MCID: PRT037
MIFTS: 64

Pertussis malady

Infectious diseases category

Summaries for Pertussis

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8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Whooping cough is an infectious bacterial disease that causes uncontrollable coughing. the name comes from the noise you make when you take a breath after you cough. you may have choking spells or may cough so hard that you vomit. anyone can get whooping cough, but it is more common in infants and children. it's especially dangerous for infants. the coughing spells can be so bad that it is hard for infants to eat, drink, or breathe. to make a diagnosis, your doctor may do a physical exam, blood tests, chest x-rays, or nose or throat cultures. before there was a vaccine, whooping cough was one of the most common childhood diseases and a major cause of childhood deaths in the u.s. now most cases are prevented by vaccines. if you have whooping cough, treatment with antibiotics may help if given early. centers for disease control and prevention

MalaCards: Pertussis, also known as whooping cough, is related to alzheimer's disease and diphtheria. An important gene associated with Pertussis is CNR2 (cannabinoid receptor 2 (macrophage)), and among its related pathways are Signaling by GPCR and Class A/1 (Rhodopsin-like receptors). The drugs erythromycin pwdr and guaifenesin and the compounds calcium and gtp have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract, testes and t cells.

Disease Ontology:8 A commensal bacterial infectious disease that results in inflammation located in respiratory tract, has material basis in bordetella pertussis, or has material basis in bordetella parapertussis, which produce toxins that paralyze the cilia of the respiratory epithelial cells. the infection is characterized by a prolonged, high-pitched, deeply indrawn breath (whoop).

CDC:3 Pertussis, also known as whooping cough, is a highly contagious respiratory disease. It is caused by the bacterium Bordetella pertussis.

Wikipedia:63 Pertussis — commonly called whooping cough (/ˈwuːpɪŋ/, /ˈhuːpɪŋ/, or /ˈhwuːpɪŋ kɒf/) —... more...

Aliases & Classifications for Pertussis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 33MedlinePlus, 56SNOMED-CT, 34MeSH, 26ICD10 via Orphanet, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

pertussis 8 42 10 48 60
whooping cough 8 42 48 33
whooping cough due to unspecified organism 60
bordetella pertussis infection 42
bordetella infections 60
bordetella infection 8
wc - whooping cough 8


External Ids:

Disease Ontology8 DOID:1116
MeSH34 D001885
ICD10 via Orphanet26 A37.1, A37.0, A37.8 A37.9, more
MESH via Orphanet35 D014917
SNOMED-CT56 26484003
SNOMED-CT via Orphanet57 27836007
UMLS via Orphanet61 C0043167

Related Diseases for Pertussis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Pertussis:



Diseases related to pertussis

Clinical Features for Pertussis

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Drugs & Therapeutics for Pertussis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Pertussis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Pertussis

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Anatomical Context for Pertussis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Pertussis:

32
Testes, T cells, Monocytes, Endothelial, Heart, Smooth muscle, Brain, Lung, B cells, Adipocyte, Pituitary, Breast, Thymus, Lymph node, Ovary, Trachea, Pancreatic islet, Whole blood

FMA organs/tissues related to Pertussis:

14
Respiratory tract

Animal Models for Pertussis or affiliated genes

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Publications for Pertussis

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50PubMed
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Articles related to Pertussis:

(show top 50)    (show all 975)
idTitleAuthorsYear
1
Randomized, controlled, multicenter study of the immunogenicity and safety of a fully liquid combination diphtheria-tetanus toxoid-five-component acellular pertussis (DTaP5), inactivated poliovirus (IPV), and haemophilus influenzae type b (Hib) vaccine compared with a DTaP3-IPV/Hib vaccine administered at 3, 5, and 12 months of age. (23966556)
2013
2
Pertussis vaccination and pregnancy. (23580733)
2013
3
Severe infantile Bordetella pertussis pneumonia in monozygotic twins with a congenital C3 deficiency. (23963626)
2013
4
Infant hospitalizations for pertussis before and after Tdap recommendations for adolescents. (24144713)
2013
5
Virulence of pertactin-negative Bordetella pertussis isolates from infants, France. (23621904)
2013
6
Mannose receptor and macrophage galactose-type lectin are involved in Bordetella pertussis mast cell interaction. (23794711)
2013
7
Wheezing in Children with Pertussis Associated with Delayed Pertussis Diagnosis. (24168977)
2013
8
Cost of Bordetella pertussis illness in tertiary hospitals in Argentina. (23912286)
2013
9
The RNA chaperone Hfq is required for virulence of Bordetella pertussis. (23980112)
2013
10
Epidemiological and immunological reasons for pertussis vaccination in adolescents and adults. (23419520)
2013
11
A CpG-containing oligodeoxynucleotide adjuvant for acellular pertussis vaccine improves the protective response against Bordetella pertussis. (23291942)
2013
12
Epidemiology of pertussis in an urban region of Poland: time for a booster for adolescents and adults. (22826068)
2013
13
Pertussis: a re-emerging or under diagnosed infectious disease? (23607918)
2013
14
Waning immunity to pertussis following 5 doses of DTaP. (23478868)
2013
15
Pertactin-negative variants of Bordetella pertussis in New York State: A retrospective analysis, 2004-2013. (24365130)
2013
16
The immunoregulatory role of CD4a8_ FoxP3a8_ CD25a8> regulatory T cells in lungs of mice infected with Bordetella pertussis. (22211712)
2012
17
Influenza and tetanus, diphtheria, and acellular pertussis vaccinations during pregnancy. (22495061)
2012
18
Non-specific effects of diphtheria-tetanus-pertussis and measles vaccinations? An analysis of surveillance data from Navrongo, Ghana. (23006334)
2012
19
ACIP: Give pertussis vaccine during every pregnancy. (23168806)
2012
20
The Bordetella pertussis model of exquisite gene control by the global transcription factor BvgA. (22628479)
2012
21
A randomized, dose-ranging assessment of the immunogenicity and safety of a booster dose of a combined diphtheria-tetanus-whole cell pertussis-hepatitis B-inactivated poliovirus-Hemophilus influenzae type b (DTPw-HBV-IPV/Hib) vaccine vs. co-administration of DTPw-HBV/Hib and IPV vaccines in 12 to 24 months old Filipino toddlers. (22330958)
2012
22
Workshop on Animal free Detection of Pertussis Toxin in Vaccines--Alternatives to the Histamine Sensitisation Test. (22609106)
2012
23
Increased population prevalence of low pertussis toxin antibody levels in young children preceding a record pertussis epidemic in Australia. (22558249)
2012
24
Leukoreduction in patients with severe pertussis with hyperleukocytosis. (22549439)
2012
25
The seroepidemiology of pertussis in NSW: fluctuating immunity profiles related to changes in vaccination schedules. (22243639)
2011
26
Comments on cow's milk allergy and diphtheria, tetanus, and pertussis vaccines. (21807255)
2011
27
Immunogenicity and safety of a pentavalent acellular pertussis combined vaccine including diphtheria, tetanus, inactivated poliovirus and conjugated Haemophilus Influenzae type b polysaccharide for primary vaccination at 2, 3, 4 or 3, 4, 5 months of age in infants in China. (21219984)
2011
28
FHA-mediated cell-substrate and cell-cell adhesions are critical for Bordetella pertussis biofilm formation on abiotic surfaces and in the mouse nose and the trachea. (22216115)
2011
29
Immunogenicity and safety of an investigational hexavalent diphtheria-tetanus-acellular pertussis-inactivated poliovirus-hepatitis B-Haemophilus influenzae B conjugate combined vaccine in healthy 2-, 4-, and 6-month-old Argentinean infants. (21372751)
2011
30
Is adolescent pertussis vaccination preferable to natural booster infections? (22111856)
2011
31
CCR1-mediated activation of Nuclear Factor-kappaB in THP-1 monocytic cells involves Pertussis Toxin-insensitive Galpha(14) and Galpha(16) signaling cascades. (19687291)
2009
32
Primary immunization with a triple diphtheria-tetanus-whole cell pertussis vaccine in Iranian infants: an analysis of antibody response. (19671937)
2009
33
IgG responses after booster vaccination with different pertussis vaccines in Dutch children 4 years of age: effect of vaccine antigen content. (19729085)
2009
34
Booster vaccination of adults with reduced-antigen-content diphtheria, Tetanus and pertussis vaccine: immunogenicity 5 years post-vaccination. (19095033)
2009
35
Coregulation of natively expressed pertussis toxin-sensitive muscarinic receptors with G-protein-activated potassium channels. (17567799)
2007
36
Sudden and unexpected deaths after the administration of hexavalent vaccines (diphtheria, tetanus, pertussis, poliomyelitis, hepatitis B, Haemophilius influenzae type b): is there a signal? (15602672)
2005
37
Fc receptor-mediated immunity against Bordetella pertussis. (11714823)
2001
38
From the Centers for Disease Control and Prevention. Hypertrophic pyloric stenosis in infants following pertussis prophylaxis with erythromycin--Knoxville, Tennessee, 1999. (10659863)
2000
39
Semiquantitative polymerase chain reaction enzyme immunoassay for the diagnosis of pertussis. (10584906)
1999
40
Pertussis toxin-sensitive and insensitive intracellular signalling pathways in undifferentiated 3T3-L1 cells stimulated by insulin converge with phosphatidylinositol 3-kinase upstream of the Ras mitogen-activated protein kinase cascade. (10092867)
1999
41
Different mechanisms are involved in intracellular calcium increase by insulin-like growth factors 1 and 2 in articular chondrocytes: voltage-gated calcium channels, and/or phospholipase C coupled to a pertussis-sensitive G-protein. (9057099)
1997
42
Etorphine elicits anomalous excitatory opioid effects on sensory neurons treated with GM1 ganglioside or pertussis toxin in contrast to its potent inhibitory effects on naive or chronic morphine-treated cells. (9001733)
1996
43
Tyrosine phosphorylation of an SH2-containing protein tyrosine phosphatase is coupled to platelet thrombin receptor via a pertussis toxin-sensitive heterotrimeric G-protein. (7781604)
1995
44
Coupling of muscarinic m1, m2 and m3 acetylcholine receptors, expressed in Chinese hamster ovary cells, to pertussis toxin-sensitive/insensitive guanine nucleotide-binding proteins. (7621908)
1995
45
Somatostatin acts via a pertussis toxin-sensitive mechanism on calcitonin secretion in C-cells. (1362426)
1992
46
Inhibition of muscle cell relaxation by somatostatin: tissue-specific, cAMP-dependent, pertussis toxin-sensitive. (1677535)
1991
47
Surface-exposed antibody-accessible outer membrane proteins of Bordetella pertussis. (1954571)
1991
48
Molecular interaction of the human alpha 2-C10-adrenergic receptor, when expressed in Rat-1 fibroblasts, with multiple pertussis toxin-sensitive guanine nucleotide-binding proteins: studies with site-directed antisera. (1658601)
1991
49
Somatostatin and epinephrine decrease insulin messenger ribonucleic acid in HIT cells through a pertussis toxin-sensitive mechanism. (1682135)
1991
50
Neuropeptide Y and peptide YY inhibit lipolysis in human and dog fat cells through a pertussis toxin-sensitive G protein. (2104880)
1990

Genetic Variations for Pertussis

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Expression for genes affiliated with Pertussis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pertussis

Search GEO for disease gene expression data for Pertussis.

Pathways for genes affiliated with Pertussis

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 51QIAGEN
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Pathways related to Pertussis according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.5CNR1, GNA14, GNAI1, GNAZ, OR4D2, P2RY4
2
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11.2CNR1, CNR2, GNAI1, P2RY13, P2RY4, FFAR3
3
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11.1CALML5, CALML3, CALML6, GNAI1, CNR1
4
Development Endothelin-1/EDNRA signaling
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11.1CALML6, CALML5, CALML3, GNAZ, GNAI1
511.1GNAI1, CALML5, CALML6, PYCARD, CALML3
6
Hide members
11.0CNR1, GNAZ, GNAI1, GNA14
711.0CALML5, CALML3, GNA14, CALML6
811.0CALML3, GNAI1, CALML6, CALML5
9
Hide members
11.0CALML3, CALML5, GNAI1, CALML6
10
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11.0CALML3, CALML6, CALML5, GNAI1
11
Hide members
11.0CALML3, CALML5, GNAI1, CALML6
12
Hide members
11.0CALML6, GNAI1, CALML5, CALML3
1310.8GNAI1, GNAZ, GNA14
14
Signal transduction cAMP signaling
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10.8GNA14, GNAZ, GNAI1
15
Hide members
10.8GNA14, GNAZ, GNAI1
16
Hide members
10.8GNAZ, GNA14, GNAI1
1710.8GNAZ, GNAI1, GNA14
1810.8GNAZ, GNAI1, GNA14
19
Hide members
10.8GNA14, GNAZ, GNAI1
2010.8GNAZ, GNAI1, P2RY13
21
Hide members
10.8CALML5, CALML3, CALML6
2210.8CALML3, CALML5, CALML6
23
Hide members
10.8CALML5, CALML6, CALML3
24
Hide members
10.7CNR2, CNR1
25
Hide members
10.7GNAI1, GNAZ
26
Hide members
10.7P2RY13, P2RY4

Compounds for genes affiliated with Pertussis

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Pertussis according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2415.1CCL15, CALML3, CALML5, GNAI1, GNAZ, OR4D2
2gtp44 2812.4P2RY4, CNR2, OR4D2, GNAZ, GNAI1
3delta9-tetrahydrocannabinol4411.2CNR2, CNR1, GNAI1
4gallein5911.2GNAZ, GNAI1, GNA14
5g-protein antagonist peptide5911.2GNAZ, GNAI1, GNA14
6suramin hexasodium salt5911.2GNA14, GNAI1, GNAZ
7pertussis toxin5911.2GNAZ, GNAI1, GNA14
88-bromo-cgmp, sodium salt5911.2GNAZ, GNAI1, GNA14
9nabilone44 1112.1CNR1, CNR2
10[3h]win55212-22811.1CNR1, CNR2
11am63044 2812.1CNR1, CNR2
12sr14452844 2812.1CNR1, CNR2
13cannabinol44 2812.1CNR1, CNR2
14[3h]cp559402811.1CNR1, CNR2
15cp5594028 4412.1CNR1, CNR2
16win 55212 24411.1CNR1, CNR2
17win55212-22811.1CNR1, CNR2
18am25128 4412.0CNR1, CNR2
19marijuana4411.0CNR2, CNR1
20hu-2102811.0CNR2, CNR1
21echinacea4411.0CNR1, CNR2
22cannabidiol28 4412.0CNR1, CNR2
23δ9-tetrahydrocannabinol2811.0CNR2, CNR1
24Dronabinol1111.0CNR2, CNR1
25alpha,beta-methyleneadenosine 5-triphosphate trisodium salt5911.0P2RY13, P2RY4
26mrs 2179 tetrasodium salt5911.0P2RY4, P2RY13
27utpgammas trisodium salt5910.9P2RY4, P2RY13
28mrs 23655910.9P2RY13, P2RY4
29mrs 2500 tetraammonium salt5910.9P2RY13, P2RY4
302-arachidonoylglycerol44 2811.9CNR1, CNR2
31capsazepine44 59 2812.8CNR1, CNR2
32rimonabant44 28 1112.8CNR1, CNR2
33monoacylglycerol4410.7CNR2, CNR1
34ppads44 2811.7P2RY4, P2RY13
35pyrazole44 1111.6CNR1, CNR2
36quinpirole44 2811.4CNR1, GNAI1

GO Terms for genes affiliated with Pertussis

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16Gene Ontology
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Cellular components related to Pertussis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.6ART1, OR4D2, GNAZ, GNAI1, GNA14, FFAR3
2extrinsic to internal side of plasma membraneGO:03123410.9CNR2, GNAZ, GNAI1, GNA14
3heterotrimeric G-protein complexGO:00583410.8GNAZ, GNAI1, GNA14

Biological processes related to Pertussis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1adenylate cyclase-modulating G-protein coupled receptor signaling pathwayGO:00718810.8CNR1, GNAZ, GNA14
2negative regulation of nitric-oxide synthase activityGO:05100110.7CNR2, CNR1
3negative regulation of mast cell activationGO:03300410.6CNR2, CNR1
4negative regulation of action potentialGO:04575910.4CNR2, CNR1

Molecular functions related to Pertussis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1G-protein beta/gamma-subunit complex bindingGO:03168310.8GNAZ, GNAI1, GNA14
2G-protein coupled purinergic nucleotide receptor activityGO:04502810.7P2RY4, P2RY13
3cannabinoid receptor activityGO:00494910.6CNR2, CNR1
4G-protein coupled serotonin receptor bindingGO:03182110.4GNAZ, GNAI1

Products for genes affiliated with Pertussis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pertussis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet