MCID: PRT037
MIFTS: 54

Pertussis malady

Rare diseases, Infectious diseases, Respiratory diseases categories

Summaries for Pertussis

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MedlinePlus:32 Whooping cough is an infectious bacterial disease that causes uncontrollable coughing. the name comes from the noise you make when you take a breath after you cough. you may have choking spells or may cough so hard that you vomit. anyone can get whooping cough, but it is more common in infants and children. it's especially dangerous for infants. the coughing spells can be so bad that it is hard for infants to eat, drink, or breathe. to make a diagnosis, your doctor may do a physical exam, blood tests, chest x-rays, or nose or throat cultures. before there was a vaccine, whooping cough was one of the most common childhood diseases and a major cause of childhood deaths in the u.s. now most cases are prevented by vaccines. if you have whooping cough, treatment with antibiotics may help if given early. centers for disease control and prevention

MalaCards based summary: Pertussis, also known as whooping cough, is related to cholera and diphtheria. An important gene associated with Pertussis is CNR2 (cannabinoid receptor 2 (macrophage)), and among its related pathways are Neuropeptides signaling through G protein alpha i and G protein alpha q and LPA receptor mediated events. The drugs erythromycin pwdr and guaifenesin and the compounds nabilone and [3h]win55212-2 have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract, testes and t cells.

Disease Ontology:9 A commensal bacterial infectious disease that results in inflammation located in respiratory tract, has material basis in bordetella pertussis, or has material basis in bordetella parapertussis, which produce toxins that paralyze the cilia of the respiratory epithelial cells. the infection is characterized by a prolonged, high-pitched, deeply indrawn breath (whoop).

Wikipedia:63 Pertussis, also known as whooping cough or 100 day cough, is a highly contagious bacterial disease.... more...

Aliases & Classifications for Pertussis

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 47Orphanet, 3CDC, 60UMLS, 32MedlinePlus, 55SNOMED-CT, 33MeSH, 26ICD10 via Orphanet, 61UMLS via Orphanet, 34MESH via Orphanet, 25ICD10
See all sources

Pertussis, Aliases & Descriptions:

Name: Pertussis 9 41 11 47 3 60
Whooping Cough 9 41 47 32 3
Whooping Cough Due to Unspecified Organism 60
Bordetella Pertussis Infection 41
 
Bordetella Infections 60
Bordetella Infection 9
Wc - Whooping Cough 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Respiratory diseases


External Ids:

Disease Ontology9 DOID:1116
MeSH33 D001885
Orphanet47 1489
ICD10 via Orphanet26 A37.0, A37.1, A37.8 A37.9, more
SNOMED-CT55 26484003
UMLS via Orphanet61 C0043167
MESH via Orphanet34 D014917

Related Diseases for Pertussis

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Graphical network of the top 20 diseases related to Pertussis:



Diseases related to pertussis

Symptoms for Pertussis

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Drugs & Therapeutics for Pertussis

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Drug clinical trials:

Search ClinicalTrials for Pertussis

Search NIH Clinical Center for Pertussis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Pertussis

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Anatomical Context for Pertussis

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MalaCards organs/tissues related to Pertussis:

31
Testes, T cells, Monocytes, Neutrophil, Endothelial, Heart, Brain, Smooth muscle, Lung, Adipocyte, B cells, Breast, Pituitary, Lymph node, Thymus, Ovary, Nk cells, Trachea, Pancreatic islet, Whole blood

FMA organs/tissues related to Pertussis:

14
Respiratory tract

Animal Models for Pertussis or affiliated genes

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Publications for Pertussis

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Articles related to Pertussis:

(show top 50)    (show all 1028)
idTitleAuthorsYear
1
Pertussis in infants less than 6 months of age and household contacts, Italy April 2014. (25874559)
2015
2
Sources of Pertussis Infection in Young Babies From SA8o Paulo State, Brazil. (25386966)
2014
3
Management and prevention of pertussis infection in neonates. (25371322)
2014
4
Vaccination with tetanus, diphtheria, and acellular pertussis vaccine of pregnant women enrolled in Medicaid--Michigan, 2011-2013. (25254561)
2014
5
Health care worker exposures to pertussis: missed opportunities for prevention. (24344101)
2014
6
The "how" of polymerase chain reaction testing for Bordetella pertussis depends on the "why". (23087394)
2013
7
Combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Hemophilus influenzae type b vaccine; Infanrixa8c hexa: Twelve years of experience in Italy. (24004825)
2013
8
Identification of biomarkers to detect residual pertussis toxin using microarray analysis of dendritic cells. (24055089)
2013
9
Attitudes, knowledge and perceptions towards whooping cough and pertussis vaccine in hospitalized adults. (24370707)
2013
10
A proteoliposome formulation derived from Bordetella pertussis induces protection in two murine challenge models. (23458724)
2013
11
Prevalence and molecular characterization of pertactin-deficient Bordetella pertussis in the US. (24256623)
2013
12
Bordetella holmesii and pertussis diagnosis: authors' reply. (23842047)
2013
13
Attitude of Italian physicians toward pertussis diagnosis. (23732898)
2013
14
Cost-effectiveness analysis of a pertussis vaccination programme for Japan considering intergenerational infection. (23570987)
2013
15
Tdap vaccination during pregnancy to reduce pertussis infection in young infants. (23673584)
2013
16
Genome Sequences of 28 Bordetella pertussis U.S. Outbreak Strains Dating from 2010 to 2012. (24356839)
2013
17
Pertussis vaccination of health care workers: ACOEM medical center occupational health section task force on pertussis vaccination of health care workers. (24013658)
2013
18
Randomized, controlled, multicenter study of the immunogenicity and safety of a fully liquid combination diphtheria-tetanus toxoid-five-component acellular pertussis (DTaP5), inactivated poliovirus (IPV), and haemophilus influenzae type b (Hib) vaccine compared with a DTaP3-IPV/Hib vaccine administered at 3, 5, and 12 months of age. (23966556)
2013
19
Pertussis resurgence: waning immunity and pathogen adaptation - two sides of the same coin. (23406868)
2013
20
Leukocyte transcript alterations in West-African girls following a booster vaccination with diphtheria-tetanus-pertussis vaccine. (23668887)
2013
21
California pertussis epidemic, 2010. (22819634)
2012
22
Pertussis cases rise 10-fold among older children and adults in England and Wales. (22826583)
2012
23
The immunoregulatory role of CD4a8_ FoxP3a8_ CD25a8> regulatory T cells in lungs of mice infected with Bordetella pertussis. (22211712)
2012
24
Number and order of whole cell pertussis vaccines in infancy and disease protection. (22851107)
2012
25
BapC autotransporter protein of Bordetella pertussis is an adhesion factor. (22052409)
2012
26
The seroepidemiology of pertussis in NSW: fluctuating immunity profiles related to changes in vaccination schedules. (22243639)
2011
27
Updated recommendations for use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine (Tdap) in pregnant women and persons who have or anticipate having close contact with an infant aged <12 months --- Advisory Committee on Immunization Practices (ACIP), 2011. (22012116)
2011
28
Safety and immunogenicity of three different formulations of a liquid hexavalent diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae b conjugate-hepatitis B vaccine at 2, 4, 6 and 12-14 months of age. (21134456)
2011
29
The effect of vitamin A supplementation and diphtheria-tetanus-pertussis vaccination on parasitaemia in an experimental murine malaria model. (21105844)
2011
30
Combination of pneumococcal surface protein A (PspA) with whole cell pertussis vaccine increases protection against pneumococcal challenge in mice. (20523738)
2010
31
Determinants of the uptake of the full dose of diphtheria-pertussis-tetanus vaccines (DPT3) in Northern Nigeria: a multilevel analysis. (18607704)
2009
32
A simple and rapid method for quantifying 2-phenoxyethanol (2-PE) in Diphtheria, Tetanus and w-Pertussis (DTwP) vaccine. (17728142)
2008
33
An adolescent-adult formulation tetanus and diptheria toxoids adsorbed combined with acellular pertussis vaccine has comparable immunogenicity but less reactogenicity in children 4-6 years of age than a pediatric formulation acellular pertussis vaccine and diphtheria and tetanus toxoids adsorbed combined with inactivated poliomyelitis vaccine. (17045366)
2007
34
The immunological response of Thai infants to haemophilus influenzae type B polysaccharide-tetanus conjugate vaccine co-administered in the same syringe with locally produced diphtheria-tetanus-pertussis vaccine. (17710973)
2007
35
Comparison of the relative efficacy and potency of mu-opioid agonists to activate Galpha(i/o) proteins containing a pertussis toxin-insensitive mutation. (16436499)
2006
36
TIMP-1 inhibits apoptosis in breast carcinoma cells via a pathway involving pertussis toxin-sensitive G protein and c-Src. (14652000)
2003
37
Differential effects of genistein on apoptosis induced by fluoride and pertussis toxin in human and rat pancreatic islets and RINm5F cells. (11786381)
2002
38
Critical involvement of p38 MAP kinase in pertussis toxin-induced cytoskeletal reorganization and lung permeability. (12087068)
2002
39
Infantile hypertrophic pyloric stenosis after pertussis prophylaxis with erythromcyin: a case review and cohort study. (10609814)
1999
40
Interferon-inducible protein-10 and lymphotactin induce the chemotaxis and mobilization of intracellular calcium in natural killer cells through pertussis toxin-sensitive and -insensitive heterotrimeric G-proteins. (9271361)
1997
41
The growth-promoting effect of low-density lipoprotein may Be mediated by a pertussis toxin-sensitive mitogen-activated protein kinase pathway. (9281600)
1997
42
A somatostatin receptor inhibits noradrenaline release from chick sympathetic neurons through pertussis toxin-sensitive mechanisms: comparison with the action of alpha 2-adrenoceptors. (8783273)
1996
43
Involvement of pertussis toxin-sensitive mechanism in retinoic acid-induced differentiation of human leukemic HL-60 cells. (7775389)
1995
44
Effects of pertussis and cholera toxin on the interferon-gamma stimulated immunocytochemical staining of ICAM-1 and inositol phosphate formation in a human renal carcinoma cell line. (7908588)
1993
45
Oxytocin-stimulated phosphoinositide hydrolysis in human myometrial cells: involvement of pertussis toxin-sensitive and -insensitive G-proteins. (8386215)
1993
46
Activation of phospholipase C by heat shock requires GTP analogs and is resistant to pertussis toxin. (8314854)
1993
47
Parainfluenza virus type 3 and pertussis syndrome. (8244477)
1993
48
Inversion of Ca2+ current modulation during recovery of neuroblastoma cells from pertussis toxin pretreatment. (7902295)
1993
49
Immunodetectable levels of the inhibitory guanine nucleotide-binding regulatory proteins in failing human heart: discordance with measurements of adenylate cyclase activity and levels of pertussis toxin substrate. (1942080)
1991
50
Action of various drugs with anti-inflammatory or anti-rheumatic properties on pleurisy due to Bordetella pertussis hypersensitivity in the rat. (232922)
1979

Variations for Pertussis

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Expression for genes affiliated with Pertussis

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Search GEO for disease gene expression data for Pertussis.

Pathways for genes affiliated with Pertussis

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Pathways related to Pertussis according to GeneCards Suite gene sharing:

(show top 50)    (show all 62)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6GNA14, GNAZ, GNAI1
29.6GNAI1, GNAZ, GNA14
3
Show member pathways
S1P2 pathway36
S1P4 pathway36
S1P5 pathway36
S1P1 pathway36
Sphingosine 1-phosphate (S1P) pathway36
9.6GNA14, GNAZ, GNAI1
4
Show member pathways
D-myo-inositol-5-phosphate metabolism36
superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism36
D-myo-inositol (1,4,5)-trisphosphate degradation36
superpathway of inositol phosphate compounds36
1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)36
D-myo-inositol (1,4,5)-trisphosphate biosynthesis36
myo-inositol biosynthesis36
1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)36
D-myo-inositol (1,3,4)-trisphosphate biosynthesis36
9.4CALML3, CALML5, CALML6
5
Show member pathways
9.4CALML6, CALML5, CALML3
6
Show member pathways
Alzheimers Disease36
9.4CALML6, CALML5, CALML3
7
Show member pathways
9.4CALML6, CALML5, CALML3
8
Show member pathways
Development Beta adrenergic receptors regulation of ERK58
G protein signaling G Protein alpha s signaling cascades58
G protein signaling G Protein beta gamma signaling cascades58
9.3GNAI1, GNAZ, GNG8
9
Show member pathways
9.3GNG8, GNAZ, GNAI1
10
Show member pathways
Development A1 receptor signaling58
G protein signaling G Protein alpha q signaling cascades58
9.3GNAI1, GNAZ, GNG8
119.3GNAI1, GNAZ, GNG8
12
Show member pathways
G protein signaling G Protein alpha 12 signaling pathway58
9.3GNG8, GNAZ, GNAI1
13
Show member pathways
9.3GNG8, GNAZ, GNAI1
14
Show member pathways
9.2GNA14, GNG8, GNAI1
159.2GNA14, CALML3, CALML5, CALML6
16
Show member pathways
9.2CALML6, CALML5, CALML3, OR4D2
17
Show member pathways
9.1CALML6, CALML5, CALML3, GNAI1
18
Show member pathways
9.1GNAI1, CALML3, CALML5, CALML6
199.1GNAI1, CALML3, CALML5, CALML6
20
Show member pathways
9.1GNAI1, CALML3, CALML5, CALML6
21
Show member pathways
9.1GNAI1, CALML3, CALML5, CALML6
22
Show member pathways
9.1GNAI1, CALML3, CALML5, CALML6
239.1GNAI1, CALML3, CALML5, CALML6
24
Show member pathways
9.0GNA14, GNG8, GNAZ, GNAI1
25
Show member pathways
Apoptosis and survival BAD phosphorylation58
Development Alpha 2 adrenergic receptor activation of ERK58
Chemotaxis CXCR4 signaling pathway58
9.0GNA14, GNG8, GNAZ, GNAI1
26
Show member pathways
Signal transduction cAMP signaling58
9.0GNA14, GNG8, GNAZ, GNAI1
27
Show member pathways
9.0GNA14, GNG8, GNAZ, GNAI1
28
Show member pathways
9.0GNAI1, GNAZ, GNG8, GNA14
29
Show member pathways
9.0GNAI1, GNAZ, GNG8, GNA14
30
Show member pathways
9.0GNAI1, GNAZ, GNG8, GNA14
31
Show member pathways
Cytoskeleton remodeling Reverse signaling by ephrin B58
9.0GNAI1, GNAZ, GNG8, GNA14
32
Show member pathways
9.0GNAI1, GNAZ, GNG8, GNA14
33
Show member pathways
9.0GNAI1, GNAZ, GNG8, GNA14
34
Show member pathways
9.0GNAI1, GNAZ, GNG8, GNA14
35
Show member pathways
9.0GNAI1, GNAZ, GNG8, GNA14
369.0GNAI1, GNAZ, GNG8, GNA14
37
Show member pathways
9.0GNAI1, GNAZ, GNG8, GNA14
38
Show member pathways
8.9HCRTR1, GNG8, GNA14, FFAR3
39
Show member pathways
Cytoskeleton remodeling FAK signaling58
Development Endothelin 1 EDNRA transactivation of EGFR58
8.8CALML6, CALML5, CALML3, GNAZ, GNAI1
40
Show member pathways
8.8GNAI1, GNAZ, GNG8, GNA14, CNR1
41
Show member pathways
8.8GNAI1, GNG8, GNA14, CCL15
42
Show member pathways
8.5GNAI1, GNAZ, GNG8, GNA14, CCL15
43
Show member pathways
8.5GNAI1, GNAZ, GNG8, GNA14, CCL15
44
Show member pathways
8.4GNAI1, GNG8, CALML3, CALML5, CALML6
45
Show member pathways
Calcium Regulation in the Cardiac Cell36
8.4GNG8, GNAZ, GNAI1, GUCA2B
46
Show member pathways
8.2GNAI1, GNG8, CNR1, CALML3, CALML5, CALML6
47
Show member pathways
8.2CALML6, CALML5, CALML3, CNR1, GNG8, GNAI1
48
Show member pathways
8.1HCRTR1, GNAI1, GNAZ, GNG8, FFAR3, CNR1
49
Show member pathways
7.6HCRTR1, GNAI1, GNAZ, GNG8, GNA14, FFAR3

Compounds for genes affiliated with Pertussis

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Compounds related to Pertussis according to GeneCards Suite gene sharing:

(show all 39)
idCompoundScoreTop Affiliating Genes
1nabilone43 1211.5CNR1, CNR2
2[3h]win55212-22810.5CNR1, CNR2
3am63043 2811.5CNR1, CNR2
4sr14452843 2811.5CNR1, CNR2
5[3h]cp559402810.5CNR1, CNR2
6win 55212 24310.5CNR1, CNR2
7cp5594043 2811.5CNR1, CNR2
8cannabinol43 2811.4CNR1, CNR2
9win55212-22810.4CNR2, CNR1
10am25143 2811.4CNR2, CNR1
11hu-2102810.4CNR2, CNR1
12marijuana4310.4CNR2, CNR1
13echinacea4310.4CNR1, CNR2
14cannabidiol28 4311.4CNR1, CNR2
15delta9-tetrahydrocannabinol2810.4CNR2, CNR1
162-arachidonoylglycerol43 2811.4CNR2, CNR1
17rimonabant43 28 1212.3CNR1, CNR2
18capsazepine59 43 2812.3CNR1, CNR2
19pyrazole43 1211.3CNR2, CNR1
20monoacylglycerol4310.1CNR1, CNR2
21delta9-tetrahydrocannabinol4310.1GNAI1, CNR1, CNR2
22quinpirole43 2811.0CNR1, GNAI1
23carbon4310.0ART1, CNR2, CNR1
24guanosine 5-o-(3-thiotriphosphate)439.8OR4D2, GNAI1
25gtp43 2810.6GNAI1, GNAZ, OR4D2, CNR2
26gdp439.6OR4D2, GNAZ, GNAI1
27pertussis toxin599.4GNA14, GNG8, GNAZ, GNAI1
28gallein599.4GNA14, GNG8, GNAZ, GNAI1
29g-protein antagonist peptide599.4GNA14, GNG8, GNAZ, GNAI1
30suramin hexasodium salt599.4GNAI1, GNAZ, GNG8, GNA14
318-bromo-cgmp, sodium salt599.4GNA14, GNG8, GNAZ, GNAI1
32adenylate439.4HCRTR1, GNAI1, CNR1, CNR2
33Guanosine monophosphate249.4GNAI1, GNAZ, GNG8, GNA14
34Guanosine diphosphate249.3GNAI1, GNAZ, GNG8, GNA14
35dopamine43 28 24 1212.3HCRTR1, GNAI1, CNR1, RABEP2
36cgmp43 2810.3GNAZ, GNAI1, GUCA2B
37cyclic amp43 2410.1CNR2, CNR1, OR4D2, GNAI1
38Guanosine triphosphate248.8GNAI1, GNAZ, GNG8, GNA14, RABEP2
39calcium43 49 24 1210.7HCRTR1, GNAI1, GNAZ, FFAR3, OR4D2, CCL15

GO Terms for genes affiliated with Pertussis

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Cellular components related to Pertussis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extrinsic component of cytoplasmic side of plasma membraneGO:00312349.3GNAI1, GNAZ, GNA14, CNR2
2integral component of plasma membraneGO:00058879.1FFAR3, CNR1, CNR2, ART1, HCRTR1
3heterotrimeric G-protein complexGO:00058349.0GNA14, GNG8, GNAZ, GNAI1
4plasma membraneGO:00058866.7HCRTR1, GPR84, GNAI1, GNAZ, GNG8, GNA14

Biological processes related to Pertussis according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of action potentialGO:004575910.2CNR1, CNR2
2negative regulation of mast cell activationGO:003300410.2CNR1, CNR2
3negative regulation of nitric-oxide synthase activityGO:005100110.1CNR2, CNR1
4adenylate cyclase-modulating G-protein coupled receptor signaling pathwayGO:000718810.0CNR1, GNA14, GNAZ
5adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:00071939.9GNAZ, GNAI1
6G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00071879.8CNR2, CNR1
7negative regulation of blood pressureGO:00457769.4CNR1, GUCA2B
8G-protein coupled receptor signaling pathwayGO:00071868.7GNAI1, GNAZ, GNG8, FFAR3

Molecular functions related to Pertussis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cannabinoid receptor activityGO:000494910.1CNR2, CNR1
2G-protein coupled serotonin receptor bindingGO:00318219.9GNAZ, GNAI1
3G-protein beta/gamma-subunit complex bindingGO:00316839.7GNA14, GNAZ, GNAI1
4G-protein coupled receptor activityGO:00049309.1OR4D2, FFAR3, GPR84, HCRTR1
5GTPase activityGO:00039248.9GNAI1, GNAZ, GNG8, GNA14
6signal transducer activityGO:00048718.7GNAI1, GNAZ, GNG8, GNA14

Products for genes affiliated with Pertussis

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Sources for Pertussis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet