MCID: PYR010
MIFTS: 50

Peyronie's Disease malady

Reproductive category

Summaries for Peyronie's Disease

Sources:
43NIH Rare Diseases, 64Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Peyronie disease is a rare connective tissue disorder characterized by a plaque, or hard lump, that forms within the penis. affected individuals may experience painful, curved erections which can make make normal sexual intercourse impossible. symptoms may appear suddenly or develop gradually. while the painful erections for most men resolve over time, the scar tissue and curvature may remain. some cases appear to resolve spontaneously. the exact cause of peyronie's disease is not known. last updated: 11/23/2011

MalaCards: Peyronie's Disease, also known as peyronie disease, is related to squamous cell carcinoma and peyronies disease. An important gene associated with Peyronie's Disease is IFNA2 (interferon, alpha 2), and among its related pathways are TGF-beta Signaling Pathway and NO-dependent CFTR activation (normal and CF). The compounds estrogen and indomethacin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, prostate and t cells, and related mouse phenotypes are skeleton and reproductive system.

Wikipedia:64 Peyronie\'s disease (/peɪroʊnˈiː/), also known as induratio penis plastica or chronic inflammation... more...

Description from OMIM:47 171000

Aliases & Classifications for Peyronie's Disease

Sources:
8Disease Ontology, 43NIH Rare Diseases, 45Novoseek, 61UMLS, 35MeSH, 47OMIM, 27ICD9CM, 40NCIt, 57SNOMED-CT, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive


Aliases & Descriptions:

peyronie's disease 8
peyronie disease 8 43 45 61
balanitis xerotica obliterans 61
induratio penis plastica 8
peyronie's fibromatosis 8
penile curvature 43


External Ids:

Disease Ontology8 DOID:8616
MeSH35 D010411
OMIM47 171000
ICD9CM27 607.85
NCIt40 C3316
ICD1025 N48.6

Related Diseases for Peyronie's Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Peyronie's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma30.9BMP6, HLA-A, DCN, POSTN, TAGLN, NOS2
2peyronies disease30.3TGFB1, IFNA2, PDE5A, IPP, CUL9
3priapism30.2PDE5A
4balanitis xerotica obliterans11.4
5balanitis11.4
6lichen sclerosus10.8
7urethral stricture10.7
8hypospadias10.6
9gonorrhea10.4
10adenosquamous carcinoma10.4
11telangiectasis10.4
12pulmonary edema10.1
13devic disease10.1
14plantar fascial fibromatosis10.1
15familial dupuytren contracture10.1
16lung cancer10.0TGFB1
17prostatitis10.0PDE5A
18rhinitis10.0PDE5A
19myeloma10.0IFNA2
20vitiligo10.0SOD1
21deficiency anemia10.0IFNA2
22neuropathy10.0MSTN
23bronchopulmonary dysplasia10.0SOD1
24coronary heart disease10.0PDE5A
25essential hypertension10.0SOD1
26myopathy10.0MSTN
27kidney cancer10.0IFNA2
28pneumoconiosis10.0SOD1
29hypercholesterolemia10.0NOS2
30gastritis10.0NOS2
31biliary atresia10.0TGFB1
32skin disease10.0TGFB1
33migraine10.0PDE5A
34fibrosarcoma10.0TGFB1
35hepatopulmonary syndrome10.0HMOX1
36polyneuropathy10.0IFNA2
37alpha 1-antitrypsin deficiency10.0SERPINA1
38acute myocardial infarction10.0SERPINA1
39malaria10.0HLA-A
40ureteral obstruction10.0TGFB1
41diabetic retinopathy10.0NOS2, SOD1
42lichen planus10.0IFNA2
43nephritis10.0CCL2
44kawasaki disease10.0CCL2
45bronchiectasis10.0SERPINA1
46peritonitis10.0CCL2
47amyloidosis10.0DCN
48cryoglobulinemia10.0IFNA2
49ankylosing spondylitis10.0HLA-A
50dyspepsia10.0PDE5A

Graphical network of the top 20 diseases related to Peyronie's Disease:



Diseases related to peyronie's disease

Clinical Features for Peyronie's Disease

Sources:
47OMIM
See all sources

Clinical features from OMIM:

171000

Drugs & Therapeutics for Peyronie's Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Peyronie's Disease

Drug clinical trials:

Search ClinicalTrials for Peyronie's Disease

Search NIH Clinical Center for Peyronie's Disease

Search CenterWatch for Peyronie's Disease

Genetic Tests for Peyronie's Disease

Anatomical Context for Peyronie's Disease

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Peyronie's Disease:

33
Small intestine, Prostate, T cells, Endothelial

Animal Models for Peyronie's Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Peyronie's Disease

Sources:
51PubMed
See all sources

Articles related to Peyronie's Disease:

(show top 50)    (show all 278)
idTitleAuthorsYear
1
Penile corporoplasty with Yachia's technique for Peyronie's disease: Single center experience with 117 patients. (24049379)
2013
2
Validity and reliability of a smartphone application for the assessment of penile deformity in Peyronie's disease. (23551808)
2013
3
Peironimev-PlusAr in the treatment of chronic inflammation of tunica albuginea (Peyronie's disease). results of a controlled study. (23004005)
2013
4
Corporoplasty with small soft axial prostheses (VIRILIS IAr) and bovine pericardial graft (HYDRIXAr) in Peyronie's disease. (23353721)
2013
5
Peyronie's disease and mechanotransduction: an in vitro analysis of the cellular changes to Peyronie's disease in a cell-culture strain system. (23421851)
2013
6
A new, innovative, lengthening surgical procedure for Peyronie's disease by penile prosthesis implantation with double dorsal-ventral patch graft: the "sliding technique". (22429331)
2012
7
Penile Doppler sonographic and clinical characteristics in Peyronie's disease and/or erectile dysfunction: an analysis of 1500 men with sexual dysfunction. (22776573)
2012
8
Artificial erection in Peyronie's disease surgery. (21929922)
2011
9
Long-term results of the surgical treatment of Peyronie's disease with plaque incision and grafting. (21785446)
2011
10
Does testosterone deficiency exaggerate the clinical symptoms of Peyronie's disease? (21883492)
2011
11
Nicardipine vs. saline injection as treatment for Peyronie's disease: a prospective, randomized, single-blind trial. (20584114)
2010
12
Therapy: Intralesional nicardipine: another calcium channel blocker shown to be effective in patients with Peyronie's disease. (21113997)
2010
13
Re: Penile sonographic and clinical characteristics in men with Peyronie's disease. (20945547)
2010
14
Limited shock wave therapy vs sham treatment in men with Peyronie's disease: results of a prospective randomized controlled double-blind trial. (20438568)
2010
15
Medium-term follow-up of plaque incision and porcine small intestinal submucosal grafting for Peyronie's disease. (21124338)
2010
16
Are sonographic characteristics associated with progression to surgery in men with Peyronie's disease? (20171694)
2010
17
Stereological and biochemical analysis of muscular and connective tissue components in the penile corpus cavernosum adjacent to the fibrous plaque of Peyronie's disease. (18782314)
2009
18
A first prospective, randomized, double-blind, placebo-controlled clinical trial evaluating extracorporeal shock wave therapy for the treatment of Peyronie's disease. (19473751)
2009
19
Penile traction therapy for treatment of Peyronie's disease: a single-center pilot study. (18373527)
2008
20
Radiotherapy for Peyronie's Disease: a European survey. (18607879)
2008
21
Preservation of cavernosal erectile function after soft penile prosthesis implant in Peyronie's disease: long-term followup. (19081839)
2008
22
A Survey of primary-care physicians and urologists regarding Peyronie's disease. (17627727)
2007
23
Verapamil versus saline in electromotive drug administration for Peyronie's disease: a double-blind, placebo controlled trial. (17296390)
2007
24
Is intralesional interferon alpha2b a safe and effective minimally invasive treatment for Peyronie's disease? (17211421)
2007
25
Topical verapamil HCl, topical trifluoperazine, and topical magnesium sulfate for the treatment of Peyronie's disease--a placebo-controlled pilot study. (17367443)
2007
26
Could plaque excision surgery with sis graft induce a new fibrotic reaction in la Peyronie's disease patients? (18303735)
2007
27
Use of small intestinal submucosa graft for the surgical management of Peyronie's disease. (17976656)
2007
28
Open preliminary randomized prospective clinical trial of efficacy and safety of three different verapamil dilutions for intraplaque therapy of Peyronie's disease. (17482941)
2007
29
Surgical therapy of Peyronie's disease. (18219716)
2006
30
Long-term results of extracorporeal shockwave therapy for Peyronie's disease. (17144855)
2006
31
Surgical treatment of Peyronie's disease. (16526978)
2006
32
Surgical treatment of Peyronie's disease: a critical analysis. (16716495)
2006
33
The surgical treatment of Peyronie's disease. (16759790)
2006
34
Effect of intralesional interferon-alpha 2b combined with oral vitamin E for treatment of early stage Peyronie's disease: a randomized and prospective study. (16581113)
2006
35
Soft prosthesis implant and relaxing albugineal incision with saphenous grafting for surgical therapy of Peyronie's disease: a 5-year experience and long-term follow-up on 145 operated patients. (15661418)
2005
36
Shockwave therapy as first-line treatment for Peyronie's disease: a prospective study. (15735375)
2005
37
Relaxation incision and fascia lata grafting in the surgical correction of penile curvature in Peyronie's disease. (14707644)
2004
38
Stratification of penile vascular pathologies in patients with Peyronie's disease and in men with erectile dysfunction according to age: a comparative study. (15201789)
2004
39
Gene transfer of inducible nitric oxide synthase complementary DNA regresses the fibrotic plaque in an animal model of Peyronie's disease. (15240426)
2004
40
Combined treatment with vitamin E and colchicine in the early stages of Peyronie's disease. (12656907)
2003
41
Evaluation of extracorporeal shock wave therapy in Peyronie's disease. (12429298)
2002
42
Peyronie's disease: an unusual presentation with butterfly shaped calcified plaques. (12549650)
2002
43
Penile scintigraphy with 99mTc-human immunoglobulin G: a novel method for distinguishing the unstable and stable phases of Peyronie's disease. (12410752)
2002
44
Implications of nitric oxide synthase isoforms in the pathophysiology of Peyronie's disease. (12454685)
2002
45
Prevalence of Peyronie's disease in men over 50-y-old from Southern Brazil. (11890516)
2001
46
Pilot study on liposomal recombinant human superoxide dismutase for the treatment of Peyronie's disease. (11684853)
2001
47
Extracorporeal shock wave therapy in the management of Peyronie's disease: initial experience. (10971273)
2000
48
Peyronie's disease: etiology, medical, and surgical therapy. (10819440)
2000
49
Peyronie's disease--incision and dorsal vein grafting combined with contralateral plication in straightening the penis. (10452294)
1999
50
Peyronie's disease: a difficult sexual dysfunction problem. (9771158)
1998

Genetic Variations for Peyronie's Disease

Expression for genes affiliated with Peyronie's Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Peyronie's Disease

Search GEO for disease gene expression data for Peyronie's Disease.

Pathways for genes affiliated with Peyronie's Disease

Sources:
56SinoBiological, 54Reactome, 38NCBI BioSystems Database, 30KEGG, 52QIAGEN
See all sources

Pathways related to Peyronie's Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1DCN, MSTN
2
NO-dependent CFTR activation (normal and CF)
10.1NOS2, PDE5A
3
Hide members
10.0TGFB1, SERPINA1, SOD1
49.8HMOX1, DCN, CCL2
59.7BMP6, DCN, TGFB1
6
Hide members
9.2TGFB1, PTN, BMP6, IFNA2, CCL2

Compounds for genes affiliated with Peyronie's Disease

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Peyronie's Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 107)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7PDE5A
2indomethacin45 60 29 1113.5PDE5A, HMOX1
3pge24510.4PDE4A, TGFB1
4ptio4510.3NOS2, SOD1, HMOX1
53-nitrotyrosine4510.3SOD1, NOS2, HMOX1
6onoo4510.3SERPINA1, NOS2, SOD1
7ebselen4510.3HMOX1, SOD1, NOS2
8deta nonoate4510.3NOS2, CCL2, HMOX1
9taurine bromamine4510.2NOS2, HMOX1
10bleomycin45 1111.2DCN, BMP6, IFNA2
11h2o24510.2PDE4A, PTN
12kt 582345 2911.2HMOX1, PDE5A, NOS2
13diphenyleneiodonium4510.1NOS2, TGFB1, SOD1, CCL2
14cycloheximide4510.1PDE4A
15vardenafil45 1111.1NOS2, PDE5A, PDE4A
164-hydroxynonenal45 2411.1TGFB1, SOD1, HMOX1, NOS2
178-bromo cgmp4510.0PDE4A, NOS2, PDE5A
18ng-nitro-l-arginine4510.0NOS2, SOD1, PDE4A
19pdtc4510.0CCL2, SOD1, HMOX1, NOS2, TGFB1
20sildenafil45 50 29 11 2414.0TGFB1, NOS2, PDE5A, PDE4A
21alpha lipoic acid4510.0CCL2, NOS2, SOD1, HMOX1, SERPINA1
22motapizone4510.0PDE5A, PDE4A
23allopurinol45 50 1111.9SOD1, IFNA2, HMOX1
24polyethylene glycol459.8TGFB1, BMP6, IFNA2, HMOX1
2515-deoxy-delta-12,14-prostaglandin j2459.8NOS2, HMOX1, BMP6, CCL2
26ascorbic acid45 2410.8IFNA2, SOD1, HMOX1, SERPINA1, NOS2
27superoxide45 2410.7TAGLN, CCL2, IFNA2, HMOX1, PDE4A
28cyclosporin a45 29 6011.6PDE4A, HMOX1, DCN, HLA-A, HLA-S
29tgf beta1459.6CCL2, BMP6, DCN, TAGLN, TGFB1
30creatinine459.6DCN, BMP6, SOD1, SERPINA1, TGFB1
31dexamethasone45 50 29 1112.6MSTN, BMP6, PDE4A, TGFB1, DCN
32ribonucleic acid459.6CCL2, MSTN, BMP6, DCN, TGFB1, IFNA2
33glycosaminoglycan459.6BMP6, TGFB1, DCN, PTN
34sb 20358045 6010.6TGFB1, HMOX1, BMP6, NOS2, CCL2
35acetylcholine45 50 29 11 2413.5PDE4A, TAGLN, HMOX1, BMP6, NOS2
36isoproterenol45 1110.5NOS2, BMP6, PDE5A, PDE4A, CCL2
37cisplatin45 50 60 1112.5SOD1, HMOX1, TGFB1, BMP6, IFNA2, CCL2
38guanylate459.4PDE5A, NOS2, HMOX1, PDE4A
39polysaccharide459.4TGFB1, DCN, BMP6, PTN, CCL2, SERPINA1
40sodium nitroprusside459.3PDE4A, TGFB1, PDE5A, BMP6, HMOX1, NOS2
41alanine459.2HLA-A, HMOX1, IFNA2, DCN, SOD1, BMP6
42prostacyclin459.2PDE4A, NOS2, HMOX1, BMP6, PDE5A, SOD1
43histamine45 29 2411.2IFNA2, HMOX1, TGFB1, CCL2, BMP6, PDE4A
44oxygen45 2410.2PDE4A, MSTN, NOS2, HMOX1, DCN, CCL2
45ly294002459.1BMP6, TGFB1, PTN, NOS2, PDE4A, CCL2
46norepinephrine45 11 2411.0HMOX1, PDE5A, PDE4A, BMP6
47arginine458.9CCL2, HLA-A, NOS2, HMOX1, TAGLN, DCN
48retinoic acid45 249.8BMP6, HMOX1, DCN, PTN, TGFB1, TAGLN
49nitric oxide45 11 2410.5DCN, CCL2, SOD1, PDE4A, PDE5A, HMOX1
50vegf458.4PTN, PDE5A, BMP6, DCN, POSTN, NOS2

GO Terms for genes affiliated with Peyronie's Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Peyronie's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.3TGFB1, IFNA2, SOD1, BMP6, DCN, HMOX1

Biological processes related to Peyronie's Disease according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of superoxide anion generationGO:03293010.3SOD1, TGFB1
2response to heatGO:00940810.1SOD1, MSTN, CCL2
3response to ethanolGO:0454719.9MSTN, CCL2, SOD1
4response to hypoxiaGO:0016669.9TGFB1, SERPINA1, CCL2, NOS2
5negative regulation of neuron apoptotic processGO:0435249.9SOD1, CCL2, HMOX1
6platelet degranulationGO:0025769.9TGFB1, SOD1, SERPINA1
7response to glucocorticoid stimulusGO:0513849.8BMP6, MSTN, CCL2
8blood coagulationGO:0075969.6NOS2, SERPINA1, TGFB1, PDE5A, SOD1, IFNA2
9inflammatory responseGO:0069549.6CCL2, IFNA2, BMP6, NOS2, TGFB1
10agingGO:0075689.6TGFB1, DCN, CCL2

Molecular functions related to Peyronie's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051029.7CCL2, HLA-A, NOS2, MSTN
2heparin bindingGO:0082019.5CCL2, POSTN, MSTN, PTN
3growth factor activityGO:0080839.1BMP6, MSTN, PTN, TGFB1

Products for genes affiliated with Peyronie's Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Peyronie's Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet