Peyronie's Disease malady

NIH Rare Diseases: Peyronie disease is a rare connective tissue disorder characterized by a plaque, or hard lump, that forms within the penis. Affected individuals may experience painful, curved erections which can make make normal sexual intercourse impossible. Symptoms may appear suddenly or develop gradually. While the painful erections for most men resolve over time, the scar tissue and curvature may remain. Some cases appear to resolve spontaneously. The exact cause of Peyronie's disease is not known.³⁰

MalaCards: Peyronie's Disease, also known as peyronie disease, is related to blindness and peyronies disease. An important gene associated with Peyronie's Disease is IFNA2 (interferon, alpha 2), and among its related pathways are Chagas disease (American trypanosomiasis) and TGF-beta signaling pathway. The compounds diphenyliodonium and vardenafil have been mentioned in the context of this disorder. Affiliated tissues include monocytes and b cells, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Wikipedia: Peyronie\'s Disease (also known as \"Induratio penis plastica\", or more recently Chronic Inflammation...⁴⁴ more...

Aliases & Descriptions:

peyronie's disease 6 peyronie disease 6 30 32 43 induratio penis plastica (disorder) 6 balanitis xerotica obliterans 43

induratio penis plastica 6 peyronie's fibromatosis 6 penile curvature 30

Diseases related to peyronie's disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 409)

id	Related Disease	Score	Top Affiliating Genes
1	blindness	27.6	PDE4A, CD36, CCL2, IFNA2, HLA-B, PDE5A
2	peyronies disease	26.7	PDE4A, SEPT3, SERPINA1, BMP6, MSTN, CD36
3	fibrosis	21.5	PDE4A, SERPINA1, BMP6, MSTN, CD36, CCL2
4	retinal vasculitis	13.6	IFNA2, NOS2, SOD1
5	low compliance bladder	13.4	PDE4A, PDE5A
6	diffuse scleroderma	13.4	BMP6, TGFB1
7	priapism	13.4	PDE4A, NOS2, PDE5A
8	hereditary hemorrhagic telangiectasia	13.3	BMP6, TGFB1
9	diabetic polyneuropathy	13.3	BMP6, NOS2, SOD1
10	cystic fibrosis lung disease	13.3	SERPINA1, NOS2, TGFB1
11	dyspepsia	13.2	PDE4A, SEPT3, NOS2, PDE5A
12	serous glue ear	13.2	BMP6, NOS2, TGFB1, SOD1
13	obstructive lung disease	13.1	PDE4A, SERPINA1, TGFB1
14	hepatocellular cancer	13.1	BMP6, TGFB1, SOD1
15	chronic obstructive pulmonary disease	13.1	SERPINA1, HMOX1
16	idiopathic interstitial pneumonia	13.1	CCL2, TGFB1, POSTN
17	anthracosis	13.1	BMP6, CCL2, SOD1
18	retinal detachment	13.1	CCL2, NOS2, TGFB1, SOD1
19	angiofibroma	13.1	BMP6, NOS2, DCN
20	pulmonary hypertension	13.1	PDE4A, NOS2, PDE5A
21	bronchitis	13.1	PDE4A, MSTN, PDE5A
22	paralysis	13.1	PDE4A, IFNA2, TGFB1, SOD1
23	proliferative diabetic retinopathy	13.1	CCL2, IFNA2, TGFB1, SOD1
24	polyneuropathy	13.1	BMP6, IFNA2, NOS2, SOD1
25	otitis media	13.1	BMP6, NOS2, TGFB1, SOD1
26	vaginitis	13.0	IFNA2, PDE5A, TGFB1, DCN, SOD1
27	diabetic angiopathy	13.0	BMP6, CCL2, NOS2
28	proliferative vitreoretinopathy	13.0	BMP6, CCL2, TGFB1
29	pulmonary embolism	13.0	IFNA2, HLA-B, PDE5A, SOD1
30	prostate disease	13.0	SERPINA1, BMP6, TGFB1
31	interstitial lung disease	13.0	BMP6, CCL2, TGFB1
32	brucellosis	13.0	HLA-B, NOS2, TGFB1
33	varicocele	13.0	HMOX1, NOS2, SOD1
34	silicosis	13.0	HMOX1, NOS2, TGFB1, SOD1
35	end stage renal failure	13.0	HMOX1, NOS2, TGFB1, SOD1
36	postherpetic neuralgia	13.0	HLA-A, HLA-B
37	pleurisy	13.0	PDE4A, CCL2, TGFB1
38	nephrogenic systemic fibrosis	13.0	SMAD3, TGFB1, DCN
39	rheumatoid arthritis, association with	13.0	HLA-C, NOS2, TGFB1
40	pars planitis	12.9	HLA-A, HLA-B
41	myostatin-related muscle hypertrophy	12.9	BMP6, MSTN, PDE5A, TGFB1, TAGLN
42	pneumoconiosis	12.9	BMP6, CCL2, TGFB1, SOD1
43	cutaneous leishmaniasis	12.9	BMP6, CCL2, NOS2, SOD1
44	chorioamnionitis	12.9	BMP6, CCL2, TGFB1, SOD1
45	pulmonary sarcoidosis	12.9	CCL2, NOS2, TGFB1, DCN, SOD1
46	eosinophilia	12.9	PDE4A, SERPINA1, IFNA2, NOS2, TGFB1
47	hepatitis c	12.9	SERPINA1, IFNA2, HLA-A, TGFB1
48	migraine without aura	12.9	CCL2, NOS2, PDE5A, TGFB1, SOD1
49	biliary tract cancer	12.9	SERPINA1, BMP6, IFNA2, NOS2, TGFB1
50	cryoglobulinemia	12.8	BMP6, CCL2, IFNA2

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to peyronie's disease:

²²

MGI Mouse Phenotypes related to peyronie's disease:

²⁵ (show all 17)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	10.0	DCN, TAGLN, MSTN
2	hematopoietic system phenotype	MP:0005397	9.9	HLA-C, PTN
3	craniofacial phenotype	MP:0005382	9.3	POSTN, SMAD3, MSTN
4	liver/biliary system phenotype	MP:0005370	9.1	SOD1, SMAD3, PTN, CD36, MSTN
5	immune system phenotype	MP:0005387	9.1	PDE4A, POSTN, DCN, TAGLN, PTN, HLA-C
6	reproductive system phenotype	MP:0005389	9.1	POSTN, TAGLN, TGFB1, NOS2, SMAD3, CCL2
7	skeleton phenotype	MP:0005390	9.1	POSTN, DCN, SMAD3, MSTN, BMP6
8	tumorigenesis	MP:0002006	8.5	POSTN, DCN, TAGLN, TGFB1, NOS2, SMAD3
9	growth/size phenotype	MP:0005378	8.5	POSTN, DCN, TAGLN, SMAD3, CUL9, MSTN
10	digestive/alimentary phenotype	MP:0005381	8.2	DCN, TAGLN, TGFB1, NOS2, SMAD3, CCL2
11	nervous system phenotype	MP:0003631	8.0	PDE4A, SEPT3, CD36, HLA-C, PTN, SMAD3
12	behavior/neurological phenotype	MP:0005386	7.8	DCN, TAGLN, NOS2, SMAD3, PTN, HLA-C
13	muscle phenotype	MP:0005369	7.7	POSTN, SOD1, DCN, TAGLN, TGFB1, NOS2
14	cardiovascular system phenotype	MP:0005385	7.1	POSTN, SOD1, TAGLN, TGFB1, NOS2, SMAD3
15	homeostasis/metabolism phenotype	MP:0005376	6.7	NOS2, TGFB1, DCN, SOD1, POSTN, SMAD3
16	cellular phenotype	MP:0005384	6.6	NOS2, TGFB1, DCN, SOD1, POSTN, SMAD3
17	mortality/aging	MP:0010768	6.3	TGFB1, TAGLN, DCN, SOD1, POSTN, NOS2

Articles related to peyronie's disease:

(show all 35)

id	Title	Authors	Year	Affiliating Genes
1	Treatment of Peyronie's disease with PDE5 inhibitors: an antifibrotic strategy. (20212516)	Gonzalez-Cadavid N.F.... Rajfer J.	2010	NOS2
2	Upregulation of mRNA expression of MCP-1 by TGF-beta1 in fibroblast cells from Peyronie's disease. (18704440)	Szardening-Kirchner C.... Weidner W.	2009	TGFB1
3	Profibrotic role of myostatin in Peyronie's disease. (18422491)	Cantini L.P.... Gonzalez-Cadavid N.F.	2008	TGFB1, MSTN
4	Significant alterations of serum cytokine levels in patients with Peyronie's disease. (18778497)	Zimmermann R.P.... Stenzl A.	2008	TGFB1
5	Investigation of the antifibrotic effect of IFN-gamma on fibroblasts in a cell culture model of Peyronie's disease. (17630104)	Haag S.M.... Weidner W.	2008	TGFB1
6	A critical analysis of nonsurgical treatment of Peyronie's disease. (16698449)	Hauck E.W.... Weidner W.	2006	IFNA2
7	Single-blind, multicenter, placebo controlled, parallel study to assess the safety and efficacy of intralesional interferon alpha-2B for minimally invasive treatment for Peyronie's disease. (16753449)	Hellstrom W.J.... Pryor J.L.	2006	IFNA2
8	Effect of intralesional interferon-alpha 2b combined with oral vitamin E for treatment of early stage Peyronie's disease: a randomized and prospective study. (16581113)	Inal T.... Yaman O.	2006	IFNA2
9	Role of increased transforming growth factor beta protein expression in the pathogenesis of Peyronie's disease. (16734133)	Hassoba H.... Lue T.	2005	TGFB1, BMP6
10	Mechanisms of Disease: new insights into the cellular and molecular pathology of Peyronie's disease. (16474811)	Gonzalez-Cadavid N.F.... Rajfer J.	2005	DCN, NOS2
11	Evidence that osteogenic progenitor cells in the human tunica albuginea may originate from stem cells: implications for peyronie disease. (16093362)	Vernet D.... Gonzalez-Cadavid N.F.	2005	TGFB1, TAGLN, POSTN
12	The impact of intralesional interferon alpha-2b injection therapy on penile hemodynamics in men with Peyronie's disease. (16422829)	Kendirci M.... Hellstrom W.J.	2005	IFNA2
13	Alpha-1-antitrypsin levels and genetic variation of the alpha-1-antitrypsin gene in Peyronie's disease. (15474273)	Hauck E.W.... Hackstein H.	2004	SERPINA1
14	Intralesional interferon-alpha-2B injections for the treatment of Peyronie's disease. (14746421)	Dang G.... Hellstrom W.J.	2004	IFNA2
15	Expanding the paradigm for plaque development in Peyronie's disease. (14551585)	Mulhall J.P.	2003	NOS2
16	Prospective analysis of single nucleotide polymorphisms of the transforming growth factor beta-1 gene in Peyronie's disease. (12478192)	Hauck E.W.... Hackstein H.	2003	TGFB1
17	Prospective analysis of HLA classes I and II antigen frequency in patients with Peyronie's disease. (14501786)	Hauck E.W.... Hackstein H.	2003	HLA-A, HLA-C, HLA-B
18	Fibrin as an inducer of fibrosis in the tunica albuginea of the rat: a new animal model of Peyronie's disease. (12780843)	Davila H.H.... Gonzalez-Cadavid N.F.	2003	HMOX1, NOS2
19	Intralesional interferon-alpha-2b for the treatment of Peyronie's disease. (12454683)	Lacy G.L.... Hellstrom W.J.	2002	IFNA2
20	Implications of nitric oxide synthase isoforms in the pathophysiology of Peyronie's disease. (12454685)	Bivalacqua T.J.... Hellstrom W.J.	2002	NOS2
21	Gene expression profiles in the Peyronie's disease plaque. (11880101)	Magee T.R.... Gonzalez-Cadavid N.F.	2002	CCL2, PTN, ACTG2
22	Upregulation of monocyte chemoattractant protein 1 and effects of transforming growth factor-beta 1 in Peyronie's disease. (12127997)	Lin C.S.... Lue T.F.	2002	CCL2
23	Treatment of Peyronie's disease with local interferon-alpha 2b. (11350406)	Brake M.... Keller H.	2001	IFNA2
24	Combined intralesional interferon alpha 2B and oral vitamin E in the treatment of Peyronie's disease. (11519219)	Novak T.E.... Hellstrom W.J.	2001	IFNA2
25	Intralesional recombinant interferon alpha-2b in Peyronie's disease. (11037665)	Astorga R.... LA^pez-Saura P.	2000	IFNA2
26	A rat model of Peyronie's disease associated with a decrease in erectile activity and an increase in inducible nitric oxide synthase protein expression. (10799245)	Bivalacqua T.J.... Hellstrom W.J.	2000	TGFB1, NOS2
27	Stimulation of collagen production in an in vitro mod el for Peyronie's disease. (10467520)	Ahuja S.K.... Hellstrom W.J.	1999	CD36
28	A pilot study demonstrating clinical benefit from intralesional interferon alpha 2B in the treatment of Peyronie's disease. (10452584)	Ahuja S.... Hellstrom W.J.	1999	IFNA2
29	Peyronie's disease: intralesional treatment with interferon alpha-2A and evaluation of the results by magnetic resonance imaging. (9406006)	Polat O.... Bayraktar Y.	1997	IFNA2
30	Local interferon-alpha 2b is not an effective treatment in early-stage Peyronie's disease. (9286652)	Wegner H.E.... Miller K.	1997	IFNA2
31	Peyronie's disease is associated with an increase in transforming growth factor-beta protein expression. (9302128)	El-Sakka A.I.... Lue T.F.	1997	TGFB1, BMP6
32	Ultrasound and soft-tissue radiography to monitor local interferon-alpha 2B treatment in Peyronie's disease. (8845268)	Andresen R.... Miller K.	1996	IFNA2
33	Treatment of Peyronie's disease with local interferon-alpha 2b. (8536778)	Wegner H.E.... Miller K.	1995	IFNA2
34	Orgotein in the treatment of plastic induration of the penis (Peyronie's disease). (8365848)	Primus G.	1993	SOD1
35	La Peyronie's disease. Our experience (2186297)	Revelli G.... Drago G.W.	1990	SOD1

Genes related to peyronie's disease according to GeneCards:

(show all 25)

id	Symbol	Description	Score	GeneCards Section Context
1	IFNA2	interferon, alpha 2	11.0	Publications
2	PDE5A	phosphodiesterase 5A, cGMP-specific	11.0
3	TGFB1	transforming growth factor, beta 1	11.0	Publications
4	SOD1	superoxide dismutase 1, soluble	11.0	Publications
5	NOS2	nitric oxide synthase 2, inducible	11.0	Publications
6	HLA-S	major histocompatibility complex, class I, S (pseudogene)	11.0	Publications
7	SEPT3	septin 3	11.0	Disorders
8	TAGLN	transgelin	11.0	Publications
9	ACTG2	actin, gamma 2, smooth muscle, enteric	11.0	Publications
10	IPP	intracisternal A particle-promoted polypeptide	11.0
11	MSTN	myostatin	11.0	Publications
12	CUL9	cullin 9	11.0
13	POSTN	periostin, osteoblast specific factor	11.0	Publications
14	DCN	decorin	11.0	Publications
15	PTN	pleiotrophin	11.0	Publications
16	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	11.0	Publications
17	HLA-C	major histocompatibility complex, class I, C	11.0	Publications
18	PDE4A	phosphodiesterase 4A, cAMP-specific	11.0
19	HLA-A	major histocompatibility complex, class I, A	11.0	Publications
20	SMAD3	SMAD family member 3	11.0
21	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
22	BMP6	bone morphogenetic protein 6	11.0	Publications
23	HMOX1	heme oxygenase (decycling) 1	11.0	Publications
24	HLA-B	major histocompatibility complex, class I, B	11.0	Publications
25	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications

Pathways related to peyronie's disease according to GeneDecks:

(show all 15)

id	Pathway	Score	Top Affiliating Genes
1	Chagas disease (American trypanosomiasis)20	9.5	TGFB1, NOS2, SMAD3, CCL2
2	TGF-beta signaling pathway20	9.4	DCN, TGFB1, SMAD3, BMP6
3	Malaria20	9.3	TGFB1, CCL2, CD36
4	CTL Mediated Apoptosis36	9.2	HLA-A, HLA-B, HLA-C
5	Allograft rejection20	9.2	HLA-C, HLA-B, HLA-A
6	Graft-versus-host disease20	9.2	HLA-A, HLA-B, HLA-C
7	Type I diabetes mellitus20	9.1	HLA-A, HLA-B, HLA-C
8	Autoimmune thyroid disease20	9.1	IFNA2, HLA-A, HLA-B, HLA-C
9	Natural killer cell mediated cytotoxicity20	9.0	HLA-C, HLA-B, HLA-A, IFNA2
10	PAK Pathway36	9.0	TGFB1, ACTG2, PTN, CCL2, BMP6
11	Tec Kinases Signaling36	8.8	BMP6, CCL2, PTN, ACTG2, TGFB1
12	Endocytosis20	8.7	HLA-A, HLA-B, HLA-C, SMAD3, TGFB1
13	CDC42 Pathway36	8.6	HLA-A, HLA-B, HLA-C, ACTG2
14	JAK-STAT Pathway36	8.6	TGFB1, PTN, IFNA2, CCL2, BMP6
15	Phagosome20	8.5	CD36, HLA-A, HLA-B, HLA-C

Compounds related to peyronie's disease according to GeneDecks:

(show top 50)    (show all 104)

id	Compound	Score	Top Affiliating Genes
1	diphenyliodonium32	10.3	SOD1, TGFB1, NOS2
2	vardenafil32 9 9	12.1	PDE5A, PDE4A, NOS2
3	ascorbic acid32 18	11.1	IFNA2, CD36
4	onoo32	10.0	SERPINA1, SOD1, NOS2
5	sildenafil32 34 9 18 9	14.0	NOS2, PDE5A, TGFB1, PDE4A
6	h2o232	10.0	SERPINA1, PDE4A, PTN
7	deta nonoate32	9.9	HMOX1, NOS2
8	isoproterenol32 9 9	11.9	NOS2, PDE4A
9	ptio32	9.9	HMOX1, SOD1, NOS2
10	3-nitrotyrosine32	9.8	HMOX1, NOS2, SOD1
11	bleomycin32 9 9	11.8	CCL2, DCN, SMAD3
12	glycosaminoglycan32	9.7	DCN, PTN, CD36
13	ly29400232	9.7	CCL2, TGFB1, NOS2, SMAD3
14	diphenyleneiodonium32	9.6	SOD1, CCL2, TGFB1, NOS2
15	pirfenidone32	9.6	TGFB1, CD36, BMP6
16	pge232	9.5	DCN, PDE5A, HMOX1, PDE4A
17	betacarotene32	9.5	CD36, IFNA2, TGFB1, SOD1
18	ang ii32	9.4	TGFB1, NOS2, CCL2, CD36
19	sodium nitroprusside32	9.3	PDE5A, HMOX1, BMP6, PDE4A
20	pdtc32	9.3	CCL2, SOD1, TGFB1, HMOX1, NOS2
21	alpha lipoic acid32	9.2	NOS2, SERPINA1, CCL2, HMOX1, SOD1
22	hydroxyproline32 18	10.1	BMP6, DCN, TGFB1, CD36
23	dermatan sulfate32	9.1	DCN, CD36, BMP6, PTN
24	procollagen32	9.0	BMP6, SMAD3, TGFB1, DCN, CD36
25	oxygen32 18	9.9	SERPINA1, MSTN, DCN, PDE5A, HLA-B, NOS2
26	ursodeoxycholic acid32 9 18 9	11.9	IFNA2, BMP6, HLA-A, HLA-B
27	sb 20358032 42	9.8	CD36, BMP6, SMAD3, HMOX1
28	matrigel32	8.8	SMAD3, PTN, CD36, BMP6, DCN
29	superoxide32 18	9.6	HMOX1, PDE4A, IFNA2, CCL2, NOS2, TAGLN
30	indomethacin32 9 9	10.6	SOD1, TGFB1, BMP6, IFNA2, HMOX1, NOS2
31	15-deoxy-delta-12,14-prostaglandin j232	8.6	CD36, HMOX1, NOS2, BMP6, CCL2
32	acetylcholine32 9 18 9	11.5	TAGLN, PDE5A, NOS2, PDE4A, BMP6, HMOX1
33	prostacyclin32	8.4	CCL2, PDE5A, SOD1, PDE4A, BMP6, HMOX1
34	histamine32 18	9.4	CCL2, IFNA2, TGFB1, HMOX1, PDE5A, PDE4A
35	tgf beta132	8.4	SMAD3, CCL2, DCN, TAGLN, TGFB1, CD36
36	ribonucleic acid32	8.3	DCN, IFNA2, CCL2, MSTN, BMP6, HLA-B
37	estrogen32	8.2	POSTN, DCN, PDE5A, NOS2, SMAD3, HMOX1
38	polysaccharide32	8.1	HLA-B, PTN, DCN, CCL2, TGFB1, SERPINA1
39	pd 98,05932	8.0	DCN, TGFB1, CCL2, SMAD3, BMP6, PDE4A
40	zinc32 18	8.8	PDE4A, IFNA2, HLA-A, HLA-B, SMAD3, SOD1
41	creatinine32	7.6	CD36, CCL2, HLA-B, SERPINA1, TGFB1, SOD1
42	cycloheximide32	7.6	NOS2, CD36, BMP6, PDE4A, TGFB1, HMOX1
43	cyclosporin a32 42	8.6	BMP6, HMOX1, HLA-A, HLA-S, TGFB1, DCN
44	oligonucleotide32	7.6	TGFB1, PTN, HLA-B, SMAD3, DCN, HLA-A
45	arginine32	7.3	DCN, TAGLN, NOS2, HLA-B, HLA-A, PDE5A
46	retinoic acid32 42 18	8.8	IFNA2, CD36, BMP6, PDE4A, DCN, TAGLN
47	dexamethasone32 42 34 9 9	10.8	DCN, BMP6, CD36, CCL2, NOS2, TGFB1
48	vegf32	6.6	POSTN, TGFB1, DCN, PDE5A, NOS2, SMAD3
49	serine32	6.5	SEPT3, SERPINA1, BMP6, CD36, CCL2, HLA-B
50	nitric oxide32 9 18 9	9.4	CCL2, PDE4A, SERPINA1, BMP6, HLA-B, PTN

Cellular components related to peyronie's disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class I protein complex	GO:042612	9.0	HLA-C, HLA-B, HLA-A
2	ER to Golgi transport vesicle membrane	GO:012507	9.0	HLA-A, HLA-B, HLA-C
3	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	8.9	HLA-A, HLA-B, HLA-C
4	phagocytic vesicle membrane	GO:030670	8.7	HLA-C, HLA-B, HLA-A
5	extracellular space	GO:005615	7.4	SERPINA1, SOD1, DCN, TGFB1, PTN, HMOX1

Biological processes related to peyronie's disease according to GeneDecks:

(show all 20)

id	Name	GO ID	Score	Top Affiliating Genes
1	evasion or tolerance of host defenses by virus	GO:019049	10.2	SMAD3, TGFB1
2	regulation of striated muscle tissue development	GO:016202	10.0	TGFB1, SMAD3
3	regulation of binding	GO:051098	10.0	SMAD3, TGFB1
4	response to heat	GO:009408	9.7	MSTN, CCL2, SOD1
5	SMAD protein complex assembly	GO:007183	9.6	SMAD3, TGFB1
6	platelet degranulation	GO:002576	9.6	SOD1, TGFB1, CD36, SERPINA1
7	positive regulation of bone mineralization	GO:030501	9.6	TGFB1, SMAD3, BMP6
8	transforming growth factor beta receptor signaling pathway	GO:007179	9.4	MSTN, CCL2, SMAD3, TGFB1
9	low-density lipoprotein particle clearance	GO:034383	9.3	CD36, HMOX1
10	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	GO:002480	9.3	HLA-C, HLA-B, HLA-A
11	cellular response to lipopolysaccharide	GO:071222	9.2	CD36, CCL2, NOS2
12	response to hypoxia	GO:001666	9.1	SERPINA1, CCL2, SMAD3, NOS2, PDE5A, TGFB1
13	blood coagulation	GO:007596	9.1	SOD1, TGFB1, PDE5A, NOS2, IFNA2, CD36
14	type I interferon-mediated signaling pathway	GO:060337	9.1	HLA-C, HLA-B, HLA-A, IFNA2
15	regulation of immune response	GO:050776	8.8	SMAD3, HLA-C, HLA-B, HLA-A
16	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	GO:002479	8.7	CD36, HLA-A, HLA-B, HLA-C
17	antigen processing and presentation of exogenous peptide antigen via MHC class I	GO:042590	8.7	HLA-C, HLA-B, HLA-A, CD36
18	antigen processing and presentation of peptide antigen via MHC class I	GO:002474	8.7	HLA-C, HLA-B, HLA-A, CD36
19	cytokine-mediated signaling pathway	GO:019221	8.6	HLA-C, HLA-B, HLA-A, IFNA2, CCL2
20	immune response	GO:006955	8.0	SMAD3, HLA-C, HLA-B, HLA-A, BMP6

Molecular functions related to peyronie's disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	growth factor activity	GO:008083	9.3	BMP6, MSTN, PTN, TGFB1
2	heparin binding	GO:008201	9.2	MSTN, CCL2, PTN, POSTN
3	MHC class I receptor activity	GO:032393	9.0	HLA-A, HLA-B, HLA-C
4	receptor binding	GO:005102	8.1	NOS2, HLA-B, HLA-A, CCL2, MSTN