MCID: PYR010
MIFTS: 54

Peyronie's Disease malady

Rare diseases, Reproductive diseases categories
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Summaries for Peyronie's Disease

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NIH Rare Diseases:42 Peyronie disease is a connective tissue disorder characterized by a plaque, or hard lump, that forms within the penis. affected individuals may experience painful, curved erections which can make make normal sexual intercourse impossible. symptoms may appear suddenly or develop gradually. while the painful erections for most men resolve over time, the scar tissue and curvature may remain. some cases appear to resolve spontaneously. the exact cause of peyronie's disease is not known. last updated: 11/23/2011

MalaCards based summary: Peyronie's Disease, also known as peyronie disease, is related to hypospadias and gastritis, and has symptoms including An important gene associated with Peyronie's Disease is IFNA2 (interferon, alpha 2), and among its related pathways are Type II interferon signaling (IFNG) and NOD-like Receptor Signaling Pathways. The compounds toremifene and genipin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, endothelial and bone, and related mouse phenotypes are adipose tissue and digestive/alimentary.

Wikipedia:65 Peyronie\'s disease or Peyronie disease (/pe?ro??ni?/), also known as induratio penis plastica (IPP) or... more...

Description from OMIM:46 171000

Aliases & Classifications for Peyronie's Disease

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Sources:
32MalaCards, 8Disease Ontology, 10DISEASES, 62UMLS, 42NIH Rare Diseases, 44Novoseek, 57SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 46OMIM, 25ICD10
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Peyronie's Disease, Aliases & Descriptions:

Name: Peyronie's Disease 32 8
Peyronie Disease 8 42 44 62
Peyronie's Fibromatosis 8 62
Peyronies Disease 32 10
 
Balanitis Xerotica Obliterans 62
Induratio Penis Plastica 8
Penile Curvature 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Reproductive diseases


External Ids:

Disease Ontology8 DOID:8616
NCIt39 C3316
ICD9CM27 607.85
MeSH34 D010411
OMIM46 171000
ICD1025 N48.6

Related Diseases for Peyronie's Disease

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Graphical network of the top 20 diseases related to Peyronie's Disease:



Diseases related to peyronie's disease

Symptoms for Peyronie's Disease

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Clinical features from OMIM:

171000

HPO human phenotypes related to Peyronie's Disease:

id Description Frequency HPO Source Accession
1 abnormality of the genitourinary system HP:0000119
2 abnormality of the skeletal system HP:0000924

Drugs & Therapeutics for Peyronie's Disease

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Drug clinical trials:

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Search NIH Clinical Center for Peyronie's Disease

Genetic Tests for Peyronie's Disease

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Anatomical Context for Peyronie's Disease

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MalaCards organs/tissues related to Peyronie's Disease:

32
Small intestine, Endothelial, Bone, Prostate, Testes, Monocytes

Animal Models for Peyronie's Disease or affiliated genes

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MGI Mouse Phenotypes related to Peyronie's Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.0NOS2, MSTN, TGFB1
2MP:00053818.8NOS2, MSTN, TGFB1
3MP:00053828.7NOS2, MSTN, TGFB1
4MP:00053678.5TGFB1, MSTN, NOS2
5MP:00053708.2NOS2, MSTN, SOD1, TGFB1
6MP:00053698.2TGFB1, SOD1, MSTN, NOS2
7MP:00053858.2TGFB1, SOD1, MSTN, NOS2
8MP:00053868.1TGFB1, SOD1, MSTN, NOS2
9MP:00053878.1NOS2, MSTN, SOD1, TGFB1
10MP:00053848.0TGFB1, SOD1, MSTN, NOS2

Publications for Peyronie's Disease

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Articles related to Peyronie's Disease:

(show top 50)    (show all 528)
idTitleAuthorsYear
1
Re: Penile Corporoplasty with Yachia's Technique for Peyronie's Disease: Single Center Experience with 117 Patients. (24411890)
2014
2
Baseline Characteristics from an Ongoing Phase 3 Study of Collagenase Clostridium Histolyticum in Patients with Peyronie's Disease. (24112401)
2013
3
Surgical therapy of Peyronie's disease by partial plaque excision and grafting with collagen fleece: feasibility study of a new technique. (23446807)
2013
4
Peyronie's disease in Minoan art. (23578389)
2013
5
Penile corporoplasty with Yachia's technique for Peyronie's disease: Single center experience with 117 patients. (24049379)
2013
6
Re: long-term results of the surgical treatment of Peyronie's disease with Egydio's technique: a European multicentre study. (22325532)
2012
7
Update on plication procedures for Peyronie's disease and other penile deformities. (23205060)
2012
8
A new, innovative, lengthening surgical procedure for Peyronie's disease by penile prosthesis implantation with double dorsal-ventral patch graft: the "sliding technique". (22429331)
2012
9
Effectiveness of antioxidants (propolis, blueberry, vitamin E) associated with verapamil in the medical management of Peyronie's disease: a study of 151 cases. (21950543)
2012
10
Peyronie's disease: perspectives on therapeutic targets. (21492024)
2011
11
Re: The Role of Vacuum Pump Therapy to Mechanically Straighten the Penis in Peyronie's Disease. (22088643)
2011
12
Imaging modalities and clinical assesment in men affected with Peyronie's disease. (22802839)
2011
13
Risk factors of Peyronie's disease. What does our clinical experience show? (20955309)
2011
14
Pentoxifylline treatment and penile calcifications in men with Peyronie's disease. (21102473)
2011
15
Inflatable penile prosthesis placement in men with Peyronie's disease and drug-resistant erectile dysfunction: A single-center study. (20722782)
2010
16
Current surgical management of severe peyronie's disease. (21098900)
2010
17
Is there a place for conservative treatment in Peyronie's disease? (19338644)
2009
18
Use of penile extender device in the treatment of penile curvature as a result of Peyronie's disease. Results of a phase II prospective study. (19138361)
2009
19
The effectiveness of transdermal electromotive administration with verapamil and dexamethasone in the treatment of Peyronie's disease. (18592390)
2009
20
Stereological and biochemical analysis of muscular and connective tissue components in the penile corpus cavernosum adjacent to the fibrous plaque of Peyronie's disease. (18782314)
2009
21
Penile traction therapy for treatment of Peyronie's disease: a single-center pilot study. (18373527)
2008
22
The chronology of depression and distress in men with Peyronie's disease. (18554257)
2008
23
Surgical treatment of Peyronie's disease: choosing the best approach to improve patient satisfaction. (18087656)
2008
24
Experience with plaque excision and dermal grafting in the surgical treatment of Peyronie's disease. (18946615)
2008
25
Risk factors for emotional and relationship problems in Peyronie's disease. (18638001)
2008
26
Comparison of vitamin E and propionyl-L-carnitine, separately or in combination, in patients with early chronic Peyronie's disease: a double-blind, placebo controlled, randomized study. (17706714)
2007
27
A Survey of primary-care physicians and urologists regarding Peyronie's disease. (17627727)
2007
28
The natural history of Peyronie's disease. (17601314)
2007
29
Surgical therapy of Peyronie's disease. (18219716)
2006
30
Evaluation of post-operative residual function of corpora cavernosa after soft penile prosthesis implant for Peyronie's disease. (16929602)
2006
31
A critical analysis of nonsurgical treatment of Peyronie's disease. (16698449)
2006
32
The results of plaque incision and venous grafting (Lue procedure) to correct the penile deformity of Peyronie's disease. (15839925)
2005
33
A surgical algorithm for men with combined Peyronie's disease and erectile dysfunction: functional and satisfaction outcomes. (16422916)
2005
34
Alpha-1-antitrypsin levels and genetic variation of the alpha-1-antitrypsin gene in Peyronie's disease. (15474273)
2004
35
Corporoplasty for advanced Peyronie's disease using venous and/or dermis patch grafting: new surgical technique and long-term patient satisfaction. (12576826)
2003
36
Prospective analysis of HLA classes I and II antigen frequency in patients with Peyronie's disease. (14501786)
2003
37
Experience with intraplaque injection of verapamil for Peyronie's disease. (12131321)
2002
38
Peyronie's disease. Who is at risk? (12518211)
2002
39
Management of Peyronie's disease--a review. (11550782)
2001
40
Peyronie's disease in men under age 40: characteristics and outcome. (11313836)
2001
41
Current sexual functioning in 106 patients with Peyronie's disease treated with radiotherapy 9 years earlier. (11113753)
2000
42
The use of betamethasone and hyaluronidase injections in the treatment of Peyronie's disease. (11195899)
2000
43
Microsatellite alterations and loss of heterozygosity in Peyronie's disease. (10953165)
2000
44
Evidence based assessment of long-term results of plaque incision and vein grafting for Peyronie's disease. (10799165)
2000
45
Saphenous vein harvesting by 'stripping' technique and 'W'-shaped patch covering after plaque incision in treatment of Peyronie's disease. (11416831)
2000
46
Tamoxifen versus placebo in the treatment of Peyronie's disease. (10569556)
1999
47
Atypical Peyronie's disease. (10468781)
1999
48
Vein grafting of tunical incisions in the treatment of Peyronie's disease. (10349258)
1998
49
Peyronie's disease is associated with an increase in transforming growth factor-beta protein expression. (9302128)
1997
50
La Peyronie's disease. Our experience]. (2186297)
1990

Variations for Peyronie's Disease

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Expression for genes affiliated with Peyronie's Disease

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Expression patterns in normal tissues for genes affiliated with Peyronie's Disease

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Pathways for genes affiliated with Peyronie's Disease

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Pathways related to Peyronie's Disease according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5NOS2, IFNA2
2
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.5NOS2, IFNA2
39.3TGFB1, NOS2
49.3NOS2, TGFB1
5
Show member pathways
9.3NOS2, TGFB1
69.3MSTN, TGFB1
79.1NOS2, SOD1
89.1SOD1, NOS2
9
Show member pathways
9.1NOS2, SOD1
10
Show member pathways
9.1NOS2, SOD1
11
Show member pathways
9.0SOD1, TGFB1
128.9NOS2, IFNA2, TGFB1
13
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.9TGFB1, IFNA2, NOS2
14
Show member pathways
8.1NOS2, IFNA2, SOD1, TGFB1

Compounds for genes affiliated with Peyronie's Disease

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Compounds related to Peyronie's Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1toremifene44 1110.8IFNA2, TGFB1
2genipin449.8NOS2, TGFB1
33-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.7TGFB1, IFNA2
4sildenafil28 44 50 24 1113.7NOS2, TGFB1
5ns 39844 6110.7NOS2, TGFB1
6streptozotocin449.7TGFB1, IFNA2
7erythromycin44 2 50 1112.7IFNA2, TGFB1
8rituximab44 50 1111.6IFNA2, TGFB1
9ang ii449.6NOS2, TGFB1
10bleomycin44 1110.6IFNA2, TGFB1
11allopurinol44 50 1111.6SOD1, IFNA2
12s-nitrosocysteine449.6NOS2, SOD1
13ptio449.6SOD1, NOS2
143-nitrotyrosine449.6NOS2, SOD1
15onoo449.6NOS2, SOD1
16zidovudine44 50 1111.5TGFB1, IFNA2
17ebselen449.5NOS2, SOD1
18n(g)-nitro-l-arginine methyl ester449.5NOS2, SOD1
19ng-nitro-l-arginine449.5NOS2, SOD1
20apocynin44 6110.5SOD1, NOS2
21tetrahydrobiopterin44 24 1111.5SOD1, NOS2
22citrulline44 2410.5NOS2, SOD1
23s-nitroso-n-acetylpenicillamine449.5SOD1, NOS2
24gsno449.5SOD1, NOS2
25nitroglycerin44 1110.5SOD1, NOS2
26polyethylene glycol449.5IFNA2, TGFB1
27alpha lipoic acid449.4NOS2, SOD1
28silymarin449.4NOS2, SOD1
29l-nmma449.4NOS2, SOD1
30peroxynitrite449.4SOD1, NOS2
31carboplatin44 50 1111.3IFNA2, SOD1
32ribonucleic acid449.3IFNA2, MSTN, TGFB1
33doxorubicin44 50 1111.3NOS2, IFNA2, TGFB1
34vitamin-e449.2IFNA2, SOD1
35ascorbic acid44 2410.1SOD1, IFNA2, NOS2
36diethyl dithiocarbamate449.0TGFB1, SOD1, IFNA2
37betacarotene449.0TGFB1, SOD1, IFNA2
38superoxide44 2410.0NOS2, IFNA2, SOD1
39dexamethasone44 50 28 1112.0NOS2, MSTN, TGFB1
40diphenyliodonium449.0NOS2, SOD1, TGFB1
41diphenyleneiodonium449.0NOS2, SOD1, TGFB1
42pdtc448.9NOS2, SOD1, TGFB1
434-hydroxynonenal44 249.9TGFB1, SOD1, NOS2
44sodium nitroprusside448.9NOS2, SOD1, TGFB1
45alpha tocopherol448.9IFNA2, SOD1
46cisplatin44 50 61 1111.9TGFB1, SOD1, IFNA2
47vegf448.8TGFB1, IFNA2, NOS2
48alanine448.6IFNA2, SOD1, TGFB1
49oxygen44 249.6SOD1, MSTN, IFNA2, NOS2
50indomethacin44 28 61 1111.5NOS2, IFNA2, SOD1, TGFB1

GO Terms for genes affiliated with Peyronie's Disease

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Cellular components related to Peyronie's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peroxisomeGO:0057779.1NOS2, SOD1
2extracellular spaceGO:0056157.8IFNA2, MSTN, SOD1, TGFB1

Biological processes related to Peyronie's Disease according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of gene expressionGO:0106299.6NOS2, IFNA2
2response to hypoxiaGO:0016669.3NOS2, TGFB1
3superoxide metabolic processGO:0068019.3SOD1, NOS2
4response to heatGO:0094089.2SOD1, MSTN
5positive regulation of superoxide anion generationGO:0329309.2SOD1, TGFB1
6platelet degranulationGO:0025769.0SOD1, TGFB1
7transforming growth factor beta receptor signaling pathwayGO:0071799.0MSTN, TGFB1
8response to ethanolGO:0454719.0SOD1, MSTN
9inflammatory responseGO:0069549.0NOS2, IFNA2, TGFB1
10blood coagulationGO:0075968.3NOS2, IFNA2, SOD1, TGFB1

Molecular functions related to Peyronie's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.5MSTN, IFNA2
2growth factor activityGO:0080839.0MSTN, TGFB1
3protein homodimerization activityGO:0428038.5TGFB1, SOD1, NOS2
4protein bindingGO:0055157.4TGFB1, SOD1, MSTN, IFNA2, NOS2

Products for genes affiliated with Peyronie's Disease

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Sources for Peyronie's Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet