MCID: PRS038
MIFTS: 59

Personality Disorder malady

Mental diseases category
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Summaries for Personality Disorder

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MedlinePlus:33 Personality disorders are a group of mental illnesses. they involve long-term patterns of thoughts and behaviors that are unhealthy and inflexible. the behaviors cause serious problems with relationships and work. people with personality disorders have trouble dealing with everyday stresses and problems. they often have stormy relationships with other people. the cause of personality disorders is unknown. however, genes and childhood experiences may play a role. the symptoms of each personality disorder are different. they can mild or severe. people with personality disorders may have trouble realizing that they have a problem. to them, their thoughts are normal, and they often blame others for their problems. they may try to get help because of their problems with relationships and work. treatment usually includes talk therapy and sometimes medicine.

MalaCards based summary: Personality Disorder, also known as personality disorders, is related to borderline personality disorder and obsessive-compulsive personality disorder. An important gene associated with Personality Disorder is TTF2 (transcription termination factor, RNA polymerase II), and among its related pathways are Dopamine metabolism and Serotonin clearance from the synaptic cleft. The compounds mhpg and minaprine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related mouse phenotypes are endocrine/exocrine gland and muscle.

Disease Ontology:8 A disease of mental health that involve long-term patterns of thoughts and behaviors that cause serious problems with relationships and work.

Wikipedia:65 Personality disorders are a class of mental disorders characterized by enduring maladaptive patterns of... more...

Aliases & Classifications for Personality Disorder

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Personality Disorder, Aliases & Descriptions:

Name: Personality Disorder 8
Personality Disorders 44 33 62
 
Character Disorder 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:1510
ICD9CM27 301.89, 301.8
ICD1025 F60, F60.9

Related Diseases for Personality Disorder

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Diseases in the Personality Disorder family:

Multiple Personality Disorder

Diseases related to Personality Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1borderline personality disorder31.5TTF2, CLPS, HTR1B, MAOA, SLC6A4
2obsessive-compulsive personality disorder31.5SLC6A4, CLPS
3schizophrenia31.3HTR2A, COMT
4anxiety disorder31.2SLC6A4, MAOA
5social phobia31.1COMT, MAOA, SLC6A4
6substance abuse31.0SLC6A3, SLC6A4
7intermittent explosive disorder31.0HTR1B
8bipolar disorder30.9SLC6A4, HTR2A
9pathological gambling30.9SLC6A3
10substance dependence30.7COMT, SLC6A4, SLC6A3
11cocaine dependence30.7SLC6A3, SLC6A4
12antisocial personality disorder30.7HTR1B, MAOA, SLC6A4, SLC6A3, HTR2A, TTF2
13dysthymic disorder30.7HTR2A, MAOA
14paranoid schizophrenia30.7COMT
15melancholia30.5MAOA
16chronic fatigue syndrome30.4MAOA, SLC6A4
17alcohol dependence30.4HTR2A, HTR1B, MAOA, SLC6A4
18nicotine dependence30.4SLC6A4
19oppositional defiant disorder30.3SLC6A3
20conduct disorder30.2TTF2, COMT, MAOA, SLC6A4, SLC6A3
21anorexia nervosa30.2SLC6A4, MAOA, COMT, HTR2A
22drug dependence30.2SLC6A3, SLC6A4, MAOA
23seasonal affective disorder30.2HTR2A, SLC6A4
24eating disorder30.2HTR2A, COMT, SLC6A4, SLC6A3
25cocaine abuse30.1SLC6A3, SLC6A4
26generalized anxiety disorder30.1SLC6A4, MAOA, HTR2A
27bulimia nervosa30.1HTR2A, HTR1B, COMT, MAOA, SLC6A4
28panic disorder30.0TTF2, HTR2A, COMT, MAOA, SLC6A4
29alcohol abuse30.0SLC6A3, SLC6A4, COMT
30asthma29.9HTR2A, TTF2
31schizoaffective disorder29.8HTR2A, COMT, SLC6A4
32parkinson's disease29.6SLC6A3, MAOA, COMT
33obsessive-compulsive disorder29.5TTF2, HTR2A, HTR1B, COMT, MAOA, SLC6A4
34dementia29.4TTF2, HTR2A, COMT, MAOA, SLC6A3
35mood disorder29.4SLC6A3, SLC6A4, MAOA, COMT, HTR1B, HTR2A
36attention deficit hyperactivity disorder29.3TTF2, HTR2A, HTR1B, COMT, MAOA, SLC6A4
37obesity29.2TTF2, CLPS, HTR2A, COMT, MAOA, SLC6A3
38psychotic disorder29.1SLC6A3, SLC6A4, MAOA, COMT, HTR2A, TTF2
39migraine28.9HTR1B, HTR2A, COMT, MAOA, SLC6A4, SLC6A3
40alzheimer's disease28.8TTF2, HTR2A, COMT, MAOA, SLC6A4, SLC6A3
41multiple personality disorder11.1
42schizotypal personality disorder11.0
43narcissistic personality disorder10.9
44avoidant personality disorder10.9
45dependent personality disorder10.6
46histrionic personality disorder10.6
47paranoid personality disorder10.6
48schizoid personality disorder10.5
49alcoholic psychosis10.5SLC6A4
50premature ejaculation10.5SLC6A4

Graphical network of the top 20 diseases related to Personality Disorder:



Diseases related to personality disorder

Symptoms for Personality Disorder

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Drugs & Therapeutics for Personality Disorder

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Drug clinical trials:

Search ClinicalTrials for Personality Disorder

Search NIH Clinical Center for Personality Disorder

Genetic Tests for Personality Disorder

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Anatomical Context for Personality Disorder

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MalaCards organs/tissues related to Personality Disorder:

32
Brain, Testes, Eye, Temporal lobe, Amygdala, Bone, Caudate nucleus, Cortex, Pituitary, Heart, Prefrontal cortex, Breast, Ovary, Endothelial, Thalamus

Animal Models for Personality Disorder or affiliated genes

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MGI Mouse Phenotypes related to Personality Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.1SLC6A3, SLC6A4, HTR1B, HTR2A
2MP:00053697.8HTR2A, HTR1B, SLC6A4, SLC6A3
3MP:00053866.6SLC6A3, SLC6A4, MAOA, COMT, HTR1B, HTR2A

Publications for Personality Disorder

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Articles related to Personality Disorder:

(show top 50)    (show all 1786)
idTitleAuthorsYear
1
Beyond the diagnostic traits: A collaborative exploratory diagnostic process for dimensions and underpinnings of narcissistic personality disorder. (25314232)
2014
2
Stability of narcissistic personality disorder: tracking categorical and dimensional rating systems over a two-year period. (24512458)
2014
3
'It's One of the Hardest Jobs in the World': The Experience and Understanding of Qualified Nurses Who Work with Individuals Diagnosed with Both Learning Disability and Personality Disorder. (25196279)
2014
4
Changes in low-frequency fluctuations in patients with antisocial personality disorder revealed by resting-state functional MRI. (24598769)
2014
5
Doing Psychiatry Right: A Case of Severe Avoidant Personality Disorder with Obsessive-compulsive Personality Disorder, Obsessive Compulsive Disorder, Intermittent Explosive Disorder and Sexual Paraphilias. (25035563)
2014
6
Emotional cascades as prospective predictors of dysregulated behaviors in borderline personality disorder. (23046043)
2013
7
Distinguishing bipolar II depression from major depressive disorder with comorbid borderline personality disorder: demographic, clinical, and family history differences. (24107761)
2013
8
A developing world perspective on homicide and personality disorder. (24166685)
2013
9
Medial prefrontal dysfunction and prolonged amygdala response during instructed fear processing in borderline personality disorder. (22404662)
2013
10
Schizotypal personality disorder. (22928856)
2013
11
A Further Validation of the Minnesota Borderline Personality Disorder Scale. (24364505)
2013
12
Comorbidity of social anxiety disorder and antisocial personality disorder in the National Epidemiological Survey on Alcohol and Related Conditions (NESARC). (24384071)
2013
13
A Case of Depressive Personality Disorder: Aligning Theory, Practice, and Clinical Research. (23957236)
2013
14
Getting the word out about treating borderline personality disorder: an online information resource. (23334680)
2013
15
Alexithymia as a mediator between attachment and the development of borderline personality disorder in adolescence. (23013337)
2012
16
Gender Differences in a Clinical Sample of Patients with Borderline Personality Disorder. (22494170)
2012
17
The association of 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR gene polymorphisms and antisocial personality disorder in male heroin-dependent Chinese subjects. (22138326)
2012
18
Management of borderline personality disorder. (23027916)
2012
19
Avoidant personality disorder in individuals with generalized social anxiety disorder: what does it add? (22705954)
2012
20
Platelet protein kinase C and brain-derived neurotrophic factor levels in borderline personality disorder patients. (22633012)
2012
21
Diagnosis of antisocial personality disorder and criminal responsibility. (21903271)
2011
22
Antisocial personality disorder is on a continuum with psychopathy. (20579518)
2010
23
Diagnosis and subtypes of adolescent antisocial personality disorder. (20420477)
2010
24
Incremental effect for antisocial personality disorder genetic risk combining 5-HTTLPR and 5-HTTVNTR polymorphisms. (20363030)
2010
25
Factor structure and diagnostic efficiency of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria for avoidant personality disorder in Hispanic men and women with substance use disorders. (19683617)
2009
26
5-HT1A receptor gene C -1019 G polymorphism and amygdala volume in borderline personality disorder. (18387137)
2008
27
Clozapine in treatment-refractory obsessive-compulsive disorder with comorbid schizotypal personality disorder. (19398826)
2008
28
A time series evaluation of the treatment of histrionic personality disorder with cognitive analytic therapy. (17877864)
2007
29
Similar or disparate brain patterns? The intra-personal EEG variability of three women with multiple personality disorder. (16929711)
2006
30
Etiology of antisocial personality disorder: benefits for society from an evolutionary standpoint. (16006050)
2005
31
Borderline personality disorder, antisocial personality disorder and risk-taking among heroin users: findings from the Australian Treatment Outcome Study (ATOS). (15072810)
2004
32
The role of personality disorders on drug dependence treatment outcomes following inpatient detoxification. (15196598)
2004
33
Misdiagnosis of Asperger syndrome as anankastic personality disorder. (12540134)
2002
34
Neuropsychological performance in schizotypal personality disorder: evidence regarding diagnostic specificity. (12488063)
2002
35
Diagnosing antisocial personality disorder among substance abusers: the scid versus the MCMI-II. (11727884)
2001
36
Schizotypal personality disorder and MRI abnormalities of temporal lobe gray matter. (10356620)
1999
37
Gender differences in the relationship of antisocial personality disorder criteria to Psychopathy Checklist-Revised scores. (9573521)
1998
38
Acute and transient psychotic disorder: comorbidity with personality disorder. (9021000)
1996
39
Death rates in 71 men with antisocial personality disorder. A comparison with general population mortality. (8742541)
1996
40
m-Chlorophenylpiperazine challenge in borderline personality disorder: relationship of neuroendocrine response, behavioral response, and clinical measures. (8879471)
1996
41
Schizoid personality disorder after prenatal exposure to famine. (8942466)
1996
42
Antisocial personality disorder as a prognostic factor for pharmacotherapy of cocaine dependence. (8082553)
1994
43
Child abuse and multiple personality disorder. (8185019)
1994
44
Drinking outcomes of alcohol abusers diagnosed as antisocial personality disorder. (7978086)
1994
45
Multiple personality disorder and satanic ritual abuse. (8135697)
1993
46
Expressive therapy in conjunction with psychotherapy in the treatment of persons with multiple personality disorder. (2252072)
1990
47
Multiple personality disorder. (2611585)
1989
48
Autohypnotic resolution of an incipient relapse in an integrated multiple personality disorder patient: a clinical note. (3228064)
1988
49
The relationship of histrionic personality disorder to antisocial personality and somatization disorders. (3717392)
1986
50
Clinical phobias and avoidant personality disorder among alcoholics admitted to an alcoholism rehabilitation setting. (3791123)
1986

Variations for Personality Disorder

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Expression for genes affiliated with Personality Disorder

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Expression patterns in normal tissues for genes affiliated with Personality Disorder

Search GEO for disease gene expression data for Personality Disorder.

Pathways for genes affiliated with Personality Disorder

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Pathways related to Personality Disorder according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6COMT, MAOA
2
Show member pathways
9.6COMT, MAOA
3
Show member pathways
catecholamine biosynthesis37
9.6MAOA, COMT
4
Show member pathways
phenylalanine utilization37
noradrenaline and adrenaline degradation37
phenylalanine degradation IV37
9.6MAOA, COMT
59.6MAOA, COMT
69.6MAOA, COMT
7
Show member pathways
9.3HTR1B, HTR2A
8
Show member pathways
9.3SLC6A3, MAOA
99.1SLC6A4, MAOA, HTR2A
10
Show member pathways
Serotonin Transporter Activity37
8.9SLC6A3, SLC6A4, MAOA
11
Show member pathways
8.8COMT, MAOA, SLC6A3
128.5HTR2A, HTR1B, MAOA, SLC6A4
13
Show member pathways
7.3SLC6A3, SLC6A4, MAOA, COMT, HTR1B, HTR2A

Compounds for genes affiliated with Personality Disorder

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Compounds related to Personality Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 172)
idCompoundScoreTop Affiliating Genes
1mhpg449.4MAOA, COMT, SLC6A4
2minaprine44 1110.4SLC6A4, HTR2A, MAOA
3naratriptan44 28 1111.3HTR2A, HTR1B, MAOA
4mcpp449.2HTR2A, HTR1B, SLC6A4
5carbon-11449.2SLC6A3, SLC6A4, MAOA
6p-chloroamphetamine449.2SLC6A3, MAOA, SLC6A4
7phentermine44 1110.2SLC6A3, MAOA, SLC6A4
8d amphetamine449.2SLC6A4, SLC6A3, MAOA
9pindolol44 28 1111.2HTR2A, HTR1B, SLC6A4
10pseudoephedrine44 24 1111.2SLC6A3, SLC6A4, MAOA
11mdma449.1MAOA, SLC6A4, SLC6A3
12maprotiline44 50 1111.1SLC6A4, SLC6A3, MAOA
13methysergide44 28 1111.1HTR2A, HTR1B, MAOA
14tryptamine44 28 2411.0HTR2A, HTR1B, MAOA
15Serotonin249.0HTR1B, HTR2A, SLC6A4, MAOA
16amine448.9COMT, HTR1B, SLC6A4, MAOA
17duloxetine44 50 28 1111.9HTR2A, SLC6A4, SLC6A3
18fenfluramine44 28 1110.9HTR2A, SLC6A4, HTR1B
19ropinirole44 119.9COMT, HTR2A, HTR1B
20methylphenidate44 50 1110.8SLC6A4, MAOA, SLC6A3, COMT
21tyramine44 28 2410.8SLC6A4, MAOA, COMT, SLC6A3
22methamphetamine44 50 1110.8SLC6A3, COMT, SLC6A4, MAOA
23mianserin44 28 1110.8HTR2A, MAOA, SLC6A4
24trimipramine44 50 1110.8SLC6A4, SLC6A3, HTR2A
25mptp448.8SLC6A4, COMT, MAOA, SLC6A3
26amitriptyline44 28 50 1111.6SLC6A4, HTR2A, MAOA, SLC6A3
27desipramine44 50 1110.6HTR2A, MAOA, SLC6A4, SLC6A3
28citalopram44 50 24 1111.6MAOA, SLC6A4, SLC6A3, HTR2A
29imipramine44 28 50 24 1112.6SLC6A3, SLC6A4, MAOA, HTR2A
30levodopa44 119.5HTR1B, COMT, MAOA, SLC6A3
31nefazodone44 50 1110.5SLC6A4, SLC6A3, HTR1B, HTR2A
32escitalopram44 50 24 1111.5SLC6A4, HTR2A, SLC6A3
33quetiapine44 50 28 24 1112.5HTR2A, HTR1B, SLC6A4, SLC6A3
34pramipexole44 28 50 1111.5COMT, SLC6A3, HTR1B, HTR2A
35carbon448.5COMT, TTF2, SLC6A4, SLC6A3, MAOA
36nicotine44 28 50 1111.5MAOA, TTF2, COMT, SLC6A4, SLC6A3
37apomorphine28 44 1110.5HTR2A, HTR1B, COMT, SLC6A3
38bromocriptine44 28 1110.4SLC6A3, COMT, HTR1B, HTR2A
39fluvoxamine44 50 1110.2MAOA, COMT, HTR2A, SLC6A4, SLC6A3
40clomipramine44 50 1110.2SLC6A3, SLC6A4, MAOA, HTR1B, HTR2A
41fluoxetine44 50 28 1111.2SLC6A3, SLC6A4, HTR1B, MAOA, HTR2A
42venlafaxine44 50 24 1111.1SLC6A3, HTR2A, HTR1B, COMT, SLC6A4
43risperidone44 50 28 61 24 1113.1SLC6A3, SLC6A4, COMT, HTR1B, HTR2A
44olanzapine44 50 28 24 1112.1HTR2A, SLC6A3, SLC6A4, COMT, HTR1B
45norepinephrine44 24 1110.1HTR2A, COMT, SLC6A4, SLC6A3, MAOA
46clozapine44 28 50 1111.1COMT, HTR1B, SLC6A4, SLC6A3, HTR2A
47maoa447.7SLC6A4, HTR2A, HTR1B, COMT, MAOA, SLC6A3
48paroxetine44 50 28 1110.7HTR2A, SLC6A3, HTR1B, COMT, MAOA, SLC6A4
495-hydroxytryptamine447.7HTR2A, HTR1B, SLC6A3, SLC6A4, COMT, MAOA
50dopamine44 28 24 1110.7SLC6A4, MAOA, SLC6A3, HTR2A, COMT, HTR1B

GO Terms for genes affiliated with Personality Disorder

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Cellular components related to Personality Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.1SLC6A3, SLC6A4, HTR1B, HTR2A

Biological processes related to Personality Disorder according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1neurotransmitter catabolic processGO:0421359.8MAOA, COMT
2vasoconstrictionGO:0423109.4SLC6A4, HTR1B
3regulation of dopamine secretionGO:0140599.4HTR1B, HTR2A
4memoryGO:0076139.4SLC6A4, HTR2A
5monoamine transportGO:0158449.4SLC6A4, SLC6A3
6negative regulation of synaptic transmission, glutamatergicGO:0519679.4HTR1B, HTR2A
7regulation of behaviorGO:0507959.3HTR2A, HTR1B
8dopamine catabolic processGO:0424209.1SLC6A3, MAOA, COMT
9neurotransmitter biosynthetic processGO:0421369.1SLC6A3, MAOA, COMT
10response to cocaineGO:0422208.8SLC6A3, HTR1B
11response to drugGO:0424938.4SLC6A3, SLC6A4, COMT, HTR2A
12synaptic transmissionGO:0072687.9HTR2A, HTR1B, COMT, MAOA, SLC6A3

Molecular functions related to Personality Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serotonin receptor activityGO:0049939.3HTR1B, HTR2A
2monoamine transmembrane transporter activityGO:0085049.1SLC6A3, SLC6A4
3serotonin bindingGO:0513789.0HTR1B, HTR2A
4drug bindingGO:0081448.5SLC6A3, HTR1B, HTR2A

Products for genes affiliated with Personality Disorder

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  • Antibodies
  • Proteins
  • Lysates

Sources for Personality Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet