MCID: PYR026
MIFTS: 32

Peyronies Disease malady

Summaries for Peyronies Disease

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MalaCards: Peyronies Disease is related to peyronie's disease and plantar fascial fibromatosis. An important gene associated with Peyronies Disease is IFNA2 (interferon, alpha 2), and among its related pathways are TGF-beta Signaling Pathway and NO-dependent CFTR activation (normal and CF). The compounds estrogen and indomethacin have been mentioned in the context of this disorder. Related mouse phenotypes are skeleton and reproductive system.

Aliases & Classifications for Peyronies Disease

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10DISEASES
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Aliases & Descriptions:

peyronies disease 10


Related Diseases for Peyronies Disease

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17GeneCards, 18GeneDecks
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Diseases related to Peyronies Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 152)
idRelated DiseaseScoreTop Affiliating Genes
1peyronie's disease30.6TGFB1, NOS2, PDE5A, SOD1, IFNA2
2plantar fascial fibromatosis10.0
3familial dupuytren contracture10.0
4lung cancer10.0TGFB1
5prostatitis10.0PDE5A
6rhinitis10.0PDE5A
7myeloma10.0IFNA2
8vitiligo10.0SOD1
9deficiency anemia10.0IFNA2
10neuropathy10.0MSTN
11bronchopulmonary dysplasia10.0SOD1
12coronary heart disease10.0PDE5A
13essential hypertension10.0SOD1
14myopathy10.0MSTN
15kidney cancer10.0IFNA2
16pneumoconiosis10.0SOD1
17hypercholesterolemia10.0NOS2
18gastritis10.0NOS2
19priapism10.0PDE5A
20biliary atresia10.0TGFB1
21skin disease10.0TGFB1
22migraine10.0PDE5A
23fibrosarcoma10.0TGFB1
24hepatopulmonary syndrome10.0HMOX1
25polyneuropathy10.0IFNA2
26alpha 1-antitrypsin deficiency10.0SERPINA1
27acute myocardial infarction10.0SERPINA1
28malaria10.0HLA-A
29ureteral obstruction10.0TGFB1
30diabetic retinopathy10.0NOS2, SOD1
31lichen planus10.0IFNA2
32nephritis10.0CCL2
33kawasaki disease10.0CCL2
34bronchiectasis10.0SERPINA1
35peritonitis10.0CCL2
36amyloidosis10.0DCN
37cryoglobulinemia10.0IFNA2
38ankylosing spondylitis10.0HLA-A
39dyspepsia10.0PDE5A
40celiac disease10.0HLA-A
41wilms tumor10.0PTN
42laryngeal benign neoplasm10.0HLA-A
43meningioma10.0PTN
44allergic rhinitis10.0PDE4A
45proliferative diabetic retinopathy10.0CCL2
46myocarditis10.0NOS2
47galactosemia10.0TGFB1, SERPINA1
48nephrotic syndrome10.0HLA-S, SERPINA1
49myelodysplastic syndromes10.0PDE4A
50viral hepatitis10.0SERPINA1, IFNA2

Graphical network of the top 20 diseases related to Peyronies Disease:



Diseases related to peyronies disease

Clinical Features for Peyronies Disease

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Drugs & Therapeutics for Peyronies Disease

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Peyronies Disease

Drug clinical trials:

Search ClinicalTrials for Peyronies Disease

Search NIH Clinical Center for Peyronies Disease

Search CenterWatch for Peyronies Disease

Genetic Tests for Peyronies Disease

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Anatomical Context for Peyronies Disease

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Animal Models for Peyronies Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Peyronies Disease:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.8DCN, POSTN, TAGLN, MSTN
2MP:00053899.4HMOX1, PTN, DCN, BMP6, TGFB1
3MP:00053829.4TGFB1, NOS2, POSTN, DCN, CCL2, MSTN
4MP:00053699.4POSTN, SOD1, TGFB1, MSTN, HMOX1, TAGLN
5MP:00053709.2MSTN, CCL2, SOD1, NOS2, PTN, TGFB1
6MP:00020069.2CCL2, DCN, POSTN, TGFB1, CUL9, TAGLN
7MP:00053858.7NOS2, HMOX1, TAGLN, POSTN, SOD1, PDE4A
8MP:00053868.5HMOX1, DCN, SOD1, TAGLN, CCL2, NOS2
9MP:00053848.5DCN, CCL2, PTN, SOD1, HMOX1, CUL9
10MP:00053878.3PDE4A, CCL2, TAGLN, TGFB1, SOD1, HMOX1
11MP:00053788.2NOS2, CUL9, HMOX1, TAGLN, POSTN, DCN
12MP:00053768.1PTN, DCN, POSTN, HMOX1, CUL9, TGFB1

Publications for Peyronies Disease

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Genetic Variations for Peyronies Disease

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Expression for genes affiliated with Peyronies Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Peyronies Disease

Search GEO for disease gene expression data for Peyronies Disease.

Pathways for genes affiliated with Peyronies Disease

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55SinoBiological, 53Reactome, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN
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Pathways related to Peyronies Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1DCN, MSTN
2
NO-dependent CFTR activation (normal and CF)
10.1NOS2, PDE5A
3
Hide members
10.0TGFB1, SERPINA1, SOD1
49.8HMOX1, DCN, CCL2
59.7BMP6, DCN, TGFB1
6
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9.2TGFB1, PTN, BMP6, IFNA2, CCL2

Compounds for genes affiliated with Peyronies Disease

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Peyronies Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 107)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7PDE5A
2indomethacin44 59 28 1113.5HMOX1, PDE5A
3pge24410.4TGFB1, PDE4A
4ptio4410.3SOD1, HMOX1, NOS2
53-nitrotyrosine4410.3SOD1, HMOX1, NOS2
6onoo4410.3SERPINA1, NOS2, SOD1
7ebselen4410.3NOS2, HMOX1, SOD1
8deta nonoate4410.3NOS2, HMOX1, CCL2
9taurine bromamine4410.2HMOX1, NOS2
10kt 582344 2811.2PDE5A, HMOX1, NOS2
11bleomycin44 1111.2DCN, BMP6, IFNA2
12h2o24410.2PTN, PDE4A
13diphenyleneiodonium4410.1CCL2, SOD1, NOS2, TGFB1
14cycloheximide4410.1PDE4A
15vardenafil44 1111.1PDE4A, PDE5A, NOS2
164-hydroxynonenal44 2411.1SOD1, HMOX1, NOS2, TGFB1
178-bromo cgmp4410.0PDE4A, PDE5A, NOS2
18motapizone4410.0PDE4A, PDE5A
19ng-nitro-l-arginine4410.0SOD1, PDE4A, NOS2
20pdtc4410.0CCL2, SOD1, HMOX1, NOS2, TGFB1
21sildenafil44 49 28 11 2414.0PDE4A, PDE5A, NOS2, TGFB1
22alpha lipoic acid4410.0CCL2, SOD1, HMOX1, NOS2, SERPINA1
23allopurinol44 49 1111.9HMOX1, SOD1, IFNA2
24polyethylene glycol449.8TGFB1, HMOX1, BMP6, IFNA2
2515-deoxy-delta-12,14-prostaglandin j2449.8CCL2, BMP6, HMOX1, NOS2
26ascorbic acid44 2410.8IFNA2, SOD1, HMOX1, NOS2, SERPINA1
27superoxide44 2410.7CCL2, IFNA2, PDE4A, TAGLN, HMOX1
28cyclosporin a44 28 5911.6PDE4A, HLA-S, HLA-A, DCN, HMOX1
29tgf beta1449.6CCL2, BMP6, DCN, TAGLN, TGFB1
30creatinine449.6SOD1, BMP6, DCN, SERPINA1, TGFB1
31dexamethasone44 49 28 1112.6TGFB1, MSTN, DCN, BMP6, PDE4A
32ribonucleic acid449.6CCL2, IFNA2, BMP6, DCN, MSTN, TGFB1
33glycosaminoglycan449.6TGFB1, PTN, DCN, BMP6
34sb 20358044 5910.6TGFB1, NOS2, HMOX1, BMP6, CCL2
35acetylcholine44 49 28 11 2413.5NOS2, HMOX1, TAGLN, BMP6, PDE4A
36isoproterenol44 1110.5CCL2, PDE4A, PDE5A, BMP6, NOS2
37cisplatin44 49 59 1112.5CCL2, IFNA2, SOD1, BMP6, HMOX1, TGFB1
38guanylate449.4NOS2, HMOX1, PDE5A, PDE4A
39polysaccharide449.4CCL2, BMP6, DCN, PTN, SERPINA1, TGFB1
40sodium nitroprusside449.3SOD1, PDE4A, PDE5A, BMP6, HMOX1, NOS2
41alanine449.2IFNA2, SOD1, BMP6, HLA-A, DCN, HMOX1
42prostacyclin449.2CCL2, SOD1, PDE4A, PDE5A, BMP6, HMOX1
43histamine44 28 2411.2CCL2, IFNA2, PDE4A, PDE5A, BMP6, HMOX1
44oxygen44 2410.2CCL2, PDE4A, PDE5A, DCN, HMOX1, NOS2
45ly294002449.1CCL2, PDE4A, BMP6, HMOX1, NOS2, PTN
46norepinephrine44 11 2411.0PDE4A, PDE5A, BMP6, HMOX1
47arginine448.9CCL2, SOD1, PDE4A, PDE5A, HLA-A, DCN
48retinoic acid44 249.8IFNA2, PDE4A, BMP6, DCN, TAGLN, HMOX1
49nitric oxide44 11 2410.5CCL2, SOD1, PDE4A, PDE5A, BMP6, DCN
50vegf448.4TGFB1, CCL2, IFNA2, PDE4A, PDE5A, BMP6

GO Terms for genes affiliated with Peyronies Disease

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16Gene Ontology
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Cellular components related to Peyronies Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.3TGFB1, IFNA2, SOD1, BMP6, DCN, HMOX1

Biological processes related to Peyronies Disease according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of superoxide anion generationGO:03293010.3SOD1, TGFB1
2response to heatGO:00940810.1SOD1, MSTN, CCL2
3response to ethanolGO:0454719.9MSTN, CCL2, SOD1
4response to hypoxiaGO:0016669.9TGFB1, SERPINA1, CCL2, NOS2
5negative regulation of neuron apoptotic processGO:0435249.9SOD1, CCL2, HMOX1
6platelet degranulationGO:0025769.9TGFB1, SOD1, SERPINA1
7response to glucocorticoid stimulusGO:0513849.8BMP6, MSTN, CCL2
8blood coagulationGO:0075969.6NOS2, SERPINA1, TGFB1, PDE5A, SOD1, IFNA2
9inflammatory responseGO:0069549.6CCL2, IFNA2, BMP6, NOS2, TGFB1
10agingGO:0075689.6TGFB1, DCN, CCL2

Molecular functions related to Peyronies Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051029.7CCL2, HLA-A, NOS2, MSTN
2heparin bindingGO:0082019.5CCL2, POSTN, MSTN, PTN
3growth factor activityGO:0080839.1BMP6, MSTN, PTN, TGFB1

Products for genes affiliated with Peyronies Disease

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Sources for Peyronies Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet