MCID: PHC013
MIFTS: 40

Phaeochromocytoma malady

Summaries for Phaeochromocytoma

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Wikipedia:65 A pheochromocytoma (from Greek phaios \"dark\", chroma \"color\", kytos \"cell\", -oma \"tumor\") or... more...

MalaCards based summary: Phaeochromocytoma is related to paraganglioma and multiple endocrine neoplasia. An important gene associated with Phaeochromocytoma is SDHD (succinate dehydrogenase complex, subunit D, integral membrane protein), and among its related pathways are Citric acid cycle (TCA cycle) and Carbon metabolism. The compounds mibg and catecholamine have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, testes and thyroid.

Aliases & Classifications for Phaeochromocytoma

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Phaeochromocytoma, Aliases & Descriptions:

Name: Phaeochromocytoma 10 12


External Ids:

Disease Ontology10 DOID:0050771

Related Diseases for Phaeochromocytoma

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Diseases related to Phaeochromocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1paraganglioma31.0SCG2, SDHC, SDHAF2, SDHD, SDHB, PNMT
2multiple endocrine neoplasia30.6SDHC, SDHD, SDHB, PNMT
3neurofibromatosis30.5SDHD, SDHB, SDHC
4von hippel-lindau syndrome30.4PNMT, SDHB, SDHD, SDHC
5pheochromocytoma29.9SDHD, SDHB
6neuroblastoma10.4
7thyroiditis10.3
8cushing's syndrome10.3
9ganglioneuroma10.3
10neurofibromatosis, type 110.2
11myocardial infarction10.2
12renal cell carcinoma10.2
13malignant hypertension10.2
14headache10.2
15acute myocardial infarction10.1
16acromegaly10.1
17neuronitis10.1
18cerebritis10.1
19ganglioneuroblastoma10.1
20thunderclap headache10.1
21aneurysm10.1
22hypoxia10.1
23glomus tumor10.0SDHD, SDHB
24familial colorectal cancer10.0SDHB, SDHD
25neurofibromatosis, type 210.0SDHB, SDHD
26carcinoid syndrome10.0PNMT, SDHD, SCG2
27nasopharyngeal carcinoma10.0SDHD, SDHC
28neuroendocrine tumor10.0SCG2, SDHD
29paraganglioma and gastric stromal sarcoma10.0SDHC, SDHB, SDHD
30paragangliomas 1, with or without deafness10.0SDHD, SDHB, SDHC
31gastrointestinal stromal tumor10.0SDHC, SDHB
32carney triad10.0SDHB, SDHD, SDHC
33multiple endocrine neoplasia iia10.0SDHC, SDHD, SDHB
34chondroma10.0SDHB, SDHD, SDHC
35multiple endocrine neoplasia 110.0SDHC, SDHD, SDHB
36adrenal cortical adenoma10.0SDHB, SDHC, SDHD
37hyperparathyroidism10.0SDHC, SDHB, SDHD
38hereditary paraganglioma-pheochromocytoma syndromes10.0SDHD, SDHAF2, SDHB, SDHC
39kidney cancer10.0SDHB, SDHC, NPPC
40hemangioma10.0SDHAF2, SDHD, SDHC, SDHB
41hepatocellular carcinoma9.9
42chondrosarcoma9.9
43obesity9.9
44adult respiratory distress syndrome9.9
45dilated cardiomyopathy9.9
46insulinoma9.9
47myasthenia gravis9.9
48somatostatinoma9.9
49pancreatic mucinous cystadenoma9.9
50cystadenoma9.9

Graphical network of the top 20 diseases related to Phaeochromocytoma:



Diseases related to phaeochromocytoma

Symptoms for Phaeochromocytoma

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Drugs & Therapeutics for Phaeochromocytoma

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Drug clinical trials:

Search ClinicalTrials for Phaeochromocytoma

Search NIH Clinical Center for Phaeochromocytoma

Genetic Tests for Phaeochromocytoma

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Anatomical Context for Phaeochromocytoma

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MalaCards organs/tissues related to Phaeochromocytoma:

33
Adrenal gland, Testes, Thyroid, Heart, Pituitary, Cortex, Retina, Spinal cord, Adipocyte, Breast, Skin, Dorsal root ganglion, Adrenal cortex

Animal Models for Phaeochromocytoma or affiliated genes

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Publications for Phaeochromocytoma

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Articles related to Phaeochromocytoma:

(show top 50)    (show all 556)
idTitleAuthorsYear
1
Diagnosing phaeochromocytoma/paraganglioma in a patient presenting with critical illness: biochemistry versus imaging. (25683095)
2015
2
Diagnosis of extra-adrenal phaeochromocytoma after nephrectomy. (25140231)
2014
3
Anaesthetic management of a dopamine-secreting phaeochromocytoma in multiple endocrine neoplasia 2B syndrome. (24963196)
2014
4
Plasma-free vs deconjugated metanephrines for diagnosis of phaeochromocytoma. (23461656)
2013
5
Don't forget phaeochromocytoma in the differential diagnosis of thunderclap headache. (23390238)
2013
6
Biochemical diagnosis of phaeochromocytoma and paraganglioma. (24347425)
2013
7
Phaeochromocytoma masquerading as anxiety and depression. (23826457)
2013
8
Bilateral Laparoscopic adrenalectomy due to a phaeochromocytoma in Von Hippel-Lindau Syndrome: a technique with 4 trocars. (22591617)
2012
9
Adrenal haemangioblastoma presenting as phaeochromocytoma: a rare manifestation of extraneural hemangioblastoma. (22544391)
2012
10
Phaeochromocytoma -- a classic (but easily forgotten) cause of anxiety. (21687915)
2011
11
Vasopressin for the treatment of catecholamine-resistant hypotension during a phaeochromocytoma resection in a 6-year-old child. (20498605)
2010
12
Plasma metadrenalines in canine phaeochromocytoma. (20418521)
2010
13
Outcomes of minimally invasive surgery for phaeochromocytoma. (19566519)
2009
14
Charles Sugrue, M.D., of Cork (1775-1816) and the first description of a classical medical condition: phaeochromocytoma. (18415053)
2008
15
131I-MIBG therapy in metastatic phaeochromocytoma and paraganglioma. (18071700)
2008
16
Cyclooxygenase-2 expression correlates with phaeochromocytoma malignancy: evidence for a Bcl-2-dependent mechanism. (17916073)
2007
17
Combined coronary artery bypass grafting and phaeochromocytoma excision. (17567351)
2007
18
Magnesium sulphate for phaeochromocytoma crisis. (17919224)
2007
19
Laparoscopic adrenalectomy --- is it any different in phaeochromocytoma and non-phaeochromocytoma? (17962126)
2007
20
MIBG-SPECT/CT-angiography with 3-D reconstruction of an extra-adrenal phaeochromocytoma with dissection of an aortic aneurysm. (17033846)
2007
21
Adrenal cystic phaeochromocytoma: a case report. (16915783)
2006
22
Hypertensive primary intraventricular hemorrhage due to a phaeochromocytoma. (16813639)
2006
23
Phaeochromocytoma, new genes and screening strategies. (17121518)
2006
24
Retrospective analysis of abnormal 24-h urinary free catecholamine concentration in screening for phaeochromocytoma. (12803844)
2003
25
Ruptured phaeochromocytoma--a lesson in acute abdomen. (12777662)
2003
26
An undiagnosed phaeochromocytoma of the urinary bladder. (12413271)
2002
27
Tumour angiogenesis and Ki-67 expression in phaeochromocytoma. (11251535)
2001
28
Treatment of metastatic carcinoid tumours, phaeochromocytoma, paraganglioma and medullary carcinoma of the thyroid with (131)I-meta-iodobenzylguanidine [(131)I-mIBG]. (11453952)
2001
29
Phaeochromocytoma diagnosed during labour. (11573679)
2001
30
Asymptomatic bladder phaeochromocytoma in a 7-year-old boy. (11903845)
2001
31
Anaesthetic management for caesarean section combined with removal of phaeochromocytoma. (9649999)
1998
32
Cyclic AMP agonists increase levels of insulin-like growth factor (IGF) binding protein-6 in PC12 rat phaeochromocytoma cells. (10984315)
1998
33
Phaeochromocytoma and hypotension. (9612468)
1998
34
Immediate early gene induction by natriuretic peptides in PC12 phaeochromocytoma and C6 glioma cells. (9080415)
1997
35
Hereditary caprine phaeochromocytoma. (9274150)
1997
36
Phaeochromocytoma in Northern Ireland: a 21 year review. (8908450)
1996
37
Giant phaeochromocytoma: case report. (8867505)
1996
38
A minimal CGRP gene promoter is inducible by nerve growth factor in adult rat dorsal root ganglion neurons but not in PC12 phaeochromocytoma cells. (7773437)
1995
39
Postural palpitations--a curious presentation of intrathoracic phaeochromocytoma. (7502292)
1995
40
Investigation of phaeochromocytoma. (8736265)
1995
41
Pitfalls in scanning for phaeochromocytoma. (7914586)
1994
42
High levels of expression of neuropeptide Y mRNA in human phaeochromocytomas. (7955545)
1994
43
Phaeochromocytoma and familial tumour syndromes. (7913426)
1994
44
Phaeochromocytoma in a long-term haemodialysis patient; diagnosis and management. (8272234)
1993
45
Block of the L-type Ca2+ channel pore by external and internal Mg2+ in rat phaeochromocytoma cells. (8410712)
1993
46
Phaeochromocytoma crisis in Sipple's syndrome with intrauterine death and disseminated intravascular coagulation. (15636849)
1993
47
Phaeochromocytoma in multiple endocrine neoplasia type 2 A: survey of 100 cases. (8101147)
1993
48
Identification of a MAP kinase kinase kinase in phaeochromocytoma (PC12) cells. (1468586)
1992
49
Immunocytochemical demonstration of IGF-II immunoreactivity in human phaeochromocytoma and extra-adrenal abdominal paraganglioma. (1635001)
1992
50
The incidence rate of phaeochromocytoma and Conn's syndrome in Denmark, 1977-1981. (3236322)
1988

Variations for Phaeochromocytoma

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Expression for genes affiliated with Phaeochromocytoma

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Search GEO for disease gene expression data for Phaeochromocytoma.

Pathways for genes affiliated with Phaeochromocytoma

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Pathways related to Phaeochromocytoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
TCA cycle38
pyruvate decarboxylation to acetyl CoA38
NAD phosphorylation and dephosphorylation38
TCA Cycle38
conversion of glucose to acetyl CoA and entry into the TCA cycle38
9.0SDHC, SDHD, SDHB
2
Show member pathways
L-serine degradation38
pentose phosphate pathway (oxidative branch)38
formaldehyde oxidation II (glutathione-dependent)38
9.0SDHC, SDHD, SDHB
3
Show member pathways
8.5SDHB, SDHD, SDHC, MT-CO2
4
Show member pathways
Alzheimers Disease38
8.5MT-CO2, SDHC, SDHD, SDHB
5
Show member pathways
8.2SDHB, SDHD, SDHC, MT-CO2, PNMT

Compounds for genes affiliated with Phaeochromocytoma

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Sources:
45Novoseek, 26HMDB, 13DrugBank, 30IUPHAR, 51PharmGKB
See all sources

Compounds related to Phaeochromocytoma according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1mibg4510.0SDHD, SDHB
2catecholamine459.7SDHD, SDHB, PNMT
3alpha-ketoglutarate459.6SDHB, EGLN2
4Fumaric acid269.3SDHC, SDHD, SDHB
5fumarate45 1310.3SDHC, SDHD, SDHB
6succinic acid30 26 1311.3SDHB, SDHD, SDHC
7iron-sulfur459.3SDHB, SDHD, SDHC
8ubiquinone459.3SDHB, SDHD, SDHC
9Sulfide269.3SDHC, SDHD, SDHB
10QH2269.3SDHB, SDHD, SDHC
11Ubiquinone Q2269.3SDHC, SDHD, SDHB
12Ubiquinone Q1269.3SDHC, SDHD, SDHB
13succinate459.3SDHC, SDHD, SDHB
14FAD269.2SDHB, SDHD, SDHC
15histamine45 30 2611.2PNMT, SCG2, NPPC
16acetylcholine45 51 30 26 1313.1NPPC, SCG2, PNMT
17norepinephrine45 26 1311.0PNMT, SDHB, SCG2, NPPC
18dopamine45 30 26 1311.9SCG2, SDHB, PNMT
19iron45 269.8SDHB, SDHD, SDHC, EGLN2
20superoxide45 269.8SCG2, SDHC, SDHB
21atp45 309.7NPPC, MT-CO2, SCG2, SDHB
22vegf458.5EGLN2, SCG2, SDHC, SDHB
23oxygen45 269.4SDHB, SDHD, SDHC, MT-CO2, EGLN2

GO Terms for genes affiliated with Phaeochromocytoma

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Cellular components related to Phaeochromocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:00301419.4NPPC, SCG2
2mitochondrial respiratory chain complex IIGO:00057499.0SDHC, SDHD, SDHB
3mitochondrial inner membraneGO:00057438.9SDHC, SDHD, SDHB
4mitochondrionGO:00057398.1SDHB, SDHD, SDHAF2, SDHC

Biological processes related to Phaeochromocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tricarboxylic acid cycleGO:00060999.1SDHC, SDHD, SDHB
2aerobic respirationGO:00090609.0SDHC, SDHB
3respiratory electron transport chainGO:00229049.0SDHC, SDHD, SDHB
4cellular metabolic processGO:00442378.9SDHB, SDHD, SDHC
5small molecule metabolic processGO:00442818.6SDHC, SDHD, SDHB, PNMT

Molecular functions related to Phaeochromocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ubiquinone bindingGO:00480399.5SDHD, SDHB
2succinate dehydrogenase activityGO:00001049.2SDHC, SDHD
3electron carrier activityGO:00090559.0SDHC, SDHD, SDHB

Products for genes affiliated with Phaeochromocytoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Phaeochromocytoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet