MCID: PRT037
MIFTS: 64

Pertussis malady

Infectious diseases category

Summaries for Pertussis

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8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Whooping cough is an infectious bacterial disease that causes uncontrollable coughing. the name comes from the noise you make when you take a breath after you cough. you may have choking spells or may cough so hard that you vomit. anyone can get whooping cough, but it is more common in infants and children. it's especially dangerous for infants. the coughing spells can be so bad that it is hard for infants to eat, drink, or breathe. to make a diagnosis, your doctor may do a physical exam, blood tests, chest x-rays, or nose or throat cultures. before there was a vaccine, whooping cough was one of the most common childhood diseases and a major cause of childhood deaths in the u.s. now most cases are prevented by vaccines. if you have whooping cough, treatment with antibiotics may help if given early. centers for disease control and prevention

MalaCards: Pertussis, also known as whooping cough, is related to alzheimer's disease and diphtheria. An important gene associated with Pertussis is CNR2 (cannabinoid receptor 2 (macrophage)), and among its related pathways are Signaling by GPCR and Class A/1 (Rhodopsin-like receptors). The drugs erythromycin pwdr and guaifenesin and the compounds calcium and gtp have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract, testes and t cells.

Disease Ontology:8 A commensal bacterial infectious disease that results in inflammation located in respiratory tract, has material basis in bordetella pertussis, or has material basis in bordetella parapertussis, which produce toxins that paralyze the cilia of the respiratory epithelial cells. the infection is characterized by a prolonged, high-pitched, deeply indrawn breath (whoop).

CDC:3 Pertussis, also known as whooping cough, is a highly contagious respiratory disease. It is caused by the bacterium Bordetella pertussis.

Wikipedia:63 Pertussis — commonly called whooping cough (/ˈwuːpɪŋ/, /ˈhuːpɪŋ/, or /ˈhwuːpɪŋ kɒf/) —... more...

Aliases & Classifications for Pertussis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 33MedlinePlus, 56SNOMED-CT, 34MeSH, 26ICD10 via Orphanet, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

pertussis 8 42 10 48 60
whooping cough 8 42 48 33
whooping cough due to unspecified organism 60
bordetella pertussis infection 42
bordetella infections 60
bordetella infection 8
wc - whooping cough 8


External Ids:

Disease Ontology8 DOID:1116
MeSH34 D001885
ICD10 via Orphanet26 A37.1, A37.0, A37.8 A37.9, more
MESH via Orphanet35 D014917
SNOMED-CT56 26484003
SNOMED-CT via Orphanet57 27836007
UMLS via Orphanet61 C0043167

Related Diseases for Pertussis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Pertussis:



Diseases related to pertussis

Clinical Features for Pertussis

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Drugs & Therapeutics for Pertussis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Pertussis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Pertussis

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Anatomical Context for Pertussis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Pertussis:

32
Testes, T cells, Monocytes, Endothelial, Heart, Lung, Smooth muscle, Brain, Adipocyte, B cells, Pituitary, Trachea, Pancreatic islet, Ovary, Breast, Thymus, Lymph node, Whole blood

FMA organs/tissues related to Pertussis:

14
Respiratory tract

Animal Models for Pertussis or affiliated genes

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Publications for Pertussis

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50PubMed
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Articles related to Pertussis:

(show top 50)    (show all 975)
idTitleAuthorsYear
1
Concomitant treatment with pertussis toxin plus temozolomide increases the survival of rats bearing intracerebral RG2 glioma. (24337403)
2014
2
Attenuated Bordetella pertussis Vaccine Protects against Respiratory Syncytial Virus Disease via an IL-17-Dependent Mechanism. (24261996)
2014
3
Tdap vaccination during pregnancy to reduce pertussis infection in young infants. (23673584)
2013
4
Pertussis toxin enhances colony organization of enzymatic-dissociated single human embryonic stem cells. (23075100)
2013
5
Development and validation of an Australian in-house anti-pertussis toxin IgG and IgA enzyme immunoassay. (23250035)
2013
6
Bordetella pertussis adenylate cyclase toxin translocation across a tethered lipid bilayer. (24297899)
2013
7
Critical pertussis in a young infant requiring mechanical ventilation. (23738154)
2013
8
Estimation of the underlying burden of pertussis in adolescents and adults in southern ontario, Canada. (24376767)
2013
9
Coping with a pertussis outbreak in Alamance County, North Carolina. (23530389)
2013
10
Functional deficits of pertussis-specific CD4+ T cells in infants compared to adults following DTaP vaccination. (22861368)
2012
11
The seroepidemiology of immunoglobulin G antibodies against pertussis toxin in China: a cross sectional study. (22892100)
2012
12
Dual mechanism of protection by live attenuated Bordetella pertussis BPZE1 against Bordetella bronchiseptica in mice. (22814407)
2012
13
Serologic evidence of pertussis infection in vaccinated Iranian children. (23390332)
2012
14
Increase in pertussis may be due to increased recognition and diagnosis. (22915721)
2012
15
Evaluation of an in vitro assay system as a potential alternative to current histamine sensitization test for acellular pertussis vaccines. (22890129)
2012
16
Estimation of household transmission rates of pertussis and the effect of cocooning vaccination strategies on infant pertussis. (23018969)
2012
17
Updated recommendations for use of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine in adults aged 65 years and older - Advisory Committee on Immunization Practices (ACIP), 2012. (22739778)
2012
18
Unexpectedly limited durability of immunity following acellular pertussis vaccination in preadolescents in a North American outbreak. (22871826)
2012
19
Feasibility of a cocoon strategy for the prevention of pertussis in Italy: a survey of prevention department healthcare providers. (22863911)
2012
20
Pseudobronchiectasis after pertussis and mycoplasma infection. (22855546)
2012
21
Comparative study of different sources of pertussis toxin (PT) as coating antigens in IgG anti-PT enzyme-linked immunosorbent assays. (22116688)
2012
22
Temporal trends in Bordetella pertussis populations, Denmark, 1949-2010. (22515990)
2012
23
Updated recommendations for use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis (Tdap) vaccine from the Advisory Committee on Immunization Practices, 2010. (21228763)
2011
24
Interactions between Bordetella pertussis and the complement inhibitor factor H. (21167605)
2011
25
Immunogenicity and reactogenicity of diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus and Haemophilus influenzae type B. (21621155)
2011
26
Antibodies to tetanus, diphtheria and pertussis among healthy adults vaccinated according to the French vaccination recommendations. (19221513)
2009
27
Cellular immunity as a potential cause of local reactions to booster vaccination with diphtheria and tetanus toxoids and acellular pertussis antigens. (19755930)
2009
28
An assessment of the safety of adolescent and adult tetanus-diphtheria-acellular pertussis (Tdap) vaccine, using active surveillance for adverse events in the Vaccine Safety Datalink. (19486957)
2009
29
Concomitant use of the 3-dose oral pentavalent rotavirus vaccine with a 3-dose primary vaccination course of a diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated polio-Haemophilus influenzae type b vaccine: immunogenicity and reactogenicity. (19209092)
2009
30
High seroprevalence of varicella, measles, mumps, rubella and pertussis antibodies in first-grade medical students. (18726668)
2008
31
Modulation of the NF-kappaB pathway by Bordetella pertussis filamentous hemagglutinin. (19043589)
2008
32
Development and validation of a multiplex immunoassay for the simultaneous determination of serum antibodies to Bordetella pertussis, diphtheria and tetanus. (18407287)
2008
33
Erythema multiforme due to diphtheria-pertussis-tetanus vaccine. (17542900)
2007
34
A fully liquid diphtheria-tetanus-five component acellular pertussis-inactivated poliomyelitis--Haemophilus influenzae type b conjugate vaccine: immunogenicity and safety of primary vaccination in Taiwanese infants. (16762579)
2007
35
One-year post-primary antibody persistence and booster immune response to a fully liquid five-component acellular pertussis, diphtheria, tetanus, inactivated poliomyelitis, Haemophilus influenzae type b conjugate vaccine. (17349809)
2007
36
Adverse events following booster doses of diphtheria-tetanus-inactivated poliovirus and acellular pertussis vaccines for 4-year-old children in The Netherlands. (17573165)
2007
37
Pertussis toxin promotes macrophage survival through inhibition of acid sphingomyelinase and activation of the phosphoinositide 3-kinase/protein kinase B pathway. (17521884)
2007
38
Comparison of the relative efficacy and potency of mu-opioid agonists to activate Galpha(i/o) proteins containing a pertussis toxin-insensitive mutation. (16436499)
2006
39
Induction of neutralizing antibodies and Th1-polarized and CD4-independent CD8+ T-cell responses following delivery of human immunodeficiency virus type 1 Tat protein by recombinant adenylate cyclase of Bordetella pertussis. (16014948)
2005
40
Immunogenicity and safety of a combined hepatitis A and B vaccine administered concomitantly with either a measles-mumps-rubella or a diphtheria-tetanus-acellular pertussis-inactivated poliomyelitis vaccine mixed with a Haemophilus influenzae type b conjugate vaccine in infants aged 12-18 months. (15780442)
2005
41
Role of nuclear factor-kappa B in the regulation of intercellular adhesion molecule 1 after infection of human bronchial epithelial cells by Bordetella pertussis. (12946329)
2003
42
Neurotoxic mechanisms triggered by Alzheimer's disease-linked mutant M146L presenilin 1: involvement of NO synthase via a novel pertussis toxin target. (11905990)
2002
43
Pertussis toxin-induced reversible encephalopathy dependent on monocyte chemoattractant protein-1 overexpression in mice. (12486156)
2002
44
Pertussis toxin-sensitive signal controls the trafficking of thymocytes across the corticomedullary junction in the thymus. (10229836)
1999
45
M-current suppression in PC12 cells by bradykinin is mediated by a pertussis toxin-insensitive G-protein and modulated by intracellular calcium. (8973818)
1996
46
Recombinant human eotaxin induces oxygen radical production, Ca(2+)-mobilization, actin reorganization, and CD11b upregulation in human eosinophils via a pertussis toxin-sensitive heterotrimeric guanine nucleotide-binding protein. (8874220)
1996
47
C3a activates the respiratory burst in human polymorphonuclear neutrophilic leukocytes via pertussis toxin-sensitive G-proteins. (8193368)
1994
48
Alpha 2A-adrenergic receptors activate protein kinase C in human platelets via a pertussis toxin-sensitive G-protein. (8313982)
1994
49
Immunodetectable levels of the inhibitory guanine nucleotide-binding regulatory proteins in failing human heart: discordance with measurements of adenylate cyclase activity and levels of pertussis toxin substrate. (1942080)
1991
50
Nucleotide exchange and cGMP phosphodiesterase activation by pertussis toxin inactivated transducin. (1661143)
1991

Genetic Variations for Pertussis

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Expression for genes affiliated with Pertussis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pertussis

Search GEO for disease gene expression data for Pertussis.

Pathways for genes affiliated with Pertussis

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 51QIAGEN
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Pathways related to Pertussis according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.5GNA14, GNAI1, GNAZ, OR4D2, FFAR3, CNR1
2
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11.2GNAI1, FFAR3, CNR1, CNR2, P2RY13, P2RY4
3
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11.1CALML3, CALML5, CALML6, GNAI1, CNR1
4
Development Endothelin-1/EDNRA signaling
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11.1CALML3, CALML5, CALML6, GNAI1, GNAZ
511.1GNAI1, CALML6, CALML5, CALML3, PYCARD
6
Hide members
11.0GNA14, GNAI1, GNAZ, CNR1
711.0CALML3, CALML5, CALML6, GNA14
811.0CALML3, CALML5, CALML6, GNAI1
9
Hide members
11.0CALML3, CALML5, CALML6, GNAI1
10
Hide members
11.0CALML3, CALML5, CALML6, GNAI1
11
Hide members
11.0CALML3, CALML5, CALML6, GNAI1
12
Hide members
11.0GNAI1, CALML6, CALML5, CALML3
1310.8GNAZ, GNAI1, GNA14
14
Hide members
10.8GNAZ, GNAI1, GNA14
1510.8GNAZ, GNAI1, GNA14
16
Hide members
10.8GNAZ, GNAI1, GNA14
1710.8GNA14, GNAI1, GNAZ
18
Signal transduction cAMP signaling
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10.8GNA14, GNAI1, GNAZ
19
Hide members
10.8GNA14, GNAI1, GNAZ
2010.8P2RY13, GNAZ, GNAI1
2110.8CALML3, CALML5, CALML6
22
Hide members
10.8CALML6, CALML5, CALML3
23
Hide members
10.8CALML3, CALML5, CALML6
24
Hide members
10.7CNR2, CNR1
25
Hide members
10.7GNAZ, GNAI1
26
Hide members
10.7P2RY4, P2RY13

Compounds for genes affiliated with Pertussis

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Pertussis according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2415.1CCL15, CALML3, CALML5, GNAI1, GNAZ, OR4D2
2gtp44 2812.4P2RY4, CNR2, OR4D2, GNAZ, GNAI1
3delta9-tetrahydrocannabinol4411.2CNR2, CNR1, GNAI1
4gallein5911.2GNAZ, GNAI1, GNA14
5g-protein antagonist peptide5911.2GNAZ, GNAI1, GNA14
6suramin hexasodium salt5911.2GNA14, GNAI1, GNAZ
7pertussis toxin5911.2GNAZ, GNAI1, GNA14
88-bromo-cgmp, sodium salt5911.2GNAZ, GNAI1, GNA14
9nabilone44 1112.1CNR1, CNR2
10[3h]win55212-22811.1CNR1, CNR2
11am63044 2812.1CNR1, CNR2
12sr14452844 2812.1CNR1, CNR2
13cannabinol44 2812.1CNR1, CNR2
14[3h]cp559402811.1CNR1, CNR2
15cp5594028 4412.1CNR1, CNR2
16win 55212 24411.1CNR1, CNR2
17win55212-22811.1CNR1, CNR2
18am25128 4412.0CNR1, CNR2
19marijuana4411.0CNR2, CNR1
20hu-2102811.0CNR2, CNR1
21echinacea4411.0CNR1, CNR2
22cannabidiol28 4412.0CNR1, CNR2
23δ9-tetrahydrocannabinol2811.0CNR2, CNR1
24Dronabinol1111.0CNR2, CNR1
25alpha,beta-methyleneadenosine 5-triphosphate trisodium salt5911.0P2RY13, P2RY4
26mrs 2179 tetrasodium salt5911.0P2RY4, P2RY13
27utpgammas trisodium salt5910.9P2RY4, P2RY13
28mrs 23655910.9P2RY13, P2RY4
29mrs 2500 tetraammonium salt5910.9P2RY13, P2RY4
302-arachidonoylglycerol44 2811.9CNR1, CNR2
31capsazepine44 59 2812.8CNR1, CNR2
32rimonabant44 28 1112.8CNR1, CNR2
33monoacylglycerol4410.7CNR2, CNR1
34ppads44 2811.7P2RY4, P2RY13
35pyrazole44 1111.6CNR1, CNR2
36quinpirole44 2811.4CNR1, GNAI1

GO Terms for genes affiliated with Pertussis

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16Gene Ontology
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Cellular components related to Pertussis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.6ART1, OR4D2, GNAZ, GNAI1, GNA14, FFAR3
2extrinsic to internal side of plasma membraneGO:03123410.9CNR2, GNAZ, GNAI1, GNA14
3heterotrimeric G-protein complexGO:00583410.8GNAZ, GNAI1, GNA14

Biological processes related to Pertussis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1adenylate cyclase-modulating G-protein coupled receptor signaling pathwayGO:00718810.8CNR1, GNAZ, GNA14
2negative regulation of nitric-oxide synthase activityGO:05100110.7CNR2, CNR1
3negative regulation of mast cell activationGO:03300410.6CNR2, CNR1
4negative regulation of action potentialGO:04575910.4CNR2, CNR1

Molecular functions related to Pertussis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1G-protein beta/gamma-subunit complex bindingGO:03168310.8GNAZ, GNAI1, GNA14
2G-protein coupled purinergic nucleotide receptor activityGO:04502810.7P2RY4, P2RY13
3cannabinoid receptor activityGO:00494910.6CNR2, CNR1
4G-protein coupled serotonin receptor bindingGO:03182110.4GNAZ, GNAI1

Products for genes affiliated with Pertussis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pertussis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet