MCID: PRT037
MIFTS: 54

Pertussis malady

Infectious category

Summaries for Pertussis

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Whooping cough is an infectious bacterial disease that causes uncontrollable coughing. the name comes from the noise you make when you take a breath after you cough. you may have choking spells or may cough so hard that you vomit. anyone can get whooping cough, but it is more common in infants and children. it's especially dangerous for infants. the coughing spells can be so bad that it is hard for infants to eat, drink, or breathe. to make a diagnosis, your doctor may do a physical exam, blood tests, chest x-rays, or nose or throat cultures. before there was a vaccine, whooping cough was one of the most common childhood diseases and a major cause of childhood deaths in the u.s. now most cases are prevented by vaccines. if you have whooping cough, treatment with antibiotics may help if given early. centers for disease control and prevention

MalaCards: Pertussis, also known as whooping cough, is related to alzheimer's disease and diphtheria. An important gene associated with Pertussis is CNR2 (cannabinoid receptor 2 (macrophage)), and among its related pathways are Signaling by GPCR and Class A/1 (Rhodopsin-like receptors). The drugs erythromycin pwdr and guaifenesin and the compounds calcium and gtp have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract.

Disease Ontology:8 A commensal bacterial infectious disease that results in inflammation located in respiratory tract, has material basis in bordetella pertussis, or has material basis in bordetella parapertussis, which produce toxins that paralyze the cilia of the respiratory epithelial cells. the infection is characterized by a prolonged, high-pitched, deeply indrawn breath (whoop).

CDC:3 Pertussis, also known as whooping cough, is a highly contagious respiratory disease. It is caused by the bacterium Bordetella pertussis.

Wikipedia:64 Pertussis — commonly called whooping cough (/ˈhuːpɪŋ kɒf/ or /ˈhwuːpɪŋ kɒf/) — is a highly... more...

Aliases & Classifications for Pertussis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 49Orphanet, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Aliases & Descriptions:

pertussis 8 43 10 49 61
whooping cough 8 43 49 34
whooping cough due to unspecified organism 61
bordetella pertussis infection 43
bordetella infections 61
bordetella infection 8
wc - whooping cough 8


External Ids:

Disease Ontology8 DOID:1116
MeSH35 D001885
MESH via Orphanet36 D014917
ICD10 via Orphanet26 A37
SNOMED-CT57 26484003
SNOMED-CT via Orphanet58 27836007
UMLS via Orphanet62 C0043167

Related Diseases for Pertussis

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Pertussis:



Diseases related to pertussis

Clinical Features for Pertussis

Drugs & Therapeutics for Pertussis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Pertussis

Drug clinical trials:

Search ClinicalTrials for Pertussis

Search NIH Clinical Center for Pertussis

Search CenterWatch for Pertussis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Pertussis

Anatomical Context for Pertussis

Sources:
14FMA
See all sources

FMA organs/tissues related to Pertussis:

14
Respiratory tract

Animal Models for Pertussis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Pertussis

Sources:
51PubMed
See all sources

Articles related to Pertussis:

(show top 50)    (show all 975)
idTitleAuthorsYear
1
Evaluation of a Multitarget Real-Time PCR Assay for Detection of Bordetella Species during a Pertussis Outbreak in New Hampshire in 2011. (24131698)
2014
2
Report on the international workshop on alternatives to the murine histamine sensitization test (HIST) for acellular pertussis vaccines: State of the science and the path forward. (24394373)
2014
3
Prevalence and molecular characterization of pertactin-deficient Bordetella pertussis in the US. (24256623)
2013
4
Genome Sequences of 28 Bordetella pertussis U.S. Outbreak Strains Dating from 2010 to 2012. (24356839)
2013
5
Measles and pertussis outbreaks: an important role for travel clinics. (23928029)
2013
6
An open-label randomized clinical trial of prophylactic paracetamol coadministered with 7-valent pneumococcal conjugate vaccine and hexavalent diphtheria toxoid, tetanus toxoid, 3-component acellular pertussis, hepatitis B, inactivated polio virus, and Haemophilus influenzae type b vaccine. (23786774)
2013
7
Acute carotid dissection in an adult caused by pertussis. (23410686)
2013
8
Incidence of pertussis in patients of general practitioners in Poland. (23870166)
2013
9
Qualitative assessment of pertussis diagnostics in United States laboratories. (23587980)
2013
10
Tetanus, diphtheria, acellular pertussis vaccine during pregnancy: pregnancy and infant health outcomes. (23896191)
2013
11
Insertion sequences shared by Bordetella species and implications for the biological diagnosis of pertussis syndrome. (22886091)
2013
12
Antibody responses in Sweden to individual Bordetella pertussis fimbriae serotype 2 or 3 following immunization with whole cell or two- or five-component acellular pertussis vaccines and following pertussis disease and in children in 1997 and 2007. (24307240)
2013
13
Phase II and III Clinical Studies of Diphtheria-Tetanus-Acellular Pertussis Vaccine Containing Inactivated Polio Vaccine Derived from Sabin Strains (DTaP-sIPV). (23568174)
2013
14
ACOG Committee Opinion No. 566: Update on immunization and pregnancy: tetanus, diphtheria, and pertussis vaccination. (23812487)
2013
15
Combined DTP-HBV-HIB vaccine versus separately administered DTP-HBV and HIB vaccines for primary prevention of diphtheria, tetanus, pertussis, hepatitis B and Haemophilus influenzae B (HIB). (22513932)
2012
16
Towards selective inhibitors of adenylyl cyclase toxin from Bordetella pertussis. (22578665)
2012
17
Genotypic and phenotypic characterization of Bordetella pertussis strains used in different vaccine formulations in Latin America. (22471652)
2012
18
Adverse event reports after tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccines in pregnant women. (22727350)
2012
19
Pertussis protection diminishes 5 years after fifth dose of DTaP. (23362542)
2012
20
The incidence of pertussis hospitalizations among Japanese infants: excess hospitalizations and complications? (22008091)
2012
21
Barriers to early uptake of tetanus, diphtheria and acellular pertussis vaccine (Tdap) among adults-United States, 2005-2007. (21459173)
2011
22
Immunogenicity and safety of a combined diphtheria, tetanus, acellular pertussis, and inactivated poliovirus vaccine (DTaP-IPV) compared to separate administration of standalone DTaP and IPV vaccines: a randomized, controlled study in infants in the Republic of Korea. (21215828)
2011
23
The decline and resurgence of pertussis in the US. (22094341)
2011
24
Fast, antigen-saving multiplex immunoassay to determine levels and avidity of mouse serum antibodies to pertussis, diphtheria, and tetanus antigens. (21325488)
2011
25
Enhanced memory B-cell immune responses after a second acellular pertussis booster vaccination in children 9 years of age. (22064265)
2011
26
Combined, reduced-antigen content tetanus, diphtheria, and acellular pertussis vaccine (Boostrix): a review of its use as a single-dose booster immunization in individuals aged 10-64 years in the US. (19697967)
2009
27
Immunogenicity and reactogenicity of two diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated polio virus-Haemophilus influenzae type b vaccines administered at 3, 5 and 11-12 months of age. (18690013)
2009
28
The adenylate cyclase toxins of Bacillus anthracis and Bordetella pertussis promote Th2 cell development by shaping T cell antigen receptor signaling. (19266022)
2009
29
Licensure of a diphtheria and tetanus toxoids and acellular pertussis adsorbed, inactivated poliovirus, and haemophilus B conjugate vaccine and guidance for use in infants and children. (18830213)
2008
30
Prophylactic use of acetaminophen in children vaccinated with diphtheria-tetanus-pertussis. (18661769)
2008
31
Licensure of a diphtheria and tetanus toxoids and acellular pertussis adsorbed and inactivated poliovirus vaccine and guidance for use as a booster dose. (18830212)
2008
32
TIMP-1 inhibits apoptosis in breast carcinoma cells via a pathway involving pertussis toxin-sensitive G protein and c-Src. (14652000)
2003
33
Bordetella pertussis protein pertactin induces type-specific antibodies: one possible explanation for the emergence of antigenic variants? (12695998)
2003
34
Pertussis toxin-insensitive activation of the heterotrimeric G-proteins Gi/Go by the NG108-15 G-protein activator. (12426323)
2002
35
Effect of acellular pertussis vaccine on the development of allergic sensitization to environmental allergens in adults. (10629468)
2000
36
Signalling and cellular specificity of airway nitric oxide production in pertussis. (11207540)
1999
37
Pertussis toxin-sensitive G proteins as mediators of the signal transduction pathways activated by cytomegalovirus infection of smooth muscle cells. (9329970)
1997
38
Intrathecal pertussis toxin produces hyperalgesia and allodynia in mice. (9150297)
1997
39
Pertussis toxin- and PMA-insensitive calcium mobilization by sphingosine in CFPAC-1 cells: evidence for a phosphatidic acid-dependent mechanism. (9296526)
1997
40
C3a and C5a are chemotaxins for human mast cells and act through distinct receptors via a pertussis toxin-sensitive signal transduction pathway. (8759757)
1996
41
Mechanism of stress-induced attenuation of the testicular response to gonadotropin: possible involvement of testicular opioids, a pertussis toxin-sensitive G-protein, and phosphodiesterase. (8833736)
1996
42
Effect of cholera toxin and pertussis toxin on the growth of A431 cells: kinetics of cyclic AMP and inositol trisphosphate in toxin-treated cells. (7607603)
1995
43
Binding of FimD on Bordetella pertussis to very late antigen-5 on monocytes activates complement receptor type 3 via protein tyrosine kinases. (7561105)
1995
44
Insulin-stimulated phosphatidylcholine hydrolysis, diacylglycerol/protein kinase C signalling, and hexose transport in pertussis toxin-treated BC3H-1 myocytes. (7857772)
1994
45
Molecular characterization of the in vitro activation of pertussis toxin by ATP. (8509398)
1993
46
Pertussis toxin sensitive G-protein coupling of HDL receptor to phospholipase C in human platelets. (1333103)
1992
47
Participation of lipid peroxidation in rat pertussis vaccine pleurisy. III. Thiobarbituric acid (TBA) reactant and lysosomal enzyme. (2054877)
1991
48
Characterization of the human gene for Gx alpha, a pertussis toxin- insensitive regulatory GTP-binding protein. (2115889)
1990
49
GTP-binding proteins in human platelet membranes serving as the specific substrate of islet-activating protein, pertussis toxin. (3139448)
1988
50
Action of phenylbutazone, cyclophosphamide and prednacinolone on pleurisy due to Bordetella pertussis hypersensitivity in the rat. (216327)
1978

Genetic Variations for Pertussis

Expression for genes affiliated with Pertussis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pertussis

Search GEO for disease gene expression data for Pertussis.

Pathways for genes affiliated with Pertussis

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 12EMD Millipore, 52QIAGEN
See all sources

Pathways related to Pertussis according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.5CNR1, GNA14, GNAI1, GNAZ, OR4D2, P2RY4
2
Hide members
11.2CNR1, CNR2, GNAI1, P2RY13, P2RY4, FFAR3
3
Hide members
11.1CALML5, CALML3, CALML6, GNAI1, CNR1
4
Development Endothelin-1/EDNRA signaling
Hide members
11.1CALML6, CALML5, CALML3, GNAZ, GNAI1
511.1GNAI1, CALML5, CALML6, PYCARD, CALML3
6
Hide members
11.0CNR1, GNAZ, GNAI1, GNA14
711.0CALML5, CALML3, GNA14, CALML6
811.0CALML3, GNAI1, CALML6, CALML5
9
Hide members
11.0CALML3, CALML5, GNAI1, CALML6
10
Hide members
11.0CALML3, CALML6, CALML5, GNAI1
11
Hide members
11.0CALML3, CALML5, GNAI1, CALML6
12
Hide members
11.0CALML6, GNAI1, CALML5, CALML3
1310.8GNAI1, GNAZ, GNA14
14
Signal transduction cAMP signaling
Hide members
10.8GNA14, GNAZ, GNAI1
15
Hide members
10.8GNA14, GNAZ, GNAI1
16
Hide members
10.8GNAZ, GNA14, GNAI1
1710.8GNAZ, GNAI1, GNA14
1810.8GNAZ, GNAI1, GNA14
19
Hide members
10.8GNA14, GNAZ, GNAI1
2010.8GNAZ, GNAI1, P2RY13
21
Hide members
10.8CALML5, CALML3, CALML6
2210.8CALML3, CALML5, CALML6
23
Hide members
10.8CALML5, CALML6, CALML3
24
Hide members
10.7CNR2, CNR1
25
Hide members
10.7GNAI1, GNAZ
26
Hide members
10.7P2RY13, P2RY4

Compounds for genes affiliated with Pertussis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Pertussis according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
1calcium45 50 11 2415.1CCL15, CALML3, CALML5, GNAI1, GNAZ, OR4D2
2gtp45 2912.4P2RY4, CNR2, OR4D2, GNAZ, GNAI1
3delta9-tetrahydrocannabinol4511.2CNR2, CNR1, GNAI1
4gallein6011.2GNAZ, GNAI1, GNA14
5g-protein antagonist peptide6011.2GNAZ, GNAI1, GNA14
6suramin hexasodium salt6011.2GNA14, GNAI1, GNAZ
7pertussis toxin6011.2GNAZ, GNAI1, GNA14
88-bromo-cgmp, sodium salt6011.2GNAZ, GNAI1, GNA14
9nabilone45 1112.1CNR1, CNR2
10[3h]win55212-22911.1CNR1, CNR2
11am63045 2912.1CNR1, CNR2
12sr14452845 2912.1CNR1, CNR2
13cannabinol45 2912.1CNR1, CNR2
14[3h]cp559402911.1CNR1, CNR2
15cp5594029 4512.1CNR1, CNR2
16win 55212 24511.1CNR1, CNR2
17win55212-22911.1CNR1, CNR2
18am25129 4512.0CNR1, CNR2
19marijuana4511.0CNR2, CNR1
20hu-2102911.0CNR2, CNR1
21echinacea4511.0CNR1, CNR2
22cannabidiol29 4512.0CNR1, CNR2
23δ9-tetrahydrocannabinol2911.0CNR2, CNR1
24Dronabinol1111.0CNR2, CNR1
25alpha,beta-methyleneadenosine 5-triphosphate trisodium salt6011.0P2RY13, P2RY4
26mrs 2179 tetrasodium salt6011.0P2RY4, P2RY13
27utpgammas trisodium salt6010.9P2RY4, P2RY13
28mrs 23656010.9P2RY13, P2RY4
29mrs 2500 tetraammonium salt6010.9P2RY13, P2RY4
302-arachidonoylglycerol45 2911.9CNR1, CNR2
31capsazepine45 60 2912.8CNR1, CNR2
32rimonabant45 29 1112.8CNR1, CNR2
33monoacylglycerol4510.7CNR2, CNR1
34ppads45 2911.7P2RY4, P2RY13
35pyrazole45 1111.6CNR1, CNR2
36quinpirole45 2911.4CNR1, GNAI1

GO Terms for genes affiliated with Pertussis

Sources:
16Gene Ontology
See all sources

Cellular components related to Pertussis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.6ART1, OR4D2, GNAZ, GNAI1, GNA14, FFAR3
2extrinsic to internal side of plasma membraneGO:03123410.9CNR2, GNAZ, GNAI1, GNA14
3heterotrimeric G-protein complexGO:00583410.8GNAZ, GNAI1, GNA14

Biological processes related to Pertussis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1adenylate cyclase-modulating G-protein coupled receptor signaling pathwayGO:00718810.8CNR1, GNAZ, GNA14
2negative regulation of nitric-oxide synthase activityGO:05100110.7CNR2, CNR1
3negative regulation of mast cell activationGO:03300410.6CNR2, CNR1
4negative regulation of action potentialGO:04575910.4CNR2, CNR1

Molecular functions related to Pertussis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1G-protein beta/gamma-subunit complex bindingGO:03168310.8GNAZ, GNAI1, GNA14
2G-protein coupled purinergic nucleotide receptor activityGO:04502810.7P2RY4, P2RY13
3cannabinoid receptor activityGO:00494910.6CNR2, CNR1
4G-protein coupled serotonin receptor bindingGO:03182110.4GNAZ, GNAI1

Products for genes affiliated with Pertussis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pertussis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet