MCID: PRV006
MIFTS: 52

Pervasive Developmental Disorder malady

Mental diseases, Fetal diseases categories
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Summaries for Pervasive Developmental Disorder

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8Disease Ontology, 44NINDS, 65Wikipedia, 33MalaCards
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NINDS:44 The diagnostic category of pervasive developmental disorders (PDD) refers to a group of disorders characterized by delays in the development of socialization and communication skills. Parents may note symptoms as early as infancy, although the typical age of onset is before 3 years of age. Symptoms may include problems with using and understanding language; difficulty relating to people, objects, and events; unusual play with toys and other objects; difficulty with changes in routine or familiar surroundings, and repetitive body movements or behavior patterns. Autism (a developmental brain disorder characterized by impaired social interaction and communication skills, and a limited range of activities and interests) is the most characteristic and best studied PDD. Other types of PDD include Asperger's Syndrome, Childhood Disintegrative Disorder, and Rett's Syndrome. Children with PDD vary widely in abilities, intelligence, and behaviors. Some children do not speak at all, others speak in limited phrases or conversations, and some have relatively normal language development. Repetitive play skills and limited social skills are generally evident. Unusual responses to sensory information, such as loud noises and lights, are also common.

MalaCards: Pervasive Developmental Disorder, also known as pervasive development disorder, is related to attention deficit hyperactivity disorder and mental retardation. An important gene associated with Pervasive Developmental Disorder is SCT (secretin), and among its related pathways are Monoamine Transport and Venlafaxine Pathway, Pharmacokinetics. The compounds m-chlorophenylpiperazine and mcpp have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related mouse phenotypes are craniofacial and hearing/vestibular/ear.

Disease Ontology:8 A developmental disorder of mental health that refers to a group of five disorders characterized by impairments in socialization and communication, as well as restricted interests and repetitive behaviors.

Wikipedia:65 The diagnostic category pervasive developmental disorders (PDD), as opposed to specific developmental... more...

Aliases & Classifications for Pervasive Developmental Disorder

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Sources:
8Disease Ontology, 44NINDS, 45Novoseek, 62UMLS, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Mental diseases


Aliases & Descriptions:

pervasive developmental disorder 8 45
pervasive development disorder 8 62
pervasive developmental disorders 44


External Ids:

Disease Ontology8 DOID:0060040
ICD9CM27 299.80
ICD1025 F84

Related Diseases for Pervasive Developmental Disorder

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17GeneCards, 18GeneDecks
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Diseases related to Pervasive Developmental Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 67)
idRelated DiseaseScoreTop Affiliating Genes
1attention deficit hyperactivity disorder31.2SLC6A4
2mental retardation31.1TBX1, NLGN3, NLGN4X, MECP2, FRAXA, FRAXE
3autistic disorder31.0SLC6A4, GABRB3, NLGN4X, NLGN3, SHANK2, MECP2
4atypical autism30.8NLGN4X, GABRB3, NLGN3, TMEM185A
5rett syndrome30.8MECP2, GABRB3
6intellectual disability30.6MECP2, NLGN4X, TMEM185A
7schizophrenia30.4SCT, MECP2, PRL, FOXP2, ARSA, SLC6A4
8asperger syndrome30.3NLGN3, NLGN4X, SLC6A4, MECP2
9pervasive developmental disorder not otherwise specified11.0
10autism spectrum disorder10.5
11bipolar disorder10.5
12landau-kleffner syndrome10.4
13childhood disintegrative disease10.3
14anxiety disorder10.3
15pandas10.3
16epsilon-trimethyllysine hydroxylase deficiency10.3
17autism susceptibility 1610.3
18autism susceptibility 1510.3
19autism susceptibility 1710.3
20autism 1810.3
21autism susceptibility, x-linked 210.3
22autism susceptibility, x-linked 110.3
23autism susceptibility, x-linked 310.3
24autism x-linked 510.3
25blindness10.3
26angelman syndrome10.2
27bruxism10.2
28obsessive-compulsive disorder10.2
29pancreatic agenesis10.2
30conduct disorder10.2
31neonatal diabetes mellitus10.2
32measles10.2
33anorexia nervosa10.2
34tuberous sclerosis10.2
35frontal lobe epilepsy10.2
36cerebritis10.2
37aphasia10.2
38apraxia10.2
39diabetes mellitus10.2
40inflammatory bowel disease10.2
41learning disability10.2
42pancreatitis10.2
43specific developmental disorder10.2
44autosomal dominant nocturnal frontal lobe epilepsy10.2
45childhood-onset schizophrenia10.2
46gigantism10.2
47neuroaxonal dystrophy, infantile10.2
48precocious puberty10.2
4917p11.2 microduplication syndrome10.2
50distal 16p11.2 microdeletion syndrome10.2

Graphical network of the top 20 diseases related to Pervasive Developmental Disorder:



Diseases related to pervasive developmental disorder

Symptoms for Pervasive Developmental Disorder

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Drugs & Therapeutics for Pervasive Developmental Disorder

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Pervasive Developmental Disorder

Search NIH Clinical Center for Pervasive Developmental Disorder

Genetic Tests for Pervasive Developmental Disorder

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Anatomical Context for Pervasive Developmental Disorder

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33MalaCards
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MalaCards organs/tissues related to Pervasive Developmental Disorder:

33
Brain, Testes, Eye, Cortex, Heart, Skin, Prefrontal cortex

Animal Models for Pervasive Developmental Disorder or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Pervasive Developmental Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053829.4SLC6A4, GABRB3, TBX1, FOXP2, MECP2
2MP:00053778.8ABCB1, MECP2, FOXP2, TBX1, GABRB3, ARSA
3MP:00030128.5ABCB1, SHANK2, MECP2, FOXP2, NLGN3, GABRB3
4MP:00053767.6ABCB1, SCT, PRL, MECP2, FOXP2, TBX1
5MP:00053867.1ARSA, ABCB1, SHANK2, SCT, PRL, MECP2
6MP:00036317.1MECP2, PRL, SCT, SHANK2, ABCB1, FOXP2

Publications for Pervasive Developmental Disorder

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52PubMed
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Articles related to Pervasive Developmental Disorder:

(show top 50)    (show all 247)
idTitleAuthorsYear
1
Yokukansan (TJ-54) for irritability associated with pervasive developmental disorder in children and adolescents: a 12-week prospective, open-label study. (23782127)
2013
2
Pervasive developmental disorder in the children of immigrant parents: comparison of different assessment instruments. (24394875)
2013
3
Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified. (24130822)
2013
4
Sexual obsessions, compulsions, suicidality and homicidality in an adolescent diagnosed with bipolar disorder not otherwise specified, obsessive-compulsive disorder, pervasive developmental disorder not otherwise specified, and mild mental retardation. (22612525)
2012
5
Novel AGTR2 missense mutation in a Japanese boy with severe mental retardation, pervasive developmental disorder, and epilepsy. (22269148)
2012
6
Application of DSM-5 criteria for autism spectrum disorder to three samples of children with DSM-IV diagnoses of pervasive developmental disorders. (23032385)
2012
7
Buspirone for bruxism in a child with pervasive developmental disorder-not otherwise specified. (22136097)
2011
8
Epilepsy in pervasive developmental disorder without brain MRI abnormalities. (20863637)
2011
9
Possible evidence for a fall in the prevalence of high-functioning pervasive developmental disorder with age? (22937245)
2011
10
Analysis of Copper and Zinc Plasma Concentration and the Efficacy of Zinc Therapy in Individuals with Asperger's Syndrome, Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) and Autism. (22174567)
2011
11
Aripiprazole improves social interaction in Taiwanese children with pervasive developmental disorder. (20438675)
2010
12
Pervasive developmental disorder behavior in adolescents with intellectual disability and co-occurring somatic chronic diseases. (19948390)
2010
13
Retraction--Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. (20137807)
2010
14
Clinical features of epilepsy with pervasive developmental disorder. (20708864)
2010
15
An open-label trial of topiramate in the treatment of skin picking in pervasive developmental disorder not otherwise specified. (20694122)
2010
16
Targeting social skills deficits in an adolescent with pervasive developmental disorder. (20514202)
2009
17
Pathways to psychosis: a comparison of the pervasive developmental disorder subtype Multiple Complex Developmental Disorder and the "At Risk Mental State". (18055179)
2008
18
Editorial review: Shifting views on juvenile bipolar disorder and pervasive developmental disorder. (18520735)
2008
19
Injury treatment among children with autism or pervasive developmental disorder. (17690968)
2008
20
Cognitive profile difference between normally intelligent children with Asperger's disorder and those with pervasive developmental disorder not otherwise specified. (19068006)
2008
21
Abnormal spatial frequency processing in high-functioning children with pervasive developmental disorder (PDD). (17591458)
2007
22
Visual completion and complexity of visual shape in children with pervasive developmental disorder. (17136302)
2007
23
Epilepsy in patients with pervasive developmental disorder not otherwise specified. (17940246)
2007
24
Integrity of lateral and feedbackward connections in visual processing in children with pervasive developmental disorder. (17101159)
2007
25
Effects of object complexity and type on the gaze behavior of children with pervasive developmental disorder. (17628272)
2007
26
Electrocortical reflections of face and gaze processing in children with pervasive developmental disorder. (17073985)
2006
27
The metaphor and sarcasm scenario test: a new instrument to help differentiate high functioning pervasive developmental disorder from attention deficit/hyperactivity disorder. (15165670)
2004
28
Pseudologia Fantastica associated with Pervasive Developmental Disorder. (12108140)
2002
29
Increased prevalence of pervasive developmental disorders in children with slight arylsulfatase A deficiency. (12427515)
2002
30
Prolactin levels in young children with pervasive developmental disorders during risperidone treatment. (11838821)
2001
31
Impact of music therapy on the communication skills of toddlers with pervasive developmental disorder. (11458864)
2001
32
Olanzapine use in subjects with pervasive developmental disorder displaying aggression and/or self-mutilation. (15990518)
2001
33
Helping the patient who has pervasive developmental disorder. (11715674)
2001
34
Parent-directed, intensive early intervention for children with pervasive developmental disorder. (10983784)
2000
35
The classification of autism, Asperger's syndrome, and pervasive developmental disorder. (11086556)
2000
36
How unspecified are disorders of children with a pervasive developmental disorder not otherwise specified? A study of social problems in children with PDD-NOS and ADHD. (11095039)
2000
37
Children with PDD need to be evaluated by clinical geneticists. Pervasive developmental disorder. (10071950)
1999
38
Familial factors influence level of functioning in pervasive developmental disorder. (10361794)
1999
39
Lack of benefit of a single dose of synthetic human secretin in the treatment of autism and pervasive developmental disorder. (10588965)
1999
40
Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. (9500320)
1998
41
Outcomes of genetic evaluation in children with pervasive developmental disorder. (9809261)
1998
42
Emotional role-taking abilities of children with a pervasive developmental disorder not otherwise specified. (7782410)
1995
43
The pervasive developmental disorder spectrum: a case illustration. (8443614)
1993
44
Subclassification of children with autism and pervasive developmental disorder: a questionnaire based on Wing's subgrouping scheme. (8331045)
1993
45
Treatment strategies for a case of concurrent pervasive developmental disorder and cerebral gigantism. (2055890)
1991
46
Acquired aphasia with convulsive disorder: a pervasive developmental disorder variant. (1700988)
1990
47
A five-year follow-up of preschool children diagnosed as having an atypical pervasive developmental disorder. (2600185)
1989
48
Low-dose neuroleptic therapy for children with childhood-onset pervasive developmental disorder. (3344846)
1988
49
Tourette syndrome, atypical pervasive developmental disorder and Ganser syndrome in a 15-year-old, visually impaired, mentally retarded boy. (3855681)
1985
50
Age of recognition of pervasive developmental disorder. (4073310)
1985

Variations for Pervasive Developmental Disorder

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Expression for genes affiliated with Pervasive Developmental Disorder

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pervasive Developmental Disorder

Search GEO for disease gene expression data for Pervasive Developmental Disorder.

Pathways for genes affiliated with Pervasive Developmental Disorder

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Sources:
50PathCards, 38NCBI BioSystems Database, 51PharmGKB, 55Reactome, 12EMD Millipore, 54R&D Systems
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Compounds for genes affiliated with Pervasive Developmental Disorder

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 51PharmGKB, 24HMDB, 3BitterDB, 61Tocris Bioscience
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Compounds related to Pervasive Developmental Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1m-chlorophenylpiperazine4510.3SLC6A4, PRL
2mcpp4510.3SLC6A4, PRL
3pindolol45 29 1112.3SLC6A4, PRL
4mdma4510.3SLC6A4, PRL
5amoxapine29 45 1112.2SLC6A4, PRL
6mhpg4510.2PRL, SLC6A4
75-hydroxytryptophan4510.2PRL, SLC6A4
8protriptyline51 1111.2SLC6A4, ABCB1
9ivermectin45 1111.1ABCB1, GABRB3
10reboxetine45 29 1112.1SLC6A4, ABCB1
11sodium bicarbonate45 1111.1SLC6A4, SCT
12amantadine45 1111.1ABCB1, SCT
13gaba4510.1SLC6A4, GABRB3, MECP2, SCT
14trazodone45 29 1112.1ABCB1, SLC6A4
15maprotiline45 51 1112.1ABCB1, SLC6A4
16mirtazapine45 51 1112.1PRL, SLC6A4
17homovanillic acid45 2411.0PRL, SLC6A4
18dextromethorphan3 51 24 1113.0ABCB1, SLC6A4
19nefazodone45 51 1112.0ABCB1, SLC6A4
20fenfluramine45 29 1112.0PRL, SLC6A4
21flupenthixol45 51 1112.0PRL, ABCB1
22fluphenazine29 45 51 1112.9ABCB1, PRL
235-hydroxytryptamine459.9PRL, TDO2, SLC6A4
24domperidone45 29 1111.9ABCB1, PRL
25buspirone45 29 1111.8PRL, SCT, ABCB1
26pimozide29 45 51 1112.8PRL, ABCB1
27naltrexone45 29 51 1112.8PRL, SCT, ABCB1
28trimipramine45 51 1111.8ABCB1, PRL, SLC6A4
29clomipramine45 51 1111.8SLC6A4, PRL, ABCB1
30paroxetine45 51 29 1112.8ABCB1, PRL, SLC6A4
31quetiapine45 51 29 24 1113.8SLC6A4, PRL, ABCB1
32citalopram45 51 24 1112.8ABCB1, PRL, SLC6A4
33paliperidone45 1110.8ABCB1, PRL
34olanzapine45 51 29 24 1113.8SLC6A4, PRL, ABCB1
35nitrazepam45 1110.8GABRB3, ABCB1
36clozapine45 29 51 1112.8SLC6A4, PRL, ABCB1
37haloperidol45 51 29 3 1113.7ABCB1, PRL, SLC6A4
38estrone45 29 24 1112.7ARSA, PRL, ABCB1
39sertraline45 29 51 24 1113.6ABCB1, SLC6A4
40risperidone45 51 29 61 24 1114.6SLC6A4, PRL, SCT, ABCB1
41fluoxetine45 51 29 1112.6ABCB1, SCT, PRL, SLC6A4
42clonidine45 51 29 1112.6ABCB1, SCT, PRL, SLC6A4
43arginine459.6SLC6A4, TDO2, MECP2, PRL, SCT
44epinephrine45 24 1111.6ABCB1, SCT, PRL, SLC6A4
45dihydrotestosterone45 29 24 1112.6ABCB1, PRL, SLC6A4
46toremifene45 1110.6ABCB1, PRL
47alanine459.6MECP2, FOXP2, TDO2, SLC6A4, ARSA
48glutamate459.5SHANK2, SCT, MECP2, FOXP2, SLC6A4
49fluvoxamine45 51 1111.4SLC6A4, ABCB1
50testosterone45 61 24 1112.4ABCB1, SCT, PRL, MECP2, SLC6A4

GO Terms for genes affiliated with Pervasive Developmental Disorder

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16Gene Ontology
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Cellular components related to Pervasive Developmental Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1excitatory synapseGO:0600769.9NLGN4X, NLGN3
2postsynaptic membraneGO:0452119.7GABRB3, NLGN4X, SHANK2
3cell junctionGO:0300549.1GABRB3, NLGN4X, NLGN3, SHANK2

Biological processes related to Pervasive Developmental Disorder according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1presynaptic membrane assemblyGO:09710510.2NLGN3, NLGN4X
2regulation of respiratory gaseous exchange by neurological system processGO:00208710.1NLGN3, MECP2
3cerebellum developmentGO:02154910.1NLGN4X, FOXP2, MECP2
4neuron cell-cell adhesionGO:00715810.1NLGN4X, NLGN3
5visual learningGO:00854210.1NLGN3, MECP2, SCT
6positive regulation of mesenchymal cell proliferationGO:00205310.0TBX1, FOXP2
7negative regulation of neuron apoptotic processGO:04352410.0SCT, MECP2, GABRB3
8positive regulation of synapse assemblyGO:0519659.9NLGN3, MECP2
9long-term synaptic potentiationGO:0602919.9MECP2, SHANK2
10vocalization behaviorGO:0716259.9NLGN4X, NLGN3, SHANK2
11adult behaviorGO:0305349.8SHANK2, NLGN3, NLGN4X
12learningGO:0076129.8SHANK2, NLGN3, NLGN4X
13synapse assemblyGO:0074169.8NLGN3, MECP2, SHANK2
14synapse organizationGO:0508089.7NLGN4X, NLGN3
15social behaviorGO:0351769.2SLC6A4, SHANK2, MECP2, TBX1, NLGN3, NLGN4X

Molecular functions related to Pervasive Developmental Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neurexin family protein bindingGO:04204310.0NLGN4X, NLGN3

Products for genes affiliated with Pervasive Developmental Disorder

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  • Antibodies
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Sources for Pervasive Developmental Disorder

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet