MCID: PHC013
MIFTS: 42

Phaeochromocytoma malady

Cancer diseases category

Summaries for Phaeochromocytoma

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66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 A pheochromocytoma (from Greek phaios \"dark\", chroma \"color\", kytos \"cell\", -oma \"tumor\") or... more...

MalaCards: Phaeochromocytoma is related to paraganglioma and neurofibromatosis. An important gene associated with Phaeochromocytoma is SDHD (succinate dehydrogenase complex, subunit D, integral membrane protein), and among its related pathways are Citric acid cycle (TCA cycle) and Carbon metabolism. The compounds mibg and catecholamine have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, testes and thyroid.

Description from OMIM:48 171300

Aliases & Classifications for Phaeochromocytoma

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9Disease Ontology, 11DISEASES, 48OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

phaeochromocytoma 9 11


External Ids:

Disease Ontology9 DOID:0050771
OMIM48 171300

Related Diseases for Phaeochromocytoma

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18GeneCards, 19GeneDecks
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Diseases related to Phaeochromocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 91)
idRelated DiseaseScoreTop Affiliating Genes
1paraganglioma30.8PNMT, SDHB, SDHD, SDHAF2, SDHC, SCG2
2neurofibromatosis30.6SDHD, SDHB
3multiple endocrine neoplasia30.5SDHC, SDHD, SDHB, PNMT
4von hippel-lindau disease30.4PNMT, SDHB, SDHD, SDHC
5multiple endocrine neoplasia type 2a30.2SDHC, SDHD, SDHB
6pheochromocytoma29.9SDHD, SDHB
7hypertension10.5
8neuroblastoma10.4
9thyroiditis10.3
10ganglioneuroma10.2
11cushing's syndrome10.2
12malignant hypertension10.1
13myocardial infarction10.1
14renal cell carcinoma10.1
15headache10.1
16glomus tumor10.1SDHD, SDHB
17familial colorectal cancer10.1SDHD, SDHB
18neuronitis10.0
19cerebritis10.0
20familial medullary thyroid carcinoma10.0
21acute myocardial infarction10.0
22ganglioneuroblastoma10.0
23thunderclap headache10.0
24aneurysm10.0
25hypoxia10.0
26septic shock10.0
27carcinoid syndrome10.0PNMT, SDHD, SCG2
28nasopharynx carcinoma10.0SDHD, SDHC
29neuroendocrine tumor10.0SCG2, SDHD
30paraganglioma and gastric stromal sarcoma10.0SDHB, SDHD, SDHC
31carotid body tumor10.0SDHC, SDHD, SDHB
32gastrointestinal stromal tumor10.0SDHB, SDHC
33carney triad10.0SDHC, SDHD, SDHB
34chondroma10.0SDHB, SDHD, SDHC
35wermer syndrome10.0SDHB, SDHD, SDHC
36adrenal adenoma10.0SDHB, SDHD, SDHC
37hyperparathyroidism10.0SDHB, SDHD, SDHC
38hereditary paraganglioma-pheochromocytoma syndromes9.9SDHC, SDHAF2, SDHD, SDHB
39kidney cancer9.9NPPC, SDHC, SDHB
40hemangioma9.9SDHB, SDHD, SDHAF2, SDHC
41pancreatic mucinous cystadenoma9.9
42cystadenoma9.9
43newcastle disease9.9
44hypertensive encephalopathy9.9
45acromegaly9.9
46protein s deficiency9.9
47acute pyelonephritis9.9
48gastrinoma9.9
49prolactinoma9.9
50spindle cell sarcoma9.9

Graphical network of the top 20 diseases related to Phaeochromocytoma:



Diseases related to phaeochromocytoma

Symptoms for Phaeochromocytoma

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48OMIM
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Clinical features from OMIM:

171300

Drugs & Therapeutics for Phaeochromocytoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Phaeochromocytoma

Drug clinical trials:

Search ClinicalTrials for Phaeochromocytoma

Search NIH Clinical Center for Phaeochromocytoma

Search CenterWatch for Phaeochromocytoma

Genetic Tests for Phaeochromocytoma

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Anatomical Context for Phaeochromocytoma

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34MalaCards
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MalaCards organs/tissues related to Phaeochromocytoma:

34
Adrenal gland, Testes, Thyroid, Heart, Pituitary, Adipocyte, Spinal cord, Breast, Skin, Retina, Dorsal root ganglion, Adrenal cortex, Cortex

Animal Models for Phaeochromocytoma or affiliated genes

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Publications for Phaeochromocytoma

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53PubMed
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Articles related to Phaeochromocytoma:

(show top 50)    (show all 531)
idTitleAuthorsYear
1
Plasma-free vs deconjugated metanephrines for diagnosis of phaeochromocytoma. (23461656)
2013
2
Don't forget phaeochromocytoma in the differential diagnosis of thunderclap headache. (23390238)
2013
3
Biochemical diagnosis of phaeochromocytoma and paraganglioma. (24347425)
2013
4
Phaeochromocytoma masquerading as anxiety and depression. (23826457)
2013
5
Bilateral Laparoscopic adrenalectomy due to a phaeochromocytoma in Von Hippel-Lindau Syndrome: a technique with 4 trocars. (22591617)
2012
6
Adrenal haemangioblastoma presenting as phaeochromocytoma: a rare manifestation of extraneural hemangioblastoma. (22544391)
2012
7
Phaeochromocytoma -- a classic (but easily forgotten) cause of anxiety. (21687915)
2011
8
Vasopressin for the treatment of catecholamine-resistant hypotension during a phaeochromocytoma resection in a 6-year-old child. (20498605)
2010
9
Plasma metadrenalines in canine phaeochromocytoma. (20418521)
2010
10
Outcomes of minimally invasive surgery for phaeochromocytoma. (19566519)
2009
11
Charles Sugrue, M.D., of Cork (1775-1816) and the first description of a classical medical condition: phaeochromocytoma. (18415053)
2008
12
131I-MIBG therapy in metastatic phaeochromocytoma and paraganglioma. (18071700)
2008
13
Perioperative management of late metastasis of phaeochromocytoma in clavicle. (18228643)
2008
14
Cyclooxygenase-2 expression correlates with phaeochromocytoma malignancy: evidence for a Bcl-2-dependent mechanism. (17916073)
2007
15
Combined coronary artery bypass grafting and phaeochromocytoma excision. (17567351)
2007
16
Magnesium sulphate for phaeochromocytoma crisis. (17919224)
2007
17
Laparoscopic adrenalectomy --- is it any different in phaeochromocytoma and non-phaeochromocytoma? (17962126)
2007
18
MIBG-SPECT/CT-angiography with 3-D reconstruction of an extra-adrenal phaeochromocytoma with dissection of an aortic aneurysm. (17033846)
2007
19
Adrenal cystic phaeochromocytoma: a case report. (16915783)
2006
20
Hypertensive primary intraventricular hemorrhage due to a phaeochromocytoma. (16813639)
2006
21
Phaeochromocytoma, new genes and screening strategies. (17121518)
2006
22
Ruptured phaeochromocytoma--a lesson in acute abdomen. (12777662)
2003
23
An undiagnosed phaeochromocytoma of the urinary bladder. (12413271)
2002
24
Tumour angiogenesis and Ki-67 expression in phaeochromocytoma. (11251535)
2001
25
Treatment of metastatic carcinoid tumours, phaeochromocytoma, paraganglioma and medullary carcinoma of the thyroid with (131)I-meta-iodobenzylguanidine [(131)I-mIBG]. (11453952)
2001
26
Phaeochromocytoma diagnosed during labour. (11573679)
2001
27
Asymptomatic bladder phaeochromocytoma in a 7-year-old boy. (11903845)
2001
28
Metastatic phaeochromocytoma: risks of diagnostic needle puncture and treatment by arterial embolisation. (11317207)
2001
29
Anaesthetic management for caesarean section combined with removal of phaeochromocytoma. (9649999)
1998
30
Cyclic AMP agonists increase levels of insulin-like growth factor (IGF) binding protein-6 in PC12 rat phaeochromocytoma cells. (10984315)
1998
31
Phaeochromocytoma and hypotension. (9612468)
1998
32
Immediate early gene induction by natriuretic peptides in PC12 phaeochromocytoma and C6 glioma cells. (9080415)
1997
33
Hereditary caprine phaeochromocytoma. (9274150)
1997
34
Phaeochromocytoma in Northern Ireland: a 21 year review. (8908450)
1996
35
Giant phaeochromocytoma: case report. (8867505)
1996
36
A minimal CGRP gene promoter is inducible by nerve growth factor in adult rat dorsal root ganglion neurons but not in PC12 phaeochromocytoma cells. (7773437)
1995
37
Postural palpitations--a curious presentation of intrathoracic phaeochromocytoma. (7502292)
1995
38
Investigation of phaeochromocytoma. (8736265)
1995
39
Pitfalls in scanning for phaeochromocytoma. (7914586)
1994
40
High levels of expression of neuropeptide Y mRNA in human phaeochromocytomas. (7955545)
1994
41
Phaeochromocytoma and familial tumour syndromes. (7913426)
1994
42
Phaeochromocytoma presenting acutely as severe cardiac failure. (7921568)
1994
43
Phaeochromocytoma in a long-term haemodialysis patient; diagnosis and management. (8272234)
1993
44
Block of the L-type Ca2+ channel pore by external and internal Mg2+ in rat phaeochromocytoma cells. (8410712)
1993
45
Phaeochromocytoma crisis in Sipple's syndrome with intrauterine death and disseminated intravascular coagulation. (15636849)
1993
46
Phaeochromocytoma in multiple endocrine neoplasia type 2 A: survey of 100 cases. (8101147)
1993
47
Identification of a MAP kinase kinase kinase in phaeochromocytoma (PC12) cells. (1468586)
1992
48
Immunocytochemical demonstration of IGF-II immunoreactivity in human phaeochromocytoma and extra-adrenal abdominal paraganglioma. (1635001)
1992
49
Acro-osteolysis of the phalanges and phaeochromocytoma. (1637995)
1992
50
The incidence rate of phaeochromocytoma and Conn's syndrome in Denmark, 1977-1981. (3236322)
1988

Variations for Phaeochromocytoma

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Expression for genes affiliated with Phaeochromocytoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Phaeochromocytoma

Search GEO for disease gene expression data for Phaeochromocytoma.

Pathways for genes affiliated with Phaeochromocytoma

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51PathCards, 56Reactome, 39NCBI BioSystems Database, 31KEGG, 52PharmGKB
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Pathways related to Phaeochromocytoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
TCA cycle39
pyruvate decarboxylation to acetyl CoA39
NAD phosphorylation and dephosphorylation39
TCA Cycle39
conversion of glucose to acetyl CoA and entry into the TCA cycle39
9.0SDHC, SDHD, SDHB
2
Show member pathways
L-serine degradation39
pentose phosphate pathway (oxidative branch)39
formaldehyde oxidation II (glutathione-dependent)39
9.0SDHC, SDHD, SDHB
3
Show member pathways
8.5SDHB, SDHD, SDHC, MT-CO2
4
Show member pathways
Alzheimers Disease39
8.5MT-CO2, SDHC, SDHD, SDHB
5
Show member pathways
8.2SDHB, SDHD, SDHC, MT-CO2, PNMT

Compounds for genes affiliated with Phaeochromocytoma

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46Novoseek, 25HMDB, 12DrugBank, 30IUPHAR, 52PharmGKB
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Compounds related to Phaeochromocytoma according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1mibg4610.0SDHD, SDHB
2catecholamine469.7SDHD, SDHB, PNMT
3alpha-ketoglutarate469.6SDHB, EGLN2
4Fumaric acid259.3SDHC, SDHD, SDHB
5fumarate46 1210.3SDHC, SDHD, SDHB
6succinic acid30 25 1211.3SDHB, SDHD, SDHC
7iron-sulfur469.3SDHB, SDHD, SDHC
8ubiquinone469.3SDHB, SDHD, SDHC
9Sulfide259.3SDHC, SDHD, SDHB
10QH2259.3SDHB, SDHD, SDHC
11Ubiquinone Q2259.3SDHC, SDHD, SDHB
12Ubiquinone Q1259.3SDHC, SDHD, SDHB
13succinate469.3SDHC, SDHD, SDHB
14FAD259.2SDHB, SDHD, SDHC
15histamine46 30 2511.2PNMT, SCG2, NPPC
16acetylcholine46 52 30 25 1213.1NPPC, SCG2, PNMT
17norepinephrine46 25 1211.0PNMT, SDHB, SCG2, NPPC
18dopamine46 30 25 1211.9SCG2, SDHB, PNMT
19iron46 259.8SDHB, SDHD, SDHC, EGLN2
20superoxide46 259.8SCG2, SDHC, SDHB
21atp46 309.7NPPC, MT-CO2, SCG2, SDHB
22vegf468.5EGLN2, SCG2, SDHC, SDHB
23oxygen46 259.4SDHB, SDHD, SDHC, MT-CO2, EGLN2

GO Terms for genes affiliated with Phaeochromocytoma

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17Gene Ontology
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Cellular components related to Phaeochromocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.4NPPC, SCG2
2mitochondrial respiratory chain complex IIGO:0057499.0SDHC, SDHD, SDHB
3mitochondrial inner membraneGO:0057438.9SDHC, SDHD, SDHB
4mitochondrionGO:0057398.1SDHB, SDHD, SDHAF2, SDHC

Biological processes related to Phaeochromocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tricarboxylic acid cycleGO:0060999.1SDHC, SDHD, SDHB
2aerobic respirationGO:0090609.0SDHC, SDHB
3respiratory electron transport chainGO:0229049.0SDHC, SDHD, SDHB
4cellular metabolic processGO:0442378.9SDHB, SDHD, SDHC
5small molecule metabolic processGO:0442818.6SDHC, SDHD, SDHB, PNMT

Molecular functions related to Phaeochromocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ubiquinone bindingGO:0480399.5SDHD, SDHB
2succinate dehydrogenase activityGO:0001049.2SDHC, SDHD
3electron carrier activityGO:0090559.0SDHC, SDHD, SDHB

Products for genes affiliated with Phaeochromocytoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Phaeochromocytoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet