MCID: PRS064
MIFTS: 24

Persistent Vegetative State malady

Aliases & Classifications for Persistent Vegetative State

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Sources:
46NINDS, 47Novoseek, 65UMLS
See all MalaCards sources

Aliases & Descriptions for Persistent Vegetative State:

Name: Persistent Vegetative State 46 47 65

External Ids:

UMLS65 C0242670

Summaries for Persistent Vegetative State

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NINDS:46 A coma, sometimes also called persistent vegetative state, is a profound or deep state of unconsciousness. Persistent vegetative state is not brain-death. An individual in a state of coma is alive but unable to move or respond to his or her environment. Coma may occur as a complication of an underlying illness, or as a result of injuries, such as head trauma. . Individuals in such a state have lost their thinking abilities and awareness of their surroundings, but retain non-cognitive function and normal sleep patterns. Even though those in a persistent vegetative state lose their higher brain functions, other key functions such as breathing and circulation remain relatively intact. Spontaneous movements may occur, and the eyes may open in response to external stimuli. Individuals may even occasionally grimace, cry, or laugh. Although individuals in a persistent vegetative state may appear somewhat normal, they do not speak and they are unable to respond to commands.

MalaCards based summary: Persistent Vegetative State is related to oculomotor apraxia cogan type and epileptic encephalopathy, early infantile, 3. An important gene associated with Persistent Vegetative State is SLC25A22 (Solute Carrier Family 25 Member 22). Affiliated tissues include brain, eye and lung, and related mouse phenotype taste/olfaction.

Wikipedia:68 A persistent vegetative state (PVS) is a disorder of consciousness in which patients with severe brain... more...

Related Diseases for Persistent Vegetative State

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Graphical network of the top 20 diseases related to Persistent Vegetative State:



Diseases related to persistent vegetative state

Symptoms for Persistent Vegetative State

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Drugs & Therapeutics for Persistent Vegetative State

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Drugs for Persistent Vegetative State (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
DopamineapprovedPhase 2308462-31-7, 51-61-6681
Synonyms:
(3H)-Dopamine
.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane
1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)
1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride
1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium
153C5321-5FEE-4B0B-8925-F388F0EEEBD1
2-(3,4-Dihydroxyphenyl)ethylamine
2-(3,4-dihydroxyphenyl)ethylamine
2-benzenediol
3,4-Dihydroxyphenethylamine
3,4-Dihydroxyphenethylamine hydrochloride
3,4-Dihydroxyphenylethylamine
3,4-dihydroxyphenethylamine
3-Hydroxtyramine
3-Hydroxytyramine
3-Hydroxytyramine Hydrobromide
3-Hydroxytyramine hydrochloride
4-(2-Aminoethyl)-1,
4-(2-Aminoethyl)-1,2-benzenediol
4-(2-Aminoethyl)-1,2-bezenediol
4-(2-Aminoethyl)-Pyrocatechol
4-(2-Aminoethyl)benzene-1,2-diol
4-(2-Aminoethyl)catechol
4-(2-Aminoethyl)pyrocatechol
4-(2-Aminoethyl)pyrocatechol hydrochloride
4-(2-aminoethyl)-pyrocatechol
50444-17-2
51-61-6
62-31-7 (HYDROCHLORIDE)
AC1L19S5
AC1Q54AX
AC1Q54AY
AKOS003790978
ASL 279
BIDD:ER0506
BPBio1_001123
BSPBio_001932
Biomol-NT_000001
C03758
CHEBI:18243
CHEMBL59
CID681
D07870
DB00988
Deoxyepinephrine
DivK1c_000780
Dopamin
Dopamina
Dopamina [INN-Spanish]
Dopamine
Dopamine (INN)
Dopamine (USAN)(*hydrochloride*)
Dopamine Hcl
Dopamine Hydrochloride
Dopamine [INN:BAN]
Dopaminum
Dopaminum [INN-Latin]
Dopastat
Dophamine
Dynatra
EINECS 200-110-0
HSDB 3068
Hydroxytyramin
Hydroxytyramine
IDI1_000780
IP 498
Intropin
Intropin [*hydrochloride*]
 
KBio1_000780
KBio2_001492
KBio2_002388
KBio2_002484
KBio2_004060
KBio2_004956
KBio2_005052
KBio2_006628
KBio2_007524
KBio2_007620
KBio3_001152
KBio3_002867
KBio3_002962
KBioGR_001129
KBioGR_002388
KBioGR_002484
KBioSS_001492
KBioSS_002393
KBioSS_002491
KW-3-060
L-DOPAMINE
L000232
LDP
LS-159
Lopac-H-8502
Lopac0_000586
Medopa (TN)
MolPort-001-641-000
NCGC00015519-01
NCGC00015519-08
NCGC00096050-01
NCGC00096050-02
NCGC00096050-03
NCGC00096050-04
NCGC00096050-05
NINDS_000780
NSC 173182
NSC169105
NSC173182
Oprea1_088821
Oxytyramine
Pyrocatechol, 4-(2-aminoethyl)- (8CI)
Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride
Revimine
Revivan
SPBio_001205
SPECTRUM1505155
ST048774
STK301601
Spectrum2_001023
Spectrum3_000406
Spectrum4_000525
Spectrum5_000945
Spectrum_001012
UNII-VTD58H1Z2X
UPCMLD0ENAT5885989:001
a-(3,4-Dihydroxyphenyl)-b-aminoethane
alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane
cMAP_000036
cMAP_000065
dopamine
hydroxytyramine
intropin
m-Hydroxytyramine hydrochloride
nchembio.105-comp9
nchembio.107-comp4
nchembio.284-comp1
nchembio.78-comp16
nchembio.89-comp3
nchembio705-8
nchembio801-comp8
2
Apomorphineapproved, investigationalPhase 23441372-20-76005
Synonyms:
(-)-10,11-Dihydroxyaporphine
(6AR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol
(6aR)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo(de,g)chinolin-10,11-diol
(6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol
(R)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol
(R)-5,6,6a,7-tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol
(R)-6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol
(−)-10,11-dihydroxyaporphine
314-19-2 (hydrochloride anhydrous)
41372-20-7 (hydrochloride hemihydrate)
4H-Dibenzo(de,g)quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, (R)- (9CI)
4H-Dibenzo(de,g)quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, HCl, (R)-, hemihydrate
58-00-4
6a-beta-Aporphine-10,11-diol
6a-beta-Aporphine-10,11-diol, hydrochloride, hemihydrate
6abeta-Aporphine-10,11-diol
AC1L1LLC
Apokyn
Apomorfin
Apomorphin
Apomorphine (BAN)
Apomorphine HCl hydrate
Apomorphine Hydrochloride
Apomorphine Hydrochloride Hemihydrate
Apomorphine hydrochloride
Apomorphine hydrochloride hemihydrate
Apomorphinium Chloride Hemihydrate
Apomorphinium chloride hemihydrate
Apormorphine
BPBio1_000092
BPBio1_001179
BRD-K76022557-001-01-3
BSPBio_000082
Biomol-NT_000019
C17H17NO2
 
CE0800000
CHEBI:48538
CID6005
D07460
DB00714
EINECS 200-360-0
HMS2089C10
HSDB 3289
IV Apomorphine
Ixense
L-Apomorphine
LS-21474
NCGC00025349-01
NCGC00025349-02
NIOSH/CE0800000
PDSP1_000780
PDSP2_001488
Prestwick0_000101
Prestwick1_000101
Prestwick2_000101
Prestwick3_000101
R-(-)-Apomorphine
R-(−)-apomorphine
SMP1_000027
SPBio_002021
STOCK1N-03149
Tocris-2073
UNII-N21FAR7B4S
Uprima
Uprima (TN)
VR-040
VR-400
VR004
apomorphine
nchembio.307-comp3
nchembio873-comp6
3Pharmaceutical SolutionsPhase 2, Phase 17004
4Dopamine AgentsPhase 23084
5Peripheral Nervous System AgentsPhase 218510
6Neurotransmitter AgentsPhase 214795
7Dopamine AgonistsPhase 2544
8EmeticsPhase 2164
9Gastrointestinal AgentsPhase 26401
10
Amantadineapproved65768-94-52130
Synonyms:
1-Adamantamine
1-Adamantanamine
1-Adamantanamine (8CI)
1-Adamantylamine
1-Aminoadamantane
1-Aminotricyclo(3.3.1.1(sup 3,7))decane
1-adamantanamine
1-adamantylamine
1-aminoadamantane
138576_ALDRICH
665-66-7 (hydrochloride)
768-94-5
AB00514655
AC-11992
AC1L1CZI
AC1Q4UAF
AC1Q5396
ADAMANTANE,1-AMINO
AKOS000113994
AKOS000119324
Adamantamine
Adamantanamine
Adamantylamine
Amant
Amantadina
Amantadina [INN-Spanish]
Amantadine
Amantadine (INN)
Amantadine Base
Amantadine HCL
Amantadine Hydrochloride
Amantadine [INN:BAN]
Amantadine hydrochloride
Amantadine sulfate
Amantadinum
Amantadinum [INN-Latin]
Amantidine
Ambap768-94-5
Aminoadamantane
BIA4304
BIDD:GT0757
BPBio1_000368
BRN 2204333
BSPBio_000334
BSPBio_001570
BSPBio_001822
Bio-0821
C06818
C10H17N
CHEBI:2618
CHEMBL660
CID2130
D07441
DB00915
DivK1c_000815
EINECS 212-201-2
Endantadine
Gen-Amantadine
HMS1791O12
HMS1989O12
HSDB 3202
I14-1101
IDI1_000815
InChI=1/C10H17N/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H,1-6,11H
 
KBio1_000815
KBio2_000390
KBio2_002958
KBio2_005526
KBio3_001322
KBioGR_000548
KBioSS_000390
L000868
LS-157049
Lopac-A-1260
Lopac0_000004
Mantadine
MolPort-001-661-700
MolPort-001-760-587
MolPort-001-791-102
NCGC00015036-01
NCGC00015036-07
NCGC00162039-01
NCGC00162039-02
NCGC00162039-03
NCGC00162039-04
NCGC00179597-01
NCIOpen2_001059
NINDS_000815
NSC 341865
NSC341865
NSC83653
OR14310
Oprea1_248648
Pk-merz
Prestwick0_000407
Prestwick1_000407
Prestwick2_000407
Prestwick3_000407
SPBio_000002
SPBio_002273
STK298781
Spectrum2_000081
Spectrum3_000291
Spectrum4_000134
Spectrum5_000772
Spectrum_000030
Symadine
Symmetrel
TCMDC-125869
TL8005280
Tricyclo(3.3.1.1(3,7))-decan-1-amine
Tricyclo(3.3.1.1(sup 3,7))decan-1-amine
Tricyclo(3.3.1.1(sup 3.7))decan-1-amine
Tricyclo(3.3.1.13,7)decan-1-amine
Tricyclo[3.3.1.1(3,7)]decan-1-amine
Tricyclo[3.3.1.1(3,7)]decan-1-ylamine
Tricyclo[3.3.1.1(3,7)]decane-1-amine
Tricyclo[3.3.1.1(sup3,7)]decan-1-amine
Tricyclo[3.3.1.1^3,7]decan-1-amine
UNII-BF4C9Z1J53
Viregyt
Virosol
WLN: L66 B6 A B- C 1B ITJ BZ
Wiregyt
adamantan-1-amine
adamantan-1-ylamine
amantadine
tricyclo[3.3.1.1(3,7)]decan-1-ylamine
tricyclo[3.3.1.1(3,7)]decane-1-amine
tricyclo[3.3.1.1~3,7~]decan-1-amine
11
12Contraceptives, Oral, Combined566
13Contraceptives, Oral3734
14Antiviral Agents8071
15Antiparkinson Agents1312
16Analgesics, Non-Narcotic5184
17Analgesics9358
18Anti-Infective Agents17220

Interventional clinical trials:

(show all 21)
idNameStatusNCT IDPhase
1Vagus Nerve Stimulation to Augment Recovery From Minimally Conscious or Persistently Vegetative States After Traumatic Brain InjuryRecruitingNCT01260090Phase 3
2Transcranial Direct Current Stimulation in Patients With Disorders of ConsciousnessCompletedNCT01673126Phase 2
3The Efficacy of Familiar Voice Stimulation During Coma RecoveryCompletedNCT00557076Phase 1, Phase 2
4tDCS on Precuneus in MCS: Repeated StimulationsCompletedNCT02702362Phase 2
5tDCS in MCS: Repeated StimulationsCompletedNCT02019615Phase 2
6Thalamic Stimulation of Patients in Vegetative or Minimally Conscious StateRecruitingNCT01027572Phase 2
7Fronto-parietal tDCS in Severely Brain Injured Patients With Disorders of ConsciousnessRecruitingNCT02626403Phase 2
8Efficacy Study of NH001 in Vegetative State & Minimally Conscious State Following a Traumatic Brain InjurySuspendedNCT00761228Phase 2
9The Impact of RPh201 on CVS Patients: Clinical and fMRI MeasurementsWithdrawnNCT01417299Phase 1, Phase 2
10The Impact of RPh201 on Chronic Vegetative State (CVS): fMRI StudyRecruitingNCT01438684Phase 1
11Transcranial Direct Current Stimulation Effects in Patients With Chronic Consciousness DisordersRecruitingNCT02288533Phase 1
12Effectiveness of Sensory Stimulation for Person in a Coma or Persistent Vegetative State After Traumatic Brain InjuryCompletedNCT02629588
13A Study to Tailor Advance DirectivesCompletedNCT00121004
14Navigated Brain Stimulation in Diagnosis of Minimally Conscious StateCompletedNCT01467908
15Transcranial Brain Stimulation in Vegetative State PatientsCompletedNCT01820923
16Resuscitation Registry - Surrogate Markers of Outcome After Cardiac ArrestRecruitingNCT02722460
17Study of Conscious Behavior Under Low-frequency Deep Brain Stimulation in Chronic and Severe Post-coma Disorders of ConsciousnessRecruitingNCT01718249
18Beneficial Effects of Music on Cognition and Consciousness LevelRecruitingNCT02742506
19A Pilot Study to Identify Biomarkers Associated With Chronic Traumatic Brain InjuryRecruitingNCT01171131
20Amantadine and Functional Improvement Following ABI Measured by MRI Tractography; A Pilot StudyNot yet recruitingNCT02566720
21Vagal Nerve Stimulation in Coma PatientsNot yet recruitingNCT02591069

Search NIH Clinical Center for Persistent Vegetative State

Genetic Tests for Persistent Vegetative State

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Anatomical Context for Persistent Vegetative State

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MalaCards organs/tissues related to Persistent Vegetative State:

33
Brain, Eye, Lung, Thyroid, Prostate, Breast, Liver

Animal Models for Persistent Vegetative State or affiliated genes

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MGI Mouse Phenotypes related to Persistent Vegetative State:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.3APOE, ENO2

Publications for Persistent Vegetative State

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Articles related to Persistent Vegetative State:

(show top 50)    (show all 307)
idTitleAuthorsYear
1
The Cost-Effectiveness of Pregabalin Versus Gabapentin for Peripheral Neuropathic Pain (pNeP) and Postherpetic Neuralgia (PHN) in China. (26932262)
2016
2
Zinc finger nuclease-mediated gene knockout results in loss of transport activity for P-glycoprotein, BCRP, and MRP2 in Caco-2 cells. (25388687)
2015
3
A rare cause of reversible ophthalmoplegia: tension pneumocephalus with brainstem compression. (25773200)
2015
4
COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis. (25894502)
2015
5
Docosahexaenoic acid modulates the enterocyte Caco-2 cell expression of microRNAs involved in lipid metabolism. (24623846)
2014
6
Hepatocyte growth factor activator inhibitor type 2 (HAI-2) modulates hepcidin expression by inhibiting the cell surface protease matriptase-2. (23293962)
2013
7
Lung cancer that harbors an HER2 mutation: epidemiologic characteristics and therapeutic perspectives. (23610105)
2013
8
Quality of life following surgical treatment of benign parotid disease. (24427625)
2013
9
Myofascial trigger point needling for whiplash associated pain--a feasibility study. (20580303)
2010
10
Diagnosis of acute Q fever with emphasis on enzyme-linked immunosorbent assay and nested polymerase chain reaction regarding the time of serum collection. (20846582)
2010
11
The common variant in the GSTM1 and GSTT1 genes is related to markers of oxidative stress and inflammation in patients with coronary artery disease: a case-only study. (19823950)
2010
12
Characteristics of patients with HIV and biopsy-proven acute interstitial nephritis. (20338962)
2010
13
Parents' priorities for AAC and related instruction for their children with Angelman Syndrome. (20196702)
2010
14
Epidermal growth factor receptor variant III-induced glioma invasion is mediated through myristoylated alanine-rich protein kinase C substrate overexpression. (19773446)
2009
15
Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus. (19191557)
2009
16
Enhanced CBir1-specific innate and adaptive immune responses in Crohn's disease. (18825772)
2008
17
Asymptomatic bacteriuria in the elderly: high prevalence and high turnover of strains. (18609196)
2008
18
Correlation between lymph node metastasis and the expression of VEGF-C, VEGF-D and VEGFR-3 in T1 lung adenocarcinoma. (17970036)
2007
19
Skp2 expression is associated with down-regulation of p27 protein and cell proliferation in salivary adenoid cystic carcinoma. (17431674)
2007
20
Interactions between eotaxin and interleukin-5 in the chemotaxis of primed and non-primed human eosinophils. (17368616)
2007
21
Overexpression of peptidyl-prolyl isomerase-like 1 is associated with the growth of colon cancer cells. (16397026)
2006
22
Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links. (16714450)
2006
23
Mucoepidermoid carcinoma of salivary glands in the pediatric age group: 18 clinical cases, including 11 second malignant neoplasms. (16783829)
2006
24
Comparison of the relative benefits of 2 versus 10 days of soft collar cervical immobilization after acute whiplash injury. (17084114)
2006
25
Association of cytochrome P450 2E1 genetic polymorphisms with squamous cell carcinoma of the oesophagus. (15899651)
2005
26
Agonist-dependent variablity of contributions of nitric oxide and prostaglandins in human skeletal muscle. (15563630)
2005
27
An unusual Ala12Thr polymorphism in the 1A alpha-helical segment of the companion layer-specific keratin K6hf: evidence for a risk factor in the etiology of the common hair disorder pseudofolliculitis barbae. (15086549)
2004
28
Acute myeloid leukemia associated with necrotizing temporal arteritis. (12672210)
2003
29
A randomized study comparing interferon (IFN alpha) plus low-dose cytarabine and interferon plus hydroxyurea (HU) in early chronic-phase chronic myeloid leukemia (CML). (12620292)
2003
30
PCR-based site-directed mutagenesis and recombinant expression plasmid construction of a SCN5A mutation (K317N) identified in a Chinese family with Brugada syndrome]. (14625171)
2003
31
Two common naturally occurring mutations in the human gonadotropin-releasing hormone (GnRH) receptor have differential effects on gonadotropin gene expression and on GnRH-mediated signal transduction. (12574221)
2003
32
Is epidemiology implicating extremely low frequency electric and magnetic fields in childhood leukemia? (21432262)
2002
33
20q13 and cyclin D1 in ovarian carcinomas. Analysis by fluorescence in situ hybridization. (10727982)
2000
34
Wide variation in androgen receptor dysfunction in complete androgen insensitivity syndrome. (9328206)
1997
35
The importance of microalbuminuria as an indicator of incipient diabetic nephropathy: therapeutic implications. (9453292)
1997
36
In vivo evidence for binding of p53 to consensus binding sites in the p21 and GADD45 genes in response to ionizing radiation. (9233781)
1997
37
Twenty-five years of HTLV type II follow-up with a possible case of tropical spastic paraparesis in the Kayapo, a Brazilian Indian tribe. (8947297)
1996
38
Plasminogen activator inhibitor 1 and prognosis in breast carcinoma]. (8852782)
1996
39
Cutaneous lesions provide a clue to mysterious pulmonary process. Pulmonary and cutaneous North American blastomycosis infection. (8678579)
1996
40
Antibodies against thyroid gland peroxidase and thyroglobulin in various thyroid diseases]. (8058301)
1994
41
New mechanism of action of the cancer chemotherapeutic agent 5-fluorouracil in human cells. (8169845)
1994
42
Structure of adenylate cyclase and the coupling with the receptor-G protein system]. (8384153)
1993
43
Elevation of intracellular cAMP in human T lymphocytes by an anti-CD44 mAb. (7504012)
1993
44
Cerebral amyloid angiopathy. Frequency, significance and immunohistochemistry. (7692958)
1993
45
Correlations between IL-2 enhancing activity and clinical parameters in patients with rheumatoid arthritis and systemic lupus erythematosus. (1715616)
1991
46
Genetically modified skin fibroblasts persist long after transplantation but gradually inactivate introduced genes. (1847517)
1991
47
Leiomyomatosis peritonealis disseminata. (3061357)
1988
48
Mesenchymal chondrosarcoma: a case report. (3467042)
1987
49
50

Variations for Persistent Vegetative State

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Expression for genes affiliated with Persistent Vegetative State

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Search GEO for disease gene expression data for Persistent Vegetative State.

Pathways for genes affiliated with Persistent Vegetative State

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GO Terms for genes affiliated with Persistent Vegetative State

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Cellular components related to Persistent Vegetative State according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1dendriteGO:00304259.0APOE, GABBR1
2neuronal cell bodyGO:00430258.8ENO2, GABBR1

Sources for Persistent Vegetative State

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet