MCID: PRV006
MIFTS: 43

Pervasive Developmental Disorder malady

Neuronal category

Summaries for Pervasive Developmental Disorder

Sources:
8Disease Ontology, 44NINDS, 64Wikipedia, 33MalaCards
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NINDS:44 The diagnostic category of pervasive developmental disorders (PDD) refers to a group of disorders characterized by delays in the development of socialization and communication skills. Parents may note symptoms as early as infancy, although the typical age of onset is before 3 years of age. Symptoms may include problems with using and understanding language; difficulty relating to people, objects, and events; unusual play with toys and other objects; difficulty with changes in routine or familiar surroundings, and repetitive body movements or behavior patterns. Autism (a developmental brain disorder characterized by impaired social interaction and communication skills, and a limited range of activities and interests) is the most characteristic and best studied PDD. Other types of PDD include Asperger's Syndrome, Childhood Disintegrative Disorder, and Rett's Syndrome. Children with PDD vary widely in abilities, intelligence, and behaviors. Some children do not speak at all, others speak in limited phrases or conversations, and some have relatively normal language development. Repetitive play skills and limited social skills are generally evident. Unusual responses to sensory information, such as loud noises and lights, are also common.

MalaCards: Pervasive Developmental Disorder, also known as pervasive development disorder, is related to attention deficit hyperactivity disorder and autistic disorder. An important gene associated with Pervasive Developmental Disorder is SCT (secretin), and among its related pathways is GABA A receptor activation. The compounds protriptyline and Zimelidine have been mentioned in the context of this disorder. Related mouse phenotypes are no phenotypic analysis and hearing/vestibular/ear.

Disease Ontology:8 A developmental disorder of mental health that refers to a group of five disorders characterized by impairments in socialization and communication, as well as restricted interests and repetitive behaviors.

Wikipedia:64 The diagnostic category pervasive developmental disorders (PDD), as opposed to specific developmental... more...

Aliases & Classifications for Pervasive Developmental Disorder

Sources:
8Disease Ontology, 44NINDS, 45Novoseek, 61UMLS, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

pervasive developmental disorder 8 45
pervasive development disorder 8 61
pervasive developmental disorders 44


External Ids:

Disease Ontology8 DOID:0060040
ICD9CM27 299.80
ICD1025 F84

Related Diseases for Pervasive Developmental Disorder

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pervasive Developmental Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1attention deficit hyperactivity disorder31.1SLC6A4
2autistic disorder31.1SLC6A4, NLGN4X, NLGN3, FOXP2, SCT, GABRB3
3mental retardation30.9NLGN4X, FRAXA, NLGN3, TBX1, FRAXE, MECP2
4bipolar disorder30.7SLC6A4, TBX1
5asperger syndrome30.7NLGN4X, MECP2, NLGN3, SLC6A4
6down syndrome30.4MECP2, ARSA
7atypical autism30.4NLGN4X, NLGN3, GABRB3, TMEM185A
8rett syndrome30.2GABRB3, MECP2
9developmental disabilities30.2FOXP2, SCT, MECP2
10anorexia nervosa30.2SLC6A4, PRL
11specific developmental disorder10.6
12autism spectrum disorder10.5
13anxiety disorder10.5
14pervasive developmental disorder not otherwise specified10.5
15landau-kleffner syndrome10.4
16sleep disorder10.4
17schizophreniform disorder10.3
18n syndrome10.3
19speech disorder10.3
20tic disorder10.3
21pandas10.3
22epsilon-trimethyllysine hydroxylase deficiency10.3
23autism susceptibility 1610.3
24autism susceptibility 1510.3
25autism susceptibility 1710.3
26autism 1810.3
27autism susceptibility, x-linked 210.3
28autism susceptibility, x-linked 110.3
29autism susceptibility, x-linked 310.3
30autism x-linked 510.3
31bruxism10.2
32angelman syndrome10.2
33tuberous sclerosis10.2
34frontal lobe epilepsy10.2
35obsessive-compulsive disorder10.2
36adjustment disorder10.2
37pain disorder10.2
38conduct disorder10.2
39neonatal diabetes mellitus10.2
40measles10.2
41aphasia10.2
42apraxia10.2
43autosomal dominant nocturnal frontal lobe epilepsy10.2
44childhood-onset schizophrenia10.2
45pancreatic agenesis10.2
46precocious puberty10.2
47gigantism10.2
48neuroaxonal dystrophy, infantile10.2
49mental retardation epilepsy10.2
50seizure disorder10.2

Graphical network of the top 20 diseases related to Pervasive Developmental Disorder:



Diseases related to pervasive developmental disorder

Clinical Features for Pervasive Developmental Disorder

Drugs & Therapeutics for Pervasive Developmental Disorder

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pervasive Developmental Disorder

Drug clinical trials:

Search ClinicalTrials for Pervasive Developmental Disorder

Search NIH Clinical Center for Pervasive Developmental Disorder

Search CenterWatch for Pervasive Developmental Disorder

Genetic Tests for Pervasive Developmental Disorder

Anatomical Context for Pervasive Developmental Disorder

Animal Models for Pervasive Developmental Disorder or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Pervasive Developmental Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.8ABCB1, SHANK2, MECP2, GABRB3, FOXP2, NLGN3
2MP:00053778.6FOXP2, GABRB3, ARSA, MECP2, TBX1, ABCB1
3MP:00053867.0TDO2, NLGN3, FOXP2, SCT, GABRB3, ARSA
4MP:00036316.9ARSA, GABRB3, SCT, FOXP2, NLGN3, MECP2

Publications for Pervasive Developmental Disorder

Sources:
51PubMed
See all sources

Articles related to Pervasive Developmental Disorder:

(show top 50)    (show all 247)
idTitleAuthorsYear
1
Yokukansan (TJ-54) for irritability associated with pervasive developmental disorder in children and adolescents: a 12-week prospective, open-label study. (23782127)
2013
2
Diagnostic Boundaries of Autism Disorder Vs Pervasive Developmental Disorder Nos: Comparative Observational Study and Literature Review. (24050746)
2013
3
Novel AGTR2 missense mutation in a Japanese boy with severe mental retardation, pervasive developmental disorder, and epilepsy. (22269148)
2012
4
Is long-term prognosis for pervasive developmental disorder not otherwise specified different from prognosis for autistic disorder? Findings from a 30-year follow-up study. (21713590)
2012
5
Executive function in children with pervasive developmental disorder and attention-deficit/hyperactivity disorder assessed by the Keio version of the Wisconsin card sorting test. (21917389)
2012
6
Multi-channel near-infrared spectroscopy shows reduced activation in the prefrontal cortex during facial expression processing in pervasive developmental disorder. (22250607)
2012
7
Is recovery from a pervasive developmental disorder possible? (22353321)
2012
8
Buspirone for bruxism in a child with pervasive developmental disorder-not otherwise specified. (22136097)
2011
9
Analysis of Copper and Zinc Plasma Concentration and the Efficacy of Zinc Therapy in Individuals with Asperger's Syndrome, Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) and Autism. (22174567)
2011
10
The relationship between race and challenging behaviours in infants and toddlers with autistic disorder and pervasive developmental disorder-not otherwise specified. (21732805)
2011
11
Aripiprazole improves social interaction in Taiwanese children with pervasive developmental disorder. (20438675)
2010
12
Clinical features of epilepsy with pervasive developmental disorder. (20708864)
2010
13
An open-label trial of topiramate in the treatment of skin picking in pervasive developmental disorder not otherwise specified. (20694122)
2010
14
Pharmacological management in children and adolescents with pervasive developmental disorder. (20047454)
2010
15
Obsessional and atypical tic symptoms in an adolescent with complex Tourette's disorder and atypical pervasive developmental disorder not otherwise specified. (20578936)
2010
16
Possible influence of variant of the P-glycoprotein gene (MDR1/ABCB1) on clinical response to guanfacine in children with pervasive developmental disorders and hyperactivity. (20166790)
2010
17
A preliminary study on screening prevalence of pervasive developmental disorder in schoolchildren in Iran. (17879153)
2008
18
Abnormal spatial frequency processing in high-functioning children with pervasive developmental disorder (PDD). (17591458)
2007
19
Sleep disturbance and its relation to DSM-IV psychiatric symptoms in preschool-age children with pervasive developmental disorder and community controls. (17621477)
2007
20
Facial electromyographic responses to emotional information from faces and voices in individuals with pervasive developmental disorder. (17995488)
2007
21
Face processing in Pervasive Developmental Disorder (PDD): the roles of expertise and spatial frequency. (17636350)
2007
22
A genetic etiology of pervasive developmental disorder guides treatment. (17403969)
2007
23
Pervasive developmental disorder, behavior problems, and psychotropic drug use in children and adolescents with mental retardation. (17142506)
2006
24
Does pervasive developmental disorder protect children and adolescents against drug and alcohol use? (16604379)
2006
25
Empathic accuracy in adults with a pervasive developmental disorder during an unstructured conversation with a typically developing stranger. (16167090)
2005
26
A social adjustment enhancement intervention for high functioning autism, Asperger's syndrome, and pervasive developmental disorder NOS. (15679185)
2004
27
Adaptive behavior in autism and Pervasive Developmental Disorder-Not Otherwise Specified: microanalysis of scores on the Vineland Adaptive Behavior Scales. (15162940)
2004
28
Open-label study of olanzapine in children with pervasive developmental disorder. (12352267)
2002
29
Impact of music therapy on the communication skills of toddlers with pervasive developmental disorder. (11458864)
2001
30
Advancing advanced mind-reading tests: empathic accuracy in adults with a pervasive developmental disorder. (11280423)
2001
31
Pervasive developmental disorders and GABAergic system in patients with inverted duplicated chromosome 15. (11785506)
2001
32
Landau-Kleffner syndrome with onset at 18 months and an initial diagnosis of pervasive developmental disorder. (10817490)
2000
33
Familial factors influence level of functioning in pervasive developmental disorder. (10361794)
1999
34
Lack of benefit of a single dose of synthetic human secretin in the treatment of autism and pervasive developmental disorder. (10588965)
1999
35
Reliability and accuracy of differentiating pervasive developmental disorder subtypes. (9519632)
1998
36
Timing of social gaze behavior in children with a pervasive developmental disorder. (9656131)
1998
37
A syndrome of seizures and pervasive developmental disorder associated with excessive cellular nucleotidase activity. (9598171)
1998
38
Intensive behavioral treatment for preschoolers with severe mental retardation and pervasive developmental disorder. (9394133)
1997
39
Risperidone in children and adolescents with pervasive developmental disorder: pilot trial and follow-up. (9466234)
1997
40
Lack of expansion of triplet repeats in the FMR1, FRAXE, and FRAXF loci in male multiplex families with autism and pervasive developmental disorders. (8844091)
1996
41
Assessing the relationship between affective responsivity and social interaction in children with pervasive developmental disorder. (8331052)
1993
42
Differentiating pervasive developmental disorder not otherwise specified from autism and language disorders. (7681820)
1993
43
Birth order effects on nonverbal IQ in families with multiple incidence of autism or pervasive developmental disorder. (1483984)
1992
44
Autism is not necessarily a pervasive developmental disorder. (2044858)
1991
45
DSM-III and DSM-III-R diagnosis of autism and pervasive developmental disorder in nursery school children. (2295564)
1990
46
Pervasive developmental disorder in monozygotic twins. (2273017)
1990
47
Monoamines in autism: an update of neurochemical research on a pervasive developmental disorder. (3309489)
1987
48
Use of lithium and flupenthixol in a patient with pervasive developmental disorder. (3963264)
1986
49
Use of lithium and flupenthixol in a patient with pervasive developmental disorder. (3950263)
1986
50
Inquiry into the incidence of hyperlexia in a statewide population of children with pervasive developmental disorder. (4048337)
1985

Genetic Variations for Pervasive Developmental Disorder

Expression for genes affiliated with Pervasive Developmental Disorder

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pervasive Developmental Disorder

Search GEO for disease gene expression data for Pervasive Developmental Disorder.

Pathways for genes affiliated with Pervasive Developmental Disorder

Sources:
54Reactome, 12EMD Millipore, 53R&D Systems
See all sources

Pathways related to Pervasive Developmental Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8GABRB3, NLGN3, NLGN4X

Compounds for genes affiliated with Pervasive Developmental Disorder

Sources:
50PharmGKB, 11DrugBank, 45Novoseek, 29IUPHAR, 2BitterDB, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Pervasive Developmental Disorder according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1protriptyline50 1111.3SLC6A4, ABCB1
2Zimelidine1110.3SLC6A4, ABCB1
3Levomilnacipran1110.3ABCB1, SLC6A4
4reboxetine45 29 1112.3SLC6A4, ABCB1
5ivermectin45 1111.3GABRB3, ABCB1
6trazodone45 29 1112.2SLC6A4, ABCB1
7amantadine45 1111.2SCT, ABCB1
8dextromethorphan2 50 11 2413.2ABCB1, SLC6A4
9maprotiline45 1111.2ABCB1, SLC6A4
10citalopram50 45 11 2413.1SLC6A4, PRL
11m-chlorophenylpiperazine4510.1PRL, SLC6A4
12mcpp4510.1SLC6A4, PRL
13pindolol45 29 1112.1SLC6A4, PRL
14nefazodone45 50 1112.1ABCB1, SLC6A4
15amoxapine45 29 1112.1PRL, SLC6A4
16mdma4510.1PRL, SLC6A4
17sodium bicarbonate45 1111.1SLC6A4, SCT
18gaba4510.1SLC6A4, MECP2, GABRB3, SCT
19mhpg4510.0PRL, SLC6A4
205-hydroxytryptophan4510.0PRL, SLC6A4
21flupenthixol45 50 1111.9ABCB1, PRL
22fluphenazine29 45 1111.9ABCB1, PRL
23sertraline45 29 50 11 2413.9ABCB1, SLC6A4
24mirtazapine50 45 1111.8PRL, SLC6A4
25buspirone45 29 1111.8SCT, PRL, ABCB1
26naltrexone45 50 29 1112.8SCT, PRL, ABCB1
27trimipramine50 45 1111.8SLC6A4, ABCB1, PRL
28clomipramine45 50 1111.8PRL, ABCB1, SLC6A4
29paroxetine45 50 29 1112.8PRL, ABCB1, SLC6A4
30domperidone45 29 1111.8ABCB1, PRL
31pimozide29 50 45 1112.7PRL, ABCB1
32clozapine45 29 50 1112.7SLC6A4, ABCB1, PRL
33haloperidol45 29 2 50 1113.7SLC6A4, ABCB1, PRL
34paliperidone45 1110.6PRL, ABCB1
35homovanillic acid45 2410.6PRL, SLC6A4
36risperidone29 45 50 60 11 2414.6SLC6A4, ABCB1, PRL, SCT
37estrone45 29 11 2412.6ARSA, PRL, ABCB1
38fluoxetine50 45 29 1112.6SCT, PRL, ABCB1, SLC6A4
39clonidine45 29 1111.6SLC6A4, ABCB1, PRL, SCT
40epinephrine45 11 2411.5SCT, PRL, ABCB1, SLC6A4
41fenfluramine29 45 1111.4PRL, SLC6A4
42testosterone45 60 11 2412.3SCT, MECP2, PRL, ABCB1, SLC6A4

GO Terms for genes affiliated with Pervasive Developmental Disorder

Sources:
16Gene Ontology
See all sources

Cellular components related to Pervasive Developmental Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1excitatory synapseGO:0600769.7NLGN3, NLGN4X
2cell junctionGO:0300549.4SHANK2, GABRB3, NLGN3, NLGN4X

Biological processes related to Pervasive Developmental Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of synapse assemblyGO:05196510.0MECP2, NLGN3
2cerebellum developmentGO:0215499.9MECP2, NLGN4X, FOXP2
3presynaptic membrane assemblyGO:0971059.9NLGN3, NLGN4X
4visual learningGO:0085429.8NLGN3, SCT, MECP2
5regulation of respiratory gaseous exchange by neurological system processGO:0020879.7NLGN3, MECP2
6social behaviorGO:0351769.4SLC6A4, MECP2, TBX1, NLGN4X, NLGN3

Molecular functions related to Pervasive Developmental Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neurexin family protein bindingGO:04204310.0NLGN3, NLGN4X

Products for genes affiliated with Pervasive Developmental Disorder

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pervasive Developmental Disorder

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet