MCID: PRT037
MIFTS: 61

Pertussis malady

Rare diseases, Infectious diseases, Respiratory diseases categories
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Summaries for Pertussis

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8Disease Ontology, 34MedlinePlus, 4CDC, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Whooping cough is an infectious bacterial disease that causes uncontrollable coughing. the name comes from the noise you make when you take a breath after you cough. you may have choking spells or may cough so hard that you vomit. anyone can get whooping cough, but it is more common in infants and children. it's especially dangerous for infants. the coughing spells can be so bad that it is hard for infants to eat, drink, or breathe. to make a diagnosis, your doctor may do a physical exam, blood tests, chest x-rays, or nose or throat cultures. before there was a vaccine, whooping cough was one of the most common childhood diseases and a major cause of childhood deaths in the u.s. now most cases are prevented by vaccines. if you have whooping cough, treatment with antibiotics may help if given early. centers for disease control and prevention

MalaCards: Pertussis, also known as whooping cough, is related to cholera and diphtheria. An important gene associated with Pertussis is CNR2 (cannabinoid receptor 2 (macrophage)), and among its related pathways are Neuropeptides signaling through G protein alpha i and G protein alpha q and LPA receptor mediated events. The drugs erythromycin pwdr and guaifenesin and the compounds nabilone and [3h]win55212-2 have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract, testes and t cells.

Disease Ontology:8 A commensal bacterial infectious disease that results in inflammation located in respiratory tract, has material basis in bordetella pertussis, or has material basis in bordetella parapertussis, which produce toxins that paralyze the cilia of the respiratory epithelial cells. the infection is characterized by a prolonged, high-pitched, deeply indrawn breath (whoop).

CDC:4 Pertussis, also known as whooping cough, is a highly contagious respiratory disease. It is caused by the bacterium Bordetella pertussis.

Wikipedia:65 Pertussis?commonly called whooping cough (/?wu?p??/, /?hu?p??/, or /?hwu?p?? k?f/)?is a highly... more...

Aliases & Classifications for Pertussis

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 35MeSH, 26ICD10 via Orphanet, 36MESH via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Respiratory diseases


Aliases & Descriptions:

pertussis 8 43 10 49 62
whooping cough 8 43 49 34
whooping cough due to unspecified organism 62
bordetella pertussis infection 43
bordetella infections 62
bordetella infection 8
wc - whooping cough 8


External Ids:

Disease Ontology8 DOID:1116
MeSH35 D001885
ICD10 via Orphanet26 A37.1, A37.0, A37.8 A37.9, more
MESH via Orphanet36 D014917
SNOMED-CT58 26484003
SNOMED-CT via Orphanet59 27836007
UMLS via Orphanet63 C0043167

Related Diseases for Pertussis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Pertussis:



Diseases related to pertussis

Symptoms for Pertussis

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Drugs & Therapeutics for Pertussis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Pertussis

Search NIH Clinical Center for Pertussis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Pertussis

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Anatomical Context for Pertussis

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33MalaCards, 14FMA
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MalaCards organs/tissues related to Pertussis:

33
Testes, T cells, Monocytes, Endothelial, Heart, Smooth muscle, Brain, Adipocyte, Lung, B cells, Pituitary, Trachea, Pancreatic islet, Ovary, Breast, Thymus, Lymph node, Whole blood

FMA organs/tissues related to Pertussis:

14
Respiratory tract

Animal Models for Pertussis or affiliated genes

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Publications for Pertussis

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52PubMed
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Articles related to Pertussis:

(show top 50)    (show all 965)
idTitleAuthorsYear
1
Health care worker exposures to pertussis: missed opportunities for prevention. (24344101)
2014
2
The "how" of polymerase chain reaction testing for Bordetella pertussis depends on the "why". (23087394)
2013
3
Combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Hemophilus influenzae type b vaccine; Infanrixa8c hexa: Twelve years of experience in Italy. (24004825)
2013
4
Identification of biomarkers to detect residual pertussis toxin using microarray analysis of dendritic cells. (24055089)
2013
5
Attitudes, knowledge and perceptions towards whooping cough and pertussis vaccine in hospitalized adults. (24370707)
2013
6
A proteoliposome formulation derived from Bordetella pertussis induces protection in two murine challenge models. (23458724)
2013
7
Prevalence and molecular characterization of pertactin-deficient Bordetella pertussis in the US. (24256623)
2013
8
Bordetella holmesii and pertussis diagnosis: authors' reply. (23842047)
2013
9
Attitude of Italian physicians toward pertussis diagnosis. (23732898)
2013
10
Cost-effectiveness analysis of a pertussis vaccination programme for Japan considering intergenerational infection. (23570987)
2013
11
Tdap vaccination during pregnancy to reduce pertussis infection in young infants. (23673584)
2013
12
Genome Sequences of 28 Bordetella pertussis U.S. Outbreak Strains Dating from 2010 to 2012. (24356839)
2013
13
Pertussis vaccination of health care workers: ACOEM medical center occupational health section task force on pertussis vaccination of health care workers. (24013658)
2013
14
Randomized, controlled, multicenter study of the immunogenicity and safety of a fully liquid combination diphtheria-tetanus toxoid-five-component acellular pertussis (DTaP5), inactivated poliovirus (IPV), and haemophilus influenzae type b (Hib) vaccine compared with a DTaP3-IPV/Hib vaccine administered at 3, 5, and 12 months of age. (23966556)
2013
15
Pertussis resurgence: waning immunity and pathogen adaptation - two sides of the same coin. (23406868)
2013
16
Leukocyte transcript alterations in West-African girls following a booster vaccination with diphtheria-tetanus-pertussis vaccine. (23668887)
2013
17
Should acellular pertussis vaccine be recommended to healthcare professionals? (23842996)
2013
18
Information for parents. Whooping cough (pertussis). (24245438)
2013
19
California pertussis epidemic, 2010. (22819634)
2012
20
Pertussis cases rise 10-fold among older children and adults in England and Wales. (22826583)
2012
21
The immunoregulatory role of CD4a8_ FoxP3a8_ CD25a8> regulatory T cells in lungs of mice infected with Bordetella pertussis. (22211712)
2012
22
BapC autotransporter protein of Bordetella pertussis is an adhesion factor. (22052409)
2012
23
Specific biological diagnoses are needed to determine the durability of pertussis vaccine-induced immunity. (22871827)
2012
24
The seroepidemiology of pertussis in NSW: fluctuating immunity profiles related to changes in vaccination schedules. (22243639)
2011
25
Updated recommendations for use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine (Tdap) in pregnant women and persons who have or anticipate having close contact with an infant aged <12 months --- Advisory Committee on Immunization Practices (ACIP), 2011. (22012116)
2011
26
Safety and immunogenicity of three different formulations of a liquid hexavalent diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae b conjugate-hepatitis B vaccine at 2, 4, 6 and 12-14 months of age. (21134456)
2011
27
The effect of vitamin A supplementation and diphtheria-tetanus-pertussis vaccination on parasitaemia in an experimental murine malaria model. (21105844)
2011
28
Primary and booster immunization with a diphtheria, tetanus, acellular pertussis, hepatitis B (DTPa-HBV) and Haemophilus influenzae type b (Hib) vaccine administered separately or together is safe and immunogenic. (19467896)
2010
29
Determinants of the uptake of the full dose of diphtheria-pertussis-tetanus vaccines (DPT3) in Northern Nigeria: a multilevel analysis. (18607704)
2009
30
Combined, reduced-antigen content tetanus, diphtheria, and acellular pertussis vaccine (Boostrix): a review of its use as a single-dose booster immunization in individuals aged 10-64 years in the US. (19697967)
2009
31
A simple and rapid method for quantifying 2-phenoxyethanol (2-PE) in Diphtheria, Tetanus and w-Pertussis (DTwP) vaccine. (17728142)
2008
32
An adolescent-adult formulation tetanus and diptheria toxoids adsorbed combined with acellular pertussis vaccine has comparable immunogenicity but less reactogenicity in children 4-6 years of age than a pediatric formulation acellular pertussis vaccine and diphtheria and tetanus toxoids adsorbed combined with inactivated poliomyelitis vaccine. (17045366)
2007
33
The immunological response of Thai infants to haemophilus influenzae type B polysaccharide-tetanus conjugate vaccine co-administered in the same syringe with locally produced diphtheria-tetanus-pertussis vaccine. (17710973)
2007
34
Comparison of the relative efficacy and potency of mu-opioid agonists to activate Galpha(i/o) proteins containing a pertussis toxin-insensitive mutation. (16436499)
2006
35
TIMP-1 inhibits apoptosis in breast carcinoma cells via a pathway involving pertussis toxin-sensitive G protein and c-Src. (14652000)
2003
36
Differential effects of genistein on apoptosis induced by fluoride and pertussis toxin in human and rat pancreatic islets and RINm5F cells. (11786381)
2002
37
Infantile hypertrophic pyloric stenosis after pertussis prophylaxis with erythromcyin: a case review and cohort study. (10609814)
1999
38
Interferon-inducible protein-10 and lymphotactin induce the chemotaxis and mobilization of intracellular calcium in natural killer cells through pertussis toxin-sensitive and -insensitive heterotrimeric G-proteins. (9271361)
1997
39
The growth-promoting effect of low-density lipoprotein may Be mediated by a pertussis toxin-sensitive mitogen-activated protein kinase pathway. (9281600)
1997
40
A somatostatin receptor inhibits noradrenaline release from chick sympathetic neurons through pertussis toxin-sensitive mechanisms: comparison with the action of alpha 2-adrenoceptors. (8783273)
1996
41
Involvement of pertussis toxin-sensitive mechanism in retinoic acid-induced differentiation of human leukemic HL-60 cells. (7775389)
1995
42
Effects of pertussis and cholera toxin on the interferon-gamma stimulated immunocytochemical staining of ICAM-1 and inositol phosphate formation in a human renal carcinoma cell line. (7908588)
1993
43
Oxytocin-stimulated phosphoinositide hydrolysis in human myometrial cells: involvement of pertussis toxin-sensitive and -insensitive G-proteins. (8386215)
1993
44
Activation of phospholipase C by heat shock requires GTP analogs and is resistant to pertussis toxin. (8314854)
1993
45
Parainfluenza virus type 3 and pertussis syndrome. (8244477)
1993
46
Inversion of Ca2+ current modulation during recovery of neuroblastoma cells from pertussis toxin pretreatment. (7902295)
1993
47
Immunodetectable levels of the inhibitory guanine nucleotide-binding regulatory proteins in failing human heart: discordance with measurements of adenylate cyclase activity and levels of pertussis toxin substrate. (1942080)
1991
48
Mechanism of neutrophil activation by an unopsonized inflammatory particulate. Monosodium urate crystals induce pertussis toxin-insensitive hydrolysis of phosphatidylinositol 4,5-bisphosphate. (1645760)
1991
49
Sequence analysis of cDNA and genomic DNA for a putative pertussis toxin-insensitive guanine nucleotide-binding regulatory protein alpha subunit. (2456569)
1988
50
Action of various drugs with anti-inflammatory or anti-rheumatic properties on pleurisy due to Bordetella pertussis hypersensitivity in the rat. (232922)
1979

Variations for Pertussis

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Expression for genes affiliated with Pertussis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pertussis

Search GEO for disease gene expression data for Pertussis.

Pathways for genes affiliated with Pertussis

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Sources:
50PathCards, 12EMD Millipore, 38NCBI BioSystems Database, 53QIAGEN, 55Reactome, 30KEGG, 60Thomson Reuters, 51PharmGKB
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Pathways related to Pertussis according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Peptide GPCRs38
9.7GNAZ, GNAI1, HCRTR1
29.6GNA14, GNAZ, GNAI1
39.6GNAI1, GNAZ, GNA14
4
Show member pathways
S1P2 pathway38
S1P4 pathway38
S1P5 pathway38
S1P1 pathway38
Sphingosine 1-phosphate (S1P) pathway38
9.6GNA14, GNAZ, GNAI1
5
Show member pathways
D-myo-inositol-5-phosphate metabolism38
superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism38
D-myo-inositol (1,4,5)-trisphosphate degradation38
superpathway of inositol phosphate compounds38
1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)38
D-myo-inositol (1,4,5)-trisphosphate biosynthesis38
myo-inositol biosynthesis38
1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)38
D-myo-inositol (1,3,4)-trisphosphate biosynthesis38
9.4CALML3, CALML5, CALML6
6
Show member pathways
9.4CALML6, CALML5, CALML3
7
Show member pathways
Alzheimers Disease38
9.4CALML6, CALML5, CALML3
8
Show member pathways
9.4CALML6, CALML5, CALML3
9
Show member pathways
Development Beta adrenergic receptors regulation of ERK60
G protein signaling G Protein alpha s signaling cascades60
G protein signaling G Protein beta gamma signaling cascades60
9.3GNAI1, GNAZ, GNG8
10
Show member pathways
9.3GNG8, GNAZ, GNAI1
11
Show member pathways
Development A1 receptor signaling60
G protein signaling G Protein alpha q signaling cascades60
9.3GNAI1, GNAZ, GNG8
129.3GNAI1, GNAZ, GNG8
13
Show member pathways
G protein signaling G Protein alpha 12 signaling pathway60
9.3GNG8, GNAZ, GNAI1
14
Show member pathways
9.3GNG8, GNAZ, GNAI1
15
Show member pathways
9.2GNA14, GNG8, GNAI1
169.2GNA14, CALML3, CALML5, CALML6
17
Show member pathways
9.2CALML6, CALML5, CALML3, OR4D2
18
Show member pathways
9.1CALML6, CALML5, CALML3, GNAI1
19
Show member pathways
9.1GNAI1, CALML3, CALML5, CALML6
209.1GNAI1, CALML3, CALML5, CALML6
21
Show member pathways
9.1GNAI1, CALML3, CALML5, CALML6
22
Show member pathways
9.1GNAI1, CALML3, CALML5, CALML6
23
Show member pathways
9.1GNAI1, CALML3, CALML5, CALML6
249.1GNAI1, CALML3, CALML5, CALML6
25
Show member pathways
9.0GNA14, GNG8, GNAZ, GNAI1
26
Show member pathways
Apoptosis and survival BAD phosphorylation60
Development Alpha 2 adrenergic receptor activation of ERK60
Chemotaxis CXCR4 signaling pathway60
9.0GNA14, GNG8, GNAZ, GNAI1
27
Show member pathways
Signal transduction cAMP signaling60
9.0GNA14, GNG8, GNAZ, GNAI1
28
Show member pathways
9.0GNA14, GNG8, GNAZ, GNAI1
29
Show member pathways
9.0GNAI1, GNAZ, GNG8, GNA14
30
Show member pathways
9.0GNAI1, GNAZ, GNG8, GNA14
31
Show member pathways
9.0GNAI1, GNAZ, GNG8, GNA14
32
Show member pathways
Cytoskeleton remodeling Reverse signaling by ephrin B60
9.0GNAI1, GNAZ, GNG8, GNA14
33
Show member pathways
9.0GNAI1, GNAZ, GNG8, GNA14
34
Show member pathways
9.0GNAI1, GNAZ, GNG8, GNA14
35
Show member pathways
9.0GNAI1, GNAZ, GNG8, GNA14
36
Show member pathways
9.0GNAI1, GNAZ, GNG8, GNA14
379.0GNAI1, GNAZ, GNG8, GNA14
38
Show member pathways
9.0GNAI1, GNAZ, GNG8, GNA14
39
Show member pathways
8.9HCRTR1, GNG8, GNA14, FFAR3
40
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
8.8CALML6, CALML5, CALML3, GNAZ, GNAI1
41
Show member pathways
8.8GNAI1, GNAZ, GNG8, GNA14, CNR1
42
Show member pathways
8.8GNAI1, GNG8, GNA14, CCL15
43
Show member pathways
8.5GNAI1, GNAZ, GNG8, GNA14, CCL15
44
Show member pathways
8.5GNAI1, GNAZ, GNG8, GNA14, CCL15
45
Show member pathways
8.4GNAI1, GNG8, CALML3, CALML5, CALML6
46
Show member pathways
Calcium Regulation in the Cardiac Cell38
8.4GNG8, GNAZ, GNAI1, GUCA2B
47
Show member pathways
8.2GNAI1, GNG8, CNR1, CALML3, CALML5, CALML6
48
Show member pathways
8.2CALML6, CALML5, CALML3, CNR1, GNG8, GNAI1
49
Show member pathways
8.1HCRTR1, GNAI1, GNAZ, GNG8, FFAR3, CNR1
50
Show member pathways
7.6HCRTR1, GNAI1, GNAZ, GNG8, GNA14, FFAR3

Compounds for genes affiliated with Pertussis

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Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 61Tocris Bioscience, 24HMDB, 51PharmGKB
See all sources

Compounds related to Pertussis according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1nabilone45 1111.5CNR1, CNR2
2[3h]win55212-22910.5CNR1, CNR2
3am63045 2911.5CNR1, CNR2
4sr14452845 2911.5CNR1, CNR2
5[3h]cp559402910.5CNR1, CNR2
6win 55212 24510.5CNR1, CNR2
7cp5594045 2911.5CNR1, CNR2
8cannabinol45 2911.4CNR1, CNR2
9win55212-22910.4CNR2, CNR1
10am25145 2911.4CNR2, CNR1
11hu-2102910.4CNR2, CNR1
12marijuana4510.4CNR2, CNR1
13echinacea4510.4CNR1, CNR2
14cannabidiol29 4511.4CNR1, CNR2
15delta9-tetrahydrocannabinol2910.4CNR2, CNR1
162-arachidonoylglycerol45 2911.4CNR2, CNR1
17rimonabant45 29 1112.3CNR1, CNR2
18capsazepine61 45 2912.3CNR1, CNR2
19pyrazole45 1111.3CNR2, CNR1
20monoacylglycerol4510.1CNR1, CNR2
21delta9-tetrahydrocannabinol4510.1GNAI1, CNR1, CNR2
22quinpirole45 2911.0CNR1, GNAI1
23carbon4510.0ART1, CNR2, CNR1
24guanosine 5-o-(3-thiotriphosphate)459.8OR4D2, GNAI1
25gtp45 2910.6GNAI1, GNAZ, OR4D2, CNR2
26gdp459.6OR4D2, GNAZ, GNAI1
27pertussis toxin619.4GNA14, GNG8, GNAZ, GNAI1
28gallein619.4GNA14, GNG8, GNAZ, GNAI1
29g-protein antagonist peptide619.4GNA14, GNG8, GNAZ, GNAI1
30suramin hexasodium salt619.4GNAI1, GNAZ, GNG8, GNA14
318-bromo-cgmp, sodium salt619.4GNA14, GNG8, GNAZ, GNAI1
32adenylate459.4HCRTR1, GNAI1, CNR1, CNR2
33Guanosine monophosphate249.4GNAI1, GNAZ, GNG8, GNA14
34Guanosine diphosphate249.3GNAI1, GNAZ, GNG8, GNA14
35dopamine45 29 24 1112.3HCRTR1, GNAI1, CNR1, RABEP2
36cgmp45 2910.3GNAZ, GNAI1, GUCA2B
37cyclic amp45 2410.1CNR2, CNR1, OR4D2, GNAI1
38Guanosine triphosphate248.8GNAI1, GNAZ, GNG8, GNA14, RABEP2
39calcium45 51 24 1110.7HCRTR1, GNAI1, GNAZ, FFAR3, OR4D2, CCL15

GO Terms for genes affiliated with Pertussis

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Sources:
16Gene Ontology
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Cellular components related to Pertussis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extrinsic component of cytoplasmic side of plasma membraneGO:0312349.3GNAI1, GNAZ, GNA14, CNR2
2integral component of plasma membraneGO:0058879.1FFAR3, CNR1, CNR2, ART1, HCRTR1
3heterotrimeric G-protein complexGO:0058349.0GNA14, GNG8, GNAZ, GNAI1
4plasma membraneGO:0058866.7HCRTR1, GPR84, GNAI1, GNAZ, GNG8, GNA14

Biological processes related to Pertussis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of action potentialGO:04575910.2CNR1, CNR2
2negative regulation of mast cell activationGO:03300410.2CNR1, CNR2
3negative regulation of nitric-oxide synthase activityGO:05100110.1CNR2, CNR1
4adenylate cyclase-modulating G-protein coupled receptor signaling pathwayGO:00718810.0CNR1, GNA14, GNAZ
5adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:0071939.9GNAZ, GNAI1
6G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.8CNR2, CNR1
7negative regulation of blood pressureGO:0457769.4CNR1, GUCA2B
8G-protein coupled receptor signaling pathwayGO:0071868.7GNAI1, GNAZ, GNG8, FFAR3

Molecular functions related to Pertussis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cannabinoid receptor activityGO:00494910.1CNR2, CNR1
2G-protein coupled serotonin receptor bindingGO:0318219.9GNAZ, GNAI1
3G-protein beta/gamma-subunit complex bindingGO:0316839.7GNA14, GNAZ, GNAI1
4G-protein coupled receptor activityGO:0049309.1OR4D2, FFAR3, GPR84, HCRTR1
5GTPase activityGO:0039248.9GNAI1, GNAZ, GNG8, GNA14
6signal transducer activityGO:0048718.7GNAI1, GNAZ, GNG8, GNA14

Products for genes affiliated with Pertussis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pertussis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet