MCID: PYR010
MIFTS: 56

Peyronie's Disease malady

Reproductive diseases category

Summaries for Peyronie's Disease

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42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Peyronie disease is a rare connective tissue disorder characterized by a plaque, or hard lump, that forms within the penis. affected individuals may experience painful, curved erections which can make make normal sexual intercourse impossible. symptoms may appear suddenly or develop gradually. while the painful erections for most men resolve over time, the scar tissue and curvature may remain. some cases appear to resolve spontaneously. the exact cause of peyronie's disease is not known. last updated: 11/23/2011

MalaCards: Peyronie's Disease, also known as peyronie disease, is related to squamous cell carcinoma and peyronies disease. An important gene associated with Peyronie's Disease is IFNA2 (interferon, alpha 2), and among its related pathways are TGF-beta Signaling Pathway and NO-dependent CFTR activation (normal and CF). The compounds estrogen and indomethacin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, endothelial and bone, and related mouse phenotypes are skeleton and reproductive system.

Wikipedia:63 Peyronie\'s disease or Peyronie disease (/peɪroʊnˈiː/), also known as induratio penis plastica or... more...

Description from OMIM:46 171000

Aliases & Classifications for Peyronie's Disease

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60UMLS, 8Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 34MeSH, 46OMIM, 27ICD9CM, 39NCIt, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

peyronie's disease 8
peyronie disease 8 42 44 60
balanitis xerotica obliterans 60
induratio penis plastica 8
peyronie's fibromatosis 8
penile curvature 42


External Ids:

Disease Ontology8 DOID:8616
MeSH34 D010411
OMIM46 171000
ICD9CM27 607.85
NCIt39 C3316
ICD1025 N48.6

Related Diseases for Peyronie's Disease

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Peyronie's Disease:



Diseases related to peyronie's disease

Clinical Features for Peyronie's Disease

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46OMIM
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Clinical features from OMIM:

171000

Drugs & Therapeutics for Peyronie's Disease

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Peyronie's Disease

Drug clinical trials:

Search ClinicalTrials for Peyronie's Disease

Search NIH Clinical Center for Peyronie's Disease

Search CenterWatch for Peyronie's Disease

Genetic Tests for Peyronie's Disease

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Anatomical Context for Peyronie's Disease

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32MalaCards
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MalaCards organs/tissues related to Peyronie's Disease:

32
Small intestine, Endothelial, Bone, Prostate, Monocytes

Animal Models for Peyronie's Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Peyronie's Disease:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.8DCN, POSTN, TAGLN, MSTN
2MP:00053899.4BMP6, DCN, HMOX1, PTN, TGFB1
3MP:00053829.4DCN, POSTN, NOS2, MSTN, TGFB1, CCL2
4MP:00053699.4TGFB1, MSTN, HMOX1, TAGLN, POSTN, DCN
5MP:00053709.2CCL2, SOD1, HMOX1, NOS2, MSTN, PTN
6MP:00020069.2CCL2, DCN, POSTN, TAGLN, CUL9, NOS2
7MP:00053858.7CCL2, SOD1, PDE4A, POSTN, TAGLN, HMOX1
8MP:00053868.5CCL2, SOD1, DCN, TAGLN, HMOX1, NOS2
9MP:00053848.5CCL2, SOD1, DCN, POSTN, HMOX1, CUL9
10MP:00053878.3CCL2, SOD1, PDE4A, DCN, POSTN, TAGLN
11MP:00053788.2POSTN, DCN, BMP6, CCL2, TAGLN, HMOX1
12MP:00053768.1CCL2, SOD1, DCN, POSTN, HMOX1, CUL9

Publications for Peyronie's Disease

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50PubMed
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Articles related to Peyronie's Disease:

(show top 50)    (show all 511)
idTitleAuthorsYear
1
Baseline Characteristics from an Ongoing Phase 3 Study of Collagenase Clostridium Histolyticum in Patients with Peyronie's Disease. (24112401)
2013
2
Surgical therapy of Peyronie's disease by partial plaque excision and grafting with collagen fleece: feasibility study of a new technique. (23446807)
2013
3
The clinical and psychosocial impact of Peyronie's disease. (23544796)
2013
4
Bother and distress associated with Peyronie's disease: validation of the Peyronie's disease questionnaire. (23376705)
2013
5
The role of shortening procedures for the surgical therapy of Peyronie's disease. (23703100)
2013
6
Effectiveness of antioxidants (propolis, blueberry, vitamin E) associated with verapamil in the medical management of Peyronie's disease: a study of 151 cases. (21950543)
2012
7
Comparison between AMS 700a8c CX and Coloplasta8c Titan Inflatable Penile Prosthesis for Peyronie's Disease Treatment and Remodeling: Clinical Outcomes and Patient Satisfaction. (23210973)
2012
8
Review of non-surgical treatment options for Peyronie's disease. (21918530)
2012
9
Imaging modalities and clinical assesment in men affected with Peyronie's disease. (22802839)
2011
10
Rat as an animal model for Peyronie's disease research: a review of current methods and the peer-reviewed literature. (21776004)
2011
11
Current approach to the man with acute phase Peyronie's disease--case presentation and discussion. (21631731)
2011
12
Peyronie's disease compromises the durability and component-malfunction rates in patients implanted with an inflatable penile prosthesis. (20128775)
2010
13
Therapy: Intralesional nicardipine: another calcium channel blocker shown to be effective in patients with Peyronie's disease. (21113997)
2010
14
IN-1130, a novel transforming growth factor-beta type I receptor kinase (activin receptor-like kinase 5) inhibitor, promotes regression of fibrotic plaque and corrects penile curvature in a rat model of Peyronie's disease. (19473283)
2009
15
Peyronie's disease: evaluation and review of nonsurgical therapy. (19649505)
2009
16
Effect of transdermal electromotive drug therapy on fibrogenic cytokine expression in Peyronie's disease. (19604562)
2009
17
Effect of intralesional verapamil for treatment of Peyronie's disease: a randomized single-blind, placebo-controlled study. (19199072)
2009
18
Urologist practice patterns in the management of Peyronie's disease: a nationwide survey. (18042214)
2008
19
Acute hepatitis associated with treatment of Peyronie's disease with potassium para-aminobenzoate (Potaba). (18624965)
2008
20
Measurement of penile curvature in Peyronie's disease patients: comparison of three methods. (17233785)
2007
21
Intralesional verapamil prevents the progression of Peyronie's disease. (17572211)
2007
22
Peyronie's Disease. (17983892)
2007
23
Re: porcine small intestinal submucosa is not an ideal graft material for Peyronie's disease surgery. T. John, G. Bandi and R. Santucci J Urol 2006; 176: 1025-1029. (17296450)
2007
24
An analysis of the natural history of Peyronie's disease. (16697815)
2006
25
Treatment of Peyronie's disease with oral pentoxifylline. (16470210)
2006
26
The motion: surgery is the best choice for Peyronie's disease. (16647186)
2006
27
A clinico-aetiological and ultrasonographic study of Peyronie's disease. (16800397)
2006
28
Shockwave therapy as first-line treatment for Peyronie's disease: a prospective study. (15735375)
2005
29
The surgical treatment of Peyronie's disease: replacement of plaque by free autograft of buccal mucosa. (15967262)
2005
30
Functional tissue engineering of autologous tunica albuginea: a possible graft for Peyronie's disease surgery. (15149752)
2004
31
Relationship between the severity of penile curvature and the presence of comorbidities in men with Peyronie's disease. (14713809)
2004
32
Peyronie's disease: an update of the medical management. (15102564)
2004
33
Peyronie's disease. (16422991)
2004
34
Patient and partner satisfaction and long-term results after surgical treatment for Peyronie's disease. (12837432)
2003
35
Transdermal electromotive administration of verapamil and dexamethasone for Peyronie's disease. (12780842)
2003
36
Peyronie's disease: corporoplasty using saphenous vein patch graft. (11834897)
2002
37
Peyronie's disease: an unusual presentation with butterfly shaped calcified plaques. (12549650)
2002
38
Clinical presentations of Peyronie's disease. (12454695)
2002
39
Oral propionyl-l-carnitine and intraplaque verapamil in the therapy of advanced and resistant Peyronie's disease. (12010235)
2002
40
Treatment of erectile dysfunction in patients with Peyronie's disease using sildenafil citrate. (12494281)
2002
41
Treatment of Peyronie's disease by incomplete circumferential incision of the tunica albuginea and plaque with bovine pericardium graft. (11927316)
2002
42
Long-term followup of treatment for Peyronie's disease: modeling the penis over an inflatable penile prosthesis. (11176479)
2001
43
Microsatellite alterations and loss of heterozygosity in Peyronie's disease. (10953165)
2000
44
Saphenous vein harvesting by 'stripping' technique and 'W'-shaped patch covering after plaque incision in treatment of Peyronie's disease. (11416831)
2000
45
Intralesional recombinant interferon alpha-2b in Peyronie's disease. (11037665)
2000
46
Premature ejaculation, priapism, and Peyronie's disease. (19667521)
2000
47
Evaluation of cadaveric pericardium in the rat for the surgical treatment of Peyronie's disease. (11113772)
2000
48
Immunohistochemical and quantitative study of mast cells in La Peyronie's disease. (10705196)
2000
49
Can Peyronie's disease (abnormal curvature of the penis) be corrected? (10232093)
1999
50
Symposium on Peyronie's disease Society of Impotence Research meeting at the 1997 American Urological Association meeting. (9647953)
1998

Genetic Variations for Peyronie's Disease

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Expression for genes affiliated with Peyronie's Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Peyronie's Disease

Search GEO for disease gene expression data for Peyronie's Disease.

Pathways for genes affiliated with Peyronie's Disease

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55SinoBiological, 53Reactome, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN
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Pathways related to Peyronie's Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1DCN, MSTN
2
NO-dependent CFTR activation (normal and CF)
10.1NOS2, PDE5A
3
Hide members
10.0TGFB1, SERPINA1, SOD1
49.8HMOX1, DCN, CCL2
59.7BMP6, DCN, TGFB1
6
Hide members
9.2TGFB1, PTN, BMP6, IFNA2, CCL2

Compounds for genes affiliated with Peyronie's Disease

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Peyronie's Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 107)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7PDE5A
2indomethacin44 59 28 1113.5PDE5A, HMOX1
3pge24410.4PDE4A, TGFB1
4ptio4410.3NOS2, SOD1, HMOX1
53-nitrotyrosine4410.3SOD1, NOS2, HMOX1
6onoo4410.3SERPINA1, NOS2, SOD1
7ebselen4410.3HMOX1, SOD1, NOS2
8deta nonoate4410.3NOS2, CCL2, HMOX1
9taurine bromamine4410.2NOS2, HMOX1
10bleomycin44 1111.2DCN, BMP6, IFNA2
11h2o24410.2PDE4A, PTN
12kt 582344 2811.2HMOX1, PDE5A, NOS2
13diphenyleneiodonium4410.1NOS2, TGFB1, SOD1, CCL2
14cycloheximide4410.1PDE4A
15vardenafil44 1111.1NOS2, PDE5A, PDE4A
164-hydroxynonenal44 2411.1TGFB1, SOD1, HMOX1, NOS2
178-bromo cgmp4410.0PDE4A, NOS2, PDE5A
18ng-nitro-l-arginine4410.0NOS2, SOD1, PDE4A
19pdtc4410.0CCL2, SOD1, HMOX1, NOS2, TGFB1
20sildenafil44 49 28 11 2414.0TGFB1, NOS2, PDE5A, PDE4A
21alpha lipoic acid4410.0CCL2, NOS2, SOD1, HMOX1, SERPINA1
22motapizone4410.0PDE5A, PDE4A
23allopurinol44 49 1111.9SOD1, IFNA2, HMOX1
24polyethylene glycol449.8TGFB1, BMP6, IFNA2, HMOX1
2515-deoxy-delta-12,14-prostaglandin j2449.8NOS2, HMOX1, BMP6, CCL2
26ascorbic acid44 2410.8IFNA2, SOD1, HMOX1, SERPINA1, NOS2
27superoxide44 2410.7TAGLN, CCL2, IFNA2, HMOX1, PDE4A
28cyclosporin a44 28 5911.6PDE4A, HMOX1, DCN, HLA-A, HLA-S
29tgf beta1449.6CCL2, BMP6, DCN, TAGLN, TGFB1
30creatinine449.6DCN, BMP6, SOD1, SERPINA1, TGFB1
31dexamethasone44 49 28 1112.6MSTN, BMP6, PDE4A, TGFB1, DCN
32ribonucleic acid449.6CCL2, MSTN, BMP6, DCN, TGFB1, IFNA2
33glycosaminoglycan449.6BMP6, TGFB1, DCN, PTN
34sb 20358044 5910.6TGFB1, HMOX1, BMP6, NOS2, CCL2
35acetylcholine44 49 28 11 2413.5PDE4A, TAGLN, HMOX1, BMP6, NOS2
36isoproterenol44 1110.5NOS2, BMP6, PDE5A, PDE4A, CCL2
37cisplatin44 49 59 1112.5SOD1, HMOX1, TGFB1, BMP6, IFNA2, CCL2
38guanylate449.4PDE5A, NOS2, HMOX1, PDE4A
39polysaccharide449.4TGFB1, DCN, BMP6, PTN, CCL2, SERPINA1
40sodium nitroprusside449.3PDE4A, TGFB1, PDE5A, BMP6, HMOX1, NOS2
41alanine449.2HLA-A, HMOX1, IFNA2, DCN, SOD1, BMP6
42prostacyclin449.2PDE4A, NOS2, HMOX1, BMP6, PDE5A, SOD1
43histamine44 28 2411.2IFNA2, HMOX1, TGFB1, CCL2, BMP6, PDE4A
44oxygen44 2410.2PDE4A, MSTN, NOS2, HMOX1, DCN, CCL2
45ly294002449.1BMP6, TGFB1, PTN, NOS2, PDE4A, CCL2
46norepinephrine44 11 2411.0HMOX1, PDE5A, PDE4A, BMP6
47arginine448.9CCL2, HLA-A, NOS2, HMOX1, TAGLN, DCN
48retinoic acid44 249.8BMP6, HMOX1, DCN, PTN, TGFB1, TAGLN
49nitric oxide44 11 2410.5DCN, CCL2, SOD1, PDE4A, PDE5A, HMOX1
50vegf448.4PTN, PDE5A, BMP6, DCN, POSTN, NOS2

GO Terms for genes affiliated with Peyronie's Disease

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16Gene Ontology
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Cellular components related to Peyronie's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.3TGFB1, IFNA2, SOD1, BMP6, DCN, HMOX1

Biological processes related to Peyronie's Disease according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of superoxide anion generationGO:03293010.3TGFB1, SOD1
2response to heatGO:00940810.1MSTN, SOD1, CCL2
3response to ethanolGO:0454719.9CCL2, SOD1, MSTN
4response to hypoxiaGO:0016669.9CCL2, NOS2, SERPINA1, TGFB1
5negative regulation of neuron apoptotic processGO:0435249.9HMOX1, SOD1, CCL2
6platelet degranulationGO:0025769.9TGFB1, SERPINA1, SOD1
7response to glucocorticoid stimulusGO:0513849.8MSTN, BMP6, CCL2
8blood coagulationGO:0075969.6TGFB1, SERPINA1, NOS2, PDE5A, SOD1, IFNA2
9inflammatory responseGO:0069549.6CCL2, IFNA2, BMP6, NOS2, TGFB1
10agingGO:0075689.6CCL2, DCN, TGFB1

Molecular functions related to Peyronie's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051029.7MSTN, NOS2, HLA-A, CCL2
2heparin bindingGO:0082019.5PTN, MSTN, POSTN, CCL2
3growth factor activityGO:0080839.1BMP6, MSTN, PTN, TGFB1

Products for genes affiliated with Peyronie's Disease

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Sources for Peyronie's Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet