MCID: PRS038
MIFTS: 64

Personality Disorder malady

Neuronal diseases category

Summaries for Personality Disorder

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Personality disorders are a group of mental illnesses. they involve long-term patterns of thoughts and behaviors that are unhealthy and inflexible. the behaviors cause serious problems with relationships and work. people with personality disorders have trouble dealing with everyday stresses and problems. they often have stormy relationships with other people. the cause of personality disorders is unknown. however, genes and childhood experiences may play a role. the symptoms of each personality disorder are different. they can mild or severe. people with personality disorders may have trouble realizing that they have a problem. to them, their thoughts are normal, and they often blame others for their problems. they may try to get help because of their problems with relationships and work. treatment usually includes talk therapy and sometimes medicine.

MalaCards: Personality Disorder, also known as personality disorders, is related to borderline personality disorder and antisocial personality disorder. An important gene associated with Personality Disorder is TTF2 (transcription termination factor, RNA polymerase II), and among its related pathways are Enzymatic degradation of dopamine by COMT and melatonin degradation II. The compounds mdma and pergolide have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related mouse phenotypes are adipose tissue and cardiovascular system.

Disease Ontology:8 A disease of mental health that involve long-term patterns of thoughts and behaviors that cause serious problems with relationships and work.

Wikipedia:63 Personality disorders are a class of mental disorders characterised by enduring maladaptive patterns of... more...

Aliases & Classifications for Personality Disorder

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8Disease Ontology, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

personality disorder 8
personality disorders 44 33 60
character disorder 8


External Ids:

Disease Ontology8 DOID:1510
ICD9CM27 301.8, 301.89
ICD1025 F60, F60.9

Related Diseases for Personality Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Personality Disorder family:

Multiple Personality Disorder

Diseases related to Personality Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 149)
idRelated DiseaseScoreTop Affiliating Genes
1borderline personality disorder31.8MAOA, CLPS, TTF2, SLC6A4, TPH1, FLNA
2antisocial personality disorder31.6TTF2, SLC6A3, SLC6A4, MAOA, ANKK1, HTR1B
3schizotypal personality disorder31.4COMT, LBR, FLNA
4dependent personality disorder31.2KNTC1
5obsessive-compulsive personality disorder31.1SLC6A4, CLPS
6obsessive-compulsive disorder31.0COMT, HTR1B, HTR2A, DRD2, DRD3, DRD4
7schizophrenia31.0COMT, HTR2A, DRD3
8social phobia30.9SLC6A4, MAOA, DRD2, COMT
9bipolar disorder30.8HTR2A, DRD2, SLC6A4
10substance dependence30.8COMT, DRD2, DRD3, DRD4, SLC6A3, SLC6A4
11anxiety disorder30.7TPH2, TPH1, SLC6A4, MAOA
12substance abuse30.7DRD2, DRD3, DRD4, SLC6A3, SLC6A4
13conduct disorder30.7COMT, DRD2, DRD4, MAOA, TTF2, SLC6A3
14eating disorder30.6COMT, HTR2A, SLC6A3, SLC6A4
15alexithymia30.6ANKK1
16cocaine dependence30.6DRD2, DRD3, SLC6A3, SLC6A4
17alcohol dependence30.6HTR1B, HTR2A, DRD2, DRD4, ANKK1, MAOA
18bulimia nervosa30.5COMT, HTR1B, HTR2A, MAOA, SLC6A4
19panic disorder30.5TPH1, TPH2, SLC6A4, TTF2, COMT, HTR2A
20attention deficit hyperactivity disorder30.5DRD4, SLC6A3
21mood disorder30.5COMT, HTR1B, HTR2A, DRD2, DRD3, DRD4
22heroin dependence30.4DRD2, DRD4, ANKK1
23pathological gambling30.4DRD2, DRD3, DRD4, SLC6A3
24anorexia nervosa30.4COMT, HTR2A, DRD4, PRL, MAOA, SLC6A4
25alcohol abuse30.3COMT, DRD2, DRD3, SLC6A3, SLC6A4
26paranoid schizophrenia30.3COMT
27generalized anxiety disorder30.3HTR2A, MAOA, SLC6A4, TPH1
28dysthymic disorder30.3HTR2A, MAOA
29drug dependence30.3DRD2, DRD3, MAOA, SLC6A3, SLC6A4
30obesity30.2COMT, HTR2A, DRD2, DRD4, MAOA, MAOB
31psychotic disorder30.2COMT, HTR2A, DRD2, DRD3, DRD4, PRL
32autistic disorder29.9SLC6A4, DRD4
33chronic fatigue syndrome29.9SLC6A4, MAOA, LBR
34cocaine abuse29.9SLC6A4, SLC6A3, DRD2
35seasonal affective disorder29.9HTR2A, DRD4, SLC6A4, TPH1
36nicotine dependence29.9DRD2, DRD4, ANKK1, SLC6A4
37dementia29.9COMT, HTR2A, MAOA, MAOB, TTF2, SLC6A3
38migraine29.9HTR1B, HTR2A, DRD2, DRD3, DRD4, MAOA
39alcoholic psychosis29.7SLC6A4
40melancholia29.7MAOA
41delusional disorder29.7DRD4, DRD2
42parkinson's disease29.7COMT, SLC6A3, MAOB, MAOA, DRD3, DRD2
43opiate dependence29.7DRD2, DRD3
44schizoaffective disorder29.7DRD2, DRD3, DRD4, PRL, SLC6A4, HTR2A
45alzheimer's disease29.7COMT, HTR2A, LBR, DRD2, DRD3, DRD4
46multiple personality disorder11.0
47narcissistic personality disorder10.8
48avoidant personality disorder10.8
49histrionic personality disorder10.6
50major depressive disorder10.5

Graphical network of the top 20 diseases related to Personality Disorder:



Diseases related to personality disorder

Clinical Features for Personality Disorder

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Drugs & Therapeutics for Personality Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Personality Disorder

Drug clinical trials:

Search ClinicalTrials for Personality Disorder

Search NIH Clinical Center for Personality Disorder

Search CenterWatch for Personality Disorder

Genetic Tests for Personality Disorder

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Anatomical Context for Personality Disorder

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32MalaCards
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MalaCards organs/tissues related to Personality Disorder:

32
Brain, Testes, Eye, Temporal lobe, Bone, Amygdala, Caudate nucleus, Pituitary, Cortex, Heart, Prefrontal cortex, Breast, Thyroid, Ovary, Thalamus, Endothelial

Animal Models for Personality Disorder or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Personality Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537510.1TPH2, LBR, TPH1, CLPS, DRD3, DRD2
2MP:000538510.0TPH1, SLC6A4, MAOA, FLNA, DRD3, DRD2
3MP:001077110.0LBR, DRD2, PRL, CLPS, SLC6A3, TPH1
4MP:000539010.0HTR2A, LBR, DRD2, FLNA, SLC6A3, TPH1
5MP:00036319.8DRD4, DRD2, PRL, MAOA, MAOB, SLC6A3
6MP:00053799.7HTR1B, HTR2A, LBR, DRD2, SLC6A3, SLC6A4
7MP:00053769.7PRL, MAOA, MAOB, FLNA, DRD4, DRD3
8MP:00053789.7DRD2, DRD3, SLC6A4, FLNA, CLPS, SLC6A3
9MP:00053869.7HTR2A, DRD3, COMT, TPH2, TPH1, SLC6A4

Publications for Personality Disorder

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50PubMed
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Articles related to Personality Disorder:

(show top 50)    (show all 1946)
idTitleAuthorsYear
1
Trait anxiety modulates fronto-limbic processing of emotional interference in borderline personality disorder. (23459637)
2013
2
Personality traits as vulnerability factors in body dysmorphic disorder. (23890696)
2013
3
Altered spontaneous activity in antisocial personality disorder revealed by regional homogeneity. (23804035)
2013
4
Biobehavioral reactivity to social evaluative stress in women with borderline personality disorder. (23244772)
2013
5
Paranoid personality disorder and the schizophrenia spectrum-Where to draw the line? (24343968)
2013
6
Similar benefits with dialectical behaviour therapy or general psychiatric management for people with borderline personality disorder. (23161563)
2013
7
Predicting borderline personality disorder features from personality traits, identity orientation, and attachment styles in Italian nonclinical adults: issues of consistency across age ranges. (22486456)
2012
8
Exploring Registered Psychiatric Nurses' Responses towards Service Users with a Diagnosis of Borderline Personality Disorder. (22577537)
2012
9
Children of mothers with borderline personality disorder: identifying parenting behaviors as potential targets for intervention. (22299065)
2012
10
The interactive role of distress tolerance and borderline personality disorder in suicide attempts among substance users in residential treatment. (22595187)
2012
11
Frequency of Borderline Personality Disorder Among Psychiatric Outpatients in Shanghai. (22494175)
2012
12
Association between the Rorschach Ego Impairment Index and the Level of Personality Organization interview assessment in depressive and anxiety disorder patients. (22633010)
2012
13
Dysfunctional affect regulation in borderline personality disorder and in somatoform disorder. (22984638)
2012
14
Memory specificity in borderline personality disorder: associations with depression and self-discrepancy. (23200432)
2012
15
Dependent personality disorder and physical abuse. (20537714)
2011
16
Is there any influence of personality disorder on the short term intensive group cognitive behavioral therapy of social phobia? (21475384)
2011
17
Tryptophan-hydroxylase 2 haplotype association with borderline personality disorder and aggression in a sample of patients with personality disorders and healthy controls. (20451217)
2010
18
A treatment guideline for people with antisocial personality disorder: overcoming attitudinal barriers and evidential limitations. (19343700)
2009
19
Cognitive behaviour therapy for violent men with antisocial personality disorder in the community: an exploratory randomized controlled trial. (18667099)
2009
20
Treatment with aripiprazole and topiramate in an obese subject with borderline personality disorder, obsessive-compulsive symptoms and bulimia nervosa: a case report. (19829941)
2009
21
Impact of borderline personality disorder on bulimia nervosa. (19016090)
2008
22
Smaller neocortical gray matter and larger sulcal cerebrospinal fluid volumes in neuroleptic-naive women with schizotypal personality disorder. (17015811)
2006
23
Is antisocial personality disorder continuous or categorical? A taxometric analysis. (16836795)
2006
24
The dimensionality of dependent personality disorder. (15615670)
2004
25
Trichotillomania: response to lithium in a person with comorbid bipolar disorder. (14533143)
2003
26
Polymorphism in exon 6 of the dopamine D(2) receptor gene (DRD2) is associated with elevated blood pressure and personality disorders in men. (11494094)
2001
27
Sensory gating deficits assessed by the P50 event-related potential in subjects with schizotypal personality disorder. (10618013)
2000
28
Substance abuse patterns and their association with psychopathology and type of hostility in male patients with borderline and antisocial personality disorder. (10428187)
1999
29
Antisocial personality disorder, psychopathy and injecting heroin use. (9788008)
1998
30
Antisocial personality disorder and psychopathy: diagnostic dilemmas in classifying patterns of antisocial behavior in sentencing evaluations. (9768465)
1998
31
An ethical framework for understanding patients with antisocial personality disorder who develop dementia: diagnosing and managing disorders of autonomy. (11656997)
1997
32
Assessing the criminal responsibility of individuals with multiple personality disorder: legal cases, legal theory. (9323664)
1997
33
CSF 5-HIAA and family history of antisocial personality disorder in newborns. (9396964)
1997
34
Death rates in 71 men with antisocial personality disorder. A comparison with general population mortality. (8742541)
1996
35
Child abuse and multiple personality disorder. (8185019)
1994
36
Personality and disinhibitory psychopathology: alcoholism and antisocial personality disorder. (8040486)
1994
37
Antisocial personality disorder in abused and neglected children grown up. (8166307)
1994
38
Comparison of personality disorders in different anxiety disorder diagnoses: panic, agoraphobia, generalized anxiety, and social phobia. (7804388)
1994
39
Child abuse and multiple personality disorder. (8185018)
1994
40
Reduced P300 amplitude in relation to family history of alcoholism and antisocial personality disorder among young men at risk for alcoholism. (7748355)
1993
41
Antisocial personality disorder among drug abusers. Relations to other personality diagnoses and the five-factor model of personality. (8501448)
1993
42
Antisocial personality disorder. (8373756)
1993
43
Avoidant personality disorder and the generalized subtype of social phobia. (1583226)
1992
44
Object relations, defensive operations, and affective states in narcissistic, borderline, and antisocial personality disorder. (1512679)
1992
45
The relationship of social phobia subtypes and avoidant personality disorder. (1778076)
1991
46
The antisocial personality disorder diagnosis. (2386266)
1990
47
Multiple personality disorder. (2611585)
1989
48
The narcissistic personality disorder and the differential diagnosis of antisocial behavior. (2678022)
1989
49
Narcissistic personality disorder. A validity study and comparison to borderline personality disorder. (2798199)
1989
50
Techniques in the treatment of multiple personality disorder. (3354722)
1988

Genetic Variations for Personality Disorder

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Expression for genes affiliated with Personality Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Personality Disorder

Search GEO for disease gene expression data for Personality Disorder.

Pathways for genes affiliated with Personality Disorder

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 49PharmGKB, 12EMD Millipore
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Pathways related to Personality Disorder according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4SLC6A3, MAOA
2
Hide members
10.4MAOA, MAOB
3
Hide members
10.3TPH1, TPH2
4
Hide members
10.3TPH1, TPH2
5
Hide members
10.3TPH2, TPH1
610.3SLC6A3, SLC6A4, TPH2
7
Hide members
10.3MAOA, TPH1, TPH2
8
Hide members
10.3COMT, MAOA, MAOB
9
Hide members
10.3COMT, MAOA, MAOB
10
Tyrosine metabolism p.1 (dopamine)
Hide members
10.3MAOB, MAOA, COMT
1110.3DRD2, DRD3, DRD4
12
Hide members
10.3DRD2, DRD3, DRD4
1310.2SLC6A3, MAOB, MAOA, DRD2
14
Hide members
10.2DRD2, MAOA, MAOB, SLC6A3
15
Hide members
10.2MAOA, MAOB, TPH1, TPH2
1610.2HTR2A, MAOA, SLC6A4, TPH1, TPH2
1710.2DRD4, DRD3, HTR2A, RXFP3
18
Hide members
10.1SLC6A4, HTR1B, HTR2A, DRD2, DRD3, DRD4
19
Hide members
10.0RXFP3, HTR1B, HTR2A, DRD2, DRD3, DRD4
20
Hide members
9.9RXFP3, HTR1B, HTR2A, DRD2, DRD3, DRD4
21
Hide members
9.9COMT, HTR1B, HTR2A, DRD2, DRD3, DRD4

Compounds for genes affiliated with Personality Disorder

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Personality Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 306)
idCompoundScoreTop Affiliating Genes
1mdma4410.5TPH1, MAOB, SLC6A3, SLC6A4, PRL, MAOA
2pergolide28 44 1112.5PRL, COMT, HTR1B, HTR2A, DRD2, DRD3
3methylphenidate44 49 1112.5COMT, DRD2, DRD4, MAOA, MAOB, SLC6A3
4mhpg4410.5SLC6A4, DRD4, MAOA, PRL, MAOB, COMT
5bromocriptine28 44 1112.5COMT, HTR1B, HTR2A, DRD3, DRD4, PRL
6cabergoline28 44 1112.5PRL, DRD4, COMT, HTR1B, HTR2A, DRD2
7MMDA1110.5HTR2A, SLC6A4, SLC6A3, MAOB, MAOA
8terguride28 4411.5HTR1B, DRD4, DRD3, PRL, DRD2, HTR2A
9fenfluramine28 44 1112.5TPH1, SLC6A4, PRL, HTR2A, HTR1B, TPH2
10ropinirole44 1111.5COMT, HTR1B, HTR2A, DRD2, DRD3, DRD4
11nemonapride49 44 2812.5DRD3, ANKK1, DRD4, PRL, DRD2
12homovanillic acid44 2411.5SLC6A4, PRL, COMT, TPH1, MAOA, MAOB
13lisuride28 44 1112.5HTR2A, DRD2, DRD3, DRD4, HTR1B, PRL
14d amphetamine4410.4SLC6A4, SLC6A3, MAOB, MAOA, DRD2
15remoxipride44 1111.4DRD3, DRD2, DRD4, PRL, HTR2A
16heroin44 49 1112.4COMT, DRD2, DRD3, DRD4, SLC6A3, SLC6A4
17bupropion44 49 11 2413.4ANKK1, DRD3, DRD2, COMT, SLC6A3, MAOB
18citalopram49 44 11 2413.4MAOB, MAOA, PRL, SLC6A3, SLC6A4, TPH1
19quetiapine44 49 28 11 2414.4HTR2A, DRD2, DRD3, DRD4, PRL, HTR1B
20pramipexole44 49 28 1113.4SLC6A3, PRL, COMT, HTR1B, HTR2A, DRD2
21raclopride44 2811.4HTR2A, DRD2, DRD3, DRD4, SLC6A3
22amphetamine44 1111.4DRD2, DRD4, MAOA, MAOB, SLC6A3, SLC6A4
23mptp4410.4SLC6A4, MAOB, MAOA, DRD2, COMT, DRD3
246-hydroxydopamine4410.4DRD3, SLC6A3, MAOA, DRD2, COMT, DRD4
25aripiprazole28 49 44 11 2414.4HTR2A, PRL, DRD4, DRD3, HTR1B, DRD2
26methamphetamine44 49 1112.4TPH1, SLC6A4, COMT, DRD2, DRD3, DRD4
27carbidopa44 2811.4TPH1, SLC6A3, MAOB, PRL, COMT
28apomorphine44 28 1112.4COMT, HTR1B, HTR2A, DRD2, DRD3, DRD4
29roxindole28 4411.3HTR1B, HTR2A, DRD2, DRD3, DRD4
30ziprasidone49 28 44 1113.3HTR1B, HTR2A, DRD2, DRD4, PRL, DRD3
31haloperidol44 28 2 49 1114.3SLC6A4, HTR2A, SLC6A3, MAOB, DRD2, DRD3
32paroxetine44 49 28 1113.3COMT, HTR1B, HTR2A, DRD3, DRD4, PRL
33olanzapine49 44 28 11 2414.3COMT, HTR1B, HTR2A, DRD2, DRD3, DRD4
34cocaine44 1111.3COMT, HTR1B, SLC6A4, DRD2, DRD3, DRD4
35fluoxetine49 44 28 1113.3HTR1B, HTR2A, SLC6A4, TPH1, TPH2, SLC6A3
36clozapine44 28 49 1113.3SLC6A4, HTR2A, DRD2, DRD3, DRD4, PRL
37piperazine44 1111.3DRD2, SLC6A3, HTR2A, DRD4, DRD3
38risperidone28 44 49 59 11 2415.3COMT, HTR1B, HTR2A, DRD2, DRD3, DRD4
39levodopa44 1111.3MAOA, PRL, DRD4, DRD3, DRD2, HTR1B
40maoa4410.3COMT, HTR1B, HTR2A, DRD2, DRD4, MAOA
41amisulpride44 28 1112.2HTR2A, DRD2, PRL, DRD3
42sulpiride44 28 1112.2DRD3, DRD4, PRL, SLC6A3, DRD2
43amine4410.2COMT, SLC6A4, TPH1, DRD3, MAOA, MAOB
44nicotine44 49 28 1113.2TPH1, SLC6A4, TTF2, MAOB, DRD2, SLC6A3
45trimipramine49 44 1112.2PRL, SLC6A4, DRD2, SLC6A3, HTR2A
465-hydroxytryptamine4410.2COMT, TPH1, HTR1B, HTR2A, DRD2, DRD4
47norepinephrine44 11 2412.1DRD3, DRD4, PRL, MAOA, MAOB, SLC6A3
48dopamine44 28 11 2413.1DRD2, HTR2A, HTR1B, COMT, TPH1, SLC6A4
49epinephrine44 11 2411.9COMT, MAOA, MAOB, DRD4, DRD2, LBR
50paliperidone44 1110.8PRL, DRD2, HTR2A, DRD3, DRD4

GO Terms for genes affiliated with Personality Disorder

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Sources:
16Gene Ontology
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Cellular components related to Personality Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058869.8RXFP3, HTR1B, HTR2A, DRD2, DRD3, DRD4
2integral to plasma membraneGO:0058879.7SLC6A4, RXFP3, HTR1B, HTR2A, DRD2, DRD3

Biological processes related to Personality Disorder according to GeneCards/GeneDecks:

(show all 46)
idNameGO IDScoreTop Affiliating Genes
1dopamine catabolic processGO:04242010.7SLC6A3, MAOA, COMT
2negative regulation of synaptic transmission, glutamatergicGO:05196710.7DRD2, HTR2A, HTR1B
3negative regulation of voltage-gated calcium channel activityGO:190138610.7DRD2, DRD4
4neurotransmitter biosynthetic processGO:04213610.7SLC6A3, MAOA, COMT
5response to histamineGO:03477610.7DRD4, DRD3, DRD2
6negative regulation of dopamine receptor signaling pathwayGO:06016010.7DRD2, DRD3
7positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.7DRD2, DRD4
8serotonin biosynthetic processGO:04242710.7TPH1, TPH2
9G-protein coupled receptor internalizationGO:00203110.7HTR1B, DRD3, DRD2
10dopamine metabolic processGO:04241710.7DRD2, DRD3, DRD4
11aromatic amino acid family metabolic processGO:00907210.7TPH2, TPH1
12negative regulation of protein secretionGO:05070910.7DRD2, DRD3, DRD4
13prepulse inhibitionGO:06013410.7SLC6A3, DRD3, DRD2
14behavioral response to cocaineGO:04814810.7DRD2, DRD3, DRD4
15negative regulation of serotonin secretionGO:01406310.7MAOB, HTR1B
16synaptic transmission, dopaminergicGO:00196310.7DRD4, DRD3, DRD2
17regulation of dopamine uptake involved in synaptic transmissionGO:05158410.7DRD3, DRD2
18arachidonic acid secretionGO:05048210.7DRD2, DRD3, DRD4
19regulation of dopamine secretionGO:01405910.7HTR1B, HTR2A, DRD2, DRD3
20response to cocaineGO:04222010.7HTR1B, DRD2, DRD3, SLC6A3
21monoamine transportGO:01584410.7SLC6A4, SLC6A3
22indolalkylamine biosynthetic processGO:04621910.7TPH1, TPH2
23negative regulation of adenylate cyclase activityGO:00719410.7DRD2, DRD3, DRD4
24social behaviorGO:03517610.7DRD3, DRD4, SLC6A4
25neurotransmitter catabolic processGO:04213510.7COMT, MAOA
26response to amphetamineGO:00197510.7DRD4, DRD3, DRD2
27circadian rhythmGO:00762310.6PRL, SLC6A4, TPH1, TPH2
28regulation of cAMP metabolic processGO:03081410.6DRD2, DRD3
29adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.6FLNA, DRD4, DRD3, DRD2
30adenohypophysis developmentGO:02198410.6DRD2, SLC6A3
31cellular calcium ion homeostasisGO:00687410.6DRD4, DRD3, DRD2, HTR2A
32behavioral response to ethanolGO:04814910.6DRD2, DRD4
33response to ethanolGO:04547110.6HTR1B, DRD3, PRL, MAOB, SLC6A3
34regulation of dopamine metabolic processGO:04205310.6DRD4, SLC6A3
35response to toxic substanceGO:00963610.5SLC6A4, MAOB, DRD2
36synaptic transmissionGO:00726810.5COMT, HTR1B, HTR2A, MAOA, SLC6A3
37negative regulation of cAMP biosynthetic processGO:03081810.5DRD4, HTR1B
38locomotory behaviorGO:00762610.5SLC6A3, DRD3, DRD2
39regulation of behaviorGO:05079510.5HTR1B, HTR2A
40response to iron ionGO:01003910.4DRD2, SLC6A3
41response to drugGO:04249310.4COMT, HTR2A, DRD2, DRD3, PRL, MAOB
42circadian regulation of gene expressionGO:03292210.3DRD2, DRD3
43elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148210.3DRD2, RXFP3
44bone remodelingGO:04684910.3HTR1B, TPH1
45small molecule metabolic processGO:04428110.2COMT, LBR, MAOA, MAOB, CLPS, TPH1
46positive regulation of renal sodium excretionGO:03581510.0DRD2, DRD3

Molecular functions related to Personality Disorder according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1serotonin bindingGO:05137810.4HTR2A, HTR1B
2tryptophan 5-monooxygenase activityGO:00451010.3TPH2, TPH1
3dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.3DRD2, DRD3, DRD4
4dopamine bindingGO:03524010.3SLC6A3, DRD4, DRD3, DRD2
5monoamine transmembrane transporter activityGO:00850410.3SLC6A4, SLC6A3
6drug bindingGO:00814410.3SLC6A3, HTR1B, HTR2A, DRD2, DRD3, DRD4
7primary amine oxidase activityGO:00813110.1MAOB, MAOA

Products for genes affiliated with Personality Disorder

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Sources for Personality Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet