MCID: PYR026
MIFTS: 26

Peyronies Disease malady

Summaries for Peyronies Disease

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33MalaCards
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MalaCards: Peyronies Disease is related to peyronie's disease and plantar fascial fibromatosis. An important gene associated with Peyronies Disease is IFNA2 (interferon, alpha 2), and among its related pathways are TGF-beta Signaling Pathway and NO-dependent CFTR activation (normal and CF). The compounds estrogen and indomethacin have been mentioned in the context of this disorder. Related mouse phenotypes are skeleton and reproductive system.

Aliases & Classifications for Peyronies Disease

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10DISEASES
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Aliases & Descriptions:

peyronies disease 10


Related Diseases for Peyronies Disease

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Peyronies Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 152)
idRelated DiseaseScoreTop Affiliating Genes
1peyronie's disease30.6NOS2, TGFB1, SOD1, IFNA2, PDE5A
2plantar fascial fibromatosis10.1
3familial dupuytren contracture10.1
4lung cancer10.0TGFB1
5prostatitis10.0PDE5A
6rhinitis10.0PDE5A
7myeloma10.0IFNA2
8vitiligo10.0SOD1
9deficiency anemia10.0IFNA2
10neuropathy10.0MSTN
11bronchopulmonary dysplasia10.0SOD1
12coronary heart disease10.0PDE5A
13essential hypertension10.0SOD1
14myopathy10.0MSTN
15kidney cancer10.0IFNA2
16pneumoconiosis10.0SOD1
17hypercholesterolemia10.0NOS2
18gastritis10.0NOS2
19priapism10.0PDE5A
20biliary atresia10.0TGFB1
21skin disease10.0TGFB1
22migraine10.0PDE5A
23fibrosarcoma10.0TGFB1
24hepatopulmonary syndrome10.0HMOX1
25polyneuropathy10.0IFNA2
26alpha 1-antitrypsin deficiency10.0SERPINA1
27acute myocardial infarction10.0SERPINA1
28malaria10.0HLA-A
29ureteral obstruction10.0TGFB1
30diabetic retinopathy10.0SOD1, NOS2
31lichen planus10.0IFNA2
32nephritis10.0CCL2
33kawasaki disease10.0CCL2
34bronchiectasis10.0SERPINA1
35peritonitis10.0CCL2
36amyloidosis10.0DCN
37cryoglobulinemia10.0IFNA2
38ankylosing spondylitis10.0HLA-A
39dyspepsia10.0PDE5A
40celiac disease10.0HLA-A
41wilms tumor10.0PTN
42laryngeal carcinoma10.0HLA-A
43meningioma10.0PTN
44allergic rhinitis10.0PDE4A
45proliferative diabetic retinopathy10.0CCL2
46myocarditis10.0NOS2
47galactosemia10.0SERPINA1, TGFB1
48nephrotic syndrome10.0SERPINA1, HLA-S
49myelodysplastic syndromes10.0PDE4A
50viral hepatitis10.0IFNA2, SERPINA1

Graphical network of the top 20 diseases related to Peyronies Disease:



Diseases related to peyronies disease

Clinical Features for Peyronies Disease

Drugs & Therapeutics for Peyronies Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Peyronies Disease

Drug clinical trials:

Search ClinicalTrials for Peyronies Disease

Search NIH Clinical Center for Peyronies Disease

Search CenterWatch for Peyronies Disease

Genetic Tests for Peyronies Disease

Anatomical Context for Peyronies Disease

Animal Models for Peyronies Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Peyronies Disease

Genetic Variations for Peyronies Disease

Expression for genes affiliated with Peyronies Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Peyronies Disease

Search GEO for disease gene expression data for Peyronies Disease.

Pathways for genes affiliated with Peyronies Disease

Sources:
56SinoBiological, 54Reactome, 38NCBI BioSystems Database, 30KEGG, 52QIAGEN
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Pathways related to Peyronies Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1MSTN, DCN
2
NO-dependent CFTR activation (normal and CF)
10.1NOS2, PDE5A
3
Hide members
10.0TGFB1, SOD1, SERPINA1
49.8CCL2, DCN, HMOX1
59.7DCN, TGFB1, BMP6
6
Hide members
9.2CCL2, IFNA2, BMP6, PTN, TGFB1

Compounds for genes affiliated with Peyronies Disease

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB
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Compounds related to Peyronies Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 107)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7PDE5A
2indomethacin45 60 29 1113.5PDE5A, HMOX1
3pge24510.4PDE4A, TGFB1
4ptio4510.3NOS2, SOD1, HMOX1
53-nitrotyrosine4510.3SOD1, NOS2, HMOX1
6onoo4510.3SERPINA1, NOS2, SOD1
7ebselen4510.3HMOX1, SOD1, NOS2
8deta nonoate4510.3NOS2, CCL2, HMOX1
9taurine bromamine4510.2NOS2, HMOX1
10bleomycin45 1111.2DCN, BMP6, IFNA2
11h2o24510.2PDE4A, PTN
12kt 582345 2911.2HMOX1, PDE5A, NOS2
13diphenyleneiodonium4510.1NOS2, TGFB1, SOD1, CCL2
14cycloheximide4510.1PDE4A
15vardenafil45 1111.1NOS2, PDE5A, PDE4A
164-hydroxynonenal45 2411.1TGFB1, SOD1, HMOX1, NOS2
178-bromo cgmp4510.0PDE4A, NOS2, PDE5A
18ng-nitro-l-arginine4510.0NOS2, SOD1, PDE4A
19pdtc4510.0CCL2, SOD1, HMOX1, NOS2, TGFB1
20sildenafil45 50 29 11 2414.0TGFB1, NOS2, PDE5A, PDE4A
21alpha lipoic acid4510.0CCL2, NOS2, SOD1, HMOX1, SERPINA1
22motapizone4510.0PDE5A, PDE4A
23allopurinol45 50 1111.9SOD1, IFNA2, HMOX1
24polyethylene glycol459.8TGFB1, BMP6, IFNA2, HMOX1
2515-deoxy-delta-12,14-prostaglandin j2459.8NOS2, HMOX1, BMP6, CCL2
26ascorbic acid45 2410.8IFNA2, SOD1, HMOX1, SERPINA1, NOS2
27superoxide45 2410.7TAGLN, CCL2, IFNA2, HMOX1, PDE4A
28cyclosporin a45 29 6011.6PDE4A, HMOX1, DCN, HLA-A, HLA-S
29tgf beta1459.6CCL2, BMP6, DCN, TAGLN, TGFB1
30creatinine459.6DCN, BMP6, SOD1, SERPINA1, TGFB1
31dexamethasone45 50 29 1112.6MSTN, BMP6, PDE4A, TGFB1, DCN
32ribonucleic acid459.6CCL2, MSTN, BMP6, DCN, TGFB1, IFNA2
33glycosaminoglycan459.6BMP6, TGFB1, DCN, PTN
34sb 20358045 6010.6TGFB1, HMOX1, BMP6, NOS2, CCL2
35acetylcholine45 50 29 11 2413.5PDE4A, TAGLN, HMOX1, BMP6, NOS2
36isoproterenol45 1110.5NOS2, BMP6, PDE5A, PDE4A, CCL2
37cisplatin45 50 60 1112.5SOD1, HMOX1, TGFB1, BMP6, IFNA2, CCL2
38guanylate459.4PDE5A, NOS2, HMOX1, PDE4A
39polysaccharide459.4TGFB1, DCN, BMP6, PTN, CCL2, SERPINA1
40sodium nitroprusside459.3PDE4A, TGFB1, PDE5A, BMP6, HMOX1, NOS2
41alanine459.2HLA-A, HMOX1, IFNA2, DCN, SOD1, BMP6
42prostacyclin459.2PDE4A, NOS2, HMOX1, BMP6, PDE5A, SOD1
43histamine45 29 2411.2IFNA2, HMOX1, TGFB1, CCL2, BMP6, PDE4A
44oxygen45 2410.2PDE4A, MSTN, NOS2, HMOX1, DCN, CCL2
45ly294002459.1BMP6, TGFB1, PTN, NOS2, PDE4A, CCL2
46norepinephrine45 11 2411.0HMOX1, PDE5A, PDE4A, BMP6
47arginine458.9CCL2, HLA-A, NOS2, HMOX1, TAGLN, DCN
48retinoic acid45 249.8BMP6, HMOX1, DCN, PTN, TGFB1, TAGLN
49nitric oxide45 11 2410.5DCN, CCL2, SOD1, PDE4A, PDE5A, HMOX1
50vegf458.4PTN, PDE5A, BMP6, DCN, POSTN, NOS2

GO Terms for genes affiliated with Peyronies Disease

Sources:
16Gene Ontology
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Cellular components related to Peyronies Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.3TGFB1, IFNA2, SOD1, BMP6, DCN, HMOX1

Biological processes related to Peyronies Disease according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of superoxide anion generationGO:03293010.3TGFB1, SOD1
2response to heatGO:00940810.1MSTN, SOD1, CCL2
3response to ethanolGO:0454719.9CCL2, SOD1, MSTN
4response to hypoxiaGO:0016669.9CCL2, NOS2, SERPINA1, TGFB1
5negative regulation of neuron apoptotic processGO:0435249.9HMOX1, SOD1, CCL2
6platelet degranulationGO:0025769.9TGFB1, SERPINA1, SOD1
7response to glucocorticoid stimulusGO:0513849.8MSTN, BMP6, CCL2
8blood coagulationGO:0075969.6TGFB1, SERPINA1, NOS2, PDE5A, SOD1, IFNA2
9inflammatory responseGO:0069549.6CCL2, IFNA2, BMP6, NOS2, TGFB1
10agingGO:0075689.6CCL2, DCN, TGFB1

Molecular functions related to Peyronies Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051029.7MSTN, NOS2, HLA-A, CCL2
2heparin bindingGO:0082019.5PTN, MSTN, POSTN, CCL2
3growth factor activityGO:0080839.1BMP6, MSTN, PTN, TGFB1

Products for genes affiliated with Peyronies Disease

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  • Proteins
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  • Antibodies

Sources for Peyronies Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet