MCID: PHC013
MIFTS: 43

Phaeochromocytoma malady

Cancer diseases category
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Summaries for Phaeochromocytoma

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Wikipedia:65 A pheochromocytoma (from Greek phaios \"dark\", chroma \"color\", kytos \"cell\", -oma \"tumor\") or... more...

MalaCards based summary: Phaeochromocytoma is related to paraganglioma and neurofibromatosis. An important gene associated with Phaeochromocytoma is SDHD (succinate dehydrogenase complex, subunit D, integral membrane protein), and among its related pathways are Citric acid cycle (TCA cycle) and Carbon metabolism. The compounds mibg and catecholamine have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, testes and thyroid.

Description from OMIM:46 171300

Aliases & Classifications for Phaeochromocytoma

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Phaeochromocytoma, Aliases & Descriptions:

Name: Phaeochromocytoma 8 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:0050771
OMIM46 171300

Related Diseases for Phaeochromocytoma

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Diseases related to Phaeochromocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 92)
idRelated DiseaseScoreTop Affiliating Genes
1paraganglioma31.5SDHD, SDHB
2neurofibromatosis30.8SDHD, SDHB
3multiple endocrine neoplasia30.4SDHC, SDHD, SDHB, PNMT
4pheochromocytoma30.2SDHD, SDHB
5von hippel-lindau disease30.2PNMT, SDHB, SDHD, SDHC
6multiple endocrine neoplasia type 2a30.1SDHC, SDHD, SDHB
7hypertension10.6
8neuroblastoma10.4
9thyroiditis10.3
10cushing's syndrome10.3
11ganglioneuroma10.3
12familial colorectal cancer10.2SDHD, SDHB
13myocardial infarction10.1
14renal cell carcinoma10.1
15malignant hypertension10.1
16headache10.1
17acute myocardial infarction10.1
18acromegaly10.1
19familial medullary thyroid carcinoma10.1
20neuronitis10.1
21cerebritis10.1
22ganglioneuroblastoma10.1
23thunderclap headache10.1
24aneurysm10.1
25hypoxia10.1
26septic shock10.1
27carcinoid syndrome10.0PNMT, SDHD, SCG2
28nasopharynx carcinoma10.0SDHD, SDHC
29neuroendocrine tumor10.0SCG2, SDHD
30paraganglioma and gastric stromal sarcoma10.0SDHB, SDHD, SDHC
31carotid body tumor10.0SDHC, SDHD, SDHB
32gastrointestinal stromal tumor10.0SDHB, SDHC
33carney triad10.0SDHC, SDHD, SDHB
34chondroma9.9SDHB, SDHD, SDHC
35wermer syndrome9.9SDHB, SDHD, SDHC
36adrenal cortical adenoma9.9SDHB, SDHD, SDHC
37adult respiratory distress syndrome9.9
38diabetes mellitus9.9
39dilated cardiomyopathy9.9
40hepatocellular carcinoma9.9
41insulinoma9.9
42myasthenia gravis9.9
43obesity9.9
44parkinson's disease9.9
45somatostatinoma9.9
46pancreatic mucinous cystadenoma9.9
47cystadenoma9.9
48newcastle disease9.9
49protein s deficiency9.9
50acute pyelonephritis9.9

Graphical network of the top 20 diseases related to Phaeochromocytoma:



Diseases related to phaeochromocytoma

Symptoms for Phaeochromocytoma

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Clinical features from OMIM:

171300

Drugs & Therapeutics for Phaeochromocytoma

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Drug clinical trials:

Search ClinicalTrials for Phaeochromocytoma

Search NIH Clinical Center for Phaeochromocytoma

Genetic Tests for Phaeochromocytoma

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Anatomical Context for Phaeochromocytoma

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MalaCards organs/tissues related to Phaeochromocytoma:

32
Adrenal gland, Testes, Thyroid, Heart, Pituitary, Cortex, Retina, Spinal cord, Adipocyte, Breast, Skin, Dorsal root ganglion, Adrenal cortex

Animal Models for Phaeochromocytoma or affiliated genes

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Publications for Phaeochromocytoma

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Articles related to Phaeochromocytoma:

(show top 50)    (show all 549)
idTitleAuthorsYear
1
Diagnosis of extra-adrenal phaeochromocytoma after nephrectomy. (25140231)
2014
2
Anaesthetic management of a dopamine-secreting phaeochromocytoma in multiple endocrine neoplasia 2B syndrome. (24963196)
2014
3
Plasma-free vs deconjugated metanephrines for diagnosis of phaeochromocytoma. (23461656)
2013
4
Don't forget phaeochromocytoma in the differential diagnosis of thunderclap headache. (23390238)
2013
5
Biochemical diagnosis of phaeochromocytoma and paraganglioma. (24347425)
2013
6
Phaeochromocytoma masquerading as anxiety and depression. (23826457)
2013
7
Bilateral Laparoscopic adrenalectomy due to a phaeochromocytoma in Von Hippel-Lindau Syndrome: a technique with 4 trocars. (22591617)
2012
8
Adrenal haemangioblastoma presenting as phaeochromocytoma: a rare manifestation of extraneural hemangioblastoma. (22544391)
2012
9
Phaeochromocytoma -- a classic (but easily forgotten) cause of anxiety. (21687915)
2011
10
Vasopressin for the treatment of catecholamine-resistant hypotension during a phaeochromocytoma resection in a 6-year-old child. (20498605)
2010
11
Plasma metadrenalines in canine phaeochromocytoma. (20418521)
2010
12
Outcomes of minimally invasive surgery for phaeochromocytoma. (19566519)
2009
13
Charles Sugrue, M.D., of Cork (1775-1816) and the first description of a classical medical condition: phaeochromocytoma. (18415053)
2008
14
131I-MIBG therapy in metastatic phaeochromocytoma and paraganglioma. (18071700)
2008
15
Cyclooxygenase-2 expression correlates with phaeochromocytoma malignancy: evidence for a Bcl-2-dependent mechanism. (17916073)
2007
16
Combined coronary artery bypass grafting and phaeochromocytoma excision. (17567351)
2007
17
Magnesium sulphate for phaeochromocytoma crisis. (17919224)
2007
18
Laparoscopic adrenalectomy --- is it any different in phaeochromocytoma and non-phaeochromocytoma? (17962126)
2007
19
MIBG-SPECT/CT-angiography with 3-D reconstruction of an extra-adrenal phaeochromocytoma with dissection of an aortic aneurysm. (17033846)
2007
20
Adrenal cystic phaeochromocytoma: a case report. (16915783)
2006
21
Hypertensive primary intraventricular hemorrhage due to a phaeochromocytoma. (16813639)
2006
22
Phaeochromocytoma, new genes and screening strategies. (17121518)
2006
23
Retrospective analysis of abnormal 24-h urinary free catecholamine concentration in screening for phaeochromocytoma. (12803844)
2003
24
Ruptured phaeochromocytoma--a lesson in acute abdomen. (12777662)
2003
25
An undiagnosed phaeochromocytoma of the urinary bladder. (12413271)
2002
26
Tumour angiogenesis and Ki-67 expression in phaeochromocytoma. (11251535)
2001
27
Treatment of metastatic carcinoid tumours, phaeochromocytoma, paraganglioma and medullary carcinoma of the thyroid with (131)I-meta-iodobenzylguanidine [(131)I-mIBG]. (11453952)
2001
28
Phaeochromocytoma diagnosed during labour. (11573679)
2001
29
Asymptomatic bladder phaeochromocytoma in a 7-year-old boy. (11903845)
2001
30
Metastatic phaeochromocytoma: risks of diagnostic needle puncture and treatment by arterial embolisation. (11317207)
2001
31
Anaesthetic management for caesarean section combined with removal of phaeochromocytoma. (9649999)
1998
32
Cyclic AMP agonists increase levels of insulin-like growth factor (IGF) binding protein-6 in PC12 rat phaeochromocytoma cells. (10984315)
1998
33
Phaeochromocytoma and hypotension. (9612468)
1998
34
Immediate early gene induction by natriuretic peptides in PC12 phaeochromocytoma and C6 glioma cells. (9080415)
1997
35
Hereditary caprine phaeochromocytoma. (9274150)
1997
36
Phaeochromocytoma in Northern Ireland: a 21 year review. (8908450)
1996
37
Giant phaeochromocytoma: case report. (8867505)
1996
38
A minimal CGRP gene promoter is inducible by nerve growth factor in adult rat dorsal root ganglion neurons but not in PC12 phaeochromocytoma cells. (7773437)
1995
39
Postural palpitations--a curious presentation of intrathoracic phaeochromocytoma. (7502292)
1995
40
Investigation of phaeochromocytoma. (8736265)
1995
41
Pitfalls in scanning for phaeochromocytoma. (7914586)
1994
42
High levels of expression of neuropeptide Y mRNA in human phaeochromocytomas. (7955545)
1994
43
Phaeochromocytoma and familial tumour syndromes. (7913426)
1994
44
Phaeochromocytoma in a long-term haemodialysis patient; diagnosis and management. (8272234)
1993
45
Block of the L-type Ca2+ channel pore by external and internal Mg2+ in rat phaeochromocytoma cells. (8410712)
1993
46
Phaeochromocytoma crisis in Sipple's syndrome with intrauterine death and disseminated intravascular coagulation. (15636849)
1993
47
Phaeochromocytoma in multiple endocrine neoplasia type 2 A: survey of 100 cases. (8101147)
1993
48
Identification of a MAP kinase kinase kinase in phaeochromocytoma (PC12) cells. (1468586)
1992
49
Immunocytochemical demonstration of IGF-II immunoreactivity in human phaeochromocytoma and extra-adrenal abdominal paraganglioma. (1635001)
1992
50
The incidence rate of phaeochromocytoma and Conn's syndrome in Denmark, 1977-1981. (3236322)
1988

Variations for Phaeochromocytoma

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Expression for genes affiliated with Phaeochromocytoma

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Expression patterns in normal tissues for genes affiliated with Phaeochromocytoma

Search GEO for disease gene expression data for Phaeochromocytoma.

Pathways for genes affiliated with Phaeochromocytoma

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Pathways related to Phaeochromocytoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
TCA cycle37
pyruvate decarboxylation to acetyl CoA37
NAD phosphorylation and dephosphorylation37
TCA Cycle37
conversion of glucose to acetyl CoA and entry into the TCA cycle37
9.0SDHC, SDHD, SDHB
2
Show member pathways
L-serine degradation37
pentose phosphate pathway (oxidative branch)37
formaldehyde oxidation II (glutathione-dependent)37
9.0SDHC, SDHD, SDHB
3
Show member pathways
8.5SDHB, SDHD, SDHC, MT-CO2
4
Show member pathways
Alzheimers Disease37
8.5MT-CO2, SDHC, SDHD, SDHB
5
Show member pathways
8.2SDHB, SDHD, SDHC, MT-CO2, PNMT

Compounds for genes affiliated with Phaeochromocytoma

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 50PharmGKB
See all sources

Compounds related to Phaeochromocytoma according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1mibg4410.0SDHD, SDHB
2catecholamine449.7SDHD, SDHB, PNMT
3alpha-ketoglutarate449.6SDHB, EGLN2
4Fumaric acid249.3SDHC, SDHD, SDHB
5fumarate44 1110.3SDHC, SDHD, SDHB
6succinic acid28 24 1111.3SDHB, SDHD, SDHC
7iron-sulfur449.3SDHB, SDHD, SDHC
8ubiquinone449.3SDHB, SDHD, SDHC
9Sulfide249.3SDHC, SDHD, SDHB
10QH2249.3SDHB, SDHD, SDHC
11Ubiquinone Q2249.3SDHC, SDHD, SDHB
12Ubiquinone Q1249.3SDHC, SDHD, SDHB
13succinate449.3SDHC, SDHD, SDHB
14FAD249.2SDHB, SDHD, SDHC
15histamine44 28 2411.2PNMT, SCG2, NPPC
16acetylcholine44 50 28 24 1113.1NPPC, SCG2, PNMT
17norepinephrine44 24 1111.0PNMT, SDHB, SCG2, NPPC
18dopamine44 28 24 1111.9SCG2, SDHB, PNMT
19iron44 249.8SDHB, SDHD, SDHC, EGLN2
20superoxide44 249.8SCG2, SDHC, SDHB
21atp44 289.7NPPC, MT-CO2, SCG2, SDHB
22vegf448.5EGLN2, SCG2, SDHC, SDHB
23oxygen44 249.4SDHB, SDHD, SDHC, MT-CO2, EGLN2

GO Terms for genes affiliated with Phaeochromocytoma

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Cellular components related to Phaeochromocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.4NPPC, SCG2
2mitochondrial respiratory chain complex IIGO:0057499.0SDHC, SDHD, SDHB
3mitochondrial inner membraneGO:0057438.9SDHC, SDHD, SDHB
4mitochondrionGO:0057398.1SDHB, SDHD, SDHAF2, SDHC

Biological processes related to Phaeochromocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tricarboxylic acid cycleGO:0060999.1SDHC, SDHD, SDHB
2aerobic respirationGO:0090609.0SDHC, SDHB
3respiratory electron transport chainGO:0229049.0SDHC, SDHD, SDHB
4cellular metabolic processGO:0442378.9SDHB, SDHD, SDHC
5small molecule metabolic processGO:0442818.6SDHC, SDHD, SDHB, PNMT

Molecular functions related to Phaeochromocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ubiquinone bindingGO:0480399.5SDHD, SDHB
2succinate dehydrogenase activityGO:0001049.2SDHC, SDHD
3electron carrier activityGO:0090559.0SDHC, SDHD, SDHB

Products for genes affiliated with Phaeochromocytoma

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  • Antibodies
  • Proteins
  • Lysates

Sources for Phaeochromocytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet