Aliases & Classifications for Personality Disorder

Aliases & Descriptions for Personality Disorder:

Name: Personality Disorder 12 29 14
Personality Disorders 52 41 69
Character Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1510
ICD9CM 35 301.8 301.89
ICD10 33 F60 F60.9
UMLS 69 C0029707

Summaries for Personality Disorder

MedlinePlus : 41 personality disorders are a group of mental illnesses. they involve long-term patterns of thoughts and behaviors that are unhealthy and inflexible. the behaviors cause serious problems with relationships and work. people with personality disorders have trouble dealing with everyday stresses and problems. they often have stormy relationships with other people. the cause of personality disorders is unknown. however, genes and childhood experiences may play a role. the symptoms of each personality disorder are different. they can mild or severe. people with personality disorders may have trouble realizing that they have a problem. to them, their thoughts are normal, and they often blame others for their problems. they may try to get help because of their problems with relationships and work. treatment usually includes talk therapy and sometimes medicine.

MalaCards based summary : Personality Disorder, also known as personality disorders, is related to antisocial personality disorder and schizoid personality disorder, and has symptoms including fatigue, sleep disturbances and photophobia. An important gene associated with Personality Disorder is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are Peptide ligand-binding receptors and Transmission across Chemical Synapses. The drugs Citalopram and Fluoxetine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and amygdala, and related phenotypes are shRNA abundance <= 50% and behavior/neurological

Disease Ontology : 12 A disease of mental health that involve long-term patterns of thoughts and behaviors that cause serious problems with relationships and work.

Wikipedia : 71 Personality disorders (PD) are a class of mental disorders characterized by enduring maladaptive... more...

Related Diseases for Personality Disorder

Diseases in the Personality Disorder family:

Multiple Personality Disorder

Diseases related to Personality Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 179)
id Related Disease Score Top Affiliating Genes
1 antisocial personality disorder 34.0 HTR1A HTR2A
2 schizoid personality disorder 33.5 DRD3 SLC6A4
3 multiple personality disorder 32.7 COMT HTR1A HTR1B HTR2A HTR2C MAOA
4 dissociative disorder 29.7 DRD4 MAOA MAOB
5 hypoglycemia 28.7 ANKK1 DRD2 DRD3 SLC6A4
6 alopecia 28.1 ALDH2 ANKK1 DRD2 DRD3 DRD4 SLC6A4
7 schizophrenia 27.9 ANKK1 COMT DRD2 DRD3 DRD4 HTR1A
8 borderline personality disorder 12.4
9 avoidant personality disorder 12.4
10 obsessive-compulsive personality disorder 12.4
11 dependent personality disorder 12.3
12 histrionic personality disorder 12.3
13 paranoid personality disorder 12.3
14 schizotypal personality disorder 12.3
15 narcissistic personality disorder 12.3
16 intermittent explosive disorder 11.5
17 cyclothymic disorder 10.8
18 conduct disorder 10.8
19 sexual sadism 10.7
20 impulse control disorder 10.5
21 ceroid lipofuscinosis, neuronal, 7 10.3
22 ceroid lipofuscinosis, neuronal, 8 10.3
23 velocardiofacial syndrome 10.3
24 conversion disorder 10.3
25 dissociative seizures 10.3
26 gardner-diamond syndrome 10.3
27 polyneuropathy 10.2 HTR1A HTR2A
28 nephronophthisis 13 10.2 COMT HTR2A SLC6A4
29 neurogenic bladder 10.2 HTR2A MAOA SLC6A4
30 adult brainstem astrocytoma 10.2 HTR1A MAOA SLC6A4
31 kidney pelvis papillary carcinoma 10.2 HTR1A MAOA SLC6A4
32 conjunctival pigmentation 10.2 MAOA MAOB SLC6A4
33 cholestasis-lymphedema syndrome 10.2 COMT MAOA
34 aryepiglottic fold cancer 10.2 HTR1A HTR2A
35 lethal congenital contracture syndrome 1 10.2 COMT MAOA MAOB
36 ornithosis 10.2 DRD2 MAOA SLC6A4
37 social phobia 10.2
38 euthyroid sick syndrome 10.2 DRD2 HTR2A SLC6A4
39 chronic eosinophilic pneumonia 10.2 COMT HTR1A MAOA SLC6A4
40 hemolytic anemia, cd59-mediated, with or without immune-mediated polyneuropathy 10.2 COMT HTR2A SLC6A4
41 allergic hypersensitivity disease 10.1 DRD2 HTR1A HTR2A
42 vascular cancer 10.1 DRD2 HTR1A HTR2A
43 intracranial cavernous angioma 10.1 DRD2 SLC6A3 SLC6A4
44 rhinoscleroma 10.1 COMT DRD2
45 myopathy, distal, with early respiratory failure, autosomal dominant 10.1 COMT SLC6A3 TPH1
46 chagas disease 10.1 COMT HTR1B HTR2A SLC6A4
47 obsessive-compulsive disorder 10.1
48 tinea pedis 10.1 HTR1A MAOA SLC6A3 SLC6A4
49 anxiety disorder 10.1
50 substance dependence 10.1

Comorbidity relations with Personality Disorder via Phenotypic Disease Network (PDN): (show all 13)


Acute Cystitis Alzheimer Disease
Anxiety Disorder Deficiency Anemia
Dependent Personality Disorder Dysthymic Disorder
Generalized Anxiety Disorder Heart Disease
Hypertension, Essential Hypothyroidism
Parkinson Disease, Late-Onset Protein-Energy Malnutrition
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Personality Disorder:



Diseases related to Personality Disorder

Symptoms & Phenotypes for Personality Disorder

UMLS symptoms related to Personality Disorder:


fatigue, sleep disturbances, photophobia, personality changes, restlessness, pseudobulbar behavioral symptoms

GenomeRNAi Phenotypes related to Personality Disorder according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 shRNA abundance <= 50% GR00343-S 9.32 ALDH2 ANKK1 COMT DRD2 DRD3 DRD4

MGI Mouse Phenotypes related to Personality Disorder:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.24 ALDH2 COMT DRD2 DRD3 DRD4 HTR1A
2 homeostasis/metabolism MP:0005376 10.07 ALDH2 COMT DRD2 DRD3 DRD4 HTR1A
3 cardiovascular system MP:0005385 9.97 MAOA SLC6A4 TPH1 TPH2 COMT DRD2
4 integument MP:0010771 9.7 ALDH2 DRD2 HTR2C SLC6A3 SLC6A4 TPH1
5 muscle MP:0005369 9.5 DRD2 HTR1B HTR2A HTR2C SLC6A3 SLC6A4
6 nervous system MP:0003631 9.4 COMT DRD2 DRD3 DRD4 HTR1A HTR2C

Drugs & Therapeutics for Personality Disorder

Drugs for Personality Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 318)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Citalopram Approved Phase 4,Phase 3,Phase 2 59729-33-8 2771
2
Fluoxetine Approved, Vet_approved Phase 4,Phase 3,Phase 2 54910-89-3 3386
3
Fluvoxamine Approved, Investigational Phase 4,Phase 3 54739-18-3 3404 5324346
4
Topiramate Approved Phase 4,Phase 3 97240-79-4 5284627
5
Paroxetine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61869-08-7 43815
6
Sertraline Approved Phase 4,Phase 3,Phase 2,Phase 1 79617-96-2 68617
7
Norepinephrine Approved Phase 4,Phase 3,Phase 2 51-41-2 439260
8
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
9
Risperidone Approved, Investigational Phase 4,Phase 1,Phase 2 106266-06-2 5073
10
Cycloserine Approved Phase 4,Phase 3,Phase 2 68-41-7 401 6234
11
Methylphenidate Approved, Investigational Phase 4,Phase 2,Phase 3 113-45-1 4158
12
Clomipramine Approved, Vet_approved Phase 4,Phase 3,Phase 2 303-49-1 2801
13
Ethanol Approved Phase 4,Phase 2,Phase 3 64-17-5 702
14
Guanfacine Approved, Investigational Phase 4,Phase 2 29110-47-2 3519
15
Lamotrigine Approved, Investigational Phase 4,Phase 2 84057-84-1 3878
16
Ondansetron Approved Phase 4,Phase 2 99614-02-5 4595
17
Olanzapine Approved, Investigational Phase 4,Phase 3 132539-06-1 4585
18
Haloperidol Approved Phase 4 52-86-8 3559
19
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
20
Liraglutide Approved Phase 4 204656-20-2
21
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
22
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 16590-41-3 5360515
23
Propranolol Approved, Investigational Phase 4 525-66-6 4946
24
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
25
Methyltestosterone Approved Phase 4 58-18-4 6010
26
Testosterone Approved, Investigational Phase 4 58-22-0 6013
27
Mirabegron Approved Phase 4 223673-61-8
28
Heroin Approved, Illicit Phase 4 561-27-3 5462328
29
Naratriptan Approved, Investigational Phase 4 143388-64-1, 121679-13-8 4440
30
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
31
Maleic acid Experimental Phase 4,Phase 3 110-16-7 444266
32 Antidepressive Agents Phase 4,Phase 3,Phase 2,Phase 1
33 Antidepressive Agents, Second-Generation Phase 4,Phase 3,Phase 2,Phase 1
34 Antiparkinson Agents Phase 4,Phase 3,Phase 2,Phase 1
35 Autonomic Agents Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
36 Cholinergic Agents Phase 4,Phase 3,Phase 1,Phase 2
37 Cholinergic Antagonists Phase 4,Phase 3,Phase 2
38 Cytochrome P-450 CYP2D6 Inhibitors Phase 4,Phase 3,Phase 2
39 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2
40 Muscarinic Antagonists Phase 4,Phase 3,Phase 2
41 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
42 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
43 Parasympatholytics Phase 4,Phase 3,Phase 2
44 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
45 Psychotropic Drugs Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
46
Serotonin Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-67-9 5202
47 Serotonin Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
48 Serotonin Uptake Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
49 Anti-Anxiety Agents Phase 4,Phase 3,Phase 2,Phase 1
50 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 771)
id Name Status NCT ID Phase
1 Efficacy of Omega-3 Fatty Acids on Borderline Personality Disorder Unknown status NCT00437099 Phase 4
2 Comparing Treatments for Self-Injury and Suicidal Behavior in People With Borderline Personality Disorder Unknown status NCT00834834 Phase 4
3 Cost-Effectiveness of Adding Web-Based Cognitive-Behavioral Therapy (CBT) to Luvox CR for Obsessive Compulsive Disorder (OCD) Unknown status NCT00743834 Phase 4
4 Reduction of Cardiovascular Risk in Severe Mental Illness Unknown status NCT01182012 Phase 4
5 Topiramate Augmentation in the Treatment of Obsessive-Compulsive Disorder Unknown status NCT00211744 Phase 4
6 Treatment Youth With Obsessive-Compulsive Disorder Unknown status NCT00708240 Phase 4
7 The Effect of Quetiapine XR in Depressive Patients Showing Aberrant N100 Amplitude Slope Unknown status NCT01357967 Phase 4
8 Desvenlafaxine vs. Placebo Treatment of Chronic Depression Unknown status NCT01537068 Phase 4
9 Study of Lamotrigine Treatment of Affective Instability in Borderline Personality Disorder Completed NCT00634062 Phase 4
10 Treating Suicidal Behavior and Self-Mutilation in People With Borderline Personality Disorder Completed NCT00533117 Phase 4
11 Effective Measurement of Risperidone Treatment Outcome for Persons With Borderline Personality Disorder Completed NCT00204347 Phase 4
12 Effects of Comorbid Personality Disorder on the Treatment of Bipolar I Disorder Completed NCT00178061 Phase 4
13 Augmentation in Tx-resistant OCD: an Open Label Trial Completed NCT00590642 Phase 4
14 D-Cycloserine as an Adjunct to Internet-CBT for OCD Completed NCT01649895 Phase 4
15 Methylphenidate Hydrochloride Controlled-Release Tablets Augmentation Strategy for Patients With Obsessive Compulsive Disorder Completed NCT02194075 Phase 4
16 Ondansetron Augmentation in Treatment-resistant OCD Completed NCT01303536 Phase 4
17 Ondansetron in Treatment Resistant Obsessive Compulsive Disorder (OCD) Completed NCT00796497 Phase 4
18 Escitalopram for the Treatment of Obsessive Compulsive Disorder (OCD) Completed NCT00116532 Phase 4
19 Effectiveness and Safety of Atypical Antipsychotic Agents in Augmenting SSRI-Refractory Obsessive-Compulsive Disorder Completed NCT00854919 Phase 4
20 Treatment of Obsessive-Compulsive Disorder Completed NCT00000373 Phase 4
21 Duloxetine for the Treatment of Obsessive Compulsive Disorder (OCD) Completed NCT00464698 Phase 4
22 Quetiapine Augmentation Versus Clomipramine Augmentation of SSRI for Obsessive-Compulsive Disorder Patients Completed NCT00564564 Phase 4
23 Using Drug Augmentation to Treat Obsessive Compulsive Disorder Patients Who Did Not Respond to Previous Treatment Completed NCT00466609 Phase 4
24 Deep Brain Stimulation for Obsessive Compulsive Disorder (OCD PMCF) Completed NCT01135745 Phase 4
25 Effectiveness of Sertraline and Cognitive Behavioral Therapy in Treating Pediatric Obsessive-Compulsive Disorder Completed NCT00382291 Phase 4
26 Group Cognitive Behavioral Therapy Versus Fluoxetine for Obsessive-Compulsive Disorder: a Practical Trial Completed NCT00680602 Phase 4
27 Comparison of Effects Between Conventional Dose and High Dose Escitalopram on Clinical Improvement in Patients With Obsessive-compulsive Disorder Completed NCT00723060 Phase 4
28 Multimodal Treatment Study of Children With Attention Deficit and Hyperactivity Disorder (MTA) Completed NCT00000388 Phase 4
29 Antidepressant Safety in Kids Study Completed NCT00395213 Phase 4
30 Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated With Streptococcal Infections Completed NCT00001658 Phase 4
31 Trial of Seroquel SR for Alcohol Dependence and Comorbid Anxiety Completed NCT00352469 Phase 4
32 Treatments for Psychogenic Nonepileptic Seizures (NES) Completed NCT00159965 Phase 4
33 Treatment Trial for Psychogenic Nonepileptic Seizures Completed NCT00835627 Phase 4
34 Influence of Appetite Related Hormones in Binge Eating Behaviour Among the Overweight and Obese Completed NCT01739049 Phase 4
35 Comparison of the Effects of Aripiprazole and Risperidone on the Pattern of Brain Activation in Schizophrenic Patients Completed NCT01109147 Phase 4
36 Randomized Controlled Trial on the Treatment Effects of Melatonin and Light Therapy on Delayed Sleep Phase Syndrome Completed NCT00834886 Phase 4
37 Depression: The Search for Treatment-Relevant Phenotypes-Pilot Study Completed NCT00222820 Phase 4
38 Attaining and Maintaining Wellness in Obsessive-compulsive Disorder Recruiting NCT01686087 Phase 4
39 Fear Conditioned Response in Healthy Subjects and in OCD Patients Pre and Post Treatment With Sertraline. Recruiting NCT03068429 Phase 4
40 Brief Intervention for OCD Fears Recruiting NCT02790710 Phase 4
41 Efficacy of Adding Topiramate to Current Treatment in Refractory Obsessive Compulsive Disorder (OCD) Recruiting NCT00182520 Phase 4
42 Probiotic Treatment in Adult Obsessive-Compulsive Disorder Recruiting NCT02334644 Phase 4
43 A Study of Pregabalin (Lyrica) Augmentation in Serotonin Reuptake Inhibitor-Refractory Obsessive Compulsive Disorder Recruiting NCT00994786 Phase 4
44 Translational Approach to the Understanding and Treatment of Obsessive-Compulsive Disorder (OCD). Can D-Cycloserine Enhance and Stabilize the Treatment-response in Relapsed and Non-responding OCD-patients? Recruiting NCT02656342 Phase 4
45 Efficacy of Exposure and Response Prevention(ERP) and SSRIs in Chinese OCD Patients Recruiting NCT02022709 Phase 4
46 Physiological and Psychological Effects of Testosterone During Severe Energy Deficit and Recovery Recruiting NCT02734238 Phase 4
47 Comparisons of the Effects of Solifenacin Versus Mirabegron on Autonomic System, Arterial Stiffness and Psychosomatic Distress and Clinical Outcomes Recruiting NCT02540707 Phase 4
48 Sertraline in Generalized Social Phobia With Co-Occurring Anxiety and Mood Disorders Active, not recruiting NCT00182533 Phase 4
49 Developing New Clinical Management Strategies Active, not recruiting NCT02082392 Phase 4
50 Biomarkers of Injectable Extended Release Naltrexone Treatment Enrolling by invitation NCT02324725 Phase 4

Search NIH Clinical Center for Personality Disorder

Genetic Tests for Personality Disorder

Genetic tests related to Personality Disorder:

id Genetic test Affiliating Genes
1 Personality Disorder 29

Anatomical Context for Personality Disorder

MalaCards organs/tissues related to Personality Disorder:

39
Brain, Testes, Amygdala, Eye, Cortex, Temporal Lobe, Caudate Nucleus

Publications for Personality Disorder

Articles related to Personality Disorder:

(show top 50) (show all 2056)
id Title Authors Year
1
The specificity of emotion dysregulation in adolescents with borderline personality disorder: comparison with psychiatric and healthy controls. ( 28078089 )
2017
2
PDTRT Special Section: Methodological issues in personality disorder research. ( 28045301 )
2017
3
Altered Empathy for Psychological and Physical Pain in Borderline Personality Disorder. ( 28072040 )
2017
4
Compelled to Risk: Does Sexual Compulsivity Explain the Connection Between Borderline Personality Disorder Features and Number of Sexual Partners? ( 28072043 )
2017
5
Narcissistic Personality Disorder and suicidal behavior in mood disorders. ( 27816770 )
2017
6
Using online, crowdsourcing platforms for data collection in personality disorder research: The example of Amazon's Mechanical Turk. ( 28045305 )
2017
7
Cognitive behavioral therapy for posttraumatic stress disorder in individuals with severe mental illness and borderline personality disorder. ( 28086181 )
2017
8
Personality disorders and pathological gambling. ( 27798487 )
2017
9
Treatment outcomes for inpatients with obsessive-compulsive personality disorder: An open comparison trial. ( 27988411 )
2017
10
A Mother's Borderline Personality Disorder and Her Sensitivity, Autonomy Support, Hostility, Fearful/Disoriented Behavior, and Role Reversal With Her Young Child. ( 28072039 )
2017
11
Insomnia in adult attention-deficit/hyperactivity disorder: A comparison with borderline personality disorder population in a clinical setting and control participants. ( 28501733 )
2017
12
Predicting Nonsuicidal Self-Injury in Borderline Personality Disorder Using Ecological Momentary Assessment. ( 28072044 )
2017
13
The current state and future of factor analysis in personality disorder research. ( 28045304 )
2017
14
The Reality of Recovery in Personality Disorder, By Heather Castillo. ( 28084097 )
2017
15
Resting cardiac function in adolescent non-suicidal self-injury: The impact of borderline personality disorder symptoms and psychosocial functioning. ( 28039803 )
2017
16
Interpersonal Threat Sensitivity in Borderline Personality Disorder: An Eye-Tracking Study. ( 28072041 )
2017
17
Using personality neuroscience to study personality disorder. ( 28045302 )
2017
18
Comorbidity study of borderline personality disorder: applying association rule mining to the Taiwan national health insurance research database. ( 28077135 )
2017
19
Did you get any help? A post-hoc secondary analysis of a randomized controlled trial of psychoeducation for patients with antisocial personality disorder in outpatient substance abuse treatment programs. ( 28068951 )
2017
20
Obsessive compulsive personality disorder in Progressive Supranuclear Palsy, Multiple System Atrophy and Essential Tremor. ( 27364040 )
2016
21
Neurocognitive Deficits Associated with Antisocial Personality Disorder in Non-treatment-seeking Young Adults. ( 27236178 )
2016
22
Integrating Early Intervention for Borderline Personality Disorder and Mood Disorders. ( 27144298 )
2016
23
Cognitive and affective processing of social exclusion in borderline personality disorder and social anxiety disorder. ( 27616717 )
2016
24
Creativity and borderline personality disorder: evidence from a voxel-based morphometry study. ( 27174566 )
2016
25
A Neurobiological Model of Borderline Personality Disorder: Systematic and Integrative Review. ( 27603741 )
2016
26
Evidence-Based Treatments for Borderline Personality Disorder: Implementation, Integration, and Stepped Care. ( 27603742 )
2016
27
Long-Term Course of Borderline Personality Disorder. ( 27603806 )
2016
28
Genome-wide association study of antisocial personality disorder. ( 27598967 )
2016
29
Deficient amygdala-prefrontal intrinsic connectivity after effortful emotion regulation in borderline personality disorder. ( 28039553 )
2016
30
Borderline Personality Disorder and the Effects of Instructed Emotional Avoidance or Acceptance in Daily Life. ( 27617652 )
2016
31
Borderline Personality Disorder Symptoms in College Students: The Complex Interplay between Alexithymia, Emotional Dysregulation and Rumination. ( 27348858 )
2016
32
Modulatory effects of psychopathy on Wisconsin Card Sorting Test performance in male offenders with Antisocial Personality Disorder. ( 26708441 )
2016
33
Psychopathy, Antisocial Personality Disorder, and Reconviction in an Australian Sample of Forensic Patients. ( 27288398 )
2016
34
OBSESSIVE-COMPULSIVE PERSONALITY DISORDER: EVIDENCE FOR TWO DIMENSIONS. ( 26594839 )
2016
35
Facial emotion perception impairments in schizophrenia patients with comorbid antisocial personality disorder. ( 26778631 )
2016
36
Association of ventral striatum monoamine oxidase-A binding and functional connectivity in antisocial personality disorder with high impulsivity: A positron emission tomography and functional magnetic resonance imaging study. ( 26908392 )
2016
37
Comparing the experience of voices in borderline personality disorder with the experience of voices in a psychotic disorder: A systematic review. ( 26912339 )
2016
38
Biting the hand that feeds: current opinion on the interpersonal causes, correlates, and consequences of borderline personality disorder. ( 27990277 )
2016
39
The role of hypothalamus-pituitary-adrenal genes and childhood trauma in borderline personality disorder. ( 26182893 )
2016
40
Sleep Problems in Childhood and Borderline Personality Disorder Symptoms in Early Adolescence. ( 27108717 )
2016
41
Association between schizotypal and borderline personality disorder traits, and cannabis use in young adults. ( 27149691 )
2016
42
A Comparison of Psychoanalytic Therapy and Cognitive Behavioral Therapy for Anxiety (Panic/Agoraphobia) and Personality Disorders (APD Study): Presentation of the RCT Study Design. ( 27594602 )
2016
43
Alcohol Craving and Consumption in Borderline Personality Disorder: When, Where, and with Whom. ( 28042520 )
2016
44
Comparison of cognitive flexibility and planning ability in patients with obsessive compulsive disorder, patients with obsessive compulsive personality disorder, and healthy controls. ( 27688641 )
2016
45
The Impact of Obsessive Compulsive Personality Disorder on Cognitive Behaviour Therapy for Obsessive Compulsive Disorder. ( 27246860 )
2016
46
Influence of Psychiatric and Personality Disorders on Smoking Cessation Among Individuals in Opiate Dependence Treatment. ( 27064523 )
2016
47
Demystifying Complexes, Transference, and Narcissistic Personality Disorder with Jung and Lacan. ( 27335529 )
2016
48
Skills use and common treatment processes in dialectical behaviour therapy for borderline personality disorder. ( 27132175 )
2016
49
An Investigation into the Roles of Theory of Mind, Emotion Regulation, and Attachment Styles in Predicting the Traits of Borderline Personality Disorder. ( 28050180 )
2016
50
Paroxetine, Cognitive Therapy or Their Combination in the Treatment of Social Anxiety Disorder with and without Avoidant Personality Disorder: A Randomized Clinical Trial. ( 27744447 )
2016

Variations for Personality Disorder

Expression for Personality Disorder

Search GEO for disease gene expression data for Personality Disorder.

Pathways for Personality Disorder

Pathways related to Personality Disorder according to GeneCards Suite gene sharing:

(show all 24)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.43 DRD2 DRD3 DRD4 HTR1A HTR1B HTR2A
2
Show member pathways
12.86 ALDH2 COMT MAOA SLC6A3 SLC6A4
3
Show member pathways
12.64 COMT DRD2 DRD3 DRD4 MAOA MAOB
4 12.4 COMT HTR1A TPH1 TPH2
6
Show member pathways
12.14 ALDH2 MAOA MAOB TPH1 TPH2
7 12.06 HTR1A HTR2A MAOA SLC6A4 TPH1 TPH2
8
Show member pathways
11.91 DRD2 MAOA MAOB SLC6A3
9 11.77 DRD3 DRD4 HTR2A
10
Show member pathways
11.76 DRD2 DRD3 DRD4
11
Show member pathways
11.76 DRD2 DRD3 DRD4 HTR1A HTR1B HTR2A
12 11.66 HTR1A HTR1B HTR2A HTR2C MAOA MAOB
13
Show member pathways
11.62 COMT MAOA MAOB
14
Show member pathways
11.49 ALDH2 MAOA MAOB
15
Show member pathways
11.39 MAOA SLC6A3 SLC6A4 TPH2
16
Show member pathways
11.27 ALDH2 MAOA MAOB
17
Show member pathways
11.09 ALDH2 COMT MAOA SLC6A3 SLC6A4
18
Show member pathways
11.04 COMT MAOA TPH1
19 11.02 DRD2 DRD3
20 10.9 HTR2A HTR2C
21 10.83 COMT MAOA MAOB
22
Show member pathways
10.77 ALDH2 MAOA MAOB
23
Show member pathways
10.77 ALDH2 COMT MAOA MAOB
24 10.67 HTR1A HTR1B HTR2A HTR2C MAOA SLC6A4

GO Terms for Personality Disorder

Cellular components related to Personality Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.73 COMT DRD2 DRD3 DRD4 HTR1A HTR1B
2 neuron projection GO:0043005 9.56 SLC6A3 SLC6A4 TPH1 TPH2
3 axon GO:0030424 9.46 COMT DRD2 HTR2A SLC6A3
4 integral component of plasma membrane GO:0005887 9.28 DRD2 DRD3 DRD4 HTR1A HTR1B HTR2A

Biological processes related to Personality Disorder according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
id Name GO ID Score Top Affiliating Genes
1 cellular calcium ion homeostasis GO:0006874 9.91 DRD3 DRD4 HTR2A HTR2C
2 response to toxic substance GO:0009636 9.9 DRD2 MAOB SLC6A4
3 locomotory behavior GO:0007626 9.9 DRD2 DRD3 HTR2C SLC6A3
4 circadian rhythm GO:0007623 9.88 SLC6A4 TPH1 TPH2
5 social behavior GO:0035176 9.86 DRD3 DRD4 SLC6A4
6 positive regulation of fat cell differentiation GO:0045600 9.85 HTR2A HTR2C TPH1
7 feeding behavior GO:0007631 9.85 DRD2 HTR1B HTR2C
8 release of sequestered calcium ion into cytosol GO:0051209 9.83 DRD2 HTR2A HTR2C
9 response to ethanol GO:0045471 9.83 DRD2 DRD3 HTR1B MAOB SLC6A3
10 behavioral fear response GO:0001662 9.81 DRD4 HTR1A HTR2C
11 negative regulation of adenylate cyclase activity GO:0007194 9.81 DRD2 DRD3 DRD4
12 response to amphetamine GO:0001975 9.79 DRD2 DRD3 DRD4
13 arachidonic acid secretion GO:0050482 9.79 DRD2 DRD3 DRD4
14 dopamine receptor signaling pathway GO:0007212 9.77 DRD2 DRD3 DRD4
15 vasoconstriction GO:0042310 9.76 HTR1A HTR1B SLC6A4
16 response to cocaine GO:0042220 9.76 DRD2 DRD3 HTR1B SLC6A3
17 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.75 DRD2 HTR1B HTR2A
18 prepulse inhibition GO:0060134 9.74 DRD2 DRD3 SLC6A3
19 temperature homeostasis GO:0001659 9.73 DRD2 HTR2A
20 response to iron ion GO:0010039 9.73 DRD2 SLC6A3
21 synaptic transmission, dopaminergic GO:0001963 9.73 DRD2 DRD3
22 negative regulation of cAMP biosynthetic process GO:0030818 9.73 DRD4 HTR1B
23 negative regulation of protein secretion GO:0050709 9.73 DRD2 DRD3 DRD4
24 positive regulation of kinase activity GO:0033674 9.72 DRD4 HTR2A
25 behavioral response to ethanol GO:0048149 9.72 DRD2 DRD4
26 neurotransmitter biosynthetic process GO:0042136 9.72 SLC6A3 SLC6A4
27 ammonium transmembrane transport GO:0072488 9.72 SLC6A3 SLC6A4
28 G-protein coupled receptor internalization GO:0002031 9.72 DRD2 DRD3 HTR1B
29 positive regulation of renal sodium excretion GO:0035815 9.71 DRD2 DRD3
30 negative regulation of voltage-gated calcium channel activity GO:1901386 9.71 DRD2 DRD4
31 bone remodeling GO:0046849 9.71 HTR1B TPH1
32 catecholamine metabolic process GO:0006584 9.71 COMT MAOA
33 neurotransmitter catabolic process GO:0042135 9.71 COMT MAOA MAOB
34 regulation of dopamine secretion GO:0014059 9.71 DRD2 DRD3 HTR1B HTR2A
35 adenohypophysis development GO:0021984 9.7 DRD2 SLC6A3
36 monoamine transport GO:0015844 9.7 SLC6A3 SLC6A4
37 aromatic amino acid family metabolic process GO:0009072 9.7 TPH1 TPH2
38 regulation of cAMP metabolic process GO:0030814 9.7 DRD2 DRD3
39 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.7 DRD2 DRD3 DRD4
40 regulation of hormone secretion GO:0046883 9.69 HTR1A HTR2A
41 dopamine uptake involved in synaptic transmission GO:0051583 9.69 SLC6A3 SLC6A4
42 indolalkylamine biosynthetic process GO:0046219 9.69 TPH1 TPH2
43 regulation of dopamine metabolic process GO:0042053 9.69 DRD4 HTR1A SLC6A3
44 regulation of dopamine uptake involved in synaptic transmission GO:0051584 9.68 DRD2 DRD3
45 negative regulation of serotonin secretion GO:0014063 9.67 HTR1B MAOB
46 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0007198 9.67 HTR1A HTR1B
47 positive regulation of phosphatidylinositol biosynthetic process GO:0010513 9.67 HTR2A HTR2C
48 regulation of behavior GO:0050795 9.67 HTR1A HTR1B HTR2A
49 negative regulation of dopamine receptor signaling pathway GO:0060160 9.65 DRD2 DRD3
50 positive regulation of dopamine uptake involved in synaptic transmission GO:0051586 9.65 DRD2 DRD4

Molecular functions related to Personality Disorder according to GeneCards Suite gene sharing:

(show all 18)
id Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.96 ALDH2 MAOA MAOB TPH1 TPH2
2 signal transducer activity GO:0004871 9.95 DRD2 DRD3 DRD4 HTR1A HTR1B HTR2A
3 G-protein coupled serotonin receptor activity GO:0004993 9.62 HTR1A HTR1B HTR2A HTR2C
4 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.61 DRD2 DRD3 DRD4
5 amino acid binding GO:0016597 9.58 TPH1 TPH2
6 neurotransmitter:sodium symporter activity GO:0005328 9.57 SLC6A3 SLC6A4
7 neurotransmitter receptor activity GO:0030594 9.56 HTR1A HTR1B HTR2A HTR2C
8 monoamine transmembrane transporter activity GO:0008504 9.55 SLC6A3 SLC6A4
9 primary amine oxidase activity GO:0008131 9.54 MAOA MAOB
10 dopamine neurotransmitter receptor activity GO:0004952 9.54 DRD2 DRD3 DRD4
11 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen GO:0016714 9.52 TPH1 TPH2
12 dopamine:sodium symporter activity GO:0005330 9.51 SLC6A3 SLC6A4
13 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding GO:0071886 9.49 HTR2A HTR2C
14 tryptophan 5-monooxygenase activity GO:0004510 9.48 TPH1 TPH2
15 dopamine binding GO:0035240 9.46 DRD2 DRD3 DRD4 SLC6A3
16 serotonin binding GO:0051378 9.26 HTR1A HTR1B HTR2A HTR2C
17 drug binding GO:0008144 9.17 DRD2 DRD3 DRD4 HTR1B HTR2A HTR2C
18 G-protein coupled receptor activity GO:0004930 10 DRD2 DRD3 DRD4 HTR1A HTR1B HTR2A

Sources for Personality Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
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34 ICD10 via Orphanet
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37 KEGG
38 LifeMap
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