Aliases & Classifications for Pertussis

MalaCards integrated aliases for Pertussis:

Name: Pertussis 12 50 56 3 3 14 69
Whooping Cough 12 50 56 41 3 42
Bordetella Infections 42 69
Whooping Cough Due to Unspecified Organism 69
Bordetella Pertussis Infection 50
Bordetella Infection 12
Wc - Whooping Cough 12

Characteristics:

Orphanet epidemiological data:

56
whooping cough
Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:1116
SNOMED-CT 64 26484003
Orphanet 56 ORPHA1489
MESH via Orphanet 43 D014917
UMLS via Orphanet 70 C0043167 C0043168
ICD10 via Orphanet 34 A37.0 A37.1 A37.8 more
UMLS 69 C0006015

Summaries for Pertussis

MedlinePlus : 41 whooping cough is an infectious bacterial disease that causes uncontrollable coughing. the name comes from the noise you make when you take a breath after you cough. you may have choking spells or may cough so hard that you vomit. anyone can get whooping cough, but it is more common in infants and children. it's especially dangerous for infants. the coughing spells can be so bad that it is hard for infants to eat, drink, or breathe. to make a diagnosis, your doctor may do a physical exam, blood tests, chest x-rays, or nose or throat cultures. before there was a vaccine, whooping cough was one of the most common childhood diseases and a major cause of childhood deaths in the u.s. now most cases are prevented by vaccines. if you have whooping cough, treatment with antibiotics may help if given early. centers for disease control and prevention

MalaCards based summary : Pertussis, also known as whooping cough, is related to legionellosis and lymphoma, and has symptoms including coughing, fever and pruritus. An important gene associated with Pertussis is GNA14 (G Protein Subunit Alpha 14), and among its related pathways/superpathways are Pertussis and Innate Immune System. The drugs Montelukast and Edetic Acid have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and monocytes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 A commensal bacterial infectious disease that results_in inflammation located in respiratory tract, has material basis in Bordetella pertussis, or has material basis in Bordetella parapertussis, which produce toxins that paralyze the cilia of the respiratory epithelial cells. The infection is characterized by a prolonged, high-pitched, deeply indrawn breath (whoop).

Wikipedia : 72 Pertussis (also known as whooping cough or 100-day cough) is a highly contagious bacterial disease.... more...

Related Diseases for Pertussis

Diseases related to Pertussis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 264)
id Related Disease Score Top Affiliating Genes
1 legionellosis 30.0 IL1B IL6 TNF
2 lymphoma 29.6 IL10 IL1B IL6 TNF
3 inner ear disease 29.5 IL10 IL6 TLR4 TNF
4 carotid artery dissection 29.3 IL10 IL1B IL6 TNF
5 myocardial infarction 28.5 IL10 IL1B IL6 ITGAM TLR4 TNF
6 diphtheria 11.4
7 bordetella parapertussis whooping cough 10.8
8 ethmoid sinus cancer 10.7 IL1B JUN TLR4
9 pure autonomic failure 10.7 IL10 TNF
10 tetanus 10.7
11 acute ackee fruit intoxication 10.7 IL10 TNF
12 prothrombin thrombophilia 10.6 IL1B TLR4
13 isolated growth hormone deficiency 10.6 IL1B JUN TLR4
14 testicular infarct 10.6 IL1B TLR4 TNF
15 classic phenylketonuria 10.6 GNA11 GNAQ
16 subglottis neoplasm 10.6 IL1B IL6 TLR4
17 smarca4-deficient sarcoma of thorax 10.6 IL6 TNF
18 syphilitic encephalitis 10.6 IL1B IL6 TLR4
19 trichosporonosis 10.5 ITGAM TLR4 TNF
20 polyneuropathy in collagen vascular disease 10.5 FOS IL6 JUN
21 antigen-peptide-transporter 2 deficiency 10.5 IL6 TLR4 TNF
22 senile reticular retinal degeneration 10.5 IL10 IL1B TNF
23 infancy electroclinical syndrome 10.5 IL10 IL1B IL6
24 tabatznik syndrome 10.5 IL1B TNF
25 gastroduodenal crohn's disease 10.5 IL6 TLR4 TNF
26 cicatricial lagophthalmos 10.5 IL6 MAPK1 TNF
27 oculomotor nerve paralysis 10.5 IL1B IL6
28 dengue disease 10.4 IL10 TLR4 TNF
29 extrahepatic bile duct papillary adenoma 10.4 IL10 IL1B TNF
30 scrotal carcinoma 10.4 IL1B IL6 TNF
31 bipolar i disorder 10.4 IL1B IL6 TNF
32 tinea favosa 10.4 IL1B IL6 TNF
33 mucocutaneous leishmaniasis 10.4 IL10 TLR4 TNF
34 central nervous system leiomyosarcoma 10.4 IL1B IL6 TNF
35 indolent myeloma 10.4 IL1B IL6 TNF
36 stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features 10.4 IL1B IL6 TNF
37 ethmoid sinus adenocarcinoma 10.4 IL10 IL6 TNF
38 acquired thrombocytopenia 10.4 IL1B IL6 TNF
39 ampulla of vater neoplasm 10.4 IL1B IL6 TNF
40 benign neonatal seizures 10.4 IL1B IL6 TNF
41 megaloblastic anemia 10.4 IL10 IL1B TLR4 TNF
42 pyelonephritis 10.4 IL10 IL1B TNF
43 bartonellosis 10.4 IL10 IL1B TLR4 TNF
44 keloids 10.4 IL1B IL6 TNF
45 influenza 10.4
46 tricho onychic dysplasia 10.4 IL10 IL6 TNF
47 brucella canis brucellosis 10.4 IL1B IL6 TNF
48 phlyctenulosis 10.4 IL10 IL6 TNF
49 foodborne botulism 10.4 IL1B IL6 TNF
50 churg-strauss syndrome 10.4 IL10 IL1B TNF

Graphical network of the top 20 diseases related to Pertussis:



Diseases related to Pertussis

Symptoms & Phenotypes for Pertussis

UMLS symptoms related to Pertussis:


coughing, fever, pruritus, snoring

MGI Mouse Phenotypes related to Pertussis:

44 (show all 18)
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.45 FOS GNA11 GNAI1 GNAQ GNAZ IL10
2 homeostasis/metabolism MP:0005376 10.44 TLR4 TNF JUN MAPK1 MAPK10 OPRM1
3 behavior/neurological MP:0005386 10.39 FOS GNA11 GNAI1 GNAQ GNAZ IL10
4 immune system MP:0005387 10.37 FOS GNA11 GNAI1 GNAQ IL10 IL1B
5 cardiovascular system MP:0005385 10.35 GNA11 GNAQ IL10 IL1B IL6 ITGB2
6 cellular MP:0005384 10.34 OPRM1 TICAM1 TLR4 TNF FOS IL10
7 growth/size/body region MP:0005378 10.31 FOS GNA11 GNAQ GNAZ IL10 IL6
8 integument MP:0010771 10.29 FOS GNA11 GNAQ GNAZ IL10 IL1B
9 mortality/aging MP:0010768 10.25 GNAZ IL10 IL1B IL6 ITGB2 JUN
10 nervous system MP:0003631 10.22 GNAZ IL10 IL1B IL6 ITGAM JUN
11 endocrine/exocrine gland MP:0005379 10.2 FOS GNA11 GNAQ IL10 IL6 JUN
12 liver/biliary system MP:0005370 10.03 GNA11 IL10 IL6 JUN MAPK1 TICAM1
13 limbs/digits/tail MP:0005371 10 FOS GNA11 GNAQ IL10 TICAM1 TLR4
14 neoplasm MP:0002006 9.97 FOS IL10 IL1B IL6 MAPK1 TICAM1
15 normal MP:0002873 9.91 TLR4 FOS GNA11 GNA15 GNAQ IL10
16 respiratory system MP:0005388 9.76 IL10 IL6 JUN MAPK1 TLR4 TNF
17 skeleton MP:0005390 9.73 FOS GNA11 GNAI1 GNAQ IL10 IL1B
18 vision/eye MP:0005391 9.28 FOS IL10 IL6 ITGB2 JUN MAPK1

Drugs & Therapeutics for Pertussis

Drugs for Pertussis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 122)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Montelukast Approved Phase 4 158966-92-8 5281040
2
Edetic Acid Approved, Vet_approved Phase 4,Phase 3,Phase 2 60-00-4, 62-33-9 6049
3
Iron Approved Phase 4,Phase 3,Phase 2 7439-89-6 23925
4
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
5
Ibuprofen Approved Phase 4 15687-27-1 3672
6
BCG vaccine Investigational Phase 4,Phase 2
7 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
8 Anti-Asthmatic Agents Phase 4
9 Hormone Antagonists Phase 4,Phase 3
10 Hormones Phase 4,Phase 3
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
12 Leukotriene Antagonists Phase 4
13 Respiratory System Agents Phase 4
14 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
15 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
16 Adjuvants, Immunologic Phase 4,Phase 3,Phase 1,Phase 2
17 Heptavalent Pneumococcal Conjugate Vaccine Phase 4,Phase 3,Phase 2,Phase 1
18 Protective Agents Phase 4,Phase 3,Phase 2
19 Aluminum phosphate Phase 4,Phase 3,Phase 1,Phase 2
20 Antacids Phase 4,Phase 3,Phase 2
21 Anti-Ulcer Agents Phase 4,Phase 3,Phase 2
22 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
23 Antidotes Phase 4,Phase 3,Phase 2
24 Antitoxins Phase 4,Phase 3
25 Diphtheria Antitoxin Phase 4,Phase 3
26 Tetanus Antitoxin Phase 4,Phase 3
27 Anticoagulants Phase 4,Phase 3,Phase 2
28 Calcium, Dietary Phase 4,Phase 3,Phase 2
29 Chelating Agents Phase 4,Phase 3,Phase 2
30 Iron Chelating Agents Phase 4,Phase 3,Phase 2
31 Pentetic Acid Phase 4,Phase 3,Phase 2
32 Fibrinolytic Agents Phase 4,Phase 3,Phase 2
33 PENTA Phase 4,Phase 3,Phase 2
34 Analgesics Phase 4,Phase 3,Phase 1
35 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 1
36 Anti-Inflammatory Agents Phase 4,Phase 3
37 Anti-Inflammatory Agents, Non-Steroidal Phase 4
38 Antipyretics Phase 4,Phase 3
39 Antirheumatic Agents Phase 4
40 Cyclooxygenase Inhibitors Phase 4
41 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1
42
Deferiprone Approved Phase 3 30652-11-0 2972
43
Aluminum hydroxide Approved Phase 3,Phase 2 21645-51-2
44
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
45
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
46
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
47
Lactitol Investigational Phase 3,Phase 2 585-86-4 3871
48 gamma-Globulins Phase 3
49 Immunoglobulins, Intravenous Phase 3
50 Rho(D) Immune Globulin Phase 3

Interventional clinical trials:

(show top 50) (show all 453)

id Name Status NCT ID Phase Drugs
1 Diphtheria, Tetanus, Poliomyelitis -Pertussis-Hib Immunisation in Preterm-born Neonates Unknown status NCT02179996 Phase 4
2 The Safety and Immunogenicity of Acellular Pertussis Vaccine in Bone Marrow Transplant Recipients Unknown status NCT00336115 Phase 4
3 Vaccination Against Pertussis, Tetanus and Diphtheria in Patients Suffering From Rheumatoid Arthritis Unknown status NCT01301703 Phase 4
4 An Immunogenicity and Safety Study of Tetanus, Diphtheria and Acellular Pertussis Vaccine Booster Unknown status NCT00870350 Phase 4
5 Safety, Long Term Immunogenicity and Lot Consistency Study of Liquid Pentavalent Combination Vaccine Unknown status NCT00877357 Phase 4
6 Montelukast for Persistent Cough in Young People and Adults Unknown status NCT01279668 Phase 4 Montelukast;Placebo
7 Post-marketing Evaluation of Reactions Following Receipt of Recommended Adolescent Pertussis Vaccine Completed NCT00304265 Phase 4
8 Pertussis and Meningitis C Concomitant Vaccination in Adolescents Completed NCT02526394 Phase 4 Pertussis containing vaccine
9 Immunogenicity and Safety Study of a Booster Dose (5th) of Diphteria-Tetanus-Pertussis-Polio Vaccine Completed NCT00514059 Phase 4 Boostrix polio
10 Long-term Persistence of Hepatitis B and Pertussis Antibody Responses in Healthy 4- to 5 Year Old Children Previously Vaccinated With VAXELIS or INFANRIX Hexa Completed NCT02759354 Phase 4
11 Immune Responses in Adults to Revaccination With ADACEL® 10 Years After a Previous Dose Completed NCT00712959 Phase 4
12 A Trial to Evaluate the Safety and Immunogenicity of ADACEL® Vaccine in Persons 65 Years of Age and Older Completed NCT00457249 Phase 4
13 Immunogenicity and Safety of Concomitant Administration of RotaTeq™ (V260) and the Diphtheria, Tetanus, Pertussis and Inactivated Poliovirus Vaccine (DTP-IPV) in Healthy Japanese Infants (V260-060) Completed NCT01926015 Phase 4
14 Descriptive, Open-label, Multicenter Study of the Safety of Redosing With ADACEL® Vaccine Completed NCT00347958 Phase 4
15 Phase IV Interchangeability Study of a Liquid Pentavalent Combination Vaccine Completed NCT00674908 Phase 4
16 Study of Adacel® Vaccine Administered to Persons 10 Years of Age Completed NCT01311557 Phase 4
17 Post-licensure, Modified Double-blind, Multi-center Study Evaluating Safety and Immunogenicity of ADACEL® and BOOSTRIX® Completed NCT00319553 Phase 4
18 Post Marketing Surveillance for ADACEL™ in South Korea Completed NCT01137435 Phase 4
19 A Phase 4, Placebo-Controlled, Randomized Study to Evaluate the Immunogenicity and Safety of HPV and Tdap When Administered With MenACWY in Adolescents Completed NCT01424644 Phase 4
20 Safety and Immunogenicity in Adults of Revaccination With Adacel® Vaccine 10 Years After a Previous Dose Completed NCT01439165 Phase 4
21 Tdap Vaccine in Post-Partum Women Completed NCT01711645 Phase 4
22 Evaluation of Immunogenicity and Safety of the Diphtheria, Tetanus, Pertussis and Inactivated Poliovirus (DPT-IPV) Vaccine Squarekids™ Co-administered With GSK Biologicals' Human Rotavirus (HRV) Vaccine Rotarix™ (GSK444563) in Healthy Infants Completed NCT02907216 Phase 4
23 Randomized Study of Not Giving Diphteria-tetanus-pertussis Vaccination With or After Measles Vaccination Completed NCT00244673 Phase 4
24 Immunogenicity of Adacel® and BOOSTRIX® Vaccines in Adolescents Completed NCT01629589 Phase 4
25 A Trial Evaluating a 7-valent Pneumococcal Conjugate Vaccine Given With Diphtheria, Tetanus, and Acellular Pertussis Vaccine (DTaP) in Healthy Japanese Infants. Completed NCT01250756 Phase 4
26 Regulatory Post-Marketing Surveillance Study for TETRAXIM™ Completed NCT01437423 Phase 4
27 Study of DAPTACEL® Administered as a 5th Dose in 4 to 6-Year-Old Children Previously Immunized With PENTACEL™ Completed NCT00802867 Phase 4
28 US-licensed Combined Vaccine Against Tetanus & Diphtheria, Given With US-licensed Vaccine Against Meningococcal Disease Completed NCT00282295 Phase 4
29 Study of Menactra® in Healthy Subjects at 9 Months and Concomitantly With Pentacel® at 15 to 18 Months of Age Completed NCT01659996 Phase 4
30 Safety and Immunogenicity Study of a Liquid Pentavalent Combination Vaccine Completed NCT00617812 Phase 4
31 Concomitant Use of Hepatitis A Vaccine, Inactivated With Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate) and Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed Given to Healthy Children 15 Months of Age (V251-068) Completed NCT00289913 Phase 4
32 Study of Menactra® in US Adolescents When Administered Concomitantly With Tdap Vaccine Completed NCT00777257 Phase 4
33 Assessment of the Immunogenicity and Safety of PENTAXIM™ in Philippines Completed NCT00254917 Phase 4
34 Study to Assess if Quinvaxem Can be Interchanged With Other Pentavalent Vaccines During Standard Childhood Vaccination Completed NCT01357720 Phase 4
35 Immunogenicity and Safety of Sanofi Pasteur Pentaxim Combined Vaccine in Infants in Thailand Completed NCT00255021 Phase 4
36 Immunogenicity & Reactogenicity of Boostrix 10 Years After Previous Booster Vaccination. Completed NCT00610168 Phase 4
37 Immunogenicity and Safety of Booster Dose of BoostrixTM Polio Vaccine in Previously Boosted Adults Completed NCT01323959 Phase 4
38 Immunogenicity and Safety of TETRAXIM™ Given as a Booster Dose at 4 to 6 Years of Age Completed NCT01031303 Phase 4
39 Immunology of Non-specific Effects of Vaccine Completed NCT00168545 Phase 4
40 Evaluation of Boostrix™10 Years After Previous Booster Vaccination Completed NCT01147900 Phase 4
41 Antibody Persistence to REVAXIS or DT Polio and Immune Response to TETRAVAC-ACELLULAIRE Completed NCT01546909 Phase 4
42 Immunogenicity and Reactogenicity Study of BoostrixTM (dTpa) and Boostrix-IPV (dTpa-IPV) Completed NCT01294605 Phase 4
43 Safety of PENTAXIM® Given as a Three-Dose Primary Vaccination at 2, 3, and 4 Months of Age in Infants in China Completed NCT01491087 Phase 4
44 Safety and Immunogenicity of a Booster Dose of GSK Biological's Boostrix-Polio Vaccine Completed NCT00635128 Phase 4
45 Hepatitis B Vaccination in Infants Completed NCT01896596 Phase 4
46 Immunogenicity & Reactogenicity of Boostrix 10 Years After Previous Booster Vaccination Completed NCT00548171 Phase 4
47 Retrospective Survey of Safety of Fourth Dose Pentacel® in Children Completed NCT00772369 Phase 4
48 Immunogenicity and Safety of BoostrixTM Using a New Syringe in 10 to 15-year Old Adolescents Completed NCT01362322 Phase 4
49 A Study to Assess the Antibody Response of Healthy Chinese Children Who Have Been Vaccinated Previously With 4-doses of Prevenar (a Pneumococcal Vaccine) as Babies and Toddlers Completed NCT01298544 Phase 4
50 Study of a New Formulation of DTPa-HBV-IPV/Hib Vaccine Administered as a Booster Dose to 18-23 Months Old Children Completed NCT00611559 Phase 4

Search NIH Clinical Center for Pertussis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: whooping cough

Genetic Tests for Pertussis

Anatomical Context for Pertussis

MalaCards organs/tissues related to Pertussis:

39
Testes, T Cells, Monocytes, Neutrophil, Lung, B Cells, Liver

Publications for Pertussis

Articles related to Pertussis:

(show top 50) (show all 1176)
id Title Authors Year
1
The relationship between mucosal immunity, nasopharyngeal carriage, asymptomatic transmission and the resurgence of Bordetella pertussis. ( 28928960 )
2017
2
Emerging Bordetella pertussis Strains Induce Enhanced Signaling of Human Pattern Recognition Receptors TLR2, NOD2 and Secretion of IL-10 by Dendritic Cells. ( 28076445 )
2017
3
Characteristics of Bordetella pertussis infection among infantsand children admitted to paediatric intensive care units in Greece: A multicentre, 11-year study. ( 28058755 )
2017
4
Intention to accept pertussis vaccine among pregnant women in Karachi, Pakistan. ( 28863869 )
2017
5
Molecular and cellular signatures underlying superior immunity against Bordetella pertussis upon pulmonary vaccination. ( 28930286 )
2017
6
Dot map cartograms for detection of infectious disease outbreaks: an application to Q fever, the Netherlands and pertussis, Germany. ( 28681721 )
2017
7
Co-administration of BCG and Diphtheria-tetanus-pertussis (DTP) Vaccinations May Reduce Infant Mortality More Than the WHO-schedule of BCG First and Then DTP. A Re-analysis of Demographic Surveillance Data From Rural Bangladesh. ( 28784413 )
2017
8
Complete Genome Sequences of Bordetella pertussis Isolates with Novel Pertactin-Deficient Deletions. ( 28912323 )
2017
9
Tetanus, diphtheria, and acellular pertussis vaccination during pregnancy and reduced risk of infant acute respiratory infections. ( 28916245 )
2017
10
Negative Correlation between Circulating CD4(+)FOXP3(+)CD127(-) Regulatory T Cells and Subsequent Antibody Responses to Infant Measles Vaccine but Not Diphtheria-Tetanus-Pertussis Vaccine Implies a Regulatory Role. ( 28855899 )
2017
11
Preliminary studies on the use of pertussis toxin for the modulation of intravaginal SIV transmission in rhesus macaques. ( 28940591 )
2017
12
Assessing the social and environmental determinants of pertussis epidemics in Queensland, Australia: a Bayesian spatio-temporal analysis. ( 28091337 )
2017
13
Risk factors for pertussis in adults and teenagers in England. ( 28065204 )
2017
14
Immune persistence after pertussis vaccination. ( 28045580 )
2017
15
Illness Representations of Pertussis and Predictors of Child Vaccination Among Mothers in a Strict Vaccination Exemption State. ( 28884450 )
2017
16
Committee Opinion No. 718: Update on Immunization and Pregnancy: Tetanus, Diphtheria, and Pertussis Vaccination. ( 28832489 )
2017
17
Retinal haemorrhage in infants with pertussis. ( 28939637 )
2017
18
Using the 4 Pillarsa8c Practice Transformation Program to increase adolescent human papillomavirus, meningococcal, tetanus-diphtheria-pertussis and influenza vaccination. ( 28947346 )
2017
19
Committee Opinion No. 718 Summary: Update on Immunization and Pregnancy: Tetanus, Diphtheria, and Pertussis Vaccination. ( 28832480 )
2017
20
Diphtheria, pertussis, and tetanus: evidence-based management of pediatric patients in the emergency department ( 28749121 )
2017
21
Identification and characterization of a brilliant yellow pigment produced by Bordetella pertussis. ( 28906022 )
2017
22
Pertussis Maternal Immunization: Narrowing the Knowledge Gaps on the Duration of Transferred Protective Immunity and on Vaccination Frequency. ( 28932228 )
2017
23
When Escherichia coli doesn't fit the mold: A pertussis-like toxin with altered specificity. ( 28887436 )
2017
24
Risk of Pertussis in Relation to Degree of Prematurity in Children < 2 Years of Age. ( 28067717 )
2017
25
Effect of Prepregnancy Pertussis Vaccination in Young Infants. ( 28863468 )
2017
26
Re: Clinical Diagnosis of Bordetella Pertussis Infection: A Systematic Review. ( 28923822 )
2017
27
Resurgence of Pertussis and Emergence of the Ptxp3 Toxin Promoter Allele in South Italy. ( 28945679 )
2017
28
Impact of age and vaccination history on long-term serological responses after symptomatic B. pertussis infection, a high dimensional data analysis. ( 28091579 )
2017
29
Assessment of clinical symptoms in household contacts of confirmed pertussis cases. ( 28867343 )
2017
30
Diphtheria, pertussis, and tetanus: evidence-based management of pediatric patients in the emergency department [digest]. ( 28749625 )
2017
31
Block V RTX Domain of Adenylate Cyclase from Bordetella pertussis: A Conformationally Dynamic Scaffold for Protein Engineering Applications. ( 28926974 )
2017
32
Ric-8A-mediated stabilization of the trimeric G protein subunit GI+i is inhibited by pertussis toxin-catalyzed ADP-ribosylation. ( 28082199 )
2017
33
Demand- and supply-side determinants of diphtheria-pertussis-tetanus nonvaccination and dropout in rural India. ( 28081971 )
2017
34
A New Vaccine Delivery Vehicle and Adjuvant Candidate: Bordetella Pertussis Inactivated Whole Cells Entrapped in Alginate Microspheres. ( 28079006 )
2017
35
The Timing of Pertussis Cases in Unvaccinated Children in an Outbreak Year: Oregon 2012. ( 28088399 )
2017
36
Extensive swelling of the limb and systemic symptoms after a fourth dose of acellular pertussis containing vaccines in England in children aged 3-6years. ( 28017441 )
2017
37
Monitoring Pertussis Infections Using Internet Search Queries. ( 28874880 )
2017
38
Estimating Pertussis Susceptibility Among 0-23-Month-Old Children in the United States. Using National Immunization Survey (NIS) 2013. ( 28060041 )
2017
39
Hyperbiofilm Formation by Bordetella pertussis Strains Correlates with Enhanced Virulence Traits. ( 28893915 )
2017
40
Population-Based Pertussis Incidence and Risk Factors in Infants Less Than 6 Months in Nepal. ( 28073985 )
2017
41
Underdetection and underreporting of pertussis in children attended in primary health care centers: Do surveillance systems require improvement? ( 27184210 )
2016
42
Sex-Differential Non-Vaccine-Specific Immunological Effects of Diphtheria-Tetanus-Pertussis and Measles Vaccination. ( 27436422 )
2016
43
Association of Vitamin D Receptor Polymorphism with Susceptibility to Symptomatic Pertussis. ( 26894582 )
2016
44
State of inequality in diphtheria-tetanus-pertussis immunisation coverage in low-income and middle-income countries: a multicountry study of household health surveys. ( 27497954 )
2016
45
Employers' Views on Influenza and Tetanus-Diphtheria-Pertussis Vaccination in the Workplace. ( 27058495 )
2016
46
Undervaccination with diphtheria, tetanus, and pertussis vaccine: National trends and association with pertussis risk in young children. ( 27858500 )
2016
47
Pertussis: Where did we go wrong and what can we do about it? ( 27161992 )
2016
48
A Belgian Serosurveillance/Seroprevalence Study of Diphtheria, Tetanus and Pertussis Using a Luminex xMAP Technology-Based Pentaplex. ( 27171114 )
2016
49
Prevalence of Pertussis Antibodies in Maternal Blood, Cord Serum, and Infants From Mothers With and Those Without Tdap Booster Vaccination During Pregnancy in Argentina. ( 28040688 )
2016
50
Pertussis leukocytosis: mechanisms, clinical relevance and treatment. ( 27609461 )
2016

Variations for Pertussis

Expression for Pertussis

Search GEO for disease gene expression data for Pertussis.

Pathways for Pertussis

Pathways related to Pertussis according to KEGG:

37
id Name Kegg Source Accession
1 Pertussis hsa05133

Pathways related to Pertussis according to GeneCards Suite gene sharing:

(show top 50) (show all 195)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.22 CALM1 FOS IL10 IL1B IL6 ITGAM
2
Show member pathways
14.05 FOS GNA11 GNA14 GNA15 GNAI1 GNAZ
3
Show member pathways
14.04 FOS GNA11 GNA14 GNA15 GNAI1 GNAZ
4
Show member pathways
13.92 CALM1 FOS GNA11 GNA14 GNA15 GNAI1
5
Show member pathways
13.81 CALM1 FOS GNA11 GNA14 GNA15 GNAI1
6
Show member pathways
13.73 CALM1 FOS GNA11 GNA14 GNA15 IL10
7
Show member pathways
13.66 CALM1 GNAI1 GNAQ IL1B IL6 JUN
8
Show member pathways
13.61 CALM1 FOS GNA11 GNA14 GNA15 GNAI1
9
Show member pathways
13.57 CALM1 FOS IL10 IL1B IL6 ITGAM
10
Show member pathways
13.52 FOS GNA11 GNA14 GNA15 GNAI1 GNAZ
11
Show member pathways
13.51 CALM1 GNA11 GNA14 GNA15 GNAI1 GNAQ
12
Show member pathways
13.5 CALM1 GNA11 GNA14 GNA15 GNAI1 GNAZ
13
Show member pathways
13.47 FOS IL10 IL1B IL6 JUN MAPK1
14
Show member pathways
13.45 CALM1 FOS GNAI1 IL6 JUN MAPK1
15
Show member pathways
13.42 CALM1 FOS GNA11 GNAI1 GNAQ GNAZ
16
Show member pathways
13.31 CALM1 GNA11 GNA14 GNA15 GNAI1 GNAQ
17
Show member pathways
13.28 CALM1 GNA11 GNA14 GNA15 GNAI1 GNAZ
18
Show member pathways
13.27 FOS GNA11 GNA14 GNA15 GNAI1 IL6
19
Show member pathways
13.27 CALM1 FOS GNA11 GNA14 GNA15 GNAI1
20
Show member pathways
13.21 CALM1 FOS GNA11 GNA14 GNA15 GNAI1
21
Show member pathways
13.2 CALM1 FOS IL1B IL6 JUN MAPK1
22
Show member pathways
13.2 CALM1 FOS GNA11 GNA14 GNA15 GNAI1
23
Show member pathways
13.12 FOS ITGAM ITGB2 JUN MAPK1 MAPK10
24
Show member pathways
13.12 CALM1 FOS GNA11 GNA14 GNA15 GNAI1
25
Show member pathways
13.1 CALM1 FOS GNA11 GNA14 GNA15 GNAI1
26
Show member pathways
13.09 CALM1 FOS GNA11 GNAI1 GNAQ JUN
27
Show member pathways
13.06 FOS ITGAM ITGB2 JUN MAPK1 MAPK10
28
Show member pathways
13.04 CALM1 FOS GNA11 GNAI1 ITGAM ITGB2
29
Show member pathways
13.02 IL6 JUN MAPK1 MAPK10 TNF
30
Show member pathways
13.02 CALM1 GNA11 GNA14 GNA15 GNAI1 IL6
31
Show member pathways
13.02 FOS GNA11 GNA14 GNA15 GNAI1 GNAQ
32
Show member pathways
13.01 FOS IL1B IL6 JUN MAPK1 MAPK10
33
Show member pathways
12.98 CALM1 FOS GNA11 GNAI1 GNAQ MAPK1
34
Show member pathways
12.98 CALM1 FOS GNA11 GNAI1 GNAQ GNAZ
35
Show member pathways
12.94 CALM1 GNAI1 GNAQ ITGAM ITGB2 MAPK1
36
Show member pathways
12.94 CALM1 FOS GNA11 GNAI1 GNAQ GNAZ
37
Show member pathways
12.93 FOS GNA11 GNA14 GNA15 GNAI1 GNAZ
38
Show member pathways
12.92 FOS IL6 JUN MAPK1 TNF
39 12.91 FOS GNA11 GNAI1 GNAQ IL6 JUN
40 12.9 FOS IL1B JUN MAPK1 MAPK10 TNF
41
Show member pathways
12.89 CALM1 GNA11 GNA14 GNA15 GNAI1 GNAZ
42
Show member pathways
12.88 CALM1 FOS GNA15 IL10 JUN MAPK1
43
Show member pathways
12.86 FOS IL1B JUN MAPK1 MAPK10 TNF
44
Show member pathways
12.85 CALM1 IL1B IL6 TLR4 TNF
45
Show member pathways
12.83 FOS IL10 IL1B IL6 JUN MAPK1
46
Show member pathways
12.83 CALM1 FOS GNA11 GNAQ IL1B JUN
47
Show member pathways
12.8 CALM1 GNA11 GNA14 GNA15 GNAI1 GNAZ
48
Show member pathways
12.79 FOS IL10 IL1B IL6 MAPK1 TNF
49
Show member pathways
12.79 CALM1 FOS JUN MAPK1 MAPK10 TNF
50
Show member pathways
12.76 CALM1 FOS GNA11 GNAI1 GNAQ GNAZ

GO Terms for Pertussis

Cellular components related to Pertussis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription factor AP-1 complex GO:0035976 9.16 FOS JUN
2 external side of plasma membrane GO:0009897 9.13 IL6 TLR4 TNF
3 heterotrimeric G-protein complex GO:0005834 9.1 GNA11 GNA14 GNA15 GNAI1 GNAQ GNAZ
4 plasma membrane GO:0005886 10.03 GNA11 GNA14 GNA15 GNAI1 GNAQ GNAZ

Biological processes related to Pertussis according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.99 IL1B IL6 MAPK1 TLR4 TNF
2 Fc-epsilon receptor signaling pathway GO:0038095 9.98 FOS JUN MAPK1 MAPK10
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.97 IL1B TICAM1 TLR4 TNF
4 aging GO:0007568 9.96 FOS IL10 IL6 ITGB2 JUN
5 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.93 IL10 IL1B IL6 TNF
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.93 IL1B IL6 ITGB2 TICAM1 TLR4 TNF
7 cellular response to lipopolysaccharide GO:0071222 9.92 IL10 IL6 TICAM1 TLR4 TNF
8 activation of MAPK activity GO:0000187 9.91 IL1B MAPK1 MAPK10 TLR4 TNF
9 apoptotic signaling pathway GO:0097190 9.9 TICAM1 TLR4 TNF
10 positive regulation of JNK cascade GO:0046330 9.9 IL1B TLR4 TNF
11 response to glucocorticoid GO:0051384 9.9 IL10 IL6 TNF
12 response to mechanical stimulus GO:0009612 9.89 FOS IL6 JUN
13 response to cytokine GO:0034097 9.88 FOS IL6 JUN
14 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.88 TICAM1 TLR4 TNF
15 positive regulation of smooth muscle cell proliferation GO:0048661 9.87 IL6 JUN TNF
16 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007193 9.84 GNAI1 GNAZ OPRM1
17 positive regulation of interferon-gamma production GO:0032729 9.83 IL1B TLR4 TNF
18 cellular response to reactive oxygen species GO:0034614 9.82 FOS JUN MAPK1
19 cellular response to cadmium ion GO:0071276 9.81 FOS JUN MAPK1
20 positive regulation of interleukin-8 production GO:0032757 9.8 IL1B TLR4 TNF
21 negative regulation of interleukin-6 production GO:0032715 9.79 IL10 TLR4 TNF
22 positive regulation of NF-kappaB import into nucleus GO:0042346 9.78 IL1B TLR4 TNF
23 regulation of sequence-specific DNA binding transcription factor activity GO:0051090 9.78 FOS JUN MAPK1 MAPK10
24 adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007188 9.77 GNA11 GNA14 GNA15 GNAI1 GNAZ
25 positive regulation of chemokine production GO:0032722 9.75 IL6 TLR4 TNF
26 toll-like receptor 4 signaling pathway GO:0034142 9.74 ITGAM ITGB2 TLR4
27 platelet activation GO:0030168 9.73 GNA11 GNA14 GNA15 GNAQ IL6 MAPK1
28 phototransduction, visible light GO:0007603 9.72 GNA11 GNAQ
29 negative regulation of lipid storage GO:0010888 9.72 IL6 TNF
30 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.72 IL10 IL1B TNF
31 positive regulation of interleukin-6 production GO:0032755 9.72 IL1B IL6 TICAM1 TLR4 TNF
32 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.71 TLR4 TNF
33 endothelial cell apoptotic process GO:0072577 9.71 IL10 TNF
34 positive regulation of MHC class II biosynthetic process GO:0045348 9.71 IL10 TLR4
35 positive regulation of chemokine biosynthetic process GO:0045080 9.71 IL1B TICAM1 TNF
36 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.71 GNA11 GNA14 GNA15 GNAQ
37 entrainment of circadian clock GO:0009649 9.69 GNA11 GNAQ
38 regulation of establishment of endothelial barrier GO:1903140 9.69 IL1B TNF
39 negative regulation of MyD88-independent toll-like receptor signaling pathway GO:0034128 9.69 TICAM1 TLR4
40 positive regulation of interferon-beta biosynthetic process GO:0045359 9.68 TICAM1 TLR4
41 negative regulation of cytokine secretion involved in immune response GO:0002740 9.68 IL10 TNF
42 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.67 IL6 TNF
43 positive regulation of fever generation GO:0031622 9.66 IL1B TNF
44 sequestering of triglyceride GO:0030730 9.65 IL1B TNF
45 cellular extravasation GO:0045123 9.65 ITGB2 TNF
46 receptor biosynthetic process GO:0032800 9.64 IL10 TNF
47 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.64 IL1B TNF
48 regulation of melanocyte differentiation GO:0045634 9.61 GNA11 GNAQ
49 lipopolysaccharide-mediated signaling pathway GO:0031663 9.55 IL1B MAPK1 TICAM1 TLR4 TNF
50 positive regulation of nitric oxide biosynthetic process GO:0045429 9.43 IL1B IL6 ITGB2 TICAM1 TLR4 TNF

Molecular functions related to Pertussis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 signal transducer activity GO:0004871 9.86 GNA11 GNA14 GNA15 GNAI1 GNAQ GNAZ
2 GTP binding GO:0005525 9.85 GNA11 GNA14 GNA15 GNAI1 GNAQ GNAZ
3 GTPase activity GO:0003924 9.8 GNA11 GNA14 GNA15 GNAI1 GNAQ GNAZ
4 cytokine activity GO:0005125 9.76 IL10 IL1B IL6 TNF
5 G-protein coupled receptor binding GO:0001664 9.63 GNA11 GNA14 GNA15 GNAI1 GNAQ GNAZ
6 G-protein coupled serotonin receptor binding GO:0031821 9.43 GNAI1 GNAZ
7 G-protein beta/gamma-subunit complex binding GO:0031683 9.43 GNA11 GNA14 GNA15 GNAI1 GNAQ GNAZ
8 type 2A serotonin receptor binding GO:0031826 9.4 GNA11 GNAQ
9 guanyl nucleotide binding GO:0019001 9.1 GNA11 GNA14 GNA15 GNAI1 GNAQ GNAZ

Sources for Pertussis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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