MCID: PRS038
MIFTS: 50

Personality Disorder malady

Mental diseases category

Summaries for Personality Disorder

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MedlinePlus:32 Personality disorders are a group of mental illnesses. they involve long-term patterns of thoughts and behaviors that are unhealthy and inflexible. the behaviors cause serious problems with relationships and work. people with personality disorders have trouble dealing with everyday stresses and problems. they often have stormy relationships with other people. the cause of personality disorders is unknown. however, genes and childhood experiences may play a role. the symptoms of each personality disorder are different. they can mild or severe. people with personality disorders may have trouble realizing that they have a problem. to them, their thoughts are normal, and they often blame others for their problems. they may try to get help because of their problems with relationships and work. treatment usually includes talk therapy and sometimes medicine.

MalaCards based summary: Personality Disorder, also known as personality disorders, is related to obsessive-compulsive personality disorder and borderline personality disorder. An important gene associated with Personality Disorder is TTF2 (transcription termination factor, RNA polymerase II), and among its related pathways are Dopamine metabolism and Serotonin clearance from the synaptic cleft. The compounds mhpg and minaprine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related mouse phenotypes are endocrine/exocrine gland and muscle.

Disease Ontology:9 A disease of mental health that involve long-term patterns of thoughts and behaviors that cause serious problems with relationships and work.

Wikipedia:63 Personality disorders are a class of mental disorders characterized by enduring maladaptive patterns of... more...

Aliases & Classifications for Personality Disorder

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Personality Disorder, Aliases & Descriptions:

Name: Personality Disorder 9
Personality Disorders 43 32 60
 
Character Disorder 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology9 DOID:1510
ICD9CM27 301.8, 301.89
ICD1025 F60, F60.9

Related Diseases for Personality Disorder

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Diseases in the Personality Disorder family:

Multiple Personality Disorder

Diseases related to Personality Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 120)
idRelated DiseaseScoreTop Affiliating Genes
1obsessive-compulsive personality disorder31.5CLPS, SLC6A4
2borderline personality disorder31.5SLC6A4, CLPS, MAOA, HTR1B, TTF2
3schizophrenia31.3HTR2A, COMT
4anxiety disorder31.2MAOA, SLC6A4
5social phobia31.1COMT, MAOA, SLC6A4
6substance abuse31.0SLC6A3, SLC6A4
7intermittent explosive disorder31.0HTR1B
8bipolar disorder31.0HTR2A, SLC6A4
9pathological gambling30.8SLC6A3
10antisocial personality disorder30.7SLC6A3, SLC6A4, MAOA, HTR1B, HTR2A, TTF2
11substance dependence30.7COMT, SLC6A4, SLC6A3
12dysthymic disorder30.7MAOA, HTR2A
13cocaine dependence30.6SLC6A3, SLC6A4
14paranoid schizophrenia30.6COMT
15chronic fatigue syndrome30.5SLC6A4, MAOA
16melancholia30.5MAOA
17alcohol dependence30.3HTR1B, HTR2A, SLC6A4, MAOA
18oppositional defiant disorder30.3SLC6A3
19anorexia nervosa30.2SLC6A4, MAOA, COMT, HTR2A
20conduct disorder30.2TTF2, COMT, MAOA, SLC6A3, SLC6A4
21drug dependence30.2SLC6A4, MAOA, SLC6A3
22eating disorder30.2HTR2A, COMT, SLC6A4, SLC6A3
23cocaine abuse30.1SLC6A4, SLC6A3
24generalized anxiety disorder30.1HTR2A, SLC6A4, MAOA
25bulimia nervosa30.1HTR2A, COMT, MAOA, SLC6A4, HTR1B
26panic disorder30.0HTR2A, TTF2, COMT, SLC6A4, MAOA
27alcohol abuse30.0SLC6A4, COMT, SLC6A3
28asthma29.9TTF2, HTR2A
29obsessive-compulsive disorder29.5SLC6A3, SLC6A4, MAOA, COMT, HTR1B, HTR2A
30dementia29.4MAOA, HTR2A, TTF2, SLC6A3, COMT
31mood disorder29.3SLC6A4, HTR2A, HTR1B, COMT, SLC6A3, MAOA
32attention deficit-hyperactivity disorder29.3TTF2, HTR2A, HTR1B, SLC6A3, SLC6A4, MAOA
33obesity29.2CLPS, SLC6A3, HTR2A, COMT, MAOA, TTF2
34psychotic disorder29.0SLC6A3, MAOA, COMT, TTF2, HTR2A, SLC6A4
35migraine28.9HTR1B, HTR2A, COMT, MAOA, SLC6A3, SLC6A4
36multiple personality disorder11.1
37schizotypal personality disorder11.0
38narcissistic personality disorder10.9
39avoidant personality disorder10.9
40dependent personality disorder10.6
41histrionic personality disorder10.6
42paranoid personality disorder10.6
43schizoid personality disorder10.6
44alexithymia10.5
45alcoholic psychosis10.5SLC6A4
46premature ejaculation10.5SLC6A4
47agoraphobia10.4
48heroin dependence10.3
49nicotine dependence, protection against10.3SLC6A4
50somatization disorder10.3

Graphical network of the top 20 diseases related to Personality Disorder:



Diseases related to personality disorder

Symptoms for Personality Disorder

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Drugs & Therapeutics for Personality Disorder

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Drug clinical trials:

Search ClinicalTrials for Personality Disorder

Search NIH Clinical Center for Personality Disorder

Genetic Tests for Personality Disorder

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Anatomical Context for Personality Disorder

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MalaCards organs/tissues related to Personality Disorder:

31
Brain, Testes, Eye, Amygdala, Temporal lobe, Bone, Caudate nucleus, Cortex, Pituitary, Heart, Prefrontal cortex, Thyroid, Breast, Ovary, Endothelial, Thalamus

Animal Models for Personality Disorder or affiliated genes

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MGI Mouse Phenotypes related to Personality Disorder:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.1SLC6A3, SLC6A4, HTR1B, HTR2A
2MP:00053697.8HTR2A, HTR1B, SLC6A4, SLC6A3
3MP:00053866.6SLC6A3, SLC6A4, MAOA, COMT, HTR1B, HTR2A

Publications for Personality Disorder

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Articles related to Personality Disorder:

(show top 50)    (show all 1841)
idTitleAuthorsYear
1
Beyond the diagnostic traits: A collaborative exploratory diagnostic process for dimensions and underpinnings of narcissistic personality disorder. (25314232)
2014
2
Stability of narcissistic personality disorder: tracking categorical and dimensional rating systems over a two-year period. (24512458)
2014
3
'It's One of the Hardest Jobs in the World': The Experience and Understanding of Qualified Nurses Who Work with Individuals Diagnosed with Both Learning Disability and Personality Disorder. (25196279)
2014
4
Changes in low-frequency fluctuations in patients with antisocial personality disorder revealed by resting-state functional MRI. (24598769)
2014
5
Doing Psychiatry Right: A Case of Severe Avoidant Personality Disorder with Obsessive-compulsive Personality Disorder, Obsessive Compulsive Disorder, Intermittent Explosive Disorder and Sexual Paraphilias. (25035563)
2014
6
Emotional cascades as prospective predictors of dysregulated behaviors in borderline personality disorder. (23046043)
2013
7
Distinguishing bipolar II depression from major depressive disorder with comorbid borderline personality disorder: demographic, clinical, and family history differences. (24107761)
2013
8
A developing world perspective on homicide and personality disorder. (24166685)
2013
9
Medial prefrontal dysfunction and prolonged amygdala response during instructed fear processing in borderline personality disorder. (22404662)
2013
10
Schizotypal personality disorder. (22928856)
2013
11
A Further Validation of the Minnesota Borderline Personality Disorder Scale. (24364505)
2013
12
Comorbidity of social anxiety disorder and antisocial personality disorder in the National Epidemiological Survey on Alcohol and Related Conditions (NESARC). (24384071)
2013
13
A Case of Depressive Personality Disorder: Aligning Theory, Practice, and Clinical Research. (23957236)
2013
14
Getting the word out about treating borderline personality disorder: an online information resource. (23334680)
2013
15
Alexithymia as a mediator between attachment and the development of borderline personality disorder in adolescence. (23013337)
2012
16
The association of 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR gene polymorphisms and antisocial personality disorder in male heroin-dependent Chinese subjects. (22138326)
2012
17
Management of borderline personality disorder. (23027916)
2012
18
Avoidant personality disorder in individuals with generalized social anxiety disorder: what does it add? (22705954)
2012
19
Platelet protein kinase C and brain-derived neurotrophic factor levels in borderline personality disorder patients. (22633012)
2012
20
Diagnosis of antisocial personality disorder and criminal responsibility. (21903271)
2011
21
Antisocial personality disorder is on a continuum with psychopathy. (20579518)
2010
22
Diagnosis and subtypes of adolescent antisocial personality disorder. (20420477)
2010
23
Incremental effect for antisocial personality disorder genetic risk combining 5-HTTLPR and 5-HTTVNTR polymorphisms. (20363030)
2010
24
Factor structure and diagnostic efficiency of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria for avoidant personality disorder in Hispanic men and women with substance use disorders. (19683617)
2009
25
5-HT1A receptor gene C -1019 G polymorphism and amygdala volume in borderline personality disorder. (18387137)
2008
26
Clozapine in treatment-refractory obsessive-compulsive disorder with comorbid schizotypal personality disorder. (19398826)
2008
27
A time series evaluation of the treatment of histrionic personality disorder with cognitive analytic therapy. (17877864)
2007
28
Similar or disparate brain patterns? The intra-personal EEG variability of three women with multiple personality disorder. (16929711)
2006
29
Etiology of antisocial personality disorder: benefits for society from an evolutionary standpoint. (16006050)
2005
30
Borderline personality disorder, antisocial personality disorder and risk-taking among heroin users: findings from the Australian Treatment Outcome Study (ATOS). (15072810)
2004
31
The role of personality disorders on drug dependence treatment outcomes following inpatient detoxification. (15196598)
2004
32
Misdiagnosis of Asperger syndrome as anankastic personality disorder. (12540134)
2002
33
Neuropsychological performance in schizotypal personality disorder: evidence regarding diagnostic specificity. (12488063)
2002
34
Diagnosing antisocial personality disorder among substance abusers: the scid versus the MCMI-II. (11727884)
2001
35
Schizotypal personality disorder and MRI abnormalities of temporal lobe gray matter. (10356620)
1999
36
Gender differences in the relationship of antisocial personality disorder criteria to Psychopathy Checklist-Revised scores. (9573521)
1998
37
Acute and transient psychotic disorder: comorbidity with personality disorder. (9021000)
1996
38
Death rates in 71 men with antisocial personality disorder. A comparison with general population mortality. (8742541)
1996
39
m-Chlorophenylpiperazine challenge in borderline personality disorder: relationship of neuroendocrine response, behavioral response, and clinical measures. (8879471)
1996
40
Schizoid personality disorder after prenatal exposure to famine. (8942466)
1996
41
Re: Psychiatrists' attitudes to multiple personality disorder. (8681274)
1995
42
Antisocial personality disorder as a prognostic factor for pharmacotherapy of cocaine dependence. (8082553)
1994
43
Child abuse and multiple personality disorder. (8185019)
1994
44
Drinking outcomes of alcohol abusers diagnosed as antisocial personality disorder. (7978086)
1994
45
Multiple personality disorder and satanic ritual abuse. (8135697)
1993
46
Expressive therapy in conjunction with psychotherapy in the treatment of persons with multiple personality disorder. (2252072)
1990
47
Multiple personality disorder. (2611585)
1989
48
Autohypnotic resolution of an incipient relapse in an integrated multiple personality disorder patient: a clinical note. (3228064)
1988
49
The relationship of histrionic personality disorder to antisocial personality and somatization disorders. (3717392)
1986
50
Clinical phobias and avoidant personality disorder among alcoholics admitted to an alcoholism rehabilitation setting. (3791123)
1986

Variations for Personality Disorder

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Expression for genes affiliated with Personality Disorder

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Search GEO for disease gene expression data for Personality Disorder.

Pathways for genes affiliated with Personality Disorder

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Pathways related to Personality Disorder according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6COMT, MAOA
2
Show member pathways
9.6COMT, MAOA
3
Show member pathways
catecholamine biosynthesis36
9.6MAOA, COMT
4
Show member pathways
phenylalanine utilization36
noradrenaline and adrenaline degradation36
phenylalanine degradation IV36
9.6MAOA, COMT
59.6MAOA, COMT
69.6MAOA, COMT
7
Show member pathways
9.3HTR1B, HTR2A
8
Show member pathways
9.3SLC6A3, MAOA
99.1SLC6A4, MAOA, HTR2A
10
Show member pathways
Serotonin Transporter Activity36
8.9SLC6A3, SLC6A4, MAOA
11
Show member pathways
8.8COMT, MAOA, SLC6A3
128.5HTR2A, HTR1B, MAOA, SLC6A4
13
Show member pathways
7.3SLC6A3, SLC6A4, MAOA, COMT, HTR1B, HTR2A

Compounds for genes affiliated with Personality Disorder

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Compounds related to Personality Disorder according to GeneCards Suite gene sharing:

(show top 50)    (show all 172)
idCompoundScoreTop Affiliating Genes
1mhpg439.4MAOA, COMT, SLC6A4
2minaprine43 1210.4SLC6A4, HTR2A, MAOA
3naratriptan43 28 1211.3HTR2A, HTR1B, MAOA
4mcpp439.2HTR2A, HTR1B, SLC6A4
5carbon-11439.2SLC6A3, SLC6A4, MAOA
6p-chloroamphetamine439.2SLC6A3, MAOA, SLC6A4
7phentermine43 1210.2SLC6A3, MAOA, SLC6A4
8d amphetamine439.2SLC6A4, SLC6A3, MAOA
9pindolol43 28 1211.2HTR2A, HTR1B, SLC6A4
10pseudoephedrine43 24 1211.2SLC6A3, SLC6A4, MAOA
11mdma439.1MAOA, SLC6A4, SLC6A3
12maprotiline43 49 1211.1SLC6A4, SLC6A3, MAOA
13methysergide43 28 1211.1HTR2A, HTR1B, MAOA
14tryptamine43 28 2411.0HTR2A, HTR1B, MAOA
15Serotonin249.0HTR1B, HTR2A, SLC6A4, MAOA
16amine438.9COMT, HTR1B, SLC6A4, MAOA
17duloxetine43 49 28 1211.9HTR2A, SLC6A4, SLC6A3
18fenfluramine43 28 1210.9HTR2A, SLC6A4, HTR1B
19ropinirole43 129.9COMT, HTR2A, HTR1B
20methylphenidate43 49 1210.8SLC6A4, MAOA, SLC6A3, COMT
21tyramine43 28 2410.8SLC6A4, MAOA, COMT, SLC6A3
22methamphetamine43 49 1210.8SLC6A3, COMT, SLC6A4, MAOA
23mianserin43 28 1210.8HTR2A, MAOA, SLC6A4
24trimipramine43 49 1210.8SLC6A4, SLC6A3, HTR2A
25mptp438.8SLC6A4, COMT, MAOA, SLC6A3
26amitriptyline43 28 49 1211.6SLC6A4, HTR2A, MAOA, SLC6A3
27desipramine43 49 1210.6HTR2A, MAOA, SLC6A4, SLC6A3
28citalopram43 49 24 1211.6MAOA, SLC6A4, SLC6A3, HTR2A
29imipramine43 28 49 24 1212.6SLC6A3, SLC6A4, MAOA, HTR2A
30levodopa43 129.5HTR1B, COMT, MAOA, SLC6A3
31nefazodone43 49 1210.5SLC6A4, SLC6A3, HTR1B, HTR2A
32escitalopram43 49 24 1211.5SLC6A4, HTR2A, SLC6A3
33quetiapine43 49 28 24 1212.5HTR2A, HTR1B, SLC6A4, SLC6A3
34pramipexole43 28 49 1211.5COMT, SLC6A3, HTR1B, HTR2A
35carbon438.5COMT, TTF2, SLC6A4, SLC6A3, MAOA
36nicotine43 28 49 1211.5MAOA, TTF2, COMT, SLC6A4, SLC6A3
37apomorphine28 43 1210.5HTR2A, HTR1B, COMT, SLC6A3
38bromocriptine43 28 1210.4SLC6A3, COMT, HTR1B, HTR2A
39fluvoxamine43 49 1210.2MAOA, COMT, HTR2A, SLC6A4, SLC6A3
40clomipramine43 49 1210.2SLC6A3, SLC6A4, MAOA, HTR1B, HTR2A
41fluoxetine43 49 28 1211.2SLC6A3, SLC6A4, HTR1B, MAOA, HTR2A
42venlafaxine43 49 24 1211.1SLC6A3, HTR2A, HTR1B, COMT, SLC6A4
43risperidone43 49 28 59 24 1213.1SLC6A3, SLC6A4, COMT, HTR1B, HTR2A
44olanzapine43 49 28 24 1212.1HTR2A, SLC6A3, SLC6A4, COMT, HTR1B
45norepinephrine43 24 1210.1HTR2A, COMT, SLC6A4, SLC6A3, MAOA
46clozapine43 28 49 1211.1COMT, HTR1B, SLC6A4, SLC6A3, HTR2A
47maoa437.7SLC6A4, HTR2A, HTR1B, COMT, MAOA, SLC6A3
48paroxetine43 49 28 1210.7HTR2A, SLC6A3, HTR1B, COMT, MAOA, SLC6A4
495-hydroxytryptamine437.7HTR2A, HTR1B, SLC6A3, SLC6A4, COMT, MAOA
50dopamine43 28 24 1210.7SLC6A4, MAOA, SLC6A3, HTR2A, COMT, HTR1B

GO Terms for genes affiliated with Personality Disorder

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Cellular components related to Personality Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058878.1SLC6A3, SLC6A4, HTR1B, HTR2A

Biological processes related to Personality Disorder according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1neurotransmitter catabolic processGO:00421359.8MAOA, COMT
2vasoconstrictionGO:00423109.4SLC6A4, HTR1B
3regulation of dopamine secretionGO:00140599.4HTR1B, HTR2A
4memoryGO:00076139.4SLC6A4, HTR2A
5monoamine transportGO:00158449.4SLC6A4, SLC6A3
6negative regulation of synaptic transmission, glutamatergicGO:00519679.4HTR1B, HTR2A
7regulation of behaviorGO:00507959.3HTR2A, HTR1B
8dopamine catabolic processGO:00424209.1SLC6A3, MAOA, COMT
9neurotransmitter biosynthetic processGO:00421369.1SLC6A3, MAOA, COMT
10response to cocaineGO:00422208.8SLC6A3, HTR1B
11response to drugGO:00424938.4SLC6A3, SLC6A4, COMT, HTR2A
12synaptic transmissionGO:00072687.9HTR2A, HTR1B, COMT, MAOA, SLC6A3

Molecular functions related to Personality Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serotonin receptor activityGO:00049939.3HTR1B, HTR2A
2monoamine transmembrane transporter activityGO:00085049.1SLC6A3, SLC6A4
3serotonin bindingGO:00513789.0HTR1B, HTR2A
4drug bindingGO:00081448.5SLC6A3, HTR1B, HTR2A

Products for genes affiliated with Personality Disorder

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Sources for Personality Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet