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MCID: PRT037

Pertussis malady
10 drugs, 412 genes, 17 tissues, 748 related diseases, 28 phenotypes, 267 articles, clinical trials.

Summaries for Pertussis

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6Disease Ontology, 23MedlinePlus, 2CDC, 44Wikipedia, 22MalaCards
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MedlinePlus: Whooping cough is an infectious bacterial disease that causes uncontrollable coughing. the name comes from the noise you make when you take a breath after you cough. you may have choking spells or may cough so hard that you vomit. anyone can get whooping cough, but it is more common in infants and children. it's especially dangerous in infants. the coughing spells can be so bad that it is hard for infants to eat, drink or breathe. before there was a vaccine, whooping cough was one of the most common childhood diseases and a major cause of childhood deaths in the u.s. there are fewer cases today because there are both pertussis-only vaccines and combination vaccines for tetanus, diphtheria and pertussis. if you have whooping cough, treatment with antibiotics may help if given early. centers for disease control and prevention23

MalaCards: Pertussis, also known as whooping cough, is related to carcinoma and neuronitis. An important gene associated with Pertussis is GNAZ (guanine nucleotide binding protein (G protein), alpha z polypeptide), and among its related pathways are RAR-Gamma-RXR-Alpha Degradation and Immune response_Classical complement pathway. The drugs demeclocycline and erythromycin and the compounds lipid and cyclic amp have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract, lymph node and brain, and related mouse phenotypes are mortality/aging and homeostasis/metabolism.

Disease Ontology: A commensal bacterial infectious disease that results in inflammation located in respiratory tract, has material basis in bordetella pertussis, or has material basis in bordetella parapertussis, which produce toxins that paralyze the cilia of the respiratory epithelial cells. the infection is characterized by a prolonged, high-pitched, deeply indrawn breath (whoop).6

CDC: Pertussis, also known as whooping cough, is a highly contagious respiratory disease. It is caused by the bacterium Bordetella pertussis.2

Wikipedia: Pertussis — commonly called whooping cough (pron.: /ˈhuːpɪŋ kɒf/ or /ˈhwuːpɪŋ kɒf/) — is a...44 more...

Aliases & Descriptions for Pertussis

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2CDC, 6Disease Ontology, 30NIH Rare Diseases, 8DISEASES, 43UMLS, 23MedlinePlus, 24MeSH, 40SNOMED-CT
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Aliases & Descriptions:

pertussis 6 30 8 43
whooping cough 6 30 23
whooping cough due to unspecified organism 43
bordetella pertussis infection 30
bordetella infections 43
bordetella infection 6
wc - whooping cough 6

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SNOMED-CT40 26484003

Related Diseases for Pertussis

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13GeneCards, 14GeneDecks
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Diseases related to pertussis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 745)
idRelated DiseaseScoreTop Affiliating Genes
1carcinoma36.6PIK3CG, PI3, PDE4A, RELA, CNR1, CNR2
2neuronitis36.0PIK3CG, PDE4A, RELA, CNR1, CNR2, KISS1R
3cholera32.6PDE4A, CNR1, GCG, VIP, LPAR2, VDAC1
4immunodeficiency31.3SELL, VIP, MYD88, BMP6, BLZF1, PARP1
5insulinoma31.2PIK3CG, GCG, VIP, KCNJ6, KCNJ3, KCNJ5
6leukemia30.6PIK3CG, PDE4A, RELA, CNR1, CNR2, SELL
7pancreatitis29.7PIK3CG, PI3, PDE4A, RELA, CNR1, CNR2
8diphtheria28.9LPAR1, BOC, PARP1, LEP, LBR, ATP8A2
9neuroblastoma28.6PIK3CG, PDE4A, RELA, CNR1, VIP, LPAR1
10alzheimer's disease27.6PIK3CG, PDE4A, CNR1, CNR2, SFTPA1, GCG
11thymoma27.4VIP, RAF1, CHGA, LBR, CD69, CD4
12monocytic leukemia27.2BMP6, PARP1, KAT5, MRC1, JUN, CD14
13melanoma27.2PIK3CG, PI3, PDE4A, RELA, KISS1R, VIP
14tuberculosis27.0IL10, IL12B, IL1B, IL4, CCL2, IFNG
15retinitis26.8PIK3CG, PDE4A, CNR1, CNR2, VIP, BOC
16tetanus26.3PIK3CG, VDAC1, BOC, PARP1, LBR, SAG
17obesity26.3PIK3CG, RELA, CNR1, CNR2, GCG, SELL
18fibrosis26.0PIK3CG, PI3, PDE4A, RELA, CNR1, CNR2
19cytomegalovirus infection25.8SELL, BMP6, CD40LG, CD38, ITGA4, ITGA5
20influenza25.7PIK3CG, RELA, SFTPA1, SELL, VDAC1, MYD88
21bronchiectasis25.5CFTR, CD79A, CD14, CD4, IL10, IL1B
22haemophilus influenzae25.4PIK3CG, VDAC1, LBP, CFH, ATP8A2, IL10
23atopy25.2RELA, CHRM3, CFTR, CD79A, CD14, IRAK1
24renal carcinoma24.7PIK3CG, BMP6, RAF1, BCL2L11, JUN, ITGB1
25astrocytoma24.5PIK3CG, RELA, CNR1, CNR2, LPAR1, LPAR2
26osteosarcoma24.4PIK3CG, PDE4A, RELA, CNR1, LPAR1, LPAR3
27myocardial infarction23.8PIK3CG, PI3, PDE4A, CNR1, CNR2, GCG
28cystic fibrosis23.7PIK3CG, PI3, PDE4A, SFTPA1, SELL, VIP
29ovarian cancer23.6PIK3CG, RELA, KISS1R, SERPING1, VIP, LPAR1
30breast carcinoma23.1PIK3CG, PI3, CNR2, KISS1R, LPAR1, LPAR2
31hepatitis16.0PIK3CG, RELA, CNR1, CNR2, KIAA0101, GCG
32fainting15.6BLZF1, FPR1, GNA11, GNA14, GNA15, GNAI1
33gonococcal synovitis15.1PIK3CG, PI3, PDE4A, RELA, CNR1, CNR2
34cadasil15.1CNR1, SELL, VIP, KCNJ5, KCNMA1, AVP
35congestive heart failure14.9PIK3CG, CHRM2, GUCA2A, GUCA2B, AOC3, MAPK10
36factor v leiden thrombophilia14.8SELL, CCL5, HTR3A, F2, F2R, CANT1
37mood disorder14.8PDE4A, CNR1, ARRB1, HTR1A, HTR1B, HTR2A
38hirschsprung's disease14.7GCG, VIP, CHGA, P2RY1, ITGB1, ITGB2
39lacrimal duct obstruction14.7PDE4A, SELL, SERPING1, UMOD, CCL11, NGF
40complement deficiency14.6CR1, C1S, C1R, C2, C4A, C4B
41breast cancer14.5PIK3CG, PDE4A, RELA, CNR1, CNR2, SELL
42drug dependence14.5CNR1, CHRM2, FOS, HTR3A, DRD1, DRD2
43arthritis14.5PIK3CG, PDE4A, RELA, CNR1, CNR2, SELL
44alcoholism14.5CNR1, CHRM2, LBR, CFTR, CCK, GPT
45drug addiction14.4MAPK1, DRD1, DRD2, DRD3, NTS, CREB1
46allergic asthma14.4PDE4A, SELL, CD69, CD14, ITGA4, ITGAL
47acute lymphoblastic leukemia14.3SELL, UMOD, JUN, CD247, CD38, ITGA4
48carcinoid syndrome14.3VIP, CHGA, IGF1, HTR3A, HTR7, CALCA
49prion disease14.3CNR1, BLZF1, HTR1A, HTR3A, HSPB1, HRH3
50cocaine dependence14.3CNR1, GRM2, DRD1, DRD2, DRD3, PDYN

Graphical network of the top 20 diseases related to pertussis:



Graphical network of diseases related to pertussis

Clinical Features for Pertussis

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Drugs & Therapeutics for Pertussis

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for pertussis

Drug clinical trials:

Search ClinicalTrials for pertussis

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Inferred drug relations via UMLS/NDF-RT:

43 28 demeclocycline, demeclocycline hydrochloride, erythromycin, erythromycin estolate, erythromycin ethylsuccinate, erythromycin gluceptate, erythromycin lactobionate, erythromycin pwdr [va product], erythromycin stearate, guaifenesin

Genetic Tests for Pertussis

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Anatomical Context for Pertussis

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11FMA, 22MalaCards
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MalaCards organs/tissues related to pertussis:

22
Lymph node, Brain, Heart, Smooth muscle, Small intestine, Adipocyte, Lung, Breast, Ovary, Monocytes, T cells, B cells, Endothelial, Bronchial epithelium, Pancreatic islet, Pituitary

FMA organs/tissues related to pertussis:

11
Respiratory tract

Phenotypes for genes affiliated with Pertussis

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25MGI
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MGI Mouse Phenotypes related to pertussis:

25 (show all 28)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1mortality/agingMP:001076815.0RELA, CNR1, KISS1R, GCG, NARFL, VDAC1
2homeostasis/metabolism phenotypeMP:000537614.5PIK3CG, RELA, CNR1, KISS1R, GCG, SELL
3hematopoietic system phenotypeMP:000539714.3KIAA0101, KISS1R, MYD88, RAC2, BCL2L11, SAC3D1
4behavior/neurological phenotypeMP:000538613.7CNR1, KISS1R, VIP, LPAR1, LPAR2, VDAC1
5growth/size phenotypeMP:000537813.6PIK3CG, RELA, CNR1, KISS1R, GCG, LPAR1
6nervous system phenotypeMP:000363113.1PDE4A, RELA, CNR1, KISS1R, LPAR2, VDAC1
7immune system phenotypeMP:000538713.1PDE4A, CNR2, KIAA0101, KISS1R, SELL, LPAR2
8respiratory system phenotypeMP:000538812.6SELL, LPAR2, BOC, CHRM2, CHRM1, CHRM3
9integument phenotypeMP:001077112.6PIK3CG, RELA, CNR1, CNR2, KISS1R, RAF1
10cellular phenotypeMP:000538412.3PIK3CG, RELA, CNR1, KIAA0101, SELL, MYD88
11normal phenotypeMP:000287312.2RELA, KISS1R, SERPING1, VIP, NARFL, LPAR2
12endocrine/exocrine gland phenotypeMP:000537912.0KISS1R, SELL, KCNJ6, CHRM3, CDC42, CD40LG
13renal/urinary system phenotypeMP:000536711.8KISS1R, MYD88, BCL2L11, KCNMA1, UMOD, CHRM2
14cardiovascular system phenotypeMP:000538511.5PIK3CG, PDE4A, RELA, SELL, SERPING1, LPAR1
15embryogenesis phenotypeMP:000538011.3LPAR3, RAF1, RAC1, PARP1, S1PR1, CFL1
16limbs/digits/tail phenotypeMP:000537111.3RELA, BOC, RAC1, BCL2L11, LEP, LBR
17digestive/alimentary phenotypeMP:000538111.2KISS1R, GCG, BOC, KCNMA1, LEP, CHRM1
18liver/biliary system phenotypeMP:000537011.1CHRM2, CHRM3, LBP, P2RY13, XCL1, CFTR
19craniofacial phenotypeMP:000538211.0LPAR1, BOC, LBR, CFTR, ITGA4, MITF
20no phenotypic analysisMP:000301210.5CNR1, MYD88, RAMP1, PARP1, LBR, CFL1
21adipose tissue phenotypeMP:000537510.4CNR1, LPAR1, MYD88, UMOD, LEP, CHRM3
22skeleton phenotypeMP:000539010.1PIK3CG, RELA, CNR1, MYD88, BMP6, RAF1
23reproductive system phenotypeMP:00053899.9KISS1R, VIP, KCNJ6, KCNMA1, LEP, S1PR2
24pigmentation phenotypeMP:00011869.9RAC1, BCL2L11, LEP, S1PR2, ITCH, ITGB1
25hearing/vestibular/ear phenotypeMP:00053779.6MYD88, PARP1, BCL2L11, KCNMA1, CHRM1, S1PR2
26muscle phenotypeMP:00053699.0PIK3CG, RELA, RAF1, RAMP1, RAC1, KCNJ6
27vision/eye phenotypeMP:00053918.9RELA, LPAR1, BOC, MYD88, RAF1, LEP
28tumorigenesisMP:00020068.6SELL, MYD88, LEP, S1PR2, KAT5, CD47

Publications for genes affiliated with Pertussis

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35PubMed
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Articles related to pertussis:

(show top 50)    (show all 267)
idTitleAuthorsYearAffiliating Genes
1Sphingosylphosphorylcholine inhibits melanin synthesi s via pertussis toxin-sensitive MITF degradation. (20487197)Kim D.S.... Park K.C.2010MITF
2Collagen-binding motif peptide, a cleavage product of osteopontin, stimulates human neutrophil chemotaxis via pertussis toxin-sensitive G protein-mediated signaling. (18804464)Kim M.K.... Bae Y.S.2008SPP1
3Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination. (18987746)Kimman T.G.... Kerkhof M.2008IRAK1, IRAK4, LBP
4Effect of lysophosphatidylglycerol on several signaling molecules in OVCAR-3 human ovarian cancer cells: involvement of pertussis toxin-sensitive G-protein coupled receptor. (17161826)Park K.S.... Bae Y.S.2007MAPK1
5Apolipoprotein CIII-induced THP-1 cell adhesion to endothelial cells involves pertussis toxin-sensitive G protein- and protein kinase C alpha-mediated nuclear factor-kappaB activation. (17038637)Kawakami A.... Sacks F.M.2007PRKCA, APOC3
6Specificity of Gbetagamma signaling to Kir3 channels depends on the helical domain of pertussis toxin-sensitive Galpha subunits. (17872944)Rusinova R.... Logothetis D.E.2007GNAQ
7Pertussis toxin B-oligomer suppresses IL-6 induced HIV-1 and chemokine expression in chronically infected U1 cells via inhibition of activator protein 1. (16393986)Rizzi C.... Alfano M.2006JUN
8Lysophosphatidic acid induces chemotaxis, oxygen radical production, CD11b up-regulation, Ca2+ mobilization, and actin reorganization in human eosinophils via pertussis toxin-sensitive G proteins. (15034064)Idzko M.... Norgauer J.2004LPAR1, LPAR3
9Role of nuclear factor-kappa B in the regulation of intercellular adhesion molecule 1 after infection of human bronchial epithelial cells by Bordetella pertussis. (12946329)Ishibashi Y.... Nishikawa A.2003ICAM1
10Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins. (12890892)Zhu Y.... Goto K.2003HCRTR2, HCRTR1, HCRT
11Role of phosphatidylinositol 3-kinase in the binding of Bordetella pertussis to human monocytes. (12464013)Ishibashi Y.... Relman D.A.2002PIK3CG, CD47
12Neurotoxic mechanisms triggered by Alzheimer's disease-linked mutant M146L presenilin 1: involvement of NO synthase via a novel pertussis toxin target. (11905990)Hashimoto Y.... Nishimoto I.2002PSEN1
13Pertussis toxin-induced reversible encephalopathy dependent on monocyte chemoattractant protein-1 overexpression in mice. (12486156)Huang D.... Ransohoff R.M.2002CCL2, IFNG, CXCR3
14Involvement of cyclic adenosine monophosphate-dependent protein kinase A and pertussis toxin-sensitive G proteins in the migratory response of human CD14+ mononuclear cells to katacalcin. (12369791)Kaneider N.C.... Wiedermann C.J.2002PRKACA, CALCA
15Melatonin mt1 and MT2 receptors stimulate c-Jun N-terminal kinase via pertussis toxin-sensitive and -insensitive G proteins. (11812653)Chan A.S.... Wong Y.H.2002CREB1
16Bordetella pertussis infection of human respiratory epithelial cells up-regulates intercellular adhesion molecule-1 expression: role of filamentous hemagglutinin and pertussis toxin. (12220988)Ishibashi Y.... Nishikawa A.2002ICAM1, ITGA5
17Role of pertussis toxin-sensitive G-proteins in intra cellular Ca2+ release and apoptosis induced by inhibiting cystic fibrosis trans membrane conductance regulator (CFTR) Cl- channels in HepG2 human hepatoblastom a cells. (11180400)Kim J.A.... Lee Y.S.2001CFTR, HSPG2
18The M3 muscarinic acetylcholine receptor expressed in HEK-293 cells signals to phospholipase D via G12 but not Gq-type G proteins: regulators of G proteins as tools to dissect pertussis toxin-resistant G proteins in receptor-effector coupling. (11036069)RA1menapp U.... Schmidt M.2001CHRM3
19Proinsulin C-peptide rapidly stimulates mitogen-activated protein kinases in Swiss 3T3 fibroblasts: requirement of protein kinase C, phosphoinositide 3-kinase and pertussis toxin-sensitive G-protein. (11256956)Kitamura T.... Saito M.2001PIK3CG, DYT10
20Down-regulation of IgE and IgG4 antibodies to tetanus toxoid and diphtheria toxoid by covaccination with cellular Bordetella pertussis vaccine. (11490032)GrA1ber C.... Aalberse R.C.2001IGHE
21Role of Bordetella pertussis virulence factors in adherence to epithelial cell lines derived from the human respiratory tract. (10024543)van den Berg B.M.... van Furth R.1999NARFL
22The novel sphingosine 1-phosphate receptor AGR16 is c oupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple si gnalling pathways. (9854026)Gonda K.... Takuwa Y.1999S1PR2
23Opioid potentiation of N-type Ca2+ channel currents via pertussis-toxin-sensitive G proteins in NG108-15 cells. (10398877)Morikawa H.... Fukuda K.1999OPRD1
24Pertussis toxin treatment in vivo reduces surface expression of the adhesion integrin leukocyte function antigen-1 (LFA-1). (10626903)Schenkel A.R.... Pauza C.D.1999ITGAL
25Role of antibodies against Bordetella pertussis virulence factors in adherence of Bordetella pertussis and Bordetella parapertussis to human bronchial epithelial cells. (10024542)van den Berg B.M.... van Furth R.1999NARFL
26The CGRP receptor can couple via pertussis toxin sensitive and insensitive G proteins. (9877154)Main M.J.... Foord S.M.1998CALCRL, RAMP1
27Pertussis toxin-insensitive signaling of the ORL1 receptor: coupling to Gz and G16 proteins. (9798948)Chan J.S.... Wong Y.H.1998DRD1, OPRL1, PNOC
28Pertussis toxin- and PMA-insensitive calcium mobilization by sphingosine in CFPAC-1 cells: evidence for a phosphatidic acid-dependent mechanism. (9296526)Orlati S.... Rugolo M.1997DGKQ, DYT10
29The monocyte chemotactic protein-4 induces oxygen radical production, actin reorganization, and CD11b up-regulation via a pertussis toxin-sensitive G-protein in human eosinophils. (9367876)Tenscher K.... Norgauer J.1997CCL11, CCL13
30Etorphine inhibits cell growth and induces apoptosis in SK-N-SH cells: involvement of pertussis toxin-sensitive G proteins. (9359460)Yin D.L.... Pei G.1997PNOC
31A somatostatin receptor inhibits noradrenaline release from chick sympathetic neurons through pertussis toxin-sensitive mechanisms: comparison with the action of alpha 2-adrenoceptors. (8783273)Boehm S.... Huck S.1996SST
32Recombinant human eotaxin induces oxygen radical production, Ca(2+)-mobilization, actin reorganization, and CD11b upregulation in human eosinophils via a pertussis toxin-sensitive heterotrimeric guanine nucleotide-binding protein. (8874220)Tenscher K.... Czech W.1996CCL11
33Co-stimulation of T cells via CD28 inhibits human IgE production; reversal by pertussis toxin. (7882571)Van der Pouw-Kraan C.T.... Aarden L.A.1995IGHE
34Inhibition of glycogen synthesis by epidermal growth factor in hepatocytes. The role of cell density and pertussis toxin-sensitive G TP-binding proteins. (8168540)Peak M.... Agius L.1994EGF, INS
35Adenosine 5'-triphosphate, phorbol ester, and pertussis toxin effects on atrial natriuretic peptide stimulation of guanylate cyclase in a human renal cell line. (7904711)Shigematsu Y.... Cole F.E.1994NPPA
36Immunoglobulin E and G responses to pertussis toxin after booster immunization in relation to atopy, local reactions and aluminium content of the vaccines. (8087191)Odelram H.... BjAPrkstAcn B.1994IGHE
37Effects of pertussis and cholera toxin on the interferon-gamma stimulated immunocytochemical staining of ICAM-1 and inositol phosphate formation in a human renal carcinoma cell line. (7908588)Hansen A.B.... Andersen C.B.1993ICAM1, IFNG
38Activation of phospholipase C by heat shock requires GTP analogs and is resistant to pertussis toxin. (8314854)Calderwood S.K.... Price B.D.1993HSPG2
39Molecular characterization of the in vitro activation of pertussis toxin by ATP. (8509398)Krueger K.M.... Barbieri J.T.1993PARP1
40Acute-phase proteins and levels of interleukin 1B, interleukin 6, tumor necrosis factor alpha, and interleukin 8 in children with pertussis. (7678186)Torre D.... Martegani R.1993TNF, IL6, IL8
41Pertussis toxin non-sensitive G protein mediates cholinergic stimulation for secretion of pancreastatin and somatostatin from QGP-1N cells. (1350105)Funakoshi A.... Kono A.1992GNAI1, SST, CHGA
42Involvement of pertussis toxin-sensitive G-proteins i n the hormonal inhibition of dihydropyridine-sensitive Ca2+ currents in an insu lin-secreting cell line (RINm5F). 18025-33 Adrenaline inhibits insulin secretion via pertuss is toxin-sensitive mechanisms. Since voltage-dependent Ca2+ currents play a key role in insulin secretion, we examined whether adrenaline modulates voltage-de pendent Ca2+ currents of the rat insulinoma cell line, RINm5F. In the whole-cel l configuration of the patch-clamp technique, dihydropyridine- but not omega-co notoxin-sensitive Ca2+ currents were identified. Adrenaline via alpha 2-adrenoc eptors inhibited the Ca2+ currents by about 50%. Somatostatin which also inhibi ts insulin secretion was less efficient (inhibition by 20%). The hormonal inhib ition of Ca2+ currents was not affected by intracellularly applied cAMP but blo cked by the intracellularly applied GDP analog guanosine 5'-O-(2-thiodiphosphat e) and by pretreatment of cells with pertussis toxin. In contrast to adrenaline and somatostatin, galanin, another inhibitor of insulin secretion, reduced Ca2 + currents by about 40% in a pertussis toxin-insensitive manner. Immunoblot exp eriments performed with antibodies generated against synthetic peptides reveale d that membranes of RINm5F cells possess four pertussis toxin-sensitive G-prote ins including Gi1, Gi2, Go2, and another Go subtype, most likely representing G o1. In membranes of control but not of pertussis toxin-treated cells, adrenalin e via alpha 2-adrenoceptors stimulated incorporation of the photo-reactive GTP analog [alpha-32P]GTP azidoanilide into pertussis toxin substrates comigrating with the alpha-subunits of Gi2, Go2, and the not further identified Go subtype. The present findings indicate that activated alpha 2-adrenoceptors of RINm5F c ells interact with multiple G-proteins, i.e. two forms of Go and with Gi2. Thes e G-proteins are likely to be involved in the adrenaline-induced inhibition of dihydropyridine-sensitive Ca2+ currents and in other signal transduction pathwa ys contributing to the adrenaline-induced inhibition of insulin secretion. Institut fA1r Pharmakologie, Freie UniversitAot Berlin, Federal Republic of Germany. Schmidt A A Hescheler J J Offermanns S S Spicher K K Hinsch K D KD Klinz F J FJ Codina J J Birnbaumer L L Gausepohl H H Frank R R eng Journal Article Research Support, Non-U.S. Gov't UNITED STATES J Biol Chem 2985121R 0021-9258 0 Dihydropyridines 0 Hormones 0 Virulence Factors, Bordetella 11061-68-0 Insulin 3337-17-5 1,4-dihydropyridine 4205-90-7 Clonidine 51-43-4 Epinephrine 51110-01-1 Somatostatin 7440-70-2 Calcium EC 2.4.2.31 Pertussis Toxin EC 3.6.1.- GTP-Binding Proteins IM Animals Calcium metabolism Clonidine pharmacology Dihydropyridines pharmacology Electrophoresis, Polyacrylamid e Gel Epinephrine physiology GTP-Binding Proteins metabolism Hormones physiology Insulin secretion Insulinoma pathology secretion Membrane Potentials Pertussis Toxin Rats Somatostatin physiology Tumor Cells, Cultured secretion Virulence Factors, Bordetella pharmacology 1991 9 25 1991 9 25 0 1 1991 9 25 0 0 ppublish 1680855 1680855 1991 10 29 1991 10 29 2006 11 15
0021-9258 266 27 1991 Sep 25 The Journal of biological chemistry J. Biol. Chem. Involvement of pertussis toxin-sensitive G-proteins i n the hormonal inhibition of dihydropyridine-sensitive Ca2+ currents in an insu lin-secreting cell line (RINm5F). (4)
Schmidt A.... Frank R.1991KLK5
43Effects of pertussis toxin, dibutyryl-cyclic-AMP, bro mo-cyclic-AMP and forskolin on the behavioural and electrocortical power spectr um changes induced by microinfusion of interleukin-2 into the locus coeruleus. (1663494)De Sarro G.... NisticA^ G.1991IL2, ADCY10
44The epidermal growth factor receptor is coupled to a pertussis toxin-sensitive guanine nucleotide regulatory protein in rat hepatocytes. (1649188)Liang M.N.... Garrison J.C.1991EGF
45Agonist-dependent, cholera toxin-catalyzed ADP-ribosylation of pertussis toxin-sensitive G-proteins following transfection of the human alpha 2-C10 adrenergic receptor into rat 1 fibroblasts. Evidence for the direct interaction of a single receptor with two pertussis toxin-sensitive G-proteins, Gi2 and Gi3. (1848855)Milligan G.... Lavan B.E.1991ADRA2A
46Mastoparan, a novel mitogen for Swiss 3T3 cells, stimulates pertussis toxin-sensitive arachidonic acid release without inositol phosphate accumulation. (1709171)Gil J.... Rozengurt E.1991EGFR, GRP
47Regulation of bradykinin receptor level by cholera toxin, pertussis toxin and forskolin in cultured human fibroblasts. (1653071)Etscheid B.G.... Villereal M.L.1991KNG1
48Pertussis toxin B-subunit-induced Ca2(+)-fluxes in Jurkat human lymphoma cells: the action of long-term pre-treatment with cholera and pertussis holotoxins. (2169284)Sommermeyer H.... Resch K.1990PARP1, ADCY10
49Pertussis toxin inhibits EGF-, phorbol ester- and insulin-stimulated DNA synthesis in BALB/c3T3 cells: evidence for post-receptor activation of Gi alpha. (2108675)Crouch M.F.... Hendry I.A.1990GNAI1
50Identification of a GTP-binding protein alpha subunit that lacks an apparent ADP-ribosylation site for pertussis toxin. (3129724)Fong H.K.W.... Simon M.I.1988GNAZ

Expression for genes affiliated with Pertussis

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Pertussis

Pathways for genes affiliated with Pertussis

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36QIAGEN, 41Thomson Reuters, 10EMD Millipore, 38Reactome, 20KEGG
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Pathways related to pertussis according to GeneDecks:

(show top 50)    (show all 453)
idPathwayScoreTop Affiliating Genes
1RAR-Gamma-RXR-Alpha Degradation3612.1IL12A, IL2, IL23A, MAPK12, MAPK13, MAPK14
2Immune response_Classical complement pathway4111.9SERPING1, ITGAM, ITGB2, CR1, C1QA, C1S
3Sperm Motility3611.9PDE4A, GUCY2C, GPLD1, GNA11, GNA14, GNA15
4G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins1011.8PIK3CG, RAC1, CDC42, MAPK8, MAPK12, MAPK13
5Development_Endothelin-1/EDNRA signaling4111.7RAC1, CDC42, MAPK14, MAPK10, GNA11, GNAI1
6G-Beta Gamma Signaling3611.5RAF1, KCNJ6, KCNJ9, KCNJ3, KCNJ5, CDC42
7G alpha (q) signalling events3811.4KISS1R, XCL1, GRP, CCK, GNRH1, GNRHR
8Toll Comparative Pathway3611.3MYD88, CD14, IRAK1, IRAK3, IRAK4, MAPK8
9Development EDNRB signaling1011.3PIK3CG, RAF1, FOS, MAPK3, MAP2K1, GNA11
10CXCR4 Pathway3611.3RAF1, RAC1, RAC2, JUN, CDC42, FOS
11Signal transduction_IP3 signaling4111.3RAF1, P2RY1, P2RY2, P2RY4, CD79A, CD247
12Signal transduction IP3 signaling1011.2RAF1, P2RY1, P2RY2, P2RY4, CD79A, CD247
13PKA Signaling3611.2RAF1, MAPK1, MAP2K1, GNA11, GNA14, GNA15
14Immune response_Fc epsilon RI pathway4111.2RELA, RAF1, RAC1, MAPK12, MAPK13, MAPK3
15Transcription CREB pathway1011.2RAF1, RAC1, MAPK12, MAPK13, MAPK3, MAPK14
16Development ACM2 and ACM4 activation of ERK1011.1PIK3CG, RAF1, CHRM2, FOS, MAPK3, MAPK1
17Development Angiotensin signaling via PYK21011.1RAF1, RAC1, JUN, FOS, MAPK8, MAPK3
18Immune response_IFN gamma signaling pathway4111.0IRF1, MAPK12, MAPK13, MAPK3, MAPK14, MAPK11
19Pancreatic cancer2011.0RAC2, IKBKG
20G-AlphaQ Signaling3611.0RAF1, MAPK3, MAPK1, MAP2K1, GPLD1, IKBKG
21NGF Pathway3610.9RAF1, RAC1, RAC2, CDC42, MAPK8, MAPK3
22TLR-TRIF Pathway3610.9MYD88, IRAK1, IRAK3, IRAK4, IRF3, MAPK8
23S-1P Stimulated Signaling3610.8RAC1, RAC2, MAPK12, MAPK3, MAPK1, GNAI1
24CREB Pathway3610.8BMP6, FGFR2, GRIK1, GRM1, GRM2, GRM3
25ERK5 Signaling3610.7BMP6, FOS, IL2, IL6, IGF2, GNA11
26Development_FGFR signaling pathway4110.6RAF1, RAC1, JUN, FGF2, MAPK8, MAPK12
27Long-term potentiation2010.6RAF1, GRM1, MAPK3, MAPK1, MAP2K1, GNAQ
28Glioma2010.6PIK3CG, RAF1, MAPK3, MAPK1, MAP2K1, IGF1R
29IP3 Pathway3610.5BMP6, CD79A, FGF2, FGFR2, IL2, IGF2
30Development_FGF-family signaling4110.5RAF1, RAC1, FGF2, FGFR2, MAPK12, MAPK13
3114-3-3 Induced Apoptosis3610.4MYD88, JUN, FOS, IRAK1, IRAK3, IRAK4
32Development Prolactin receptor signaling1010.3RELA, RAF1, RAC1, JUN, IRF1, MAPK3
33Long-term depression2010.3RAF1, GRM1, MAPK3, MAPK1, MAP2K1, IGF1R
34Development_EGFR signaling pathway4110.3RAF1, RAC1, JUN, FOS, MAPK8, MAPK3
35Fc epsilon RI signaling pathway2010.3PIK3CG, RAC1, RAC2, IL4, MAP2K1, HRAS
36UVA-Induced MAPK Signaling3610.2JUN, FOS, MAPK8, MAPK12, MAPK13, MAPK14
37P2Y Receptor Signaling3610.1RAF1, P2RY1, P2RY2, P2RY4, JUN, FOS
38MAPK Signaling3610.1BMP6, RAF1, RAC1, JUN, CDC42, ITGA4
39PEDF Induced Signaling3610.0RELA, BMP6, RAF1, FOS, IL10, IL12A
40Signaling in Gap Junctions369.8RAF1, GUCY2C, GRM1, GRM2, GRM3, GRM7
41JNK Pathway369.8BMP6, RAF1, RAC1, JUN, CDC42, CD4
42Activation of PKA through GPCR369.7GCG, BMP6, RAF1, FGF2, FGFR2, IL2
43T cell receptor signaling pathway209.7PIK3CG, RELA, RAF1, JUN, CDC42, CD4
44Immune response IL-1 signaling pathway109.7RELA, MYD88, JUN, FOS, IRAK1, IRAK4
45Cytokine-cytokine receptor interaction209.6LEP, XCL1, CD40LG, IL10, IL12A, IL12B
46Malaria209.5MYD88, CD40LG, ITGAL, ITGB2, IL10, IL12A
47Intracellular Calcium Signaling369.5BMP6, GUCY2C, FGF2, FGFR2, GRIK1, IL2
48Rap1 Pathway369.3BMP6, RAF1, ITGA4, ITGA5, ITGAL, ITGAM
49Renin-Angiotensin Pathway369.2BMP6, RAF1, RAC1, JUN, FOS, FGF2
50PAK Pathway369.2BMP6, RAC1, RAC2, CFL1, CFL2, CDC42

Compounds for genes affiliated with Pertussis

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Sources:
32Novoseek , 18HMDB, 9DrugBank, 42Tocris Bioscience, 34PharmGKB
See all sources

Compounds related to pertussis according to GeneDecks:

(show top 50)    (show all 443)
idCompoundScoreTop Affiliating Genes
1lipid32 15.1PIK3CG, PI3, PDE4A, CNR1, CNR2, GCG
2cyclic amp32 18 14.4PDE4A, CNR1, CNR2, GCG, LPAR3, KCNMA1
3phospholipid32 12.8PDE4A, LPAR1, LPAR2, LPAR3, VDAC1, BLZF1
4potassium32 9 18 9 15.0PDE4A, VIP, VDAC1, RAMP1, BLZF1, BCL2L11
5endotoxin32 12.0SELL, MYD88, LBP, SAA1, CD14, ITGAL
6h2o232 11.8PIK3CG, PDE4A, SELL, VIP, VDAC1, BLZF1
7threonine32 11.7LPAR3, RAF1, CHRM2, CHRM3, AVP, CDC42
8forskolin32 42 9 9 14.7PDE4A, CNR2, GCG, VIP, BMP6, RAF1
9pge232 11.7PDE4A, VIP, RAF1, RAC1, KCNMA1, SAG
10fmlp32 11.6PIK3CG, PDE4A, SELL, RAC1, RAC2, SCG2
11inositol32 11.6PDE4A, CHGA, CHRM3, LBR, P2RY2, CD79A
12okadaic acid32 42 12.6RELA, BMP6, RAF1, BLZF1, KCNMA1, LBR
13wortmannin32 42 12.5PIK3CG, PI3, PDE4A, GCG, RAF1, RAC1
14haloperidol32 34 9 9 14.4VIP, RABEP2, KCNJ5, CHGA, FOS, MC4R
15estrogen32 11.2GCG, VIP, RABEP2, RAF1, KCNJ5, KCNMA1
16phorbol32 11.1SELL, RAF1, RAC1, RAC2, CHGA, JUN
17cocaine32 9 9 13.1PDE4A, CNR1, GCG, BMP6, RABEP2, LEP
18rituximab32 34 9 9 14.0RAF1, CD79A, CD40LG, CD38, FCGR3B, IL10
19latex32 10.9VDAC1, BLZF1, CD14, CDC42, ITGAL, ITGAM
20ccl432 10.9XCL1, IL12B, CCL4, CCL15, CCL22, CCL2
21chelerythrine32 10.8PIK3CG, KCNJ5, FOS, MAPK8, MAPK14, MAPK10
22glibenclamide32 34 11.7CNR1, GCG, VIP, KCNJ5, KCNMA1, LEP
23thapsigargin32 42 11.7PIK3CG, CNR1, VIP, LPAR3, RAF1, BLZF1
24staurosporin32 10.7PIK3CG, JUN, ITGAL, IL8, MAPK14, MAPK10
25pirenzepine32 9 9 12.5GCG, CHRM2, CHRM1, CHRM3, GRP, CCK
26egcg32 10.5PIK3CG, RAF1, IL1A, MAPK8, MAPK3, MAPK14
27etoposide32 42 9 9 13.4PIK3CG, PARP1, BCL2L11, LGALS1, CHGA, JUN
28vegf32 10.4PIK3CG, PDE4A, GCG, VIP, LPAR1, LPAR2
29methacholine32 9 9 12.3VIP, KCNJ5, KCNMA1, CHRM3, CD79A, CD14
30nifedipine32 9 9 12.3PIK3CG, GCG, VIP, BMP6, KCNJ5, KCNMA1
31verapamil32 34 9 18 9 14.3VIP, CFTR, FGF2, MAPK10, GPT, GNRH1
32octreotide32 42 9 9 13.3GCG, VIP, CHGA, INS, GRP, CCK
335-hydroxytryptamine32 10.2CNR1, GCG, VIP, BMP6, RAF1, SCG2
34hyaluronic acid32 18 11.1MYOM2, BMP6, RAC1, CFH, ITGAL, ITGB2
35clozapine32 34 9 9 12.9KCNJ6, KCNJ3, LEP, CHRM2, CHRM1, CHRM3
36glycerol32 9 18 9 12.9PDE4A, GCG, LPAR1, VDAC1, LEP, CFTR
37glutamine32 9.8PIK3CG, PDE4A, GCG, VIP, VDAC1, BMP6
38ndga32 9.7JUN, FPR1, FOS, IL1B, MAPK10, IGF1R
39imatinib32 34 9 9 12.7PIK3CG, SELL, VIP, BMP6, RAF1, PARP1
40resveratrol32 9 18 9 12.7PIK3CG, RAF1, PARP1, JUN, CD14, GUSB
41polyinosinic-polycytidylic acid32 9.4IRF1, IRF3, IL10, IL12B, IL2, IL4
42paclitaxel32 34 9 9 12.3PIK3CG, BMP6, RAF1, RAC1, PARP1, BCL2L11
43quercetin32 42 9 18 9 13.3PIK3CG, RAF1, PARP1, CFTR, JUN, GUSB
44genistein32 9 18 9 12.2PIK3CG, GCG, SELL, RAF1, RAC1, BLZF1
45retinoic acid32 42 18 11.2PIK3CG, PI3, PDE4A, SELL, BMP6, RAF1
46polymyxin b32 9.1VDAC1, LBP, CD14, ITGB2, IL10, IL1A
47butyrate32 9.1GCG, BMP6, RAF1, BLZF1, LGALS1, LEP
48pentoxifylline32 9 9 10.9PDE4A, SELL, BMP6, LBR, CD14, ITGA4
49vitamin d32 8.8BMP6, CHGA, LBR, CFTR, JUN, CD79A
50pdtc32 8.0PIK3CG, RAF1, PARP1, JUN, FOS, IRF1

GO Terms for genes affiliated with Pertussis

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Sources:
12Gene Ontology
See all sources

Cellular components related to pertussis according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588617.3GRM3, ICAM1, HTR1A, HTR1B, HTR2A, HTR3A
2integral to plasma membraneGO:00588713.8ART1, HTR2A, HTR3A, HTR7, F2R, GNRHR
3cytosolGO:00582912.1PLCG1, PLCB1, PLCB3, NOD1, NOS2, RPS27A
4endosome membraneGO:01000811.4SHC1, EGFR, TYRP1, TLR4, TICAM1, TICAM2
5extracellular regionGO:00557610.8LTF, THBS1, TGFB1, TF, TAC1, DEFB1
6secretory granuleGO:03014110.3LTF, HCRT, THBS1, TF, OXT, POMC
7external side of plasma membraneGO:00989710.3CCR1, IFNG, ICAM1, TNF, TNFRSF14, TNFRSF18
8cell surfaceGO:00998610.0CCR5, HSPB1, TNF, TNFRSF4, TNFSF4, CR1
9axonGO:0304249.9DRD1, DRD2, TGFB1, TAC1, NPY1R, ADRBK1
10extracellular spaceGO:0056158.9PYY, TGFB1, DPT, TAC1, OXT, CXCL10

Biological processes related to pertussis according to GeneDecks:

(show top 50)    (show all 97)
idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor signaling pathwayGO:00718613.2PIK3CG, KISS1R, GCG, VIP, LPAR1, LPAR2
2innate immune responseGO:04508713.1PIK3CG, RELA, SERPING1, MYD88, LBP, CFH
3signal transductionGO:00716512.8PDE4A, GCG, MYD88, RAF1, RAC2, LGALS1
4G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718712.6CNR1, CNR2, LPAR3, CHRM2, MTNR1A, MTNR1B
5inflammatory responseGO:00695412.3PIK3CG, RELA, CNR2, MYD88, BMP6, RAC1
6immune responseGO:00695512.1CNR2, BMP6, S1PR4, P2RY14, XCL1, CD4
7elevation of cytosolic calcium ion concentrationGO:00720412.1LPAR1, LPAR2, LPAR3, SAA1, S1PR3, S1PR4
8cell-cell signalingGO:00726712.0XCL1, AVP, ITGB2, INS, FGFR2, IL10
9Toll signaling pathwayGO:00806311.8RELA, MYD88, LBP, JUN, CD14, FOS
10toll-like receptor 4 signaling pathwayGO:03414211.7RELA, MYD88, JUN, CD14, FOS, IRAK1
11MyD88-dependent toll-like receptor signaling pathwayGO:00275511.6RELA, MYD88, JUN, FOS, IRAK1, IRAK3
12toll-like receptor signaling pathwayGO:00222411.5RELA, MYD88, JUN, FOS, IRAK1, IRAK4
13adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:00719311.5S1PR1, S1PR3, P2RY1, GNAI1, GNAI2, GNAI3
14blood coagulationGO:00759611.5PIK3CG, SELL, SERPING1, RAF1, RAC1, RAC2
15response to lipopolysaccharideGO:03249611.5CNR1, CNR2, LBP, JUN, IRAK1, IRAK3
16toll-like receptor 3 signaling pathwayGO:03413811.4RELA, JUN, CD14, FOS, IRAK1, IRF3
17TRIF-dependent toll-like receptor signaling pathwayGO:03566611.4RELA, JUN, CD14, FOS, IRAK1, IRF3
18toll-like receptor 1 signaling pathwayGO:03413011.4RELA, MYD88, JUN, FOS, IRAK1, IRAK4
19toll-like receptor 2 signaling pathwayGO:03413411.4RELA, MYD88, JUN, FOS, IRAK1, IRAK4
20positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312311.3RELA, LPAR1, MYD88, LGALS1, IRAK1, IRF3
21MyD88-independent toll-like receptor signaling pathwayGO:00275611.3RELA, JUN, FOS, IRAK1, IRF3, MAPK8
22activation of phospholipase C activityGO:00720211.2LPAR1, LPAR2, S1PR4, GNA15, GNAQ, CALM3
23synaptic transmissionGO:00726811.1LPAR3, RAF1, KCNJ6, KCNJ9, KCNJ3, KCNJ5
24positive regulation of tumor necrosis factor productionGO:03276011.1MYD88, LBP, CD14, IL12B, IL23A, CCL3
25cellular component movementGO:00692810.9RAC1, SCG2, ITGAL, FPR1, FPR2, IL8
26cell surface receptor signaling pathwayGO:00716610.8MYD88, SAG, P2RY1, CD14, CD4, MAPK14
27negative regulation of adenylate cyclase activityGO:00719410.8GRM2, GRM3, GRM7, CCR2, GNAI2, GNAI3
28activation of MAPK activityGO:00018710.7LPAR1, LPAR2, LPAR3, S1PR2, FPR1, IRAK1
29stress-activated MAPK cascadeGO:05140310.7JUN, FOS, IRAK1, MAPK8, MAPK3, MAPK14
30agingGO:00756810.7CNR1, P2RY1, P2RY2, JUN, IL1B, CCL2
31activation of MAPKK activityGO:00018610.7KISS1R, RAF1, GRM1, F2R, GNAI2, PLCG1
32cellular calcium ion homeostasisGO:00687410.7ITGB1, CCL15, CCR2, CCL2, CCL11, CCR1
33neutrophil chemotaxisGO:03059310.7PIK3CG, SAA1, XCL1, ITGB2, IL1B, IL8
34chemotaxisGO:00693510.6FPR1, FPR2, FGF2, IL4, ENPP2, MAPK14
35cytokine-mediated signaling pathwayGO:01922110.6RELA, MYD88, IRAK3, IRAK4, IRF1, IRF3
36nerve growth factor receptor signaling pathwayGO:04801110.6RELA, MYD88, RAF1, RAC1, BCL2L11, IRAK1
37platelet activationGO:03016810.5PIK3CG, SERPING1, RAF1, RAC1, RAC2, SAA1
38lipopolysaccharide-mediated signaling pathwayGO:03166310.3MYD88, LBP, IRAK1, IRF3, IL1B, MAPK3
39positive regulation of NF-kappaB transcription factor activityGO:05109210.1RELA, MYD88, IRAK1, IRAK3, INS, IL1B
40positive regulation of ERK1 and ERK2 cascadeGO:07037410.0GCG, P2RY1, ARRB1, FGF2, FGFR2, IL1A
41epidermal growth factor receptor signaling pathwayGO:0071739.9RAF1, CDC42, MAPK3, MAPK1, MAP2K1, CALM3
42MAPK cascadeGO:0001659.6RAF1, SCG2, INS, IL1B, MAPK12, MAPK13
43negative regulation of cell proliferationGO:0082859.5KISS1R, RAF1, UMOD, ATP8A2, JUN, ITGB1
44response to hypoxiaGO:0016669.4NARFL, RAF1, KCNMA1, LEP, IL1A, IL1B
45apoptotic processGO:0069159.4VDAC1, RAF1, RAC1, BCL2L11, LGALS1, CD14
46positive regulation of smooth muscle cell proliferationGO:0486619.3MYD88, S1PR1, JUN, IRAK4, IL6, CCL5
47positive regulation of cell proliferationGO:0082849.2VIP, RAC2, LEP, CHRM1, S1PR2, S1PR3
48positive regulation of nitric oxide biosynthetic processGO:0454299.2INS, IL1B, IFNG, ICAM1, HRH1, AKT1
49response to drugGO:0424939.1PDE4A, LGALS1, JUN, CD38, ITGB1, IL10
50negative regulation of apoptotic processGO:0430668.3PIK3CG, RELA, GCG, RAF1, SCG2, LEP

Molecular functions related to pertussis according to GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551513.2CXCR4, TH, TIRAP, TIMP1, TICAM1, TLR4
2chemokine activityGO:00800911.6C5, CCL4, IL8, XCL1, CCL15, CCL22
3neuropeptide hormone activityGO:00518411.3PNOC, HCRT, NPY, ADCYAP1, GAL, NTS
4receptor bindingGO:00510210.9CXCL12, CXCL10, EDN3, NOS2, PLA2G1B, POMC
5phosphatidylinositol phospholipase C activityGO:00443510.1PLCB4, PLCG1, PLCB1, PLCB3, EDNRA, PLCB2
6drug bindingGO:0081449.9ALB, DRD1, DRD2, DRD3, ADRB2, HTR2A
7hormone activityGO:0051799.4GAST, ADM, NPPA, POMC, PRL, EDN3
8cytokine activityGO:0051258.3IL6, CCL4, IFNG, TNF, TNFSF4, SPP1
9growth factor activityGO:0080838.0IGF1, F2, GH1, NGF, EGF, TGFB1

Sources for Pertussis

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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