MCID: PYR010
MIFTS: 52

Peyronie's Disease malady

Category: Reproductive diseases

Aliases & Classifications for Peyronie's Disease

About this section
Sources:
34MalaCards, 11Disease Ontology, 13DISEASES, 66UMLS, 46NIH Rare Diseases, 48Novoseek, 37MeSH, 28ICD10, 30ICD9CM, 43NCIt, 60SNOMED-CT
See all MalaCards sources

Aliases & Descriptions for Peyronie's Disease:

Name: Peyronie's Disease 34 11 13
Peyronie Disease 11 46 48 66
Balanitis Xerotica Obliterans 66
Induratio Penis Plastica 11
 
Peyronie's Fibromatosis 11
Penile Induration 37
Peyronies Disease 34
Penile Curvature 46

Classifications:



External Ids:

Disease Ontology11 DOID:8616
ICD1028 N48.6
ICD9CM30 607.85
MeSH37 D010411
NCIt43 C3316

Summaries for Peyronie's Disease

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NIH Rare Diseases:46 Peyronie disease is a connective tissue disorder characterized by a plaque, or hard lump, that forms within the penis. affected individuals may experience painful, curved erections which can make make normal sexual intercourse impossible. symptoms may appear suddenly or develop gradually. while the painful erections for most men resolve over time, the scar tissue and curvature may remain. some cases appear to resolve spontaneously. the exact cause of peyronie's disease is not known. last updated: 11/23/2011

MalaCards based summary: Peyronie's Disease, also known as peyronie disease, is related to keratopathy and hypospadias, and has symptoms including edema of penis, discharge from penis and pain in penis. An important gene associated with Peyronie's Disease is IFNA2 (Interferon Alpha 2), and among its related pathways are Glypican 1 network and TGF Beta Signaling Pathway. Affiliated tissues include small intestine, prostate and breast, and related mouse phenotypes are vision/eye and craniofacial.

Wikipedia:69 Peyronie\'s disease or Peyronie disease (/peɪroʊˈniː/), also known as induratio penis plastica (IPP)... more...

Related Diseases for Peyronie's Disease

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Diseases related to Peyronie's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
idRelated DiseaseScoreTop Affiliating Genes
1keratopathy10.5SMAD3, TGFB1
2hypospadias10.4
3naegeli-franceschetti-jadassohn syndrome/dermatopathia pigmentosa reticularis10.3DCN, TGFB1
4loin pain hematuria syndrome10.2SMAD7, TGFB1
5diamond-blackfan anemia10.2TGFB1, TGFB2
6head and neck carcinoma10.2IFNA2, SMAD3, TGFB1
7acromicric dysplasia10.2TGFB1, TGFB2
8fibrosclerosis of breast10.2TGFB1, TGFB2
9tgfbr1-related loeys-dietz syndrome10.2TGFB2, TGFB3
10loeys-dietz syndrome 410.2TGFB2, TGFB3
11peanut allergy10.2TGFB1, TGFB2
12renal clear cell carcinoma10.2TGFB2, TGFB3
13vitreous abscess10.2TGFB1, TGFB2
14beare-stevenson cutis gyrata syndrome10.2DCN, TGFB1
15leukemia10.1TGFB1, TGFB2
16brucella canis brucellosis10.1SMAD3, TGFB2
17actinomycosis10.1DCN, SMAD3, TGFB1
18vibrio vulnificus infection10.0CCL2, TGFB1
19west syndrome10.0DCN, TGFB2
20acromesomelic dysplasia9.9SMAD3, SMAD7, TGFB3
21dupuytren contracture dupuytren contracture 1, included9.9
22ledderhose disease9.9
23pulmonary edema9.9
24priapism9.9
25strawberry gallbladder9.9TGFB1, TGFB2, TGFB3
26idiopathic corneal edema9.9TGFB1, TGFB2, TGFB3
2746 xy gonadal dysgenesis9.9TGFB1, TGFB2, TGFB3
28hypopigmentation of eyelid9.9CCL2, TGFB1
29adenosine monophosphate deaminase deficiency erythrocyte type9.9SMAD3, TGFB2, TGFB3
30melorheostosis with osteopoikilosis9.8SMAD3, TGFB1
31louping ill9.8CCL2, TGFB1
32herpetic gastritis9.8TGFB2, TGFB3
33uveitis9.8CCL2, TGFB1
34gasserian ganglion meningioma9.7CCL2, TGFB2
35perrault syndrome9.7CCL2, SMAD3, TGFB1
36sinusitis9.7CCL2, TGFB1
37renal oncocytoma9.7CCL2, SMAD3, TGFB1
38diamond-blackfan anemia 39.6CCL2, SMAD3, TGFB1
39secondary lacrimal atrophy9.6CCL2, TGFB1
40nephropathy familial with hyperuricemia9.6DCN, SMAD3, SMAD7, TGFB1
41epidemic typhus9.5SMAD3, TGFB1, TGFB2, TGFB3
42exudative vitreoretinopathy 19.5CCL2, TGFB1, TGFB2
43benign neonatal seizures9.2CCL2, SMAD3, SMAD7, TGFB1
44benign struma ovarii9.2CCL2, SMAD3, SMAD7, TGFB1
45colorectal cancer8.6IFNA2, SMAD3, SMAD7, TGFB1, TGFB2, TGFB3
46twin-to-twin transfusion syndrome7.0ACTG2, CCL2, DCN, IFNA2, SMAD3, SMAD7

Comorbidity relations with Peyronie's Disease via Phenotypic Disease Network (PDN):


Bladder Neck ObstructionProstatic Hypertrophy
Urethral Stricture

Graphical network of the top 20 diseases related to Peyronie's Disease:



Diseases related to peyronie's disease

Symptoms for Peyronie's Disease

About this section

HPO human phenotypes related to Peyronie's Disease:

id Description Frequency HPO Source Accession
1 abnormality of the genitourinary system HP:0000119
2 abnormality of the skeletal system HP:0000924

UMLS symptoms related to Peyronie's Disease:


edema of penis, discharge from penis, pain in penis, penile swelling, penile burning sensation

Drugs & Therapeutics for Peyronie's Disease

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Drugs for Peyronie's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1insulinPhase 44401
2
SevelamerPhase 37352757-95-6, 152751-57-03085017
Synonyms:
Sevelamer
 
Sevelamero
Sevelamerum
Sévélamer
3
AcetylcholinePhase 275251-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
O-Acetylcholine
acetylcholine chloride
4
Testosterone enanthatePhase 1524315-37-79416
Synonyms:
17-((1-Oxoheptyl)oxy)androst-4-en-3-one
17-Hydroxyandrost-4-en-3-one, 17-heptanoate
17-Hydroxyandrost-4-en-3-one, 17-heptanoic acid
17beta-Enanthoxyandrost-4-en-3-one
17beta-Hydroxyandrost-4-en-3-one enanthate
4-Androsten-17beta-ol-3-one 17-enanthate
4-Androsten-3-one 17beta-enanthate
Androgyn L.A.
Andropository
Androtardyl
Atlatest
DEA No. 4000
DePatestrye
Delatest
Delatestryl
Depo-Testro Med
Ditate
Durathate
Everone
 
Exten test
Malogen L.A.
Malogen L.A.200
Orquisteron-E
Primotestone
Reposo TMD
Testanthate
Testate
Testenate
Testinon
Testoenant
Testonenant
Testosterone 17-enanthate
Testosterone 17beta-heptanoate
Testosterone 17beta-heptanoic acid
Testosterone enantate
Testosterone heptoate
Testosterone heptoic acid
Testosterone heptylate
Testosterone oenanthate
Testostroval
5Testosterone undecanoatePhase 1524
6vitamin dPhase 11607
7
TestosteronePhase 152458-22-06013
Synonyms:
(+)-testosterone
(+-)-8-iso-testosterone
(+-)-retrotestosterone
(+-)-testosterone
(17b)-17-hydroxy-androst-4-en-3-one
(17beta)-17-Hydroxyandrost-4-en-3-one
(8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
13-Iso-testosterone
17-Hydroxy-(17-beta)-androst-4-en-3-one
17-Hydroxy-(17beta)-androst-4-en-3-one
17-Hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one
17-Hydroxy-D4-androsten-3-one
17-Hydroxy-androst-4-en-3-one
17-beta-Hydroxy-delta(sup 4)-androsten-3-one
17-beta-Hydroxyandrost-4-en-3-one
17?-Hydroxy-4-androsten-3-one
17a-Hydroxy-(13a)-androst-4-en-3-one
17a-Hydroxy-13a-androst-4-en-3-one
17a-Hydroxy-14b-androst-4-en-3-one
17a-Hydroxy-androst-4-en-3-one
17b-Hydroxy-(10a)-androst-4-en-3-one
17b-Hydroxy-(13a)-androst-4-en-3-one
17b-Hydroxy-(8a)-androst-4-en-3-one
17b-Hydroxy-(8a,10a)-androst-4-en-3-one
17b-Hydroxy-(9b)-androst-4-en-3-one
17b-Hydroxy-(9b,10a)-androst-4-en-3-one
17b-Hydroxy-13a-androst-4-en-3-one
17b-Hydroxy-8a-androst-4-en-3-one
17b-Hydroxy-D4-androsten-3-one
17b-Hydroxy-androst-4-en-3-on
17b-Hydroxy-androst-4-en-3-one
17b-Hydroxyandrost-4-en-3-one
17b-Hydroxyandrost-4-ene-3-one
17b-Testosterone
17b-hydroxy-4-androsten-3-one
17beta-Hydroxy-3-oxo-4-androstene
17beta-Hydroxy-4-androsten-3-one
17beta-Hydroxy-delta(sup4)-androsten-3-one
17beta-Hydroxyandrost-4-en-3-one
17beta-Hydroxyandrost-4-ene-3-one
17beta-hydroxy-4-androsten-3-one
4-Androsten-17?-ol-3-one
4-Androsten-17beta-ol-3-one
4-Androsten-3-one-17b-ol
4-androsten-17β-ol-3-one
4-androstene-17beta-ol-3-one
46923_FLUKA
46923_RIEDEL
58-22-0
7-beta-Hydroxyandrost-4-en-3-one
8-Iso-testosterone
9b,10a-Testosterone
9b-Testosterone
AA 2500
AC-14899
AC1L1LM0
Andriol
Andro
Andro 100
Andro L.A. 200
AndroGel
Androderm
Androderm (TN)
Androgel
Androgel (TN)
Android 10
Android 25
Android 5
Androlin
Andronaq
Andronate 100
Andronate 200
Andropatch
Andropository 200
Androsorb
Androst-4-en-17b-ol-3-one
Androst-4-en-17beta-ol-3-one
Androst-4-ene-17b-ol-3-one
Andrusol
Andryl 200
B5DEE83F-632B-48A1-A0ED-A51E7F13DF2E
BIDD:ER0555
BIM-0061761.0001
Beta Testosterone
Bio-0678
Bio-T-Gel
C00535
CCRIS 574
CDB 111C
CHEBI:17347
CHEMBL386630
CID6013
CMC_13449
COL 1621
CP 601B
CPD000058344
Cristerona T
Cristerone T
D00075
D4-Androsten-17b-ol-3-one
DB00624
Dea No. 4000
Delatest
Delatestryl
Depo-Testadiol
Depo-Testosterone
Depo-Testosterone Cypionate
Depotest
EINECS 200-370-5
Epitestosteron
Everone 200
Geno-Cristaux Gremy
Geno-cristaux Gremy
Geno-cristaux gremy
HMS2052N11
HSDB 3398
Halotensin
Homosteron
Homosterone
 
Intrinsa
LMST02020002
LS-148813
LibiGel
Libigel
Lumitestosteron
MLS000563091
MLS001032098
MLS001306401
MLS002174283
Malerone
Malestrone
Malestrone (amps)
Malogen in Oil
Malogen, Aquaspension Injection
Malogen, aquaspension injection
Mertestate
Metandren
Methyltestosterone
MolPort-002-506-901
NCGC00091018-01
NSC 9700
Neo-Hombreol F
Neo-Testis
Neo-testis
Neotestis
Oreton
Oreton F
Oreton Methyl
Oreton-F
Orquisteron
Perandren
Percutacrine Androgenique
Percutacrine androgenique
Primotest
Primoteston
Rac-17b-hydroxy-(13a)androst-4-en-3-one
Rac-17b-hydroxy-(8a)-androst-4-en-3-one
Rac-17b-hydroxy-(9b,10a)androst-4-en-3-one
Rac-17b-hydroxy-androst-4-en-3-one
Relibra
Retrotestosterone
S00309
S2033_Selleck
SAM001246921
SMR000058344
SMR001261453
Scheinpharm Testone-Cyp
Striant
Striant (TN)
Sustanon
Sustanone
Sustason 250
Synandrol F
T-Cypionate
T1500_SIGMA
T5411_FLUKA
T5411_SIGMA
TES
Teslen
Testamone 100
Testandrone
Testaqua
Testiculosterone
Testim
Testim (TN)
Testobase
Testoderm
Testoderm Tts
Testogel
Testoject-50
Testolent
Testolin
Testopel Pellets
Testopropon
Testosteroid
Testosteron
Testosterona
Testosterona [INN-Spanish]
Testosterone
Testosterone (JAN/USP)
Testosterone Cypionate
Testosterone Enanthate
Testosterone Hydrate
Testosterone [Androgenic steroids, anabolic]
Testosterone [INN:BAN]
Testosterone and its esters
Testosterone hydrate
Testosterone solution
Testosteronum
Testosteronum [INN-Latin]
Testostosterone
Testostérone
Testoviron
Testoviron Schering
Testoviron T
Testoxyl
Testred
Testred Cypionate 200
Testrin-P.A
Testro AQ
Testro Aq
Testrone
Testryl
Tostrelle
Tostrex
Trans-Testosterone
UNII-3XMK78S47O
Viatrel
Virilon
Virilon IM
Virormone
Virosterone
ZINC06500184
beta testosterone
delta(sup 4)-Androsten-17(beta)-ol-3-one
delta4-Androsten-17beta-ol-3-one
delta4-androsten-17b-ol-3-one
testosterone
trans-Testosterone
8
MethyltestosteronePhase 152458-18-46010
Synonyms:
17(alpha)-Methyl-delta(4)-androsten-17(beta)-ol-3-one
17-Methyltestosterone
17-beta-Hydroxy-17-methylandrost-4-en-3-one
17-methyltestosterone
17alpha-Methyl-3-oxo-4-androsten-17beta-ol
17alpha-Methyl-delta(4)-androsten-17beta-ol-3-one
17alpha-Methyltestosterone
17alpha-methyl-delta-androsten-17beta-ol-3-one
17alpha-methyltestosterone
 
17beta-Hydroxy-17-methylandrost-4-en-3-one
17α-methyl-Δ4-androsten-17β-ol-3-one
17α-methyltestosterone
4-Androstene-17alpha-methyl-17beta-ol-3-one
Android
Methyltestosterone
Methyltestosteronum
Metiltestosterona
NSC-9701
Testred
Virilon
9
vitamin eNutraceuticalPhase 139259-02-914985
Synonyms:
(+)-a-Tocopherol
(+)-alpha-Tocopherol
(+)-α-tocopherol
(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL
(2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol
(2R,4'R,8'R)-a-Tocopherol
(2R,4'R,8'R)-alpha-Tocopherol
(2R,4'R,8'R)-α-tocopherol
(R,R,R)-a-Tocopherol
(R,R,R)-alpha-Tocopherol
(R,R,R)-α-tocopherol
5,7,8-Trimethyltocol
5,7,8-trimethyltocol
Amino-Opti-E
Aquasol E
D-alpha-Tocopherol
Daltose
Denamone
E-200 I.U. Softgels
 
E-Complex-600
E-Ferol
E-Vitamin succinate
Eprolin
Gordo-Vite E
Phytogermin
Phytogermine
RRR-alpha-tocopherol
RRR-alpha-tocopheryl
Tocopherol
Vitamin E
Vitamin Ea
Vitamin Plus E Softgells
Vitec
a-D-Tocopherol
a-Tocopherol
alpha-Tocopherol
alpha-delta-Tocopherol
alpha-tocopherol
d-α-tocopherol
delta-alpha-Tocopherol
10
ErgocalciferolNutraceuticalPhase 1121150-14-65280793
Synonyms:
'Ergosterol irradiated'
(+)-Vitamin D2
(3-beta,5Z,7E,22E)-9,10-Secoergosta-5,7,10,(19),22-tetraen-3-ol
(3S,5Z,7E,14xi,17alpha,22E)-9,10-secoergosta-5,7,10,22-tetraen-3-ol
(3S,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol
(3S,5Z,7E,22E)-9,10-secoergosta-5,7,10,22-tetraen-3-ol
(3beta,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol
(3beta,5Z,7e,22e)-9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol
(5E,7E,22E)-9,10-Secoergosta-5,7,10,22-tetraen-3-ol
(5Z,7E,22E)-(3S)-9,10-seco-5,7,10(19),22-ergostatetraen-3-ol
(5Z,7E,22E)-(3S)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol
(5Z,7e,22e)-(3S)-9,10-Seco-5,7,10(19),22-ergostatetraen-3-ol
(5Z,7e,22e)-(3S)-9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol
22-Tetraen 3beta 9,10,Secoergosta-5,7,10(19)-ol
31316-19-5
4-Methylene-3-[2-[tetrahydro-7a-methyl-1-(1,4,5-trimethyl-2-hexenyl)-4(3aH)-indanylidene]ethylidene]-Cyclohexanol
47768_SUPELCO
50-14-6
7489-18-1
7E677DC1-E1C4-4FC5-8F4A-BCE1857F7E87
8017-28-5
9,10,Secoergosta-5,7,10(19),22-tetraen 3.beta.-ol
9,10-Seco(5Z,7E,22E)-5,7,10(19),22-ergostatetraen-3-ol
9,10-Secoergosta-5,7,10(19),22-tetraen-3-beta-ol
9,10-Secoergosta-5,7,10(19),22-tetraen-3b-ol
95220_FLUKA
95220_SIGMA
AC-1355
AC1L1FIE
AC1NQXLH
AC1NS4DE
AC1NS9GI
AC1NSSVD
AC1NWAM3
AC1O5EDK
AC1O6WAM
ACon1_002187
Activated ergosterol
BPBio1_000418
BSPBio_000380
BSPBio_001974
Buco-D
C05441
C28H44O
CALCIFEROL IN A GELATIN MATRIX
CALCIFEROL, U.S.P.
CHEBI:28934
CHEMBL1536
CID11003810
CID3249
CID5280793
CID5315257
CID5353610
CID5356615
CID5702050
CID6432478
CID6536972
Calciferol
Calciferol (TN)
Calciferol (vitamin D2)
Calciferolum
Calciferon 2
Condacaps
Condocaps
Condol
Crtron
Crystallina
D-Arthin
D-Tracetten
D00187
DB00153
Daral
Davitamon D
Davitin
De-rat concentrate
Decaps
Dee-Osterol
Dee-Ron
Dee-Ronal
Dee-Roual
Deltalin
Deratol
Detalup
Diactol
Divit urto
Doral
Drisdol
Drisdol (TN)
E5750_SIGMA
EINECS 200-014-9
Ercalciol
Ergocalciferol
Ergocalciferol (D2)
Ergocalciferol (JP15/USP)
Ergocalciferol [INN:BAN:JAN]
Ergocalciferol oil
Ergocalciferol: Vitamin D
 
Ergocalciferolo
Ergocalciferolo [DCIT]
Ergocalciferols
Ergocalciferolum
Ergocalciferolum [INN-Latin]
Ergorone
Ergosterol activated
Ergosterol irradiated
Ergosterol, irradiated
Ertron
Fortodyl
Geltabs
Geltabs Vitamin D
HMS1920K20
HMS2091B19
HMS502I07
HSDB 819
Haliver
Hi-Deratol
Hyperkil
I05-0022
IDI1_000805
Infron
Irradiated ergosta-5,7,22-trien-3-beta-ol
Irradiated ergosta-5,7,22-trien-3.beta.-ol
Irradiated ergosta-5,7,22-trien-3beta-ol
Irradiated ergosterol
LMST03010001
LMST03010014
LS-3228
MEGxm0_000466
MLS001332467
MLS001332468
Metadee
Mina D2
MolPort-001-740-057
MolPort-001-793-930
MolPort-002-526-645
MolPort-003-666-178
MolPort-006-822-629
Mulsiferol
Mykostin
NCGC00142497-01
NCGC00179579-01
NCGC00179579-02
NSC 62792
NSC62792
Novovitamin-D
Oleovitamin D
Oleovitamin D, Synthetic
Oleovitamin D2
Osteil
Ostelin
Prestwick3_000420
Prestwick_554
Radiostol
Radstein
Radsterin
Rodine C
Rodinec
SMR000857106
SPECTRUM1500276
ST057150
STOCK1N-53397
Shock-ferol
Shock-ferol sterogyl
Sorex C.R
Sorex C.R.
Spectrum5_000666
Sterogyl
Synthetic Vitamin D
UNII-VS041H42XC
Uvesterol D
Uvesterol-D
VITAMIN D2
VITAMIN D2 WATER DISPERSABLE U.S.P.
VITAMIN_D2
Vigantol
Vio D
Vio-D
Viostdrol
Viosterol
Viosterol in Oil
Vitamin D2
Vitamin- D2
Vitamin-?D2
Vitamina D2
Vitavel-D
WLN: L56 FYTJ A1 BY1&1U1Y1&Y1&1 FU2U- BL6YYTJ AU1 DQ
ZINC04474571
ZINC04629876
beta-Ol
bmse000510
component of Geltabs Vitamin D
delta-Arthin
delta-Tracetten
ergocalciferol
vitamin d-2
11TocotrienolNutraceuticalPhase 1391
12TocopherolNutraceuticalPhase 1395

Interventional clinical trials:

(show all 20)
idNameStatusNCT IDPhase
1Obtain a Good Blood Glucose Control With the Paradigm Real Time SystemRecruitingNCT00441129Phase 4
2Long-term Safety, Curvature Deformity Characterization, and Immunogenicity Over Time in Subjects Previously Treated With AA4500 for Peyronies DiseaseActive, not recruitingNCT02298829Phase 4
3Study of AA4500 in the Treatment of Peyronie's DiseaseCompletedNCT01221597Phase 3
4A Study of AA4500 in Men With Peyronie's DiseaseCompletedNCT01243411Phase 3
5Study of AA4500 in the Treatment of Peyronie's DiseaseCompletedNCT01221623Phase 3
6A Phase 3, Open-label Study of the Safety and Effectiveness of AA4500 Administered Twice Per Treatment Cycle for up to Four Treatment Cycles (2 x 4) in Men With Peyronie's DiseaseCompletedNCT01685437Phase 3
7An Open-label Study to Assess the Safety and Effectiveness of AA4500 in Combination With the ErecAid® Esteem® Manual Vacuum Therapy System in Treating Men With Peyronie's DiseaseCompletedNCT02267460Phase 3
8A Randomised, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Sevelamer Carbonate Tablets Dosed Three Times a Day in Hyperphosphataemic Chronic Kidney Disease Patients Not on DialysisTerminatedNCT00833768Phase 3
9The Safety and Effectiveness of AA4500 in Subjects With Peyronie's DiseaseCompletedNCT00755222Phase 2
10Pharmacokinetics of a Single Treatment Cycle of AA4500 0.58 mg in Men With Peyronie's DiseaseCompletedNCT01430169Phase 2
11H-22411: BOTOX® for Peyronie's DiseaseRecruitingNCT00812838Phase 2
12Dupuytren's Disease and Extracorporeal Shockwave Therapy (DupuyShock-2010)RecruitingNCT01184586Phase 2
13Peyronie's Disease Treatment ProtocolCompletedNCT02072018Phase 1
14Evaluate the Safety and Feasibility of Injecting PMD-MSC Into the Penis to Treat the Symptoms of PDCompletedNCT02395029Phase 1
15Testosterone Pellets Plus Vitamin D and E Versus Vitamin D and E Alone for the Treatment of Peyronie's DiseaseActive, not recruitingNCT01578473Phase 1
16Change in Penile Length Following Bilateral Nerve-Sparing Radical ProstatectomyCompletedNCT00800813
17Management of Peyronie's Disease With Adipose Tissue Stem CellRecruitingNCT02414308
18Safety and Clinical Outcomes Study: SVF Deployment for Orthopedic, Neurologic, Urologic, and Cardio-pulmonary ConditionsRecruitingNCT01953523
19Pregnant Women With a Breast Cancer Diagnosed Between 2000 and 2014RecruitingNCT01503034
20Efficacy of Extracorporal Shock Wave Therapy in Patient With Chronic Non-bacterial Prostatitis / Chronic Pelvic Pain SyndromeActive, not recruitingNCT01714830

Search NIH Clinical Center for Peyronie's Disease


Cochrane evidence based reviews: penile induration

Genetic Tests for Peyronie's Disease

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Anatomical Context for Peyronie's Disease

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MalaCards organs/tissues related to Peyronie's Disease:

34
Small intestine, Prostate, Breast, Kidney, Endothelial, Monocytes, Testes

Animal Models for Peyronie's Disease or affiliated genes

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MGI Mouse Phenotypes related to Peyronie's Disease:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.3DCN, SMAD3, TGFB1, TGFB2, TGFB3
2MP:00053827.9DCN, SMAD3, SMAD7, TGFB1, TGFB2, TGFB3
3MP:00053817.6DCN, SMAD3, SMAD7, TGFB1, TGFB2, TGFB3

Publications for Peyronie's Disease

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Articles related to Peyronie's Disease:

(show top 50)    (show all 611)
idTitleAuthorsYear
1
Satisfaction of patients with Peyronie's disease after plaque surgery and bovine pericardium graft. (27468940)
2016
2
The Effect of Duration of Penile Traction Therapy in Patients Undergoing Intralesional Injection Therapy for Peyronie's Disease. (25804087)
2015
3
Intralesional Interferon-I+2b Improves Penile Curvature in Peyronie's Disease. (26386274)
2015
4
Commentary On: Peyronie's Disease and Autoimmunity-A Real-Life Clinical Study and Comprehensive Review. (25736299)
2015
5
Psychosexual Symptoms and Treatment of Peyronie's Disease Within a Collaborative Care Model. (25548648)
2014
6
Peyronie's disease: review and recent advances. (24984940)
2014
7
Silencing histone deacetylase 2 using small hairpin RNA induces regression of fibrotic plaque in a rat model of Peyronie's disease. (24841412)
2014
8
Baseline Characteristics from an Ongoing Phase 3 Study of Collagenase Clostridium Histolyticum in Patients with Peyronie's Disease. (24112401)
2013
9
Penile corporoplasty with Yachia's technique for Peyronie's disease: Single center experience with 117 patients. (24049379)
2013
10
Surgery for Peyronie's disease. (23178395)
2013
11
The clinical and psychosocial impact of Peyronie's disease. (23544796)
2013
12
Re: long-term results of the surgical treatment of Peyronie's disease with Egydio's technique: a European multicentre study. (22325532)
2012
13
A new, innovative, lengthening surgical procedure for Peyronie's disease by penile prosthesis implantation with double dorsal-ventral patch graft: the "sliding technique". (22429331)
2012
14
Safety and tolerability of local treatment with iloprost, a prostacyclin analogue, in patients with Peyronie's disease: a phase I study. (22176734)
2012
15
Comparison between AMS 700a8c CX and Coloplasta8c Titan Inflatable Penile Prosthesis for Peyronie's Disease Treatment and Remodeling: Clinical Outcomes and Patient Satisfaction. (23210973)
2012
16
Re: The Role of Vacuum Pump Therapy to Mechanically Straighten the Penis in Peyronie's Disease. (22088643)
2011
17
Risk factors of Peyronie's disease. What does our clinical experience show? (20955309)
2011
18
Current surgical management of severe peyronie's disease. (21098900)
2010
19
Predicting delay in presentation in men with Peyronie's disease. (20929519)
2010
20
The combination of vein grafting and two different types of corporeal plication in complex curvature due to Peyronie's disease. (20389155)
2010
21
Nicardipine vs. saline injection as treatment for Peyronie's disease: a prospective, randomized, single-blind trial. (20584114)
2010
22
Medical management of Peyronie's disease. (18974422)
2009
23
Risk factors for emotional and relationship problems in Peyronie's disease. (18638001)
2008
24
Comparison of vitamin E and propionyl-L-carnitine, separately or in combination, in patients with early chronic Peyronie's disease: a double-blind, placebo controlled, randomized study. (17706714)
2007
25
The natural history of Peyronie's disease. (17601314)
2007
26
The use of collagenase in the treatment of Peyronie's disease M.K. Gelbard, A. Lindner, and J.J. Kaufman. (17727345)
2007
27
Surgical therapy of Peyronie's disease. (18219716)
2006
28
Evaluation of post-operative residual function of corpora cavernosa after soft penile prosthesis implant for Peyronie's disease. (16929602)
2006
29
A critical analysis of nonsurgical treatment of Peyronie's disease. (16698449)
2006
30
The results of plaque incision and venous grafting (Lue procedure) to correct the penile deformity of Peyronie's disease. (15839925)
2005
31
A surgical algorithm for men with combined Peyronie's disease and erectile dysfunction: functional and satisfaction outcomes. (16422916)
2005
32
Conservative management options for Peyronie's disease. (16238920)
2005
33
Alpha-1-antitrypsin levels and genetic variation of the alpha-1-antitrypsin gene in Peyronie's disease. (15474273)
2004
34
Corporoplasty with saphenous venous patch graft for Peyronie's disease. (15636031)
2004
35
Questionable efficacy of extracorporeal shock wave therapy for Peyronie's disease: results of a prospective approach. (14665898)
2004
36
Stratification of penile vascular pathologies in patients with Peyronie's disease and in men with erectile dysfunction according to age: a comparative study. (15201789)
2004
37
Patient and partner satisfaction and long-term results after surgical treatment for Peyronie's disease. (12837432)
2003
38
Peyronie's disease. Who is at risk? (12518211)
2002
39
Intralesional interferon-alpha-2b for the treatment of Peyronie's disease. (12454683)
2002
40
Management of Peyronie's disease--a review. (11550782)
2001
41
Peyronie's disease. (11402589)
2001
42
Current sexual functioning in 106 patients with Peyronie's disease treated with radiotherapy 9 years earlier. (11113753)
2000
43
The use of betamethasone and hyaluronidase injections in the treatment of Peyronie's disease. (11195899)
2000
44
Microsatellite alterations and loss of heterozygosity in Peyronie's disease. (10953165)
2000
45
Evidence based assessment of long-term results of plaque incision and vein grafting for Peyronie's disease. (10799165)
2000
46
Saphenous vein harvesting by 'stripping' technique and 'W'-shaped patch covering after plaque incision in treatment of Peyronie's disease. (11416831)
2000
47
Intralesional recombinant interferon alpha-2b in Peyronie's disease. (11037665)
2000
48
Peyronie's disease: current management. (10465229)
1999
49
Vein grafting of tunical incisions in the treatment of Peyronie's disease. (10349258)
1998
50
La Peyronie's disease. Our experience]. (2186297)
1990

Variations for Peyronie's Disease

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Expression for genes affiliated with Peyronie's Disease

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Search GEO for disease gene expression data for Peyronie's Disease.

Pathways for genes affiliated with Peyronie's Disease

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Pathways related to Peyronie's Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 58)
idSuper pathwaysScoreTop Affiliating Genes
19.7TGFB1, TGFB3
29.2SMAD3, SMAD7, TGFB1
3
Show member pathways
9.2SMAD3, SMAD7, TGFB1
49.2SMAD3, SMAD7, TGFB1
5
Show member pathways
9.2SMAD3, SMAD7, TGFB1
6
Show member pathways
9.2SMAD7, TGFB1, TGFB3
7
Show member pathways
9.1SMAD3, TGFB1, TGFB2
8
Show member pathways
9.1SMAD3, TGFB1, TGFB2
9
Show member pathways
9.1TGFB1, TGFB2, TGFB3
109.1TGFB1, TGFB2, TGFB3
119.1TGFB1, TGFB2, TGFB3
129.1TGFB1, TGFB2, TGFB3
139.1TGFB1, TGFB2, TGFB3
14
Show member pathways
9.1TGFB1, TGFB2, TGFB3
159.1TGFB1, TGFB2, TGFB3
16
Show member pathways
9.1TGFB1, TGFB2, TGFB3
178.8SMAD3, SMAD7, TGFB1, TGFB3
188.8IFNA2, TGFB1, TGFB2, TGFB3
19
Show member pathways
8.7SMAD3, TGFB1, TGFB2, TGFB3
20
Show member pathways
8.7SMAD3, TGFB1, TGFB2, TGFB3
21
Show member pathways
8.7SMAD3, TGFB1, TGFB2, TGFB3
228.7SMAD3, TGFB1, TGFB2, TGFB3
238.7SMAD3, TGFB1, TGFB2, TGFB3
24
Show member pathways
8.7SMAD3, TGFB1, TGFB2, TGFB3
258.7SMAD3, TGFB1, TGFB2, TGFB3
268.7SMAD3, TGFB1, TGFB2, TGFB3
278.7SMAD3, TGFB1, TGFB2, TGFB3
28
Show member pathways
8.7SMAD3, TGFB1, TGFB2, TGFB3
298.7SMAD3, TGFB1, TGFB2, TGFB3
30
Show member pathways
8.7SMAD3, TGFB1, TGFB2, TGFB3
31
Show member pathways
8.6DCN, TGFB1, TGFB2, TGFB3
328.6DCN, TGFB1, TGFB2, TGFB3
338.6DCN, TGFB1, TGFB2, TGFB3
34
Show member pathways
8.6ACTG2, TGFB1, TGFB2, TGFB3
35
Show member pathways
8.4IFNA2, SMAD3, TGFB1, TGFB2, TGFB3
368.3CCL2, TGFB1, TGFB2, TGFB3
378.3CCL2, TGFB1, TGFB2, TGFB3
38
Show member pathways
8.3CCL2, TGFB1, TGFB2, TGFB3
39
Show member pathways
8.3DCN, SMAD3, TGFB1, TGFB2, TGFB3
408.2ACTG2, SMAD3, TGFB1, TGFB2, TGFB3
418.2SMAD3, SMAD7, TGFB1, TGFB2, TGFB3
428.2SMAD3, SMAD7, TGFB1, TGFB2, TGFB3
438.2SMAD3, SMAD7, TGFB1, TGFB2, TGFB3
447.9CCL2, SMAD3, TGFB1, TGFB2, TGFB3
45
Show member pathways
7.7DCN, SMAD3, SMAD7, TGFB1, TGFB2, TGFB3
46
Show member pathways
7.6CCL2, IFNA2, SMAD3, TGFB1, TGFB2, TGFB3
47
Show member pathways
7.6CCL2, IFNA2, SMAD3, TGFB1, TGFB2, TGFB3
48
Show member pathways
7.6CCL2, IFNA2, SMAD3, TGFB1, TGFB2, TGFB3
49
Show member pathways
7.4ACTG2, CCL2, SMAD3, TGFB1, TGFB2, TGFB3
50
Show member pathways
7.4CCL2, SMAD3, SMAD7, TGFB1, TGFB2, TGFB3

GO Terms for genes affiliated with Peyronie's Disease

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Cellular components related to Peyronie's Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.7TGFB1, TGFB2, TGFB3
2extracellular matrixGO:00310128.9DCN, TGFB1, TGFB2, TGFB3
3neuronal cell bodyGO:00430258.3CCL2, TGFB1, TGFB2, TGFB3
4extracellular regionGO:00055767.5CCL2, DCN, IFNA2, TGFB1, TGFB2, TGFB3
5extracellular spaceGO:00056156.9ACTG2, CCL2, DCN, IFNA2, TGFB1, TGFB2

Biological processes related to Peyronie's Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 64)
idNameGO IDScoreTop Affiliating Genes
1regulation of bindingGO:005109810.5SMAD3, TGFB1
2positive regulation of extracellular matrix assemblyGO:190120310.5SMAD3, TGFB1
3evasion or tolerance of host defenses by virusGO:001904910.5SMAD3, TGFB1
4SMAD protein complex assemblyGO:000718310.4SMAD3, TGFB1
5frontal suture morphogenesisGO:006036410.4TGFB1, TGFB3
6regulation of epithelial to mesenchymal transition involved in endocardial cushion formationGO:190500510.4TGFB1, TGFB3
7regulation of striated muscle tissue developmentGO:001620210.4SMAD3, TGFB1
8negative regulation of DNA replicationGO:000815610.4TGFB1, TGFB3
9lens fiber cell differentiationGO:007030610.3SMAD3, TGFB1
10ossification involved in bone remodelingGO:004393210.3TGFB1, TGFB3
11positive regulation of SMAD protein import into nucleusGO:006039110.2TGFB1, TGFB3
12regulation of transforming growth factor beta2 productionGO:003290910.2SMAD3, TGFB2
13uterine wall breakdownGO:004270410.1TGFB2, TGFB3
14positive regulation of protein localization to nucleusGO:190018210.1TGFB1, TGFB2
15negative regulation of immune responseGO:005077710.1TGFB1, TGFB2
16positive regulation of bone mineralizationGO:003050110.0SMAD3, TGFB1, TGFB3
17response to laminar fluid shear stressGO:00346169.9SMAD7, TGFB1, TGFB3
18SMAD protein import into nucleusGO:00071849.8TGFB1, TGFB2, TGFB3
19salivary gland morphogenesisGO:00074359.8TGFB1, TGFB2, TGFB3
20extrinsic apoptotic signaling pathwayGO:00971919.7SMAD3, TGFB1, TGFB2
21positive regulation of cell-cell adhesionGO:00224099.7CCL2, SMAD7
22positive regulation of cell divisionGO:00517819.7TGFB1, TGFB2, TGFB3
23regulation of transforming growth factor beta receptor signaling pathwayGO:00170159.7SMAD3, SMAD7, TGFB1
24negative regulation of macrophage cytokine productionGO:00109369.7TGFB1, TGFB2, TGFB3
25pathway-restricted SMAD protein phosphorylationGO:00603899.6SMAD7, TGFB1, TGFB2
26platelet degranulationGO:00025769.6TGFB1, TGFB2, TGFB3
27ureteric bud developmentGO:00016579.6SMAD3, SMAD7, TGFB1
28positive regulation of pathway-restricted SMAD protein phosphorylationGO:00108629.6TGFB1, TGFB2, TGFB3
29cell cycle arrestGO:00070509.6SMAD3, TGFB1, TGFB2
30negative regulation of gene expressionGO:00106299.6IFNA2, TGFB1, TGFB2
31cell growthGO:00160499.6TGFB1, TGFB2, TGFB3
32glial cell migrationGO:00083479.6CCL2, TGFB2
33negative regulation of cell growthGO:00303089.5SMAD3, TGFB1, TGFB2
34positive regulation of collagen biosynthetic processGO:00329679.4CCL2, TGFB1, TGFB3
35face morphogenesisGO:00603259.4TGFB1, TGFB2, TGFB3
36positive regulation of protein secretionGO:00507149.4TGFB1, TGFB2, TGFB3
37SMAD protein signal transductionGO:00603959.3SMAD3, TGFB1, TGFB2, TGFB3
38cytokine-mediated signaling pathwayGO:00192219.3CCL2, DCN, IFNA2
39cell-cell junction organizationGO:00452169.3SMAD3, TGFB1, TGFB2, TGFB3
40positive regulation of epithelial to mesenchymal transitionGO:00107189.2SMAD3, TGFB1, TGFB2, TGFB3
41response to woundingGO:00096119.2CCL2, TGFB1, TGFB2
42negative regulation of transforming growth factor beta receptor signaling pathwayGO:00305129.2SMAD3, SMAD7, TGFB1, TGFB3
43positive regulation of gene expressionGO:00106288.8ACTG2, SMAD3, TGFB1, TGFB2
44negative regulation of cell proliferationGO:00082858.8SMAD3, TGFB1, TGFB2, TGFB3
45agingGO:00075688.7CCL2, DCN, TGFB1, TGFB3
46response to progesteroneGO:00325708.4CCL2, TGFB1, TGFB2, TGFB3
47wound healingGO:00420608.3DCN, SMAD3, TGFB1, TGFB2, TGFB3
48positive regulation of transcription from RNA polymerase II promoterGO:00459448.1DCN, SMAD3, SMAD7, TGFB1, TGFB3
49transforming growth factor beta receptor signaling pathwayGO:00071798.0CCL2, SMAD3, SMAD7, TGFB1, TGFB2, TGFB3
50response to hypoxiaGO:00016667.8CCL2, SMAD3, TGFB1, TGFB2, TGFB3

Molecular functions related to Peyronie's Disease according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1type I transforming growth factor beta receptor bindingGO:00347139.8SMAD7, TGFB1, TGFB3
2type III transforming growth factor beta receptor bindingGO:00347149.7TGFB1, TGFB2, TGFB3
3type II transforming growth factor beta receptor bindingGO:00051149.7TGFB1, TGFB2, TGFB3
4transforming growth factor beta receptor bindingGO:00051609.7SMAD3, TGFB1, TGFB2
5collagen bindingGO:00055189.3DCN, SMAD3, SMAD7
6growth factor activityGO:00080839.3TGFB1, TGFB2, TGFB3
7protein heterodimerization activityGO:00469828.7SMAD3, TGFB1, TGFB2, TGFB3
8cytokine activityGO:00051258.2CCL2, IFNA2, TGFB1, TGFB2, TGFB3

Sources for Peyronie's Disease

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet