dopa/carbidopa in persistent vegetative state. ( 21060281 )
2010
31
Persistent vegetative state. ( 20132712 )
2010
32
In the name of good intentions: nurses' perspectives on caring for a pregnant patient in a persistent vegetative state. ( 20124019 )
2010
33
Zolpidem for persistent vegetative state--a placebo-controlled trial in pediatrics. ( 21210338 )
2010
34
Covert cognition in the persistent vegetative state. ( 20138110 )
2010
35
Are people in a persistent vegetative state conscious? ( 20069822 )
2009
36
Dorsal column stimulation in persistent vegetative state. ( 22151220 )
2009
37
Intrathecal baclofen in patients with persistent vegetative state: 2 hypotheses. ( 19577040 )
2009
38
Cortical sources of resting-state alpha rhythms are abnormal in persistent vegetative state patients. ( 19299197 )
2009
39
Media coverage of the persistent vegetative state and end-of-life decision-making: Theresa Schiavo's tragedy and ours, too. ( 19752461 )
2009
40
Heart rate non linear dynamics in patients with persistent vegetative state: a preliminary report. ( 18183507 )
2008
41
A MRS-MRI-fMRI exploration of the brain. Impact of long-lasting persistent vegetative state. ( 18240041 )
2008
42
Media coverage of the persistent vegetative state and end-of-life decision-making. ( 18685135 )
2008
43
Prevention of venous thromboembolism and persistent vegetative state: A medical and an ethical issue. ( 18549951 )
2008
44
Persistent vegetative state in electrical injuries: a 10-year review. ( 17913369 )
2008
45
Recognizing a mother's voice in the persistent vegetative state. ( 17844939 )
2007
46
The experiences of pediatric nurses caring for children in a persistent vegetative state. ( 17693906 )
2007
47
Intrathecal baclofen in the treatment of post-stroke central pain, dystonia, and persistent vegetative state. ( 17691381 )
2007
48
Dorsal column stimulation for persistent vegetative state. ( 17691409 )
2007
49
Persistent vegetative state and dementia in the elderly. ( 17234039 )
2007
50
Does any aspect of mind survive brain damage that typically leads to a persistent vegetative state? Ethical considerations. ( 18086316 )
2007

Variations for Persistent Vegetative State

Expression for Persistent Vegetative State

Search GEO for disease gene expression data for Persistent Vegetative State.

Pathways for Persistent Vegetative State

Pathways related to Persistent Vegetative State according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.44 APOE ENO2
2 11.33 APOE ENO2 GABBR1

GO Terms for Persistent Vegetative State

Sources for Persistent Vegetative State

3 CDC
7 CNVD
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10 dbSNP
11 DGIdb
16 ExPASy
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32 ICD10
33 ICD10 via Orphanet
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65 SNOMED-CT via HPO
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67 TGDB
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70 UMLS via Orphanet
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