Aliases & Classifications for Persistent Vegetative State

Aliases & Descriptions for Persistent Vegetative State:

Name: Persistent Vegetative State 51 52 69

Summaries for Persistent Vegetative State

NINDS : 51 A coma, sometimes also called persistent vegetative state, is a profound or deep state of unconsciousness. Persistent vegetative state is not brain-death. An individual in a state of coma is alive but unable to move or respond to his or her environment. Coma may occur as a complication of an underlying illness, or as a result of injuries, such as head trauma. . Individuals in such a state have lost their thinking abilities and awareness of their surroundings, but retain non-cognitive function and normal sleep patterns. Even though those in a persistent vegetative state lose their higher brain functions, other key functions such as breathing and circulation remain relatively intact. Spontaneous movements may occur, and the eyes may open in response to external stimuli. Individuals may even occasionally grimace, cry, or laugh. Although individuals in a persistent vegetative state may appear somewhat normal, they do not speak and they are unable to respond to commands.

MalaCards based summary : Persistent Vegetative State is related to ocular motor apraxia and epileptic encephalopathy, early infantile, 3, and has symptoms including syncope, transient alteration of awareness and other alteration of consciousness. An important gene associated with Persistent Vegetative State is GABBR1 (Gamma-Aminobutyric Acid Type B Receptor Subunit 1), and among its related pathways/superpathways are Glucose / Energy Metabolism and Neuroscience. The drugs Midazolam and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and heart, and related phenotype is taste/olfaction.

Wikipedia : 71 A persistent vegetative state (PVS) is a disorder of consciousness in which patients with severe brain... more...

Related Diseases for Persistent Vegetative State

Diseases related to Persistent Vegetative State via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)
id Related Disease Score Top Affiliating Genes
1 ocular motor apraxia 11.2
2 epileptic encephalopathy, early infantile, 3 11.1
3 panencephalitis, subacute sclerosing 11.1
4 cerebritis 10.1
5 brain injury 10.0
6 traumatic brain injury 10.0
7 dementia 9.9
8 head injury 9.9
9 budd-chiari syndrome 9.8 APOE ENO2
10 vascular dementia 9.8
11 hypoglycemia 9.8
12 breast reconstruction 9.8 APOE ENO2
13 prion disease with protracted course 9.7 APOE ENO2
14 anencephaly 9.6
15 locked-in syndrome 9.6
16 ischemia 9.6
17 sleep disorder 9.6
18 dystonia 9.6
19 neuronitis 9.6
20 encephalitis 9.6
21 alzheimer disease 9.6
22 anoxia 9.6
23 repetitive stress injuries 9.4 APOE ENO2 GABBR1 SLC25A22

Comorbidity relations with Persistent Vegetative State via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Heart Disease

Graphical network of the top 20 diseases related to Persistent Vegetative State:



Diseases related to Persistent Vegetative State

Symptoms & Phenotypes for Persistent Vegetative State

UMLS symptoms related to Persistent Vegetative State:


syncope, transient alteration of awareness, other alteration of consciousness, reduced consciousness/confusion

MGI Mouse Phenotypes related to Persistent Vegetative State:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 taste/olfaction MP:0005394 8.62 APOE ENO2

Drugs & Therapeutics for Persistent Vegetative State

Drugs for Persistent Vegetative State (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
2
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
3
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
4 Analgesics Phase 4
5 Adjuvants, Anesthesia Phase 4
6 Adrenergic Agents Phase 4
7 GABA Agents Phase 4
8 GABA Modulators Phase 4
9 Adrenergic Agonists Phase 4
10 Adrenergic alpha-2 Receptor Agonists Phase 4
11 Adrenergic alpha-Agonists Phase 4
12 Neurotransmitter Agents Phase 4,Phase 2
13 Analgesics, Non-Narcotic Phase 4
14 Tranquilizing Agents Phase 4
15 Anesthetics Phase 4
16 Anesthetics, General Phase 4
17 Anesthetics, Intravenous Phase 4
18 Peripheral Nervous System Agents Phase 4,Phase 2
19 Anti-Anxiety Agents Phase 4
20 Hypnotics and Sedatives Phase 4
21 Psychotropic Drugs Phase 4
22 Central Nervous System Depressants Phase 4
23
Dopamine Approved Phase 2 51-61-6, 62-31-7 681
24
Apomorphine Approved, Investigational Phase 2 41372-20-7, 58-00-4 6005
25 Pharmaceutical Solutions Phase 2,Phase 1
26 Dopamine Agents Phase 2
27 Dopamine agonists Phase 2
28 Gastrointestinal Agents Phase 2
29 Emetics Phase 2
30 Autonomic Agents Phase 2
31
Ethanol Approved 64-17-5 702
32
Amantadine Approved 768-94-5 2130
33 Contraceptives, Oral
34 Contraceptives, Oral, Combined
35 Fluorodeoxyglucose F18 Early Phase 1
36 Radiopharmaceuticals Early Phase 1
37 Anti-Infective Agents
38 Antiviral Agents
39 Antiparkinson Agents

Interventional clinical trials:

(show all 29)
id Name Status NCT ID Phase
1 Is Sensory Stimulation Effective in Reducing Time Spent in a Coma or Vegetative State Unknown status NCT00163878 Phase 4
2 Dexmedetomidine vs Midazolam for Intraoperative Sedation Completed NCT02878837 Phase 4
3 Vagus Nerve Stimulation to Augment Recovery From Minimally Conscious or Persistently Vegetative States After Traumatic Brain Injury Unknown status NCT01260090 Phase 3
4 Two Intensities of Transcranial Direct Current Stimulation to Improve Consciousness in Severely Brain Injured Patients Recruiting NCT03007784 Phase 3
5 Thalamic Stimulation of Patients in Vegetative or Minimally Conscious State Unknown status NCT01027572 Phase 2
6 tDCS on Precuneus in MCS: Repeated Stimulations Completed NCT02702362 Phase 2
7 The Efficacy of Familiar Voice Stimulation During Coma Recovery Completed NCT00557076 Phase 1, Phase 2
8 Transcranial Direct Current Stimulation in Patients With Disorders of Consciousness Completed NCT01673126 Phase 2
9 Efficacy Study of NH001 in Vegetative State & Minimally Conscious State Following a Traumatic Brain Injury Suspended NCT00761228 Phase 2
10 The Impact of RPh201 on CVS Patients: Clinical and fMRI Measurements Withdrawn NCT01417299 Phase 1, Phase 2
11 The Impact of RPh201 on Chronic Vegetative State (CVS): fMRI Study Recruiting NCT01438684 Phase 1
12 Study of Conscious Behavior Under Low-frequency Deep Brain Stimulation in Chronic and Severe Post-coma Disorders of Consciousness Unknown status NCT01718249
13 Effectiveness of Sensory Stimulation for Person in a Coma or Persistent Vegetative State After Traumatic Brain Injury Completed NCT02629588
14 A Study to Tailor Advance Directives Completed NCT00121004
15 Transcranial Brain Stimulation in Vegetative State Patients Completed NCT01820923
16 Further Psychometric Data for the Reliability and the Diagnostic Validity of CRS-R Completed NCT03126929
17 Pupil Near Response in UWS Patients Completed NCT02832492
18 Personalized Objects Can Improve the Diagnosis of EMCS From MCS Completed NCT02988206
19 Navigated Brain Stimulation in Diagnosis of Minimally Conscious State Completed NCT01467908
20 Analysis of Vital, Facial and Muscular Responses Front to Music or Message in Coma, Vegetative State or Sedated Patients Completed NCT01141790
21 tDCS in MCS: Repeated Stimulations Completed NCT02019615
22 Transcranial Direct Current Stimulation Effects in Patients With Chronic Consciousness Disorders Completed NCT02288533
23 18F-FDG PET/CT in Diagnostic Patients of Disorder of Consciousness Recruiting NCT02999490 Early Phase 1
24 Resuscitation Registry - Surrogate Markers of Outcome After Cardiac Arrest Recruiting NCT02722460
25 Fronto-parietal tDCS in Severely Brain Injured Patients With Disorders of Consciousness Recruiting NCT02626403
26 Vagal Nerve Stimulation in Coma Patients Recruiting NCT02591069
27 Beneficial Effects of Music on Cognition and Consciousness Level Recruiting NCT02742506
28 A Pilot Study to Identify Biomarkers Associated With Chronic Traumatic Brain Injury Recruiting NCT01171131
29 Amantadine and Functional Improvement Following ABI Measured by MRI Tractography; A Pilot Study Not yet recruiting NCT02566720

Search NIH Clinical Center for Persistent Vegetative State

Genetic Tests for Persistent Vegetative State

Anatomical Context for Persistent Vegetative State

MalaCards organs/tissues related to Persistent Vegetative State:

39
Brain, Eye, Heart, Pituitary, Spinal Cord, Thalamus

Publications for Persistent Vegetative State

Articles related to Persistent Vegetative State:

(show top 50) (show all 310)
id Title Authors Year
1
Ascending Reticular Activating System in a Patient with Persistent Vegetative State. ( 26745220 )
2016
2
Effectiveness of Sensory Stimulation to Improve Arousal and Alertness of People in a Coma or Persistent Vegetative State After Traumatic Brain Injury: A Systematic Review. ( 27089287 )
2016
3
Open traumatic brain injury by nail gun resulting in a persistent vegetative state. ( 27044613 )
2016
4
Persistent vegetative state and minimally conscious state. ( 25891806 )
2015
5
Should patients in a persistent vegetative state be allowed to die? Guidelines for a new standard of care in Australian hospitals. ( 26507136 )
2015
6
Magnetic resonance imaging characteristics of persistent vegetative state due to prolonged hypoglycemia. ( 25738058 )
2015
7
Brainstem neurons survive the identical ischemic stress that kills higher neurons: insight to the persistent vegetative state. ( 24802253 )
2014
8
Causes and outcomes of persistent vegetative state in a Chinese versus American referral hospital. ( 23099847 )
2013
9
Zolpidem Arousing Effect In Persistent Vegetative State Patients: Autonomic, Eeg And Behavioral Assessment. ( 24025063 )
2013
10
Ethics and Health Policy of Dialyzing a Patient in a Persistent Vegetative State. ( 24115197 )
2013
11
From hope to despair, and back: being the wife of a patient in a persistent vegetative state. ( 23188382 )
2013
12
Responsiveness of a patient in a persistent vegetative state after a coma to weekly injections of autologous activated immune cells: a case report. ( 22234176 )
2012
13
A Cuban perspective on management of persistent vegetative state. ( 22334112 )
2012
14
Focal increase in cerebral blood flow after treatment with near-infrared light to the forehead in a patient in a persistent vegetative state. ( 22047598 )
2012
15
Court case adjourned after diagnosis of persistent vegetative state changes. ( 22930714 )
2012
16
Persistent vegetative state: an ethical reappraisal. ( 22131038 )
2012
17
Characteristics of infradian and circadian rhythms in the persistent vegetative state. ( 22289544 )
2011
18
More dead than dead: perceptions of persons in the persistent vegetative state. ( 21798528 )
2011
19
A long-term intensive behavioral treatment study in patients with persistent vegetative state or minimally conscious state. ( 21305239 )
2011
20
Measuring interconnection of the residual cortical functional islands in persistent vegetative state and minimal conscious state with EEG nonlinear analysis. ( 21530389 )
2011
21
Covert cognition in the persistent vegetative state. ( 20138110 )
2010
22
In the name of good intentions: nurses' perspectives on caring for a pregnant patient in a persistent vegetative state. ( 20124019 )
2010
23
Persistent vegetative state. ( 20132712 )
2010
24
Zolpidem for persistent vegetative state--a placebo-controlled trial in pediatrics. ( 21210338 )
2010
25
The place of L-dopa/carbidopa in persistent vegetative state. ( 21060281 )
2010
26
Are people in a persistent vegetative state conscious? ( 20069822 )
2009
27
Dorsal column stimulation in persistent vegetative state. ( 22151220 )
2009
28
Intrathecal baclofen in patients with persistent vegetative state: 2 hypotheses. ( 19577040 )
2009
29
Cortical sources of resting-state alpha rhythms are abnormal in persistent vegetative state patients. ( 19299197 )
2009
30
Media coverage of the persistent vegetative state and end-of-life decision-making: Theresa Schiavo's tragedy and ours, too. ( 19752461 )
2009
31
Persistent vegetative state in electrical injuries: a 10-year review. ( 17913369 )
2008
32
A MRS-MRI-fMRI exploration of the brain. Impact of long-lasting persistent vegetative state. ( 18240041 )
2008
33
Media coverage of the persistent vegetative state and end-of-life decision-making. ( 18685135 )
2008
34
Prevention of venous thromboembolism and persistent vegetative state: A medical and an ethical issue. ( 18549951 )
2008
35
Heart rate non linear dynamics in patients with persistent vegetative state: a preliminary report. ( 18183507 )
2008
36
Caring for children in a persistent vegetative state: complex but manageable. ( 17873785 )
2007
37
Persistent vegetative state. ( 17485655 )
2007
38
Ethics consultants' recommendations for life-prolonging treatment of patients in persistent vegetative state: a follow-up study. ( 17546936 )
2007
39
Recognizing a mother's voice in the persistent vegetative state. ( 17844939 )
2007
40
Pascal's Wager and the persistent vegetative state. ( 17845492 )
2007
41
EEG findings in the persistent vegetative state. ( 18090523 )
2007
42
The experiences of pediatric nurses caring for children in a persistent vegetative state. ( 17693906 )
2007
43
Terminating artificial nutrition and hydration in persistent vegetative state patients: current and proposed state laws. ( 17242347 )
2007
44
Diagnostic criteria for persistent vegetative state. ( 23217994 )
2007
45
Intrathecal baclofen in the treatment of post-stroke central pain, dystonia, and persistent vegetative state. ( 17691381 )
2007
46
Dorsal column stimulation for persistent vegetative state. ( 17691409 )
2007
47
Does any aspect of mind survive brain damage that typically leads to a persistent vegetative state? Ethical considerations. ( 18086316 )
2007
48
Persistent vegetative state and dementia in the elderly. ( 17234039 )
2007
49
The influence of acoustic and tactile stimulation on vegetative parameters and EEG in persistent vegetative state. ( 17925166 )
2007
50
Reflections on the papal allocution concerning care for persistent vegetative state patients. ( 16830415 )
2006

Variations for Persistent Vegetative State

Expression for Persistent Vegetative State

Search GEO for disease gene expression data for Persistent Vegetative State.

Pathways for Persistent Vegetative State

Pathways related to Persistent Vegetative State according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.42 APOE ENO2
2 11.31 APOE ENO2 GABBR1

GO Terms for Persistent Vegetative State

Sources for Persistent Vegetative State

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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