MCID: PRS064
MIFTS: 34

Persistent Vegetative State malady

Summaries for Persistent Vegetative State

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Sources:
45NINDS, 66Wikipedia, 34MalaCards
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NINDS:45 A coma, sometimes also called persistent vegetative state, is a profound or deep state of unconsciousness. Persistent vegetative state is not brain-death. An individual in a state of coma is alive but unable to move or respond to his or her environment. Coma may occur as a complication of an underlying illness, or as a result of injuries, such as head trauma. . Individuals in such a state have lost their thinking abilities and awareness of their surroundings, but retain non-cognitive function and normal sleep patterns. Even though those in a persistent vegetative state lose their higher brain functions, other key functions such as breathing and circulation remain relatively intact. Spontaneous movements may occur, and the eyes may open in response to external stimuli. Individuals may even occasionally grimace, cry, or laugh. Although individuals in a persistent vegetative state may appear somewhat normal, they do not speak and they are unable to respond to commands.

MalaCards: Persistent Vegetative State is related to multiple sclerosis and cerebritis. An important gene associated with Persistent Vegetative State is GABBR1 (gamma-aminobutyric acid (GABA) B receptor, 1), and among its related pathways are Glucose / Energy Metabolism and Neuroscience. The compounds taurine and bicarbonate have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and heart, and related mouse phenotypes are taste/olfaction and nervous system.

Wikipedia:66 A persistent vegetative state is a disorder of consciousness in which patients with severe brain damage... more...

Aliases & Classifications for Persistent Vegetative State

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Sources:
45NINDS, 46Novoseek, 63UMLS
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Aliases & Descriptions:

persistent vegetative state 45 46 63


Related Diseases for Persistent Vegetative State

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18GeneCards, 19GeneDecks
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Diseases related to Persistent Vegetative State via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 23)
idRelated DiseaseScoreTop Affiliating Genes
1multiple sclerosis30.4APOE
2cerebritis10.6
3dementia10.5
4oculomotor apraxia cogan type10.5
5brain injury10.4
6head injury10.4
7traumatic brain injury10.4
8vascular dementia10.3
9subacute sclerosing panencephalitis10.2
10hypoglycemia10.2
11locked-in syndrome10.2
12dystonia10.2
13ischemia10.2
14sleep disorder10.2
15anencephaly10.2
16epileptic encephalopathy, early infantile, 310.2
17anoxia10.2
18dawson disease10.2
19thromboembolism10.2
20venous thromboembolism10.2
21hemorrhage, intracerebral10.0ENO2, APOE
22creutzfeldt-jakob disease10.0ENO2, APOE
23cerebrovascular disease10.0APOE, ENO2

Graphical network of the top 20 diseases related to Persistent Vegetative State:



Diseases related to persistent vegetative state

Symptoms for Persistent Vegetative State

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Drugs & Therapeutics for Persistent Vegetative State

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Persistent Vegetative State

Drug clinical trials:

Search ClinicalTrials for Persistent Vegetative State

Search NIH Clinical Center for Persistent Vegetative State

Search CenterWatch for Persistent Vegetative State

Genetic Tests for Persistent Vegetative State

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Anatomical Context for Persistent Vegetative State

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34MalaCards
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MalaCards organs/tissues related to Persistent Vegetative State:

34
Brain, Eye, Heart, Spinal cord, Thalamus, Pituitary

Animal Models for Persistent Vegetative State or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Persistent Vegetative State:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.0ENO2, APOE
2MP:00036318.5ENO2, GABBR1, APOE
3MP:00053868.2ENO2, GABBR1, APOE

Publications for Persistent Vegetative State

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53PubMed
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Articles related to Persistent Vegetative State:

(show top 50)    (show all 301)
idTitleAuthorsYear
1
Ethics and Health Policy of Dialyzing a Patient in a Persistent Vegetative State. (24115197)
2013
2
Causes and outcomes of persistent vegetative state in a Chinese versus American referral hospital. (23099847)
2013
3
A long-term intensive behavioral treatment study in patients with persistent vegetative state or minimally conscious state. (21305239)
2011
4
The place of L-dopa/carbidopa in persistent vegetative state. (21060281)
2010
5
Cortical sources of resting-state alpha rhythms are abnormal in persistent vegetative state patients. (19299197)
2009
6
Recognizing a mother's voice in the persistent vegetative state. (17844939)
2007
7
Persistent vegetative state and dementia in the elderly. (17234039)
2007
8
Persistent vegetative state. (17485655)
2007
9
Tube feedings and persistent vegetative state patients: ordinary or extraordinary means? (16830413)
2006
10
Successful neonatal outcome in 2 cases of maternal persistent vegetative state treated in a labor and delivery suite. (16631100)
2006
11
Advance directives and the persistent vegetative state in Victoria: a human rights perspective. (16304765)
2005
12
Withdrawing life-sustaining treatment in patients with persistent vegetative state and without an advance directive. (15625919)
2004
13
Ethics roundtable debate: withdrawal of tube feeding in a patient with persistent vegetative state where the patients wishes are unclear and there is family dissension. (15025760)
2004
14
Successful management of multiple sclerosis and persistent vegetative state requires frequent reassessment. (12857365)
2003
15
Postmodernism and the persistent vegetative state. (12854583)
2002
16
Detecting residual cognitive function in persistent vegetative state. (12499414)
2002
17
Withdrawing nutrition and hydration. The Catholic tradition offers guidance for the treatment of patients in a persistent vegetative state. (11763577)
2001
18
Japanese physicians and the care of adult patients in persistent vegetative state. (10786328)
2000
19
CPR for patients in a persistent vegetative state? (9679478)
1998
20
Persistent vegetative state. (9817437)
1998
21
Persistent vegetative state. (9439524)
1998
22
Cortical processing in persistent vegetative state. (9798618)
1998
23
Persistent vegetative state. (9357427)
1997
24
Euthanasia and persistent vegetative state individuals: the role and moral status of autonomy. (15156859)
1996
25
Euthanasia, physician-assisted suicide, and persistent vegetative state. (8757170)
1996
26
Survey of British clinicians' views on management of patients in persistent vegetative state. (8691931)
1996
27
Euthanasia, physician assisted suicide, and persistent vegetative state. (8786683)
1996
28
Persistent vegetative state: important considerations for the neuroscience nurse. (8818986)
1996
29
Euthanasia, physician-assisted suicide, and persistent vegetative state. (8786682)
1996
30
The unmodulated oculocephalic reflex: clinical feature of the persistent vegetative state in the neonate. (8734036)
1996
31
Euthanasia, physician-assisted suicide, and persistent vegetative state. (8757171)
1996
32
The lived experience of registered nurses involved in the withdrawal of nutrition and hydration in a persistent vegetative state (PVS) patient. (7626948)
1995
33
The persistent vegetative state. (7866201)
1995
34
Medical aspects of the persistent vegetative state--a correction. The Multi-Society Task Force on PVS. (7777031)
1995
35
Practice parameters: assessment and management of patients in the persistent vegetative state (summary statement). The Quality Standards Subcommittee of the American Academy of Neurology. (7746375)
1995
36
The persistent vegetative state. (7976218)
1994
37
Withdrawing treatment in the persistent vegetative state. (7935719)
1994
38
Document on the persistent vegetative state by the SocietA Italiana di Neurologia (SIN) Working Group on Bioethics and Neurology. (8125768)
1993
39
Persistent vegetative state and withdrawal of nutrition and hydration. (8331639)
1993
40
Managing patients in a persistent vegetative state. (8401143)
1993
41
Recovery of patients after four months or more in the persistent vegetative state. (8329926)
1993
42
HM-PAO-SPECT in persistent vegetative state after head injury: prognostic indicator of the likelihood of recovery? (2071761)
1991
43
Characterization and modification of brain activity with deep brain stimulation in patients in a persistent vegetative state: pain-related late positive component of cerebral evoked potential. (1705325)
1991
44
The biology of the persistent vegetative state: legal, ethical, and philosophical implications for transplantation. (2349730)
1990
45
Editor's introduction: family privacy and persistent vegetative state. (2628643)
1989
46
Recovery from persistent vegetative state? The case of Carrie Coons. (2501234)
1989
47
Position of the American Academy of Neurology on certain aspects of the care and management of the persistent vegetative state patient. Adopted by the Executive Board, American Academy of Neurology, April 21, 1988, Cincinnati, Ohio. (2909900)
1989
48
A persistent vegetative state. (11653625)
1984
49
Traumatic coma during pregnancy with persistent vegetative state. Case report. (6433967)
1984
50
Termination of treatment in the persistent vegetative state. (11649666)
1984

Variations for Persistent Vegetative State

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Expression for genes affiliated with Persistent Vegetative State

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Persistent Vegetative State

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Pathways for genes affiliated with Persistent Vegetative State

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51PathCards, 5Cell Signaling Technology
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Pathways related to Persistent Vegetative State according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1ENO2, APOE
28.5ENO2, GABBR1, APOE

Compounds for genes affiliated with Persistent Vegetative State

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46Novoseek, 62Tocris Bioscience, 25HMDB, 12DrugBank, 30IUPHAR, 52PharmGKB
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Compounds related to Persistent Vegetative State according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1taurine46 62 2511.7GABBR1, ENO2
2bicarbonate469.7ENO2, GABBR1
3catecholamine469.6ENO2, GABBR1
45-hydroxytryptamine469.6ENO2, GABBR1
5chloride469.6GABBR1, ENO2
6gaba469.6ENO2, GABBR1
7norepinephrine46 25 1211.5GABBR1, ENO2
8edss469.5ENO2, APOE
9potassium46 25 1211.5ENO2, GABBR1
10spec-t469.5ENO2, APOE
11tetrodotoxin46 62 3011.5APOE, ENO2
12ibmx46 62 3011.4APOE, ENO2
13hyaluronic acid46 2510.4ENO2, APOE
14forskolin46 52 1211.4ENO2, GABBR1
15guanine46 25 1211.4APOE, ENO2
16kainate46 3010.3GABBR1, APOE
17indomethacin46 30 62 1212.3ENO2, APOE
18adenylate469.3ENO2, GABBR1
19paraffin469.2ENO2, APOE
20glutamine469.1APOE, ENO2
21creatinine469.0ENO2, APOE
22nmda46 309.9ENO2, GABBR1, APOE
23acetylcholine46 52 30 25 1212.9APOE, GABBR1, ENO2
24dopamine46 30 25 1211.9ENO2, GABBR1, APOE
25aspartate468.9ENO2, GABBR1, APOE
26glutamate468.8ENO2, GABBR1, APOE
27heparin46 30 25 1211.8ENO2, APOE

GO Terms for genes affiliated with Persistent Vegetative State

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17Gene Ontology
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Cellular components related to Persistent Vegetative State according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendriteGO:0304259.0GABBR1, APOE

Products for genes affiliated with Persistent Vegetative State

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Sources for Persistent Vegetative State

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet