MCID: PHR003
MIFTS: 65

Pharyngitis malady

Respiratory diseases, Oral diseases categories

Summaries for Pharyngitis

About this section
Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Disease Ontology:9 An upper respiratory tract disease involving inflammation of the throat or pharynx resulting from bacterial, viral, fungal infections or irritants like pollutants or chemical substances and smoking. the infection is often referred to as "sore throat". the symptoms include pain during swallowing, enlarged tonsils coated with a white discharge, runny nose, cough and slight fever.

MalaCards: Pharyngitis, also known as chronic pharyngitis, is related to tonsillitis and cervical adenitis. An important gene associated with Pharyngitis is ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide), and among its related pathways are LDL Oxidation in Atherogenesis and Monoamine Transport. The drugs guaifenesin and cefditoren and the compounds tocilizumab and cdp571 have been mentioned in the context of this disorder. Affiliated tissues include tonsil, testes and heart, and related mouse phenotypes are skeleton and immune system.

Wikipedia:66 The word pharyngitis /f more...

Aliases & Classifications for Pharyngitis

About this section
Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 28ICD9CM, 41NCIt, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases, Oral diseases


Aliases & Descriptions:

pharyngitis 9 11 46 63
chronic pharyngitis 9 63
acute pharyngitis 9 63
chronic pharyngitis and nasopharyngitis nos 9
chronic pharyngitis and nasopharyngitis 9
chronic pharyn/nasopharyngitis 9
chronic pharyngitis nos 9
persistent sore throat 9
acute sore throat nos 9
sore throat - chronic 9
pharyngeal disorder 9
pharyngitis - acute 9
disorder of pharynx 9
chronic sore throat 9
pharyngeal diseases 63
acute sore throat 9
inflamed throat 9


Related Diseases for Pharyngitis

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Pharyngitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 311)
idRelated DiseaseScoreTop Affiliating Genes
1tonsillitis30.9KSR1, CRP, LACTB, HSF4
2cervical adenitis30.9HSF4
3otitis media30.2IL1B, LACTB
4arthritis30.2IL1B, TNF
5pneumonia30.2LACTB, TNF, IL1B, CRP, HSF4
6bacteremia30.2CRP, LACTB
7respiratory failure30.1CRP, TNF, IL1B
8adult-onset still's disease30.1CRP
9toxic shock syndrome30.1SPEG, TNF, IL1B, LACTB
10meningitis30.0IL1B, LACTB, CRP
11bronchitis30.0CRP, HSF4
12sepsis30.0FCGR1A, IL1B, TNF, CRP, LACTB
13parotitis29.9HSF4
14erysipelas29.9MEFV
15asthma29.9TNF, IL1B, CD1A, HLA-DRB1
16familial mediterranean fever29.9MEFV, TNF
17mediastinitis29.8CRP
18septic arthritis29.8CRP
19osteomyelitis29.8CRP, LACTB
20tuberculosis29.8IL1B, TNF, CRP, LACTB, HLA-DRB1, CD1A
21leukemia29.6HLA-DRB1, TNF, IL1B, CD1A, LACTB
22rheumatoid arthritis29.4CRP, IL1B, HLA-DRB1, PTGS2, TNF, FCGR1A
23stomatitis10.6
24aphthous stomatitis10.6
25laryngitis10.6
26cervicitis10.6
27periodic fever, aphthous stomatitis, pharyngitis and adenitis10.5
28gonorrhea10.4
29dysphagia10.3
30rheumatic fever10.3
31blindness10.3
32sleep apnea10.3
33digeorge syndrome10.3
34esophagitis10.3
35rheumatic heart disease10.3
36obstructive sleep apnea10.2
37velocardiofacial syndrome10.2
38lemierre's syndrome10.2
39impetigo10.2
40sarcoma10.2
41swallowing disorders10.2
42palindromic rheumatism10.1MEFV
43polyarteritis nodosa10.1MEFV
44endophthalmitis10.1LACTB
45oculopharyngeal muscular dystrophy10.1
46scarlet fever10.1
47nasopharyngitis10.1
48esophageal atresia10.1
49laryngeal carcinoma10.1
50muscular dystrophy10.1

Graphical network of the top 20 diseases related to Pharyngitis:



Diseases related to pharyngitis

Symptoms for Pharyngitis

About this section

Drugs & Therapeutics for Pharyngitis

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pharyngitis

Drug clinical trials:

Search ClinicalTrials for Pharyngitis

Search NIH Clinical Center for Pharyngitis

Search CenterWatch for Pharyngitis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Pharyngitis

About this section

Anatomical Context for Pharyngitis

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Pharyngitis:

34
Tonsil, Testes, Heart, Bone, Endothelial, Cortex, Colon, Monocytes, Salivary gland, Thyroid, Lymph node, Lung, Pituitary, Myeloid

Animal Models for Pharyngitis or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Pharyngitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.1KSR1, TNF, PTGS2, FCGR1A, MEFV, IL1B
2MP:00053877.3KSR1, TNF, PTGS2, FCGR1A, ADH5, MEFV

Publications for Pharyngitis

About this section
Sources:
53PubMed
See all sources

Articles related to Pharyngitis:

(show top 50)    (show all 799)
idTitleAuthorsYear
1
A probable food-borne outbreak of pharyngitis after a massive rainstorm in Beijing, caused by emm89 group A Streptococcus rarely found in China. (23375890)
2013
2
Necrotic pharyngitis associated with Mycoplasma bovis infections in American bison (Bison bison). (23512925)
2013
3
Halzoun, an allergic pharyngitis syndrome in Lebanon: the trematode Dicrocoelium dendriticum as an additional cause. (23022355)
2013
4
About group A streptococcal pharyngitis guidelines. (23550388)
2013
5
Management of adults with acute streptococcal pharyngitis: minimal value for backup strep testing and overuse of antibiotics. (23054930)
2013
6
A retrospective comparative study of 2-drug oral and intramuscular cephalosporin treatment regimens for pharyngeal gonorrhea. (23408680)
2013
7
Elevated levels of CXCL10 in the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis syndrome (PFAPA) during and between febrile episodes; an indication of a persistent activation of the innate immune system. (24134207)
2013
8
Three-dimensional analysis of the pharyngeal airway morphology in growing Japanese girls with and without cleft lip and palate. (22449605)
2012
9
A case of resistant adult-onset periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome responsive to anakinra. (22931584)
2012
10
Dose-response analysis of acute oral mucositis and pharyngeal dysphagia in patients receiving induction chemotherapy followed by concomitant chemo-IMRT for head and neck cancer. (22280809)
2012
11
Percutaneous endoscopic gastrostomy feeding--a life-saving intervention in SSc-myositis overlap with pharyngeal dysfunction. (22461389)
2012
12
Val66Met in brain-derived neurotrophic factor affects stimulus-induced plasticity in the human pharyngeal motor cortex. (21699787)
2011
13
Adolescent pharyngitis: a review of bacterial causes. (21646249)
2011
14
Transtubal photo of the middle ear in a newborn after removal of a pharyngeal teratoma. (21493335)
2011
15
Epidemiological characterization of Streptococcus pyogenes isolated from patients with multiple onsets of pharyngitis. (21362024)
2011
16
Down-regulation of EBV-LMP1 radio-sensitizes nasal pharyngeal carcinoma cells via NF-I_B regulated ATM expression. (22096476)
2011
17
Antimicrobial prescribing in the USA for adult acute pharyngitis in relation to treatment guidelines. (20586844)
2011
18
Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA). (20824883)
2010
19
Appropriately prescribing antibiotics for patients with pharyngitis: a physician-based approach vs a nurse-only triage and treatment algorithm. (21037044)
2010
20
The evaluation of SD Bioline Strep A rapid antigen test in acute pharyngitis in pediatric clinics. (19726894)
2009
21
Seven-year surveillance of north american pediatric group a streptococcal pharyngitis isolates. (19480575)
2009
22
Two siblings with periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA) syndrome. (19209090)
2009
23
Case of the month. Streptococcal pharyngitis and infectious mononucleosis. (18795552)
2008
24
Psoriasiform eruption and pharyngitis. (18283187)
2008
25
Symptomatic treatment of acute tonsillo-pharyngitis patients with a combination of Nigella sativa and Phyllanthus niruri extract. (18541126)
2008
26
Severe pharyngitis in stockbreeders: an unusual presentation of brucellosis. (18397911)
2008
27
A food-borne outbreak of streptococcal pharyngitis. (18847165)
2008
28
The evidence base for cephalosporin superiority over penicillin in streptococcal pharyngitis. (17292576)
2007
29
Quality of care in the retail health care setting using national clinical guidelines for acute pharyngitis. (18006426)
2007
30
Biotypes of group A streptococci from patients with pharyngitis and soft tissue infections. (17391389)
2007
31
Prevalence and incidence of pharyngeal gonorrhea in a longitudinal sample of men who have sex with men: the EXPLORE study. (17051493)
2006
32
Helicobacter pylori infection in the pharynx of patients with chronic pharyngitis detected with TDI-FP and modified Giemsa stain. (16489652)
2006
33
Orbital myositis following streptococcal pharyngitis in a pediatric patient. (15832845)
2005
34
Acute pharyngitis: an unusual presentation of acute endemic typhus. (16213963)
2005
35
Evidence-based emergency medicine/rational clinical examination abstract. The clinical diagnosis of streptococcal pharyngitis. (15988434)
2005
36
Pharyngitis clinical prediction rules: effect of interobserver agreement: a MetroNet study. (15125623)
2004
37
Proton pump inhibitor therapy for chronic laryngo-pharyngitis: a randomized placebo-control trial. (15467597)
2004
38
Extracellular matrix-regulated p53 expression and nuclear localization in cultured Detroit 562 cells derived from pharyngeal carcinoma. (15018144)
2003
39
Respiratory failure due to pharyngeal dysfunction: a singular presentation of brainstem listeriosis. (12528037)
2003
40
Validation and modification of streptococcal pharyngitis clinical prediction rules. (12630581)
2003
41
Utility of tonsillectomy in 2 patients with the syndrome of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis. (12810475)
2003
42
Efficacy of single-dose dexamethasone as adjuvant therapy for acute pharyngitis. (11802044)
2002
43
Diagnosis and treatment of pharyngitis in adults. (17637161)
2002
44
Acute pharyngitis. (11357846)
2001
45
Macrolide therapy of group A streptococcal pharyngitis: 10 days of macrolide therapy (clarithromycin) is more effective in streptococcal eradication than 5 days (azithromycin). (11360224)
2001
46
Pharyngeal carriage of group C and group G streptococci and acute rheumatic fever in an Aboriginal population. (11030302)
2000
47
Periodic fever, aphthous stomatitis, pharyngitis, and adenopathy syndrome: clinical characteristics and outcome. (10393612)
1999
48
Improving diagnostic accuracy of bacterial pharyngitis by near patient measurement of C-reactive protein (CRP) (10326264)
1999
49
Oral and pharyngeal adenosquamous carcinoma. A report of four cases with immunohistochemical studies. (1716111)
1991
50
Streptococcal pharyngitis and scarlet fever. (655147)
1978

Variations for Pharyngitis

About this section

Expression for genes affiliated with Pharyngitis

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pharyngitis

Search GEO for disease gene expression data for Pharyngitis.

Pathways for genes affiliated with Pharyngitis

About this section
Sources:
51PathCards, 54QIAGEN, 39NCBI BioSystems Database, 61Thomson Reuters, 31KEGG, 56Reactome, 5Cell Signaling Technology, 55R&D Systems
See all sources

Pathways related to Pharyngitis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IL1B, TNF
2
Show member pathways
Serotonin Transporter Activity39
9.9IL1B, TNF
39.9IL1B, TNF
49.9IL1B, TNF
59.8TNF, PTGS2
69.6TNF, FCGR1A, IL1B
7
Show member pathways
9.6TNF, MEFV, IL1B
89.6IL1B, TNF, HLA-DRB1
99.6HLA-DRB1, TNF, IL1B
10
Show member pathways
Immune response MIF in innate immunity response61
9.5TNF, PTGS2, IL1B
119.5TNF, PTGS2, IL1B
129.5IL1B, PTGS2, TNF
139.5IL1B, PTGS2, TNF
14
Show member pathways
thioredoxin pathway39
9.1TNF, PTGS2, IL1B, CRP
159.1CD1A, IL1B, FCGR1A, TNF, HLA-DRB1
16
Show member pathways
8.9HLA-DRB1, TNF, PTGS2, FCGR1A, IL1B
17
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
8.7KSR1, TNF, PTGS2, IL1B
188.5IL1B, FCGR1A, TNF, KSR1, HLA-DRB1

Compounds for genes affiliated with Pharyngitis

About this section
Sources:
46Novoseek, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 52PharmGKB, 3BitterDB, 25HMDB
See all sources

Compounds related to Pharyngitis according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1tocilizumab46 1211.3TNF, CRP
2cdp5714610.3CRP, TNF
3alefacept46 1211.3TNF, FCGR1A
4n,n-dimethylsphingosine46 6211.2IL1B, TNF
5cicaprost46 3011.2IL1B, TNF
6turpentine4610.2IL1B, CRP
7vesnarinone4610.2TNF, IL1B
8taurine chloramine4610.2TNF, IL1B
9lenalidomide46 1211.1PTGS2, TNF
10adalimumab46 52 1212.1TNF, CRP, FCGR1A
11aceclofenac4610.1PTGS2, IL1B
12bucillamine4610.1IL1B, CRP
13gabexate mesilate4610.1CRP, TNF
14hydroxychloroquine46 1211.1TNF, CRP
15rituximab46 52 1212.0FCGR1A, CRP, TNF
16efalizumab46 1211.0FCGR1A, TNF
17gold sodium thiomalate4610.0IL1B, TNF, HLA-DRB1
18tenidap46 3011.0CRP, IL1B, TNF
19anakinra46 1211.0TNF, IL1B, CRP
20sulprostone46 3010.9IL1B, PTGS2
21infliximab46 52 1211.9CRP, IL1B, TNF
22neopterin469.9CRP, IL1B, TNF
23leflunomide46 52 1211.9PTGS2, TNF, IL1B
24triptolide469.9PTGS2, TNF, IL1B
25ciglitazone46 3010.9PTGS2, IL1B, TNF
26ns 39846 6210.9TNF, PTGS2, IL1B
27ndga469.9PTGS2, IL1B, TNF
28pioglitazone30 46 52 1212.9CRP, PTGS2, TNF
2915-deoxy-delta-12,14-prostaglandin j2469.8PTGS2, TNF, IL1B
30pdtc469.8TNF, PTGS2, IL1B
31thalidomide46 52 62 1212.8IL1B, PTGS2, TNF
32toxin-1469.8TNF, IL1B
33prednisolone46 30 1211.8FCGR1A, CRP, TNF
34ivig469.7IL1B, FCGR1A, TNF, CRP
35ceftriaxone46 1210.7LACTB, CRP
36pgh2469.7PTGS2, IL1B
37endotoxin469.7TNF, MEFV, IL1B, CRP
38herbimycin a46 6210.7IL1B, FCGR1A, PTGS2, TNF
39methotrexate52 46 1211.6TNF, IL1B, CRP, HLA-DRB1
40sulfasalazine30 46 52 1212.6TNF, CRP, PTGS2, IL1B
41prostacyclin469.5PTGS2, CRP, IL1B, TNF
42actinomycin d469.5IL1B, TNF, PTGS2, FCGR1A
43n acetylcysteine469.5PTGS2, IL1B, CRP, TNF
44sb 20358046 6210.5IL1B, PTGS2, TNF, CRP
45ly294002469.5IL1B, TNF, CRP, PTGS2
46genistein46 30 62 3 25 1214.5IL1B, TNF, PTGS2, FCGR1A
47arachidonic acid46 30 25 1212.4TNF, PTGS2, IL1B, FCGR1A
48etanercept46 52 1211.3CRP, IL1B, FCGR1A, PTGS2, TNF
49cycloheximide469.3PTGS2, TNF, FCGR1A, IL1B, CRP
50troglitazone46 30 62 1212.2PTGS2, TNF, IL1B

GO Terms for genes affiliated with Pharyngitis

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Pharyngitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1clathrin-coated endocytic vesicle membraneGO:0306699.9FCGR1A, HLA-DRB1

Biological processes related to Pharyngitis according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1sequestering of triglycerideGO:03073010.2IL1B, TNF
2negative regulation of lipid storageGO:01088810.2CRP, TNF
3positive regulation of calcidiol 1-monooxygenase activityGO:06055910.2IL1B, TNF
4positive regulation of heterotypic cell-cell adhesionGO:03411610.2TNF, IL1B
5positive regulation of chemokine biosynthetic processGO:04508010.1IL1B, TNF
6regulation of I-kappaB kinase/NF-kappaB signalingGO:04312210.1TNF, IL1B
7positive regulation of membrane protein ectodomain proteolysisGO:05104410.0IL1B, TNF
8negative regulation of lipid catabolic processGO:05099510.0TNF, IL1B
9lipopolysaccharide-mediated signaling pathwayGO:0316639.9IL1B, TNF
10negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.9IL1B, TNF
11positive regulation of fever generationGO:0316229.8IL1B, PTGS2, TNF
12positive regulation of NF-kappaB import into nucleusGO:0423469.8IL1B, PTGS2, TNF
13positive regulation of mitosisGO:0458409.8TNF, IL1B
14positive regulation of nitric oxide biosynthetic processGO:0454299.8TNF, PTGS2, IL1B
15positive regulation vascular endothelial growth factor productionGO:0105759.8IL1B, PTGS2
16protein kinase B signalingGO:0434919.6IL1B, TNF
17immune responseGO:0069559.5CD1A, IL1B, FCGR1A, HLA-DRB1
18negative regulation of cell proliferationGO:0082859.3SPEG, TNF, PTGS2, IL1B
19inflammatory responseGO:0069549.2TNF, PTGS2, MEFV, IL1B, CRP

Products for genes affiliated with Pharyngitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pharyngitis

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet