MCID: PRS038
MIFTS: 64

Personality Disorder malady

Neuronal diseases category

Summaries for Personality Disorder

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Personality disorders are a group of mental illnesses. they involve long-term patterns of thoughts and behaviors that are unhealthy and inflexible. the behaviors cause serious problems with relationships and work. people with personality disorders have trouble dealing with everyday stresses and problems. they often have stormy relationships with other people. the cause of personality disorders is unknown. however, genes and childhood experiences may play a role. the symptoms of each personality disorder are different. they can mild or severe. people with personality disorders may have trouble realizing that they have a problem. to them, their thoughts are normal, and they often blame others for their problems. they may try to get help because of their problems with relationships and work. treatment usually includes talk therapy and sometimes medicine.

MalaCards: Personality Disorder, also known as personality disorders, is related to borderline personality disorder and antisocial personality disorder. An important gene associated with Personality Disorder is TTF2 (transcription termination factor, RNA polymerase II), and among its related pathways are Enzymatic degradation of dopamine by COMT and melatonin degradation II. The compounds mdma and pergolide have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related mouse phenotypes are adipose tissue and cardiovascular system.

Disease Ontology:8 A disease of mental health that involve long-term patterns of thoughts and behaviors that cause serious problems with relationships and work.

Wikipedia:63 Personality disorders are a class of mental disorders characterised by enduring maladaptive patterns of... more...

Aliases & Classifications for Personality Disorder

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8Disease Ontology, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

personality disorder 8
personality disorders 44 33 60
character disorder 8


External Ids:

Disease Ontology8 DOID:1510
ICD9CM27 301.8, 301.89
ICD1025 F60, F60.9

Related Diseases for Personality Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Personality Disorder family:

Multiple Personality Disorder

Diseases related to Personality Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 149)
idRelated DiseaseScoreTop Affiliating Genes
1borderline personality disorder31.8MAOA, CLPS, TTF2, SLC6A4, TPH1, FLNA
2antisocial personality disorder31.6TTF2, SLC6A3, SLC6A4, MAOA, ANKK1, HTR1B
3schizotypal personality disorder31.4COMT, LBR, FLNA
4dependent personality disorder31.2KNTC1
5obsessive-compulsive personality disorder31.1SLC6A4, CLPS
6obsessive-compulsive disorder31.0COMT, HTR1B, HTR2A, DRD2, DRD3, DRD4
7schizophrenia31.0COMT, HTR2A, DRD3
8social phobia30.9SLC6A4, MAOA, DRD2, COMT
9bipolar disorder30.8HTR2A, DRD2, SLC6A4
10substance dependence30.8COMT, DRD2, DRD3, DRD4, SLC6A3, SLC6A4
11anxiety disorder30.7TPH2, TPH1, SLC6A4, MAOA
12substance abuse30.7DRD2, DRD3, DRD4, SLC6A3, SLC6A4
13conduct disorder30.7COMT, DRD2, DRD4, MAOA, TTF2, SLC6A3
14eating disorder30.6COMT, HTR2A, SLC6A3, SLC6A4
15alexithymia30.6ANKK1
16cocaine dependence30.6DRD2, DRD3, SLC6A3, SLC6A4
17alcohol dependence30.6HTR1B, HTR2A, DRD2, DRD4, ANKK1, MAOA
18bulimia nervosa30.5COMT, HTR1B, HTR2A, MAOA, SLC6A4
19panic disorder30.5TPH1, TPH2, SLC6A4, TTF2, COMT, HTR2A
20attention deficit hyperactivity disorder30.5DRD4, SLC6A3
21mood disorder30.5COMT, HTR1B, HTR2A, DRD2, DRD3, DRD4
22heroin dependence30.4DRD2, DRD4, ANKK1
23pathological gambling30.4DRD2, DRD3, DRD4, SLC6A3
24anorexia nervosa30.4COMT, HTR2A, DRD4, PRL, MAOA, SLC6A4
25alcohol abuse30.3COMT, DRD2, DRD3, SLC6A3, SLC6A4
26paranoid schizophrenia30.3COMT
27generalized anxiety disorder30.3HTR2A, MAOA, SLC6A4, TPH1
28dysthymic disorder30.3HTR2A, MAOA
29drug dependence30.3DRD2, DRD3, MAOA, SLC6A3, SLC6A4
30obesity30.2COMT, HTR2A, DRD2, DRD4, MAOA, MAOB
31psychotic disorder30.2COMT, HTR2A, DRD2, DRD3, DRD4, PRL
32autistic disorder29.9SLC6A4, DRD4
33chronic fatigue syndrome29.9SLC6A4, MAOA, LBR
34cocaine abuse29.9SLC6A4, SLC6A3, DRD2
35seasonal affective disorder29.9HTR2A, DRD4, SLC6A4, TPH1
36nicotine dependence29.9DRD2, DRD4, ANKK1, SLC6A4
37dementia29.9COMT, HTR2A, MAOA, MAOB, TTF2, SLC6A3
38migraine29.9HTR1B, HTR2A, DRD2, DRD3, DRD4, MAOA
39alcoholic psychosis29.7SLC6A4
40melancholia29.7MAOA
41delusional disorder29.7DRD4, DRD2
42parkinson's disease29.7COMT, SLC6A3, MAOB, MAOA, DRD3, DRD2
43opiate dependence29.7DRD2, DRD3
44schizoaffective disorder29.7DRD2, DRD3, DRD4, PRL, SLC6A4, HTR2A
45alzheimer's disease29.7COMT, HTR2A, LBR, DRD2, DRD3, DRD4
46multiple personality disorder11.0
47narcissistic personality disorder10.8
48avoidant personality disorder10.8
49histrionic personality disorder10.6
50major depressive disorder10.5

Graphical network of the top 20 diseases related to Personality Disorder:



Diseases related to personality disorder

Clinical Features for Personality Disorder

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Drugs & Therapeutics for Personality Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Personality Disorder

Drug clinical trials:

Search ClinicalTrials for Personality Disorder

Search NIH Clinical Center for Personality Disorder

Search CenterWatch for Personality Disorder

Genetic Tests for Personality Disorder

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Anatomical Context for Personality Disorder

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32MalaCards
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MalaCards organs/tissues related to Personality Disorder:

32
Brain, Testes, Eye, Temporal lobe, Bone, Amygdala, Caudate nucleus, Cortex, Pituitary, Prefrontal cortex, Heart, Ovary, Breast, Thalamus, Thyroid, Endothelial

Animal Models for Personality Disorder or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Personality Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537510.1LBR, DRD2, DRD3, CLPS, TPH1, TPH2
2MP:000538510.0COMT, HTR1B, DRD2, DRD3, FLNA, MAOA
3MP:001077110.0LBR, DRD2, PRL, CLPS, SLC6A3, SLC6A4
4MP:000539010.0HTR2A, LBR, DRD2, FLNA, SLC6A3, TPH1
5MP:00036319.8COMT, LBR, DRD2, DRD3, DRD4, FLNA
6MP:00053799.7HTR1B, HTR2A, LBR, DRD2, PRL, SLC6A3
7MP:00053769.7FLNA, DRD4, DRD3, DRD2, LBR, COMT
8MP:00053789.7HTR1B, LBR, DRD2, DRD3, FLNA, CLPS
9MP:00053869.7TPH2, COMT, HTR1B, HTR2A, LBR, DRD2

Publications for Personality Disorder

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Sources:
50PubMed
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Articles related to Personality Disorder:

(show top 50)    (show all 1946)
idTitleAuthorsYear
1
Longitudinal transmission pathways of borderline personality disorder symptoms: from mother to child? (23713057)
2014
2
Psychosocial interventions for reducing vocal challenging behavior in persons with autistic disorder: a multilevel meta-analysis of single-case experiments. (24183495)
2013
3
Borderline personality disorder in adolescents: the He-who-must-not-be-named of psychiatry. (24174891)
2013
4
Clinical correlates of alexithymia among patients with personality disorder. (23731378)
2013
5
Polypharmacy and bipolar disorder: what's personality got to do with it? (24067291)
2013
6
Developmental trajectories of schizotypal personality disorder-like behavioural manifestations: a two-year longitudinal prospective study of college students. (24289659)
2013
7
Combined group and individual schema therapy for borderline personality disorder: A pilot study. (24342235)
2013
8
Relationships between individual differences in motivation and borderline personality disorder, psychopathy, and maladjustment. (24340807)
2013
9
Emotion differentiation as a protective factor against nonsuicidal self-injury in borderline personality disorder. (23768678)
2013
10
Facial emotion recognition in borderline personality disorder. (23149223)
2013
11
Eating disorder detection through personality traits and self-concept. (23221394)
2012
12
Stress Regulation and Incision in Borderline Personality Disorder-A Pilot Study Modeling Cutting Behavior. (22616773)
2012
13
Brain structure and function in borderline personality disorder. (22252376)
2012
14
Pregnancies, abortions, and births among women with and without borderline personality disorder. (22749198)
2012
15
Schizoid Personality Disorder. (22928849)
2012
16
Social cognition in borderline personality disorder: evidence for dichotomous thinking but no evidence for less complex attributions. (22982582)
2012
17
Early cannabis use and schizotypal personality disorder symptoms from adolescence to middle adulthood. (22325079)
2012
18
Affective disorders among patients with borderline personality disorder. (23236411)
2012
19
Differential relationships of impulsivity or antisocial symptoms on P50, N100, orA P200 auditory sensory gating in controls and antisocial personality disorder. (22464943)
2012
20
Diagnosis of antisocial personality disorder and criminal responsibility. (21903271)
2011
21
A (re)-evaluation of the symptom structure of borderline personality disorder. (21959028)
2011
22
Catch me if you can: do the five-factor model personality traits moderate dropout and acute treatment response in post-traumatic stress disorder patients? (21968691)
2011
23
Positive affective and cognitive states in borderline personality disorder. (22217230)
2011
24
Complex personality disorder in bulimia nervosa. (20965305)
2010
25
The integrity of corpus callosum and cluster B personality disorders: a quantitative MRI study in juvenile myoclonic epilepsy. (20156513)
2010
26
Factor structure and diagnostic efficiency of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria for avoidant personality disorder in Hispanic men and women with substance use disorders. (19683617)
2009
27
Qualitative and quantitative EEG abnormalities in violent offenders with antisocial personality disorder. (19134998)
2009
28
Extensive personal experience. Validation of prolactin levels in menstrual disorders and in prolactinomas. (20045798)
2009
29
Avoidant personality disorder and its relationship to social phobia. (19187715)
2009
30
The relationship between distress tolerance and antisocial personality disorder among male inner-city treatment seeking substance users. (18834298)
2008
31
The association of anxiety disorders and obsessive compulsive personality disorder with anorexia nervosa: evidence from a family study with discussion of nosological and neurodevelopmental implications. (17610248)
2007
32
Dual-task information processing in schizotypal personality disorder: evidence of impaired processing capacity. (16846263)
2006
33
The quality of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition dependent personality disorder prototype. (17067868)
2006
34
Catechol-O-methyltransferase Val158Met genotype variation is associated with prefrontal-dependent task performance in schizotypal personality disorder patients and comparison groups. (16691129)
2006
35
Fine mapping of the 5p13 locus linked to schizophrenia and schizotypal personality disorder in a Puerto Rican family. (16094256)
2005
36
Pathological gambling and personality disorders: an exploratory study with the IPDE. (15519959)
2004
37
A comparison of personality characteristics of patients with posttraumatic stress disorders and substance dependence: preliminary findings. (14504572)
2003
38
Polymorphisms of DRD4 and DRD3 and risk of avoidant and obsessive personality traits and disorders. (12860355)
2003
39
Hyperresponsiveness of hypothalamic-pituitary-adrenal axis to combined dexamethasone/corticotropin-releasing hormone challenge in female borderline personality disorder subjects with a history of sustained childhood abuse. (12460693)
2002
40
Alexithymia in patients with antisocial personality disorder in a military hospital setting. (11475919)
2001
41
Abnormal orienting in schizotypal personality disorder. (9050114)
1997
42
The morbidity of DSM-III-R dependent personality disorder. (8551285)
1996
43
Associations of beta-endorphin with HVA and MHPG in the plasma of prepubertal boys: effects of familial drug abuse and antisocial personality disorder liability. (8804130)
1996
44
Visual function in multiple personality disorder. (8888853)
1996
45
Multiple personality disorder. (7921709)
1994
46
Use of the MMPI to distinguish genuine from factitious multiple personality disorder. (8234591)
1993
47
A comparison of alternate systems for diagnosing antisocial personality disorder in cocaine abusers. (8320546)
1993
48
Cognitive and perceptual distortions in borderline personality disorder and schizotypal personality disorder in a vignette sample. (1591910)
1992
49
The Nottingham Study of Neurotic Disorder: relationship between personality status and symptoms. (2192383)
1990
50
HIV risk behavior: antisocial personality disorder, drug use patterns, and sexual behavior among methadone maintenance admissions. (2641008)
1989

Genetic Variations for Personality Disorder

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Expression for genes affiliated with Personality Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Personality Disorder

Search GEO for disease gene expression data for Personality Disorder.

Pathways for genes affiliated with Personality Disorder

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 49PharmGKB, 12EMD Millipore
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Pathways related to Personality Disorder according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4SLC6A3, MAOA
2
Hide members
10.4MAOA, MAOB
3
Hide members
10.3TPH1, TPH2
4
Hide members
10.3TPH1, TPH2
5
Hide members
10.3TPH2, TPH1
610.3SLC6A3, SLC6A4, TPH2
7
Hide members
10.3MAOA, TPH1, TPH2
8
Hide members
10.3COMT, MAOA, MAOB
9
Hide members
10.3COMT, MAOA, MAOB
10
Tyrosine metabolism p.1 (dopamine)
Hide members
10.3MAOB, MAOA, COMT
1110.3DRD2, DRD3, DRD4
12
Hide members
10.3DRD2, DRD3, DRD4
1310.2SLC6A3, MAOB, MAOA, DRD2
14
Hide members
10.2DRD2, MAOA, MAOB, SLC6A3
15
Hide members
10.2MAOA, MAOB, TPH1, TPH2
1610.2HTR2A, MAOA, SLC6A4, TPH1, TPH2
1710.2DRD4, DRD3, HTR2A, RXFP3
18
Hide members
10.1SLC6A4, HTR1B, HTR2A, DRD2, DRD3, DRD4
19
Hide members
10.0RXFP3, HTR1B, HTR2A, DRD2, DRD3, DRD4
20
Hide members
9.9RXFP3, HTR1B, HTR2A, DRD2, DRD3, DRD4
21
Hide members
9.9COMT, HTR1B, HTR2A, DRD2, DRD3, DRD4

Compounds for genes affiliated with Personality Disorder

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Personality Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 306)
idCompoundScoreTop Affiliating Genes
1mdma4410.5TPH1, MAOB, SLC6A3, SLC6A4, PRL, MAOA
2pergolide28 44 1112.5PRL, COMT, HTR1B, HTR2A, DRD2, DRD3
3methylphenidate44 49 1112.5COMT, DRD2, DRD4, MAOA, MAOB, SLC6A3
4mhpg4410.5SLC6A4, DRD4, MAOA, PRL, MAOB, COMT
5bromocriptine28 44 1112.5COMT, HTR1B, HTR2A, DRD3, DRD4, PRL
6cabergoline28 44 1112.5PRL, DRD4, COMT, HTR1B, HTR2A, DRD2
7MMDA1110.5HTR2A, SLC6A4, SLC6A3, MAOB, MAOA
8terguride28 4411.5HTR1B, DRD4, DRD3, PRL, DRD2, HTR2A
9fenfluramine28 44 1112.5TPH1, SLC6A4, PRL, HTR2A, HTR1B, TPH2
10ropinirole44 1111.5COMT, HTR1B, HTR2A, DRD2, DRD3, DRD4
11nemonapride49 44 2812.5DRD3, ANKK1, DRD4, PRL, DRD2
12homovanillic acid44 2411.5SLC6A4, PRL, COMT, TPH1, MAOA, MAOB
13lisuride28 44 1112.5HTR2A, DRD2, DRD3, DRD4, HTR1B, PRL
14d amphetamine4410.4SLC6A4, SLC6A3, MAOB, MAOA, DRD2
15remoxipride44 1111.4DRD3, DRD2, DRD4, PRL, HTR2A
16heroin44 49 1112.4COMT, DRD2, DRD3, DRD4, SLC6A3, SLC6A4
17bupropion44 49 11 2413.4ANKK1, DRD3, DRD2, COMT, SLC6A3, MAOB
18citalopram49 44 11 2413.4MAOB, MAOA, PRL, SLC6A3, SLC6A4, TPH1
19quetiapine44 49 28 11 2414.4HTR2A, DRD2, DRD3, DRD4, PRL, HTR1B
20pramipexole44 49 28 1113.4SLC6A3, PRL, COMT, HTR1B, HTR2A, DRD2
21raclopride44 2811.4HTR2A, DRD2, DRD3, DRD4, SLC6A3
22amphetamine44 1111.4DRD2, DRD4, MAOA, MAOB, SLC6A3, SLC6A4
23mptp4410.4SLC6A4, MAOB, MAOA, DRD2, COMT, DRD3
246-hydroxydopamine4410.4DRD3, SLC6A3, MAOA, DRD2, COMT, DRD4
25aripiprazole28 49 44 11 2414.4HTR2A, PRL, DRD4, DRD3, HTR1B, DRD2
26methamphetamine44 49 1112.4TPH1, SLC6A4, COMT, DRD2, DRD3, DRD4
27carbidopa44 2811.4TPH1, SLC6A3, MAOB, PRL, COMT
28apomorphine44 28 1112.4COMT, HTR1B, HTR2A, DRD2, DRD3, DRD4
29roxindole28 4411.3HTR1B, HTR2A, DRD2, DRD3, DRD4
30ziprasidone49 28 44 1113.3HTR1B, HTR2A, DRD2, DRD4, PRL, DRD3
31haloperidol44 28 2 49 1114.3SLC6A4, HTR2A, SLC6A3, MAOB, DRD2, DRD3
32paroxetine44 49 28 1113.3COMT, HTR1B, HTR2A, DRD3, DRD4, PRL
33olanzapine49 44 28 11 2414.3COMT, HTR1B, HTR2A, DRD2, DRD3, DRD4
34cocaine44 1111.3COMT, HTR1B, SLC6A4, DRD2, DRD3, DRD4
35fluoxetine49 44 28 1113.3HTR1B, HTR2A, SLC6A4, TPH1, TPH2, SLC6A3
36clozapine44 28 49 1113.3SLC6A4, HTR2A, DRD2, DRD3, DRD4, PRL
37piperazine44 1111.3DRD2, SLC6A3, HTR2A, DRD4, DRD3
38risperidone28 44 49 59 11 2415.3COMT, HTR1B, HTR2A, DRD2, DRD3, DRD4
39levodopa44 1111.3MAOA, PRL, DRD4, DRD3, DRD2, HTR1B
40maoa4410.3COMT, HTR1B, HTR2A, DRD2, DRD4, MAOA
41amisulpride44 28 1112.2HTR2A, DRD2, PRL, DRD3
42sulpiride44 28 1112.2DRD3, DRD4, PRL, SLC6A3, DRD2
43amine4410.2COMT, SLC6A4, TPH1, DRD3, MAOA, MAOB
44nicotine44 49 28 1113.2TPH1, SLC6A4, TTF2, MAOB, DRD2, SLC6A3
45trimipramine49 44 1112.2PRL, SLC6A4, DRD2, SLC6A3, HTR2A
465-hydroxytryptamine4410.2COMT, TPH1, HTR1B, HTR2A, DRD2, DRD4
47norepinephrine44 11 2412.1DRD3, DRD4, PRL, MAOA, MAOB, SLC6A3
48dopamine44 28 11 2413.1DRD2, HTR2A, HTR1B, COMT, TPH1, SLC6A4
49epinephrine44 11 2411.9COMT, MAOA, MAOB, DRD4, DRD2, LBR
50paliperidone44 1110.8PRL, DRD2, HTR2A, DRD3, DRD4

GO Terms for genes affiliated with Personality Disorder

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Sources:
16Gene Ontology
See all sources

Cellular components related to Personality Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058869.8RXFP3, HTR1B, HTR2A, DRD2, DRD3, DRD4
2integral to plasma membraneGO:0058879.7SLC6A4, RXFP3, HTR1B, HTR2A, DRD2, DRD3

Biological processes related to Personality Disorder according to GeneCards/GeneDecks:

(show all 46)
idNameGO IDScoreTop Affiliating Genes
1dopamine catabolic processGO:04242010.7SLC6A3, MAOA, COMT
2negative regulation of synaptic transmission, glutamatergicGO:05196710.7DRD2, HTR2A, HTR1B
3negative regulation of voltage-gated calcium channel activityGO:190138610.7DRD2, DRD4
4neurotransmitter biosynthetic processGO:04213610.7SLC6A3, MAOA, COMT
5response to histamineGO:03477610.7DRD4, DRD3, DRD2
6negative regulation of dopamine receptor signaling pathwayGO:06016010.7DRD2, DRD3
7positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.7DRD2, DRD4
8serotonin biosynthetic processGO:04242710.7TPH1, TPH2
9G-protein coupled receptor internalizationGO:00203110.7HTR1B, DRD3, DRD2
10dopamine metabolic processGO:04241710.7DRD2, DRD3, DRD4
11aromatic amino acid family metabolic processGO:00907210.7TPH2, TPH1
12negative regulation of protein secretionGO:05070910.7DRD2, DRD3, DRD4
13prepulse inhibitionGO:06013410.7SLC6A3, DRD3, DRD2
14behavioral response to cocaineGO:04814810.7DRD2, DRD3, DRD4
15negative regulation of serotonin secretionGO:01406310.7MAOB, HTR1B
16synaptic transmission, dopaminergicGO:00196310.7DRD4, DRD3, DRD2
17regulation of dopamine uptake involved in synaptic transmissionGO:05158410.7DRD3, DRD2
18arachidonic acid secretionGO:05048210.7DRD2, DRD3, DRD4
19regulation of dopamine secretionGO:01405910.7HTR1B, HTR2A, DRD2, DRD3
20response to cocaineGO:04222010.7HTR1B, DRD2, DRD3, SLC6A3
21monoamine transportGO:01584410.7SLC6A4, SLC6A3
22indolalkylamine biosynthetic processGO:04621910.7TPH1, TPH2
23negative regulation of adenylate cyclase activityGO:00719410.7DRD2, DRD3, DRD4
24social behaviorGO:03517610.7DRD3, DRD4, SLC6A4
25neurotransmitter catabolic processGO:04213510.7COMT, MAOA
26response to amphetamineGO:00197510.7DRD4, DRD3, DRD2
27circadian rhythmGO:00762310.6PRL, SLC6A4, TPH1, TPH2
28regulation of cAMP metabolic processGO:03081410.6DRD2, DRD3
29adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.6FLNA, DRD4, DRD3, DRD2
30adenohypophysis developmentGO:02198410.6DRD2, SLC6A3
31cellular calcium ion homeostasisGO:00687410.6DRD4, DRD3, DRD2, HTR2A
32behavioral response to ethanolGO:04814910.6DRD2, DRD4
33response to ethanolGO:04547110.6HTR1B, DRD3, PRL, MAOB, SLC6A3
34regulation of dopamine metabolic processGO:04205310.6DRD4, SLC6A3
35response to toxic substanceGO:00963610.5SLC6A4, MAOB, DRD2
36synaptic transmissionGO:00726810.5COMT, HTR1B, HTR2A, MAOA, SLC6A3
37negative regulation of cAMP biosynthetic processGO:03081810.5DRD4, HTR1B
38locomotory behaviorGO:00762610.5SLC6A3, DRD3, DRD2
39regulation of behaviorGO:05079510.5HTR1B, HTR2A
40response to iron ionGO:01003910.4DRD2, SLC6A3
41response to drugGO:04249310.4COMT, HTR2A, DRD2, DRD3, PRL, MAOB
42circadian regulation of gene expressionGO:03292210.3DRD2, DRD3
43elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148210.3DRD2, RXFP3
44bone remodelingGO:04684910.3HTR1B, TPH1
45small molecule metabolic processGO:04428110.2COMT, LBR, MAOA, MAOB, CLPS, TPH1
46positive regulation of renal sodium excretionGO:03581510.0DRD2, DRD3

Molecular functions related to Personality Disorder according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1serotonin bindingGO:05137810.4HTR2A, HTR1B
2tryptophan 5-monooxygenase activityGO:00451010.3TPH2, TPH1
3dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.3DRD2, DRD3, DRD4
4dopamine bindingGO:03524010.3SLC6A3, DRD4, DRD3, DRD2
5monoamine transmembrane transporter activityGO:00850410.3SLC6A4, SLC6A3
6drug bindingGO:00814410.3SLC6A3, HTR1B, HTR2A, DRD2, DRD3, DRD4
7primary amine oxidase activityGO:00813110.1MAOB, MAOA

Products for genes affiliated with Personality Disorder

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Sources for Personality Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet