MCID: PYR010
MIFTS: 47

Peyronie's Disease malady

Rare diseases, Reproductive diseases categories

Aliases & Classifications for Peyronie's Disease

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Sources:
31MalaCards, 9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 27ICD9CM, 38NCIt, 33MeSH, 25ICD10
See all sources

Peyronie's Disease, Aliases & Descriptions:

Name: Peyronie's Disease 31 9
Peyronie Disease 9 41 43 60
Peyronies Disease 31 11
Balanitis Xerotica Obliterans 60
 
Induratio Penis Plastica 9
Peyronie's Fibromatosis 9
Penile Curvature 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Reproductive diseases


External Ids:

Disease Ontology9 DOID:8616
ICD9CM27 607.85
NCIt38 C3316
MeSH33 D010411
ICD1025 N48.6

Summaries for Peyronie's Disease

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NIH Rare Diseases:41 Peyronie disease is a connective tissue disorder characterized by a plaque, or hard lump, that forms within the penis. affected individuals may experience painful, curved erections which can make make normal sexual intercourse impossible. symptoms may appear suddenly or develop gradually. while the painful erections for most men resolve over time, the scar tissue and curvature may remain. some cases appear to resolve spontaneously. the exact cause of peyronie's disease is not known. last updated: 11/23/2011

MalaCards based summary: Peyronie's Disease, also known as peyronie disease, is related to hypospadias and gastritis, and has symptoms including abnormality of the genitourinary systemand abnormality of the skeletal system. An important gene associated with Peyronie's Disease is IFNA2 (interferon, alpha 2), and among its related pathways are Type II interferon signaling (IFNG) and NOD-like Receptor Signaling Pathways. The compounds toremifene and genipin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, endothelial and bone, and related mouse phenotypes are adipose tissue and digestive/alimentary.

Wikipedia:63 Peyronie\'s disease or Peyronie disease (/pe?ro??ni?/), also known as induratio penis plastica (IPP) or... more...

Related Diseases for Peyronie's Disease

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Graphical network of the top 20 diseases related to Peyronie's Disease:



Diseases related to peyronie's disease

Symptoms for Peyronie's Disease

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HPO human phenotypes related to Peyronie's Disease:

id Description Frequency HPO Source Accession
1 abnormality of the genitourinary system HP:0000119
2 abnormality of the skeletal system HP:0000924

Drugs & Therapeutics for Peyronie's Disease

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Drug clinical trials:

Search ClinicalTrials for Peyronie's Disease

Search NIH Clinical Center for Peyronie's Disease

Genetic Tests for Peyronie's Disease

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Anatomical Context for Peyronie's Disease

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MalaCards organs/tissues related to Peyronie's Disease:

31
Small intestine, Endothelial, Bone, Prostate, Testes, Monocytes

Animal Models for Peyronie's Disease or affiliated genes

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MGI Mouse Phenotypes related to Peyronie's Disease:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.0NOS2, MSTN, TGFB1
2MP:00053818.8NOS2, MSTN, TGFB1
3MP:00053828.7NOS2, MSTN, TGFB1
4MP:00053678.5TGFB1, MSTN, NOS2
5MP:00053708.2NOS2, MSTN, SOD1, TGFB1
6MP:00053698.2TGFB1, SOD1, MSTN, NOS2
7MP:00053858.2TGFB1, SOD1, MSTN, NOS2
8MP:00053868.1TGFB1, SOD1, MSTN, NOS2
9MP:00053878.1NOS2, MSTN, SOD1, TGFB1
10MP:00053848.0TGFB1, SOD1, MSTN, NOS2

Publications for Peyronie's Disease

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Articles related to Peyronie's Disease:

(show top 50)    (show all 545)
idTitleAuthorsYear
1
The Effect of Duration of Penile Traction Therapy in Patients Undergoing Intralesional Injection Therapy for Peyronie's Disease. (25804087)
2015
2
Low testosterone has a similar prevalence among men with sexual dysfunction due to either Peyronie's disease or erectile dysfunction and does not correlate with Peyronie's disease severity. (25580982)
2015
3
Re: Penile Corporoplasty with Yachia's Technique for Peyronie's Disease: Single Center Experience with 117 Patients. (24411890)
2014
4
Psychosexual Symptoms and Treatment of Peyronie's Disease Within a Collaborative Care Model. (25548648)
2014
5
Baseline Characteristics from an Ongoing Phase 3 Study of Collagenase Clostridium Histolyticum in Patients with Peyronie's Disease. (24112401)
2013
6
Surgical therapy of Peyronie's disease by partial plaque excision and grafting with collagen fleece: feasibility study of a new technique. (23446807)
2013
7
Peyronie's disease in Minoan art. (23578389)
2013
8
Penile corporoplasty with Yachia's technique for Peyronie's disease: Single center experience with 117 patients. (24049379)
2013
9
Re: long-term results of the surgical treatment of Peyronie's disease with Egydio's technique: a European multicentre study. (22325532)
2012
10
Update on plication procedures for Peyronie's disease and other penile deformities. (23205060)
2012
11
A new, innovative, lengthening surgical procedure for Peyronie's disease by penile prosthesis implantation with double dorsal-ventral patch graft: the "sliding technique". (22429331)
2012
12
Effectiveness of antioxidants (propolis, blueberry, vitamin E) associated with verapamil in the medical management of Peyronie's disease: a study of 151 cases. (21950543)
2012
13
Peyronie's disease: perspectives on therapeutic targets. (21492024)
2011
14
Re: The Role of Vacuum Pump Therapy to Mechanically Straighten the Penis in Peyronie's Disease. (22088643)
2011
15
Imaging modalities and clinical assesment in men affected with Peyronie's disease. (22802839)
2011
16
Risk factors of Peyronie's disease. What does our clinical experience show? (20955309)
2011
17
Pentoxifylline treatment and penile calcifications in men with Peyronie's disease. (21102473)
2011
18
Inflatable penile prosthesis placement in men with Peyronie's disease and drug-resistant erectile dysfunction: A single-center study. (20722782)
2010
19
Current surgical management of severe peyronie's disease. (21098900)
2010
20
Is there a place for conservative treatment in Peyronie's disease? (19338644)
2009
21
Use of penile extender device in the treatment of penile curvature as a result of Peyronie's disease. Results of a phase II prospective study. (19138361)
2009
22
The effectiveness of transdermal electromotive administration with verapamil and dexamethasone in the treatment of Peyronie's disease. (18592390)
2009
23
Stereological and biochemical analysis of muscular and connective tissue components in the penile corpus cavernosum adjacent to the fibrous plaque of Peyronie's disease. (18782314)
2009
24
Penile traction therapy for treatment of Peyronie's disease: a single-center pilot study. (18373527)
2008
25
The chronology of depression and distress in men with Peyronie's disease. (18554257)
2008
26
Surgical treatment of Peyronie's disease: choosing the best approach to improve patient satisfaction. (18087656)
2008
27
Experience with plaque excision and dermal grafting in the surgical treatment of Peyronie's disease. (18946615)
2008
28
Risk factors for emotional and relationship problems in Peyronie's disease. (18638001)
2008
29
Comparison of vitamin E and propionyl-L-carnitine, separately or in combination, in patients with early chronic Peyronie's disease: a double-blind, placebo controlled, randomized study. (17706714)
2007
30
A Survey of primary-care physicians and urologists regarding Peyronie's disease. (17627727)
2007
31
The natural history of Peyronie's disease. (17601314)
2007
32
Surgical therapy of Peyronie's disease. (18219716)
2006
33
Evaluation of post-operative residual function of corpora cavernosa after soft penile prosthesis implant for Peyronie's disease. (16929602)
2006
34
A critical analysis of nonsurgical treatment of Peyronie's disease. (16698449)
2006
35
The results of plaque incision and venous grafting (Lue procedure) to correct the penile deformity of Peyronie's disease. (15839925)
2005
36
A surgical algorithm for men with combined Peyronie's disease and erectile dysfunction: functional and satisfaction outcomes. (16422916)
2005
37
Alpha-1-antitrypsin levels and genetic variation of the alpha-1-antitrypsin gene in Peyronie's disease. (15474273)
2004
38
Corporoplasty for advanced Peyronie's disease using venous and/or dermis patch grafting: new surgical technique and long-term patient satisfaction. (12576826)
2003
39
Prospective analysis of HLA classes I and II antigen frequency in patients with Peyronie's disease. (14501786)
2003
40
Experience with intraplaque injection of verapamil for Peyronie's disease. (12131321)
2002
41
Management of Peyronie's disease--a review. (11550782)
2001
42
Peyronie's disease in men under age 40: characteristics and outcome. (11313836)
2001
43
Current sexual functioning in 106 patients with Peyronie's disease treated with radiotherapy 9 years earlier. (11113753)
2000
44
The use of betamethasone and hyaluronidase injections in the treatment of Peyronie's disease. (11195899)
2000
45
Microsatellite alterations and loss of heterozygosity in Peyronie's disease. (10953165)
2000
46
Evidence based assessment of long-term results of plaque incision and vein grafting for Peyronie's disease. (10799165)
2000
47
Saphenous vein harvesting by 'stripping' technique and 'W'-shaped patch covering after plaque incision in treatment of Peyronie's disease. (11416831)
2000
48
Tamoxifen versus placebo in the treatment of Peyronie's disease. (10569556)
1999
49
Peyronie's disease is associated with an increase in transforming growth factor-beta protein expression. (9302128)
1997
50
La Peyronie's disease. Our experience]. (2186297)
1990

Variations for Peyronie's Disease

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Expression for genes affiliated with Peyronie's Disease

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Search GEO for disease gene expression data for Peyronie's Disease.

Pathways for genes affiliated with Peyronie's Disease

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Pathways related to Peyronie's Disease according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5NOS2, IFNA2
2
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
9.5NOS2, IFNA2
39.3TGFB1, NOS2
49.3NOS2, TGFB1
5
Show member pathways
9.3NOS2, TGFB1
69.3MSTN, TGFB1
79.1NOS2, SOD1
89.1SOD1, NOS2
9
Show member pathways
9.1NOS2, SOD1
10
Show member pathways
9.1NOS2, SOD1
11
Show member pathways
9.0SOD1, TGFB1
128.9NOS2, IFNA2, TGFB1
13
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.9TGFB1, IFNA2, NOS2
14
Show member pathways
8.1NOS2, IFNA2, SOD1, TGFB1

Compounds for genes affiliated with Peyronie's Disease

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Compounds related to Peyronie's Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1toremifene43 1210.8IFNA2, TGFB1
2genipin439.8NOS2, TGFB1
33-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide439.7TGFB1, IFNA2
4sildenafil28 43 49 24 1213.7NOS2, TGFB1
5ns 39843 5910.7NOS2, TGFB1
6streptozotocin439.7TGFB1, IFNA2
7erythromycin43 2 49 1212.7IFNA2, TGFB1
8rituximab43 49 1211.6IFNA2, TGFB1
9ang ii439.6NOS2, TGFB1
10bleomycin43 1210.6IFNA2, TGFB1
11allopurinol43 49 1211.6SOD1, IFNA2
12s-nitrosocysteine439.6NOS2, SOD1
13ptio439.6SOD1, NOS2
143-nitrotyrosine439.6NOS2, SOD1
15onoo439.6NOS2, SOD1
16zidovudine43 49 1211.5TGFB1, IFNA2
17ebselen439.5NOS2, SOD1
18n(g)-nitro-l-arginine methyl ester439.5NOS2, SOD1
19ng-nitro-l-arginine439.5NOS2, SOD1
20apocynin43 5910.5SOD1, NOS2
21tetrahydrobiopterin43 24 1211.5SOD1, NOS2
22citrulline43 2410.5NOS2, SOD1
23s-nitroso-n-acetylpenicillamine439.5SOD1, NOS2
24gsno439.5SOD1, NOS2
25nitroglycerin43 1210.5SOD1, NOS2
26polyethylene glycol439.5IFNA2, TGFB1
27alpha lipoic acid439.4NOS2, SOD1
28silymarin439.4NOS2, SOD1
29l-nmma439.4NOS2, SOD1
30peroxynitrite439.4SOD1, NOS2
31carboplatin43 49 1211.3IFNA2, SOD1
32ribonucleic acid439.3IFNA2, MSTN, TGFB1
33doxorubicin43 49 1211.3NOS2, IFNA2, TGFB1
34vitamin-e439.2IFNA2, SOD1
35ascorbic acid43 2410.1SOD1, IFNA2, NOS2
36diethyl dithiocarbamate439.0TGFB1, SOD1, IFNA2
37betacarotene439.0TGFB1, SOD1, IFNA2
38superoxide43 2410.0NOS2, IFNA2, SOD1
39dexamethasone43 49 28 1212.0NOS2, MSTN, TGFB1
40diphenyliodonium439.0NOS2, SOD1, TGFB1
41diphenyleneiodonium439.0NOS2, SOD1, TGFB1
42pdtc438.9NOS2, SOD1, TGFB1
434-hydroxynonenal43 249.9TGFB1, SOD1, NOS2
44sodium nitroprusside438.9NOS2, SOD1, TGFB1
45alpha tocopherol438.9IFNA2, SOD1
46cisplatin43 49 59 1211.9TGFB1, SOD1, IFNA2
47vegf438.8TGFB1, IFNA2, NOS2
48alanine438.6IFNA2, SOD1, TGFB1
49oxygen43 249.6SOD1, MSTN, IFNA2, NOS2
50indomethacin43 28 59 1211.5NOS2, IFNA2, SOD1, TGFB1

GO Terms for genes affiliated with Peyronie's Disease

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Cellular components related to Peyronie's Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peroxisomeGO:00057779.1NOS2, SOD1
2extracellular spaceGO:00056157.8IFNA2, MSTN, SOD1, TGFB1

Biological processes related to Peyronie's Disease according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of gene expressionGO:00106299.6NOS2, IFNA2
2response to hypoxiaGO:00016669.3NOS2, TGFB1
3superoxide metabolic processGO:00068019.3SOD1, NOS2
4response to heatGO:00094089.2SOD1, MSTN
5positive regulation of superoxide anion generationGO:00329309.2SOD1, TGFB1
6platelet degranulationGO:00025769.0SOD1, TGFB1
7transforming growth factor beta receptor signaling pathwayGO:00071799.0MSTN, TGFB1
8response to ethanolGO:00454719.0SOD1, MSTN
9inflammatory responseGO:00069549.0NOS2, IFNA2, TGFB1
10blood coagulationGO:00075968.3NOS2, IFNA2, SOD1, TGFB1

Molecular functions related to Peyronie's Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.5IFNA2, MSTN
2growth factor activityGO:00080839.0MSTN, TGFB1
3protein homodimerization activityGO:00428038.5NOS2, SOD1, TGFB1
4protein bindingGO:00055157.4TGFB1, SOD1, MSTN, IFNA2, NOS2

Products for genes affiliated with Peyronie's Disease

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Sources for Peyronie's Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet