MCID: PRT037
MIFTS: 62

Pertussis malady

Rare diseases, Infectious diseases, Respiratory diseases categories
Download this MalaCard

Summaries for Pertussis

About this section


Fully expand this MalaCard
MedlinePlus:33 Whooping cough is an infectious bacterial disease that causes uncontrollable coughing. the name comes from the noise you make when you take a breath after you cough. you may have choking spells or may cough so hard that you vomit. anyone can get whooping cough, but it is more common in infants and children. it's especially dangerous for infants. the coughing spells can be so bad that it is hard for infants to eat, drink, or breathe. to make a diagnosis, your doctor may do a physical exam, blood tests, chest x-rays, or nose or throat cultures. before there was a vaccine, whooping cough was one of the most common childhood diseases and a major cause of childhood deaths in the u.s. now most cases are prevented by vaccines. if you have whooping cough, treatment with antibiotics may help if given early. centers for disease control and prevention

MalaCards based summary: Pertussis, also known as whooping cough, is related to cholera and diphtheria. An important gene associated with Pertussis is CNR2 (cannabinoid receptor 2 (macrophage)), and among its related pathways are Neuropeptides signaling through G protein alpha i and G protein alpha q and LPA receptor mediated events. The drugs guaifenesin and erythromycin pwdr and the compounds nabilone and [3h]win55212-2 have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract, testes and t cells.

Disease Ontology:8 A commensal bacterial infectious disease that results in inflammation located in respiratory tract, has material basis in bordetella pertussis, or has material basis in bordetella parapertussis, which produce toxins that paralyze the cilia of the respiratory epithelial cells. the infection is characterized by a prolonged, high-pitched, deeply indrawn breath (whoop).

Wikipedia:65 Pertussis?commonly called whooping cough (/?wu?p??/, /?hu?p??/, or /?hwu?p?? k?f/)?is a highly... more...

Aliases & Classifications for Pertussis

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 62UMLS, 33MedlinePlus, 34MeSH, 57SNOMED-CT, 26ICD10 via Orphanet, 63UMLS via Orphanet, 35MESH via Orphanet, 25ICD10
See all sources

Pertussis, Aliases & Descriptions:

Name: Pertussis 8 42 10 48 62
Whooping Cough 8 42 48 33 62
Whooping Cough Due to Unspecified Organism 62
Bordetella Pertussis Infection 42
 
Bordetella Infections 62
Bordetella Infection 8
Wc - Whooping Cough 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases
Anatomical: Respiratory diseases


External Ids:

Disease Ontology8 DOID:1116
MeSH34 D001885
ICD10 via Orphanet26 A37.0, A37.1, A37.8 A37.9, more
SNOMED-CT57 26484003
UMLS via Orphanet63 C0043167
MESH via Orphanet35 D014917

Related Diseases for Pertussis

About this section

Diseases related to Pertussis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1cholera30.8ART1, CNR1, GNAI1
2diphtheria11.1
3tetanus11.1
4influenza10.8
5haemophilus influenzae10.8
6hepatitis10.7
7hepatitis b10.7
8poliomyelitis10.6
9scarlet fever10.6
10measles10.4
11chickenpox10.4
12mumps10.3
13pleurisy10.3
14rubella10.3
15neuronitis10.3
16neuroblastoma10.3
17endotheliitis10.3
18hiv-110.2
19typhoid fever10.2
20leprosy10.2
21smallpox10.2
22syphilis10.2
23yaws10.2
24pneumonia10.2
25eating disorder10.1CNR1, HCRTR1
26asthma10.1
27hypertrophic pyloric stenosis10.1
28hemolytic-uremic syndrome10.1
29hepatitis a10.1
30nasopharyngitis10.1
31paralytic poliomyelitis10.1
32pyloric stenosis10.1
33retinitis10.1
34orchitis10.0
35myelitis10.0
36leukemoid reaction10.0
37melanoma10.0
38pancreatitis10.0
39tuberculosis10.0
40allergic encephalomyelitis10.0
41parainfluenza virus type 310.0
42febrile seizures10.0
43atopy10.0
44blindness10.0
45alzheimer's disease9.9
46asphyxia neonatorum9.9
47cervical cancer9.9
48cystic fibrosis9.9
49hemolytic anemia9.9
50leukemia9.9

Graphical network of the top 20 diseases related to Pertussis:



Diseases related to pertussis

Symptoms for Pertussis

About this section

Drugs & Therapeutics for Pertussis

About this section

Drug clinical trials:

Search ClinicalTrials for Pertussis

Search NIH Clinical Center for Pertussis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Pertussis

About this section

Anatomical Context for Pertussis

About this section

MalaCards organs/tissues related to Pertussis:

32
Testes, T cells, Monocytes, Neutrophil, Endothelial, Heart, Brain, Smooth muscle, Lung, Adipocyte, B cells, Breast, Pituitary, Lymph node, Thymus, Ovary, Trachea, Pancreatic islet, Whole blood

FMA organs/tissues related to Pertussis:

14
Respiratory tract

Animal Models for Pertussis or affiliated genes

About this section

Publications for Pertussis

About this section

Articles related to Pertussis:

(show top 50)    (show all 997)
idTitleAuthorsYear
1
Sources of Pertussis Infection in Young Babies From SA8o Paulo State, Brazil. (25386966)
2014
2
Management and prevention of pertussis infection in neonates. (25371322)
2014
3
Vaccination with tetanus, diphtheria, and acellular pertussis vaccine of pregnant women enrolled in Medicaid--Michigan, 2011-2013. (25254561)
2014
4
Health care worker exposures to pertussis: missed opportunities for prevention. (24344101)
2014
5
The "how" of polymerase chain reaction testing for Bordetella pertussis depends on the "why". (23087394)
2013
6
Combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Hemophilus influenzae type b vaccine; Infanrixa8c hexa: Twelve years of experience in Italy. (24004825)
2013
7
Identification of biomarkers to detect residual pertussis toxin using microarray analysis of dendritic cells. (24055089)
2013
8
A proteoliposome formulation derived from Bordetella pertussis induces protection in two murine challenge models. (23458724)
2013
9
Prevalence and molecular characterization of pertactin-deficient Bordetella pertussis in the US. (24256623)
2013
10
Bordetella holmesii and pertussis diagnosis: authors' reply. (23842047)
2013
11
Attitude of Italian physicians toward pertussis diagnosis. (23732898)
2013
12
Cost-effectiveness analysis of a pertussis vaccination programme for Japan considering intergenerational infection. (23570987)
2013
13
Tdap vaccination during pregnancy to reduce pertussis infection in young infants. (23673584)
2013
14
Genome Sequences of 28 Bordetella pertussis U.S. Outbreak Strains Dating from 2010 to 2012. (24356839)
2013
15
Pertussis vaccination of health care workers: ACOEM medical center occupational health section task force on pertussis vaccination of health care workers. (24013658)
2013
16
Randomized, controlled, multicenter study of the immunogenicity and safety of a fully liquid combination diphtheria-tetanus toxoid-five-component acellular pertussis (DTaP5), inactivated poliovirus (IPV), and haemophilus influenzae type b (Hib) vaccine compared with a DTaP3-IPV/Hib vaccine administered at 3, 5, and 12 months of age. (23966556)
2013
17
Pertussis resurgence: waning immunity and pathogen adaptation - two sides of the same coin. (23406868)
2013
18
Leukocyte transcript alterations in West-African girls following a booster vaccination with diphtheria-tetanus-pertussis vaccine. (23668887)
2013
19
Should acellular pertussis vaccine be recommended to healthcare professionals? (23842996)
2013
20
California pertussis epidemic, 2010. (22819634)
2012
21
Pertussis cases rise 10-fold among older children and adults in England and Wales. (22826583)
2012
22
The immunoregulatory role of CD4a8_ FoxP3a8_ CD25a8> regulatory T cells in lungs of mice infected with Bordetella pertussis. (22211712)
2012
23
Number and order of whole cell pertussis vaccines in infancy and disease protection. (22851107)
2012
24
BapC autotransporter protein of Bordetella pertussis is an adhesion factor. (22052409)
2012
25
The seroepidemiology of pertussis in NSW: fluctuating immunity profiles related to changes in vaccination schedules. (22243639)
2011
26
Updated recommendations for use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine (Tdap) in pregnant women and persons who have or anticipate having close contact with an infant aged <12 months --- Advisory Committee on Immunization Practices (ACIP), 2011. (22012116)
2011
27
Safety and immunogenicity of three different formulations of a liquid hexavalent diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae b conjugate-hepatitis B vaccine at 2, 4, 6 and 12-14 months of age. (21134456)
2011
28
The effect of vitamin A supplementation and diphtheria-tetanus-pertussis vaccination on parasitaemia in an experimental murine malaria model. (21105844)
2011
29
Combination of pneumococcal surface protein A (PspA) with whole cell pertussis vaccine increases protection against pneumococcal challenge in mice. (20523738)
2010
30
Determinants of the uptake of the full dose of diphtheria-pertussis-tetanus vaccines (DPT3) in Northern Nigeria: a multilevel analysis. (18607704)
2009
31
A simple and rapid method for quantifying 2-phenoxyethanol (2-PE) in Diphtheria, Tetanus and w-Pertussis (DTwP) vaccine. (17728142)
2008
32
An adolescent-adult formulation tetanus and diptheria toxoids adsorbed combined with acellular pertussis vaccine has comparable immunogenicity but less reactogenicity in children 4-6 years of age than a pediatric formulation acellular pertussis vaccine and diphtheria and tetanus toxoids adsorbed combined with inactivated poliomyelitis vaccine. (17045366)
2007
33
The immunological response of Thai infants to haemophilus influenzae type B polysaccharide-tetanus conjugate vaccine co-administered in the same syringe with locally produced diphtheria-tetanus-pertussis vaccine. (17710973)
2007
34
Comparison of the relative efficacy and potency of mu-opioid agonists to activate Galpha(i/o) proteins containing a pertussis toxin-insensitive mutation. (16436499)
2006
35
TIMP-1 inhibits apoptosis in breast carcinoma cells via a pathway involving pertussis toxin-sensitive G protein and c-Src. (14652000)
2003
36
Differential effects of genistein on apoptosis induced by fluoride and pertussis toxin in human and rat pancreatic islets and RINm5F cells. (11786381)
2002
37
Critical involvement of p38 MAP kinase in pertussis toxin-induced cytoskeletal reorganization and lung permeability. (12087068)
2002
38
Infantile hypertrophic pyloric stenosis after pertussis prophylaxis with erythromcyin: a case review and cohort study. (10609814)
1999
39
Interferon-inducible protein-10 and lymphotactin induce the chemotaxis and mobilization of intracellular calcium in natural killer cells through pertussis toxin-sensitive and -insensitive heterotrimeric G-proteins. (9271361)
1997
40
The growth-promoting effect of low-density lipoprotein may Be mediated by a pertussis toxin-sensitive mitogen-activated protein kinase pathway. (9281600)
1997
41
A somatostatin receptor inhibits noradrenaline release from chick sympathetic neurons through pertussis toxin-sensitive mechanisms: comparison with the action of alpha 2-adrenoceptors. (8783273)
1996
42
Involvement of pertussis toxin-sensitive mechanism in retinoic acid-induced differentiation of human leukemic HL-60 cells. (7775389)
1995
43
Effects of pertussis and cholera toxin on the interferon-gamma stimulated immunocytochemical staining of ICAM-1 and inositol phosphate formation in a human renal carcinoma cell line. (7908588)
1993
44
Oxytocin-stimulated phosphoinositide hydrolysis in human myometrial cells: involvement of pertussis toxin-sensitive and -insensitive G-proteins. (8386215)
1993
45
Activation of phospholipase C by heat shock requires GTP analogs and is resistant to pertussis toxin. (8314854)
1993
46
Parainfluenza virus type 3 and pertussis syndrome. (8244477)
1993
47
Inversion of Ca2+ current modulation during recovery of neuroblastoma cells from pertussis toxin pretreatment. (7902295)
1993
48
Immunodetectable levels of the inhibitory guanine nucleotide-binding regulatory proteins in failing human heart: discordance with measurements of adenylate cyclase activity and levels of pertussis toxin substrate. (1942080)
1991
49
Sequence analysis of cDNA and genomic DNA for a putative pertussis toxin-insensitive guanine nucleotide-binding regulatory protein alpha subunit. (2456569)
1988
50
Action of various drugs with anti-inflammatory or anti-rheumatic properties on pleurisy due to Bordetella pertussis hypersensitivity in the rat. (232922)
1979

Variations for Pertussis

About this section

Expression for genes affiliated with Pertussis

About this section
Expression patterns in normal tissues for genes affiliated with Pertussis

Search GEO for disease gene expression data for Pertussis.

Pathways for genes affiliated with Pertussis

About this section

Pathways related to Pertussis according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Peptide GPCRs37
9.7GNAZ, GNAI1, HCRTR1
29.6GNA14, GNAZ, GNAI1
39.6GNAI1, GNAZ, GNA14
4
Show member pathways
S1P2 pathway37
S1P4 pathway37
S1P5 pathway37
S1P1 pathway37
Sphingosine 1-phosphate (S1P) pathway37
9.6GNA14, GNAZ, GNAI1
5
Show member pathways
D-myo-inositol-5-phosphate metabolism37
superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism37
D-myo-inositol (1,4,5)-trisphosphate degradation37
superpathway of inositol phosphate compounds37
1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)37
D-myo-inositol (1,4,5)-trisphosphate biosynthesis37
myo-inositol biosynthesis37
1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)37
D-myo-inositol (1,3,4)-trisphosphate biosynthesis37
9.4CALML3, CALML5, CALML6
6
Show member pathways
9.4CALML6, CALML5, CALML3
7
Show member pathways
Alzheimers Disease37
9.4CALML6, CALML5, CALML3
8
Show member pathways
9.4CALML6, CALML5, CALML3
9
Show member pathways
Development Beta adrenergic receptors regulation of ERK60
G protein signaling G Protein alpha s signaling cascades60
G protein signaling G Protein beta gamma signaling cascades60
9.3GNAI1, GNAZ, GNG8
10
Show member pathways
9.3GNG8, GNAZ, GNAI1
11
Show member pathways
Development A1 receptor signaling60
G protein signaling G Protein alpha q signaling cascades60
9.3GNAI1, GNAZ, GNG8
129.3GNAI1, GNAZ, GNG8
13
Show member pathways
G protein signaling G Protein alpha 12 signaling pathway60
9.3GNG8, GNAZ, GNAI1
14
Show member pathways
9.3GNG8, GNAZ, GNAI1
15
Show member pathways
9.2GNA14, GNG8, GNAI1
169.2GNA14, CALML3, CALML5, CALML6
17
Show member pathways
9.2CALML6, CALML5, CALML3, OR4D2
18
Show member pathways
9.1CALML6, CALML5, CALML3, GNAI1
19
Show member pathways
9.1GNAI1, CALML3, CALML5, CALML6
209.1GNAI1, CALML3, CALML5, CALML6
21
Show member pathways
9.1GNAI1, CALML3, CALML5, CALML6
22
Show member pathways
9.1GNAI1, CALML3, CALML5, CALML6
23
Show member pathways
9.1GNAI1, CALML3, CALML5, CALML6
249.1GNAI1, CALML3, CALML5, CALML6
25
Show member pathways
9.0GNA14, GNG8, GNAZ, GNAI1
26
Show member pathways
Apoptosis and survival BAD phosphorylation60
Development Alpha 2 adrenergic receptor activation of ERK60
Chemotaxis CXCR4 signaling pathway60
9.0GNA14, GNG8, GNAZ, GNAI1
27
Show member pathways
Signal transduction cAMP signaling60
9.0GNA14, GNG8, GNAZ, GNAI1
28
Show member pathways
9.0GNA14, GNG8, GNAZ, GNAI1
29
Show member pathways
9.0GNAI1, GNAZ, GNG8, GNA14
30
Show member pathways
9.0GNAI1, GNAZ, GNG8, GNA14
31
Show member pathways
9.0GNAI1, GNAZ, GNG8, GNA14
32
Show member pathways
Cytoskeleton remodeling Reverse signaling by ephrin B60
9.0GNAI1, GNAZ, GNG8, GNA14
33
Show member pathways
9.0GNAI1, GNAZ, GNG8, GNA14
34
Show member pathways
9.0GNAI1, GNAZ, GNG8, GNA14
35
Show member pathways
9.0GNAI1, GNAZ, GNG8, GNA14
36
Show member pathways
9.0GNAI1, GNAZ, GNG8, GNA14
379.0GNAI1, GNAZ, GNG8, GNA14
38
Show member pathways
9.0GNAI1, GNAZ, GNG8, GNA14
39
Show member pathways
8.9HCRTR1, GNG8, GNA14, FFAR3
40
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
8.8CALML6, CALML5, CALML3, GNAZ, GNAI1
41
Show member pathways
8.8GNAI1, GNAZ, GNG8, GNA14, CNR1
42
Show member pathways
8.8GNAI1, GNG8, GNA14, CCL15
43
Show member pathways
8.5GNAI1, GNAZ, GNG8, GNA14, CCL15
44
Show member pathways
8.5GNAI1, GNAZ, GNG8, GNA14, CCL15
45
Show member pathways
8.4GNAI1, GNG8, CALML3, CALML5, CALML6
46
Show member pathways
Calcium Regulation in the Cardiac Cell37
8.4GNG8, GNAZ, GNAI1, GUCA2B
47
Show member pathways
8.2GNAI1, GNG8, CNR1, CALML3, CALML5, CALML6
48
Show member pathways
8.2CALML6, CALML5, CALML3, CNR1, GNG8, GNAI1
49
Show member pathways
8.1HCRTR1, GNAI1, GNAZ, GNG8, FFAR3, CNR1
50
Show member pathways
7.6HCRTR1, GNAI1, GNAZ, GNG8, GNA14, FFAR3

Compounds for genes affiliated with Pertussis

About this section

Compounds related to Pertussis according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1nabilone44 1111.5CNR1, CNR2
2[3h]win55212-22810.5CNR1, CNR2
3am63044 2811.5CNR1, CNR2
4sr14452844 2811.5CNR1, CNR2
5[3h]cp559402810.5CNR1, CNR2
6win 55212 24410.5CNR1, CNR2
7cp5594044 2811.5CNR1, CNR2
8cannabinol44 2811.4CNR1, CNR2
9win55212-22810.4CNR2, CNR1
10am25144 2811.4CNR2, CNR1
11hu-2102810.4CNR2, CNR1
12marijuana4410.4CNR2, CNR1
13echinacea4410.4CNR1, CNR2
14cannabidiol28 4411.4CNR1, CNR2
15delta9-tetrahydrocannabinol2810.4CNR2, CNR1
162-arachidonoylglycerol44 2811.4CNR2, CNR1
17rimonabant44 28 1112.3CNR1, CNR2
18capsazepine61 44 2812.3CNR1, CNR2
19pyrazole44 1111.3CNR2, CNR1
20monoacylglycerol4410.1CNR1, CNR2
21delta9-tetrahydrocannabinol4410.1GNAI1, CNR1, CNR2
22quinpirole44 2811.0CNR1, GNAI1
23carbon4410.0ART1, CNR2, CNR1
24guanosine 5-o-(3-thiotriphosphate)449.8OR4D2, GNAI1
25gtp44 2810.6GNAI1, GNAZ, OR4D2, CNR2
26gdp449.6OR4D2, GNAZ, GNAI1
27pertussis toxin619.4GNA14, GNG8, GNAZ, GNAI1
28gallein619.4GNA14, GNG8, GNAZ, GNAI1
29g-protein antagonist peptide619.4GNA14, GNG8, GNAZ, GNAI1
30suramin hexasodium salt619.4GNAI1, GNAZ, GNG8, GNA14
318-bromo-cgmp, sodium salt619.4GNA14, GNG8, GNAZ, GNAI1
32adenylate449.4HCRTR1, GNAI1, CNR1, CNR2
33Guanosine monophosphate249.4GNAI1, GNAZ, GNG8, GNA14
34Guanosine diphosphate249.3GNAI1, GNAZ, GNG8, GNA14
35dopamine44 28 24 1112.3HCRTR1, GNAI1, CNR1, RABEP2
36cgmp44 2810.3GNAZ, GNAI1, GUCA2B
37cyclic amp44 2410.1CNR2, CNR1, OR4D2, GNAI1
38Guanosine triphosphate248.8GNAI1, GNAZ, GNG8, GNA14, RABEP2
39calcium44 50 24 1110.7HCRTR1, GNAI1, GNAZ, FFAR3, OR4D2, CCL15

GO Terms for genes affiliated with Pertussis

About this section

Cellular components related to Pertussis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extrinsic component of cytoplasmic side of plasma membraneGO:0312349.3GNAI1, GNAZ, GNA14, CNR2
2integral component of plasma membraneGO:0058879.1FFAR3, CNR1, CNR2, ART1, HCRTR1
3heterotrimeric G-protein complexGO:0058349.0GNA14, GNG8, GNAZ, GNAI1
4plasma membraneGO:0058866.7HCRTR1, GPR84, GNAI1, GNAZ, GNG8, GNA14

Biological processes related to Pertussis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of action potentialGO:04575910.2CNR1, CNR2
2negative regulation of mast cell activationGO:03300410.2CNR1, CNR2
3negative regulation of nitric-oxide synthase activityGO:05100110.1CNR2, CNR1
4adenylate cyclase-modulating G-protein coupled receptor signaling pathwayGO:00718810.0CNR1, GNA14, GNAZ
5adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:0071939.9GNAZ, GNAI1
6G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.8CNR2, CNR1
7negative regulation of blood pressureGO:0457769.4CNR1, GUCA2B
8G-protein coupled receptor signaling pathwayGO:0071868.7GNAI1, GNAZ, GNG8, FFAR3

Molecular functions related to Pertussis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cannabinoid receptor activityGO:00494910.1CNR2, CNR1
2G-protein coupled serotonin receptor bindingGO:0318219.9GNAZ, GNAI1
3G-protein beta/gamma-subunit complex bindingGO:0316839.7GNA14, GNAZ, GNAI1
4G-protein coupled receptor activityGO:0049309.1OR4D2, FFAR3, GPR84, HCRTR1
5GTPase activityGO:0039248.9GNAI1, GNAZ, GNG8, GNA14
6signal transducer activityGO:0048718.7GNAI1, GNAZ, GNG8, GNA14

Products for genes affiliated with Pertussis

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Pertussis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet