MCID: PHR003
MIFTS: 66

Pharyngitis malady

Respiratory diseases, Oral diseases categories
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Summaries for Pharyngitis

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Disease Ontology:8 An upper respiratory tract disease involving inflammation of the throat or pharynx resulting from bacterial, viral, fungal infections or irritants like pollutants or chemical substances and smoking. the infection is often referred to as "sore throat". the symptoms include pain during swallowing, enlarged tonsils coated with a white discharge, runny nose, cough and slight fever.

MalaCards based summary: Pharyngitis, also known as persistent sore throat, is related to cervical adenitis and tonsillitis. An important gene associated with Pharyngitis is ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide), and among its related pathways are LDL Oxidation in Atherogenesis and Monoamine Transport. The drugs guaifenesin and cefditoren and the compounds tocilizumab and cdp571 have been mentioned in the context of this disorder. Affiliated tissues include tonsil, testes and heart, and related mouse phenotypes are skeleton and immune system.

Wikipedia:65 Pharyngitis /f more...

Aliases & Classifications for Pharyngitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 39NCIt, 27ICD9CM, 25ICD10
See all sources

Pharyngitis, Aliases & Descriptions:

Name: Pharyngitis 8 10 44 62
Persistent Sore Throat 8 62
Chronic Pharyngitis 8 62
Acute Pharyngitis 8 62
Inflamed Throat 8 62
Chronic Pharyngitis and Nasopharyngitis 8
Chronic Pharyn/nasopharyngitis 8
 
Acute Sore Throat Nos 8
Sore Throat - Chronic 8
Pharyngitis - Acute 8
Pharyngeal Diseases 62
Pharyngeal Disorder 8
Chronic Sore Throat 8
Acute Sore Throat 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases, Oral diseases


Related Diseases for Pharyngitis

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Diseases related to Pharyngitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 321)
idRelated DiseaseScoreTop Affiliating Genes
1cervical adenitis31.6HSF4
2tonsillitis31.0KSR1, HSF4, LACTB, CRP
3adult-onset still's disease30.5CRP
4parotitis30.5HSF4
5otitis media30.5IL1B, LACTB
6erysipelas30.5MEFV
7bacteremia30.5LACTB, CRP
8arthritis30.4TNF, IL1B
9familial mediterranean fever30.4TNF, MEFV
10mediastinitis30.3CRP
11septic arthritis30.3CRP
12bronchitis30.3CRP, HSF4
13respiratory failure30.1CRP, IL1B, TNF
14osteomyelitis30.1CRP, LACTB
15toxic shock syndrome30.1IL1B, LACTB, TNF, SPEG
16pneumonia30.0TNF, HSF4, LACTB, IL1B, CRP
17meningitis30.0LACTB, IL1B, CRP
18sepsis29.7CRP, IL1B, LACTB, FCGR1A, TNF
19systemic lupus erythematosus29.7HLA-DRB1, TNF, FCGR1A, CRP
20colitis29.7TNF, PTGS2, IL1B
21asthma29.6CD1A, IL1B, TNF, HLA-DRB1
22tuberculosis29.2HLA-DRB1, TNF, LACTB, IL1B, CRP, CD1A
23leukemia29.2HLA-DRB1, TNF, LACTB, IL1B, CD1A
24rheumatoid arthritis28.6HLA-DRB1, TNF, PTGS2, FCGR1A, MEFV, IL1B
25stomatitis10.7
26aphthous stomatitis10.7
27cervicitis10.6
28laryngitis10.6
29palindromic rheumatism10.5MEFV
30polyarteritis nodosa10.5MEFV
31periodic fever, aphthous stomatitis, pharyngitis and adenitis10.5
32endophthalmitis10.5LACTB
33periodic fever, familial, autosomal dominant10.4TNF, MEFV
34gonorrhea10.4
35epidural abscess10.4CRP
36dysphagia10.4
37malaria10.4TNF, HLA-DRB1
38rheumatic fever10.3
39blindness10.3
40digeorge syndrome10.3
41sleep apnea10.3
42esophagitis10.3
43appendicitis10.3LACTB, CRP
44pelvic inflammatory disease10.3LACTB, CRP
45spondylarthropathy10.3TNF, CRP
46pyelonephritis10.2LACTB, CRP
47degenerative disc disease10.2IL1B
48leprosy10.2HLA-DRB1
49amyloidosis, secondary10.2CRP, MEFV
50obstructive sleep apnea10.2

Graphical network of the top 20 diseases related to Pharyngitis:



Diseases related to pharyngitis

Symptoms for Pharyngitis

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Drugs & Therapeutics for Pharyngitis

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Drug clinical trials:

Search ClinicalTrials for Pharyngitis

Search NIH Clinical Center for Pharyngitis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Pharyngitis

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Anatomical Context for Pharyngitis

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MalaCards organs/tissues related to Pharyngitis:

32
Tonsil, Testes, Heart, Bone, Cortex, Colon, Monocytes, Endothelial, Neutrophil, Salivary gland, Lymph node, Lung, Thyroid, Myeloid, Pituitary

Animal Models for Pharyngitis or affiliated genes

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MGI Mouse Phenotypes related to Pharyngitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.1IL1B, MEFV, FCGR1A, PTGS2, TNF, KSR1
2MP:00053877.3CRP, KSR1, TNF, PTGS2, FCGR1A, ADH5

Publications for Pharyngitis

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Articles related to Pharyngitis:

(show top 50)    (show all 838)
idTitleAuthorsYear
1
Variability in the diagnosis and treatment of group a streptococcal pharyngitis by primary care pediatricians. (25222902)
2014
2
Parathyroid adenoma in third pharyngeal pouch cyst as a rare case of primary hyperparathyroidism. (25245714)
2014
3
Measures of user experience in a streptococcal pharyngitis and pneumonia clinical decision support tools. (25298820)
2014
4
Primary care management of group A streptococcal pharyngitis in Northland. (25194245)
2014
5
Tea intake and risk of oral, pharyngeal, and laryngeal carcinoma: a meta-analysis. (25363316)
2014
6
A probable food-borne outbreak of pharyngitis after a massive rainstorm in Beijing, caused by emm89 group A Streptococcus rarely found in China. (23375890)
2013
7
Necrotic pharyngitis associated with Mycoplasma bovis infections in American bison (Bison bison). (23512925)
2013
8
Halzoun, an allergic pharyngitis syndrome in Lebanon: the trematode Dicrocoelium dendriticum as an additional cause. (23022355)
2013
9
About group A streptococcal pharyngitis guidelines. (23550388)
2013
10
Management of adults with acute streptococcal pharyngitis: minimal value for backup strep testing and overuse of antibiotics. (23054930)
2013
11
A retrospective comparative study of 2-drug oral and intramuscular cephalosporin treatment regimens for pharyngeal gonorrhea. (23408680)
2013
12
Elevated levels of CXCL10 in the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis syndrome (PFAPA) during and between febrile episodes; an indication of a persistent activation of the innate immune system. (24134207)
2013
13
Three-dimensional analysis of the pharyngeal airway morphology in growing Japanese girls with and without cleft lip and palate. (22449605)
2012
14
A case of resistant adult-onset periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome responsive to anakinra. (22931584)
2012
15
Dose-response analysis of acute oral mucositis and pharyngeal dysphagia in patients receiving induction chemotherapy followed by concomitant chemo-IMRT for head and neck cancer. (22280809)
2012
16
Percutaneous endoscopic gastrostomy feeding--a life-saving intervention in SSc-myositis overlap with pharyngeal dysfunction. (22461389)
2012
17
The involvement of RCAS1 in creating a suppressive tumor microenvironment in patients with pharyngeal squamous cell carcinoma]. (23164108)
2012
18
Val66Met in brain-derived neurotrophic factor affects stimulus-induced plasticity in the human pharyngeal motor cortex. (21699787)
2011
19
Adolescent pharyngitis: a review of bacterial causes. (21646249)
2011
20
Transtubal photo of the middle ear in a newborn after removal of a pharyngeal teratoma. (21493335)
2011
21
Epidemiological characterization of Streptococcus pyogenes isolated from patients with multiple onsets of pharyngitis. (21362024)
2011
22
Down-regulation of EBV-LMP1 radio-sensitizes nasal pharyngeal carcinoma cells via NF-I_B regulated ATM expression. (22096476)
2011
23
Antimicrobial prescribing in the USA for adult acute pharyngitis in relation to treatment guidelines. (20586844)
2011
24
Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA). (20824883)
2010
25
The evaluation of SD Bioline Strep A rapid antigen test in acute pharyngitis in pediatric clinics. (19726894)
2009
26
Seven-year surveillance of north american pediatric group a streptococcal pharyngitis isolates. (19480575)
2009
27
Two siblings with periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA) syndrome. (19209090)
2009
28
Case of the month. Streptococcal pharyngitis and infectious mononucleosis. (18795552)
2008
29
Psoriasiform eruption and pharyngitis. (18283187)
2008
30
Symptomatic treatment of acute tonsillo-pharyngitis patients with a combination of Nigella sativa and Phyllanthus niruri extract. (18541126)
2008
31
The evidence base for cephalosporin superiority over penicillin in streptococcal pharyngitis. (17292576)
2007
32
Quality of care in the retail health care setting using national clinical guidelines for acute pharyngitis. (18006426)
2007
33
Prevalence and incidence of pharyngeal gonorrhea in a longitudinal sample of men who have sex with men: the EXPLORE study. (17051493)
2006
34
Orbital myositis following streptococcal pharyngitis in a pediatric patient. (15832845)
2005
35
Acute pharyngitis: an unusual presentation of acute endemic typhus. (16213963)
2005
36
Evidence-based emergency medicine/rational clinical examination abstract. The clinical diagnosis of streptococcal pharyngitis. (15988434)
2005
37
Pharyngitis clinical prediction rules: effect of interobserver agreement: a MetroNet study. (15125623)
2004
38
Proton pump inhibitor therapy for chronic laryngo-pharyngitis: a randomized placebo-control trial. (15467597)
2004
39
Extracellular matrix-regulated p53 expression and nuclear localization in cultured Detroit 562 cells derived from pharyngeal carcinoma. (15018144)
2003
40
Respiratory failure due to pharyngeal dysfunction: a singular presentation of brainstem listeriosis. (12528037)
2003
41
Validation and modification of streptococcal pharyngitis clinical prediction rules. (12630581)
2003
42
Efficacy of single-dose dexamethasone as adjuvant therapy for acute pharyngitis. (11802044)
2002
43
Diagnosis and treatment of pharyngitis in adults. (17637161)
2002
44
Acute pharyngitis. (11357846)
2001
45
Macrolide therapy of group A streptococcal pharyngitis: 10 days of macrolide therapy (clarithromycin) is more effective in streptococcal eradication than 5 days (azithromycin). (11360224)
2001
46
Bacteriological and clinical efficacy of various antibiotics used in the treatment of streptococcal pharyngitis in Italy. An epidemiological study. (11463521)
2001
47
Pharyngeal carriage of group C and group G streptococci and acute rheumatic fever in an Aboriginal population. (11030302)
2000
48
Periodic fever, aphthous stomatitis, pharyngitis, and adenopathy syndrome: clinical characteristics and outcome. (10393612)
1999
49
Improving diagnostic accuracy of bacterial pharyngitis by near patient measurement of C-reactive protein (CRP) (10326264)
1999
50
Oral and pharyngeal adenosquamous carcinoma. A report of four cases with immunohistochemical studies. (1716111)
1991

Variations for Pharyngitis

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Expression for genes affiliated with Pharyngitis

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Expression patterns in normal tissues for genes affiliated with Pharyngitis

Search GEO for disease gene expression data for Pharyngitis.

Pathways for genes affiliated with Pharyngitis

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Pathways related to Pharyngitis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IL1B, TNF
2
Show member pathways
Serotonin Transporter Activity37
9.9IL1B, TNF
39.9IL1B, TNF
49.9IL1B, TNF
59.8TNF, PTGS2
69.6TNF, FCGR1A, IL1B
7
Show member pathways
9.6TNF, MEFV, IL1B
89.6IL1B, TNF, HLA-DRB1
99.6HLA-DRB1, TNF, IL1B
10
Show member pathways
Immune response MIF in innate immunity response60
9.5TNF, PTGS2, IL1B
119.5TNF, PTGS2, IL1B
129.5IL1B, PTGS2, TNF
139.5IL1B, PTGS2, TNF
14
Show member pathways
thioredoxin pathway37
9.1TNF, PTGS2, IL1B, CRP
159.1CD1A, IL1B, FCGR1A, TNF, HLA-DRB1
16
Show member pathways
8.9HLA-DRB1, TNF, PTGS2, FCGR1A, IL1B
17
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.7KSR1, TNF, PTGS2, IL1B
188.5IL1B, FCGR1A, TNF, KSR1, HLA-DRB1

Compounds for genes affiliated with Pharyngitis

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Compounds related to Pharyngitis according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1tocilizumab44 1111.3TNF, CRP
2cdp5714410.3CRP, TNF
3alefacept44 1111.3TNF, FCGR1A
4n,n-dimethylsphingosine44 6111.2IL1B, TNF
5cicaprost44 2811.2TNF, IL1B
6turpentine4410.2IL1B, CRP
7vesnarinone4410.2TNF, IL1B
8lenalidomide44 1111.1TNF, PTGS2
9taurine chloramine4410.1TNF, IL1B
10adalimumab44 50 1112.1CRP, FCGR1A, TNF
11aceclofenac4410.1IL1B, PTGS2
12bucillamine4410.1CRP, IL1B
13hydroxychloroquine44 1111.1CRP, TNF
14efalizumab44 1111.1TNF, FCGR1A
15gabexate mesilate4410.1CRP, TNF
16rituximab44 50 1112.0CRP, FCGR1A, TNF
17gold sodium thiomalate4410.0IL1B, TNF, HLA-DRB1
18tenidap44 2811.0CRP, IL1B, TNF
19anakinra44 1111.0TNF, IL1B, CRP
20sulprostone44 2811.0PTGS2, IL1B
21infliximab44 50 1111.9CRP, IL1B, TNF
22neopterin449.9CRP, IL1B, TNF
23leflunomide44 50 1111.9IL1B, PTGS2, TNF
24triptolide449.9IL1B, PTGS2, TNF
25ciglitazone44 2810.9TNF, PTGS2, IL1B
26ns 39844 6110.9TNF, PTGS2, IL1B
27ndga449.9IL1B, PTGS2, TNF
28pioglitazone28 44 50 1112.9CRP, PTGS2, TNF
2915-deoxy-delta-12,14-prostaglandin j2449.8TNF, PTGS2, IL1B
30pdtc449.8TNF, PTGS2, IL1B
31thalidomide44 50 61 1112.8IL1B, PTGS2, TNF
32toxin-1449.8TNF, IL1B
33prednisolone44 28 1111.8TNF, FCGR1A, CRP
34ivig449.7TNF, FCGR1A, IL1B, CRP
35pgh2449.7IL1B, PTGS2
36endotoxin449.7CRP, IL1B, MEFV, TNF
37ceftriaxone44 1110.7LACTB, CRP
38herbimycin a44 6110.7TNF, PTGS2, FCGR1A, IL1B
39methotrexate50 44 1111.6CRP, IL1B, TNF, HLA-DRB1
40sulfasalazine28 44 50 1112.6TNF, PTGS2, IL1B, CRP
41prostacyclin449.5TNF, PTGS2, IL1B, CRP
42actinomycin d449.5IL1B, FCGR1A, PTGS2, TNF
43n acetylcysteine449.5TNF, PTGS2, IL1B, CRP
44sb 20358044 6110.5TNF, PTGS2, IL1B, CRP
45ly294002449.5TNF, PTGS2, IL1B, CRP
46genistein44 28 61 2 24 1114.5TNF, PTGS2, FCGR1A, IL1B
47arachidonic acid44 28 24 1112.4TNF, PTGS2, FCGR1A, IL1B
48etanercept44 50 1111.3CRP, IL1B, FCGR1A, PTGS2, TNF
49cycloheximide449.3TNF, PTGS2, FCGR1A, IL1B, CRP
50troglitazone44 28 61 1112.2IL1B, PTGS2, TNF

GO Terms for genes affiliated with Pharyngitis

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Cellular components related to Pharyngitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1clathrin-coated endocytic vesicle membraneGO:0306699.9FCGR1A, HLA-DRB1

Biological processes related to Pharyngitis according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1sequestering of triglycerideGO:03073010.2IL1B, TNF
2negative regulation of lipid storageGO:01088810.2CRP, TNF
3positive regulation of calcidiol 1-monooxygenase activityGO:06055910.2IL1B, TNF
4positive regulation of heterotypic cell-cell adhesionGO:03411610.2TNF, IL1B
5positive regulation of chemokine biosynthetic processGO:04508010.1IL1B, TNF
6regulation of I-kappaB kinase/NF-kappaB signalingGO:04312210.1TNF, IL1B
7positive regulation of membrane protein ectodomain proteolysisGO:05104410.0IL1B, TNF
8negative regulation of lipid catabolic processGO:05099510.0TNF, IL1B
9lipopolysaccharide-mediated signaling pathwayGO:0316639.9IL1B, TNF
10negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.9IL1B, TNF
11positive regulation of fever generationGO:0316229.8IL1B, PTGS2, TNF
12positive regulation of NF-kappaB import into nucleusGO:0423469.8IL1B, PTGS2, TNF
13positive regulation of mitosisGO:0458409.8TNF, IL1B
14positive regulation of nitric oxide biosynthetic processGO:0454299.8TNF, PTGS2, IL1B
15positive regulation vascular endothelial growth factor productionGO:0105759.8IL1B, PTGS2
16protein kinase B signalingGO:0434919.6IL1B, TNF
17immune responseGO:0069559.5CD1A, IL1B, FCGR1A, HLA-DRB1
18negative regulation of cell proliferationGO:0082859.3SPEG, TNF, PTGS2, IL1B
19inflammatory responseGO:0069549.2TNF, PTGS2, MEFV, IL1B, CRP

Products for genes affiliated with Pharyngitis

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Sources for Pharyngitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet