MCID: PRS064
MIFTS: 20

Persistent Vegetative State malady

Summaries for Persistent Vegetative State

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43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 A coma, sometimes also called persistent vegetative state, is a profound or deep state of unconsciousness. Persistent vegetative state is not brain-death. An individual in a state of coma is alive but unable to move or respond to his or her environment. Coma may occur as a complication of an underlying illness, or as a result of injuries, such as head trauma. . Individuals in such a state have lost their thinking abilities and awareness of their surroundings, but retain non-cognitive function and normal sleep patterns. Even though those in a persistent vegetative state lose their higher brain functions, other key functions such as breathing and circulation remain relatively intact. Spontaneous movements may occur, and the eyes may open in response to external stimuli. Individuals may even occasionally grimace, cry, or laugh. Although individuals in a persistent vegetative state may appear somewhat normal, they do not speak and they are unable to respond to commands.

MalaCards: Persistent Vegetative State is related to multiple sclerosis and ischemia. An important gene associated with Persistent Vegetative State is SLC25A22 (solute carrier family 25 (mitochondrial carrier: glutamate), member 22), and among its related pathways are Glucose / Energy Metabolism and Neuroscience. The compounds taurine and bicarbonate have been mentioned in the context of this disorder. Affiliated tissues include brain and eye, and related mouse phenotype taste/olfaction.

Wikipedia:63 A persistent vegetative state is a disorder of consciousness in which patients with severe brain damage... more...

Aliases & Classifications for Persistent Vegetative State

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43NINDS, 44Novoseek, 60UMLS
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Aliases & Descriptions:

persistent vegetative state 43 44 60


Related Diseases for Persistent Vegetative State

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17GeneCards, 18GeneDecks
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Diseases related to Persistent Vegetative State via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 19)
idRelated DiseaseScoreTop Affiliating Genes
1multiple sclerosis30.2APOE
2ischemia30.2GABBR1
3cerebritis10.6
4dementia10.5
5oculomotor apraxia cogan type10.5
6vascular dementia10.3
7subacute sclerosing panencephalitis10.2
8hypoglycemia10.2
9locked-in syndrome10.2
10encephalitis10.2
11sleep disorder10.2
12epileptic encephalopathy, early infantile, 310.2
13dawson disease10.2
14down syndrome10.0APOE
15status epilepticus10.0ENO2
16cerebrovascular disease10.0APOE
17stroke, ischemic10.0APOE
18hemorrhage, intracerebral10.0ENO2, APOE
19creutzfeldt-jakob syndrome10.0ENO2, APOE

Graphical network of diseases related to Persistent Vegetative State:



Diseases related to persistent vegetative state

Clinical Features for Persistent Vegetative State

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Drugs & Therapeutics for Persistent Vegetative State

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Persistent Vegetative State

Search CenterWatch for Persistent Vegetative State

Genetic Tests for Persistent Vegetative State

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Anatomical Context for Persistent Vegetative State

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32MalaCards
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MalaCards organs/tissues related to Persistent Vegetative State:

32
Brain, Eye

Animal Models for Persistent Vegetative State or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Persistent Vegetative State:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.1ENO2, APOE

Publications for Persistent Vegetative State

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Genetic Variations for Persistent Vegetative State

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Expression for genes affiliated with Persistent Vegetative State

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Persistent Vegetative State

Search GEO for disease gene expression data for Persistent Vegetative State.

Pathways for genes affiliated with Persistent Vegetative State

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4Cell Signaling Technology
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Pathways related to Persistent Vegetative State according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1ENO2, APOE
28.5ENO2, GABBR1, APOE

Compounds for genes affiliated with Persistent Vegetative State

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Sources:
44Novoseek, 59Tocris Bioscience, 24HMDB, 28IUPHAR, 11DrugBank, 49PharmGKB
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Compounds related to Persistent Vegetative State according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1taurine44 59 2411.6ENO2, GABBR1
2bicarbonate449.5ENO2, GABBR1
3catecholamine449.5GABBR1, ENO2
4edss449.4APOE, ENO2
5spec-t449.4APOE, ENO2
6tetrodotoxin44 59 2811.4ENO2, APOE
75-hydroxytryptamine449.3GABBR1, ENO2
8chloride449.3ENO2, GABBR1
9ibmx44 28 5911.2APOE, ENO2
10kainate44 2810.2GABBR1, APOE
11hyaluronic acid44 2410.0ENO2, APOE
12guanine44 11 2410.8ENO2, APOE
13nmda44 289.8ENO2, GABBR1, APOE
14acetylcholine44 49 28 11 2412.8APOE, GABBR1, ENO2
15dopamine44 28 11 2411.8ENO2, GABBR1, APOE
16aspartate448.7ENO2, GABBR1, APOE
17glutamate448.6GABBR1, ENO2, APOE

GO Terms for genes affiliated with Persistent Vegetative State

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16Gene Ontology
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Cellular components related to Persistent Vegetative State according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendriteGO:0304259.0GABBR1, APOE

Products for genes affiliated with Persistent Vegetative State

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Persistent Vegetative State

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet