MCID: PRV006
MIFTS: 53

Pervasive Developmental Disorder malady

Mental diseases, Fetal diseases categories
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Summaries for Pervasive Developmental Disorder

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NINDS:43 The diagnostic category of pervasive developmental disorders (PDD) refers to a group of disorders characterized by delays in the development of socialization and communication skills. Parents may note symptoms as early as infancy, although the typical age of onset is before 3 years of age. Symptoms may include problems with using and understanding language; difficulty relating to people, objects, and events; unusual play with toys and other objects; difficulty with changes in routine or familiar surroundings, and repetitive body movements or behavior patterns. Autism (a developmental brain disorder characterized by impaired social interaction and communication skills, and a limited range of activities and interests) is the most characteristic and best studied PDD. Other types of PDD include Asperger's Syndrome, Childhood Disintegrative Disorder, and Rett's Syndrome. Children with PDD vary widely in abilities, intelligence, and behaviors. Some children do not speak at all, others speak in limited phrases or conversations, and some have relatively normal language development. Repetitive play skills and limited social skills are generally evident. Unusual responses to sensory information, such as loud noises and lights, are also common.

MalaCards based summary: Pervasive Developmental Disorder, also known as pervasive developmental disorders, is related to attention deficit hyperactivity disorder and rett syndrome. An important gene associated with Pervasive Developmental Disorder is SCT (secretin), and among its related pathways are Monoamine Transport and Venlafaxine Pathway, Pharmacokinetics. The compounds m-chlorophenylpiperazine and mcpp have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related mouse phenotypes are craniofacial and hearing/vestibular/ear.

Disease Ontology:8 A developmental disorder of mental health that refers to a group of five disorders characterized by impairments in socialization and communication, as well as restricted interests and repetitive behaviors.

Wikipedia:65 The diagnostic category pervasive developmental disorders (PDD), as opposed to specific developmental... more...

Aliases & Classifications for Pervasive Developmental Disorder

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 43NINDS, 27ICD9CM, 25ICD10
See all sources

Pervasive Developmental Disorder, Aliases & Descriptions:

Name: Pervasive Developmental Disorder 8 44 62
Pervasive Developmental Disorders 43 62
 
Pervasive Development Disorder 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:0060040
ICD9CM27 299.80
ICD1025 F84

Related Diseases for Pervasive Developmental Disorder

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Diseases related to Pervasive Developmental Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 70)
idRelated DiseaseScoreTop Affiliating Genes
1attention deficit hyperactivity disorder31.5SLC6A4
2rett syndrome31.2MECP2, GABRB3
3mental retardation31.0TBX1, NLGN3, NLGN4X, MECP2, FRAXA, FRAXE
4atypical autism31.0NLGN4X, GABRB3, NLGN3, TMEM185A
5autistic disorder30.8SLC6A4, GABRB3, NLGN4X, NLGN3, SHANK2, MECP2
6asperger syndrome30.6NLGN3, NLGN4X, SLC6A4, MECP2
7schizophrenia30.1SCT, MECP2, PRL, FOXP2, ARSA, SLC6A4
8pervasive developmental disorder not otherwise specified11.0
9autism spectrum disorder10.6
10bipolar disorder10.5
11premature ejaculation10.5SLC6A4
12antisocial personality disorder10.5SLC6A4
13seasonal affective disorder10.5SLC6A4
14constipation10.5SLC6A4
15substance abuse10.4SLC6A4
16landau-kleffner syndrome10.4
17colitis10.4
18speech and communication disorders10.4MECP2, FOXP2
19metachromatic leukodystrophy10.4ARSA
20childhood disintegrative disease10.3
21anxiety disorder10.3
22pandas10.3
23epsilon-trimethyllysine hydroxylase deficiency10.3
24autism susceptibility 1610.3
25autism susceptibility 1510.3
26autism susceptibility 1710.3
27autism 1810.3
28autism susceptibility, x-linked 210.3
29autism susceptibility, x-linked 110.3
30autism susceptibility, x-linked 310.3
31autism x-linked 510.3
32blindness10.3
33developmental disabilities10.3SCT, MECP2, FOXP2
34intellectual disability multi-gene panels10.3MECP2, NLGN4X, TMEM185A
35premature ovarian failure10.2PRL, FOXP2
36diabetes mellitus10.2
37bruxism10.2
38angelman syndrome10.2
39conduct disorder10.2
40tuberous sclerosis10.2
41pancreatic agenesis10.2
42neonatal diabetes mellitus10.2
43obsessive-compulsive disorder10.2
44measles10.2
45anorexia nervosa10.2
46frontal lobe epilepsy10.2
47cerebritis10.2
48aphasia10.2
49apraxia10.2
50influenza10.2

Graphical network of the top 20 diseases related to Pervasive Developmental Disorder:



Diseases related to pervasive developmental disorder

Symptoms for Pervasive Developmental Disorder

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Drugs & Therapeutics for Pervasive Developmental Disorder

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Drug clinical trials:

Search ClinicalTrials for Pervasive Developmental Disorder

Search NIH Clinical Center for Pervasive Developmental Disorder

Genetic Tests for Pervasive Developmental Disorder

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Anatomical Context for Pervasive Developmental Disorder

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MalaCards organs/tissues related to Pervasive Developmental Disorder:

32
Brain, Testes, Eye, Cortex, Heart, Skin, Prefrontal cortex

Animal Models for Pervasive Developmental Disorder or affiliated genes

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MGI Mouse Phenotypes related to Pervasive Developmental Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053829.4SLC6A4, MECP2, FOXP2, TBX1, GABRB3
2MP:00053778.8ABCB1, MECP2, FOXP2, TBX1, GABRB3, ARSA
3MP:00030128.5GABRB3, NLGN3, FOXP2, MECP2, SHANK2, ABCB1
4MP:00053767.6SCT, PRL, MECP2, FOXP2, TBX1, TDO2
5MP:00053867.1GABRB3, SCT, PRL, MECP2, FOXP2, NLGN3
6MP:00036317.1ARSA, SCT, PRL, MECP2, FOXP2, TBX1

Publications for Pervasive Developmental Disorder

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Articles related to Pervasive Developmental Disorder:

(show top 50)    (show all 252)
idTitleAuthorsYear
1
Catatonic features in adolescents with schizophrenia with and without a comorbid pervasive developmental disorder. (24914405)
2014
2
Sunsetting DSM-IV's pervasive developmental disorder. (24745948)
2014
3
Psychiatric comorbidity in children with high-functioning pervasive developmental disorder. (25272562)
2014
4
Yokukansan (TJ-54) for irritability associated with pervasive developmental disorder in children and adolescents: a 12-week prospective, open-label study. (23782127)
2013
5
Pervasive developmental disorder in the children of immigrant parents: comparison of different assessment instruments. (24394875)
2013
6
Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified. (24130822)
2013
7
Sexual obsessions, compulsions, suicidality and homicidality in an adolescent diagnosed with bipolar disorder not otherwise specified, obsessive-compulsive disorder, pervasive developmental disorder not otherwise specified, and mild mental retardation. (22612525)
2012
8
Novel AGTR2 missense mutation in a Japanese boy with severe mental retardation, pervasive developmental disorder, and epilepsy. (22269148)
2012
9
Application of DSM-5 criteria for autism spectrum disorder to three samples of children with DSM-IV diagnoses of pervasive developmental disorders. (23032385)
2012
10
Buspirone for bruxism in a child with pervasive developmental disorder-not otherwise specified. (22136097)
2011
11
Epilepsy in pervasive developmental disorder without brain MRI abnormalities. (20863637)
2011
12
Possible evidence for a fall in the prevalence of high-functioning pervasive developmental disorder with age? (22937245)
2011
13
Analysis of Copper and Zinc Plasma Concentration and the Efficacy of Zinc Therapy in Individuals with Asperger's Syndrome, Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) and Autism. (22174567)
2011
14
Aripiprazole improves social interaction in Taiwanese children with pervasive developmental disorder. (20438675)
2010
15
Pervasive developmental disorder behavior in adolescents with intellectual disability and co-occurring somatic chronic diseases. (19948390)
2010
16
Retraction--Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. (20137807)
2010
17
Clinical features of epilepsy with pervasive developmental disorder. (20708864)
2010
18
An open-label trial of topiramate in the treatment of skin picking in pervasive developmental disorder not otherwise specified. (20694122)
2010
19
Targeting social skills deficits in an adolescent with pervasive developmental disorder. (20514202)
2009
20
Pathways to psychosis: a comparison of the pervasive developmental disorder subtype Multiple Complex Developmental Disorder and the "At Risk Mental State". (18055179)
2008
21
Editorial review: Shifting views on juvenile bipolar disorder and pervasive developmental disorder. (18520735)
2008
22
Injury treatment among children with autism or pervasive developmental disorder. (17690968)
2008
23
Cognitive profile difference between normally intelligent children with Asperger's disorder and those with pervasive developmental disorder not otherwise specified. (19068006)
2008
24
Abnormal spatial frequency processing in high-functioning children with pervasive developmental disorder (PDD). (17591458)
2007
25
Visual completion and complexity of visual shape in children with pervasive developmental disorder. (17136302)
2007
26
Epilepsy in patients with pervasive developmental disorder not otherwise specified. (17940246)
2007
27
Integrity of lateral and feedbackward connections in visual processing in children with pervasive developmental disorder. (17101159)
2007
28
Effects of object complexity and type on the gaze behavior of children with pervasive developmental disorder. (17628272)
2007
29
Electrocortical reflections of face and gaze processing in children with pervasive developmental disorder. (17073985)
2006
30
The metaphor and sarcasm scenario test: a new instrument to help differentiate high functioning pervasive developmental disorder from attention deficit/hyperactivity disorder. (15165670)
2004
31
Pseudologia Fantastica associated with Pervasive Developmental Disorder. (12108140)
2002
32
Prolactin levels in young children with pervasive developmental disorders during risperidone treatment. (11838821)
2001
33
Impact of music therapy on the communication skills of toddlers with pervasive developmental disorder. (11458864)
2001
34
Olanzapine use in subjects with pervasive developmental disorder displaying aggression and/or self-mutilation. (15990518)
2001
35
Parent-directed, intensive early intervention for children with pervasive developmental disorder. (10983784)
2000
36
The classification of autism, Asperger's syndrome, and pervasive developmental disorder. (11086556)
2000
37
How unspecified are disorders of children with a pervasive developmental disorder not otherwise specified? A study of social problems in children with PDD-NOS and ADHD. (11095039)
2000
38
Children with PDD need to be evaluated by clinical geneticists. Pervasive developmental disorder. (10071950)
1999
39
Familial factors influence level of functioning in pervasive developmental disorder. (10361794)
1999
40
Lack of benefit of a single dose of synthetic human secretin in the treatment of autism and pervasive developmental disorder. (10588965)
1999
41
Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. (9500320)
1998
42
Outcomes of genetic evaluation in children with pervasive developmental disorder. (9809261)
1998
43
Emotional role-taking abilities of children with a pervasive developmental disorder not otherwise specified. (7782410)
1995
44
The pervasive developmental disorder spectrum: a case illustration. (8443614)
1993
45
Subclassification of children with autism and pervasive developmental disorder: a questionnaire based on Wing's subgrouping scheme. (8331045)
1993
46
Treatment strategies for a case of concurrent pervasive developmental disorder and cerebral gigantism. (2055890)
1991
47
Acquired aphasia with convulsive disorder: a pervasive developmental disorder variant. (1700988)
1990
48
Low-dose neuroleptic therapy for children with childhood-onset pervasive developmental disorder. (3344846)
1988
49
Tourette syndrome, atypical pervasive developmental disorder and Ganser syndrome in a 15-year-old, visually impaired, mentally retarded boy. (3855681)
1985
50
Age of recognition of pervasive developmental disorder. (4073310)
1985

Variations for Pervasive Developmental Disorder

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Expression for genes affiliated with Pervasive Developmental Disorder

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Expression patterns in normal tissues for genes affiliated with Pervasive Developmental Disorder

Search GEO for disease gene expression data for Pervasive Developmental Disorder.

Pathways for genes affiliated with Pervasive Developmental Disorder

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Compounds for genes affiliated with Pervasive Developmental Disorder

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Compounds related to Pervasive Developmental Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1m-chlorophenylpiperazine4410.3SLC6A4, PRL
2mcpp4410.3SLC6A4, PRL
3pindolol44 28 1112.3SLC6A4, PRL
4mdma4410.3SLC6A4, PRL
5amoxapine28 44 1112.2SLC6A4, PRL
6mhpg4410.2PRL, SLC6A4
75-hydroxytryptophan4410.2PRL, SLC6A4
8protriptyline50 1111.2SLC6A4, ABCB1
9ivermectin44 1111.1ABCB1, GABRB3
10reboxetine44 28 1112.1SLC6A4, ABCB1
11sodium bicarbonate44 1111.1SLC6A4, SCT
12amantadine44 1111.1ABCB1, SCT
13gaba4410.1SLC6A4, GABRB3, MECP2, SCT
14trazodone44 28 1112.1ABCB1, SLC6A4
15maprotiline44 50 1112.1ABCB1, SLC6A4
16mirtazapine44 50 1112.1PRL, SLC6A4
17homovanillic acid44 2411.0PRL, SLC6A4
18dextromethorphan2 50 24 1113.0ABCB1, SLC6A4
19nefazodone44 50 1112.0ABCB1, SLC6A4
20fenfluramine44 28 1112.0PRL, SLC6A4
21flupenthixol44 50 1112.0PRL, ABCB1
22fluphenazine28 44 50 1112.9ABCB1, PRL
235-hydroxytryptamine449.9PRL, TDO2, SLC6A4
24domperidone44 28 1111.9ABCB1, PRL
25buspirone44 28 1111.8PRL, SCT, ABCB1
26pimozide28 44 50 1112.8PRL, ABCB1
27naltrexone44 28 50 1112.8PRL, SCT, ABCB1
28trimipramine44 50 1111.8ABCB1, PRL, SLC6A4
29clomipramine44 50 1111.8SLC6A4, PRL, ABCB1
30paroxetine44 50 28 1112.8ABCB1, PRL, SLC6A4
31quetiapine44 50 28 24 1113.8SLC6A4, PRL, ABCB1
32citalopram44 50 24 1112.8ABCB1, PRL, SLC6A4
33paliperidone44 1110.8ABCB1, PRL
34olanzapine44 50 28 24 1113.8SLC6A4, PRL, ABCB1
35nitrazepam44 1110.8GABRB3, ABCB1
36clozapine44 28 50 1112.8SLC6A4, PRL, ABCB1
37haloperidol44 50 28 2 1113.7ABCB1, PRL, SLC6A4
38estrone44 28 24 1112.7ARSA, PRL, ABCB1
39sertraline44 28 50 24 1113.6ABCB1, SLC6A4
40risperidone44 50 28 61 24 1114.6SLC6A4, PRL, SCT, ABCB1
41fluoxetine44 50 28 1112.6ABCB1, SCT, PRL, SLC6A4
42clonidine44 50 28 1112.6ABCB1, SCT, PRL, SLC6A4
43arginine449.6SLC6A4, TDO2, MECP2, PRL, SCT
44epinephrine44 24 1111.6ABCB1, SCT, PRL, SLC6A4
45dihydrotestosterone44 28 24 1112.6ABCB1, PRL, SLC6A4
46toremifene44 1110.6ABCB1, PRL
47alanine449.6MECP2, FOXP2, TDO2, SLC6A4, ARSA
48glutamate449.5SHANK2, SCT, MECP2, FOXP2, SLC6A4
49fluvoxamine44 50 1111.4SLC6A4, ABCB1
50testosterone44 61 24 1112.4ABCB1, SCT, PRL, MECP2, SLC6A4

GO Terms for genes affiliated with Pervasive Developmental Disorder

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Cellular components related to Pervasive Developmental Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1excitatory synapseGO:0600769.9NLGN4X, NLGN3
2postsynaptic membraneGO:0452119.7GABRB3, NLGN4X, SHANK2
3cell junctionGO:0300549.1GABRB3, NLGN4X, NLGN3, SHANK2

Biological processes related to Pervasive Developmental Disorder according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1presynaptic membrane assemblyGO:09710510.2NLGN4X, NLGN3
2regulation of respiratory gaseous exchange by neurological system processGO:00208710.1MECP2, NLGN3
3cerebellum developmentGO:02154910.1FOXP2, MECP2, NLGN4X
4neuron cell-cell adhesionGO:00715810.1NLGN4X, NLGN3
5visual learningGO:00854210.1MECP2, NLGN3, SCT
6positive regulation of mesenchymal cell proliferationGO:00205310.0TBX1, FOXP2
7negative regulation of neuron apoptotic processGO:04352410.0MECP2, SCT, GABRB3
8positive regulation of synapse assemblyGO:0519659.9MECP2, NLGN3
9long-term synaptic potentiationGO:0602919.9SHANK2, MECP2
10vocalization behaviorGO:0716259.9NLGN3, NLGN4X, SHANK2
11adult behaviorGO:0305349.8SHANK2, NLGN3, NLGN4X
12learningGO:0076129.8NLGN3, SHANK2, NLGN4X
13synapse assemblyGO:0074169.8NLGN3, MECP2, SHANK2
14synapse organizationGO:0508089.7NLGN3, NLGN4X
15social behaviorGO:0351769.2NLGN3, SHANK2, TBX1, MECP2, SLC6A4, NLGN4X

Molecular functions related to Pervasive Developmental Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neurexin family protein bindingGO:04204310.0NLGN4X, NLGN3

Products for genes affiliated with Pervasive Developmental Disorder

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Sources for Pervasive Developmental Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet