MCID: PYR010
MIFTS: 56

Peyronie's Disease malady

Reproductive diseases category

Summaries for Peyronie's Disease

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42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Peyronie disease is a rare connective tissue disorder characterized by a plaque, or hard lump, that forms within the penis. affected individuals may experience painful, curved erections which can make make normal sexual intercourse impossible. symptoms may appear suddenly or develop gradually. while the painful erections for most men resolve over time, the scar tissue and curvature may remain. some cases appear to resolve spontaneously. the exact cause of peyronie's disease is not known. last updated: 11/23/2011

MalaCards: Peyronie's Disease, also known as peyronie disease, is related to squamous cell carcinoma and peyronies disease. An important gene associated with Peyronie's Disease is IFNA2 (interferon, alpha 2), and among its related pathways are TGF-beta Signaling Pathway and NO-dependent CFTR activation (normal and CF). The compounds estrogen and indomethacin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, endothelial and bone, and related mouse phenotypes are skeleton and reproductive system.

Wikipedia:63 Peyronie\'s disease or Peyronie disease (/peɪroʊnˈiː/), also known as induratio penis plastica or... more...

Description from OMIM:46 171000

Aliases & Classifications for Peyronie's Disease

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8Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 60UMLS, 34MeSH, 46OMIM, 27ICD9CM, 39NCIt, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

peyronie's disease 8
peyronie disease 8 42 44 60
balanitis xerotica obliterans 60
induratio penis plastica 8
peyronie's fibromatosis 8
penile curvature 42


External Ids:

Disease Ontology8 DOID:8616
MeSH34 D010411
OMIM46 171000
ICD9CM27 607.85
NCIt39 C3316
ICD1025 N48.6

Related Diseases for Peyronie's Disease

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Peyronie's Disease:



Diseases related to peyronie's disease

Clinical Features for Peyronie's Disease

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46OMIM
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Clinical features from OMIM:

171000

Drugs & Therapeutics for Peyronie's Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Peyronie's Disease

Drug clinical trials:

Search ClinicalTrials for Peyronie's Disease

Search NIH Clinical Center for Peyronie's Disease

Search CenterWatch for Peyronie's Disease

Genetic Tests for Peyronie's Disease

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Anatomical Context for Peyronie's Disease

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32MalaCards
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MalaCards organs/tissues related to Peyronie's Disease:

32
Small intestine, Endothelial, Bone, Monocytes, Prostate

Animal Models for Peyronie's Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Peyronie's Disease:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.8DCN, POSTN, TAGLN, MSTN
2MP:00053899.4BMP6, DCN, HMOX1, PTN, TGFB1
3MP:00053829.4DCN, POSTN, NOS2, MSTN, TGFB1, CCL2
4MP:00053699.4TGFB1, MSTN, HMOX1, TAGLN, POSTN, DCN
5MP:00053709.2CCL2, SOD1, HMOX1, NOS2, MSTN, PTN
6MP:00020069.2CCL2, DCN, POSTN, TAGLN, CUL9, NOS2
7MP:00053858.7CCL2, SOD1, PDE4A, POSTN, TAGLN, HMOX1
8MP:00053868.5CCL2, SOD1, DCN, TAGLN, HMOX1, NOS2
9MP:00053848.5CCL2, SOD1, DCN, POSTN, HMOX1, CUL9
10MP:00053878.3CCL2, SOD1, PDE4A, DCN, POSTN, TAGLN
11MP:00053788.2POSTN, DCN, BMP6, CCL2, TAGLN, HMOX1
12MP:00053768.1CCL2, SOD1, DCN, POSTN, HMOX1, CUL9

Publications for Peyronie's Disease

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50PubMed
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Articles related to Peyronie's Disease:

(show top 50)    (show all 511)
idTitleAuthorsYear
1
Re: comparison between AMS 700a8c CX and Coloplasta8c titan inflatable penile prosthesis for Peyronie's disease treatment and remodeling: clinical outcomes and patient satisfaction. (23594657)
2013
2
Improvement of chronic Peyronie's disease symptoms after diabetic compensation: a retrospective study. (23434098)
2013
3
Animal experimental model of Peyronie's disease: a pilot study. (23695402)
2013
4
Clinical evaluation of natural history of Peyronie's disease: our experience, old myths and new certainties. (23909888)
2013
5
Combination of intralesional verapamil and oral antioxidants for Peyronie's disease: a prospective, randomised controlled study. (24124921)
2013
6
A new, innovative, lengthening surgical procedure for Peyronie's disease by penile prosthesis implantation with double dorsal-ventral patch graft: the "sliding technique". (22429331)
2012
7
Simultaneous penile lengthening and penile prosthesis implantation in patients with Peyronie's disease, refractory erectile dysfunction, and severe penile shortening. (22023552)
2012
8
Radiation therapy in Peyronie's disease. (22781084)
2012
9
Artificial erection in Peyronie's disease surgery. (21929922)
2011
10
Long-term results of the surgical treatment of Peyronie's disease with plaque incision and grafting. (21785446)
2011
11
Surgical option for the correction of Peyronie's disease: an autologous tissue-engineered endothelialized graft. (21718447)
2011
12
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its death receptor (DR5) in Peyronie's disease. A biomolecular study of apoptosis activation. (20840533)
2011
13
Elastosonography in the Peyronie's disease: our preliminary experience. (21341579)
2010
14
Are sonographic characteristics associated with progression to surgery in men with Peyronie's disease? (20171694)
2010
15
Experimental models of Peyronie's disease. Implications for new therapies. (19138365)
2009
16
Correlation of degree of penile curvature between patient estimates and objective measures among men with Peyronie's disease. (19284472)
2009
17
Risk factors for emotional and relationship problems in Peyronie's disease. (18638001)
2008
18
Profibrotic role of myostatin in Peyronie's disease. (18422491)
2008
19
Radiotherapy for Peyronie's Disease: a European survey. (18607879)
2008
20
Conservative treatment for Peyronie's disease: an update. (18076338)
2008
21
A Survey of primary-care physicians and urologists regarding Peyronie's disease. (17627727)
2007
22
Is intralesional interferon alpha2b a safe and effective minimally invasive treatment for Peyronie's disease? (17211421)
2007
23
Isolated septal fibrosis or hematoma--atypical Peyronie's disease? (17162033)
2007
24
Peyronie's disease: lights and shadows. (17192725)
2007
25
Patient-initiated digital photography in Peyronie's disease. (16820085)
2006
26
Peyronie's disease following long-term use of topical timolol. (16151480)
2006
27
The results of plaque incision and venous grafting (Lue procedure) to correct the penile deformity of Peyronie's disease. (15839925)
2005
28
Peyronie's disease: etiology, epidemiology and medical treatment. (16291038)
2005
29
Role of hyperthermia in the treatment of Peyronie's disease: a preliminary study. (16019862)
2005
30
Plaque incision and grafting as a salvage after a failed Nesbit procedure for Peyronie's disease. (15476526)
2004
31
Corporoplasty with saphenous venous patch graft for Peyronie's disease. (15636031)
2004
32
Therapeutic effects of colchicine in the management of Peyronie's disease: a randomized double-blind, placebo-controlled study. (14973528)
2004
33
Extracorporeal shock wave therapy for Peyronie's disease: exploratory meta-analysis of clinical trials. (14713800)
2004
34
Corporoplasty for advanced Peyronie's disease using venous and/or dermis patch grafting: new surgical technique and long-term patient satisfaction. (12576826)
2003
35
Validation of the German version of the International Index of Erectile Function (IIEF) in patients with erectile dysfunction, Peyronie's disease and controls. (12904805)
2003
36
Review of current nonsurgical management of Peyronie's disease. (14551587)
2003
37
Radiation increases fibrogenic cytokine expression by Peyronie's disease fibroblasts. (12796706)
2003
38
Experience with intraplaque injection of verapamil for Peyronie's disease. (12131321)
2002
39
Radical surgery in Peyronie's disease. Graft comparison. (12029235)
2002
40
Peyronie's disease: an anatomically-based hypothesis and beyond. (12454694)
2002
41
Peyronie's disease as a complication of chronic graft versus host disease. (12243979)
2002
42
Peyronie's disease. Embarrassing but treatable. (11692630)
2001
43
Transdermal electromotive multi-drug administration for Peyronie's disease: preliminary results. (10670523)
2000
44
Low-dose radiotherapy in 179 patients with Peyronie's disease: treatment outcome and current sexual functioning. (10889390)
2000
45
Extracorporeal shock wave therapy in the management of Peyronie's disease: initial experience. (10971273)
2000
46
Lengthening shortened penis caused by Peyronie's disease using circular venous grafting and daily stretching with a vacuum erection device. (10081856)
1999
47
Structural alterations in the tunica albuginea of the penis: impact of Peyronie's disease, ageing and impotence. (9043496)
1997
48
Ultrasound and soft-tissue radiography to monitor local interferon-alpha 2B treatment in Peyronie's disease. (8845268)
1996
49
Impotence and Peyronie's disease in systemic sclerosis. (7955618)
1994
50
Orgotein in the treatment of plastic induration of the penis (Peyronie's disease). (8365848)
1993

Genetic Variations for Peyronie's Disease

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Expression for genes affiliated with Peyronie's Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Peyronie's Disease

Search GEO for disease gene expression data for Peyronie's Disease.

Pathways for genes affiliated with Peyronie's Disease

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Sources:
55SinoBiological, 53Reactome, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN
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Pathways related to Peyronie's Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1DCN, MSTN
2
NO-dependent CFTR activation (normal and CF)
10.1NOS2, PDE5A
3
Hide members
10.0TGFB1, SERPINA1, SOD1
49.8HMOX1, DCN, CCL2
59.7BMP6, DCN, TGFB1
6
Hide members
9.2TGFB1, PTN, BMP6, IFNA2, CCL2

Compounds for genes affiliated with Peyronie's Disease

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Peyronie's Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 107)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7PDE5A
2indomethacin44 59 28 1113.5HMOX1, PDE5A
3pge24410.4TGFB1, PDE4A
4ptio4410.3SOD1, HMOX1, NOS2
53-nitrotyrosine4410.3SOD1, HMOX1, NOS2
6onoo4410.3SERPINA1, NOS2, SOD1
7ebselen4410.3NOS2, HMOX1, SOD1
8deta nonoate4410.3NOS2, HMOX1, CCL2
9taurine bromamine4410.2HMOX1, NOS2
10kt 582344 2811.2PDE5A, HMOX1, NOS2
11bleomycin44 1111.2DCN, BMP6, IFNA2
12h2o24410.2PTN, PDE4A
13diphenyleneiodonium4410.1CCL2, SOD1, NOS2, TGFB1
14cycloheximide4410.1PDE4A
15vardenafil44 1111.1PDE4A, PDE5A, NOS2
164-hydroxynonenal44 2411.1SOD1, HMOX1, NOS2, TGFB1
178-bromo cgmp4410.0PDE4A, PDE5A, NOS2
18motapizone4410.0PDE4A, PDE5A
19ng-nitro-l-arginine4410.0SOD1, PDE4A, NOS2
20pdtc4410.0CCL2, SOD1, HMOX1, NOS2, TGFB1
21sildenafil44 49 28 11 2414.0PDE4A, PDE5A, NOS2, TGFB1
22alpha lipoic acid4410.0CCL2, SOD1, HMOX1, NOS2, SERPINA1
23allopurinol44 49 1111.9HMOX1, SOD1, IFNA2
24polyethylene glycol449.8TGFB1, HMOX1, BMP6, IFNA2
2515-deoxy-delta-12,14-prostaglandin j2449.8CCL2, BMP6, HMOX1, NOS2
26ascorbic acid44 2410.8IFNA2, SOD1, HMOX1, NOS2, SERPINA1
27superoxide44 2410.7CCL2, IFNA2, PDE4A, TAGLN, HMOX1
28cyclosporin a44 28 5911.6PDE4A, HLA-S, HLA-A, DCN, HMOX1
29tgf beta1449.6CCL2, BMP6, DCN, TAGLN, TGFB1
30creatinine449.6SOD1, BMP6, DCN, SERPINA1, TGFB1
31dexamethasone44 49 28 1112.6TGFB1, MSTN, DCN, BMP6, PDE4A
32ribonucleic acid449.6CCL2, IFNA2, BMP6, DCN, MSTN, TGFB1
33glycosaminoglycan449.6TGFB1, PTN, DCN, BMP6
34sb 20358044 5910.6TGFB1, NOS2, HMOX1, BMP6, CCL2
35acetylcholine44 49 28 11 2413.5NOS2, HMOX1, TAGLN, BMP6, PDE4A
36isoproterenol44 1110.5CCL2, PDE4A, PDE5A, BMP6, NOS2
37cisplatin44 49 59 1112.5CCL2, IFNA2, SOD1, BMP6, HMOX1, TGFB1
38guanylate449.4NOS2, HMOX1, PDE5A, PDE4A
39polysaccharide449.4CCL2, BMP6, DCN, PTN, SERPINA1, TGFB1
40sodium nitroprusside449.3SOD1, PDE4A, PDE5A, BMP6, HMOX1, NOS2
41alanine449.2IFNA2, SOD1, BMP6, HLA-A, DCN, HMOX1
42prostacyclin449.2CCL2, SOD1, PDE4A, PDE5A, BMP6, HMOX1
43histamine44 28 2411.2CCL2, IFNA2, PDE4A, PDE5A, BMP6, HMOX1
44oxygen44 2410.2CCL2, PDE4A, PDE5A, DCN, HMOX1, NOS2
45ly294002449.1CCL2, PDE4A, BMP6, HMOX1, NOS2, PTN
46norepinephrine44 11 2411.0PDE4A, PDE5A, BMP6, HMOX1
47arginine448.9CCL2, SOD1, PDE4A, PDE5A, HLA-A, DCN
48retinoic acid44 249.8IFNA2, PDE4A, BMP6, DCN, TAGLN, HMOX1
49nitric oxide44 11 2410.5CCL2, SOD1, PDE4A, PDE5A, BMP6, DCN
50vegf448.4TGFB1, CCL2, IFNA2, PDE4A, PDE5A, BMP6

GO Terms for genes affiliated with Peyronie's Disease

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16Gene Ontology
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Cellular components related to Peyronie's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.3TGFB1, IFNA2, SOD1, BMP6, DCN, HMOX1

Biological processes related to Peyronie's Disease according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of superoxide anion generationGO:03293010.3TGFB1, SOD1
2response to heatGO:00940810.1MSTN, SOD1, CCL2
3response to ethanolGO:0454719.9CCL2, SOD1, MSTN
4response to hypoxiaGO:0016669.9CCL2, NOS2, SERPINA1, TGFB1
5negative regulation of neuron apoptotic processGO:0435249.9HMOX1, SOD1, CCL2
6platelet degranulationGO:0025769.9TGFB1, SERPINA1, SOD1
7response to glucocorticoid stimulusGO:0513849.8MSTN, BMP6, CCL2
8blood coagulationGO:0075969.6TGFB1, SERPINA1, NOS2, PDE5A, SOD1, IFNA2
9inflammatory responseGO:0069549.6CCL2, IFNA2, BMP6, NOS2, TGFB1
10agingGO:0075689.6CCL2, DCN, TGFB1

Molecular functions related to Peyronie's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051029.7MSTN, NOS2, HLA-A, CCL2
2heparin bindingGO:0082019.5PTN, MSTN, POSTN, CCL2
3growth factor activityGO:0080839.1BMP6, MSTN, PTN, TGFB1

Products for genes affiliated with Peyronie's Disease

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  • Antibodies
  • Proteins
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Sources for Peyronie's Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet