MCID: PFF001
MIFTS: 73

Pfeiffer Syndrome malady

Categories: Genetic diseases, Rare diseases, Infectious diseases, Eye diseases, Bone diseases, Fetal diseases, Skin diseases, Endocrine diseases

Aliases & Classifications for Pfeiffer Syndrome

About this section
Sources:
2CDC, 11Disease Ontology, 12diseasecard, 13DISEASES, 25Genetics Home Reference, 26GTR, 29ICD10, 30ICD10 via Orphanet, 31ICD9CM, 35MalaCards, 36MedGen, 37MedlinePlus, 38MeSH, 39MESH via Orphanet, 44NCIt, 47NIH Rare Diseases, 49Novoseek, 51OMIM, 53Orphanet, 61SNOMED-CT, 63The Human Phenotype Ontology, 67UMLS, 68UMLS via Orphanet, 69UniProtKB/Swiss-Prot, 70Wikipedia
See all MalaCards sources

Aliases & Descriptions for Pfeiffer Syndrome:

Name: Pfeiffer Syndrome 51 35 11 70 47 25 53 69 12 49 13 67
Infectious Mononucleosis 35 11 49 37 2 38 13 67
Acs5 47 25 53 69
Craniofacial-Skeletal-Dermatologic Dysplasia 51 25 12
Acrocephalosyndactyly Type 5 47 53 69
Pfeiffer Type Acrocephalosyndactyly 47 67
Pfeiffer's Disease 11 26
Acs V 25 69
Gammaherpesviral Mononucleosis 11
 
Acrocephalosyndactylia Type V 11
Acrocephalosyndactyly, Type V 25
Acrocephalosyndactyly, Type 5 47
Filatov's Disease 11
Monocytic Angina 11
Glandular Fever 11
Noack Syndrome 25
Mononucleosis 11
Ps 69

Characteristics:

Orphanet epidemiological data:

53
pfeiffer syndrome:
Inheritance: Autosomal dominant; Prevalence: 1-9/100000 (Europe); Age of onset: Antenatal,Neonatal; Age of death: any age

HPO:

63
pfeiffer syndrome:
Inheritance: autosomal dominant inheritance

Classifications:



External Ids:

OMIM51 101600
Disease Ontology11 DOID:14705, DOID:8568
ICD1029 B27, B27.0, B27.9
ICD9CM31 075
Orphanet53 ORPHA710
ICD10 via Orphanet30 Q87.0
MESH via Orphanet39 C538582
UMLS via Orphanet68 C2931888

Summaries for Pfeiffer Syndrome

About this section
OMIM:51 Pfeiffer syndrome is an autosomal dominant craniosynostosis syndrome with characteristic anomalies of the hands and... (101600) more...

MalaCards based summary: Pfeiffer Syndrome, also known as infectious mononucleosis, is related to pfeiffer syndrome type 1 and pfeiffer syndrome type 2, and has symptoms including ptosis, abnormality of thumb phalanx and hypoplasia of the zygomatic bone. An important gene associated with Pfeiffer Syndrome is FGFR2 (Fibroblast Growth Factor Receptor 2), and among its related pathways are Alzheimers Disease Pathway and Central carbon metabolism in cancer. Affiliated tissues include skull, bone and t cells, and related mouse phenotypes are hearing/vestibular/ear and embryo.

Disease Ontology:11 An acrocephalosyndactylia that has material basis in mutations in the FGFR1 and FGFR2 gene which results in premature fusion located in skull.

Genetics Home Reference:25 Pfeiffer syndrome is a genetic disorder characterized by the premature fusion of certain skull bones (craniosynostosis). This early fusion prevents the skull from growing normally and affects the shape of the head and face. Pfeiffer syndrome also affects bones in the hands and feet.

NIH Rare Diseases:47 Pfeiffer syndrome is a disorder that affects the development of the bones in the skull, hands and feet. Signs and symptoms can include craniosynostosis, which prevents normal skull growth and affects the shape of the head and face; distinctive facial features including bulging and wide-set eyes, a high forehead, an underdeveloped upper jaw, and a beaked nose; hearing loss; and dental problems. Other features may include broad and deviated thumbs and great toes; brachydactyly; and syndactyly. It is caused by mutations in the FGFR1 or FGFR2 genes and is inherited in an autosomal dominant manner. Pfeiffer syndrome is divided into 3 subtypes (type 1, type 2 and type 3) based on the presence and severity of specific features. Management typically includes various surgical interventions. Last updated: 7/12/2016

MedlinePlus:37 Infectious mononucleosis, or "mono", is an infection usually caused by the epstein-barr virus. the virus spreads through saliva, which is why it's sometimes called "kissing disease." mono occurs most often in teens and young adults. however, you can get it at any age. symptoms of mono include fever sore throat swollen lymph glands sometimes you may also have a swollen spleen. serious problems are rare. a blood test can show if you have mono. most people get better in two to four weeks. however, you may feel tired for a few months afterward. treatment focuses on helping symptoms and includes medicines for pain and fever, warm salt water gargles and plenty of rest and fluids.

CDC:2 Epstein-Barr virus, or EBV, is one of the most common human viruses in the world. It spreads primarily through saliva. EBV can cause infectious mononucleosis, also called mono, and other illnesses. Most people will get infected with EBV in their lifetime and will not have any symptoms. Mono caused by EBV is most common among teens and adults…

UniProtKB/Swiss-Prot:69 Pfeiffer syndrome: A syndrome characterized by the association of craniosynostosis, broad and deviated thumbs and big toes, and partial syndactyly of the fingers and toes. Three subtypes are known: mild autosomal dominant form (type 1); cloverleaf skull, elbow ankylosis, early death, sporadic (type 2); craniosynostosis, early demise, sporadic (type 3).

Wikipedia:70 Pfeiffer syndrome is a very rare genetic disorder characterized by the premature fusion of certain bones... more...

Related Diseases for Pfeiffer Syndrome

About this section

Diseases in the Pfeiffer Syndrome family:

Pfeiffer Syndrome Type 1 Pfeiffer Syndrome Type 1, 2 and 3
Pfeiffer Syndrome Type 3 Pfeiffer Syndrome Type 2

Diseases related to Pfeiffer Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 180)
idRelated DiseaseScoreTop Affiliating Genes
1pfeiffer syndrome type 111.9
2pfeiffer syndrome type 211.9
3pfeiffer syndrome type 311.8
4pfeiffer syndrome type 1, 2 and 311.8
5winkelman bethge pfeiffer syndrome11.7
6lymphoproliferative syndrome, x-linked, 111.6
7cytomegalovirus infection11.2
8scott syndrome11.0
9proteus syndrome, somatic11.0
10post-transplant lymphoproliferative disease10.9
11perlman syndrome10.8
12polydactyly, preaxial type ii10.8
13werner syndrome10.8
14pituitary hormone deficiency, combined, 310.7
15ulna and fibula, hypoplasia of10.7
16pfn1-related amyotrophic lateral sclerosis10.6FGFR1, FGFR2
17flnb-related disorders10.5FGFR1, FGFR2, FGFR3
18trigonocephaly 110.5FGFR1, FGFR2, FGFR3
19hypogonadotropic hypogonadism 2 with or without anosmia10.5FGFR1, FGFR2, FGFR3
20thanatophoric dysplasia, type i10.5FGFR1, FGFR2, FGFR3
21beare-stevenson cutis gyrata syndrome10.5FGFR1, FGFR2, FGFR3
22staphylococcal scarlet fever10.5FGFR3, TWIST1
23hypochondroplasia10.4FGFR1, FGFR2, FGFR3
24nail disorder, nonsyndromic congenital, 110.4BGLAP, FGFR1, SP7
25peripheral osteosarcoma10.4BGLAP, RUNX2, SP7
26deafness, autosomal recessive 9110.4COL1A1, COL3A1
27mite infestation10.4FGFR2, FGFR3
28syphilitic myelopathy10.3COL1A1, FGFR1, FGFR3, RUNX2
29bone deterioration disease10.3BGLAP, RUNX2, SP7
30crouzon syndrome with acanthosis nigricans10.3FGF8, FGFR2, FGFR3
31y-linked disease10.3ALPL, FGFR2, FGFR3
32vulvovaginitis10.3BGLAP, FGFR2, RUNX2, SP7
33lymphoma10.3
34plasmalogens synthesis deficiency isolated10.2FGFR1, FGFR2, FGFR3, TWIST1
35physical disorder10.2BGLAP, COL1A1, RUNX2, SP7
36bladder cancer, somatic10.2FGFR1, FGFR2, FGFR3, TWIST1
37hodgkin's lymphoma, lymphocytic-histiocytic predominance10.2CD40LG, COL1A1, COL3A1
38adult astrocytic tumour10.2FGFR1, FGFR3, TWIST1
39juvenile type testicular granulosa cell tumor10.2CD40LG, SH2D1A
40hepatitis10.2
41diabetic angiopathy10.1CD40LG, SH2D1A
42apert syndrome10.1FGFR2, FGFR3
43tonsillitis10.1
44vulvovaginal candidiasis10.1ALPL, BGLAP, COL1A1, FGFR3, SP7
45splenic infarction10.1
46craniosynostosis10.0
47leukemia10.0
48hodgkin lymphoma9.9
49pneumonia9.9
50chronic fatigue syndrome9.9

Graphical network of the top 20 diseases related to Pfeiffer Syndrome:



Diseases related to pfeiffer syndrome

Symptoms for Pfeiffer Syndrome

About this section

Symptoms by clinical synopsis from OMIM:

101600

Clinical features from OMIM:

101600

Human phenotypes related to Pfeiffer Syndrome:

 63 53 (show all 49)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ptosis63 53 hallmark (90%) Very frequent (99-80%) HP:0000508
2 abnormality of thumb phalanx63 hallmark (90%) HP:0009602
3 hypoplasia of the zygomatic bone63 hallmark (90%) HP:0010669
4 hypertelorism63 53 typical (50%) Frequent (79-30%) HP:0000316
5 high forehead63 53 typical (50%) Frequent (79-30%) HP:0000348
6 wide nasal bridge63 53 typical (50%) Frequent (79-30%) HP:0000431
7 brachydactyly syndrome63 53 typical (50%) Frequent (79-30%) HP:0001156
8 clinodactyly of the 5th finger63 53 typical (50%) Frequent (79-30%) HP:0004209
9 finger syndactyly63 53 typical (50%) Frequent (79-30%) HP:0006101
10 symphalangism affecting the phalanges of the hand63 53 typical (50%) Frequent (79-30%) HP:0009773
11 abnormality of the palate63 occasional (7.5%) HP:0000174
12 open mouth63 53 occasional (7.5%) Occasional (29-5%) HP:0000194
13 malar flattening63 occasional (7.5%) HP:0000272
14 mandibular prognathia63 53 occasional (7.5%) Occasional (29-5%) HP:0000303
15 short philtrum63 53 occasional (7.5%) Occasional (29-5%) HP:0000322
16 facial asymmetry63 53 occasional (7.5%) Occasional (29-5%) HP:0000324
17 short neck63 53 occasional (7.5%) Occasional (29-5%) HP:0000470
18 abnormality of the hip bone63 occasional (7.5%) HP:0003272
19 hyperlordosis63 53 occasional (7.5%) Occasional (29-5%) HP:0003307
20 short stature63 53 occasional (7.5%) Occasional (29-5%) HP:0004322
21 synostosis of carpal bones63 53 occasional (7.5%) Occasional (29-5%) HP:0005048
22 high palate63 53 Occasional (29-5%) HP:0000218
23 hydrocephalus63 HP:0000238
24 brachyturricephaly63 HP:0000244
25 hypoplasia of the maxilla63 HP:0000327
26 choanal stenosis63 HP:0000452
27 choanal atresia63 HP:0000453
28 strabismus63 HP:0000486
29 downslanted palpebral fissures63 HP:0000494
30 shallow orbits63 HP:0000586
31 dental crowding63 HP:0000678
32 intellectual disability63 HP:0001249
33 arnold-chiari malformation63 HP:0002308
34 cloverleaf skull63 HP:0002676
35 bronchomalacia63 HP:0002780
36 humeroradial synostosis63 HP:0003041
37 elbow ankylosis63 HP:0003070
38 short nose63 HP:0003196
39 short middle phalanx of toe63 HP:0003795
40 coronal craniosynostosis63 HP:0004440
41 depressed nasal bridge63 HP:0005280
42 cartilaginous trachea63 HP:0005347
43 shortening of all middle phalanges of the fingers63 HP:0006110
44 broad hallux63 HP:0010055
45 broad thumb63 53 Very frequent (99-80%) HP:0011304
46 turricephaly53 Frequent (79-30%)
47 hip dysplasia53 Occasional (29-5%)
48 cheekbone underdevelopment53 Very frequent (99-80%)
49 flat face53 Occasional (29-5%)

UMLS symptoms related to Pfeiffer Syndrome:


pruritus

Drugs & Therapeutics for Pfeiffer Syndrome

About this section

Drugs for Pfeiffer Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 69)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Immunoglobulins, IntravenousPhase 3324
2Rho(D) Immune GlobulinPhase 3317
3ImmunoglobulinsPhase 3, Phase 16045
4AntibodiesPhase 3, Phase 16045
5Immunoglobulin GPhase 3265
6gamma-GlobulinsPhase 3317
7
Paclitaxelapproved, vet_approvedPhase 2275833069-62-436314
Synonyms:
(2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester
12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
157069-30-2
33069-62-4
5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxete,benzenepropanoic acid deriv.
7-Epi-Paclitaxel
7-Epi-Taxol
7-Epipaclitaxel
7-Epitaxol
7-epi-Paclitaxel
7-epi-Taxol
AB00513812
ABI 007
ABI-007
ABI007
AC-675
AC1L1IOG
AC1L1VJI
AC1L9AVF
ACon1_002231
ANX-513
Abraxane
Abraxane (TN)
Abraxane I.V. Suspension
Abraxis BioScience brand of albumin-bound paclitaxel
Ambotz33069-62-4
Anzatax
Asotax
BIDD:PXR0046
BMS 181339-01
BMS-181339
BMS-181339-01
BPBio1_000320
BRD-A23723433-001-01-2
BRD-A28746609-001-04-0
BRD-K62008436-001-03-1
BSPBio_000290
BSPBio_001152
BSPBio_002614
Bio-0076
Bio1_000362
Bio1_000851
Bio1_001340
Bio2_000416
Bio2_000896
Bristaxol
C07394
C466458
C47H51NO14
CCRIS 8143
CHEBI:103439
CHEBI:45863
CHEMBL100910
CHEMBL418410
CHEMBL48
CID36314
CID441276
CID4666
CID6713921
CID6915727
CPD-8718
Capxol
D00491
DB01229
DHP-107
DHP-208
DRG-0190
DTS-301
DivK1c_000441
EU-0101201
Ebetaxel
EmPAC
Epitaxol
Genaxol
Genetaxyl
Genexol
Genexol-PM
HMS1362J13
HMS1568O12
HMS1792J13
HMS1922K08
HMS1990J13
HMS2090D07
HMS2093K15
HMS501G03
HSDB 6839
I06-0014
IDI1_000441
IDI1_002171
Intaxel
KBio1_000441
KBio2_000492
KBio2_002016
KBio2_002509
KBio2_003060
KBio2_004584
KBio2_005077
KBio2_005628
KBio2_007152
KBio2_007645
KBio3_000903
KBio3_000904
KBio3_001834
KBio3_002987
KBioGR_000492
KBioGR_001893
 
KBioGR_002509
KBioSS_000492
KBioSS_002016
KBioSS_002517
LMPR0104390001
LS-31070
LipoPac
Lopac0_001201
MBT 0206
MEGxp0_001940
MLS000863266
MLS001077297
MLS002154218
MLS002172439
MLS002695976
MPI-5018
Micellar Paclitaxel
Mitotax
MolPort-001-742-627
MolPort-003-665-783
MolPort-003-932-365
NCGC00024995-02
NCGC00024995-03
NCGC00024995-04
NCGC00024995-05
NCGC00024995-06
NCGC00024995-07
NCGC00164367-01
NCGC00164367-02
NCGC00164367-03
NCI60_000601
NINDS_000441
NK 105
NP-010981
NSC 125973
NSC-125973
NSC125973
NSC358882
Nanotaxel
Neuro_000060
Nova-12005
OAS-PAC-100
OncoGel
Onxal
Onxol
Onxol, Taxol, Nov-Onxol, Paclitaxel
P1632
Paclical
Pacligel
Paclitaxel
Paclitaxel (JAN/USP)
Paclitaxel (JAN/USP/INN)
Paclitaxel (Taxol)
Paclitaxel [USAN:INN:BAN]
Paxceed
Paxene
Paxoral
Plaxicel
Praxel
Prestwick0_000155
Prestwick1_000155
Prestwick2_000155
Prestwick3_000155
Probes2_000350
QW 8184
S-8184 Paclitaxel Injectable Emulsion
S1150_Selleck
SDCCGMLS-0066823.P001
SDP-013
SMP1_000228
SMR000394086
SMR000857385
SPBio_000943
SPBio_002229
SPECTRUM1503908
ST50306996
Spectrum2_000872
Spectrum3_001057
Spectrum4_001197
Spectrum5_001491
Spectrum_001536
T 7402
T1912_SIGMA
T7191_SIGMA
T7402_SIGMA
TA1
TAXOL (TN)
TAXOL, 10-EPI,
TXL
TaxAlbin
Taxol
Taxol A
Taxol Konzentrat
Taxol.RTM. (Registered Trademark)
UNII-P88XT4IS4D
UPCMLD-DP108:001
UPCMLD-DP108:002
Vascular Wrap
Xorane
Yewtaxan
abi-007
albumin-bound paclitaxel
cMAP_000068
nab-paclitaxel
nchembio.188-comp1
nchembio.2007.34-comp9
nchembio.215-comp9
nchembio853-comp6
paclitaxel
weekly paclitaxel
8
LenograstimapprovedPhase 21202135968-09-1
Synonyms:
G-CSF (CHO cell derived)
Glycosylated recombinant G-CSF
Glycosylated recombinant granulocyte colony stimulating factor
 
Granulocyte colony stimulating factor 3 (CHO cell derived)
Granulocyte colony-stimulating factor lenograstim
Lenograstim (genetical recombination)
Lenograstim rDNA
9
CarboplatinapprovedPhase 2198041575-94-410339178, 498142, 38904
Synonyms:
(SP-4-2)-diammine[cyclobutane-1,1-dicarboxylato(2-)-kappa(2)O,O']platinum
/h1-3H2,(H,7,8)(H,9,10)
/q
1,1-Cyclobutanedicarboxylate diammine platinum (II)
1,1-Cyclobutanedicarboxylate diammine platinum(II)
2*-1
2*1H2
41575-94-4
70903-55-8
AC-1457
AC1L8I6U
Ambap41575-94-4
BSPBio_003145
C 2538
C2043
C2538_SIGMA
C6H10N2O4Pt
CBDCA
CCRIS 3404
CHEBI:31355
CHEMBL1351
CHEMBL288376
CID10339178
CID2567
CID38904
CID426756
CID498142
CID5352133
CID6398587
CID6603770
Carbopaltin
Carboplatin
Carboplatin (JAN/USP/INN)
Carboplatin (USAN)
Carboplatin [USAN:INN:BAN:JAN]
Carboplatine
Carboplatine [French]
Carboplatino
Carboplatino [Spanish]
Carboplatinum
Carboplatinum [Latin]
Cbdca
Cyclobutane-1,1-dicarboxylate
D01363
DB00958
Diammine(1,1-cyclobutanedicarboxylato)platinum (II)
Diammine(cyclobutane-1,1-dicarboxylato(2-)-O,O')platinum
Diammine-1,1-cyclobutane dicarboxylate platinum II
DivK1c_000892
EINECS 255-446-0
EU-0100230
Ercar
HMS1921J16
HMS2090M05
HMS2092B22
HMS502M14
HSDB 6957
I14-2390
IDI1_000892
IUPAC: Azane
InChI=1/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6
 
JM 8
JM-8
KBio1_000892
KBio2_002009
KBio2_004577
KBio2_007145
KBio3_002645
KBioGR_000713
KBioSS_002009
LS-117689
Lopac-C-2538
Lopac0_000230
MolPort-003-665-501
MolPort-003-845-609
NCGC00015223-01
NCGC00093695-01
NCGC00094961-01
NCGC00094961-02
NCGC00094961-03
NCGC00162099-01
NCGC00162099-02
NCGC00167800-01
NCGC00178242-01
NINDS_000892
NSC 201345
NSC 241240
NSC-241240
NSC201345
NSC241240
Paraplatin
Paraplatin (TN)
Paraplatin, Carboplatin
Paraplatin-AQ
Platinum(+2) Cation
Platinum(II), (1, 1-cyclobutanedicar
Platinum, diammine(1,1-cyclobutanedicarboxylato(2-)-O,O')-, (SP-4-2)
Platinum, {diammine[1,1-cyclobut
S1215_Selleck
SPBio_000716
SPECTRUM1502106
Spectrum2_000898
Spectrum3_001503
Spectrum4_000337
Spectrum5_001094
Spectrum_001529
UNII-BG3F62OND5
azanide
carboplatin
cis -Diammine[1,1-cyclobutane-dicarboxylato] platinum
cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II)
cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(ii)
cis-Diamine(1,1-cyclobutanedicarboxylato)platinum(II)
cis-Diamine[1,1-cyclobutanedicarboxylato]platinum(II)
cis-Diammine(1,1-cyclobutanedicarboxylato) platinum
cis-Diammine(1,1-cyclobutanedicarboxylato)platinum
cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)
cis-Diammine(cyclobutanedicarboxylato)platinum II
cyclobutane-1,1-dicarboxylic acid
diammine[cyclobutane-1,1-dicarboxylato(2-)-k2O1,O1]platinum
nchembio.573-comp10
nchembio773-comp2
nchembio873-comp3
platinum(2+)
10
Dexamethasoneapproved, investigational, vet_approvedPhase 2208450-02-25743
Synonyms:
(3H)-Dexamethasone
.delta.(sup 1)-9-.alpha.-Fluoro-16-.alpha.-methylcortisol
.gamma.corten
1-Dehydro-16.alpha.-methyl-9.alpha.-fluorohydrocortisone
1-Dehydro-16alpha -methyl-9alpha -fluorohydrocortisone
1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone
1-Dehydro-16α-methyl-9α-fluorohydrocortisone
137098-19-2
16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol
16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone
16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone
16-alpha-Methyl-9-alpha-fluoroprednisolone
16.alpha.-Methyl-9.alpha.-fluoro-1-dehydrocortisol
16.alpha.-Methyl-9.alpha.-fluoroprednisolone
16alpha -Methyl-9alpha -fluoro-1-dehydrocortisol
16alpha -Methyl-9alpha -fluoroprednisolone
16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol
16alpha-Methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone
16alpha-Methyl-9alpha-fluoroprednisolone
16α-Methyl-9α-fluoro-1-dehydrocortisol
23495-06-9
31375_FLUKA
46165_FLUKA
46165_RIEDEL
50-02-2
8054-59-9
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11alpha -methylpregna-1,4-diene-3,20-dione
9-Fluoro-16-methylprednisolone
9-alpha-Fluoro-16-alpha-methylprednisolone
9.alpha.-Fluoro-16.alpha.-methylprednisolone
906422-84-2
9A-FLUORO-16BETA-METHYLPREDNISOLONE
9alpha -Fluoro-16alpha -methylprednisolone
9alpha-Fluoro-16alpha-methylprednisolone
9alpha-fluoro-16alpha-methyl-Prednisolone
9α-Fluoro-16α-methylprednisolone
AC-11056
AC1L1L1H
AC1Q29DM
AI3-50934
Adexone
Aeroseb-D
Aeroseb-Dex
Aeroseb-dex
Ak Dex Oph Otic Soln 0.1%
Alcon Brand of Dexamethasone
Anaflogistico
Aphtasolon
Aphthasolone
Apo-dexamethasone
Auxiron
Azimycin (veterinary)
Azium
Azium (Veterinary)
Azium (veterinary)
BIDD:ER0494
BIDD:PXR0060
BRD-K38775274-001-02-3
BRD-K38775274-001-06-4
BSPBio_000995
Bisu DS
Bisu Ds
C15643
C22H29FO5
CCRIS 7067
CHEBI:41879
CHEMBL384467
CID5743
CPD-10549
CPD001227192
Calonat
Corson
Corsone
Cortisumman
D00292
D003907
D1756_SIGMA
D4902_SIGMA
D6645_SIGMA
D8893_SIGMA
D9184_SIGMA
DB01234
DEX
DEXA
DEXONE 0.5
DEXONE 0.75
DEXONE 1.5
DEXONE 4
DXM
DXMS
Decacort
Decacortin
Decaderm
Decadron
Decadron (TN)
Decadron Tablets, Elixir
Decadron, Dexamethasone
Decadron-LA
Decadron-La
Decagel
Decaject
Decaject L.A.
Decaject-L.A.
Decalix
Decameth
Decasone
Decaspray
Dectancyl
Dekacort
Delta1-9alpha-Fluoro-16alpha-methylcortisol
Deltafluorene
Dergramin
Deronil
Desadrene
Desametasone
Desametasone [DCIT]
Desametasone [Dcit]
Desamethasone
Desameton
Deseronil
Dex-Ide
Dex-ide
Dexa
Dexa Mamallet
Dexa mamallet
Dexa-Cortidelt
Dexa-Cortisyl
Dexa-Mamallet
Dexa-Scheroson
Dexa-Sine
Dexa-cortidelt
Dexa-cortisyl
Dexa-scheroson
Dexa-sine
Dexacen-4
Dexacidin
Dexacort
Dexacortal
Dexacortin
Dexadeltone
Dexafarma
Dexair
Dexalona
Dexaltin
Dexametasona
Dexametasona [INN-Spanish]
Dexametasone
 
Dexameth
Dexamethansone
Dexamethasone
Dexamethasone (JP15/USP/INN)
Dexamethasone Acetate
Dexamethasone Alcohol
Dexamethasone Base
Dexamethasone Intensol
Dexamethasone Sodium Phosphate
Dexamethasone [INN:BAN:JAN]
Dexamethasone alcohol
Dexamethasone base
Dexamethasone intensol
Dexamethasone-omega
Dexamethasonum
Dexamethasonum [INN-Latin]
Dexamethazone
Dexamonozon
Dexapolcort
Dexapos
Dexaprol
Dexason
Dexasone
Dexasone 0.5mg
Dexasone 0.75mg
Dexasone 4mg
Dexasporin
Dexinolon
Dexinoral
Dexone
Dexone 0.5
Dexone 0.75
Dexone 1.5
Dexone 4
Dexonium
Dexpak
Dextelan
Dezone
Dinormon
Dxms
ECR Brand of Dexamethasone
EINECS 200-003-9
FT-0080377
Fluormethylprednisolone
Fluormone
Fluorocort
Fortecortin
Foy Brand of Dexamethasone
Gammacorten
HL-dex
HMS1792A17
HMS1990A17
HMS2089N13
HSDB 3053
Hexadecadrol
Hexadrol
Hexadrol Elixir
Hexadrol Tablets
Hexadrol elixir
Hl-Dex
Hl-dex
I06-1196
ICN Brand of Dexamethasone
IontoDex
Isopto-Dex
Isopto-dex
LS-7300
Lokalison F
Lokalison f
Loverine
Luxazone
MK 125
MLS001055412
MLS001332507
MLS001332508
Maxidex
Maxidex Ont 0.1%
Maxidex Sus 0.1%
Maxitrol
Mediamethasone
Merck Brand of Dexamethasone
Merz Brand 1 of Dexamethasone
Merz Brand 2 of Dexamethasone
Methylfluorprednisolone
Mexidex
Millicorten
MolMap_000018
MolPort-003-846-433
Mymethasone
NCGC00091019-01
NCGC00091019-02
NCGC00091019-03
NCGC00091019-04
NCGC00091019-05
NCI60_003067
NSC 34521
NSC34521
Naquasone (veterinary)
Neomycin and polymyxin b sulfates and dexamethasone
Neomycin and polymyxin b sulphates and dexamethasone
OTO-104
Ocu-Trol
Ocu-trol
Oradexon
PHL-dexamethasone
PMS-dexamethasone
Pet Derm III
Pet Derm Iii
Pet derm III
Pet-Derm Iii
Pms Dexamethasone Elixir 0.5mg/5ml
Policort
Posurdex
Prednisolon F
Prednisolon f
Prednisolone F
Prednisolone f
Prodex
S1322_Selleck
SAM002548948
SGCUT00126
SK-Dexamethasone
SK-dexamethasone
SMP1_000092
SMR000857119
SMR001227192
ST50307091
Sandoz dexamethasone
Sk-Dexamethasone
Spectrum5_002019
Spoloven
Sunia Sol D
Sunia sol D
Superprednol
TL8003317
Tobradex
Tobramycin and dexamethasone
Tresaderm (veterinary)
Turbinaire
UNII-7S5I7G3JQL
Visumetazone
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ G1
ZINC03875332
alpha -Fluoro-16-alpha -methylcortisol
delta(Sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta1-9alpha-Fluoro-16alpha-methylcortisol
dexamethasone
nchembio809-comp2
to_000038
11
ponatinibapprovedPhase 231943319-70-824826799
Synonyms:
AP 24534
AP24534
 
Iclusig
Ponatinibum
ponatinib
12
Docetaxelapproved, investigational, Approved May 1996Phase 21918114977-28-5148124, 9877265
Synonyms:
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl (aR,bS)-b-[[(1,1-dimethylethoxy)carbonyl]amino]-a-hydroxybenzenepropanoate
(2alpha,5beta,7beta,10beta,13alpha)-4-(acetyloxy)-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
01885_FLUKA
114977-28-5
4-(Acetyloxy)-13alpha-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7beta,10beta-trihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate
4-(acetyloxy)-13alpha-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7beta,10beta-trihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate
AC-383
AC1L3WHJ
ANX-514
BIND-014
C11231
CHEBI:4672
CHEMBL92
CID148124
D07866
DB01248
Docetaxel
Docetaxel (INN)
Docetaxel anhydrous
Docetaxel, Trihydrate
EmDOC
 
HMS2089K08
InChI=1/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,5
MolPort-003-847-005
N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxel
N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol
N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxel
N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol
N-debenzoyl-N-Boc-10-deacetyl taxol
NSC-628503
PSMA-targeted docetaxel nanoparticle
RP-56976
SDP-014
TXL
Taxotere
Taxotere (TN)
Taxotere(R)
XRP-6976L
docetaxel
docetaxel 114977-28-5
nchembio.188-comp8
nchembio.2007.34-comp7
nchembio.573-comp11
nchembio853-comp8
13Hormone AntagonistsPhase 212778
14glucocorticoidsPhase 24920
15HIV Protease InhibitorsPhase 25319
16Albumin-Bound PaclitaxelPhase 22757
17Gastrointestinal AgentsPhase 28109
18Antineoplastic Agents, PhytogenicPhase 25420
19
protease inhibitorsPhase 25320
Synonyms:
 
protease inhibitors
20Peripheral Nervous System AgentsPhase 222776
21Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 212767
22HormonesPhase 213979
23AnalgesicsPhase 211287
24valacyclovirPhase 1, Phase 2104
25VaccinesPhase 26428
26Dexamethasone acetatePhase 220841177-87-3
27Anti-Infective AgentsPhase 1, Phase 221402
28AcyclovirPhase 1, Phase 2178
29AntiemeticsPhase 2, Phase 13888
30Antiviral AgentsPhase 1, Phase 29732
31BB 1101Phase 22084
32Dexamethasone 21-phosphatePhase 22084
33Anti-Inflammatory AgentsPhase 210355
34Autonomic AgentsPhase 29774
35Antineoplastic Agents, HormonalPhase 25407
36Antimitotic AgentsPhase 25498
37Protein Kinase InhibitorsPhase 23612
38PONATINIB Phase 2
39MitogensPhase 2, Phase 11526
40Liver ExtractsPhase 1, Phase 23868
41tyrosineNutraceuticalPhase 1, Phase 2659
42
Neomycinapproved, vet_approvedPhase 1481404-04-28378
Synonyms:
(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside
(2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol
11025-81-3
119-04-0
1393-86-8
1404-04-2
1405-10-3 (sulfate (salt))
4-18-00-07476 (Beilstein Handbook Reference)
72131_FLUKA
AB00443887
AC1L1QVH
Actilin
Actiline
Antibiotic 10676
Antibiotic produced by Streptomyces decaris. Neomycin B
Antibiotique
BDG-(1-4)CYY-(5-1)RIB-(3-1)IDG
BDG-(1-4)NEB-(5-1)RIB-(3-1)NED
BPBio1_000326
BRN 0101621
BSPBio_000296
C01737
C23H46N6O13
C25H50N6O13
CCRIS 5462
CHEBI:7508
CID8378
Caswell No. 595
D-Streptamine, O-2,6-diamino-2,6-dideoxy-.beta.-L-idopyranosyl-(1.->3)-O-.beta.-D-ribofuranosyl-(1->5)]-O-[2,6-diamino-2,6-dideoxy-.alpha.-D-glucopyranosyl-(1->4)]-2-deoxy
D05140
DB00452
DB00994
EINECS 204-292-2
EINECS 215-766-3
EPA Pesticide Chemical Code 006303
Endomixin
Enterfram
Fradiomycin
Fradiomycin B
Fradiomycinum
Framicetina
Framicetina [INN-Spanish]
Framycetin
Framycetin (INN)
Framycetin [INN:BAN:DCF]
Framycetine
Framycetine [INN-French]
Framycetinum
Framycetinum [INN-Latin]
 
Framygen
Fraquinol
HMS2089P15
HSDB 3242
LS-96091
LS-96095
MolPort-003-938-736
Myacine
Myacyne
Mycifradin
Myciguent
N1142_SIGMA
NCGC00179612-01
NEOMYCIN AND POLYMYXIN B SULFATES
NEOMYCIN B
NEOMYCIN SULFATE
NMY
Neo-Fradin
Neo-Rx
Neobiotic
Neobrettin
Neolate
Neomas
Neomcin
Neomicina
Neomicina [DCIT]
Neomin
Neomycin B Sulfate
Neomycin B sulfate
Neomycin Sulfate
Neomycin Sulphate
Neomycin solution
Neomycine
Neomycine [INN-French]
Neomycinum
Neomycinum [INN-Latin]
Nivemycin
PIMAVECORT
Prestwick3_000158
ST075177
Soframycin
Soframycin Ophthalmic
Soframycine
Tuttomycin
UNII-4BOC774388
UNII-I16QD7X297
USAF CB-19
VONAMYCIN
Vonamycin powder V
neomycin
43
OndansetronapprovedPhase 130999614-02-54595
Synonyms:
(RS)-1,2,3,9-Tetrahydro-9-methyl-3-(2-methylimidazol-1-ylmethyl)carbazol-4-one
1,2,3,9-Tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-4H-carbazol-4-one
103639-04-9 (mono-hydrochloride dihydrate)
108303-49-7
116002-70-1
9-Methyl-3-(2-methyl-imidazol-1-ylmethyl)-1,2,3,9-tetrahydro-carbazol-4-one
9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-one
9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4-one
99614-01-4 (mono-hydrochloride)
99614-02-5
AB00373674
AC1L1IIM
AKOS000599484
Apo-ondansetron
BAS 00717177
BPBio1_001118
BRD-A19736161-001-01-8
BRD-A19736161-003-03-0
BRN 3622981
BSPBio_001016
C07325
C18H19N3O
CBDivE_008994
CHEMBL46
CID4595
CPD001307702
D00456
DB00904
DESMETHYLONDANSETRON
GR 38032
GR 38032X
GR-38032F
GR38032F
HMS2090H16
I06-0687
I06-1329
 
L000456
LS-172305
LS-51878
MolPort-001-944-253
NCI60_022780
Novo-ondansetron
Ondansetron
Ondansetron (JAN/USP/INN)
Ondansetron [USAN:INN:BAN]
Ondansetron, (+,-)-Isomer
Oprea1_435466
Oprea1_852372
PHL-ondansetron
PMS-ondansetron
Prestwick0_001058
Prestwick1_001058
Prestwick2_001058
Prestwick3_001058
Ratio-ondansetron
SAM002589958
SN-307
SPBio_002938
STK370548
STOCK4S-10990
Sandoz ondansetron
TL8006071
TimTec1_001750
UNII-4AF302ESOS
ZOFRAN IN PLASTIC CONTAINER
Zofran
Zofran ODT
Zofran ODT (TN)
Zofran odt
Zophren
Zudan
ondansetron
ondansetron (Zofran)
44
FludarabineapprovedPhase 1111321679-14-1, 75607-67-930751
Synonyms:
(2R,3S,4S,5R)-2-(6-amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
(2R,3S,4S,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
2-F-ARAA
2-F-ara-A
2-Fluoro Ara-A
2-Fluoro-9-beta-D-arabinofuranosyladenine
2-fluoro ARA-A
21679-14-1
9-beta-D-Arabinofuranosyl-2-fluoroadenine
9-beta-D-arabinofuranosyl-2-fluoro-9H-purin-6-amine
9H-Purin-6-amine, 9-beta-D-arabinofuranosyl-2-fluoro- (9CI)
AC1LCW8I
AC1Q51CF
C10H12FN5O4
CCRIS 3382
CHEMBL1568
CID657237
CPD000058874
D07966
EINECS 244-525-5
F-Ara-A
FAMP
FT-0082766
FaraA
Fludara
Fludara, Fludarabine
 
Fludarabina
Fludarabina [Spanish]
Fludarabine
Fludarabine (INN)
Fludarabine 5'-monophosphate
Fludarabine [INN]
Fludarabine monophosphate
Fludarabine phosphate
Fludarabinum
Fludarabinum [Latin]
Fludura
Fluradosa
Fluradosa (TN)
HSDB 6964
I14-4978
LS-15061
MLS000028687
NSC 118218
NSC 118218H
NSC-118218
S1491_Selleck
SAM002548956
SMR000058874
SQ Fludarabine
UNII-1X9VK9O1SC
UNII-P2K93U8740
ZINC04216238
45
Cyclophosphamideapproved, investigationalPhase 1282950-18-0, 6055-19-22907
Synonyms:
(+-)-Cyclophosphamide
(-)-Cyclophosphamide
(RS)-Cyclophosphamide
1-(bis(2-chloroethyl)amino)-1-oxo-2-aza-5-oxaphosphoridine
1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin
2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide
4-Hydroxy-cyclophosphan-mamophosphatide
50-18-0
60007-95-6
6055-19-2 (monohydrate)
75526-90-8
AC1L1EQQ
AI3-26198
ASTA
ASTA B518
Anhydrous cyclophosphamide
Asta B 518
B 518
B-518
BRN 0011744
BSPBio_002099
Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester
C 0768
C07888
C7H15Cl2N2O2P
CB 4564
CB-4564
CCRIS 188
CHEBI:4027
CHEMBL32520
CHEMBL88
CID2907
CP
CPA
CTX
CY
Ciclofosfamida
Ciclofosfamida [INN-Spanish]
Ciclofosfamide
Ciclophosphamide
Ciclophosphamide [INN]
Clafen
Claphene
Cycloblastin
Cyclophosphamid
Cyclophosphamide
Cyclophosphamide (INN)
Cyclophosphamide (TN)
Cyclophosphamide (anhydrous form)
Cyclophosphamide (anhydrous)
Cyclophosphamide Monohydrate
Cyclophosphamide Sterile
Cyclophosphamide anhydrous
Cyclophosphamide, (+-)-Isomer
Cyclophosphamides
Cyclophosphamidum
Cyclophosphamidum [INN-Latin]
Cyclophosphan
Cyclophosphane
Cyclophosphanum
Cyclophosphoramide
Cyclostin
Cyklofosfamid
Cyklofosfamid [Czech]
Cytophosphan
Cytophosphane
Cytoxan
Cytoxan (TN)
Cytoxan Lyoph
D,L-Cyclophosphamide
D07760
 
DB00531
DivK1c_000246
EINECS 200-015-4
EU-0100238
Endoxan
Endoxan R
Endoxan-Asta
Endoxana
Endoxanal
Endoxane
Enduxan
Genoxal
HMS2090A12
HSDB 3047
Hexadrin
IDI1_000246
KBio1_000246
KBio2_001338
KBio2_003906
KBio2_006474
KBio3_001319
KBioGR_000888
KBioSS_001338
LS-1302
LS-99787
Ledoxina
Lopac-C-0768
Lopac0_000238
Lyophilized Cytoxan
Mitoxan
MolPort-001-783-420
N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
NCGC00015209-01
NCGC00015209-03
NCGC00015209-06
NCGC00091741-02
NCGC00091741-03
NCI-C04900
NCI60_002097
NINDS_000246
NSC 26271
NSC-26271
NSC26271
NSC273033
NSC273034
Neosar
Occupation, cyclophosphamide exposure
Procytox
RCRA waste no. U058
Rcra Waste Number U058
Rcra waste number U058
Revimmune
S1217_Selleck
SK 20501
SPBio_001071
STK177249
STOCK2S-91217
Semdoxan
Sendoxan
Senduxan
Spectrum2_001146
Spectrum3_000370
Spectrum4_000304
Spectrum5_000795
Spectrum_000858
UNII-6UXW23996M
WLN: T6MPOTJ BO BN2G2G
Zyklophosphamid
Zyklophosphamid [German]
bis(2-Chloroethyl)phosphami de cyclic propanolamide
bis(2-Chloroethyl)phosphamide cyclic propanolamide ester
cyclophosphamide
46
Azacitidineapproved, investigationalPhase 1506320-67-29444
Synonyms:
2-(beta-D-Ribofuranosyl)-4-amino-1,3,5-triazin-2-one
320-67-2
4-Amino-1-(beta-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one
4-Amino-1-beta-D-ribofuranosyl-1,3,5-traizin-2(1H)-one
4-Amino-1-beta-D-ribofuranosyl-1,3,5-triazine-2(1H)-one
4-Amino-1-beta-D-ribofuranosyl-S-triazin-2(1H)-one
4-Amino-1-beta-D-ribofuranosyl-s-triazin-2(1H)-one
4-Amino-1-beta-d-ribofuranosyl-1,3,5-triazin-2(1H)-one
4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triaz
4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
4-amino-1-beta-L-ribofuranosyl-1,3,5-triazin-2(1H)-one
5 AZC
5 Azacytidine
5-AC
5-AZAC
5-AZCR
5-Azacytidine
5-aza-CR
5-azacitidine
5-azacytidine
5-azacytidine, Mylosar, Ladakamycin, Vidaza, Azacitidine
5AzaC
A 2385
A1287_SIGMA
A2385_SIGMA
AC1L1T1Y
Antibiotic U 18496
Azacitidina
Azacitidina [INN-Spanish]
Azacitidine
Azacitidine (JAN/USAN/INN)
Azacitidine [USAN:INN]
Azacitidinum
Azacitidinum [INN-Latin]
Azacytidine
BCBcMAP01_000083
BRN 0620461
BSPBio_003157
C11262
CCRIS 60
CHEBI:2038
CHEMBL1489
CID9444
CPD000857239
D001374
D03021
DB00928
DivK1c_000125
EINECS 206-280-2
EU-0100035
FT-0081170
HMS1921J22
HMS2092D08
HMS500G07
HSDB 6879
IDI1_000125
InChI=1/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1
 
Jsp005945
KBio1_000125
KBio2_001742
KBio2_002556
KBio2_004310
KBio2_005124
KBio2_006878
KBio2_007692
KBio3_002657
KBio3_003034
KBioGR_001444
KBioGR_002556
KBioSS_001742
KBioSS_002565
LS-1189
Ladakamycin
Lopac0_000035
MLS001333121
MLS001333122
MLS002153249
MolMap_000062
Mylosar
NCGC00090851-01
NCGC00090851-02
NCGC00090851-03
NCGC00090851-04
NCGC00090851-08
NCGC00178234-01
NCI-C01569
NINDS_000125
NS-17
NSC 102816
NSC-102816
NSC102816
Pharmion Brand of Azacitidine
S1782_Selleck
SAM002264595
SMR000857239
SPBio_000892
SPECTRUM1502111
ST056940
Spectrum2_000786
Spectrum3_001509
Spectrum4_000922
Spectrum5_001166
Spectrum_001262
TL80073599
U 18496
U-18496
UNII-M801H13NRU
Vidaza
Vidaza (TN)
WR-183027
ZINC03861768
cMAP_000082
mylo sar
pyrimidine antimetabolite: inhibits nucleic acid replication
s-Triazin-2(1H)-one, 4-amino-1-beta-D-ribofuranosyl- (8CI)
wr 183027
47
nivolumabapprovedPhase 1326946414-94-4
Synonyms:
BMS-936558
 
MDX-1106
ONO-4538
nivolumab
48Anti-Bacterial AgentsPhase 110884
49AntimetabolitesPhase 111774
50Immunosuppressive AgentsPhase 112770

Interventional clinical trials:

(show top 50)    (show all 56)
idNameStatusNCT IDPhase
1Acupuncture for Infectious Mononucleosis TrialCompletedNCT00598988Phase 2, Phase 3
2A Randomized Trial to Prevent Congenital Cytomegalovirus (CMV)RecruitingNCT01376778Phase 3
3Controlled Trial of Valacyclovir in Infectious MononucleosisCompletedNCT00274404Phase 1, Phase 2
4Activity of Valomaciclovir in Infectious Mononucleosis Due to Primary Epstein-Barr Virus InfectionCompletedNCT00575185Phase 1, Phase 2
5Evaluation of Safety, Immune-Response and Efficacy of GSK Biologicals’ EBV (Epstein Barr Virus) Vaccine (268664).CompletedNCT00430534Phase 2
6Accelerated Immunization to Induce Cytomegalovirus Immunity in Stem Cell DonorsCompletedNCT00353977Phase 2
7Carboplatin and Docetaxel Followed by Epstein-Barr Virus Cytotoxic T LymphocytesCompletedNCT00953420Phase 2
8Efficacy and Safety of AZD4547 Versus Paclitaxel in Advanced Gastric or Gastro-oesophageal Junction Cancer PatientsCompletedNCT01457846Phase 2
9Sedation Management in Pediatric Patients Supported on Mechanical VentilationCompletedNCT00142766Phase 2
10ARMS - Rapidly Generated Multivirus-Specific CTLs for the Prophylaxis And Treatment of EBV, CMV, Adenovirus, HHV6, and BK VirusRecruitingNCT01570283Phase 1, Phase 2
11Dovitinib for Gastric Cancer With FGFR2 AmplificationRecruitingNCT01719549Phase 2
12Ponatinib Hydrochloride in Treating Patients With Advanced Biliary Cancer With FGFR2 FusionsRecruitingNCT02265341Phase 2
13Phase 1/2 Study of ARQ 087 in Adult Subjects With Advanced Solid Tumors With FGFR Genetic AlterationsActive, not recruitingNCT01752920Phase 1, Phase 2
14A Phase II, Single Arm Study of BGJ398 in Patients With Advanced CholangiocarcinomaActive, not recruitingNCT02150967Phase 2
15Epstein Barr Virus (EBV) Specific Cytotoxic T-Cells, Relapsed Lymphoma, ANGELCompletedNCT00058617Phase 1
16T-Lymphocytes in Treating Patients With Epstein-Barr Virus-Positive Nasopharyngeal Cancer, NPCCompletedNCT00609219Phase 1
17LMP1- and LMP2-Specific CTLs to Patients With EBV-Positive NPC (NATELLA)CompletedNCT00516087Phase 1
18Treating Severe Chronic Epstein-Barr Virus (EBV) Infection With EBV Specific Cytotoxic T Lymphocytes (CTLs)CompletedNCT00058591Phase 1
19Administration of Rapidly Generated Multivirus-specific Cytotoxic T-Lymphocytes (VIRAGE)CompletedNCT01070797Phase 1
20Administration of Donor MultiTAA-Specific T Cells for ALLRecruitingNCT02475707Phase 1
21Administration of TAA-Specific CTLs; Hodgkin or Non-Hodgkin Lymphoma; TACTALRecruitingNCT01333046Phase 1
22Administration of Donor Multi TAA-Specific T Cells for AML or MDS (ADSPAM)RecruitingNCT02494167Phase 1
23Cytotoxic T Cells to Treat Relapsed EBV-positive LymphomaRecruitingNCT01956084Phase 1
24TGF-beta Resistant Cytotoxic T-lymphocytes in Treatment of EBV-positive Nasopharyngeal Carcinoma / RESIST-NPCRecruitingNCT02065362Phase 1
25Most Closely Matched 3rd Party Rapidly Generated LMP, BARF1 And EBNA1 Specific CTL, EBV-Positive Lymphoma (MABEL)RecruitingNCT02287311Phase 1
26Cytotoxic T-Lymphocytes for EBV-positive Lymphoma, GRALERecruitingNCT01555892Phase 1
27Most Closely HLA-Matched CTLs for Relapsed Epstein Barr Virus(EBV)-Associated DiseasesActive, not recruitingNCT01447056Phase 1
28LMP-specific T-cells for Patients With Relapsed EBV-positive LymphomaActive, not recruitingNCT00062868Phase 1
29T-cells or EBV Specific CTLs, Advanced B-Cell NHL and CLLActive, not recruitingNCT00709033Phase 1
30EBV CTLs Expressing CD30 Chimeric Receptors For CD 30+ LymphomaActive, not recruitingNCT01192464Phase 1
31Autologous/Allogeneic TGFbeta-resistant LMP2A-specific CTL, Lymphoma (TGF-beta)Active, not recruitingNCT00368082Phase 1
32Blood T-Cells and EBV Specific CTLs Expressing GD-2 Specific Chimeric T Cell Receptors to Neuroblastoma PatientsActive, not recruitingNCT00085930Phase 1
33Multi-virus CTLs Expressing CD19 Chimeric Receptors, CD19 Positive Malignancies Post SCT, MULTIPRATActive, not recruitingNCT00840853Phase 1
34Nivolumab With Epstein Barr Virus Specific T Cells (EB-VSTS), Relapsed/Refractory EBV Positive Lymphoma (PREVALE)Not yet recruitingNCT02973113Phase 1
35Giving Gene Marked EBV Specific T-Cells to Patients Receiving a BMT for Relapsed EBV-Positive Hodgkin DiseaseTerminatedNCT00058773Phase 1
36Lmp1 and Lmp2 Specific CTLs Following Cd45 Antibody for Relapsed Ebv-Positive Hodgkin's Or Non-Hodgkin's LymphomaTerminatedNCT00383097Phase 1
37LMP2a-Specific Cytotoxic T-Lymphocytes, Lymphoma (ACDAL)TerminatedNCT00082225Phase 1
38Phase I, Dose-escalation Trial of BAY1187982 in Subjects With Advanced Solid Tumors Known to Express Fibroblast Growth Factor Receptor 2 (FGFR2)TerminatedNCT02368951Phase 1
39HIV Indicator Diseases Across Europe StudyUnknown statusNCT01681706
40Genetic Studies of X-linked Lymphoproliferative DiseaseCompletedNCT00359411
41Prospective Study of Possible Infectious Disease - Associated Antigen Drive in Previously Untreated Indolent LymphomaCompletedNCT00582270
42Effects of Long-Term Treatment With Valaciclovir (Valtrex) on Epstein-Barr VirusCompletedNCT00005924
43Protein Studies of the Epstein-Barr Virus in Ethnically Diverse PopulationsCompletedNCT00070785
44Protein, Fiber, and Metabolic Syndrome - The PROFIMET StudyCompletedNCT00579657
45Effects of (1,3), (1,6)-Beta-D-glucan on Insulin Sensitivity and Inflammatory Markers of the Metabolic SyndromeCompletedNCT00403689
46Acute Effects of Glucose Dependent Insulinotropic Polypeptide (GIP) on Subcutaneous Adipose TissueCompletedNCT00774488
47Comparison of a Plant Protein Diet to a Animal Protein Diet Emphasized in Type 2 DiabeticsCompletedNCT02402985
48OPTIFIT-Optimal Fiber Trial for Diabetes PreventionCompletedNCT01681173
49Early ART Initiation Among HIV-positive Pregnant Women in Central MozambiqueCompletedNCT02371265
50The Use of Point-of-Care Ultrasound in the Diagnosis of Acute Infectious Mononucleosis in the Emergency DepartmentRecruitingNCT02463669

Search NIH Clinical Center for Pfeiffer Syndrome


Cochrane evidence based reviews: infectious mononucleosis

Genetic Tests for Pfeiffer Syndrome

About this section

Genetic tests related to Pfeiffer Syndrome:

id Genetic test Affiliating Genes
1 Pfeiffer Syndrome26

Anatomical Context for Pfeiffer Syndrome

About this section

MalaCards organs/tissues related to Pfeiffer Syndrome:

35
Bone, T cells, Eye, Monocytes, Testes, Spleen, Trachea

FMA organs/tissues related to Pfeiffer Syndrome:

17
Skull

Animal Models for Pfeiffer Syndrome or affiliated genes

About this section

MGI Mouse Phenotypes related to Pfeiffer Syndrome:

40 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.6COL1A1, FGF10, FGF8, FGFR1, FGFR2, FGFR3
2MP:00053808.6ALPL, COL1A1, FGF10, FGF8, FGFR1, FGFR2
3MP:00053918.6COL1A1, FGF10, FGF8, FGFR1, FGFR2, FGFR3
4MP:00053828.5ALPL, COL1A1, FGF10, FGF8, FGFR1, FGFR2
5MP:00028738.4COL1A1, FGF10, FGF8, FGFR1, FGFR2, FGFR3
6MP:00053698.3ALPL, COL1A1, COL3A1, FGF10, FGF8, FGFR1
7MP:00053718.2ALPL, COL1A1, FGF10, FGF8, FGFR1, FGFR2
8MP:00053888.1ALPL, COL1A1, COL3A1, FGF10, FGF8, FGFR2
9MP:00107717.9CD40LG, COL1A1, COL3A1, FGF10, FGF7, FGFR1
10MP:00053867.6ALPL, COL1A1, FGF10, FGF7, FGF8, FGFR1
11MP:00053797.5ALPL, CD40LG, COL1A1, FGF10, FGF8, FGFR1
12MP:00053897.5ALPL, CD40LG, COL1A1, FGF10, FGF7, FGF8
13MP:00053677.5CD40LG, COL1A1, CR2, FGF10, FGF7, FGF8
14MP:00053907.4ALPL, CD40LG, COL1A1, FGF10, FGF8, FGFR1
15MP:00053847.4ALPL, CD40LG, COL1A1, COL3A1, FGF10, FGF8
16MP:00053817.4ALPL, COL1A1, COL3A1, FGF10, FGF8, FGFR1
17MP:00036317.0ALPL, CD40LG, COL1A1, FGF10, FGF7, FGF8
18MP:00053856.6ALPL, CD40LG, COL1A1, COL3A1, FGF10, FGF8
19MP:00053786.5ALPL, COL1A1, COL3A1, FGF10, FGF8, FGFR1
20MP:00053765.9ALPL, CD40LG, COL1A1, COL3A1, CR2, FGF10
21MP:00053875.7ALPL, CD40LG, COL1A1, COL3A1, CR2, FGF10
22MP:00107685.7ALPL, CD40LG, COL1A1, COL3A1, CR2, FGF10
23MP:00053975.7ALPL, CD40LG, COL1A1, CR2, FGF10, FGF7

Publications for Pfeiffer Syndrome

About this section

Articles related to Pfeiffer Syndrome:

(show top 50)    (show all 115)
idTitleAuthorsYear
1
Pfeiffer syndrome: literature review of prenatal sonographic findings and genetic diagnosis. (27762162)
2016
2
Clinical Image - Radiographic manifestations in Pfeiffer syndrome. (25892094)
2015
3
Describing Crouzon and Pfeiffer syndrome based on principal component analysis. (25792443)
2015
4
Pfeiffer syndrome: Clinical and genetic findings in five Brazilian families. (25129254)
2014
5
Variable expressivity of pfeiffer syndrome in a family with FGFR1 p.Pro252Arg mutation. (25251565)
2014
6
Pfeiffer syndrome. (24891917)
2014
7
Pfeiffer syndrome with FGFR2 W290C mutation perinatally presenting extreme proptosis. (24411056)
2013
8
FGFR mutation in Pfeiffer syndrome. (23851850)
2013
9
Intubation using a "bonfils fiberscope" in a patient with pfeiffer syndrome. (23208638)
2011
10
Intestinal malrotation in a patient with Pfeiffer syndrome type 2. (20509766)
2010
11
A case of Pfeiffer syndrome with c833_834GC>TG (Cys278Leu) mutation in the FGFR2 gene. (21189955)
2010
12
Robinow syndrome, Cockayne syndrome, and Pfeiffer syndrome: an overview of physical, neurological, and oral characteristics. (20129888)
2010
13
Audiologic findings in Pfeiffer syndrome. (20856029)
2010
14
Q289P mutation in the FGFR2 gene: first report in a patient with type 1 Pfeiffer syndrome. (19066959)
2009
15
Pyrexia after transcranial surgery for Pfeiffer syndrome. (19242364)
2009
16
Pfeiffer syndrome twins: despite improved correction in one twin, growth disturbance results in similar need for subsequent monobloc advancement. (19390453)
2009
17
Pfeiffer syndrome with neonatal death secondary to tracheal obstruction owing to the FGFR2 Glu565Ala mutation. (18541976)
2008
18
A c.1019A > G mutation in FGFR2, which predicts p.Tyr340Cys, in a lethally malformed fetus with Pfeiffer syndrome and multiple pterygia. (18671283)
2008
19
A mutation in FGFR2 in a child with Pfeiffer syndrome and a sacral appendage. (18049087)
2008
20
Pfeiffer syndrome. (16740155)
2006
21
FGFR1 Pfeiffer syndrome without craniosynostosis: an additional case report. (16957473)
2006
22
A case of Pfeiffer syndrome. (16614535)
2006
23
Vertebral anomalies and cartilaginous tracheal sleeve in three patients with Pfeiffer syndrome carrying the S351C FGFR2 mutation. (15996217)
2005
24
Tracheal anomalies in Pfeiffer syndrome. (15545585)
2004
25
Novel mutation in the tyrosine kinase domain of FGFR2 in a patient with Pfeiffer syndrome. (15523615)
2004
26
The appearance of the feet in Pfeiffer syndrome caused by FGFR1 P252R mutation. (14564217)
2003
27
Severe and mild phenotypes in Pfeiffer syndrome with splice acceptor mutations in exon IIIc of FGFR2. (11807866)
2002
28
Pfeiffer syndrome type 2 associated with a single amino acid deletion in the FGFR2 gene. (10945669)
2000
29
Using three-dimensional ultrasound to detect craniosynostosis in a fetus with Pfeiffer syndrome. (11169319)
2000
30
Pfeiffer syndrome caused by haploinsufficient mutation of FGFR2. (10731087)
1999
31
Phenotype of the fibroblast growth factor receptor 2 Ser351Cys mutation: Pfeiffer syndrome type III. (9714439)
1998
32
Prenatal diagnosis of cloverleaf skull in the subtype 2 Pfeiffer syndrome. (9018425)
1997
33
Bilateral suprarenal cryptorchidism in a patient with the Pfeiffer syndrome. (9224373)
1997
34
Type 3 Pfeiffer syndrome with normal thumbs. (8958319)
1996
35
Mutations in FGFR1 and FGFR2 cause familial and sporadic Pfeiffer syndrome. (7795583)
1995
36
FGFR2 mutations in Pfeiffer syndrome. (7719333)
1995
37
Pfeiffer syndrome: a clinical review. (7727489)
1995
38
Hydrocephalus in pfeiffer syndrome. (18638762)
1994
39
Pfeiffer syndrome. (8054032)
1994
40
A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome. (7874169)
1994
41
A severe case of Pfeiffer syndrome associated with stub thumb on the maternal side of the family. (8325969)
1993
42
Pfeiffer syndrome update, clinical subtypes, and guidelines for differential diagnosis. (8434615)
1993
43
Natal molars in Pfeiffer syndrome type 3: a case report. (8110608)
1993
44
Pfeiffer syndrome: a syndrome of acrocephalosyndactyly. (1645001)
1992
45
Mild expression of the Pfeiffer syndrome. (3191611)
1988
46
Mild expression of the Pfeiffer syndrome. (3342547)
1988
47
Cloverleaf skull associated with Pfeiffer syndrome: pathology and management. (3792393)
1986
48
Variable expression in Pfeiffer syndrome. (7253005)
1981
49
Comparative dermatoglyphic analysis in two types of acrocephalosyndactyly: Saethre-Chotzen syndrome and Pfeiffer syndrome. (552891)
1979
50
Pfeiffer syndrome: an unusual type of acrocephalosyndactyl with broad thumbs and great toes. (5535071)
1970

Variations for Pfeiffer Syndrome

About this section

UniProtKB/Swiss-Prot genetic disease variations for Pfeiffer Syndrome:

69 (show all 19)
id Symbol AA change Variation ID SNP ID
1FGFR1p.Pro252ArgVAR_004111rs121909627
2FGFR2p.Ser252TrpVAR_004115rs79184941
3FGFR2p.Cys278PheVAR_004121rs776587763
4FGFR2p.Trp290CysVAR_004124rs121918499
5FGFR2p.Asp321AlaVAR_004129rs121918510
6FGFR2p.Thr341ProVAR_004135rs121918495
7FGFR2p.Cys342ArgVAR_004137rs121918488
8FGFR2p.Cys342SerVAR_004138rs121918488
9FGFR2p.Cys342TyrVAR_004139rs121918487
10FGFR2p.Ala344ProVAR_004141
11FGFR2p.Ser351CysVAR_004143rs121918502
12FGFR2p.Val359PheVAR_004146
13FGFR2p.Ala172PheVAR_017259
14FGFR2p.Tyr340CysVAR_017269
15FGFR2p.Cys342GlyVAR_017270
16FGFR2p.Tyr375CysVAR_017275rs121913478
17FGFR2p.Glu565GlyVAR_017277
18FGFR2p.Lys641ArgVAR_017278
19FGFR2p.Gly663GluVAR_017280

Clinvar genetic disease variations for Pfeiffer Syndrome:

5 (show all 14)
id Gene Variation Type Significance SNP ID Assembly Location
1FGFR2NM_000141.4(FGFR2): c.1025G> A (p.Cys342Tyr)SNVPathogenicrs121918487GRCh37Chr 10, 123276892: 123276892
2FGFR2NM_000141.4(FGFR2): c.1024T> C (p.Cys342Arg)SNVPathogenicrs121918488GRCh37Chr 10, 123276893: 123276893
3FGFR2NM_000141.4(FGFR2): c.1021A> C (p.Thr341Pro)SNVPathogenicrs121918495GRCh37Chr 10, 123276896: 123276896
4FGFR2NM_000141.4(FGFR2): c.870G> C (p.Trp290Cys)SNVPathogenicrs121918499GRCh37Chr 10, 123279562: 123279562
5FGFR2NM_000141.4(FGFR2): c.817_819delGAC (p.Asp273del)deletionPathogenicrs121918503GRCh37Chr 10, 123279613: 123279615
6FGFR2NM_000141.4(FGFR2): c.799T> C (p.Ser267Pro)SNVPathogenicrs121918505GRCh37Chr 10, 123279633: 123279633
7FGFR2NM_000141.4(FGFR2): c.940-1G> ASNVPathogenicrs879253719GRCh37Chr 10, 123276978: 123276978
8FGFR2NM_000141.4(FGFR2): c.940-3_946delinsACCindelPathogenicChr na, -1: -1
9FGFR2NM_000141.4(FGFR2): c.870G> T (p.Trp290Cys)SNVPathogenicrs121918499GRCh37Chr 10, 123279562: 123279562
10FGFR2NM_000141.4(FGFR2): c.1694A> C (p.Glu565Ala)SNVPathogenicrs121918506GRCh37Chr 10, 123256215: 123256215
11FGFR2NM_000141.4(FGFR2): c.1084+3A> GSNVPathogenicrs879253721GRCh38Chr 10, 121517316: 121517316
12FGFR2NM_000141.4(FGFR2): c.962A> C (p.Asp321Ala)SNVPathogenicrs121918510GRCh37Chr 10, 123276955: 123276955
13FGFR1NM_023110.2(FGFR1): c.755C> G (p.Pro252Arg)SNVPathogenicrs121909627GRCh37Chr 8, 38282208: 38282208
14FGFR2NM_000141.4(FGFR2): c.864_881del18 (p.Ile288_Val294delinsMet)deletionPathogenicrs886037837GRCh37Chr 10, 123279551: 123279568

Expression for genes affiliated with Pfeiffer Syndrome

About this section
Search GEO for disease gene expression data for Pfeiffer Syndrome.

Pathways for genes affiliated with Pfeiffer Syndrome

About this section

Pathways related to Pfeiffer Syndrome according to GeneCards Suite gene sharing:

(show all 36)
idSuper pathwaysScoreTop Affiliating Genes
19.9FGFR1, FGFR2, FGFR3
29.9FGFR1, FGFR2, FGFR3
3
Show member pathways
9.9FGFR1, FGFR2, FGFR3
49.7FGFR1, FGFR2, FGFR3, SH2D1A
59.6BGLAP, RUNX2, TWIST1
69.6FGF10, FGF8, FGFR1, FGFR3
79.5ALPL, FGFR1, FGFR3, RUNX2
89.5BGLAP, COL1A1, RUNX2
99.5BGLAP, FGFR1, FGFR2, RUNX2
109.4FGF8, FGFR1, FGFR2, FGFR3, TWIST1
119.4CD40LG, COL1A1, COL3A1
129.3FGF7, FGFR1, FGFR2, FGFR3
139.2CD40LG, CR2, TNFRSF8
14
Show member pathways
9.0FGF10, FGF7, FGF8, FGFR1, FGFR2
159.0BGLAP, COL1A1, FOSL1, RUNX2
168.9BGLAP, FGF10, FGF8, RUNX2, SP7
178.9CD40LG, COL3A1, TNFRSF8
18
Show member pathways
8.8FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
19
Show member pathways
8.8FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
20
Show member pathways
8.8FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
21
Show member pathways
8.8FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
228.8FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
23
Show member pathways
8.8FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
24
Show member pathways
8.8FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
258.8FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
26
Show member pathways
8.8FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
27
Show member pathways
8.8FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
288.8FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
298.8FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
30
Show member pathways
8.8FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
31
Show member pathways
8.6CD40LG, FGF10, FGF7, FGF8, FGFR1, FGFR2
328.4COL1A1, FGF10, FGF7, FGF8, FGFR1, FGFR2
33
Show member pathways
7.9COL1A1, COL3A1, FGF10, FGF7, FGF8, FGFR1
34
Show member pathways
7.7CD40LG, FGF10, FGF7, FGF8, FGFR1, FGFR2
35
Show member pathways
7.2CD40LG, FGF10, FGF7, FGF8, FGFR1, FGFR2
36
Show member pathways
6.3CD40LG, COL1A1, COL3A1, FGF10, FGF7, FGF8

GO Terms for genes affiliated with Pfeiffer Syndrome

About this section

Cellular components related to Pfeiffer Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.5ALPL, BGLAP, CD40LG, COL1A1, COL3A1, FGF10
2extracellular regionGO:00055767.2BGLAP, COL1A1, COL3A1, FGF10, FGF7, FGF8

Biological processes related to Pfeiffer Syndrome according to GeneCards Suite gene sharing:

(show all 50)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex developmentGO:003560710.9FGFR1, FGFR2
2mammary gland bud formationGO:006061510.8FGF10, FGFR2
3mesenchymal cell differentiation involved in lung developmentGO:006091510.8FGF10, FGFR2
4branch elongation involved in salivary gland morphogenesisGO:006066710.8FGF10, FGFR2
5fibroblast growth factor receptor signaling pathway involved in mammary gland specificationGO:006059510.8FGF10, FGFR2
6epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.7FGF10, FGFR2
7bud elongation involved in lung branchingGO:006044910.7FGF10, FGFR2
8ventricular zone neuroblast divisionGO:002184710.6FGFR1, FGFR2
9organ inductionGO:000175910.4FGF10, FGF8, FGFR1
10positive regulation of phospholipase activityGO:001051810.4FGFR1, FGFR2, FGFR3
11otic vesicle formationGO:003091610.4FGF10, FGF8, FGFR2
12glyceraldehyde-3-phosphate biosynthetic processGO:004616610.4TKT, TPI1
13secretion by lung epithelial cell involved in lung growthGO:006103310.4FGF10, FGF7
14regulation of odontogenesis of dentin-containing toothGO:004248710.3FGF8, RUNX2
15chondrocyte differentiationGO:000206210.3FGFR1, FGFR3, RUNX2
16bone mineralizationGO:003028210.3BGLAP, FGFR2, FGFR3
17embryonic cranial skeleton morphogenesisGO:004870110.2FGFR2, RUNX2, TWIST1
18regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:006066510.2FGF10, FGF7, FGFR1
19positive regulation of cell cycleGO:004578710.2FGFR1, FGFR2, FOSL1
20odontogenesisGO:004247610.0BGLAP, FGF8, FGFR2, TWIST1
21bone developmentGO:006034810.0BGLAP, FGF8, FGFR2, TWIST1
22lung developmentGO:003032410.0FGF10, FGF8, FGFR1, FGFR2
23inner ear morphogenesisGO:004247210.0FGF10, FGF8, FGFR1, FGFR2
24digestive tract developmentGO:004856510.0COL3A1, FGF10, FGFR2
25skeletal system morphogenesisGO:004870510.0COL1A1, FGFR1, FGFR2, RUNX2
26orbitofrontal cortex developmentGO:002176910.0FGFR1, FGFR2
27positive regulation of MAPK cascadeGO:004341010.0FGF10, FGFR1, FGFR2, FGFR3
28positive regulation of cell divisionGO:005178110.0FGF7, FGF8, FGFR2
29hair follicle morphogenesisGO:00310699.9FGF10, FGF7, FGFR2
30positive chemotaxisGO:00509189.9FGF10, FGF7, FGF8
31endochondral ossificationGO:00019589.7ALPL, COL1A1, FGFR3, RUNX2
32ossificationGO:00015039.7BGLAP, COL1A1, RUNX2, TWIST1
33regulation of immune responseGO:00507769.7CD40LG, COL1A1, COL3A1, SH2D1A
34positive regulation of epithelial cell proliferationGO:00506799.6FGF10, FGF7, FGFR2, TWIST1
35response to organic cyclic compoundGO:00140709.6BGLAP, FGF10, FGF8, FOSL1
36branching involved in salivary gland morphogenesisGO:00604459.5FGF10, FGF7, FGF8, FGFR1, FGFR2
37phosphatidylinositol-3-phosphate biosynthetic processGO:00360929.4FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
38phosphatidylinositol phosphorylationGO:00468549.4FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
39regulation of phosphatidylinositol 3-kinase signalingGO:00140669.4FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
40phosphatidylinositol-mediated signalingGO:00480159.3FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
41fibroblast growth factor receptor signaling pathwayGO:00085439.3FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
42positive regulation of ERK1 and ERK2 cascadeGO:00703749.3FGF10, FGF8, FGFR2, FGFR3
43peptidyl-tyrosine phosphorylationGO:00181089.3FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
44response to mechanical stimulusGO:00096129.1BGLAP, COL1A1, COL3A1, FOSL1
45MAPK cascadeGO:00001659.0FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
46positive regulation of GTPase activityGO:00435478.9FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
47osteoblast differentiationGO:00016498.8ALPL, BGLAP, COL1A1, RUNX2, SP7, TWIST1
48wound healingGO:00420608.8COL1A1, COL3A1, FGF10, FGF7
49skeletal system developmentGO:00015018.6ALPL, BGLAP, COL1A1, COL3A1, FGFR1, FGFR3
50positive regulation of cell proliferationGO:00082848.0FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3

Molecular functions related to Pfeiffer Syndrome according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor-activated receptor activityGO:000500710.5FGFR1, FGFR2, FGFR3
2type 2 fibroblast growth factor receptor bindingGO:000511110.3FGF10, FGF7
3fibroblast growth factor bindingGO:001713410.0FGFR1, FGFR2, FGFR3
4platelet-derived growth factor bindingGO:00484079.9COL1A1, COL3A1
5chemoattractant activityGO:00420569.5FGF10, FGF7, FGF8
6heparin bindingGO:00082019.3FGF10, FGF7, FGFR1, FGFR2
71-phosphatidylinositol-3-kinase activityGO:00163039.3FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
8phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:00469349.2FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
9Ras guanyl-nucleotide exchange factor activityGO:00050888.8FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
10protein tyrosine kinase activityGO:00047138.5FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3

Sources for Pfeiffer Syndrome

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet