MCID: PHR003
MIFTS: 56

Pharyngitis malady

Respiratory diseases, Oral diseases categories

Aliases & Classifications for Pharyngitis

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 38NCIt, 27ICD9CM, 25ICD10
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Pharyngitis, Aliases & Descriptions:

Name: Pharyngitis 9 11 43 60
Chronic Pharyngitis 9 60
Acute Pharyngitis 9 60
Chronic Pharyngitis and Nasopharyngitis 9
Chronic Pharyn/nasopharyngitis 9
Persistent Sore Throat 9
Sore Throat - Chronic 9
 
Acute Sore Throat Nos 9
Pharyngeal Disorder 9
Pharyngitis - Acute 9
Chronic Sore Throat 9
Pharyngeal Diseases 60
Acute Sore Throat 9
Inflamed Throat 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases, Oral diseases


Summaries for Pharyngitis

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Disease Ontology:9 An upper respiratory tract disease involving inflammation of the throat or pharynx resulting from bacterial, viral, fungal infections or irritants like pollutants or chemical substances and smoking. the infection is often referred to as "sore throat". the symptoms include pain during swallowing, enlarged tonsils coated with a white discharge, runny nose, cough and slight fever.

MalaCards based summary: Pharyngitis, also known as chronic pharyngitis, is related to cervical adenitis and tonsillitis. An important gene associated with Pharyngitis is ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide), and among its related pathways are LDL Oxidation in Atherogenesis and Monoamine Transport. The drugs guaifenesin and cefditoren and the compounds tocilizumab and cdp571 have been mentioned in the context of this disorder. Affiliated tissues include tonsil, testes and heart, and related mouse phenotypes are skeleton and immune system.

Wikipedia:63 Pharyngitis /f more...

Related Diseases for Pharyngitis

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Diseases related to Pharyngitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 323)
idRelated DiseaseScoreTop Affiliating Genes
1cervical adenitis31.6HSF4
2tonsillitis31.0KSR1, CRP, LACTB, HSF4
3adult-onset still's disease30.6CRP
4parotitis30.5HSF4
5otitis media30.5IL1B, LACTB
6erysipelas30.5MEFV
7bacteremia30.4CRP, LACTB
8arthritis30.4IL1B, TNF
9mediastinitis30.3CRP
10septic arthritis30.3CRP
11bronchitis30.3CRP, HSF4
12respiratory failure30.1CRP, TNF, IL1B
13osteomyelitis30.1CRP, LACTB
14toxic shock syndrome30.0SPEG, TNF, IL1B, LACTB
15pneumonia30.0LACTB, TNF, IL1B, CRP, HSF4
16meningitis30.0IL1B, LACTB, CRP
17malaria29.8TNF, IL1B
18systemic lupus erythematosus29.7CRP, FCGR1A, TNF, HLA-DRB1
19colitis29.6IL1B, TNF, PTGS2
20asthma29.6TNF, IL1B, CD1A, HLA-DRB1
21leukemia29.2HLA-DRB1, TNF, IL1B, CD1A, LACTB
22tuberculosis29.2IL1B, TNF, CRP, LACTB, HLA-DRB1, CD1A
23rheumatoid arthritis28.6CRP, IL1B, HLA-DRB1, PTGS2, TNF, FCGR1A
24stomatitis10.7
25aphthous stomatitis10.7
26cervicitis10.6
27laryngitis10.6
28periodic fever, aphthous stomatitis, pharyngitis and adenitis10.6
29palindromic rheumatism10.5MEFV
30polyarteritis nodosa10.5MEFV
31endophthalmitis10.5LACTB
32periodic fever, familial10.4TNF, MEFV
33familial mediterranean fever, ar10.4MEFV, TNF
34gonorrhea10.4
35dysphagia10.4
36epidural abscess10.4CRP
37rheumatic fever10.4
38blindness10.3
39sleep apnea10.3
40rheumatic heart disease10.3
41esophagitis10.3
42appendicitis10.3CRP, LACTB
43digeorge syndrome10.3
44pelvic inflammatory disease10.3CRP, LACTB
45spondylarthropathy10.3CRP, TNF
46velocardiofacial syndrome10.2
47intervertebral disc disease10.2IL1B
48pyelonephritis10.2LACTB, CRP
49leprosy10.2HLA-DRB1
50secondary amyloidosis10.2CRP, MEFV

Graphical network of the top 20 diseases related to Pharyngitis:



Diseases related to pharyngitis

Symptoms for Pharyngitis

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Drugs & Therapeutics for Pharyngitis

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Drug clinical trials:

Search ClinicalTrials for Pharyngitis

Search NIH Clinical Center for Pharyngitis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Pharyngitis

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Anatomical Context for Pharyngitis

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MalaCards organs/tissues related to Pharyngitis:

31
Tonsil, Testes, Heart, Bone, Endothelial, Cortex, Colon, Monocytes, Neutrophil, Lymph node, Salivary gland, Lung, Thyroid, Myeloid, T cells, Pituitary

Animal Models for Pharyngitis or affiliated genes

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MGI Mouse Phenotypes related to Pharyngitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.1IL1B, MEFV, FCGR1A, PTGS2, TNF, KSR1
2MP:00053877.3CRP, KSR1, TNF, PTGS2, FCGR1A, ADH5

Publications for Pharyngitis

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Articles related to Pharyngitis:

(show top 50)    (show all 858)
idTitleAuthorsYear
1
Klebsiella pneumoniae in a patient with hoarseness and dysphagia rather than pharyngitis. (25623636)
2015
2
Expect the Unexpected: Report of a Case of Pediatric Pharyngeal Extraosseous Plasmacytoma with Tumefactive Amyloidosis ("Amyloidoma") and a Review of the Literature. (25672253)
2015
3
Variability in the diagnosis and treatment of group a streptococcal pharyngitis by primary care pediatricians. (25222902)
2014
4
Parathyroid adenoma in third pharyngeal pouch cyst as a rare case of primary hyperparathyroidism. (25245714)
2014
5
Measures of user experience in a streptococcal pharyngitis and pneumonia clinical decision support tools. (25298820)
2014
6
Primary care management of group A streptococcal pharyngitis in Northland. (25194245)
2014
7
Tea intake and risk of oral, pharyngeal, and laryngeal carcinoma: a meta-analysis. (25363316)
2014
8
A probable food-borne outbreak of pharyngitis after a massive rainstorm in Beijing, caused by emm89 group A Streptococcus rarely found in China. (23375890)
2013
9
Necrotic pharyngitis associated with Mycoplasma bovis infections in American bison (Bison bison). (23512925)
2013
10
Halzoun, an allergic pharyngitis syndrome in Lebanon: the trematode Dicrocoelium dendriticum as an additional cause. (23022355)
2013
11
About group A streptococcal pharyngitis guidelines. (23550388)
2013
12
Management of adults with acute streptococcal pharyngitis: minimal value for backup strep testing and overuse of antibiotics. (23054930)
2013
13
A retrospective comparative study of 2-drug oral and intramuscular cephalosporin treatment regimens for pharyngeal gonorrhea. (23408680)
2013
14
Elevated levels of CXCL10 in the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis syndrome (PFAPA) during and between febrile episodes; an indication of a persistent activation of the innate immune system. (24134207)
2013
15
Three-dimensional analysis of the pharyngeal airway morphology in growing Japanese girls with and without cleft lip and palate. (22449605)
2012
16
A case of resistant adult-onset periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome responsive to anakinra. (22931584)
2012
17
Dose-response analysis of acute oral mucositis and pharyngeal dysphagia in patients receiving induction chemotherapy followed by concomitant chemo-IMRT for head and neck cancer. (22280809)
2012
18
Percutaneous endoscopic gastrostomy feeding--a life-saving intervention in SSc-myositis overlap with pharyngeal dysfunction. (22461389)
2012
19
The involvement of RCAS1 in creating a suppressive tumor microenvironment in patients with pharyngeal squamous cell carcinoma]. (23164108)
2012
20
Val66Met in brain-derived neurotrophic factor affects stimulus-induced plasticity in the human pharyngeal motor cortex. (21699787)
2011
21
Adolescent pharyngitis: a review of bacterial causes. (21646249)
2011
22
Transtubal photo of the middle ear in a newborn after removal of a pharyngeal teratoma. (21493335)
2011
23
Epidemiological characterization of Streptococcus pyogenes isolated from patients with multiple onsets of pharyngitis. (21362024)
2011
24
Down-regulation of EBV-LMP1 radio-sensitizes nasal pharyngeal carcinoma cells via NF-I_B regulated ATM expression. (22096476)
2011
25
Antimicrobial prescribing in the USA for adult acute pharyngitis in relation to treatment guidelines. (20586844)
2011
26
Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA). (20824883)
2010
27
The evaluation of SD Bioline Strep A rapid antigen test in acute pharyngitis in pediatric clinics. (19726894)
2009
28
Seven-year surveillance of north american pediatric group a streptococcal pharyngitis isolates. (19480575)
2009
29
Two siblings with periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA) syndrome. (19209090)
2009
30
Case of the month. Streptococcal pharyngitis and infectious mononucleosis. (18795552)
2008
31
Psoriasiform eruption and pharyngitis. (18283187)
2008
32
Symptomatic treatment of acute tonsillo-pharyngitis patients with a combination of Nigella sativa and Phyllanthus niruri extract. (18541126)
2008
33
The evidence base for cephalosporin superiority over penicillin in streptococcal pharyngitis. (17292576)
2007
34
Quality of care in the retail health care setting using national clinical guidelines for acute pharyngitis. (18006426)
2007
35
Prevalence and incidence of pharyngeal gonorrhea in a longitudinal sample of men who have sex with men: the EXPLORE study. (17051493)
2006
36
Orbital myositis following streptococcal pharyngitis in a pediatric patient. (15832845)
2005
37
Acute pharyngitis: an unusual presentation of acute endemic typhus. (16213963)
2005
38
Pharyngitis clinical prediction rules: effect of interobserver agreement: a MetroNet study. (15125623)
2004
39
Proton pump inhibitor therapy for chronic laryngo-pharyngitis: a randomized placebo-control trial. (15467597)
2004
40
Extracellular matrix-regulated p53 expression and nuclear localization in cultured Detroit 562 cells derived from pharyngeal carcinoma. (15018144)
2003
41
Respiratory failure due to pharyngeal dysfunction: a singular presentation of brainstem listeriosis. (12528037)
2003
42
Validation and modification of streptococcal pharyngitis clinical prediction rules. (12630581)
2003
43
Efficacy of single-dose dexamethasone as adjuvant therapy for acute pharyngitis. (11802044)
2002
44
Diagnosis and treatment of pharyngitis in adults. (17637161)
2002
45
Macrolide therapy of group A streptococcal pharyngitis: 10 days of macrolide therapy (clarithromycin) is more effective in streptococcal eradication than 5 days (azithromycin). (11360224)
2001
46
Bacteriological and clinical efficacy of various antibiotics used in the treatment of streptococcal pharyngitis in Italy. An epidemiological study. (11463521)
2001
47
Pharyngeal carriage of group C and group G streptococci and acute rheumatic fever in an Aboriginal population. (11030302)
2000
48
Periodic fever, aphthous stomatitis, pharyngitis, and adenopathy syndrome: clinical characteristics and outcome. (10393612)
1999
49
Improving diagnostic accuracy of bacterial pharyngitis by near patient measurement of C-reactive protein (CRP) (10326264)
1999
50
Oral and pharyngeal adenosquamous carcinoma. A report of four cases with immunohistochemical studies. (1716111)
1991

Variations for Pharyngitis

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Expression for genes affiliated with Pharyngitis

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Search GEO for disease gene expression data for Pharyngitis.

Pathways for genes affiliated with Pharyngitis

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Pathways related to Pharyngitis according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IL1B, TNF
2
Show member pathways
Serotonin Transporter Activity36
9.9IL1B, TNF
39.9IL1B, TNF
49.9IL1B, TNF
59.8TNF, PTGS2
69.6TNF, FCGR1A, IL1B
7
Show member pathways
9.6TNF, MEFV, IL1B
89.6IL1B, TNF, HLA-DRB1
99.6HLA-DRB1, TNF, IL1B
10
Show member pathways
Immune response MIF in innate immunity response58
9.5TNF, PTGS2, IL1B
119.5TNF, PTGS2, IL1B
129.5IL1B, PTGS2, TNF
139.5IL1B, PTGS2, TNF
14
Show member pathways
thioredoxin pathway36
9.1TNF, PTGS2, IL1B, CRP
159.1CD1A, IL1B, FCGR1A, TNF, HLA-DRB1
16
Show member pathways
8.9HLA-DRB1, TNF, PTGS2, FCGR1A, IL1B
17
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
8.7KSR1, TNF, PTGS2, IL1B
188.5IL1B, FCGR1A, TNF, KSR1, HLA-DRB1

Compounds for genes affiliated with Pharyngitis

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Compounds related to Pharyngitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1tocilizumab43 1211.3TNF, CRP
2cdp5714310.3CRP, TNF
3alefacept43 1211.3TNF, FCGR1A
4n,n-dimethylsphingosine43 5911.2IL1B, TNF
5cicaprost43 2811.2TNF, IL1B
6turpentine4310.2IL1B, CRP
7vesnarinone4310.2TNF, IL1B
8lenalidomide43 1211.1TNF, PTGS2
9taurine chloramine4310.1TNF, IL1B
10adalimumab43 49 1212.1CRP, FCGR1A, TNF
11aceclofenac4310.1IL1B, PTGS2
12bucillamine4310.1CRP, IL1B
13hydroxychloroquine43 1211.1CRP, TNF
14efalizumab43 1211.1TNF, FCGR1A
15gabexate mesilate4310.1CRP, TNF
16rituximab43 49 1212.0CRP, FCGR1A, TNF
17gold sodium thiomalate4310.0IL1B, TNF, HLA-DRB1
18tenidap43 2811.0CRP, IL1B, TNF
19anakinra43 1211.0TNF, IL1B, CRP
20sulprostone43 2811.0PTGS2, IL1B
21infliximab43 49 1211.9CRP, IL1B, TNF
22neopterin439.9CRP, IL1B, TNF
23leflunomide43 49 1211.9IL1B, PTGS2, TNF
24triptolide439.9IL1B, PTGS2, TNF
25ciglitazone43 2810.9TNF, PTGS2, IL1B
26ns 39843 5910.9TNF, PTGS2, IL1B
27ndga439.9IL1B, PTGS2, TNF
28pioglitazone28 43 49 1212.9CRP, PTGS2, TNF
2915-deoxy-delta-12,14-prostaglandin j2439.8TNF, PTGS2, IL1B
30pdtc439.8TNF, PTGS2, IL1B
31thalidomide43 49 59 1212.8IL1B, PTGS2, TNF
32toxin-1439.8TNF, IL1B
33prednisolone43 28 1211.8TNF, FCGR1A, CRP
34ivig439.7TNF, FCGR1A, IL1B, CRP
35pgh2439.7IL1B, PTGS2
36endotoxin439.7CRP, IL1B, MEFV, TNF
37ceftriaxone43 1210.7LACTB, CRP
38herbimycin a43 5910.7TNF, PTGS2, FCGR1A, IL1B
39methotrexate49 43 1211.6CRP, IL1B, TNF, HLA-DRB1
40sulfasalazine28 43 49 1212.6TNF, PTGS2, IL1B, CRP
41prostacyclin439.5TNF, PTGS2, IL1B, CRP
42actinomycin d439.5IL1B, FCGR1A, PTGS2, TNF
43n acetylcysteine439.5TNF, PTGS2, IL1B, CRP
44sb 20358043 5910.5TNF, PTGS2, IL1B, CRP
45ly294002439.5TNF, PTGS2, IL1B, CRP
46genistein43 28 59 2 24 1214.5TNF, PTGS2, FCGR1A, IL1B
47arachidonic acid43 28 24 1212.4TNF, PTGS2, FCGR1A, IL1B
48etanercept43 49 1211.3CRP, IL1B, FCGR1A, PTGS2, TNF
49cycloheximide439.3TNF, PTGS2, FCGR1A, IL1B, CRP
50troglitazone43 28 59 1212.2IL1B, PTGS2, TNF

GO Terms for genes affiliated with Pharyngitis

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Cellular components related to Pharyngitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1clathrin-coated endocytic vesicle membraneGO:00306699.9FCGR1A, HLA-DRB1

Biological processes related to Pharyngitis according to GeneCards Suite gene sharing:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1sequestering of triglycerideGO:003073010.2IL1B, TNF
2negative regulation of lipid storageGO:001088810.2CRP, TNF
3positive regulation of calcidiol 1-monooxygenase activityGO:006055910.2IL1B, TNF
4positive regulation of heterotypic cell-cell adhesionGO:003411610.2TNF, IL1B
5positive regulation of chemokine biosynthetic processGO:004508010.1IL1B, TNF
6regulation of I-kappaB kinase/NF-kappaB signalingGO:004312210.1TNF, IL1B
7positive regulation of membrane protein ectodomain proteolysisGO:005104410.0IL1B, TNF
8negative regulation of lipid catabolic processGO:005099510.0TNF, IL1B
9lipopolysaccharide-mediated signaling pathwayGO:00316639.9IL1B, TNF
10negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:020012409.9IL1B, TNF
11positive regulation of fever generationGO:00316229.8IL1B, PTGS2, TNF
12positive regulation of NF-kappaB import into nucleusGO:00423469.8IL1B, PTGS2, TNF
13positive regulation of mitosisGO:00458409.8TNF, IL1B
14positive regulation of nitric oxide biosynthetic processGO:00454299.8TNF, PTGS2, IL1B
15positive regulation vascular endothelial growth factor productionGO:00105759.8IL1B, PTGS2
16protein kinase B signalingGO:00434919.6IL1B, TNF
17immune responseGO:00069559.5CD1A, IL1B, FCGR1A, HLA-DRB1
18negative regulation of cell proliferationGO:00082859.3SPEG, TNF, PTGS2, IL1B
19inflammatory responseGO:00069549.2TNF, PTGS2, MEFV, IL1B, CRP

Products for genes affiliated with Pharyngitis

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Sources for Pharyngitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet