MCID: PRS038
MIFTS: 58

Personality Disorder malady

Mental diseases category

Summaries for Personality Disorder

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Sources:
9Disease Ontology, 35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Personality disorders are a group of mental illnesses. they involve long-term patterns of thoughts and behaviors that are unhealthy and inflexible. the behaviors cause serious problems with relationships and work. people with personality disorders have trouble dealing with everyday stresses and problems. they often have stormy relationships with other people. the cause of personality disorders is unknown. however, genes and childhood experiences may play a role. the symptoms of each personality disorder are different. they can mild or severe. people with personality disorders may have trouble realizing that they have a problem. to them, their thoughts are normal, and they often blame others for their problems. they may try to get help because of their problems with relationships and work. treatment usually includes talk therapy and sometimes medicine.

MalaCards: Personality Disorder, also known as personality disorders, is related to borderline personality disorder and antisocial personality disorder. An important gene associated with Personality Disorder is TTF2 (transcription termination factor, RNA polymerase II), and among its related pathways are Dopamine metabolism and Serotonin clearance from the synaptic cleft. The compounds mhpg and minaprine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related mouse phenotypes are endocrine/exocrine gland and muscle.

Disease Ontology:9 A disease of mental health that involve long-term patterns of thoughts and behaviors that cause serious problems with relationships and work.

Wikipedia:66 Personality disorders are a class of mental disorders characterized by enduring maladaptive patterns of... more...

Aliases & Classifications for Personality Disorder

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Sources:
9Disease Ontology, 46Novoseek, 35MedlinePlus, 63UMLS, 28ICD9CM, 59SNOMED-CT, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

personality disorder 9
personality disorders 46 35 63
character disorder 9


External Ids:

Disease Ontology9 DOID:1510
ICD9CM28 301.89, 301.8
ICD1026 F60, F60.9

Related Diseases for Personality Disorder

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Personality Disorder family:

Multiple Personality Disorder

Diseases related to Personality Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1borderline personality disorder31.8SLC6A4, CLPS, MAOA, HTR1B, TTF2
2antisocial personality disorder31.4SLC6A3, SLC6A4, MAOA, HTR1B, HTR2A, TTF2
3obsessive-compulsive personality disorder31.2CLPS, SLC6A4
4schizophrenia31.1HTR2A, COMT
5social phobia31.0COMT, MAOA, SLC6A4
6substance abuse30.8SLC6A3, SLC6A4
7substance dependence30.8COMT, SLC6A4, SLC6A3
8anxiety disorder30.8MAOA, SLC6A4
9conduct disorder30.6TTF2, COMT, MAOA, SLC6A3, SLC6A4
10cocaine dependence30.6SLC6A3, SLC6A4
11bipolar disorder30.6HTR2A, SLC6A4
12eating disorder30.6HTR2A, COMT, SLC6A4, SLC6A3
13pathological gambling30.5SLC6A3
14alcohol dependence30.5HTR1B, HTR2A, SLC6A4, MAOA
15bulimia nervosa30.5HTR2A, COMT, MAOA, SLC6A4, HTR1B
16obsessive-compulsive disorder30.5SLC6A3, SLC6A4, MAOA, COMT, HTR1B, HTR2A
17dysthymic disorder30.4MAOA, HTR2A
18anorexia nervosa30.4SLC6A4, MAOA, COMT, HTR2A
19panic disorder30.4HTR2A, TTF2, COMT, SLC6A4, MAOA
20intermittent explosive disorder30.3HTR1B
21attention deficit hyperactivity disorder30.3TTF2, HTR2A, HTR1B, SLC6A3, SLC6A4, MAOA
22drug dependence30.2SLC6A4, MAOA, SLC6A3
23mood disorder30.1SLC6A4, HTR2A, HTR1B, COMT, SLC6A3, MAOA
24alcohol abuse30.1SLC6A4, COMT, SLC6A3
25chronic fatigue syndrome30.1SLC6A4, MAOA
26seasonal affective disorder30.1HTR2A, SLC6A4
27cocaine abuse30.0SLC6A4, SLC6A3
28obesity30.0CLPS, SLC6A3, HTR2A, COMT, MAOA, TTF2
29melancholia29.9MAOA
30paranoid schizophrenia29.9COMT
31nicotine dependence29.9SLC6A4
32oppositional defiant disorder29.9SLC6A3
33dementia29.8MAOA, HTR2A, TTF2, SLC6A3, COMT
34asthma29.8TTF2, HTR2A
35psychotic disorder29.8SLC6A3, MAOA, COMT, TTF2, HTR2A, SLC6A4
36schizoaffective disorder29.8COMT, SLC6A4, HTR2A
37migraine29.8HTR1B, HTR2A, COMT, MAOA, SLC6A3, SLC6A4
38parkinson's disease29.7MAOA, COMT, SLC6A3
39alzheimer's disease29.6COMT, SLC6A3, TTF2, HTR2A, MAOA, SLC6A4
40multiple personality disorder11.0
41schizotypal personality disorder11.0
42narcissistic personality disorder10.9
43avoidant personality disorder10.8
44dependent personality disorder10.6
45histrionic personality disorder10.6
46paranoid personality disorder10.5
47schizoid personality disorder10.5
48alexithymia10.5
49major depressive disorder10.4
50agoraphobia10.4

Graphical network of the top 20 diseases related to Personality Disorder:



Diseases related to personality disorder

Symptoms for Personality Disorder

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Drugs & Therapeutics for Personality Disorder

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Personality Disorder

Drug clinical trials:

Search ClinicalTrials for Personality Disorder

Search NIH Clinical Center for Personality Disorder

Search CenterWatch for Personality Disorder

Genetic Tests for Personality Disorder

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Anatomical Context for Personality Disorder

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Sources:
34MalaCards
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MalaCards organs/tissues related to Personality Disorder:

34
Brain, Testes, Eye, Temporal lobe, Amygdala, Caudate nucleus, Bone, Cortex, Pituitary, Heart, Prefrontal cortex, Endothelial, Ovary, Thalamus, Breast

Animal Models for Personality Disorder or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Personality Disorder:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.1HTR2A, HTR1B, SLC6A4, SLC6A3
2MP:00053697.8HTR2A, HTR1B, SLC6A4, SLC6A3
3MP:00053866.6CLPS, HTR2A, HTR1B, COMT, MAOA, SLC6A4

Publications for Personality Disorder

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Sources:
53PubMed
See all sources

Articles related to Personality Disorder:

(show top 50)    (show all 1710)
idTitleAuthorsYear
1
Emotional cascades as prospective predictors of dysregulated behaviors in borderline personality disorder. (23046043)
2013
2
Distinguishing bipolar II depression from major depressive disorder with comorbid borderline personality disorder: demographic, clinical, and family history differences. (24107761)
2013
3
A developing world perspective on homicide and personality disorder. (24166685)
2013
4
Medial prefrontal dysfunction and prolonged amygdala response during instructed fear processing in borderline personality disorder. (22404662)
2013
5
Schizotypal personality disorder. (22928856)
2013
6
A Further Validation of the Minnesota Borderline Personality Disorder Scale. (24364505)
2013
7
Comorbidity of social anxiety disorder and antisocial personality disorder in the National Epidemiological Survey on Alcohol and Related Conditions (NESARC). (24384071)
2013
8
A Case of Depressive Personality Disorder: Aligning Theory, Practice, and Clinical Research. (23957236)
2013
9
Getting the word out about treating borderline personality disorder: an online information resource. (23334680)
2013
10
Resident didactic education in borderline personality disorder: is it sufficient? (23820919)
2013
11
Trait anxiety modulates fronto-limbic processing of emotional interference in borderline personality disorder. (23459637)
2013
12
Antisocial Personality Disorder Subscale (Chinese Version) of the Structured Clinical Interview for the DSM-IV Axis II disorders: validation study in Cantonese-speaking Hong Kong Chinese. (23807628)
2013
13
Alexithymia as a mediator between attachment and the development of borderline personality disorder in adolescence. (23013337)
2012
14
Gender Differences in a Clinical Sample of Patients with Borderline Personality Disorder. (22494170)
2012
15
The association of 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR gene polymorphisms and antisocial personality disorder in male heroin-dependent Chinese subjects. (22138326)
2012
16
Management of borderline personality disorder. (23027916)
2012
17
Avoidant personality disorder in individuals with generalized social anxiety disorder: what does it add? (22705954)
2012
18
Platelet protein kinase C and brain-derived neurotrophic factor levels in borderline personality disorder patients. (22633012)
2012
19
Borderline Personality Disorder (BPD) diagnosis with the self-report Personality Diagnostic Questionnairea894+(PDQ-4+): confirmation of the 3-factor structure. (22508070)
2012
20
Diagnosis of antisocial personality disorder and criminal responsibility. (21903271)
2011
21
Diagnosis and subtypes of adolescent antisocial personality disorder. (20420477)
2010
22
Incremental effect for antisocial personality disorder genetic risk combining 5-HTTLPR and 5-HTTVNTR polymorphisms. (20363030)
2010
23
Factor structure and diagnostic efficiency of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria for avoidant personality disorder in Hispanic men and women with substance use disorders. (19683617)
2009
24
5-HT1A receptor gene C -1019 G polymorphism and amygdala volume in borderline personality disorder. (18387137)
2008
25
Clozapine in treatment-refractory obsessive-compulsive disorder with comorbid schizotypal personality disorder. (19398826)
2008
26
A time series evaluation of the treatment of histrionic personality disorder with cognitive analytic therapy. (17877864)
2007
27
Similar or disparate brain patterns? The intra-personal EEG variability of three women with multiple personality disorder. (16929711)
2006
28
Etiology of antisocial personality disorder: benefits for society from an evolutionary standpoint. (16006050)
2005
29
Borderline personality disorder, antisocial personality disorder and risk-taking among heroin users: findings from the Australian Treatment Outcome Study (ATOS). (15072810)
2004
30
Misdiagnosis of Asperger syndrome as anankastic personality disorder. (12540134)
2002
31
Diagnosing antisocial personality disorder among substance abusers: the scid versus the MCMI-II. (11727884)
2001
32
Schizotypal personality disorder and MRI abnormalities of temporal lobe gray matter. (10356620)
1999
33
Gender differences in the relationship of antisocial personality disorder criteria to Psychopathy Checklist-Revised scores. (9573521)
1998
34
Acute and transient psychotic disorder: comorbidity with personality disorder. (9021000)
1996
35
Death rates in 71 men with antisocial personality disorder. A comparison with general population mortality. (8742541)
1996
36
m-Chlorophenylpiperazine challenge in borderline personality disorder: relationship of neuroendocrine response, behavioral response, and clinical measures. (8879471)
1996
37
Schizoid personality disorder after prenatal exposure to famine. (8942466)
1996
38
Re: Psychiatrists' attitudes to multiple personality disorder. (8681274)
1995
39
Antisocial personality disorder as a prognostic factor for pharmacotherapy of cocaine dependence. (8082553)
1994
40
Child abuse and multiple personality disorder. (8185019)
1994
41
Drinking outcomes of alcohol abusers diagnosed as antisocial personality disorder. (7978086)
1994
42
Multiple personality disorder and satanic ritual abuse. (8135697)
1993
43
Use of the MMPI to distinguish genuine from factitious multiple personality disorder. (8234591)
1993
44
Personality disorders in panic with agoraphobia and major depression. (1600407)
1992
45
Expressive therapy in conjunction with psychotherapy in the treatment of persons with multiple personality disorder. (2252072)
1990
46
Multiple personality disorder. (2611585)
1989
47
Differences between multiple personality disorder and other diagnostic groups on structured interview. (2760600)
1989
48
Autohypnotic resolution of an incipient relapse in an integrated multiple personality disorder patient: a clinical note. (3228064)
1988
49
The relationship of histrionic personality disorder to antisocial personality and somatization disorders. (3717392)
1986
50
Clinical phobias and avoidant personality disorder among alcoholics admitted to an alcoholism rehabilitation setting. (3791123)
1986

Variations for Personality Disorder

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Expression for genes affiliated with Personality Disorder

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Personality Disorder

Search GEO for disease gene expression data for Personality Disorder.

Pathways for genes affiliated with Personality Disorder

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 31KEGG, 61Thomson Reuters, 52PharmGKB
See all sources

Pathways related to Personality Disorder according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6COMT, MAOA
2
Show member pathways
9.6COMT, MAOA
3
Show member pathways
catecholamine biosynthesis39
9.6MAOA, COMT
4
Show member pathways
phenylalanine utilization39
noradrenaline and adrenaline degradation39
phenylalanine degradation IV39
9.6MAOA, COMT
59.6MAOA, COMT
69.6MAOA, COMT
7
Show member pathways
9.3HTR1B, HTR2A
8
Show member pathways
9.3SLC6A3, MAOA
99.1SLC6A4, MAOA, HTR2A
10
Show member pathways
Serotonin Transporter Activity39
8.9SLC6A3, SLC6A4, MAOA
11
Show member pathways
8.8COMT, MAOA, SLC6A3
128.5HTR2A, HTR1B, MAOA, SLC6A4
13
Show member pathways
7.3SLC6A3, SLC6A4, MAOA, COMT, HTR1B, HTR2A

Compounds for genes affiliated with Personality Disorder

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Sources:
46Novoseek, 12DrugBank, 30IUPHAR, 25HMDB, 52PharmGKB, 62Tocris Bioscience
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Compounds related to Personality Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 172)
idCompoundScoreTop Affiliating Genes
1mhpg469.4MAOA, COMT, SLC6A4
2minaprine46 1210.4SLC6A4, HTR2A, MAOA
3naratriptan46 30 1211.3HTR2A, HTR1B, MAOA
4mcpp469.2HTR2A, HTR1B, SLC6A4
5carbon-11469.2SLC6A3, SLC6A4, MAOA
6p-chloroamphetamine469.2SLC6A3, MAOA, SLC6A4
7phentermine46 1210.2SLC6A3, MAOA, SLC6A4
8d amphetamine469.2SLC6A4, SLC6A3, MAOA
9pindolol46 30 1211.2HTR2A, HTR1B, SLC6A4
10pseudoephedrine46 25 1211.2SLC6A3, SLC6A4, MAOA
11mdma469.1MAOA, SLC6A4, SLC6A3
12maprotiline46 52 1211.1SLC6A4, SLC6A3, MAOA
13methysergide46 30 1211.1HTR2A, HTR1B, MAOA
14tryptamine46 30 2511.0HTR2A, HTR1B, MAOA
15Serotonin259.0HTR1B, HTR2A, SLC6A4, MAOA
16amine468.9COMT, HTR1B, SLC6A4, MAOA
17duloxetine46 52 30 1211.9HTR2A, SLC6A4, SLC6A3
18fenfluramine46 30 1210.9HTR2A, SLC6A4, HTR1B
19ropinirole46 129.9COMT, HTR2A, HTR1B
20methylphenidate46 52 1210.8SLC6A4, MAOA, SLC6A3, COMT
21tyramine46 30 2510.8SLC6A4, MAOA, COMT, SLC6A3
22methamphetamine46 52 1210.8SLC6A3, COMT, SLC6A4, MAOA
23mianserin46 30 1210.8HTR2A, MAOA, SLC6A4
24trimipramine46 52 1210.8SLC6A4, SLC6A3, HTR2A
25mptp468.8SLC6A4, COMT, MAOA, SLC6A3
26amitriptyline46 30 52 1211.6SLC6A4, HTR2A, MAOA, SLC6A3
27desipramine46 52 1210.6HTR2A, MAOA, SLC6A4, SLC6A3
28citalopram46 52 25 1211.6MAOA, SLC6A4, SLC6A3, HTR2A
29imipramine46 30 52 25 1212.6SLC6A3, SLC6A4, MAOA, HTR2A
30levodopa46 129.5HTR1B, COMT, MAOA, SLC6A3
31nefazodone46 52 1210.5SLC6A4, SLC6A3, HTR1B, HTR2A
32escitalopram46 52 25 1211.5SLC6A4, HTR2A, SLC6A3
33quetiapine46 52 30 25 1212.5HTR2A, HTR1B, SLC6A4, SLC6A3
34pramipexole46 30 52 1211.5COMT, SLC6A3, HTR1B, HTR2A
35carbon468.5COMT, TTF2, SLC6A4, SLC6A3, MAOA
36nicotine46 30 52 1211.5MAOA, TTF2, COMT, SLC6A4, SLC6A3
37apomorphine30 46 1210.5HTR2A, HTR1B, COMT, SLC6A3
38bromocriptine46 30 1210.4SLC6A3, COMT, HTR1B, HTR2A
39fluvoxamine46 52 1210.2MAOA, COMT, HTR2A, SLC6A4, SLC6A3
40clomipramine46 52 1210.2SLC6A3, SLC6A4, MAOA, HTR1B, HTR2A
41fluoxetine46 52 30 1211.2SLC6A3, SLC6A4, HTR1B, MAOA, HTR2A
42venlafaxine46 52 25 1211.1SLC6A3, HTR2A, HTR1B, COMT, SLC6A4
43risperidone46 52 30 62 25 1213.1SLC6A3, SLC6A4, COMT, HTR1B, HTR2A
44olanzapine46 52 30 25 1212.1HTR2A, SLC6A3, SLC6A4, COMT, HTR1B
45norepinephrine46 25 1210.1HTR2A, COMT, SLC6A4, SLC6A3, MAOA
46clozapine46 30 52 1211.1COMT, HTR1B, SLC6A4, SLC6A3, HTR2A
47maoa467.7SLC6A4, HTR2A, HTR1B, COMT, MAOA, SLC6A3
48paroxetine46 52 30 1210.7HTR2A, SLC6A3, HTR1B, COMT, MAOA, SLC6A4
495-hydroxytryptamine467.7HTR2A, HTR1B, SLC6A3, SLC6A4, COMT, MAOA
50dopamine46 30 25 1210.7SLC6A4, MAOA, SLC6A3, HTR2A, COMT, HTR1B

GO Terms for genes affiliated with Personality Disorder

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Sources:
17Gene Ontology
See all sources

Cellular components related to Personality Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.1SLC6A3, SLC6A4, HTR1B, HTR2A

Biological processes related to Personality Disorder according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1neurotransmitter catabolic processGO:0421359.8MAOA, COMT
2vasoconstrictionGO:0423109.4SLC6A4, HTR1B
3regulation of dopamine secretionGO:0140599.4HTR1B, HTR2A
4memoryGO:0076139.4SLC6A4, HTR2A
5monoamine transportGO:0158449.4SLC6A4, SLC6A3
6negative regulation of synaptic transmission, glutamatergicGO:0519679.4HTR1B, HTR2A
7regulation of behaviorGO:0507959.3HTR2A, HTR1B
8dopamine catabolic processGO:0424209.1SLC6A3, MAOA, COMT
9neurotransmitter biosynthetic processGO:0421369.1SLC6A3, MAOA, COMT
10response to cocaineGO:0422208.8SLC6A3, HTR1B
11response to drugGO:0424938.4SLC6A3, SLC6A4, COMT, HTR2A
12synaptic transmissionGO:0072687.9HTR2A, HTR1B, COMT, MAOA, SLC6A3

Molecular functions related to Personality Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serotonin receptor activityGO:0049939.3HTR1B, HTR2A
2monoamine transmembrane transporter activityGO:0085049.1SLC6A3, SLC6A4
3serotonin bindingGO:0513789.0HTR1B, HTR2A
4drug bindingGO:0081448.5SLC6A3, HTR1B, HTR2A

Products for genes affiliated with Personality Disorder

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Personality Disorder

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet