PS
MCID: PFF001
MIFTS: 73

Pfeiffer Syndrome (PS) malady

Categories: Genetic diseases, Rare diseases, Infectious diseases, Eye diseases, Bone diseases, Fetal diseases, Skin diseases, Endocrine diseases

Aliases & Classifications for Pfeiffer Syndrome

About this section
Sources:
2CDC, 11Disease Ontology, 12diseasecard, 13DISEASES, 25Genetics Home Reference, 27GTR, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 36MalaCards, 37MedGen, 38MedlinePlus, 39MeSH, 40MESH via Orphanet, 45NCIt, 48NIH Rare Diseases, 50Novoseek, 52OMIM, 54Orphanet, 62SNOMED-CT, 64The Human Phenotype Ontology, 68UMLS, 69UMLS via Orphanet, 70UniProtKB/Swiss-Prot, 71Wikipedia
See all MalaCards sources

Aliases & Descriptions for Pfeiffer Syndrome:

Name: Pfeiffer Syndrome 52 36 11 71 48 25 54 70 12 50 13 68
Infectious Mononucleosis 36 11 50 38 2 39 13 68
Acs5 48 25 54 70
Craniofacial-Skeletal-Dermatologic Dysplasia 52 25 12
Acrocephalosyndactyly Type 5 48 54 70
Pfeiffer Type Acrocephalosyndactyly 48 68
Pfeiffer's Disease 11 27
Acs V 25 70
Gammaherpesviral Mononucleosis 11
 
Acrocephalosyndactylia Type V 11
Acrocephalosyndactyly, Type V 25
Acrocephalosyndactyly, Type 5 48
Filatov's Disease 11
Monocytic Angina 11
Glandular Fever 11
Noack Syndrome 25
Mononucleosis 11
Ps 70

Characteristics:

Orphanet epidemiological data:

54
pfeiffer syndrome:
Inheritance: Autosomal dominant; Prevalence: 1-9/100000 (Europe); Age of onset: Antenatal,Neonatal; Age of death: any age

HPO:

64
pfeiffer syndrome:
Inheritance: autosomal dominant inheritance

Classifications:



External Ids:

OMIM52 101600
Disease Ontology11 DOID:14705, DOID:8568
ICD1030 B27, B27.0, B27.9
ICD9CM32 075
Orphanet54 ORPHA710
ICD10 via Orphanet31 Q87.0
MESH via Orphanet40 C538582
UMLS via Orphanet69 C2931888

Summaries for Pfeiffer Syndrome

About this section
OMIM:52 Pfeiffer syndrome is an autosomal dominant craniosynostosis syndrome with characteristic anomalies of the hands and... (101600) more...

MalaCards based summary: Pfeiffer Syndrome, also known as infectious mononucleosis, is related to pharyngitis and pfeiffer syndrome type 1, and has symptoms including fever, pruritus and Array. An important gene associated with Pfeiffer Syndrome is FGFR2 (Fibroblast Growth Factor Receptor 2), and among its related pathways are Central carbon metabolism in cancer and Alzheimers Disease Pathway. Affiliated tissues include skull, bone and eye, and related mouse phenotypes are hearing/vestibular/ear and craniofacial.

Disease Ontology:11 An acrocephalosyndactylia that has material basis in mutations in the FGFR1 and FGFR2 gene which results in premature fusion located in skull.

Genetics Home Reference:25 Pfeiffer syndrome is a genetic disorder characterized by the premature fusion of certain skull bones (craniosynostosis). This early fusion prevents the skull from growing normally and affects the shape of the head and face. Pfeiffer syndrome also affects bones in the hands and feet.

NIH Rare Diseases:48 Pfeiffer syndrome is a disorder that affects the development of the bones in the skull, hands and feet. signs and symptoms can include craniosynostosis, which prevents normal skull growth and affects the shape of the head and face; distinctive facial features including bulging and wide-set eyes, a high forehead, an underdeveloped upper jaw, and a beaked nose; hearing loss; and dental problems. other features may include broad and deviated thumbs and great toes; brachydactyly; and syndactyly. it is caused by mutations in the fgfr1 or fgfr2 genes and is inherited in an autosomal dominant manner. pfeiffer syndrome is divided into 3 subtypes (type 1, type 2 and type 3) based on the presence and severity of specific features. management typically includes various surgical interventions. last updated: 7/12/2016

MedlinePlus:38 Infectious mononucleosis, or "mono", is an infection usually caused by the epstein-barr virus. the virus spreads through saliva, which is why it's sometimes called "kissing disease." mono occurs most often in teens and young adults. however, you can get it at any age. symptoms of mono include fever sore throat swollen lymph glands sometimes you may also have a swollen spleen. serious problems are rare. a blood test can show if you have mono. most people get better in two to four weeks. however, you may feel tired for a few months afterward. treatment focuses on helping symptoms and includes medicines for pain and fever, warm salt water gargles and plenty of rest and fluids.

CDC:2 Epstein-Barr virus, or EBV, is one of the most common human viruses in the world. It spreads primarily through saliva. EBV can cause infectious mononucleosis, also called mono, and other illnesses. Most people will get infected with EBV in their lifetime and will not have any symptoms. Mono caused by EBV is most common among teens and adults…

UniProtKB/Swiss-Prot:70 Pfeiffer syndrome: A syndrome characterized by the association of craniosynostosis, broad and deviated thumbs and big toes, and partial syndactyly of the fingers and toes. Three subtypes are known: mild autosomal dominant form (type 1); cloverleaf skull, elbow ankylosis, early death, sporadic (type 2); craniosynostosis, early demise, sporadic (type 3).

Wikipedia:71 Pfeiffer syndrome is a very rare genetic disorder characterized by the premature fusion of certain bones... more...

Related Diseases for Pfeiffer Syndrome

About this section

Diseases in the Pfeiffer Syndrome family:

Pfeiffer Syndrome Type 1 Pfeiffer Syndrome Type 1, 2 and 3
Pfeiffer Syndrome Type 3 Pfeiffer Syndrome Type 2

Diseases related to Pfeiffer Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 166)
idRelated DiseaseScoreTop Affiliating Genes
1pharyngitis30.0BGLAP, FGFR2, RUNX2, SP7
2pfeiffer syndrome type 111.9
3pfeiffer syndrome type 211.9
4pfeiffer syndrome type 311.8
5pfeiffer syndrome type 1, 2 and 311.8
6winkelman bethge pfeiffer syndrome11.7
7lymphoproliferative syndrome, x-linked, 111.6
8cytomegalovirus infection11.3
9cytomegalic inclusion disease11.2
10chronic active epstein-barr virus infection11.2
11scott syndrome11.0
12proteus syndrome, somatic11.0
13post-transplant lymphoproliferative disease10.9
14salivary gland disease10.9
15neurological consequences of cytomegalovirus infection10.9
16perlman syndrome10.8
17polydactyly, preaxial type ii10.8
18pituitary hormone deficiency, combined, 310.7
19ulna and fibula, hypoplasia of10.7
20pkp1-related ectodermal dysplasia/skin fragility syndrome10.3FGFR1, FGFR2
21pitx3-related anterior segment mesenchymal dysgenesis10.3FGFR1, FGFR2
22familial porphyria cutanea tarda10.3FGFR1, FGFR2, FGFR3
23hartsfield syndrome10.3FGFR1, FGFR2, FGFR3
24osteoglophonic dysplasia10.3FGFR1, FGFR2, FGFR3
25lymphoma10.3
26crouzon syndrome with acanthosis nigricans10.3FGFR1, FGFR2, FGFR3
27apert syndrome10.2FGFR1, FGFR2, FGFR3
28maroteaux stanescu cousin syndrome10.2ALPL, BGLAP, RUNX2
29thanatophoric dysplasia, type i10.2FGFR1, FGFR2, FGFR3
30deafness, autosomal recessive 6110.2ALPL, COL1A1, FGFR3
31mental retardation, autosomal recessive 3510.2BGLAP, COL1A1, FGFR3
32t cell immunodeficiency primary10.2COL1A1, FGFR1, FGFR3, RUNX2
33hepatitis10.2
34candidiasis, familial, 310.2FGF8, FGFR3
35muenke syndrome10.2FGF8, FGFR2, FGFR3
36factor xiiia deficiency10.2COL1A1, COL3A1
37neuropathy, distal hereditary motor, type iia10.1COL1A1, COL3A1, FGFR3, RUNX2
38pointer syndrome10.1FGFR1, FGFR2, FGFR3, TWIST1
39idiopathic recurrent and disabling cutaneous herpes10.1FGFR3, TWIST1
40atrophy of testis10.1FGFR1, FGFR2, FGFR3, TWIST1
41dysbaric osteonecrosis10.1BGLAP, COL1A1, RUNX2, SP7
42ischemic bone disease10.1BGLAP, RUNX2, SP7
43prostatocystitis10.1BGLAP, COL1A1, FGFR3, SP7
44intrahepatic cholestasis10.1BGLAP, COL1A1, RUNX2
45isolated scaphocephaly10.1FGFR3, TWIST1
46tonsillitis10.1
47vulvovaginitis10.1ALPL, BGLAP, COL1A1, FGFR3, SP7
48splenic infarction10.1
49craniosynostosis10.0
50leukemia10.0

Graphical network of the top 20 diseases related to Pfeiffer Syndrome:



Diseases related to pfeiffer syndrome

Symptoms & Phenotypes for Pfeiffer Syndrome

About this section

Symptoms by clinical synopsis from OMIM:

101600

Clinical features from OMIM:

101600

Human phenotypes related to Pfeiffer Syndrome:

 54 64 (show all 46)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 open mouth64 54 Occasional (29-5%) HP:0000194
2 high palate64 54 Occasional (29-5%) HP:0000218
3 turricephaly64 54 Frequent (79-30%) HP:0000262
4 mandibular prognathia64 54 Occasional (29-5%) HP:0000303
5 hypertelorism64 54 Frequent (79-30%) HP:0000316
6 short philtrum64 54 Occasional (29-5%) HP:0000322
7 facial asymmetry64 54 Occasional (29-5%) HP:0000324
8 high forehead64 54 Frequent (79-30%) HP:0000348
9 wide nasal bridge64 54 Frequent (79-30%) HP:0000431
10 short neck64 54 Occasional (29-5%) HP:0000470
11 ptosis64 54 Very frequent (99-80%) HP:0000508
12 brachydactyly syndrome64 54 Frequent (79-30%) HP:0001156
13 hip dysplasia64 54 Occasional (29-5%) HP:0001385
14 hyperlordosis64 54 Occasional (29-5%) HP:0003307
15 clinodactyly of the 5th finger64 54 Frequent (79-30%) HP:0004209
16 short stature64 54 Occasional (29-5%) HP:0004322
17 synostosis of carpal bones64 54 Occasional (29-5%) HP:0005048
18 finger syndactyly64 54 Frequent (79-30%) HP:0006101
19 symphalangism affecting the phalanges of the hand64 54 Frequent (79-30%) HP:0009773
20 cheekbone underdevelopment54 Very frequent (99-80%)
21 broad thumb64 54 Very frequent (99-80%) HP:0011304
22 flat face64 54 Occasional (29-5%) HP:0012368
23 hydrocephalus64 HP:0000238
24 brachyturricephaly64 HP:0000244
25 hypoplasia of the maxilla64 HP:0000327
26 choanal stenosis64 HP:0000452
27 choanal atresia64 HP:0000453
28 strabismus64 HP:0000486
29 downslanted palpebral fissures64 HP:0000494
30 shallow orbits64 HP:0000586
31 dental crowding64 HP:0000678
32 syndactyly64 HP:0001159
33 intellectual disability64 HP:0001249
34 arnold-chiari malformation64 HP:0002308
35 cloverleaf skull64 HP:0002676
36 bronchomalacia64 HP:0002780
37 humeroradial synostosis64 HP:0003041
38 elbow ankylosis64 HP:0003070
39 short nose64 HP:0003196
40 short middle phalanx of toe64 HP:0003795
41 coronal craniosynostosis64 HP:0004440
42 depressed nasal bridge64 HP:0005280
43 cartilaginous trachea64 HP:0005347
44 shortening of all middle phalanges of the fingers64 HP:0006110
45 broad hallux64 HP:0010055
46 hypoplasia of the zygomatic bone64 HP:0010669

UMLS symptoms related to Pfeiffer Syndrome:


fever, pruritus

MGI Mouse Phenotypes related to Pfeiffer Syndrome according to GeneCards Suite gene sharing:

41 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.4COL1A1, FGF10, FGF8, FGFR1, FGFR2, FGFR3
2MP:00053828.8ALPL, COL1A1, FGF10, FGF8, FGFR1, FGFR2
3MP:00053808.6ALPL, COL1A1, FGF10, FGF8, FGFR1, FGFR2
4MP:00053758.2ALPL, COL1A1, COL3A1, FGF10, FGFR2, TKT
5MP:00053698.2ALPL, COL1A1, COL3A1, FGF10, FGF8, FGFR1
6MP:00053918.0COL1A1, FGF10, FGF7, FGF8, FGFR1, FGFR2
7MP:00053718.0ALPL, COL1A1, FGF10, FGF8, FGFR1, FGFR2
8MP:00053817.9ALPL, COL1A1, COL3A1, FGF10, FGF8, FGFR1
9MP:00028737.8COL1A1, FGF10, FGF8, FGFR1, FGFR2, FGFR3
10MP:00053887.8ALPL, COL1A1, COL3A1, FGF10, FGF8, FGFR2
11MP:00053677.7CD40LG, COL1A1, CR2, FGF10, FGF7, FGF8
12MP:00107717.7CD40LG, COL1A1, COL3A1, FGF10, FGF7, FGFR1
13MP:00053897.7ALPL, CD40LG, COL1A1, FGF10, FGF7, FGF8
14MP:00053797.3ALPL, CD40LG, COL1A1, FGF10, FGF8, FGFR1
15MP:00053847.3ALPL, CD40LG, COL1A1, COL3A1, FGF10, FGF8
16MP:00053857.0ALPL, CD40LG, COL1A1, COL3A1, FGF10, FGF8
17MP:00036317.0ALPL, CD40LG, COL1A1, FGF10, FGF7, FGF8
18MP:00053906.6ALPL, CD40LG, COL1A1, FGF10, FGF7, FGF8
19MP:00053786.1ALPL, COL1A1, COL3A1, FGF10, FGF7, FGF8
20MP:00053766.1ALPL, CD40LG, COL1A1, COL3A1, CR2, FGF10
21MP:00107685.8ALPL, CD40LG, COL1A1, COL3A1, CR2, FGF10
22MP:00053875.7ALPL, CD40LG, COL1A1, COL3A1, CR2, FGF10
23MP:00053975.3ALPL, CD40LG, COL1A1, CR2, FGF10, FGF7

Drugs & Therapeutics for Pfeiffer Syndrome

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Drugs for Pfeiffer Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 68)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Rho(D) Immune GlobulinPhase 3326
2AntibodiesPhase 3, Phase 16394
3ImmunoglobulinsPhase 3, Phase 16394
4Immunoglobulins, IntravenousPhase 3333
5Immunoglobulin GPhase 3275
6gamma-GlobulinsPhase 3326
7
Dexamethasoneapproved, investigational, vet_approvedPhase 2217150-02-25743
Synonyms:
(3H)-Dexamethasone
.delta.(sup 1)-9-.alpha.-Fluoro-16-.alpha.-methylcortisol
.gamma.corten
1-Dehydro-16.alpha.-methyl-9.alpha.-fluorohydrocortisone
1-Dehydro-16alpha -methyl-9alpha -fluorohydrocortisone
1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone
1-Dehydro-16α-methyl-9α-fluorohydrocortisone
137098-19-2
16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol
16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone
16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone
16-alpha-Methyl-9-alpha-fluoroprednisolone
16.alpha.-Methyl-9.alpha.-fluoro-1-dehydrocortisol
16.alpha.-Methyl-9.alpha.-fluoroprednisolone
16alpha -Methyl-9alpha -fluoro-1-dehydrocortisol
16alpha -Methyl-9alpha -fluoroprednisolone
16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol
16alpha-Methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone
16alpha-Methyl-9alpha-fluoroprednisolone
16α-Methyl-9α-fluoro-1-dehydrocortisol
23495-06-9
31375_FLUKA
46165_FLUKA
46165_RIEDEL
50-02-2
8054-59-9
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11alpha -methylpregna-1,4-diene-3,20-dione
9-Fluoro-16-methylprednisolone
9-alpha-Fluoro-16-alpha-methylprednisolone
9.alpha.-Fluoro-16.alpha.-methylprednisolone
906422-84-2
9A-FLUORO-16BETA-METHYLPREDNISOLONE
9alpha -Fluoro-16alpha -methylprednisolone
9alpha-Fluoro-16alpha-methylprednisolone
9alpha-fluoro-16alpha-methyl-Prednisolone
9α-Fluoro-16α-methylprednisolone
AC-11056
AC1L1L1H
AC1Q29DM
AI3-50934
Adexone
Aeroseb-D
Aeroseb-Dex
Aeroseb-dex
Ak Dex Oph Otic Soln 0.1%
Alcon Brand of Dexamethasone
Anaflogistico
Aphtasolon
Aphthasolone
Apo-dexamethasone
Auxiron
Azimycin (veterinary)
Azium
Azium (Veterinary)
Azium (veterinary)
BIDD:ER0494
BIDD:PXR0060
BRD-K38775274-001-02-3
BRD-K38775274-001-06-4
BSPBio_000995
Bisu DS
Bisu Ds
C15643
C22H29FO5
CCRIS 7067
CHEBI:41879
CHEMBL384467
CID5743
CPD-10549
CPD001227192
Calonat
Corson
Corsone
Cortisumman
D00292
D003907
D1756_SIGMA
D4902_SIGMA
D6645_SIGMA
D8893_SIGMA
D9184_SIGMA
DB01234
DEX
DEXA
DEXONE 0.5
DEXONE 0.75
DEXONE 1.5
DEXONE 4
DXM
DXMS
Decacort
Decacortin
Decaderm
Decadron
Decadron (TN)
Decadron Tablets, Elixir
Decadron, Dexamethasone
Decadron-LA
Decadron-La
Decagel
Decaject
Decaject L.A.
Decaject-L.A.
Decalix
Decameth
Decasone
Decaspray
Dectancyl
Dekacort
Delta1-9alpha-Fluoro-16alpha-methylcortisol
Deltafluorene
Dergramin
Deronil
Desadrene
Desametasone
Desametasone [DCIT]
Desametasone [Dcit]
Desamethasone
Desameton
Deseronil
Dex-Ide
Dex-ide
Dexa
Dexa Mamallet
Dexa mamallet
Dexa-Cortidelt
Dexa-Cortisyl
Dexa-Mamallet
Dexa-Scheroson
Dexa-Sine
Dexa-cortidelt
Dexa-cortisyl
Dexa-scheroson
Dexa-sine
Dexacen-4
Dexacidin
Dexacort
Dexacortal
Dexacortin
Dexadeltone
Dexafarma
Dexair
Dexalona
Dexaltin
Dexametasona
Dexametasona [INN-Spanish]
Dexametasone
 
Dexameth
Dexamethansone
Dexamethasone
Dexamethasone (JP15/USP/INN)
Dexamethasone Acetate
Dexamethasone Alcohol
Dexamethasone Base
Dexamethasone Intensol
Dexamethasone Sodium Phosphate
Dexamethasone [INN:BAN:JAN]
Dexamethasone alcohol
Dexamethasone base
Dexamethasone intensol
Dexamethasone-omega
Dexamethasonum
Dexamethasonum [INN-Latin]
Dexamethazone
Dexamonozon
Dexapolcort
Dexapos
Dexaprol
Dexason
Dexasone
Dexasone 0.5mg
Dexasone 0.75mg
Dexasone 4mg
Dexasporin
Dexinolon
Dexinoral
Dexone
Dexone 0.5
Dexone 0.75
Dexone 1.5
Dexone 4
Dexonium
Dexpak
Dextelan
Dezone
Dinormon
Dxms
ECR Brand of Dexamethasone
EINECS 200-003-9
FT-0080377
Fluormethylprednisolone
Fluormone
Fluorocort
Fortecortin
Foy Brand of Dexamethasone
Gammacorten
HL-dex
HMS1792A17
HMS1990A17
HMS2089N13
HSDB 3053
Hexadecadrol
Hexadrol
Hexadrol Elixir
Hexadrol Tablets
Hexadrol elixir
Hl-Dex
Hl-dex
I06-1196
ICN Brand of Dexamethasone
IontoDex
Isopto-Dex
Isopto-dex
LS-7300
Lokalison F
Lokalison f
Loverine
Luxazone
MK 125
MLS001055412
MLS001332507
MLS001332508
Maxidex
Maxidex Ont 0.1%
Maxidex Sus 0.1%
Maxitrol
Mediamethasone
Merck Brand of Dexamethasone
Merz Brand 1 of Dexamethasone
Merz Brand 2 of Dexamethasone
Methylfluorprednisolone
Mexidex
Millicorten
MolMap_000018
MolPort-003-846-433
Mymethasone
NCGC00091019-01
NCGC00091019-02
NCGC00091019-03
NCGC00091019-04
NCGC00091019-05
NCI60_003067
NSC 34521
NSC34521
Naquasone (veterinary)
Neomycin and polymyxin b sulfates and dexamethasone
Neomycin and polymyxin b sulphates and dexamethasone
OTO-104
Ocu-Trol
Ocu-trol
Oradexon
PHL-dexamethasone
PMS-dexamethasone
Pet Derm III
Pet Derm Iii
Pet derm III
Pet-Derm Iii
Pms Dexamethasone Elixir 0.5mg/5ml
Policort
Posurdex
Prednisolon F
Prednisolon f
Prednisolone F
Prednisolone f
Prodex
S1322_Selleck
SAM002548948
SGCUT00126
SK-Dexamethasone
SK-dexamethasone
SMP1_000092
SMR000857119
SMR001227192
ST50307091
Sandoz dexamethasone
Sk-Dexamethasone
Spectrum5_002019
Spoloven
Sunia Sol D
Sunia sol D
Superprednol
TL8003317
Tobradex
Tobramycin and dexamethasone
Tresaderm (veterinary)
Turbinaire
UNII-7S5I7G3JQL
Visumetazone
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ G1
ZINC03875332
alpha -Fluoro-16-alpha -methylcortisol
delta(Sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta1-9alpha-Fluoro-16alpha-methylcortisol
dexamethasone
nchembio809-comp2
to_000038
8
LenograstimapprovedPhase 21220135968-09-1
Synonyms:
G-CSF (CHO cell derived)
Glycosylated recombinant G-CSF
Glycosylated recombinant granulocyte colony stimulating factor
 
Granulocyte colony stimulating factor 3 (CHO cell derived)
Granulocyte colony-stimulating factor lenograstim
Lenograstim (genetical recombination)
Lenograstim rDNA
9
CarboplatinapprovedPhase 2205041575-94-410339178, 498142, 38904
Synonyms:
(SP-4-2)-diammine[cyclobutane-1,1-dicarboxylato(2-)-kappa(2)O,O']platinum
/h1-3H2,(H,7,8)(H,9,10)
/q
1,1-Cyclobutanedicarboxylate diammine platinum (II)
1,1-Cyclobutanedicarboxylate diammine platinum(II)
2*-1
2*1H2
41575-94-4
70903-55-8
AC-1457
AC1L8I6U
Ambap41575-94-4
BSPBio_003145
C 2538
C2043
C2538_SIGMA
C6H10N2O4Pt
CBDCA
CCRIS 3404
CHEBI:31355
CHEMBL1351
CHEMBL288376
CID10339178
CID2567
CID38904
CID426756
CID498142
CID5352133
CID6398587
CID6603770
Carbopaltin
Carboplatin
Carboplatin (JAN/USP/INN)
Carboplatin (USAN)
Carboplatin [USAN:INN:BAN:JAN]
Carboplatine
Carboplatine [French]
Carboplatino
Carboplatino [Spanish]
Carboplatinum
Carboplatinum [Latin]
Cbdca
Cyclobutane-1,1-dicarboxylate
D01363
DB00958
Diammine(1,1-cyclobutanedicarboxylato)platinum (II)
Diammine(cyclobutane-1,1-dicarboxylato(2-)-O,O')platinum
Diammine-1,1-cyclobutane dicarboxylate platinum II
DivK1c_000892
EINECS 255-446-0
EU-0100230
Ercar
HMS1921J16
HMS2090M05
HMS2092B22
HMS502M14
HSDB 6957
I14-2390
IDI1_000892
IUPAC: Azane
InChI=1/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6
 
JM 8
JM-8
KBio1_000892
KBio2_002009
KBio2_004577
KBio2_007145
KBio3_002645
KBioGR_000713
KBioSS_002009
LS-117689
Lopac-C-2538
Lopac0_000230
MolPort-003-665-501
MolPort-003-845-609
NCGC00015223-01
NCGC00093695-01
NCGC00094961-01
NCGC00094961-02
NCGC00094961-03
NCGC00162099-01
NCGC00162099-02
NCGC00167800-01
NCGC00178242-01
NINDS_000892
NSC 201345
NSC 241240
NSC-241240
NSC201345
NSC241240
Paraplatin
Paraplatin (TN)
Paraplatin, Carboplatin
Paraplatin-AQ
Platinum(+2) Cation
Platinum(II), (1, 1-cyclobutanedicar
Platinum, diammine(1,1-cyclobutanedicarboxylato(2-)-O,O')-, (SP-4-2)
Platinum, {diammine[1,1-cyclobut
S1215_Selleck
SPBio_000716
SPECTRUM1502106
Spectrum2_000898
Spectrum3_001503
Spectrum4_000337
Spectrum5_001094
Spectrum_001529
UNII-BG3F62OND5
azanide
carboplatin
cis -Diammine[1,1-cyclobutane-dicarboxylato] platinum
cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II)
cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(ii)
cis-Diamine(1,1-cyclobutanedicarboxylato)platinum(II)
cis-Diamine[1,1-cyclobutanedicarboxylato]platinum(II)
cis-Diammine(1,1-cyclobutanedicarboxylato) platinum
cis-Diammine(1,1-cyclobutanedicarboxylato)platinum
cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)
cis-Diammine(cyclobutanedicarboxylato)platinum II
cyclobutane-1,1-dicarboxylic acid
diammine[cyclobutane-1,1-dicarboxylato(2-)-k2O1,O1]platinum
nchembio.573-comp10
nchembio773-comp2
nchembio873-comp3
platinum(2+)
10
ponatinibapprovedPhase 232943319-70-824826799
Synonyms:
AP 24534
AP24534
 
Iclusig
Ponatinibum
ponatinib
11
Docetaxelapproved, investigational, Approved May 1996Phase 21967114977-28-5148124, 9877265
Synonyms:
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl (aR,bS)-b-[[(1,1-dimethylethoxy)carbonyl]amino]-a-hydroxybenzenepropanoate
(2alpha,5beta,7beta,10beta,13alpha)-4-(acetyloxy)-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
01885_FLUKA
114977-28-5
4-(Acetyloxy)-13alpha-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7beta,10beta-trihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate
4-(acetyloxy)-13alpha-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7beta,10beta-trihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate
AC-383
AC1L3WHJ
ANX-514
BIND-014
C11231
CHEBI:4672
CHEMBL92
CID148124
D07866
DB01248
Docetaxel
Docetaxel (INN)
Docetaxel anhydrous
Docetaxel, Trihydrate
EmDOC
 
HMS2089K08
InChI=1/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,5
MolPort-003-847-005
N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxel
N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol
N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxel
N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol
N-debenzoyl-N-Boc-10-deacetyl taxol
NSC-628503
PSMA-targeted docetaxel nanoparticle
RP-56976
SDP-014
TXL
Taxotere
Taxotere (TN)
Taxotere(R)
XRP-6976L
docetaxel
docetaxel 114977-28-5
nchembio.188-comp8
nchembio.2007.34-comp7
nchembio.573-comp11
nchembio853-comp8
12Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 213168
13Hormone AntagonistsPhase 213180
14glucocorticoidsPhase 25103
15Anti-Infective AgentsPhase 1, Phase 222062
16HIV Protease InhibitorsPhase 25470
17Peripheral Nervous System AgentsPhase 223689
18VaccinesPhase 26611
19AcyclovirPhase 1, Phase 2183
20AnalgesicsPhase 211733
21
protease inhibitorsPhase 25471
Synonyms:
 
protease inhibitors
22Gastrointestinal AgentsPhase 28402
23HormonesPhase 214415
24Antineoplastic Agents, HormonalPhase 25592
25Antimitotic AgentsPhase 25657
26Dexamethasone acetatePhase 221711177-87-3
27AntiemeticsPhase 2, Phase 14022
28Autonomic AgentsPhase 210150
29Anti-Inflammatory AgentsPhase 210729
30Antiviral AgentsPhase 1, Phase 29967
31BB 1101Phase 22171
32Dexamethasone 21-phosphatePhase 22171
33valacyclovirPhase 1, Phase 2106
34Protein Kinase InhibitorsPhase 23689
35MitogensPhase 2, Phase 11617
36PONATINIB Phase 2
37Liver ExtractsPhase 1, Phase 24067
38tyrosineNutraceuticalPhase 1, Phase 2699
39
Neomycinapproved, vet_approvedPhase 1501404-04-28378
Synonyms:
(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside
(2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol
11025-81-3
119-04-0
1393-86-8
1404-04-2
1405-10-3 (sulfate (salt))
4-18-00-07476 (Beilstein Handbook Reference)
72131_FLUKA
AB00443887
AC1L1QVH
Actilin
Actiline
Antibiotic 10676
Antibiotic produced by Streptomyces decaris. Neomycin B
Antibiotique
BDG-(1-4)CYY-(5-1)RIB-(3-1)IDG
BDG-(1-4)NEB-(5-1)RIB-(3-1)NED
BPBio1_000326
BRN 0101621
BSPBio_000296
C01737
C23H46N6O13
C25H50N6O13
CCRIS 5462
CHEBI:7508
CID8378
Caswell No. 595
D-Streptamine, O-2,6-diamino-2,6-dideoxy-.beta.-L-idopyranosyl-(1.->3)-O-.beta.-D-ribofuranosyl-(1->5)]-O-[2,6-diamino-2,6-dideoxy-.alpha.-D-glucopyranosyl-(1->4)]-2-deoxy
D05140
DB00452
DB00994
EINECS 204-292-2
EINECS 215-766-3
EPA Pesticide Chemical Code 006303
Endomixin
Enterfram
Fradiomycin
Fradiomycin B
Fradiomycinum
Framicetina
Framicetina [INN-Spanish]
Framycetin
Framycetin (INN)
Framycetin [INN:BAN:DCF]
Framycetine
Framycetine [INN-French]
Framycetinum
Framycetinum [INN-Latin]
 
Framygen
Fraquinol
HMS2089P15
HSDB 3242
LS-96091
LS-96095
MolPort-003-938-736
Myacine
Myacyne
Mycifradin
Myciguent
N1142_SIGMA
NCGC00179612-01
NEOMYCIN AND POLYMYXIN B SULFATES
NEOMYCIN B
NEOMYCIN SULFATE
NMY
Neo-Fradin
Neo-Rx
Neobiotic
Neobrettin
Neolate
Neomas
Neomcin
Neomicina
Neomicina [DCIT]
Neomin
Neomycin B Sulfate
Neomycin B sulfate
Neomycin Sulfate
Neomycin Sulphate
Neomycin solution
Neomycine
Neomycine [INN-French]
Neomycinum
Neomycinum [INN-Latin]
Nivemycin
PIMAVECORT
Prestwick3_000158
ST075177
Soframycin
Soframycin Ophthalmic
Soframycine
Tuttomycin
UNII-4BOC774388
UNII-I16QD7X297
USAF CB-19
VONAMYCIN
Vonamycin powder V
neomycin
40
nivolumabapprovedPhase 1424946414-94-4
Synonyms:
BMS-936558
 
MDX-1106
ONO-4538
nivolumab
41
Azacitidineapproved, investigationalPhase 1529320-67-29444
Synonyms:
2-(beta-D-Ribofuranosyl)-4-amino-1,3,5-triazin-2-one
320-67-2
4-Amino-1-(beta-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one
4-Amino-1-beta-D-ribofuranosyl-1,3,5-traizin-2(1H)-one
4-Amino-1-beta-D-ribofuranosyl-1,3,5-triazine-2(1H)-one
4-Amino-1-beta-D-ribofuranosyl-S-triazin-2(1H)-one
4-Amino-1-beta-D-ribofuranosyl-s-triazin-2(1H)-one
4-Amino-1-beta-d-ribofuranosyl-1,3,5-triazin-2(1H)-one
4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triaz
4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
4-amino-1-beta-L-ribofuranosyl-1,3,5-triazin-2(1H)-one
5 AZC
5 Azacytidine
5-AC
5-AZAC
5-AZCR
5-Azacytidine
5-aza-CR
5-azacitidine
5-azacytidine
5-azacytidine, Mylosar, Ladakamycin, Vidaza, Azacitidine
5AzaC
A 2385
A1287_SIGMA
A2385_SIGMA
AC1L1T1Y
Antibiotic U 18496
Azacitidina
Azacitidina [INN-Spanish]
Azacitidine
Azacitidine (JAN/USAN/INN)
Azacitidine [USAN:INN]
Azacitidinum
Azacitidinum [INN-Latin]
Azacytidine
BCBcMAP01_000083
BRN 0620461
BSPBio_003157
C11262
CCRIS 60
CHEBI:2038
CHEMBL1489
CID9444
CPD000857239
D001374
D03021
DB00928
DivK1c_000125
EINECS 206-280-2
EU-0100035
FT-0081170
HMS1921J22
HMS2092D08
HMS500G07
HSDB 6879
IDI1_000125
InChI=1/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1
 
Jsp005945
KBio1_000125
KBio2_001742
KBio2_002556
KBio2_004310
KBio2_005124
KBio2_006878
KBio2_007692
KBio3_002657
KBio3_003034
KBioGR_001444
KBioGR_002556
KBioSS_001742
KBioSS_002565
LS-1189
Ladakamycin
Lopac0_000035
MLS001333121
MLS001333122
MLS002153249
MolMap_000062
Mylosar
NCGC00090851-01
NCGC00090851-02
NCGC00090851-03
NCGC00090851-04
NCGC00090851-08
NCGC00178234-01
NCI-C01569
NINDS_000125
NS-17
NSC 102816
NSC-102816
NSC102816
Pharmion Brand of Azacitidine
S1782_Selleck
SAM002264595
SMR000857239
SPBio_000892
SPECTRUM1502111
ST056940
Spectrum2_000786
Spectrum3_001509
Spectrum4_000922
Spectrum5_001166
Spectrum_001262
TL80073599
U 18496
U-18496
UNII-M801H13NRU
Vidaza
Vidaza (TN)
WR-183027
ZINC03861768
cMAP_000082
mylo sar
pyrimidine antimetabolite: inhibits nucleic acid replication
s-Triazin-2(1H)-one, 4-amino-1-beta-D-ribofuranosyl- (8CI)
wr 183027
42
FludarabineapprovedPhase 1115421679-14-1, 75607-67-930751
Synonyms:
(2R,3S,4S,5R)-2-(6-amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
(2R,3S,4S,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
2-F-ARAA
2-F-ara-A
2-Fluoro Ara-A
2-Fluoro-9-beta-D-arabinofuranosyladenine
2-fluoro ARA-A
21679-14-1
9-beta-D-Arabinofuranosyl-2-fluoroadenine
9-beta-D-arabinofuranosyl-2-fluoro-9H-purin-6-amine
9H-Purin-6-amine, 9-beta-D-arabinofuranosyl-2-fluoro- (9CI)
AC1LCW8I
AC1Q51CF
C10H12FN5O4
CCRIS 3382
CHEMBL1568
CID657237
CPD000058874
D07966
EINECS 244-525-5
F-Ara-A
FAMP
FT-0082766
FaraA
Fludara
Fludara, Fludarabine
 
Fludarabina
Fludarabina [Spanish]
Fludarabine
Fludarabine (INN)
Fludarabine 5'-monophosphate
Fludarabine [INN]
Fludarabine monophosphate
Fludarabine phosphate
Fludarabinum
Fludarabinum [Latin]
Fludura
Fluradosa
Fluradosa (TN)
HSDB 6964
I14-4978
LS-15061
MLS000028687
NSC 118218
NSC 118218H
NSC-118218
S1491_Selleck
SAM002548956
SMR000058874
SQ Fludarabine
UNII-1X9VK9O1SC
UNII-P2K93U8740
ZINC04216238
43
OndansetronapprovedPhase 132699614-02-54595
Synonyms:
(RS)-1,2,3,9-Tetrahydro-9-methyl-3-(2-methylimidazol-1-ylmethyl)carbazol-4-one
1,2,3,9-Tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-4H-carbazol-4-one
103639-04-9 (mono-hydrochloride dihydrate)
108303-49-7
116002-70-1
9-Methyl-3-(2-methyl-imidazol-1-ylmethyl)-1,2,3,9-tetrahydro-carbazol-4-one
9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-one
9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4-one
99614-01-4 (mono-hydrochloride)
99614-02-5
AB00373674
AC1L1IIM
AKOS000599484
Apo-ondansetron
BAS 00717177
BPBio1_001118
BRD-A19736161-001-01-8
BRD-A19736161-003-03-0
BRN 3622981
BSPBio_001016
C07325
C18H19N3O
CBDivE_008994
CHEMBL46
CID4595
CPD001307702
D00456
DB00904
DESMETHYLONDANSETRON
GR 38032
GR 38032X
GR-38032F
GR38032F
HMS2090H16
I06-0687
I06-1329
 
L000456
LS-172305
LS-51878
MolPort-001-944-253
NCI60_022780
Novo-ondansetron
Ondansetron
Ondansetron (JAN/USP/INN)
Ondansetron [USAN:INN:BAN]
Ondansetron, (+,-)-Isomer
Oprea1_435466
Oprea1_852372
PHL-ondansetron
PMS-ondansetron
Prestwick0_001058
Prestwick1_001058
Prestwick2_001058
Prestwick3_001058
Ratio-ondansetron
SAM002589958
SN-307
SPBio_002938
STK370548
STOCK4S-10990
Sandoz ondansetron
TL8006071
TimTec1_001750
UNII-4AF302ESOS
ZOFRAN IN PLASTIC CONTAINER
Zofran
Zofran ODT
Zofran ODT (TN)
Zofran odt
Zophren
Zudan
ondansetron
ondansetron (Zofran)
44
Cyclophosphamideapproved, investigationalPhase 1293550-18-0, 6055-19-22907
Synonyms:
(+-)-Cyclophosphamide
(-)-Cyclophosphamide
(RS)-Cyclophosphamide
1-(bis(2-chloroethyl)amino)-1-oxo-2-aza-5-oxaphosphoridine
1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin
2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide
4-Hydroxy-cyclophosphan-mamophosphatide
50-18-0
60007-95-6
6055-19-2 (monohydrate)
75526-90-8
AC1L1EQQ
AI3-26198
ASTA
ASTA B518
Anhydrous cyclophosphamide
Asta B 518
B 518
B-518
BRN 0011744
BSPBio_002099
Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester
C 0768
C07888
C7H15Cl2N2O2P
CB 4564
CB-4564
CCRIS 188
CHEBI:4027
CHEMBL32520
CHEMBL88
CID2907
CP
CPA
CTX
CY
Ciclofosfamida
Ciclofosfamida [INN-Spanish]
Ciclofosfamide
Ciclophosphamide
Ciclophosphamide [INN]
Clafen
Claphene
Cycloblastin
Cyclophosphamid
Cyclophosphamide
Cyclophosphamide (INN)
Cyclophosphamide (TN)
Cyclophosphamide (anhydrous form)
Cyclophosphamide (anhydrous)
Cyclophosphamide Monohydrate
Cyclophosphamide Sterile
Cyclophosphamide anhydrous
Cyclophosphamide, (+-)-Isomer
Cyclophosphamides
Cyclophosphamidum
Cyclophosphamidum [INN-Latin]
Cyclophosphan
Cyclophosphane
Cyclophosphanum
Cyclophosphoramide
Cyclostin
Cyklofosfamid
Cyklofosfamid [Czech]
Cytophosphan
Cytophosphane
Cytoxan
Cytoxan (TN)
Cytoxan Lyoph
D,L-Cyclophosphamide
D07760
 
DB00531
DivK1c_000246
EINECS 200-015-4
EU-0100238
Endoxan
Endoxan R
Endoxan-Asta
Endoxana
Endoxanal
Endoxane
Enduxan
Genoxal
HMS2090A12
HSDB 3047
Hexadrin
IDI1_000246
KBio1_000246
KBio2_001338
KBio2_003906
KBio2_006474
KBio3_001319
KBioGR_000888
KBioSS_001338
LS-1302
LS-99787
Ledoxina
Lopac-C-0768
Lopac0_000238
Lyophilized Cytoxan
Mitoxan
MolPort-001-783-420
N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
NCGC00015209-01
NCGC00015209-03
NCGC00015209-06
NCGC00091741-02
NCGC00091741-03
NCI-C04900
NCI60_002097
NINDS_000246
NSC 26271
NSC-26271
NSC26271
NSC273033
NSC273034
Neosar
Occupation, cyclophosphamide exposure
Procytox
RCRA waste no. U058
Rcra Waste Number U058
Rcra waste number U058
Revimmune
S1217_Selleck
SK 20501
SPBio_001071
STK177249
STOCK2S-91217
Semdoxan
Sendoxan
Senduxan
Spectrum2_001146
Spectrum3_000370
Spectrum4_000304
Spectrum5_000795
Spectrum_000858
UNII-6UXW23996M
WLN: T6MPOTJ BO BN2G2G
Zyklophosphamid
Zyklophosphamid [German]
bis(2-Chloroethyl)phosphami de cyclic propanolamide
bis(2-Chloroethyl)phosphamide cyclic propanolamide ester
cyclophosphamide
45Anti-Bacterial AgentsPhase 111226
46AntimetabolitesPhase 112054
47Immunosuppressive AgentsPhase 113086
48Chelating AgentsPhase 11423
49Antirheumatic AgentsPhase 110956
50Antimetabolites, AntineoplasticPhase 17361

Interventional clinical trials:

(show top 50)    (show all 58)
idNameStatusNCT IDPhase
1Acupuncture for Infectious Mononucleosis TrialCompletedNCT00598988Phase 2, Phase 3
2A Randomized Trial to Prevent Congenital Cytomegalovirus (CMV)RecruitingNCT01376778Phase 3
3Controlled Trial of Valacyclovir in Infectious MononucleosisCompletedNCT00274404Phase 1, Phase 2
4Activity of Valomaciclovir in Infectious Mononucleosis Due to Primary Epstein-Barr Virus InfectionCompletedNCT00575185Phase 1, Phase 2
5Evaluation of Safety, Immune-Response and Efficacy of GSK Biologicals’ EBV (Epstein Barr Virus) Vaccine (268664).CompletedNCT00430534Phase 2
6Accelerated Immunization to Induce Cytomegalovirus Immunity in Stem Cell DonorsCompletedNCT00353977Phase 2
7Carboplatin and Docetaxel Followed by Epstein-Barr Virus Cytotoxic T LymphocytesCompletedNCT00953420Phase 2
8Sedation Management in Pediatric Patients Supported on Mechanical VentilationCompletedNCT00142766Phase 2
9ARMS - Rapidly Generated Multivirus-Specific CTLs for the Prophylaxis And Treatment of EBV, CMV, Adenovirus, HHV6, and BK VirusRecruitingNCT01570283Phase 1, Phase 2
10A Phase II, Single Arm Study of BGJ398 in Patients With Advanced CholangiocarcinomaRecruitingNCT02150967Phase 2
11Dovitinib for Gastric Cancer With FGFR2 AmplificationRecruitingNCT01719549Phase 2
12Ponatinib Hydrochloride in Treating Patients With Advanced Biliary Cancer With FGFR2 FusionsRecruitingNCT02265341Phase 2
13Phase 1/2 Study of ARQ 087 in Adult Subjects With Advanced Solid Tumors With FGFR Genetic AlterationsActive, not recruitingNCT01752920Phase 1, Phase 2
14Pan FGFR Kinase Inhibitor BGJ398 in Treating Patients With FGFR1-3 Translocated, Mutated, or Amplified Recurrent Head and Neck CancerNot yet recruitingNCT02706691Phase 2
15Epstein Barr Virus (EBV) Specific Cytotoxic T-Cells, Relapsed Lymphoma, ANGELCompletedNCT00058617Phase 1
16T-Lymphocytes in Treating Patients With Epstein-Barr Virus-Positive Nasopharyngeal Cancer, NPCCompletedNCT00609219Phase 1
17LMP1- and LMP2-Specific CTLs to Patients With EBV-Positive NPC (NATELLA)CompletedNCT00516087Phase 1
18Treating Severe Chronic Epstein-Barr Virus (EBV) Infection With EBV Specific Cytotoxic T Lymphocytes (CTLs)CompletedNCT00058591Phase 1
19Administration of Rapidly Generated Multivirus-specific Cytotoxic T-Lymphocytes (VIRAGE)CompletedNCT01070797Phase 1
20Administration of Donor MultiTAA-Specific T Cells for ALLRecruitingNCT02475707Phase 1
21Administration of TAA-Specific CTLs; Hodgkin or Non-Hodgkin Lymphoma; TACTALRecruitingNCT01333046Phase 1
22Administration of Donor Multi TAA-Specific T Cells for AML or MDS (ADSPAM)RecruitingNCT02494167Phase 1
23Cytotoxic T Cells to Treat Relapsed EBV-positive LymphomaRecruitingNCT01956084Phase 1
24Nivolumab With Epstein Barr Virus Specific T Cells (EB-VSTS), Relapsed/Refractory EBV Positive Lymphoma (PREVALE)RecruitingNCT02973113Phase 1
25Most Closely Matched 3rd Party Rapidly Generated LMP, BARF1 And EBNA1 Specific CTL, EBV-Positive Lymphoma (MABEL)RecruitingNCT02287311Phase 1
26Cytotoxic T-Lymphocytes for EBV-positive Lymphoma, GRALERecruitingNCT01555892Phase 1
27TGF-beta Resistant Cytotoxic T-lymphocytes in Treatment of EBV-positive Nasopharyngeal Carcinoma / RESIST-NPCActive, not recruitingNCT02065362Phase 1
28Most Closely HLA-Matched CTLs for Relapsed Epstein Barr Virus(EBV)-Associated DiseasesActive, not recruitingNCT01447056Phase 1
29LMP-specific T-cells for Patients With Relapsed EBV-positive LymphomaActive, not recruitingNCT00062868Phase 1
30T-cells or EBV Specific CTLs, Advanced B-Cell NHL and CLLActive, not recruitingNCT00709033Phase 1
31EBV CTLs Expressing CD30 Chimeric Receptors For CD 30+ LymphomaActive, not recruitingNCT01192464Phase 1
32Autologous/Allogeneic TGFbeta-resistant LMP2A-specific CTL, Lymphoma (TGF-beta)Active, not recruitingNCT00368082Phase 1
33Blood T-Cells and EBV Specific CTLs Expressing GD-2 Specific Chimeric T Cell Receptors to Neuroblastoma PatientsActive, not recruitingNCT00085930Phase 1
34Multi-virus CTLs Expressing CD19 Chimeric Receptors, CD19 Positive Malignancies Post SCT, MULTIPRATActive, not recruitingNCT00840853Phase 1
35Giving Gene Marked EBV Specific T-Cells to Patients Receiving a BMT for Relapsed EBV-Positive Hodgkin DiseaseTerminatedNCT00058773Phase 1
36Lmp1 and Lmp2 Specific CTLs Following Cd45 Antibody for Relapsed Ebv-Positive Hodgkin's Or Non-Hodgkin's LymphomaTerminatedNCT00383097Phase 1
37LMP2a-Specific Cytotoxic T-Lymphocytes, Lymphoma (ACDAL)TerminatedNCT00082225Phase 1
38Phase I, Dose-escalation Trial of BAY1187982 in Subjects With Advanced Solid Tumors Known to Express Fibroblast Growth Factor Receptor 2 (FGFR2)TerminatedNCT02368951Phase 1
39HIV Indicator Diseases Across Europe StudyUnknown statusNCT01681706
40Genetic Studies of X-linked Lymphoproliferative DiseaseCompletedNCT00359411
41Prospective Study of Possible Infectious Disease - Associated Antigen Drive in Previously Untreated Indolent LymphomaCompletedNCT00582270
42Effects of Long-Term Treatment With Valaciclovir (Valtrex) on Epstein-Barr VirusCompletedNCT00005924
43Protein Studies of the Epstein-Barr Virus in Ethnically Diverse PopulationsCompletedNCT00070785
44Protein, Fiber, and Metabolic Syndrome - The PROFIMET StudyCompletedNCT00579657
45Effects of (1,3), (1,6)-Beta-D-glucan on Insulin Sensitivity and Inflammatory Markers of the Metabolic SyndromeCompletedNCT00403689
46Acute Effects of Glucose Dependent Insulinotropic Polypeptide (GIP) on Subcutaneous Adipose TissueCompletedNCT00774488
47Comparison of a Plant Protein Diet to a Animal Protein Diet Emphasized in Type 2 DiabeticsCompletedNCT02402985
48OPTIFIT-Optimal Fiber Trial for Diabetes PreventionCompletedNCT01681173
49Early ART Initiation Among HIV-positive Pregnant Women in Central MozambiqueCompletedNCT02371265
50The Use of Point-of-Care Ultrasound in the Diagnosis of Acute Infectious Mononucleosis in the Emergency DepartmentRecruitingNCT02463669

Search NIH Clinical Center for Pfeiffer Syndrome


Cochrane evidence based reviews: infectious mononucleosis

Genetic Tests for Pfeiffer Syndrome

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Genetic tests related to Pfeiffer Syndrome:

id Genetic test Affiliating Genes
1 Pfeiffer Syndrome27

Anatomical Context for Pfeiffer Syndrome

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MalaCards organs/tissues related to Pfeiffer Syndrome:

36
Bone, Eye, Monocytes, Spleen, Testes, Trachea

FMA organs/tissues related to Pfeiffer Syndrome:

17
Skull

Publications for Pfeiffer Syndrome

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Articles related to Pfeiffer Syndrome:

(show top 50)    (show all 115)
idTitleAuthorsYear
1
Cochlear Implantation in a Patient With Pfeiffer Syndrome and Temporal Bone Vascular Anomalies. (26825670)
2016
2
Pfeiffer syndrome: literature review of prenatal sonographic findings and genetic diagnosis. (27762162)
2016
3
The ophthalmic sequelae of Pfeiffer syndrome and the long-term visual outcomes after craniofacial surgery. (27418250)
2016
4
Avoidance of a potential tracheoinnominate fistula by innominate artery re-implantation in a four year old girl with tracheostomy dependence and Pfeiffer syndrome. (26810298)
2016
5
Clinical Image - Radiographic manifestations in Pfeiffer syndrome. (25892094)
2015
6
FGFR2 mutation in a patient without typical features of Pfeiffer syndrome--The emerging role of combined NGS and phenotype based strategies. (26096994)
2015
7
A Delayed Finding of a Tracheal Cartilaginous Sleeve in a Patient with Pfeiffer Syndrome Type 2 and a Complex Airway History. (26230305)
2015
8
Describing Crouzon and Pfeiffer syndrome based on principal component analysis. (25792443)
2015
9
Premature Closure of the Spheno-occipital Synchondrosis in Pfeiffer Syndrome: A Link to Midface Hypoplasia. (24406578)
2014
10
Pfeiffer syndrome: the importance of prenatal diagnosis. (25183684)
2014
11
Pfeiffer syndrome. (24891917)
2014
12
Pfeiffer syndrome: Clinical and genetic findings in five Brazilian families. (25129254)
2014
13
Upper extremity anomalies in Pfeiffer syndrome and mutational correlations. (24776567)
2014
14
Variable expressivity of pfeiffer syndrome in a family with FGFR1 p.Pro252Arg mutation. (25251565)
2014
15
The fibroblast growth factor receptor 2 p.Ala172Phe mutation in Pfeiffer syndrome--history repeating itself. (23532954)
2013
16
Pfeiffer syndrome with FGFR2 W290C mutation perinatally presenting extreme proptosis. (24411056)
2013
17
Pfeiffer syndrome: analysis of a clinical series and development of a classification system. (23348287)
2013
18
Pfeiffer Syndrome Type 3, a rare and unusual Craniosynostosis: Case reports from Korle Bu Teaching Hospital, Accra,Ghana. (24122692)
2013
19
FGFR mutation in Pfeiffer syndrome. (23851850)
2013
20
FGFR1 and FGFR2 mutations in Pfeiffer syndrome. (23348274)
2013
21
Prenatal diagnosis of Pfeiffer syndrome prior to 20 weeks' gestation. (23550868)
2013
22
Variable expressivity and clinical heterogeneity can complicate the diagnosis and management of Pfeiffer syndrome. (24036790)
2013
23
Clinical expression in Pfeiffer syndrome type 2 and 3: surveillance in Japan. (22965899)
2012
24
Pfeiffer syndrome type II discovered perinatally: Report of an observation and review of the literature. (22921691)
2012
25
Unique airway finding in a case of Pfeiffer syndrome and its management. (21897525)
2011
26
Biological effect of resorbable plates on normal osteoblasts and osteoblasts derived from Pfeiffer syndrome. (21558934)
2011
27
Intubation using a "bonfils fiberscope" in a patient with pfeiffer syndrome. (23208638)
2011
28
Robinow syndrome, Cockayne syndrome, and Pfeiffer syndrome: an overview of physical, neurological, and oral characteristics. (20129888)
2010
29
A case report of a patient with Pfeiffer syndrome, an FGRF 2 mutation (Trp290Cys) and unique ocular anterior segment findings. (20809772)
2010
30
Audiologic findings in Pfeiffer syndrome. (20856029)
2010
31
A case of Pfeiffer syndrome with c833_834GC>TG (Cys278Leu) mutation in the FGFR2 gene. (21189955)
2010
32
Chiari type 1 malformation in an infant with type 2 Pfeiffer syndrome: further evidence of acquired pathogenesis. (20186072)
2010
33
Intestinal malrotation in a patient with Pfeiffer syndrome type 2. (20509766)
2010
34
Pyrexia after transcranial surgery for Pfeiffer syndrome. (19242364)
2009
35
Pfeiffer syndrome twins: despite improved correction in one twin, growth disturbance results in similar need for subsequent monobloc advancement. (19390453)
2009
36
Pfeiffer syndrome: a treatment evaluation. (19407629)
2009
37
Cleft palate in Pfeiffer syndrome. (19816260)
2009
38
Q289P mutation in the FGFR2 gene: first report in a patient with type 1 Pfeiffer syndrome. (19066959)
2009
39
Monoblock craniofacial internal distraction in a child with Pfeiffer syndrome: a case report. (18437024)
2008
40
High-grade vesicoureteral reflux in Pfeiffer syndrome. (18825630)
2008
41
A c.1019A > G mutation in FGFR2, which predicts p.Tyr340Cys, in a lethally malformed fetus with Pfeiffer syndrome and multiple pterygia. (18671283)
2008
42
Craniosynostosis and congenital tracheal anomalies in an infant with Pfeiffer syndrome carrying the W290C FGFR2 mutation. (18618990)
2008
43
A mutation in FGFR2 in a child with Pfeiffer syndrome and a sacral appendage. (18049087)
2008
44
Pfeiffer syndrome with neonatal death secondary to tracheal obstruction owing to the FGFR2 Glu565Ala mutation. (18541976)
2008
45
Papilledema in patients with Apert, Crouzon, and Pfeiffer syndrome: prevalence, efficacy of treatment, and risk factors. (18216676)
2008
46
Tracheal cartilaginous sleeve with cricoid cartilage involvement in Pfeiffer syndrome. (16633174)
2006
47
Pfeiffer syndrome. (16740155)
2006
48
FGFR1 Pfeiffer syndrome without craniosynostosis: an additional case report. (16957473)
2006
49
Mutation screening in patients with syndromic craniosynostoses indicates that a limited number of recurrent FGFR2 mutations accounts for severe forms of Pfeiffer syndrome. (16418739)
2006
50
Usefulness of magnetic resonance imaging for accurate diagnosis of Pfeiffer syndrome type II in utero. (16490997)
2006

Variations for Pfeiffer Syndrome

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UniProtKB/Swiss-Prot genetic disease variations for Pfeiffer Syndrome:

70 (show all 19)
id Symbol AA change Variation ID SNP ID
1FGFR1p.Pro252ArgVAR_004111rs121909627
2FGFR2p.Ser252TrpVAR_004115rs79184941
3FGFR2p.Cys278PheVAR_004121rs776587763
4FGFR2p.Trp290CysVAR_004124rs121918499
5FGFR2p.Asp321AlaVAR_004129rs121918510
6FGFR2p.Thr341ProVAR_004135rs121918495
7FGFR2p.Cys342ArgVAR_004137rs121918488
8FGFR2p.Cys342SerVAR_004138rs121918488
9FGFR2p.Cys342TyrVAR_004139rs121918487
10FGFR2p.Ala344ProVAR_004141
11FGFR2p.Ser351CysVAR_004143rs121918502
12FGFR2p.Val359PheVAR_004146
13FGFR2p.Ala172PheVAR_017259
14FGFR2p.Tyr340CysVAR_017269
15FGFR2p.Cys342GlyVAR_017270
16FGFR2p.Tyr375CysVAR_017275rs121913478
17FGFR2p.Glu565GlyVAR_017277
18FGFR2p.Lys641ArgVAR_017278
19FGFR2p.Gly663GluVAR_017280

Clinvar genetic disease variations for Pfeiffer Syndrome:

5 (show all 23)
id Gene Variation Type Significance SNP ID Assembly Location
1FGFR2NM_ 000141.4(FGFR2): c.1025G> A (p.Cys342Tyr)SNVPathogenic/ Likely pathogenicrs121918487GRCh37Chr 10, 123276892: 123276892
2FGFR2NM_ 000141.4(FGFR2): c.1024T> C (p.Cys342Arg)SNVPathogenicrs121918488GRCh37Chr 10, 123276893: 123276893
3FGFR2NM_ 000141.4(FGFR2): c.1024T> A (p.Cys342Ser)SNVPathogenicrs121918488GRCh37Chr 10, 123276893: 123276893
4FGFR2NM_ 000141.4(FGFR2): c.1021A> C (p.Thr341Pro)SNVPathogenicrs121918495GRCh37Chr 10, 123276896: 123276896
5FGFR2NM_ 000141.4(FGFR2): c.866A> C (p.Gln289Pro)SNVPathogenicrs121918497GRCh37Chr 10, 123279566: 123279566
6FGFR2NM_ 000141.4(FGFR2): c.870G> C (p.Trp290Cys)SNVPathogenic/ Likely pathogenicrs121918499GRCh37Chr 10, 123279562: 123279562
7FGFR2NM_ 000141.4(FGFR2): c.1052C> G (p.Ser351Cys)SNVPathogenicrs121918502GRCh37Chr 10, 123276865: 123276865
8FGFR2NM_ 000141.4(FGFR2): c.817_ 819delGAC (p.Asp273del)deletionPathogenicrs121918503GRCh37Chr 10, 123279613: 123279615
9FGFR2NM_ 000141.4(FGFR2): c.799T> C (p.Ser267Pro)SNVPathogenicrs121918505GRCh37Chr 10, 123279633: 123279633
10FGFR2NM_ 000141.4(FGFR2): c.940-1G> ASNVPathogenicrs879253719GRCh37Chr 10, 123276978: 123276978
11FGFR2NM_ 000141.4(FGFR2): c.940-3_ 946delinsACCindelPathogenic
12FGFR2NM_ 000141.4(FGFR2): c.870G> T (p.Trp290Cys)SNVPathogenicrs121918499GRCh37Chr 10, 123279562: 123279562
13FGFR2NM_ 000141.4(FGFR2): c.1694A> C (p.Glu565Ala)SNVPathogenic/ Likely pathogenicrs121918506GRCh37Chr 10, 123256215: 123256215
14FGFR2NM_ 000141.4(FGFR2): c.1084+3A> GSNVPathogenicrs879253721GRCh38Chr 10, 121517316: 121517316
15FGFR2NM_ 000141.4(FGFR2): c.962A> C (p.Asp321Ala)SNVPathogenicrs121918510GRCh37Chr 10, 123276955: 123276955
16FGFR1NM_ 023110.2(FGFR1): c.755C> G (p.Pro252Arg)SNVPathogenicrs121909627GRCh37Chr 8, 38282208: 38282208
17FGFR2NM_ 000141.4(FGFR2): c.864_ 881del18 (p.Ile288_ Val294delinsMet)deletionPathogenicrs886037837GRCh37Chr 10, 123279551: 123279568
18FGFR2NM_ 000141.4(FGFR2): c.833G> T (p.Cys278Phe)SNVPathogenicrs776587763GRCh37Chr 10, 123279599: 123279599
19FGFR2NM_ 022970.3(FGFR2): c.833_ 834delGCinsTA (p.Cys278Leu)indelLikely pathogenicrs1057519037GRCh37Chr 10, 123279598: 123279599
20FGFR2NM_ 000141.4(FGFR2): c.940-2A> GSNVPathogenicrs1057519041GRCh38Chr 10, 121517465: 121517465
21FGFR2NM_ 000141.4(FGFR2): c.1024T> G (p.Cys342Gly)SNVPathogenicrs121918488GRCh37Chr 10, 123276893: 123276893
22FGFR2NM_ 000141.4(FGFR2): c.1694A> G (p.Glu565Gly)SNVLikely pathogenicrs121918506GRCh37Chr 10, 123256215: 123256215
23FGFR2NM_ 000141.4(FGFR2): c.1922A> G (p.Lys641Arg)SNVLikely pathogenicrs1057519047GRCh37Chr 10, 123247569: 123247569

Expression for genes affiliated with Pfeiffer Syndrome

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Search GEO for disease gene expression data for Pfeiffer Syndrome.

Pathways for genes affiliated with Pfeiffer Syndrome

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Pathways related to Pfeiffer Syndrome according to GeneCards Suite gene sharing:

(show all 41)
idSuper pathwaysScoreTop Affiliating Genes
19.9FGFR1, FGFR2, FGFR3
29.9FGFR1, FGFR2, FGFR3
3
Show member pathways
9.9FGFR1, FGFR2, FGFR3
49.7BGLAP, COL1A1
59.7FGFR1, FGFR2, FGFR3, SH2D1A
69.7BGLAP, RUNX2, TWIST1
79.6ALPL, FGFR1, FGFR3, RUNX2
89.5FGF10, FGF8, FGFR1, FGFR3
99.5BGLAP, FGFR1, FGFR2, RUNX2
10
Show member pathways
9.5COL1A1, FGFR1, FGFR2, FGFR3
119.5BGLAP, COL1A1, RUNX2
129.4CD40LG, COL1A1, COL3A1
139.4FGF8, FGFR1, FGFR2, FGFR3, TWIST1
149.1CD40LG, CR2, TNFRSF8
159.0CD40LG, COL3A1, TNFRSF8
169.0BGLAP, COL1A1, FOSL1, RUNX2
178.8BGLAP, FGF10, FGF8, RUNX2, SP7
18
Show member pathways
8.7FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
19
Show member pathways
8.7FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
20
Show member pathways
8.7FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
21
Show member pathways
8.7FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
228.7FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
23
Show member pathways
8.7FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
24
Show member pathways
8.7FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
25
Show member pathways
8.7FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
26
Show member pathways
8.7FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
278.7FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
28
Show member pathways
8.7FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
29
Show member pathways
8.7FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
30
Show member pathways
8.7FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
31
Show member pathways
8.7FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
32
Show member pathways
8.7FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
33
Show member pathways
8.5FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
34
Show member pathways
8.5CD40LG, FGF10, FGF7, FGF8, FGFR1, FGFR2
358.3COL1A1, FGF10, FGF7, FGF8, FGFR1, FGFR2
36
Show member pathways
8.3CD40LG, FGF10, FGF7, FGF8, FGFR1, FGFR2
37
Show member pathways
7.9COL1A1, COL3A1, FGF10, FGF7, FGF8, FGFR1
38
Show member pathways
7.7CD40LG, FGF10, FGF7, FGF8, FGFR1, FGFR2
39
Show member pathways
7.4CD40LG, FGF10, FGF7, FGF8, FGFR1, FGFR2
40
Show member pathways
7.2CD40LG, FGF10, FGF7, FGF8, FGFR1, FGFR2
41
Show member pathways
6.3CD40LG, COL1A1, COL3A1, FGF10, FGF7, FGF8

GO Terms for genes affiliated with Pfeiffer Syndrome

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Cellular components related to Pfeiffer Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.0ALPL, BGLAP, CD40LG, COL1A1, COL3A1, FGF10

Biological processes related to Pfeiffer Syndrome according to GeneCards Suite gene sharing:

(show top 50)    (show all 71)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex developmentGO:003560710.9FGFR1, FGFR2
2lung-associated mesenchyme developmentGO:006048410.9FGFR1, FGFR2
3endochondral bone growthGO:000341610.9FGFR2, FGFR3
4mesenchymal cell differentiationGO:004876210.9FGFR1, FGFR2
5orbitofrontal cortex developmentGO:002176910.9FGFR1, FGFR2
6outer ear morphogenesisGO:004247310.8FGFR1, TWIST1
7branch elongation involved in salivary gland morphogenesisGO:006066710.8FGF10, FGFR2
8bud elongation involved in lung branchingGO:006044910.8FGF10, FGFR2
9epidermis morphogenesisGO:004873010.8FGF10, FGFR2
10epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.8FGF10, FGFR2
11fibroblast growth factor receptor signaling pathway involved in mammary gland specificationGO:006059510.8FGF10, FGFR2
12lacrimal gland developmentGO:003280810.8FGF10, FGFR2
13limb bud formationGO:006017410.8FGF10, FGFR2
14mammary gland bud formationGO:006061510.8FGF10, FGFR2
15mesenchymal cell differentiation involved in lung developmentGO:006091510.8FGF10, FGFR2
16organ growthGO:003526510.8FGF10, FGFR2
17generation of neuronsGO:004869910.8FGF8, FGFR1
18regulation of fibroblast growth factor receptor signaling pathwayGO:004003610.7FGFR2, RUNX2
19regulation of osteoblast differentiationGO:004566710.7FGFR2, RUNX2
20mesonephros developmentGO:000182310.7FGF10, FGF8
21regulation of odontogenesis of dentin-containing toothGO:004248710.6FGF8, RUNX2
22salivary gland morphogenesisGO:000743510.6FGF10, FGFR1
23chondrocyte differentiationGO:000206210.6FGFR1, FGFR3, RUNX2
24ventricular zone neuroblast divisionGO:002184710.6FGFR1, FGFR2
25embryonic cranial skeleton morphogenesisGO:004870110.6FGFR2, RUNX2, TWIST1
26positive regulation of phospholipase activityGO:001051810.6FGFR1, FGFR2, FGFR3
27glyceraldehyde-3-phosphate biosynthetic processGO:004616610.6TKT, TPI1
28pentose-phosphate shuntGO:000609810.5TKT, TPI1
29bone mineralizationGO:003028210.5BGLAP, FGFR2, FGFR3
30otic vesicle formationGO:003091610.5FGF10, FGF8, FGFR2
31organ inductionGO:000175910.5FGF10, FGF8, FGFR1
32positive regulation of DNA-templated transcription, initiationGO:200014410.5FOSL1, TWIST1
33positive regulation of epithelial cell proliferation involved in lung morphogenesisGO:006050110.4FGF7, FGFR2
34digestive tract developmentGO:004856510.3COL3A1, FGF10, FGFR2
35positive regulation of cell cycleGO:004578710.3FGFR1, FGFR2, FOSL1
36positive regulation of MAPK cascadeGO:004341010.3FGF10, FGFR1, FGFR2, FGFR3
37inner ear morphogenesisGO:004247210.3FGF10, FGF8, FGFR1, FGFR2
38lung developmentGO:003032410.3FGF10, FGF8, FGFR1, FGFR2
39positive regulation of keratinocyte migrationGO:005154910.3FGF10, FGF7
40positive regulation of keratinocyte proliferationGO:001083810.3FGF10, FGF7
41response to gravityGO:000962910.3BGLAP, FOSL1
42positive regulation of ERK1 and ERK2 cascadeGO:007037410.3FGF10, FGF8, FGFR2, FGFR3
43bone developmentGO:006034810.2BGLAP, FGF8, FGFR2, TWIST1
44secretion by lung epithelial cell involved in lung growthGO:006103310.2FGF10, FGF7
45odontogenesisGO:004247610.2BGLAP, FGF8, FGFR2, TWIST1
46hair follicle morphogenesisGO:003106910.2FGF10, FGF7, FGFR2
47endochondral ossificationGO:000195810.1ALPL, COL1A1, FGFR3, RUNX2
48positive regulation of cell divisionGO:005178110.1FGF7, FGF8, FGFR2
49in utero embryonic developmentGO:000170110.1FGFR1, FGFR2, FOSL1, TWIST1
50regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalingGO:006066510.1FGF10, FGF7, FGFR1

Molecular functions related to Pfeiffer Syndrome according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1fibroblast growth factor bindingGO:001713410.6FGFR1, FGFR2, FGFR3
2fibroblast growth factor-activated receptor activityGO:000500710.6FGFR1, FGFR2, FGFR3
3platelet-derived growth factor bindingGO:004840710.2COL1A1, COL3A1
4chemoattractant activityGO:004205610.0FGF10, FGF7, FGF8
5fibroblast growth factor receptor bindingGO:000510410.0FGF10, FGF7, FGF8
6transmembrane receptor protein tyrosine kinase activityGO:00047149.9FGFR1, FGFR2, FGFR3
7heparin bindingGO:00082019.8FGF10, FGF7, FGFR1, FGFR2
81-phosphatidylinositol-3-kinase activityGO:00163039.4FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
9phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:00469349.3FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
10protein tyrosine kinase activityGO:00047139.3FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3
11Ras guanyl-nucleotide exchange factor activityGO:00050889.2FGF10, FGF7, FGF8, FGFR1, FGFR2, FGFR3

Sources for Pfeiffer Syndrome

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet