MCID: PRV006
MIFTS: 48

Pervasive Developmental Disorder malady

Neuronal diseases category

Summaries for Pervasive Developmental Disorder

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8Disease Ontology, 43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 The diagnostic category of pervasive developmental disorders (PDD) refers to a group of disorders characterized by delays in the development of socialization and communication skills. Parents may note symptoms as early as infancy, although the typical age of onset is before 3 years of age. Symptoms may include problems with using and understanding language; difficulty relating to people, objects, and events; unusual play with toys and other objects; difficulty with changes in routine or familiar surroundings, and repetitive body movements or behavior patterns. Autism (a developmental brain disorder characterized by impaired social interaction and communication skills, and a limited range of activities and interests) is the most characteristic and best studied PDD. Other types of PDD include Asperger's Syndrome, Childhood Disintegrative Disorder, and Rett's Syndrome. Children with PDD vary widely in abilities, intelligence, and behaviors. Some children do not speak at all, others speak in limited phrases or conversations, and some have relatively normal language development. Repetitive play skills and limited social skills are generally evident. Unusual responses to sensory information, such as loud noises and lights, are also common.

MalaCards: Pervasive Developmental Disorder, also known as pervasive development disorder, is related to attention deficit hyperactivity disorder and autistic disorder. An important gene associated with Pervasive Developmental Disorder is SCT (secretin), and among its related pathways is GABA A receptor activation. The compounds protriptyline and Zimelidine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and skin, and related mouse phenotypes are no phenotypic analysis and hearing/vestibular/ear.

Disease Ontology:8 A developmental disorder of mental health that refers to a group of five disorders characterized by impairments in socialization and communication, as well as restricted interests and repetitive behaviors.

Wikipedia:63 The diagnostic category pervasive developmental disorders (PDD), as opposed to specific developmental... more...

Aliases & Classifications for Pervasive Developmental Disorder

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Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 43NINDS, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

pervasive developmental disorder 8 44
pervasive development disorder 8 60
pervasive developmental disorders 43


External Ids:

Disease Ontology8 DOID:0060040
ICD9CM27 299.80
ICD1025 F84

Related Diseases for Pervasive Developmental Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pervasive Developmental Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1attention deficit hyperactivity disorder31.1SLC6A4
2autistic disorder31.1NLGN4X, NLGN3, FOXP2, SCT, GABRB3, MECP2
3bipolar disorder30.6SLC6A4, TBX1
4atypical autism30.6NLGN4X, NLGN3, GABRB3, TMEM185A
5rett syndrome30.5GABRB3, MECP2
6developmental disabilities30.5MECP2, SCT, FOXP2
7intellectual disability30.4TMEM185A, MECP2, NLGN4X
8schizophrenia30.4FOXP2, SCT, ARSA, MECP2, PRL, TBX1
9anorexia nervosa30.2SLC6A4, PRL
10asperger syndrome30.2NLGN4X, NLGN3, MECP2, SLC6A4
11psychotic disorder30.2ARSA, PRL, SLC6A4
12fragile x syndrome30.2MECP2, FRAXE, FRAXA, SLC6A4, TMEM185A
13specific developmental disorder10.5
14autism spectrum disorder10.5
15anxiety disorder10.4
16tic disorder10.4
17pervasive developmental disorder not otherwise specified10.4
18landau-kleffner syndrome10.4
19personality disorder10.4
20sleep disorder10.4
21schizophreniform disorder10.3
22reading disorder10.3
23speech disorder10.3
24epsilon-trimethyllysine hydroxylase deficiency10.3
25autism susceptibility 1610.3
26autism susceptibility 1510.3
27autism susceptibility 1710.3
28autism 1810.3
29autism susceptibility, x-linked 210.3
30autism susceptibility, x-linked 110.3
31autism susceptibility, x-linked 310.3
32autism x-linked 510.3
33bruxism10.1
34conversion disorder10.1
35angelman syndrome10.1
36tuberous sclerosis10.1
37frontal lobe epilepsy10.1
38childhood disintegrative disease10.1
39cerebritis10.1
40somatization disorder10.1
41obsessive-compulsive disorder10.1
42adjustment disorder10.1
43pain disorder10.1
44conduct disorder10.1
45neonatal diabetes mellitus10.1
46developmental coordination disorder10.1
47measles10.1
48aphasia10.1
49apraxia10.1
50diabetes mellitus10.1

Graphical network of the top 20 diseases related to Pervasive Developmental Disorder:



Diseases related to pervasive developmental disorder

Clinical Features for Pervasive Developmental Disorder

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Drugs & Therapeutics for Pervasive Developmental Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pervasive Developmental Disorder

Drug clinical trials:

Search ClinicalTrials for Pervasive Developmental Disorder

Search NIH Clinical Center for Pervasive Developmental Disorder

Search CenterWatch for Pervasive Developmental Disorder

Genetic Tests for Pervasive Developmental Disorder

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Anatomical Context for Pervasive Developmental Disorder

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Sources:
32MalaCards
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MalaCards organs/tissues related to Pervasive Developmental Disorder:

32
Brain, Testes, Skin, Eye, Heart, Cortex, Prefrontal cortex

Animal Models for Pervasive Developmental Disorder or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Pervasive Developmental Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.8NLGN3, FOXP2, MECP2, SHANK2, ABCB1, GABRB3
2MP:00053778.6GABRB3, ARSA, MECP2, TBX1, ABCB1, FOXP2
3MP:00053867.0TDO2, NLGN3, FOXP2, SCT, GABRB3, ARSA
4MP:00036316.9ARSA, GABRB3, SCT, FOXP2, NLGN3, MECP2

Publications for Pervasive Developmental Disorder

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50PubMed
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Articles related to Pervasive Developmental Disorder:

(show top 50)    (show all 247)
idTitleAuthorsYear
1
Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified. (24130822)
2013
2
Reduced brain activation during imitation and observation of others in children with pervasive developmental disorder: a pilot study. (23718943)
2013
3
Sexual obsessions, compulsions, suicidality and homicidality in an adolescent diagnosed with bipolar disorder not otherwise specified, obsessive-compulsive disorder, pervasive developmental disorder not otherwise specified, and mild mental retardation. (22612525)
2012
4
Using virtual reality environment to improve joint attention associated with pervasive developmental disorder. (22776822)
2012
5
A case of autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) coexisting with pervasive developmental disorder harboring SCN1A mutation in addition to CHRNB2 mutation. (23032131)
2012
6
Retrospective case report: evaluation of pain in a child with pervasive developmental disorder. (21552087)
2011
7
New onset of psychotic symptoms in an adolescent with pervasive developmental disorder, not otherwise specified. (21309699)
2011
8
Aripiprazole improves social interaction in Taiwanese children with pervasive developmental disorder. (20438675)
2010
9
An open-label trial of topiramate in the treatment of skin picking in pervasive developmental disorder not otherwise specified. (20694122)
2010
10
Lorazepam, fluoxetine and packing therapy in an adolescent with pervasive developmental disorder and catatonia. (20888413)
2010
11
Exploring a cognitive intervention for children with pervasive developmental disorder. (19341019)
2009
12
Stereotypies and repetitive/restrictive behaviours in infants with autism and pervasive developmental disorder. (19466619)
2009
13
Pathways to psychosis: a comparison of the pervasive developmental disorder subtype Multiple Complex Developmental Disorder and the "At Risk Mental State". (18055179)
2008
14
Successful olanzapine treatment of anorexia nervosa in a girl with pervasive developmental disorder not otherwise specified. (19068020)
2008
15
Epilepsy in patients with pervasive developmental disorder not otherwise specified. (17940246)
2007
16
Effects of object complexity and type on the gaze behavior of children with pervasive developmental disorder. (17628272)
2007
17
Retrospective evaluation of an intensive method of treatment for children with pervasive developmental disorder. (17942455)
2007
18
Mood and anxiety symptoms in an adolescent with Pervasive Developmental Disorder Not Otherwise Specified and moderate mental retardation. (17979592)
2007
19
Chain reaction or time bomb: a neuropsychiatric-developmental/neurodevelopmental formulation of tourettisms, pervasive developmental disorder, and schizophreniform symptomatology associated with PANDAS. (17654411)
2007
20
A double-blind placebo-controlled pilot study of olanzapine in childhood/adolescent pervasive developmental disorder. (17069543)
2006
21
Donepezil in the treatment of ADHD-like symptoms in youths with pervasive developmental disorder: a case series. (16481671)
2006
22
The diagnostic utility of a genetics evaluation in children with pervasive developmental disorders. (16418599)
2006
23
Clinical significance of tics and attention-deficit hyperactivity disorder (ADHD) in children with pervasive developmental disorder. (15996396)
2005
24
A girl with pervasive developmental disorder and complex chromosome rearrangement involving 8p and 10p. (16119480)
2005
25
Risperidone-induced prolactin elevation in a prospective study of children, adolescents, and adults with mental retardation and pervasive developmental disorders. (16379508)
2005
26
The metaphor and sarcasm scenario test: a new instrument to help differentiate high functioning pervasive developmental disorder from attention deficit/hyperactivity disorder. (15165670)
2004
27
Pharmacotherapy of pervasive developmental disorders in children and adolescents. (15584771)
2004
28
Efficacy of porcine secretin in children with autism and pervasive developmental disorder. (12108616)
2002
29
Autistic disorder versus other pervasive developmental disorders in young children: same or different? (11315538)
2001
30
The classification of autism, Asperger's syndrome, and pervasive developmental disorder. (11086556)
2000
31
The pharmacotherapy of target symptoms associated with autistic disorder and other pervasive developmental disorders. (10902094)
2000
32
Review of adaptive behavior studies in mentally retarded persons with autism/pervasive developmental disorder. (10819119)
2000
33
Exploring the boundaries of pervasive developmental disorder not otherwise specified: analyses of data from the DSM-IV Autistic Disorder Field Trial. (10097993)
1999
34
Beneficial effects of clonidine on severe self-injurious behavior in a 9-year-old girl with pervasive developmental disorder. (10630459)
1999
35
A comparison of social skills in adults with autistic disorder, pervasive developmental disorder not otherwise specified, and mental retardation. (10478728)
1999
36
Aggressive behavior in patients with attention-deficit/hyperactivity disorder, conduct disorder, and pervasive developmental disorders. (10418807)
1999
37
Outcomes of genetic evaluation in children with pervasive developmental disorder. (9809261)
1998
38
Brief report: interpretation of facial expressions, postures and gestures in children with a pervasive developmental disorder not otherwise specified. (9656138)
1998
39
Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. (9683237)
1998
40
Brief report: autistic behaviors among children with fragile X or Rett syndrome: implications for the classification of pervasive developmental disorder. (9711488)
1998
41
Mania in children with pervasive developmental disorder revisited. (9394940)
1997
42
Nonverbal learning disabilities, Asperger's syndrome, pervasive developmental disorder--should we care? (9120217)
1996
43
Emotional role-taking abilities of children with a pervasive developmental disorder not otherwise specified. (7782410)
1995
44
Case study: corticosteroid treatment of language regression in pervasive developmental disorder. (7545148)
1995
45
An outpatient treatment program for young children with pervasive developmental disorder. (7762697)
1995
46
Is development of Tourette disorder a marker for improvement in patients with autism and other pervasive developmental disorders? (3473062)
1987
47
Differentiation of infantile autistic, child-onset pervasive developmental disorder, and mentally retarded children, with the Personality Inventory for Children. (3429401)
1987
48
Age of recognition of pervasive developmental disorder. (4073310)
1985
49
Use of stimulant medication in treating pervasive developmental disorder. (7258372)
1981
50
Coexistence of childhood onset pervasive developmental disorder and attention deficit disorder with hyperactivity. (7468843)
1981

Genetic Variations for Pervasive Developmental Disorder

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Expression for genes affiliated with Pervasive Developmental Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pervasive Developmental Disorder

Search GEO for disease gene expression data for Pervasive Developmental Disorder.

Pathways for genes affiliated with Pervasive Developmental Disorder

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Sources:
53Reactome, 12EMD Millipore, 52R&D Systems
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Pathways related to Pervasive Developmental Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8GABRB3, NLGN3, NLGN4X

Compounds for genes affiliated with Pervasive Developmental Disorder

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Sources:
49PharmGKB, 11DrugBank, 44Novoseek, 28IUPHAR, 2BitterDB, 24HMDB, 59Tocris Bioscience
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Compounds related to Pervasive Developmental Disorder according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1protriptyline49 1111.3SLC6A4, ABCB1
2Zimelidine1110.3SLC6A4, ABCB1
3Levomilnacipran1110.3ABCB1, SLC6A4
4reboxetine44 28 1112.3SLC6A4, ABCB1
5ivermectin44 1111.3GABRB3, ABCB1
6trazodone44 28 1112.2SLC6A4, ABCB1
7amantadine44 1111.2SCT, ABCB1
8dextromethorphan2 49 11 2413.2ABCB1, SLC6A4
9maprotiline44 1111.2ABCB1, SLC6A4
10citalopram49 44 11 2413.1SLC6A4, PRL
11m-chlorophenylpiperazine4410.1PRL, SLC6A4
12mcpp4410.1SLC6A4, PRL
13pindolol44 28 1112.1SLC6A4, PRL
14nefazodone44 49 1112.1ABCB1, SLC6A4
15amoxapine44 28 1112.1PRL, SLC6A4
16mdma4410.1PRL, SLC6A4
17sodium bicarbonate44 1111.1SLC6A4, SCT
18gaba4410.1SLC6A4, MECP2, GABRB3, SCT
19mhpg4410.0PRL, SLC6A4
205-hydroxytryptophan4410.0PRL, SLC6A4
21flupenthixol44 49 1111.9ABCB1, PRL
22fluphenazine28 44 1111.9ABCB1, PRL
23sertraline44 28 49 11 2413.9ABCB1, SLC6A4
24mirtazapine49 44 1111.8PRL, SLC6A4
25buspirone44 28 1111.8SCT, PRL, ABCB1
26naltrexone44 49 28 1112.8SCT, PRL, ABCB1
27trimipramine49 44 1111.8SLC6A4, ABCB1, PRL
28clomipramine44 49 1111.8PRL, ABCB1, SLC6A4
29paroxetine44 49 28 1112.8PRL, ABCB1, SLC6A4
30domperidone44 28 1111.8ABCB1, PRL
31pimozide28 49 44 1112.7PRL, ABCB1
32clozapine44 28 49 1112.7SLC6A4, ABCB1, PRL
33haloperidol44 28 2 49 1113.7SLC6A4, ABCB1, PRL
34paliperidone44 1110.6PRL, ABCB1
35homovanillic acid44 2410.6PRL, SLC6A4
36risperidone28 44 49 59 11 2414.6SLC6A4, ABCB1, PRL, SCT
37estrone44 28 11 2412.6ARSA, PRL, ABCB1
38fluoxetine49 44 28 1112.6SCT, PRL, ABCB1, SLC6A4
39clonidine44 28 1111.6SLC6A4, ABCB1, PRL, SCT
40epinephrine44 11 2411.5SCT, PRL, ABCB1, SLC6A4
41fenfluramine28 44 1111.4PRL, SLC6A4
42testosterone44 59 11 2412.3SCT, MECP2, PRL, ABCB1, SLC6A4

GO Terms for genes affiliated with Pervasive Developmental Disorder

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16Gene Ontology
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Cellular components related to Pervasive Developmental Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1excitatory synapseGO:0600769.7NLGN3, NLGN4X
2cell junctionGO:0300549.4SHANK2, GABRB3, NLGN3, NLGN4X

Biological processes related to Pervasive Developmental Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of synapse assemblyGO:05196510.0MECP2, NLGN3
2cerebellum developmentGO:0215499.9MECP2, FOXP2, NLGN4X
3presynaptic membrane assemblyGO:0971059.9NLGN3, NLGN4X
4visual learningGO:0085429.8NLGN3, SCT, MECP2
5regulation of respiratory gaseous exchange by neurological system processGO:0020879.7MECP2, NLGN3
6social behaviorGO:0351769.4SLC6A4, TBX1, MECP2, NLGN3, NLGN4X

Molecular functions related to Pervasive Developmental Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neurexin family protein bindingGO:04204310.0NLGN3, NLGN4X

Products for genes affiliated with Pervasive Developmental Disorder

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Pervasive Developmental Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet