MCID: PYR010
MIFTS: 44

Peyronie's Disease malady

Rare diseases, Reproductive diseases categories

Aliases & Classifications for Peyronie's Disease

About this section
Sources:
33MalaCards, 10Disease Ontology, 12DISEASES, 65UMLS, 45NIH Rare Diseases, 47Novoseek, 36MeSH, 59SNOMED-CT, 29ICD9CM, 42NCIt, 27ICD10
See all sources

Aliases & Descriptions for Peyronie's Disease:

Name: Peyronie's Disease 33 10 12
Peyronie Disease 10 45 47 65
Balanitis Xerotica Obliterans 65
Induratio Penis Plastica 10
 
Peyronie's Fibromatosis 10
Peyronies Disease 33
Penile Induration 36
Penile Curvature 45


Classifications:



External Ids:

Disease Ontology10 DOID:8616
ICD9CM29 607.85
NCIt42 C3316
MeSH36 D010411
ICD1027 N48.6

Summaries for Peyronie's Disease

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NIH Rare Diseases:45 Peyronie disease is a connective tissue disorder characterized by a plaque, or hard lump, that forms within the penis. affected individuals may experience painful, curved erections which can make make normal sexual intercourse impossible. symptoms may appear suddenly or develop gradually. while the painful erections for most men resolve over time, the scar tissue and curvature may remain. some cases appear to resolve spontaneously. the exact cause of peyronie's disease is not known. last updated: 11/23/2011

MalaCards based summary: Peyronie's Disease, also known as peyronie disease, is related to hypospadias and familial dupuytren contracture, and has symptoms including abnormality of the genitourinary systemand abnormality of the skeletal system. An important gene associated with Peyronie's Disease is IFNA2 (Interferon, Alpha 2), and among its related pathways are NO-dependent CFTR activation (normal and CF) and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. Affiliated tissues include small intestine, endothelial and monocytes, and related mouse phenotypes are craniofacial and digestive/alimentary.

Wikipedia:68 Peyronie\'s disease or Peyronie disease (/peɪroʊˈniː/), also known as induratio penis plastica (IPP)... more...

Related Diseases for Peyronie's Disease

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Diseases related to Peyronie's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
idRelated DiseaseScoreTop Affiliating Genes
1hypospadias10.7
2familial dupuytren contracture10.2
3pulmonary edema10.2
4priapism10.2
5sjogren's syndrome10.2NOS2, SOD1
6ataxia10.2NOS2, SOD1
7early-onset, autosomal dominant alzheimer disease10.1NOS2, SOD1
8melas syndrome10.1TGFB1, TGFB3
9angina pectoris10.1DCN, NOS2
10premature chromatid separation trait10.1SMAD3, TGFB3
11penis squamous cell carcinoma10.1PDE5A, TGFB1
12thyrotoxic exophthalmos10.1TGFB1, TGFB3
13urinary tract papillary transitional cell benign neoplasm10.1SMAD3, TGFB1
14werner syndrome10.0
15brucellosis10.0
16connective tissue disease10.0
17male reproductive system disease10.0
18penile disease10.0
19reproductive system disease10.0
20sexual disorder10.0
21male genital disorders10.0
22ledderhose disease10.0
23paronychia10.0TGFB1, TGFB3
24antley-bixler syndrome10.0SMAD3, TGFB3
25chronic ulcer of skin10.0SMAD3, TGFB1, TGFB3
26prostate small cell carcinoma10.0DCN, SMAD3, TGFB1
27crouzon syndrome10.0DCN, TGFB1
28pyknoachondrogenesis10.0SMAD7, TGFB1
29vascular hemostatic disease9.9NOS2, SOD1, TGFB3
30protein-energy malnutrition9.9PDE5A, TGFB1
31urethra adenocarcinoma9.9SMAD3, SMAD7, TGFB1
32extrahepatic biliary papillomatosis9.8SMAD3, SMAD7, TGFB1
33hyperandrogenism9.8SMAD3, SMAD7, TGFB3
34keratoconus9.7SMAD3, SMAD7, TGFB1, TGFB3
35nephronophthisis familial adult spastic quadriparesis9.7DCN, SMAD3, SMAD7, TGFB1
36colorectal cancer9.3IFNA2, NOS2, SMAD3, SMAD7, TGFB1, TGFB3
37pulmonary hypertension8.6ACTG2, DCN, IFNA2, NOS2, PDE5A, SMAD3

Graphical network of the top 20 diseases related to Peyronie's Disease:



Diseases related to peyronie's disease

Symptoms for Peyronie's Disease

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HPO human phenotypes related to Peyronie's Disease:

id Description Frequency HPO Source Accession
1 abnormality of the genitourinary system HP:0000119
2 abnormality of the skeletal system HP:0000924

Drugs & Therapeutics for Peyronie's Disease

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Drugs for Peyronie's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
SevelamerapprovedPhase 369152751-57-03085017
Synonyms:
Renagel
Renvela
Sevelamer
Sevelamer Carbonate
 
Sevelamero
Sevelamerum
Sévélamer
sevelamer carbonate
sevelamer hydrochloride
2Botulinum Toxins, Type APhase 2561
3Botulinum ToxinsPhase 2590
4
Testosteroneapproved, investigationalPhase 145358-22-06013
Synonyms:
(+)-testosterone
(+-)-8-iso-testosterone
(+-)-retrotestosterone
(+-)-testosterone
(17b)-17-hydroxy-androst-4-en-3-one
(17beta)-17-Hydroxyandrost-4-en-3-one
(8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
13-Iso-testosterone
17-Hydroxy-(17-beta)-androst-4-en-3-one
17-Hydroxy-(17beta)-androst-4-en-3-one
17-Hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one
17-Hydroxy-D4-androsten-3-one
17-Hydroxy-androst-4-en-3-one
17-beta-Hydroxy-delta(sup 4)-androsten-3-one
17-beta-Hydroxyandrost-4-en-3-one
17?-Hydroxy-4-androsten-3-one
17a-Hydroxy-(13a)-androst-4-en-3-one
17a-Hydroxy-13a-androst-4-en-3-one
17a-Hydroxy-14b-androst-4-en-3-one
17a-Hydroxy-androst-4-en-3-one
17b-Hydroxy-(10a)-androst-4-en-3-one
17b-Hydroxy-(13a)-androst-4-en-3-one
17b-Hydroxy-(8a)-androst-4-en-3-one
17b-Hydroxy-(8a,10a)-androst-4-en-3-one
17b-Hydroxy-(9b)-androst-4-en-3-one
17b-Hydroxy-(9b,10a)-androst-4-en-3-one
17b-Hydroxy-13a-androst-4-en-3-one
17b-Hydroxy-8a-androst-4-en-3-one
17b-Hydroxy-D4-androsten-3-one
17b-Hydroxy-androst-4-en-3-on
17b-Hydroxy-androst-4-en-3-one
17b-Hydroxyandrost-4-en-3-one
17b-Hydroxyandrost-4-ene-3-one
17b-Testosterone
17b-hydroxy-4-androsten-3-one
17beta-Hydroxy-3-oxo-4-androstene
17beta-Hydroxy-4-androsten-3-one
17beta-Hydroxy-delta(sup4)-androsten-3-one
17beta-Hydroxyandrost-4-en-3-one
17beta-Hydroxyandrost-4-ene-3-one
17beta-hydroxy-4-androsten-3-one
4-Androsten-17?-ol-3-one
4-Androsten-17beta-ol-3-one
4-Androsten-3-one-17b-ol
4-androsten-17β-ol-3-one
4-androstene-17beta-ol-3-one
46923_FLUKA
46923_RIEDEL
58-22-0
7-beta-Hydroxyandrost-4-en-3-one
8-Iso-testosterone
9b,10a-Testosterone
9b-Testosterone
AA 2500
AC-14899
AC1L1LM0
Andro 100
AndroGel
Androderm
Androderm (TN)
Androgel
Androgel (TN)
Androlin
Andronaq
Andronate 100
Andronate 200
Andropatch
Andropository 200
Androsorb
Androst-4-en-17b-ol-3-one
Androst-4-en-17beta-ol-3-one
Androst-4-ene-17b-ol-3-one
Andrusol
Andryl 200
Aveed
Axiron
B5DEE83F-632B-48A1-A0ED-A51E7F13DF2E
BIDD:ER0555
BIM-0061761.0001
Bio-0678
C00535
CCRIS 574
CDB 111C
CHEBI:17347
CHEMBL386630
CID6013
CMC_13449
COL 1621
CP 601B
CPD000058344
Cristerona T
Cristerone T
D00075
D4-Androsten-17b-ol-3-one
DB00624
Delatestryl
Depo-Testadiol
Depo-testosterone
Depotest
EINECS 200-370-5
Epitestosteron
Everone 200
Fortesta
Geno-cristaux Gremy
Geno-cristaux gremy
HMS2052N11
HSDB 3398
Halotensin
Homosteron
Homosterone
 
Intrinsa
LMST02020002
LS-148813
LibiGel
Lumitestosteron
MLS000563091
MLS001032098
MLS001306401
MLS002174283
Malerone
Malestrone (amps)
Malogen in Oil
Malogen, aquaspension injection
Mertestate
MolPort-002-506-901
NCGC00091018-01
NSC 9700
Natesto nasal gel
Neo-Hombreol F
Neo-testis
Neotestis
Oreton
Oreton F
Oreton-F
Orquisteron
Perandren
Percutacrine androgenique
Primotest
Primoteston
Rac-17b-hydroxy-(13a)androst-4-en-3-one
Rac-17b-hydroxy-(8a)-androst-4-en-3-one
Rac-17b-hydroxy-(9b,10a)androst-4-en-3-one
Rac-17b-hydroxy-androst-4-en-3-one
Relibra
Retrotestosterone
S00309
S2033_Selleck
SAM001246921
SMR000058344
SMR001261453
Scheinpharm Testone-Cyp
Striant
Striant (TN)
Sustanon
Sustanone
Sustason 250
Synandrol F
T-Cypionate
T1500_SIGMA
T5411_FLUKA
T5411_SIGMA
Teslen
Testamone 100
Testandrone
Testaqua
Testiculosterone
Testim
Testim (TN)
Testobase
Testoderm
Testoderm Tts
Testogel
Testoject-50
Testolent
Testolin
Testopel
Testopel Pellets
Testopropon
Testosteroid
Testosteron
Testosterona
Testosterona [INN-Spanish]
Testosterone
Testosterone (JAN/USP)
Testosterone Enanthate
Testosterone Gel
Testosterone Heptanoate
Testosterone Propionate
Testosterone Undecanoate
Testosterone [Androgenic steroids, anabolic]
Testosterone [INN:BAN]
Testosterone and its esters
Testosterone hydrate
Testosterone solution
Testosteronum
Testosteronum [INN-Latin]
Testostosterone
Testostérone
Testoviron
Testoviron Schering
Testoviron T
Testoxyl
Testred Cypionate 200
Testrin-P.A
Testro AQ
Testrone
Testryl
Tostrelle
Tostrex
UNII-3XMK78S47O
Viatrel
Virilon IM
Virormone
Virosterone
Vogelxo
ZINC06500184
beta testosterone
delta(sup 4)-Androsten-17(beta)-ol-3-one
delta4-Androsten-17beta-ol-3-one
delta4-androsten-17b-ol-3-one
trans-Testosterone
5
MethyltestosteroneapprovedPhase 145358-18-46010
Synonyms:
17(alpha)-Methyl-delta(4)-androsten-17(beta)-ol-3-one
17-Methyltestosterone
17-beta-Hydroxy-17-methylandrost-4-en-3-one
17-methyltestosterone
17alpha-Methyl-3-oxo-4-androsten-17beta-ol
17alpha-Methyl-delta(4)-androsten-17beta-ol-3-one
17alpha-Methyltestosterone
17alpha-methyl-delta-androsten-17beta-ol-3-one
17alpha-methyltestosterone
17beta-Hydroxy-17-methylandrost-4-en-3-one
 
17α-methyl-Δ4-androsten-17β-ol-3-one
17α-methyltestosterone
4-Androstene-17alpha-methyl-17beta-ol-3-one
Android
Methitest
Methyltestosterone
Methyltestosteronum
Metiltestosterona
NSC-9701
Testred
Testred C-III
Virilon
6
Ergocalciferolapproved, nutraceuticalPhase 188550-14-65280793
Synonyms:
'Ergosterol irradiated'
(+)-Vitamin D2
(3-beta,5Z,7E,22E)-9,10-Secoergosta-5,7,10,(19),22-tetraen-3-ol
(3S,5Z,7E,14xi,17alpha,22E)-9,10-secoergosta-5,7,10,22-tetraen-3-ol
(3S,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol
(3S,5Z,7E,22E)-9,10-secoergosta-5,7,10,22-tetraen-3-ol
(3beta,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol
(3beta,5Z,7e,22e)-9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol
(5E,7E,22E)-9,10-Secoergosta-5,7,10,22-tetraen-3-ol
(5Z,7E,22E)-(3S)-9,10-seco-5,7,10(19),22-ergostatetraen-3-ol
(5Z,7E,22E)-(3S)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol
(5Z,7e,22e)-(3S)-9,10-Seco-5,7,10(19),22-ergostatetraen-3-ol
(5Z,7e,22e)-(3S)-9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol
22-Tetraen 3beta 9,10,Secoergosta-5,7,10(19)-ol
31316-19-5
4-Methylene-3-[2-[tetrahydro-7a-methyl-1-(1,4,5-trimethyl-2-hexenyl)-4(3aH)-indanylidene]ethylidene]-Cyclohexanol
47768_SUPELCO
50-14-6
7489-18-1
7E677DC1-E1C4-4FC5-8F4A-BCE1857F7E87
8017-28-5
9,10,Secoergosta-5,7,10(19),22-tetraen 3.beta.-ol
9,10-Seco(5Z,7E,22E)-5,7,10(19),22-ergostatetraen-3-ol
9,10-Secoergosta-5,7,10(19),22-tetraen-3-beta-ol
9,10-Secoergosta-5,7,10(19),22-tetraen-3b-ol
95220_FLUKA
95220_SIGMA
AC-1355
AC1L1FIE
AC1NQXLH
AC1NS4DE
AC1NS9GI
AC1NSSVD
AC1NWAM3
AC1O5EDK
AC1O6WAM
ACon1_002187
Activated ergosterol
BPBio1_000418
BSPBio_000380
BSPBio_001974
Buco-D
C05441
C28H44O
CALCIFEROL IN A GELATIN MATRIX
CALCIFEROL, U.S.P.
CHEBI:28934
CHEMBL1536
CID11003810
CID3249
CID5280793
CID5315257
CID5353610
CID5356615
CID5702050
CID6432478
CID6536972
Calciferol
Calciferol (TN)
Calciferol (vitamin D2)
Calciferolum
Calciferon 2
Condacaps
Condocaps
Condol
Crtron
Crystallina
D-Arthin
D-Tracetten
D00187
DB00153
Daral
Davitamon D
Davitin
De-rat concentrate
Decaps
Dee-Osterol
Dee-Ron
Dee-Ronal
Dee-Roual
Deltalin
Deratol
Detalup
Diactol
Divit urto
Doral
Drisdol
Drisdol (TN)
E5750_SIGMA
EINECS 200-014-9
Ercalciol
Ergocalciferol
Ergocalciferol (D2)
Ergocalciferol (JP15/USP)
Ergocalciferol [INN:BAN:JAN]
Ergocalciferol oil
Ergocalciferol: Vitamin D
 
Ergocalciferolo
Ergocalciferolo [DCIT]
Ergocalciferols
Ergocalciferolum
Ergocalciferolum [INN-Latin]
Ergorone
Ergosterol activated
Ergosterol irradiated
Ergosterol, irradiated
Ertron
Fortodyl
Geltabs
Geltabs Vitamin D
HMS1920K20
HMS2091B19
HMS502I07
HSDB 819
Haliver
Hi-Deratol
Hyperkil
I05-0022
IDI1_000805
Infron
Irradiated ergosta-5,7,22-trien-3-beta-ol
Irradiated ergosta-5,7,22-trien-3.beta.-ol
Irradiated ergosta-5,7,22-trien-3beta-ol
Irradiated ergosterol
LMST03010001
LMST03010014
LS-3228
MEGxm0_000466
MLS001332467
MLS001332468
Metadee
Mina D2
MolPort-001-740-057
MolPort-001-793-930
MolPort-002-526-645
MolPort-003-666-178
MolPort-006-822-629
Mulsiferol
Mykostin
NCGC00142497-01
NCGC00179579-01
NCGC00179579-02
NSC 62792
NSC62792
Novovitamin-D
Oleovitamin D
Oleovitamin D, Synthetic
Oleovitamin D2
Osteil
Ostelin
Prestwick3_000420
Prestwick_554
Radiostol
Radstein
Radsterin
Rodine C
Rodinec
SMR000857106
SPECTRUM1500276
ST057150
STOCK1N-53397
Shock-ferol
Shock-ferol sterogyl
Sorex C.R
Sorex C.R.
Spectrum5_000666
Sterogyl
Synthetic Vitamin D
UNII-VS041H42XC
Uvesterol D
Uvesterol-D
VITAMIN D2
VITAMIN D2 WATER DISPERSABLE U.S.P.
VITAMIN_D2
Vigantol
Vio D
Vio-D
Viostdrol
Viosterol
Viosterol in Oil
Vitamin D
Vitamin D2
Vitamin- D2
Vitamin-?D2
Vitamina D2
Vitavel-D
WLN: L56 FYTJ A1 BY1&1U1Y1&Y1&1 FU2U- BL6YYTJ AU1 DQ
ZINC04474571
ZINC04629876
beta-Ol
bmse000510
component of Geltabs Vitamin D
delta-Arthin
delta-Tracetten
ergocalciferol
vitamin d-2
7
Vitamin Eapproved, nutraceuticalPhase 135059-02-914985
Synonyms:
(+)-a-Tocopherol
(+)-alpha-Tocopherol
(+)-alpha-tocopherol
(+)-α-tocopherol
(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-ol
(2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol
(2R,4'R,8'R)-a-Tocopherol
(2R,4'R,8'R)-alpha-Tocopherol
(2R,4'R,8'r)-alpha-tocopherol
(R,R,R)-a-Tocopherol
(R,R,R)-alpha-Tocopherol
(R,R,R)-alpha-tocopherol
(R,R,R)-α-tocopherol
5,7,8-Trimethyltocol
Amino-Opti-E
Aquasol E
D-alpha-Tocopherol
Daltose
Denamone
E-200 I.U. Softgels
 
E-Complex-600
E-Ferol
E-Vitamin succinate
Eprolin
Gordo-Vite E
Phytogermin
Phytogermine
RRR-alpha-tocopherol
RRR-alpha-tocopheryl
Tocopherol
Vitamin E
Vitamin Ea
Vitamin Plus E Softgells
Vitamin e
Vitec
a-D-Tocopherol
a-Tocopherol
alpha-Tocopherol
alpha-delta-Tocopherol
d-alpha-tocopherol
d-α-tocopherol
delta-alpha-Tocopherol
8TocotrienolsPhase 1352
9TocopherolsPhase 1355
10vitamin dPhase 11463
11
Testosterone enanthatePhase 1453315-37-79416
Synonyms:
17-((1-Oxoheptyl)oxy)androst-4-en-3-one
17-Hydroxyandrost-4-en-3-one, 17-heptanoate
17-Hydroxyandrost-4-en-3-one, 17-heptanoic acid
17beta-Enanthoxyandrost-4-en-3-one
17beta-Hydroxyandrost-4-en-3-one enanthate
4-Androsten-17beta-ol-3-one 17-enanthate
4-Androsten-3-one 17beta-enanthate
Androgyn L.A.
Andropository
Androtardyl
Atlatest
DEA No. 4000
DePatestrye
Delatest
Delatestryl
Depo-Testro Med
Ditate
Durathate
Everone
 
Exten test
Malogen L.A.
Malogen L.A.200
Orquisteron-E
Primotestone
Reposo TMD
Testanthate
Testate
Testenate
Testinon
Testoenant
Testonenant
Testosterone 17-enanthate
Testosterone 17beta-heptanoate
Testosterone 17beta-heptanoic acid
Testosterone enantate
Testosterone heptoate
Testosterone heptoic acid
Testosterone heptylate
Testosterone oenanthate
Testostroval
12ErgocalciferolsPhase 1885
13Testosterone 17 beta-cypionatePhase 1457
14Testosterone undecanoatePhase 1453
15CalciferolNutraceuticalPhase 11028
16TocopherolNutraceuticalPhase 1355
17Vitamin D2NutraceuticalPhase 1885
18TocotrienolNutraceuticalPhase 1352
19Phosphodiesterase 5 Inhibitors518

Interventional clinical trials:

(show all 19)
idNameStatusNCT IDPhase
1Long-term Safety, Curvature Deformity Characterization, and Immunogenicity Over Time in Subjects Previously Treated With AA4500 for Peyronies DiseaseEnrolling by invitationNCT02298829Phase 4
2Study of AA4500 in the Treatment of Peyronie's DiseaseCompletedNCT01221597Phase 3
3A Study of AA4500 in Men With Peyronie's DiseaseCompletedNCT01243411Phase 3
4Study of AA4500 in the Treatment of Peyronie's DiseaseCompletedNCT01221623Phase 3
5A Phase 3, Open-label Study of the Safety and Effectiveness of AA4500 Administered Twice Per Treatment Cycle for up to Four Treatment Cycles (2 x 4) in Men With Peyronie's DiseaseCompletedNCT01685437Phase 3
6An Open-label Study to Assess the Safety and Effectiveness of AA4500 in Combination With the ErecAid® Esteem® Manual Vacuum Therapy System in Treating Men With Peyronie's DiseaseActive, not recruitingNCT02267460Phase 3
7A Randomised, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Sevelamer Carbonate Tablets Dosed Three Times a Day in Hyperphosphataemic Chronic Kidney Disease Patients Not on DialysisTerminatedNCT00833768Phase 3
8The Safety and Effectiveness of AA4500 in Subjects With Peyronie's DiseaseCompletedNCT00755222Phase 2
9Pharmacokinetics of a Single Treatment Cycle of AA4500 0.58 mg in Men With Peyronie's DiseaseCompletedNCT01430169Phase 2
10H-22411: BOTOX® for Peyronie's DiseaseRecruitingNCT00812838Phase 2
11Dupuytren's Disease and Extracorporeal Shockwave Therapy (DupuyShock-2010)RecruitingNCT01184586Phase 2
12Peyronie's Disease Treatment ProtocolCompletedNCT02072018Phase 1
13Evaluate the Safety and Feasibility of Injecting PMD-MSC Into the Penis to Treat the Symptoms of PDCompletedNCT02395029Phase 1
14Testosterone Pellets Plus Vitamin D and E Versus Vitamin D and E Alone for the Treatment of Peyronie's DiseaseActive, not recruitingNCT01578473Phase 1
15Change in Penile Length Following Bilateral Nerve-Sparing Radical ProstatectomyCompletedNCT00800813
16Management of Peyronie's Disease With Adipose Tissue Stem CellRecruitingNCT02414308
17Safety and Clinical Outcomes Study: SVF Deployment for Orthopedic, Neurologic, Urologic, and Cardio-pulmonary ConditionsRecruitingNCT01953523
18Pregnant Women With a Breast Cancer Diagnosed Between 2000 and 2014RecruitingNCT01503034
19Efficacy of Extracorporal Shock Wave Therapy in Patient With Chronic Non-bacterial Prostatitis / Chronic Pelvic Pain SyndromeActive, not recruitingNCT01714830

Search NIH Clinical Center for Peyronie's Disease


Cochrane evidence based reviews: Penile Induration

Genetic Tests for Peyronie's Disease

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Anatomical Context for Peyronie's Disease

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MalaCards organs/tissues related to Peyronie's Disease:

33
Small intestine, Endothelial, Monocytes, Prostate, Bone, Testes

Animal Models for Peyronie's Disease or affiliated genes

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MGI Mouse Phenotypes related to Peyronie's Disease:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.8DCN, NOS2, SMAD3, TGFB1, TGFB3
2MP:00053818.7DCN, NOS2, SMAD3, TGFB1, TGFB3
3MP:00053698.1DCN, NOS2, SMAD7, SOD1, TGFB1
4MP:00053857.7NOS2, SMAD3, SMAD7, SOD1, TGFB1, TGFB3
5MP:00053917.6DCN, NOS2, SMAD3, SOD1, TGFB1, TGFB3
6MP:00053897.6DCN, NOS2, SMAD3, SMAD7, SOD1, TGFB1
7MP:00053847.3DCN, NOS2, SMAD3, SMAD7, SOD1, TGFB1
8MP:00053866.8DCN, NOS2, SMAD3, SMAD7, SOD1, TGFB1

Publications for Peyronie's Disease

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Articles related to Peyronie's Disease:

(show top 50)    (show all 567)
idTitleAuthorsYear
1
PEYRONIE'S DISEASE: A REVIEW OF ETIOLOGY, DIAGNOSIS, AND MANAGEMENT. (26279643)
2015
2
The Effect of Duration of Penile Traction Therapy in Patients Undergoing Intralesional Injection Therapy for Peyronie's Disease. (25804087)
2015
3
Low testosterone has a similar prevalence among men with sexual dysfunction due to either Peyronie's disease or erectile dysfunction and does not correlate with Peyronie's disease severity. (25580982)
2015
4
Re: Penile Corporoplasty with Yachia's Technique for Peyronie's Disease: Single Center Experience with 117 Patients. (24411890)
2014
5
Psychosexual Symptoms and Treatment of Peyronie's Disease Within a Collaborative Care Model. (25548648)
2014
6
Baseline Characteristics from an Ongoing Phase 3 Study of Collagenase Clostridium Histolyticum in Patients with Peyronie's Disease. (24112401)
2013
7
Surgical therapy of Peyronie's disease by partial plaque excision and grafting with collagen fleece: feasibility study of a new technique. (23446807)
2013
8
Peyronie's disease in Minoan art. (23578389)
2013
9
Penile corporoplasty with Yachia's technique for Peyronie's disease: Single center experience with 117 patients. (24049379)
2013
10
Re: long-term results of the surgical treatment of Peyronie's disease with Egydio's technique: a European multicentre study. (22325532)
2012
11
Update on plication procedures for Peyronie's disease and other penile deformities. (23205060)
2012
12
A new, innovative, lengthening surgical procedure for Peyronie's disease by penile prosthesis implantation with double dorsal-ventral patch graft: the "sliding technique". (22429331)
2012
13
Effectiveness of antioxidants (propolis, blueberry, vitamin E) associated with verapamil in the medical management of Peyronie's disease: a study of 151 cases. (21950543)
2012
14
Peyronie's disease: perspectives on therapeutic targets. (21492024)
2011
15
Re: The Role of Vacuum Pump Therapy to Mechanically Straighten the Penis in Peyronie's Disease. (22088643)
2011
16
Imaging modalities and clinical assesment in men affected with Peyronie's disease. (22802839)
2011
17
Risk factors of Peyronie's disease. What does our clinical experience show? (20955309)
2011
18
Pentoxifylline treatment and penile calcifications in men with Peyronie's disease. (21102473)
2011
19
Inflatable penile prosthesis placement in men with Peyronie's disease and drug-resistant erectile dysfunction: A single-center study. (20722782)
2010
20
Current surgical management of severe peyronie's disease. (21098900)
2010
21
Is there a place for conservative treatment in Peyronie's disease? (19338644)
2009
22
Use of penile extender device in the treatment of penile curvature as a result of Peyronie's disease. Results of a phase II prospective study. (19138361)
2009
23
The effectiveness of transdermal electromotive administration with verapamil and dexamethasone in the treatment of Peyronie's disease. (18592390)
2009
24
Stereological and biochemical analysis of muscular and connective tissue components in the penile corpus cavernosum adjacent to the fibrous plaque of Peyronie's disease. (18782314)
2009
25
Penile traction therapy for treatment of Peyronie's disease: a single-center pilot study. (18373527)
2008
26
The chronology of depression and distress in men with Peyronie's disease. (18554257)
2008
27
Surgical treatment of Peyronie's disease: choosing the best approach to improve patient satisfaction. (18087656)
2008
28
Experience with plaque excision and dermal grafting in the surgical treatment of Peyronie's disease. (18946615)
2008
29
Risk factors for emotional and relationship problems in Peyronie's disease. (18638001)
2008
30
Comparison of vitamin E and propionyl-L-carnitine, separately or in combination, in patients with early chronic Peyronie's disease: a double-blind, placebo controlled, randomized study. (17706714)
2007
31
A Survey of primary-care physicians and urologists regarding Peyronie's disease. (17627727)
2007
32
The natural history of Peyronie's disease. (17601314)
2007
33
Surgical therapy of Peyronie's disease. (18219716)
2006
34
Evaluation of post-operative residual function of corpora cavernosa after soft penile prosthesis implant for Peyronie's disease. (16929602)
2006
35
A critical analysis of nonsurgical treatment of Peyronie's disease. (16698449)
2006
36
The results of plaque incision and venous grafting (Lue procedure) to correct the penile deformity of Peyronie's disease. (15839925)
2005
37
Alpha-1-antitrypsin levels and genetic variation of the alpha-1-antitrypsin gene in Peyronie's disease. (15474273)
2004
38
Corporoplasty for advanced Peyronie's disease using venous and/or dermis patch grafting: new surgical technique and long-term patient satisfaction. (12576826)
2003
39
Prospective analysis of HLA classes I and II antigen frequency in patients with Peyronie's disease. (14501786)
2003
40
Experience with intraplaque injection of verapamil for Peyronie's disease. (12131321)
2002
41
Management of Peyronie's disease--a review. (11550782)
2001
42
Peyronie's disease in men under age 40: characteristics and outcome. (11313836)
2001
43
Current sexual functioning in 106 patients with Peyronie's disease treated with radiotherapy 9 years earlier. (11113753)
2000
44
The use of betamethasone and hyaluronidase injections in the treatment of Peyronie's disease. (11195899)
2000
45
Microsatellite alterations and loss of heterozygosity in Peyronie's disease. (10953165)
2000
46
Evidence based assessment of long-term results of plaque incision and vein grafting for Peyronie's disease. (10799165)
2000
47
Saphenous vein harvesting by 'stripping' technique and 'W'-shaped patch covering after plaque incision in treatment of Peyronie's disease. (11416831)
2000
48
Tamoxifen versus placebo in the treatment of Peyronie's disease. (10569556)
1999
49
Peyronie's disease is associated with an increase in transforming growth factor-beta protein expression. (9302128)
1997
50
La Peyronie's disease. Our experience]. (2186297)
1990

Variations for Peyronie's Disease

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Expression for genes affiliated with Peyronie's Disease

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Search GEO for disease gene expression data for Peyronie's Disease.

Pathways for genes affiliated with Peyronie's Disease

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Pathways related to Peyronie's Disease according to GeneCards Suite gene sharing:

(show all 37)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7NOS2, PDE5A
29.7TGFB1, TGFB3
39.7TGFB1, TGFB3
4
Show member pathways
9.7TGFB1, TGFB3
59.7TGFB1, TGFB3
6
Show member pathways
9.4NOS2, TGFB1, TGFB3
79.4NOS2, TGFB1, TGFB3
8
Show member pathways
9.3SMAD3, TGFB1, TGFB3
99.3SMAD3, TGFB1, TGFB3
10
Show member pathways
9.3SMAD3, TGFB1, TGFB3
11
Show member pathways
9.3SMAD3, TGFB1, TGFB3
12
Show member pathways
9.3SMAD3, TGFB1, TGFB3
13
Show member pathways
9.3SMAD3, TGFB1, TGFB3
149.3SMAD3, TGFB1, TGFB3
159.3SMAD3, SMAD7, TGFB1
169.3SMAD3, SMAD7, TGFB1
17
Show member pathways
9.3SMAD3, SMAD7, TGFB1
18
Show member pathways
9.3SMAD3, SMAD7, TGFB1
199.2DCN, TGFB1, TGFB3
20
Show member pathways
9.2SMAD7, TGFB1, TGFB3
219.1IFNA2, NOS2, TGFB1, TGFB3
22
Show member pathways
9.0IFNA2, SMAD3, TGFB1, TGFB3
239.0NOS2, SMAD3, TGFB1, TGFB3
249.0NOS2, SMAD3, TGFB1, TGFB3
258.9NOS2, SMAD3, SOD1
26
Show member pathways
8.9SOD1, TGFB1, TGFB3
27
TGF-beta Signaling Pathway (sino)
Show member pathways
8.8SOD1, TGFB1, TGFB3
28
Show member pathways
8.8SMAD3, SMAD7, TGFB1, TGFB3
298.8SMAD3, SMAD7, TGFB1, TGFB3
308.8SMAD3, SMAD7, TGFB1, TGFB3
318.8SMAD3, SMAD7, TGFB1, TGFB3
328.8SMAD3, SMAD7, TGFB1, TGFB3
33
Show member pathways
8.7ACTG2, NOS2, TGFB1, TGFB3
34
Show member pathways
8.7IFNA2, NOS2, SMAD3, TGFB1, TGFB3
35
TGF-beta signaling pathway (KEGG)
Show member pathways
8.3IFNA2, NOS2, SMAD3, TGFB1, TGFB3
368.2ACTG2, SMAD3, SMAD7, TGFB1, TGFB3
37
Show member pathways
7.8IFNA2, NOS2, PDE5A, SOD1, TGFB1, TGFB3

GO Terms for genes affiliated with Peyronie's Disease

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Cellular components related to Peyronie's Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:00301419.2SOD1, TGFB1, TGFB3
2extracellular matrixGO:00310128.4DCN, SOD1, TGFB3
3extracellular spaceGO:00056157.4ACTG2, DCN, IFNA2, SOD1, TGFB1, TGFB3

Biological processes related to Peyronie's Disease according to GeneCards Suite gene sharing:

(show all 46)
idNameGO IDScoreTop Affiliating Genes
1evasion or tolerance of host defenses by virusGO:001904910.5SMAD3, TGFB1
2regulation of bindingGO:005109810.5SMAD3, TGFB1
3positive regulation of extracellular matrix assemblyGO:190120310.5SMAD3, TGFB1
4SMAD protein complex assemblyGO:000718310.5SMAD3, TGFB1
5regulation of striated muscle tissue developmentGO:001620210.5SMAD3, TGFB1
6endoderm developmentGO:000749210.4SMAD3, TGFB1
7frontal suture morphogenesisGO:006036410.4TGFB1, TGFB3
8positive regulation of collagen biosynthetic processGO:003296710.3TGFB1, TGFB3
9negative regulation of protein catabolic processGO:004217710.3NOS2, SMAD3
10SMAD protein import into nucleusGO:000718410.3TGFB1, TGFB3
11negative regulation of macrophage cytokine productionGO:001093610.3TGFB1, TGFB3
12positive regulation of SMAD protein import into nucleusGO:006039110.3TGFB1, TGFB3
13positive regulation of protein secretionGO:005071410.3TGFB1, TGFB3
14negative regulation of T cell proliferationGO:004213010.3PDE5A, TGFB1
15salivary gland morphogenesisGO:000743510.3TGFB1, TGFB3
16mammary gland developmentGO:003087910.3TGFB1, TGFB3
17growthGO:004000710.3TGFB1, TGFB3
18response to progesteroneGO:003257010.2TGFB1, TGFB3
19lens fiber cell differentiationGO:007030610.2SMAD3, TGFB1
20negative regulation of DNA replicationGO:000815610.2TGFB1, TGFB3
21pathway-restricted SMAD protein phosphorylationGO:006038910.2SMAD7, TGFB1
22face morphogenesisGO:006032510.2TGFB1, TGFB3
23ossification involved in bone remodelingGO:004393210.1TGFB1, TGFB3
24digestive tract developmentGO:004856510.0TGFB1, TGFB3
25negative regulation of gene expressionGO:00106299.9IFNA2, NOS2, TGFB1
26positive regulation of epithelial to mesenchymal transitionGO:00107189.9SMAD3, TGFB1, TGFB3
27regulation of transforming growth factor beta receptor signaling pathwayGO:00170159.9SMAD3, SMAD7, TGFB1
28positive regulation of bone mineralizationGO:00305019.9SMAD3, TGFB1, TGFB3
29response to laminar fluid shear stressGO:00346169.8SMAD7, TGFB1, TGFB3
30SMAD protein signal transductionGO:00603959.8SMAD3, TGFB1, TGFB3
31negative regulation of mitotic cell cycleGO:00459309.8SMAD3, TGFB1
32cell-cell junction organizationGO:00452169.8SMAD3, TGFB1, TGFB3
33positive regulation of superoxide anion generationGO:00329309.7SOD1, TGFB1
34superoxide metabolic processGO:00068019.7NOS2, SOD1
35ureteric bud developmentGO:00016579.7SMAD3, SMAD7, TGFB1
36regulation of cell proliferationGO:00421279.7NOS2, TGFB1, TGFB3
37placenta developmentGO:00018909.6DCN, SOD1
38positive regulation of transcription, DNA-templatedGO:00458939.4IFNA2, SMAD3, TGFB1, TGFB3
39platelet degranulationGO:00025769.4SOD1, TGFB1, TGFB3
40response to hypoxiaGO:00016669.3NOS2, SMAD3, TGFB1, TGFB3
41negative regulation of transforming growth factor beta receptor signaling pathwayGO:00305129.3SMAD3, SMAD7, TGFB1, TGFB3
42transforming growth factor beta receptor signaling pathwayGO:00071799.1SMAD3, SMAD7, TGFB1, TGFB3
43wound healingGO:00420609.1DCN, SMAD3, TGFB1, TGFB3
44agingGO:00075688.7DCN, SOD1, TGFB1, TGFB3
45platelet activationGO:00301688.6SOD1, TGFB1, TGFB3
46blood coagulationGO:00075967.7IFNA2, NOS2, PDE5A, SOD1, TGFB1, TGFB3

Molecular functions related to Peyronie's Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1type III transforming growth factor beta receptor bindingGO:003471410.1TGFB1, TGFB3
2type II transforming growth factor beta receptor bindingGO:000511410.1TGFB1, TGFB3
3type I transforming growth factor beta receptor bindingGO:00347139.6SMAD7, TGFB1, TGFB3
4cytokine activityGO:00051259.1IFNA2, TGFB1, TGFB3
5collagen bindingGO:00055189.1DCN, SMAD3, SMAD7

Sources for Peyronie's Disease

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet