Aliases & Classifications for Phaeochromocytoma

About this section

Phaeochromocytoma, Aliases & Descriptions:

Name: Phaeochromocytoma 9 11


External Ids:

Disease Ontology9 DOID:0050771

Summaries for Phaeochromocytoma

About this section


Wikipedia:63 A pheochromocytoma (from Greek phaios \"dark\", chroma \"color\", kytos \"cell\", -oma \"tumor\") or... more...

MalaCards based summary: Phaeochromocytoma is related to neurofibromatosis and multiple endocrine neoplasia. An important gene associated with Phaeochromocytoma is SDHD (succinate dehydrogenase complex, subunit D, integral membrane protein), and among its related pathways are Citric acid cycle (TCA cycle) and Carbon metabolism. The compounds mibg and catecholamine have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, testes and thyroid.

Related Diseases for Phaeochromocytoma

About this section

Diseases related to Phaeochromocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1neurofibromatosis30.4SDHB, SDHD, SDHC
2multiple endocrine neoplasia30.3SDHC, SDHD, SDHB, PNMT
3pheochromocytoma30.2SDHD, SDHB
4von hippel-lindau syndrome30.2PNMT, SDHB, SDHD, SDHC
5paraganglioma30.1PNMT, SDHB, SDHD, SDHAF2, SDHC, SCG2
6neuroblastoma10.4
7thyroiditis10.3
8glomus tumor10.3SDHD, SDHB
9cushing's syndrome10.3
10ganglioneuroma10.3
11neurofibromatosis, type 110.2
12neurofibromatosis, type 210.2SDHD, SDHB
13myocardial infarction10.2
14renal cell carcinoma10.2
15malignant hypertension10.2
16headache10.2
17acute myocardial infarction10.1
18acromegaly10.1
19neuronitis10.1
20cerebritis10.1
21ganglioneuroblastoma10.1
22thunderclap headache10.1
23aneurysm10.1
24hypoxia10.1
25carcinoid syndrome10.0PNMT, SDHD, SCG2
26nasopharyngeal carcinoma10.0SDHD, SDHC
27neuroendocrine tumor10.0SCG2, SDHD
28paraganglioma and gastric stromal sarcoma10.0SDHB, SDHD, SDHC
29gastrointestinal stromal tumor10.0SDHB, SDHC
30paragangliomas 1, with or without deafness9.9SDHC, SDHD, SDHB
31carney triad9.9SDHC, SDHD, SDHB
32multiple endocrine neoplasia iia9.9SDHC, SDHD, SDHB
33chondroma9.9SDHB, SDHD, SDHC
34multiple endocrine neoplasia 19.9SDHB, SDHD, SDHC
35hepatocellular carcinoma9.9
36chondrosarcoma9.9
37obesity9.9
38adult respiratory distress syndrome9.9
39dilated cardiomyopathy9.9
40insulinoma9.9
41myasthenia gravis9.9
42somatostatinoma9.9
43pancreatic mucinous cystadenoma9.9
44cystadenoma9.9
45newcastle disease9.9
46hypertensive encephalopathy9.9
47protein s deficiency9.9
48acute pyelonephritis9.9
49gastrinoma9.9
50prolactinoma9.9

Graphical network of the top 20 diseases related to Phaeochromocytoma:



Diseases related to phaeochromocytoma

Symptoms for Phaeochromocytoma

About this section

Drugs & Therapeutics for Phaeochromocytoma

About this section

Drug clinical trials:

Search ClinicalTrials for Phaeochromocytoma

Search NIH Clinical Center for Phaeochromocytoma

Genetic Tests for Phaeochromocytoma

About this section

Anatomical Context for Phaeochromocytoma

About this section

MalaCards organs/tissues related to Phaeochromocytoma:

31
Adrenal gland, Testes, Thyroid, Heart, Pituitary, Cortex, Retina, Spinal cord, Adipocyte, Breast, Skin, Dorsal root ganglion, Adrenal cortex

Animal Models for Phaeochromocytoma or affiliated genes

About this section

Publications for Phaeochromocytoma

About this section

Articles related to Phaeochromocytoma:

(show top 50)    (show all 556)
idTitleAuthorsYear
1
Diagnosing phaeochromocytoma/paraganglioma in a patient presenting with critical illness: biochemistry versus imaging. (25683095)
2015
2
Diagnosis of extra-adrenal phaeochromocytoma after nephrectomy. (25140231)
2014
3
Anaesthetic management of a dopamine-secreting phaeochromocytoma in multiple endocrine neoplasia 2B syndrome. (24963196)
2014
4
Plasma-free vs deconjugated metanephrines for diagnosis of phaeochromocytoma. (23461656)
2013
5
Don't forget phaeochromocytoma in the differential diagnosis of thunderclap headache. (23390238)
2013
6
Biochemical diagnosis of phaeochromocytoma and paraganglioma. (24347425)
2013
7
Phaeochromocytoma masquerading as anxiety and depression. (23826457)
2013
8
Bilateral Laparoscopic adrenalectomy due to a phaeochromocytoma in Von Hippel-Lindau Syndrome: a technique with 4 trocars. (22591617)
2012
9
Adrenal haemangioblastoma presenting as phaeochromocytoma: a rare manifestation of extraneural hemangioblastoma. (22544391)
2012
10
Phaeochromocytoma -- a classic (but easily forgotten) cause of anxiety. (21687915)
2011
11
Vasopressin for the treatment of catecholamine-resistant hypotension during a phaeochromocytoma resection in a 6-year-old child. (20498605)
2010
12
Plasma metadrenalines in canine phaeochromocytoma. (20418521)
2010
13
Outcomes of minimally invasive surgery for phaeochromocytoma. (19566519)
2009
14
Charles Sugrue, M.D., of Cork (1775-1816) and the first description of a classical medical condition: phaeochromocytoma. (18415053)
2008
15
131I-MIBG therapy in metastatic phaeochromocytoma and paraganglioma. (18071700)
2008
16
Cyclooxygenase-2 expression correlates with phaeochromocytoma malignancy: evidence for a Bcl-2-dependent mechanism. (17916073)
2007
17
Combined coronary artery bypass grafting and phaeochromocytoma excision. (17567351)
2007
18
Magnesium sulphate for phaeochromocytoma crisis. (17919224)
2007
19
Laparoscopic adrenalectomy --- is it any different in phaeochromocytoma and non-phaeochromocytoma? (17962126)
2007
20
MIBG-SPECT/CT-angiography with 3-D reconstruction of an extra-adrenal phaeochromocytoma with dissection of an aortic aneurysm. (17033846)
2007
21
Adrenal cystic phaeochromocytoma: a case report. (16915783)
2006
22
Hypertensive primary intraventricular hemorrhage due to a phaeochromocytoma. (16813639)
2006
23
Phaeochromocytoma, new genes and screening strategies. (17121518)
2006
24
Retrospective analysis of abnormal 24-h urinary free catecholamine concentration in screening for phaeochromocytoma. (12803844)
2003
25
Ruptured phaeochromocytoma--a lesson in acute abdomen. (12777662)
2003
26
An undiagnosed phaeochromocytoma of the urinary bladder. (12413271)
2002
27
Tumour angiogenesis and Ki-67 expression in phaeochromocytoma. (11251535)
2001
28
Treatment of metastatic carcinoid tumours, phaeochromocytoma, paraganglioma and medullary carcinoma of the thyroid with (131)I-meta-iodobenzylguanidine [(131)I-mIBG]. (11453952)
2001
29
Phaeochromocytoma diagnosed during labour. (11573679)
2001
30
Asymptomatic bladder phaeochromocytoma in a 7-year-old boy. (11903845)
2001
31
Anaesthetic management for caesarean section combined with removal of phaeochromocytoma. (9649999)
1998
32
Cyclic AMP agonists increase levels of insulin-like growth factor (IGF) binding protein-6 in PC12 rat phaeochromocytoma cells. (10984315)
1998
33
Phaeochromocytoma and hypotension. (9612468)
1998
34
Immediate early gene induction by natriuretic peptides in PC12 phaeochromocytoma and C6 glioma cells. (9080415)
1997
35
Hereditary caprine phaeochromocytoma. (9274150)
1997
36
Phaeochromocytoma in Northern Ireland: a 21 year review. (8908450)
1996
37
Giant phaeochromocytoma: case report. (8867505)
1996
38
A minimal CGRP gene promoter is inducible by nerve growth factor in adult rat dorsal root ganglion neurons but not in PC12 phaeochromocytoma cells. (7773437)
1995
39
Postural palpitations--a curious presentation of intrathoracic phaeochromocytoma. (7502292)
1995
40
Investigation of phaeochromocytoma. (8736265)
1995
41
Pitfalls in scanning for phaeochromocytoma. (7914586)
1994
42
High levels of expression of neuropeptide Y mRNA in human phaeochromocytomas. (7955545)
1994
43
Phaeochromocytoma and familial tumour syndromes. (7913426)
1994
44
Phaeochromocytoma in a long-term haemodialysis patient; diagnosis and management. (8272234)
1993
45
Block of the L-type Ca2+ channel pore by external and internal Mg2+ in rat phaeochromocytoma cells. (8410712)
1993
46
Phaeochromocytoma crisis in Sipple's syndrome with intrauterine death and disseminated intravascular coagulation. (15636849)
1993
47
Phaeochromocytoma in multiple endocrine neoplasia type 2 A: survey of 100 cases. (8101147)
1993
48
Identification of a MAP kinase kinase kinase in phaeochromocytoma (PC12) cells. (1468586)
1992
49
Immunocytochemical demonstration of IGF-II immunoreactivity in human phaeochromocytoma and extra-adrenal abdominal paraganglioma. (1635001)
1992
50
The incidence rate of phaeochromocytoma and Conn's syndrome in Denmark, 1977-1981. (3236322)
1988

Variations for Phaeochromocytoma

About this section

Expression for genes affiliated with Phaeochromocytoma

About this section
Search GEO for disease gene expression data for Phaeochromocytoma.

Pathways for genes affiliated with Phaeochromocytoma

About this section

Pathways related to Phaeochromocytoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
TCA cycle36
pyruvate decarboxylation to acetyl CoA36
NAD phosphorylation and dephosphorylation36
TCA Cycle36
conversion of glucose to acetyl CoA and entry into the TCA cycle36
9.0SDHC, SDHB, SDHD
2
Show member pathways
L-serine degradation36
pentose phosphate pathway (oxidative branch)36
formaldehyde oxidation II (glutathione-dependent)36
9.0SDHB, SDHC, SDHD
3
Show member pathways
8.5SDHB, SDHD, SDHC, MT-CO2
4
Show member pathways
Alzheimers Disease36
8.5SDHB, SDHD, SDHC, MT-CO2
5
Show member pathways
8.2SDHC, SDHB, PNMT, MT-CO2, SDHD

Compounds for genes affiliated with Phaeochromocytoma

About this section
Sources:
43Novoseek, 24HMDB, 12DrugBank, 28IUPHAR, 49PharmGKB
See all sources

Compounds related to Phaeochromocytoma according to GeneCards Suite gene sharing:

(show all 23)
idCompoundScoreTop Affiliating Genes
1mibg4310.0SDHD, SDHB
2catecholamine439.7SDHD, SDHB, PNMT
3alpha-ketoglutarate439.6SDHB, EGLN2
4Fumaric acid249.3SDHC, SDHD, SDHB
5fumarate43 1210.3SDHC, SDHD, SDHB
6succinic acid28 24 1211.3SDHB, SDHD, SDHC
7iron-sulfur439.3SDHB, SDHD, SDHC
8ubiquinone439.3SDHB, SDHD, SDHC
9Sulfide249.3SDHC, SDHD, SDHB
10QH2249.3SDHB, SDHD, SDHC
11Ubiquinone Q2249.3SDHC, SDHD, SDHB
12Ubiquinone Q1249.3SDHC, SDHD, SDHB
13succinate439.3SDHC, SDHD, SDHB
14FAD249.2SDHB, SDHD, SDHC
15histamine43 28 2411.2PNMT, SCG2, NPPC
16acetylcholine43 49 28 24 1213.1NPPC, SCG2, PNMT
17norepinephrine43 24 1211.0PNMT, SDHB, SCG2, NPPC
18dopamine43 28 24 1211.9SCG2, SDHB, PNMT
19iron43 249.8SDHB, SDHD, SDHC, EGLN2
20superoxide43 249.8SCG2, SDHC, SDHB
21atp43 289.7NPPC, MT-CO2, SCG2, SDHB
22vegf438.5EGLN2, SCG2, SDHC, SDHB
23oxygen43 249.4SDHB, SDHD, SDHC, MT-CO2, EGLN2

GO Terms for genes affiliated with Phaeochromocytoma

About this section

Cellular components related to Phaeochromocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:00301419.4NPPC, SCG2
2mitochondrial respiratory chain complex IIGO:00057499.0SDHB, SDHD, SDHC
3mitochondrial inner membraneGO:00057438.9SDHB, SDHC, SDHD
4mitochondrionGO:00057398.1SDHC, SDHB, SDHD, SDHAF2

Biological processes related to Phaeochromocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tricarboxylic acid cycleGO:00060999.1SDHC, SDHD, SDHB
2aerobic respirationGO:00090609.0SDHC, SDHB
3respiratory electron transport chainGO:00229049.0SDHC, SDHD, SDHB
4cellular metabolic processGO:00442378.9SDHB, SDHD, SDHC
5small molecule metabolic processGO:00442818.6SDHC, SDHD, SDHB, PNMT

Molecular functions related to Phaeochromocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ubiquinone bindingGO:00480399.5SDHD, SDHB
2succinate dehydrogenase activityGO:00001049.2SDHC, SDHD
3electron carrier activityGO:00090559.0SDHC, SDHD, SDHB

Products for genes affiliated with Phaeochromocytoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Phaeochromocytoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet