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Personality Disorder malady
28 genes, 3 tissues, 283 related diseases, 10 phenotypes, 61 articles, clinical trials.

Summaries for Personality Disorder

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6Disease Ontology, 23MedlinePlus, 44Wikipedia, 22MalaCards
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MedlinePlus: Personality disorders are long-term patterns of thoughts and behaviors that cause serious problems with relationships and work. people with personality disorders have difficulty dealing with everyday stresses and problems. they often have stormy relationships with other people. the exact cause of personality disorders is unknown. however, genes and childhood experiences may play a role. symptoms vary widely depending on the specific type of personality disorder. treatment usually includes talk therapy and sometimes medicine.23

MalaCards: Personality Disorder, also known as personality disorders, is related to borderline personality disorder and antisocial personality disorder. An important gene associated with Personality Disorder is TTF2 (transcription termination factor, RNA polymerase II), and among its related pathways are Tyrosine metabolism p.1 (dopamine) and Tyrosine metabolism p.1 (dopamine). The compounds nicotine and methylphenidate have been mentioned in the context of this disorder. Affiliated tissues include brain, amygdala and pituitary, and related mouse phenotypes are endocrine/exocrine gland and taste/olfaction.

Disease Ontology: A disease of mental health that involve long-term patterns of thoughts and behaviors that cause serious problems with relationships and work.6

Wikipedia: Personality disorder refers to a class of personality types and enduring behaviors associated with...44 more...

Aliases & Descriptions for Personality Disorder

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6Disease Ontology, 32Novoseek , 23MedlinePlus, 43UMLS, 19ICD9CM, 40SNOMED-CT
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Aliases & Descriptions:

personality disorder 6
personality disorders 32 23 43
character disorder 6

External Ids:

ICD9CM19 301.8, 301.89
SNOMED-CT40 191776009, 191770003, 268635005 268759009, more

Related Diseases for Personality Disorder

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13GeneCards, 14GeneDecks
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Diseases related to personality disorder by text searches and GeneDecks gene sharing:

(show top 50)    (show all 280)
idRelated DiseaseScoreTop Affiliating Genes
1borderline personality disorder33.7MAOA, HTR1B, TPH1, COMT, PRL, SLC6A4
2antisocial personality disorder32.9MAOA, HTR1B, HTR2A, DRD2, DRD4, SLC6A4
3schizotypal personality disorder32.1RXFP3, COMT, PSAT1
4schizophrenia28.9HTR2A, DRD3, COMT
5attention deficit hyperactivity disorder27.8DRD4, SLC6A3
6conduct disorder27.8MAOA, HTR1B, SLC6A4
7alcoholism26.4MAOA, MAOB, HTR1A, HTR1B, HTR2A, HTR2C
8substance dependence24.9BDNF, MAOA, HTR1B, TPH1, DRD2, DRD3
9substance abuse23.1BDNF, MAOA, MAOB, HTR1A, HTR1B, HTR3A
10alcohol dependence22.6BDNF, IL6, MAOA, MAOB, HTR1A, HTR1B
11adhd21.2BDNF, IL6, MAOA, MAOB, HTR1A, HTR1B
12major depressive disorder19.6BGLAP, BDNF, IL6, MAOA, MAOB, HTR1A
13dysthymic disorder13.6MAOA, HTR2A
14leptin receptor deficiency13.6DRD2, SLC6A3
15separation anxiety disorder13.6DRD4, SLC6A3
16alcoholic psychosis13.5HTR2A, SLC6A3, SLC6A4
17fetal akinesia syndrome x-linked13.5MAOB, COMT
18schizophreniform disorder13.5DRD2, PRL
19peripartum cardiomyopathy13.5DRD2, PRL
20delusional disorder13.5DRD3, DRD4
21sepiapterin reductase deficiency13.5TPH1, DRD2, SLC6A3
22generalized anxiety disorder13.5HTR1A, SLC6A4
23tic disorder13.5HTR2A, DRD2, DRD4
24opiate dependence13.5DRD2, DRD3
25endogenous depression13.4MAOA, CRH, SLC6A4
26myoclonus-dystonia13.4DRD2, DRD3, DRD4
27movement disease13.4DRD2, DRD3, SLC6A3
28novelty seeking personality13.4MAOA, DRD2, DRD4, COMT
29conduction disease13.4MAOA, DRD4, SLC6A3, SLC6A4
30metachromatic leukodystrophy13.3HTR1A, SLC6A3, SLC6A4
31bulimia nervosa13.3HTR3A, COMT, SLC6A4
32hypothalamic disease13.3CRH, PRL
33neonatal abstinence syndrome13.3DRD2, CRH
34essential tremor13.3TPH1, DRD3, COMT, SLC6A3
35anovulation13.3DRD2, CRH, PRL
36anorexia nervosa13.3BDNF, HTR2A
37dyslexia13.3DRD2, DRD3, DRD4, SLC6A3
38melancholia13.2MAOA, CRH, PRL, SLC6A4
39pituitary-dependent cushing's disease13.2CRH, PRL
40cognitive disease13.2MAOA, MAOB, HTR1A, COMT
41anxiety-related personality traits13.2BDNF, COMT, SLC6A4
42major affective disorder13.1HTR2A, HTR3A, TPH1, SLC6A3
43pulmonary hypertension13.1HTR1B, HTR3A, TPH1, SLC6A4
44gastroparesis13.1HTR3A, DRD2, PRL
45bipolar disorder13.1BDNF, HTR1A, SLC6A4
46spinocerebellar ataxia type 313.0HTR1A, HTR3A, SLC6A3
47cluster headache13.0HTR1B, HTR1D, HTR3A, PRL
48central nervous system disease13.0BDNF, HTR2A, SLC6A3, SLC6A4
49neuroleptic malignant syndrome13.0HTR1A, HTR2A, HTR3A, DRD2
50progressive supranuclear palsy13.0HTR1A, HTR3A, DRD2, SLC6A3

Graphical network of the top 20 diseases related to personality disorder:



Graphical network of diseases related to personality disorder

Clinical Features for Personality Disorder

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Drugs & Therapeutics for Personality Disorder

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for personality disorder

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Genetic Tests for Personality Disorder

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Anatomical Context for Personality Disorder

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22MalaCards
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MalaCards organs/tissues related to personality disorder:

22
Brain, Amygdala, Pituitary

Phenotypes for genes affiliated with Personality Disorder

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25MGI
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MGI Mouse Phenotypes related to personality disorder:

25
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1endocrine/exocrine gland phenotypeMP:00053799.8SNAP25, HTR2A, HTR1B
2taste/olfaction phenotypeMP:00053949.2SLC6A3, SNAP25, DRD2, TPH2, BDNF
3adipose tissue phenotypeMP:00053758.5DRD2, TPH2, TPH1, HTR2C, IL6, DRD3
4muscle phenotypeMP:00053697.9SLC6A4, SLC6A3, SNAP25, DRD2, TPH1, HTR2C
5cardiovascular system phenotypeMP:00053857.2SLC6A4, COMT, CRP, SNAP25, DRD3, DRD2
6integument phenotypeMP:00107716.3SLC6A4, SLC6A3, PRL, CRH, SNAP25, DRD2
7growth/size phenotypeMP:00053786.1DRD3, SNAP25, CRH, SLC6A3, SLC6A4, DRD2
8nervous system phenotypeMP:00036316.1DRD4, SNAP25, CRH, COMT, PRL, SLC6A3
9behavior/neurological phenotypeMP:00053864.8BDNF, DRD2, DRD3, DRD4, SNAP25, CRH
10homeostasis/metabolism phenotypeMP:00053764.7DRD3, DRD4, SNAP25, CRH, CRP, COMT

Publications for genes affiliated with Personality Disorder

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35PubMed
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Articles related to personality disorder:

(show top 50)    (show all 61)
idTitleAuthorsYearAffiliating Genes
1Synaptosomal-associated protein 25 gene polymorphisms and antisocial personality disorder: association with temperament and psychopa thy. (21756448)Basoglu C.... Munir K.M.2011SNAP25
2Association between a serotonin transporter promoter polymorphism (5HTTLPR) and personality disorder traits in a community sample. (21450307)Blom R.M.... Nestadt G.2011SLC6A4
3A novel balanced chromosomal translocation found in s ubjects with schizophrenia and schizotypal personality disorder: altered l-seri ne level associated with disruption of PSAT1 gene expression. (20955740)Ozeki Y.... Sawa A.2011PSAT1
4Fluoxetine response in impulsive-aggressive behavior and serotonin transporter polymorphism in personality disorder. (20010449)Silva H.... Bustamante M.L.2010HTR2C, HTR1B, TPH1
5Interaction between ALDH2*1*1 and DRD2/ANKK1 TaqI A1A 1 genes may be associated with antisocial personality disorder not co-morbid wi th alcoholism. (21070510)Lu R.B.... Ko H.C.2010ALDH2, DRD2
6Child maltreatment moderates the association of MAOA with symptoms of depression and antisocial personality disorder. (20175604)Beach S.R.... Philibert R.A.2010MAOA
7Incremental effect for antisocial personality disorde r genetic risk combining 5-HTTLPR and 5-HTTVNTR polymorphisms. (20363030)Garcia L.F.... GarcA-a O.2010SLC6A4
8The catechol o-methyltransferase (COMT) val(158)met p olymorphism modulates the association of serious life events (SLE) and impulsiv e aggression in female patients with borderline personality disorder (BPD). (19906087)Wagner S.... TadiA8 A.2010COMT
9Tryptophan-hydroxylase 2 haplotype association with b orderline personality disorder and aggression in a sample of patients with pers onality disorders and healthy controls. (20451217)Mercedes Perez-Rodriguez M.... Siever L.J.2010TPH2
10Modulatory role of the brain-derived neurotrophic fac tor ValMet polymorphism on the effects of serious life events on impulsive aggr ession in borderline personality disorder. (19817874)Wagner S.... TadiA8 A.2009BDNF
11The 5-HTTLPR Polymorphism modulates the association of serious life events (SLE) and impulsivity in patients with Borderline Personality Disorder. (19358998)Wagner S.... TadiA8 A.2009SLC6A4
12COMT polymorphisms in impulsively violent offenders w ith antisocial personality disorder. (20038933)Vevera J.... Stopka P.2009COMT
13MAOA-uVNTR polymorphism may modify the protective effect of ALDH2 gene against alcohol dependence in antisocial personality disorder. (19302089)Lee S.Y.... Lu R.B.2009ALDH2, MAOA
14Psychopathy and personality. An investigation of the relationship between the NEO-Five Factor Inventory (NEO-FFI) and the Psychopathy Checklist-Revised (PCL-R) in a hospitalized sample of male offenders with personality disorder. (18803292)Pereira N.... Duggan C.2008TTF2
15Association analysis of SCN9A gene variants with borderline personality disorder. (18439623)Tadic A.... Dahmen N.2008SCN9A
16The tryptophan hydroxylase-1 A218C polymorphism is associated with diagnosis, but not suicidal behavior, in borderline personality disorder. (18506706)Wilson S.T.... Mann J.J.2008TPH1
17Serotonin genes and gene-gene interactions in borderline personality disorder in a matched case-control study. (19032968)Ni X.... Kennedy J.L.2008HTR2C, MAOA, HTR1B
18Failure to detect an association between the serotonin transporter gene and borderline personality disorder. (17137596)Pascual J.C.... Baiget M.2008SLC6A4
19Interaction between gene variants of the serotonin transporter promoter region (5-HTTLPR) and catechol O-methyltransferase (COMT) in borderline personality disorder. (18756498)Tadic A.... Dahmen N.2008COMT, SLC6A4
20Emotionally controlled decision-making and a gene variant related to serotonin synthesis in women with borderline personality disorder. (18826425)Maurex L.... Ohman A.2008TPH1
21An examination of the factor structure of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, narcissistic personality disorder criteria: one or two factors? (18243885)Miller J.D.... Pilkonis P.A.2008TTF2
22Catechol-O-methyltransferase Val158Met genotype in healthy and personality disorder individuals: Preliminary results from an examination of cognitive tests hypothetically differentially sensitive to dopamine functions. (19300629)Leung W.W.... Harvey P.D.2007COMT
23Serotonin transporter polymorphism and fluoxetine effect on impulsiveness and aggression in borderline personality disorder. (17597424)Silva H.... Roa N.2007SLC6A4
24Association between the serotonin transporter gene and personality traits in borderline personality disorder patients evaluated with Zuckerman-Zuhlman Personality Questionnaire (ZKPQ). (18004675)Pascual J.C.... Perez V.2007SLC6A4
25Monoamine oxidase a gene is associated with borderline personality disorder. (17417058)Ni X.... Kennedy J.L.2007MAOA
26Catechol-O-methyltransferase Val158Met genotype variation is associated with prefrontal-dependent task performance in schizotypal personality disorder patients and comparison groups. (16691129)Minzenberg M.J.... Siever L.J.2006COMT
27A dopamine transporter polymorphism is a risk factor for borderline personality disorder in depressed patients. (16623961)Joyce P.R.... Kennedy M.A.2006SLC6A3
28Association of C-reactive protein elevation with trait aggression and hostility in personality disordered subjects: a pilot study. (15993896)Coccaro E.F.2006CRP
29Bone mineral density, bone turnover, and osteoprotegerin in depressed women with and without borderline personality disorder. (17012519)Kahl K.G.... Schweiger U.2006BGLAP
30Preliminary evidence for an association between a dopamine D3 receptor gene variant and obsessive-compulsive personality disorder in patients with major depression. (16583407)Light K.J.... Kennedy M.A.2006DRD3
31Exploratory factor analysis of borderline personality disorder criteria in hospitalized adolescents. (16490567)Becker D.F.... Grilo C.M.2006TTF2
32Blunted hormone responses to Ipsapirone are associate d with trait impulsivity in personality disorder patients. (16123761)Minzenberg M.J.... Siever L.J.2006PRL
33Serotonin 2A receptor gene is associated with personality traits, but not to disorder, in patients with borderline personality disorder. (17000047)Ni X.... Kennedy J.L.2006HTR2A
34Bone mineral density, markers of bone turnover, and cytokines in young women with borderline personality disorder with and without comorbid major depressive disorder. (15625216)Kahl K.G.... Schweiger U.2005BGLAP
35Visceral fat deposition and insulin sensitivity in depressed women with and without comorbid borderline personality disorder. (15911903)Kahl K.G.... Schweiger U.2005IL6
36Cluster B personality disorders are associated with allelic variation of monoamine oxidase A activity. (15870836)Jacob C.P.... Lesch K.P.2005MAOA
37Fine mapping of the 5p13 locus linked to schizophrenia and schizotypal personality disorder in a Puerto Rican family. (16094256)Bespalova I.N.... Silverman J.M.2005RXFP3
38The childhood-onset neuropsychiatric background to adulthood psychopathic traits and personality disorders. (15723027)Soderstrom H.... Forsman A.2005TTF2
39Association of serotonin transporter promoter gene polymorphism with violence: relation with personality disorders, impulsivity, and childhood ADHD psychopathology. (15211560)Retz W.... Rosler M.2004SLC6A4
40Dimensions of personality disorders in offenders. (15614323)Ullrich S.... Marneros A.2004TTF2
41A possible effect of amisulpride on a prolactinoma gr owth in a woman with borderline personality disorder. (15225684)Perroud N.... Huguelet P.2004PRL
42Neither antisocial personality disorder nor antisocial alcoholism is associated with the MAO-A gene in Han Chinese males. (12824808)Lu R.B.... Shih J.C.2003MAOA
43Hyperresponsiveness of hypothalamic-pituitary-adrenal axis to combined dexamethasone/corticotropin-releasing hormone challenge in fe male borderline personality disorder subjects with a history of sustained child hood abuse. (12460693)Rinne T.... van den Brink W.2002CRH
445-HT1A dysfunction in borderline personality disorder . (12171388)Hansenne M.... Ansseau M.2002PRL, HTR1A
45Cluster C personality disorder has no independent effect on striatal dopamine transporter densities in major depression. (11374331)Laasonen-Balk T.... Tiihonen J.2001SLC6A3
46Impulsive traits and 5-HT2A receptor promoter polymorphism in alcohol dependents: possible association but no influence of personality disorders. (11287798)Preuss U.W.... Soyka M.2001HTR2A
47Gender differences in the relationship of antisocial personality disorder criteria to Psychopathy Checklist-Revised scores. (9573521)Rutherford M.J.... McKay J.R.1998TTF2
48Serotonin transporter gene variants in alcohol-dependent subjects with dissocial personality disorder. (9627746)Sander T.... Schmidt L.G.1998SLC6A4
49Relationship of prolactin response to d-fenfluramine to behavioral and questionnaire assessments of aggression in personality-disord ered men. (8830948)Coccaro E.F.... Hauger R.L.1996PRL
50Serotonergic responsivity and behavioral dimensions i n antisocial personality disorder with substance abuse. (2397249)Moss H.B.... Panzak G.L.1990PRL

Expression for genes affiliated with Personality Disorder

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Personality Disorder

Pathways for genes affiliated with Personality Disorder

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41Thomson Reuters, 10EMD Millipore, 20KEGG, 38Reactome, 34PharmGKB, 36QIAGEN
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Pathways related to personality disorder according to GeneDecks:

(show all 12)
idPathwayScoreTop Affiliating Genes
1Tyrosine metabolism p.1 (dopamine)4110.1COMT, MAOB, MAOA
2Tyrosine metabolism p.1 (dopamine)1010.0COMT, MAOB, MAOA
3Tyrosine metabolism2010.0MAOA, MAOB, COMT
4Histidine metabolism209.8MAOA, MAOB, ALDH2
5Amine Oxidase reactions389.8MAOA, MAOB
6Glycine, serine and threonine metabolism209.8PSAT1, MAOB, MAOA
7Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics349.7SNAP25, DRD4, DRD3, DRD2
8Tryptophan metabolism209.6TPH2, TPH1, ALDH2, MAOB, MAOA
9Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics349.3MAOA, HTR1A, HTR1D, HTR2A, TPH1, TPH2
10Amine ligand-binding receptors388.9DRD4, DRD3, DRD2, HTR2C, HTR2A, HTR1D
11Neuroactive ligand-receptor interaction208.6PRL, DRD4, DRD3, DRD2, HTR2C, HTR2A
12Intracellular Calcium Signaling367.6HTR3A, HTR2C, HTR2A, HTR1D, HTR1B, HTR1A

Compounds for genes affiliated with Personality Disorder

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32Novoseek , 34PharmGKB, 9DrugBank, 18HMDB, 42Tocris Bioscience
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Compounds related to personality disorder according to GeneDecks:

(show top 50)    (show all 331)
idCompoundScoreTop Affiliating Genes
1nicotine32 34 9 9 13.4CRH
2methylphenidate32 9 9 11.6MAOA, MAOB, DRD2, DRD4, COMT, SLC6A3
3bromocriptine32 9 9 11.5HTR1A, HTR2A, HTR2C, DRD3, PRL
4mdma32 9.5MAOA, MAOB, HTR1A, TPH1, PRL, SLC6A3
5mcpp32 9.1HTR1A, HTR1B, HTR2A, HTR2C, HTR3A, PRL
65-hydroxytryptophan32 9.1TPH1, CRH, PRL, SLC6A4, HTR3A, HTR2A
7methysergide32 9 9 11.1MAOA, HTR1A, HTR1B, HTR1D, HTR2A, HTR2C
8metergoline32 9.0HTR1B, HTR1D, HTR2A, HTR2C, HTR3A, PRL
9paliperidone32 9 9 11.0HTR1A, HTR1D, HTR2A, HTR2C, DRD2, DRD3
10ipsapirone32 9.0HTR1A, HTR1B, HTR1D, HTR2A, HTR2C, HTR3A
11yohimbine32 9 9 11.0HTR1A, HTR1D, HTR2C, DRD2, DRD3, CRH
12ritanserin32 8.8PRL, HTR1A, HTR1B, HTR1D, HTR2A, HTR2C
13lisuride32 9 9 10.8HTR1A, HTR1B, HTR1D, HTR2A, HTR2C, DRD2
14venlafaxine32 34 9 18 9 12.8BDNF, HTR1A, HTR1B, HTR2A, HTR3A, TPH2
15homovanillic acid32 18 9.8PRL, SLC6A4, COMT, CRH, TPH1, BDNF
16m-chlorophenylpiperazine32 8.8HTR1A, HTR2A, HTR2C, HTR3A, PRL, SLC6A4
17sulpiride32 9 9 10.8PRL, DRD2, DRD4, CRH, SLC6A3, DRD3
18cabergoline32 9 9 10.7HTR1A, HTR1B, HTR1D, HTR2A, HTR2C, DRD2
19pergolide32 9 9 10.7DRD2, DRD3, DRD4, COMT, PRL, HTR2C
205-hydroxyindoleacetic acid32 18 9.7CRH, TPH1, ALDH2, HTR3A, MAOB, MAOA
21fluvoxamine32 34 9 9 11.6BDNF, MAOA, HTR1A, HTR2A, HTR3A, TPH1
22mirtazapine32 34 9 9 11.6CRH, SLC6A4, TPH2, PRL, HTR3A, HTR2C
23ropinirole32 9 9 10.6HTR2A, HTR2C, DRD2, DRD3, DRD4, COMT
24mhpg32 8.6COMT, PRL, SLC6A4, CRH, DRD4, MAOB
25paroxetine32 34 9 9 11.6MAOA, HTR1A, HTR1B, HTR2A, HTR3A, TPH1
26fenfluramine32 9 9 10.6HTR1A, HTR1B, HTR2A, HTR2C, HTR3A, TPH1
27clomipramine32 34 9 9 11.6MAOA, HTR1A, HTR2A, HTR2C, HTR3A, CRH
28methamphetamine32 9 9 10.5COMT, SLC6A3, DRD4, DRD3, DRD2, MAOA
29amine32 8.5MAOA, MAOB, HTR1B, HTR1D, HTR2C, HTR3A
30sertraline32 34 9 18 9 12.4SLC6A4, SLC6A3, CRH, HTR3A, HTR1A, MAOB
31ketanserin32 8.4BDNF, HTR1A, HTR1B, HTR1D, HTR2A, HTR2C
32imipramine32 34 9 18 9 12.4DRD3, SLC6A3, SLC6A4, HTR3A, HTR2A, HTR1A
33aripiprazole32 34 9 18 9 12.4HTR1D, HTR2A, HTR2C, HTR3A, DRD2, DRD3
34ziprasidone32 9 9 10.4DRD2, DRD3, DRD4, PRL, HTR3A, HTR2C
35apomorphine32 9 9 10.2MAOB, HTR1A, HTR1B, HTR1D, HTR2A, HTR2C
36levodopa32 9 9 10.1BDNF, MAOA, MAOB, HTR1A, HTR1B, TPH1
37pramipexole32 9 9 10.0SLC6A3, PRL, BDNF, HTR1A, HTR1B, HTR1D
38haloperidol32 34 9 9 11.0SLC6A3, SLC6A4, PRL, DRD4, BDNF, MAOB
39cocaine32 9 9 9.9BDNF, MAOB, HTR1B, HTR2C, DRD2, DRD3
40clozapine32 34 9 9 10.7DRD3, DRD4, CRP, PRL, SLC6A3, SLC6A4
41quetiapine32 9 18 9 10.7DRD4, PRL, SLC6A3, DRD3, DRD2, HTR3A
42citalopram32 34 9 18 9 11.7BDNF, MAOA, MAOB, HTR1A, HTR2A, HTR2C
43maoa32 7.6BDNF, MAOA, MAOB, HTR1A, HTR1B, HTR2A
44risperidone32 34 9 18 9 11.6PRL, SLC6A3, SLC6A4, BDNF, HTR1A, HTR1D
45gaba32 42 8.6BDNF, MAOA, MAOB, HTR2C, HTR3A, TPH1
46olanzapine32 34 9 18 9 11.6HTR2C, HTR3A, DRD2, DRD3, DRD4, COMT
475-hydroxytryptamine32 7.0COMT, PRL, SLC6A3, SLC6A4, CRH, DRD4
48fluoxetine32 34 9 9 9.9CRH, PRL, SLC6A3, SLC6A4, BDNF, TPH1
49dopamine32 9 18 9 8.8BDNF, COMT, PRL, SLC6A3, SLC6A4, CRH
50norepinephrine32 9 18 9 7.9BDNF, COMT, PRL, SLC6A3, SLC6A4, CRP

GO Terms for genes affiliated with Personality Disorder

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12Gene Ontology
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Cellular components related to personality disorder according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058877.7HTR1A, SLC6A4, SLC6A3, RXFP3, DRD4, DRD3
2plasma membraneGO:0058867.1DRD4, SNAP25, RXFP3, COMT, SLC6A3, DRD3

Biological processes related to personality disorder according to GeneDecks:

(show all 42)
idNameGO IDScoreTop Affiliating Genes
1serotonin biosynthetic processGO:04242710.4TPH1, TPH2
2dopamine catabolic processGO:04242010.4MAOA, COMT, SLC6A3
3negative regulation of dopamine receptor signaling pathwayGO:06016010.4DRD2, DRD3
4positive regulation of dopamine uptake involved in synaptic transmissionGO:05158610.4DRD2, DRD4
5negative regulation of synaptic transmission, glutamatergicGO:05196710.4HTR1B, HTR2A, DRD2
6regulation of dopamine uptake involved in synaptic transmissionGO:05158410.3DRD3, DRD2
7aromatic amino acid family metabolic processGO:00907210.3TPH2, TPH1
8regulation of cAMP metabolic processGO:03081410.3DRD3, DRD2
9indolalkylamine biosynthetic processGO:04621910.3TPH2, TPH1
10G-protein coupled receptor internalizationGO:00203110.3DRD3, DRD2, HTR1B
11behavioral response to ethanolGO:04814910.3DRD4, DRD2
12prepulse inhibitionGO:06013410.3SLC6A3, DRD3, DRD2
13response to histamineGO:03477610.3DRD2, DRD3, DRD4
14adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.2DRD4, DRD3, DRD2
15behavioral response to cocaineGO:04814810.2DRD2, DRD3, DRD4
16negative regulation of protein secretionGO:05070910.2DRD4, DRD3, DRD2
17dopamine metabolic processGO:04241710.2DRD4, DRD3, DRD2
18adenohypophysis developmentGO:02198410.2SLC6A3, DRD2
19arachidonic acid secretionGO:05048210.2DRD2, DRD3, DRD4
20regulation of dopamine metabolic processGO:04205310.2SLC6A3, DRD4
21negative regulation of adenylate cyclase activityGO:00719410.2DRD4, DRD3, DRD2
22response to amphetamineGO:00197510.2DRD4, DRD3, DRD2
23regulation of dopamine secretionGO:01405910.2HTR1B, HTR2A, DRD2, DRD3
24monoamine transportGO:01584410.2SLC6A4, SLC6A3
25social behaviorGO:03517610.2DRD3, DRD4, SLC6A4
26neurotransmitter biosynthetic processGO:04213610.1SLC6A3, COMT, ALDH2, MAOA
27release of sequestered calcium ion into cytosolGO:05120910.1HTR2A, HTR2C, DRD2
28long-term memoryGO:0076169.9DRD2, SNAP25, CRH
29locomotory behaviorGO:0076269.9DRD2, DRD3, SLC6A3
30fear responseGO:0425969.9DRD4, BDNF
31synaptic transmission, dopaminergicGO:0019639.9CRH, DRD4, DRD3, DRD2
32serotonin receptor signaling pathwayGO:0072109.9HTR3A, HTR2C, HTR2A
33neurotransmitter catabolic processGO:0421359.9MAOA, COMT
34xenobiotic metabolic processGO:0068059.8COMT, ALDH2, MAOB, MAOA
35response to cocaineGO:0422209.7SLC6A3, DRD3, DRD2, HTR3A, HTR1B
36response to toxinGO:0096369.7SLC6A4, DRD2, HTR1D, MAOB, SCN9A
37learning or memoryGO:0076119.7CRH, DRD3, BDNF
38response to ethanolGO:0454719.5BGLAP, MAOB, HTR1B, DRD3, SLC6A3
39feeding behaviorGO:0076319.5CRH, DRD2, HTR2C, BDNF
40negative regulation of lipid storageGO:0108889.0CRP, IL6
41synaptic transmissionGO:0072688.1SNAP25, CRH, COMT, SLC6A3, ALDH2, HTR3A
42response to drugGO:0424938.0BGLAP, SLC6A4, SLC6A3, COMT, DRD3, DRD2

Molecular functions related to personality disorder according to GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1monoamine transmembrane transporter activityGO:00850410.2SLC6A3, SLC6A4
2tryptophan 5-monooxygenase activityGO:00451010.1TPH1, TPH2
3dopamine receptor activity, coupled via Gi/GoGO:0015919.9DRD4, DRD3, DRD2
41-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine bindingGO:0718869.9HTR2A, HTR2C
5primary amine oxidase activityGO:0081319.8MAOA, MAOB
6dopamine bindingGO:0352409.8DRD2, DRD3, DRD4, SLC6A3
7serotonin receptor activityGO:0049939.0HTR3A, HTR2C, HTR2A, HTR1D, HTR1B, HTR1A
8drug bindingGO:0081448.9SLC6A3, DRD4, DRD3, DRD2, HTR2C, HTR2A
9serotonin bindingGO:0513788.9MAOA, HTR3A, HTR2C, HTR2A, HTR1D, HTR1B

Sources for Personality Disorder

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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