MCID: PYR010
MIFTS: 53

Peyronie's Disease malady

Rare diseases, Reproductive diseases categories

Summaries for Peyronie's Disease

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Sources:
44NIH Rare Diseases, 66Wikipedia, 48OMIM, 34MalaCards
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NIH Rare Diseases:44 Peyronie disease is a rare connective tissue disorder characterized by a plaque, or hard lump, that forms within the penis. affected individuals may experience painful, curved erections which can make make normal sexual intercourse impossible. symptoms may appear suddenly or develop gradually. while the painful erections for most men resolve over time, the scar tissue and curvature may remain. some cases appear to resolve spontaneously. the exact cause of peyronie's disease is not known. last updated: 11/23/2011

MalaCards: Peyronie's Disease, also known as peyronie disease, is related to peyronies disease and hypospadias. An important gene associated with Peyronie's Disease is IFNA2 (interferon, alpha 2), and among its related pathways are Type II interferon signaling (IFNG) and NOD-like Receptor Signaling Pathways. The compounds toremifene and genipin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, endothelial and bone, and related mouse phenotypes are adipose tissue and digestive/alimentary.

Wikipedia:66 Peyronie\'s disease or Peyronie disease (/pe?ro??ni?/), also known as induratio penis plastica (IPP) or... more...

Description from OMIM:48 171000

Aliases & Classifications for Peyronie's Disease

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9Disease Ontology, 44NIH Rare Diseases, 46Novoseek, 63UMLS, 59SNOMED-CT, 48OMIM, 28ICD9CM, 41NCIt, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Reproductive diseases


Aliases & Descriptions:

peyronie's disease 9
peyronie disease 9 44 46 63
balanitis xerotica obliterans 63
induratio penis plastica 9
peyronie's fibromatosis 9
penile curvature 44


External Ids:

Disease Ontology9 DOID:8616
OMIM48 171000
ICD9CM28 607.85
NCIt41 C3316
MeSH36 D010411
ICD1026 N48.6

Related Diseases for Peyronie's Disease

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Peyronie's Disease:



Diseases related to peyronie's disease

Symptoms for Peyronie's Disease

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48OMIM
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Clinical features from OMIM:

171000

Drugs & Therapeutics for Peyronie's Disease

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Peyronie's Disease

Drug clinical trials:

Search ClinicalTrials for Peyronie's Disease

Search NIH Clinical Center for Peyronie's Disease

Search CenterWatch for Peyronie's Disease

Genetic Tests for Peyronie's Disease

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Anatomical Context for Peyronie's Disease

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34MalaCards
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MalaCards organs/tissues related to Peyronie's Disease:

34
Small intestine, Endothelial, Bone, Monocytes, Prostate

Animal Models for Peyronie's Disease or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Peyronie's Disease:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.0NOS2, MSTN, TGFB1
2MP:00053818.8NOS2, MSTN, TGFB1
3MP:00053828.7NOS2, MSTN, TGFB1
4MP:00053678.5TGFB1, MSTN, NOS2
5MP:00053708.2NOS2, MSTN, SOD1, TGFB1
6MP:00053698.2TGFB1, SOD1, MSTN, NOS2
7MP:00053858.2TGFB1, SOD1, MSTN, NOS2
8MP:00053868.1TGFB1, SOD1, MSTN, NOS2
9MP:00053878.1NOS2, MSTN, SOD1, TGFB1
10MP:00053848.0TGFB1, SOD1, MSTN, NOS2

Publications for Peyronie's Disease

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Sources:
53PubMed
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Articles related to Peyronie's Disease:

(show top 50)    (show all 506)
idTitleAuthorsYear
1
Re: Penile Corporoplasty with Yachia's Technique for Peyronie's Disease: Single Center Experience with 117 Patients. (24411890)
2014
2
Surgical therapy of Peyronie's disease by partial plaque excision and grafting with collagen fleece: feasibility study of a new technique. (23446807)
2013
3
Peyronie's disease in Minoan art. (23578389)
2013
4
Penile corporoplasty with Yachia's technique for Peyronie's disease: Single center experience with 117 patients. (24049379)
2013
5
Re: long-term results of the surgical treatment of Peyronie's disease with Egydio's technique: a European multicentre study. (22325532)
2012
6
Update on plication procedures for Peyronie's disease and other penile deformities. (23205060)
2012
7
A new, innovative, lengthening surgical procedure for Peyronie's disease by penile prosthesis implantation with double dorsal-ventral patch graft: the "sliding technique". (22429331)
2012
8
Effectiveness of antioxidants (propolis, blueberry, vitamin E) associated with verapamil in the medical management of Peyronie's disease: a study of 151 cases. (21950543)
2012
9
Peyronie's disease: perspectives on therapeutic targets. (21492024)
2011
10
Re: The Role of Vacuum Pump Therapy to Mechanically Straighten the Penis in Peyronie's Disease. (22088643)
2011
11
Imaging modalities and clinical assesment in men affected with Peyronie's disease. (22802839)
2011
12
Risk factors of Peyronie's disease. What does our clinical experience show? (20955309)
2011
13
Pentoxifylline treatment and penile calcifications in men with Peyronie's disease. (21102473)
2011
14
Inflatable penile prosthesis placement in men with Peyronie's disease and drug-resistant erectile dysfunction: A single-center study. (20722782)
2010
15
Current surgical management of severe peyronie's disease. (21098900)
2010
16
Is there a place for conservative treatment in Peyronie's disease? (19338644)
2009
17
Use of penile extender device in the treatment of penile curvature as a result of Peyronie's disease. Results of a phase II prospective study. (19138361)
2009
18
The effectiveness of transdermal electromotive administration with verapamil and dexamethasone in the treatment of Peyronie's disease. (18592390)
2009
19
Stereological and biochemical analysis of muscular and connective tissue components in the penile corpus cavernosum adjacent to the fibrous plaque of Peyronie's disease. (18782314)
2009
20
Penile traction therapy for treatment of Peyronie's disease: a single-center pilot study. (18373527)
2008
21
The chronology of depression and distress in men with Peyronie's disease. (18554257)
2008
22
Surgical treatment of Peyronie's disease: choosing the best approach to improve patient satisfaction. (18087656)
2008
23
Experience with plaque excision and dermal grafting in the surgical treatment of Peyronie's disease. (18946615)
2008
24
Risk factors for emotional and relationship problems in Peyronie's disease. (18638001)
2008
25
Comparison of vitamin E and propionyl-L-carnitine, separately or in combination, in patients with early chronic Peyronie's disease: a double-blind, placebo controlled, randomized study. (17706714)
2007
26
A Survey of primary-care physicians and urologists regarding Peyronie's disease. (17627727)
2007
27
The natural history of Peyronie's disease. (17601314)
2007
28
Graft materials in Peyronie's disease surgery: a comprehensive review. (17419820)
2007
29
Surgical therapy of Peyronie's disease. (18219716)
2006
30
Evaluation of post-operative residual function of corpora cavernosa after soft penile prosthesis implant for Peyronie's disease. (16929602)
2006
31
A critical analysis of nonsurgical treatment of Peyronie's disease. (16698449)
2006
32
The results of plaque incision and venous grafting (Lue procedure) to correct the penile deformity of Peyronie's disease. (15839925)
2005
33
A surgical algorithm for men with combined Peyronie's disease and erectile dysfunction: functional and satisfaction outcomes. (16422916)
2005
34
Alpha-1-antitrypsin levels and genetic variation of the alpha-1-antitrypsin gene in Peyronie's disease. (15474273)
2004
35
Corporoplasty for advanced Peyronie's disease using venous and/or dermis patch grafting: new surgical technique and long-term patient satisfaction. (12576826)
2003
36
Prospective analysis of HLA classes I and II antigen frequency in patients with Peyronie's disease. (14501786)
2003
37
Experience with intraplaque injection of verapamil for Peyronie's disease. (12131321)
2002
38
Peyronie's disease. Who is at risk? (12518211)
2002
39
Management of Peyronie's disease--a review. (11550782)
2001
40
Peyronie's disease in men under age 40: characteristics and outcome. (11313836)
2001
41
Current sexual functioning in 106 patients with Peyronie's disease treated with radiotherapy 9 years earlier. (11113753)
2000
42
The use of betamethasone and hyaluronidase injections in the treatment of Peyronie's disease. (11195899)
2000
43
Microsatellite alterations and loss of heterozygosity in Peyronie's disease. (10953165)
2000
44
Evidence based assessment of long-term results of plaque incision and vein grafting for Peyronie's disease. (10799165)
2000
45
Saphenous vein harvesting by 'stripping' technique and 'W'-shaped patch covering after plaque incision in treatment of Peyronie's disease. (11416831)
2000
46
Tamoxifen versus placebo in the treatment of Peyronie's disease. (10569556)
1999
47
Atypical Peyronie's disease. (10468781)
1999
48
Vein grafting of tunical incisions in the treatment of Peyronie's disease. (10349258)
1998
49
Peyronie's disease is associated with an increase in transforming growth factor-beta protein expression. (9302128)
1997
50
La Peyronie's disease. Our experience]. (2186297)
1990

Variations for Peyronie's Disease

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Expression for genes affiliated with Peyronie's Disease

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Peyronie's Disease

Search GEO for disease gene expression data for Peyronie's Disease.

Pathways for genes affiliated with Peyronie's Disease

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Sources:
51PathCards, 39NCBI BioSystems Database, 55R&D Systems, 61Thomson Reuters, 31KEGG, 58SinoBiological, 52PharmGKB, 56Reactome
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Pathways related to Peyronie's Disease according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5NOS2, IFNA2
2
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
9.5NOS2, IFNA2
39.3TGFB1, NOS2
49.3NOS2, TGFB1
5
Show member pathways
9.3NOS2, TGFB1
69.3MSTN, TGFB1
79.1NOS2, SOD1
89.1SOD1, NOS2
9
Show member pathways
9.1NOS2, SOD1
10
Show member pathways
9.1NOS2, SOD1
11
Show member pathways
9.0SOD1, TGFB1
128.9NOS2, IFNA2, TGFB1
13
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.9TGFB1, IFNA2, NOS2
14
Show member pathways
8.1NOS2, IFNA2, SOD1, TGFB1

Compounds for genes affiliated with Peyronie's Disease

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Sources:
46Novoseek, 12DrugBank, 30IUPHAR, 52PharmGKB, 25HMDB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Peyronie's Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1toremifene46 1210.8IFNA2, TGFB1
2genipin469.8NOS2, TGFB1
33-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide469.7TGFB1, IFNA2
4sildenafil30 46 52 25 1213.7NOS2, TGFB1
5ns 39846 6210.7NOS2, TGFB1
6streptozotocin469.7TGFB1, IFNA2
7erythromycin46 3 52 1212.7IFNA2, TGFB1
8rituximab46 52 1211.6IFNA2, TGFB1
9ang ii469.6NOS2, TGFB1
10bleomycin46 1210.6IFNA2, TGFB1
11allopurinol46 52 1211.6SOD1, IFNA2
12s-nitrosocysteine469.6NOS2, SOD1
13ptio469.6SOD1, NOS2
143-nitrotyrosine469.6NOS2, SOD1
15onoo469.6NOS2, SOD1
16zidovudine46 52 1211.5TGFB1, IFNA2
17ebselen469.5NOS2, SOD1
18n(g)-nitro-l-arginine methyl ester469.5NOS2, SOD1
19ng-nitro-l-arginine469.5NOS2, SOD1
20apocynin46 6210.5SOD1, NOS2
21tetrahydrobiopterin46 25 1211.5SOD1, NOS2
22citrulline46 2510.5NOS2, SOD1
23s-nitroso-n-acetylpenicillamine469.5SOD1, NOS2
24gsno469.5SOD1, NOS2
25nitroglycerin46 1210.5SOD1, NOS2
26polyethylene glycol469.5IFNA2, TGFB1
27alpha lipoic acid469.4NOS2, SOD1
28silymarin469.4NOS2, SOD1
29l-nmma469.4NOS2, SOD1
30peroxynitrite469.4SOD1, NOS2
31carboplatin46 52 1211.3IFNA2, SOD1
32ribonucleic acid469.3IFNA2, MSTN, TGFB1
33doxorubicin46 52 1211.3NOS2, IFNA2, TGFB1
34vitamin-e469.2IFNA2, SOD1
35ascorbic acid46 2510.1SOD1, IFNA2, NOS2
36diethyl dithiocarbamate469.0TGFB1, SOD1, IFNA2
37betacarotene469.0TGFB1, SOD1, IFNA2
38superoxide46 2510.0NOS2, IFNA2, SOD1
39dexamethasone46 52 30 1212.0NOS2, MSTN, TGFB1
40diphenyliodonium469.0NOS2, SOD1, TGFB1
41diphenyleneiodonium469.0NOS2, SOD1, TGFB1
42pdtc468.9NOS2, SOD1, TGFB1
434-hydroxynonenal46 259.9TGFB1, SOD1, NOS2
44sodium nitroprusside468.9NOS2, SOD1, TGFB1
45alpha tocopherol468.9IFNA2, SOD1
46cisplatin46 52 62 1211.9TGFB1, SOD1, IFNA2
47vegf468.8TGFB1, IFNA2, NOS2
48alanine468.6IFNA2, SOD1, TGFB1
49oxygen46 259.6SOD1, MSTN, IFNA2, NOS2
50indomethacin46 30 62 1211.5NOS2, IFNA2, SOD1, TGFB1

GO Terms for genes affiliated with Peyronie's Disease

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17Gene Ontology
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Cellular components related to Peyronie's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peroxisomeGO:0057779.1NOS2, SOD1
2extracellular spaceGO:0056157.8IFNA2, MSTN, SOD1, TGFB1

Biological processes related to Peyronie's Disease according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of gene expressionGO:0106299.6NOS2, IFNA2
2response to hypoxiaGO:0016669.3NOS2, TGFB1
3superoxide metabolic processGO:0068019.3SOD1, NOS2
4response to heatGO:0094089.2SOD1, MSTN
5positive regulation of superoxide anion generationGO:0329309.2SOD1, TGFB1
6platelet degranulationGO:0025769.0SOD1, TGFB1
7transforming growth factor beta receptor signaling pathwayGO:0071799.0MSTN, TGFB1
8response to ethanolGO:0454719.0SOD1, MSTN
9inflammatory responseGO:0069549.0NOS2, IFNA2, TGFB1
10blood coagulationGO:0075968.3NOS2, IFNA2, SOD1, TGFB1

Molecular functions related to Peyronie's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.5IFNA2, MSTN
2growth factor activityGO:0080839.0MSTN, TGFB1
3protein homodimerization activityGO:0428038.5NOS2, SOD1, TGFB1
4protein bindingGO:0055157.4TGFB1, SOD1, MSTN, IFNA2, NOS2

Products for genes affiliated with Peyronie's Disease

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  • Antibodies
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Sources for Peyronie's Disease

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet