MCID: PHR003
MIFTS: 65

Pharyngitis malady

Respiratory diseases, Oral diseases categories

Summaries for Pharyngitis

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Disease Ontology:10 An upper respiratory tract disease involving inflammation of the throat or pharynx resulting from bacterial, viral, fungal infections or irritants like pollutants or chemical substances and smoking. the infection is often referred to as "sore throat". the symptoms include pain during swallowing, enlarged tonsils coated with a white discharge, runny nose, cough and slight fever.

MalaCards based summary: Pharyngitis, also known as persistent sore throat, is related to tonsillitis and cervical adenitis. An important gene associated with Pharyngitis is ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide), and among its related pathways are LDL Oxidation in Atherogenesis and Cytokine Network. The drugs guaifenesin and cefditoren and the compounds tocilizumab and cdp571 have been mentioned in the context of this disorder. Affiliated tissues include tonsil, testes and heart, and related mouse phenotypes are skeleton and immune system.

Wikipedia:65 Pharyngitis /f more...

Aliases & Classifications for Pharyngitis

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Sources:
10Disease Ontology, 12DISEASES, 45Novoseek, 62UMLS, 57SNOMED-CT, 40NCIt, 29ICD9CM, 27ICD10
See all sources

Pharyngitis, Aliases & Descriptions:

Name: Pharyngitis 10 12 45 62
Persistent Sore Throat 10 62
Chronic Pharyngitis 10 62
Acute Pharyngitis 10 62
Inflamed Throat 10 62
Chronic Pharyngitis and Nasopharyngitis 10
Chronic Pharyn/nasopharyngitis 10
 
Acute Sore Throat Nos 10
Sore Throat - Chronic 10
Pharyngeal Disorder 10
Pharyngitis - Acute 10
Pharyngeal Diseases 62
Chronic Sore Throat 10
Acute Sore Throat 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases, Oral diseases


Related Diseases for Pharyngitis

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Diseases related to Pharyngitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 323)
idRelated DiseaseScoreTop Affiliating Genes
1tonsillitis31.0KSR1, CRP, LACTB, HSF4
2cervical adenitis30.9HSF4
3pneumonia30.4LACTB, TNF, IL1B, CRP, HSF4
4otitis media30.2IL1B, LACTB
5arthritis30.2IL1B, TNF
6respiratory failure30.2CRP, TNF, IL1B
7adult-onset still's disease30.2CRP
8bacteremia30.1CRP, LACTB
9toxic shock syndrome30.1SPEG, TNF, IL1B, LACTB
10meningitis30.1IL1B, LACTB, CRP
11bronchitis30.0CRP, HSF4
12asthma29.9TNF, IL1B, CD1A, HLA-DRB1
13tuberculosis29.9IL1B, TNF, CRP, LACTB, HLA-DRB1, CD1A
14parotitis29.8HSF4
15erysipelas29.8MEFV
16mediastinitis29.8CRP
17septic arthritis29.8CRP
18osteomyelitis29.8CRP, LACTB
19malaria29.7TNF, IL1B
20systemic lupus erythematosus29.7CRP, FCGR1A, TNF, HLA-DRB1
21colitis29.7IL1B, TNF, PTGS2
22leukemia29.7HLA-DRB1, TNF, IL1B, CD1A, LACTB
23rheumatoid arthritis29.6CRP, IL1B, HLA-DRB1, PTGS2, TNF, FCGR1A
24stomatitis10.7
25aphthous stomatitis10.7
26cervicitis10.6
27laryngitis10.6
28periodic fever, aphthous stomatitis, pharyngitis and adenitis10.6
29gonorrhea10.4
30dysphagia10.4
31rheumatic fever10.4
32blindness10.3
33sleep apnea10.3
34digeorge syndrome10.3
35rheumatic heart disease10.3
36esophagitis10.3
37velocardiofacial syndrome10.2
38obstructive sleep apnea10.2
39lemierre's syndrome10.2
40impetigo10.2
41sinusitis10.2
42laryngeal carcinoma10.2
43sarcoma10.2
44swallowing disorders10.2
45oculopharyngeal muscular dystrophy10.1
46herpangina10.1
47epiglottitis10.1
48scarlet fever10.1
49nasopharyngitis10.1
50esophageal atresia10.1

Graphical network of the top 20 diseases related to Pharyngitis:



Diseases related to pharyngitis

Symptoms for Pharyngitis

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Drugs & Therapeutics for Pharyngitis

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Drug clinical trials:

Search ClinicalTrials for Pharyngitis

Search NIH Clinical Center for Pharyngitis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Pharyngitis

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Anatomical Context for Pharyngitis

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MalaCards organs/tissues related to Pharyngitis:

33
Tonsil, Testes, Heart, Bone, Endothelial, Cortex, Colon, Monocytes, Neutrophil, Lymph node, Salivary gland, Lung, Thyroid, Myeloid, T cells, Pituitary

Animal Models for Pharyngitis or affiliated genes

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MGI Mouse Phenotypes related to Pharyngitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.1IL1B, MEFV, FCGR1A, PTGS2, TNF, KSR1
2MP:00053877.3CRP, KSR1, TNF, PTGS2, FCGR1A, ADH5

Publications for Pharyngitis

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Articles related to Pharyngitis:

(show top 50)    (show all 858)
idTitleAuthorsYear
1
Klebsiella pneumoniae in a patient with hoarseness and dysphagia rather than pharyngitis. (25623636)
2015
2
Expect the Unexpected: Report of a Case of Pediatric Pharyngeal Extraosseous Plasmacytoma with Tumefactive Amyloidosis ("Amyloidoma") and a Review of the Literature. (25672253)
2015
3
Variability in the diagnosis and treatment of group a streptococcal pharyngitis by primary care pediatricians. (25222902)
2014
4
Parathyroid adenoma in third pharyngeal pouch cyst as a rare case of primary hyperparathyroidism. (25245714)
2014
5
Measures of user experience in a streptococcal pharyngitis and pneumonia clinical decision support tools. (25298820)
2014
6
Primary care management of group A streptococcal pharyngitis in Northland. (25194245)
2014
7
Tea intake and risk of oral, pharyngeal, and laryngeal carcinoma: a meta-analysis. (25363316)
2014
8
A probable food-borne outbreak of pharyngitis after a massive rainstorm in Beijing, caused by emm89 group A Streptococcus rarely found in China. (23375890)
2013
9
Necrotic pharyngitis associated with Mycoplasma bovis infections in American bison (Bison bison). (23512925)
2013
10
Halzoun, an allergic pharyngitis syndrome in Lebanon: the trematode Dicrocoelium dendriticum as an additional cause. (23022355)
2013
11
About group A streptococcal pharyngitis guidelines. (23550388)
2013
12
Management of adults with acute streptococcal pharyngitis: minimal value for backup strep testing and overuse of antibiotics. (23054930)
2013
13
A retrospective comparative study of 2-drug oral and intramuscular cephalosporin treatment regimens for pharyngeal gonorrhea. (23408680)
2013
14
Elevated levels of CXCL10 in the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis syndrome (PFAPA) during and between febrile episodes; an indication of a persistent activation of the innate immune system. (24134207)
2013
15
Three-dimensional analysis of the pharyngeal airway morphology in growing Japanese girls with and without cleft lip and palate. (22449605)
2012
16
A case of resistant adult-onset periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome responsive to anakinra. (22931584)
2012
17
Dose-response analysis of acute oral mucositis and pharyngeal dysphagia in patients receiving induction chemotherapy followed by concomitant chemo-IMRT for head and neck cancer. (22280809)
2012
18
Percutaneous endoscopic gastrostomy feeding--a life-saving intervention in SSc-myositis overlap with pharyngeal dysfunction. (22461389)
2012
19
The involvement of RCAS1 in creating a suppressive tumor microenvironment in patients with pharyngeal squamous cell carcinoma]. (23164108)
2012
20
Val66Met in brain-derived neurotrophic factor affects stimulus-induced plasticity in the human pharyngeal motor cortex. (21699787)
2011
21
Adolescent pharyngitis: a review of bacterial causes. (21646249)
2011
22
Transtubal photo of the middle ear in a newborn after removal of a pharyngeal teratoma. (21493335)
2011
23
Epidemiological characterization of Streptococcus pyogenes isolated from patients with multiple onsets of pharyngitis. (21362024)
2011
24
Down-regulation of EBV-LMP1 radio-sensitizes nasal pharyngeal carcinoma cells via NF-I_B regulated ATM expression. (22096476)
2011
25
Antimicrobial prescribing in the USA for adult acute pharyngitis in relation to treatment guidelines. (20586844)
2011
26
Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA). (20824883)
2010
27
The evaluation of SD Bioline Strep A rapid antigen test in acute pharyngitis in pediatric clinics. (19726894)
2009
28
Seven-year surveillance of north american pediatric group a streptococcal pharyngitis isolates. (19480575)
2009
29
Two siblings with periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA) syndrome. (19209090)
2009
30
Case of the month. Streptococcal pharyngitis and infectious mononucleosis. (18795552)
2008
31
Psoriasiform eruption and pharyngitis. (18283187)
2008
32
Symptomatic treatment of acute tonsillo-pharyngitis patients with a combination of Nigella sativa and Phyllanthus niruri extract. (18541126)
2008
33
The evidence base for cephalosporin superiority over penicillin in streptococcal pharyngitis. (17292576)
2007
34
Quality of care in the retail health care setting using national clinical guidelines for acute pharyngitis. (18006426)
2007
35
Prevalence and incidence of pharyngeal gonorrhea in a longitudinal sample of men who have sex with men: the EXPLORE study. (17051493)
2006
36
Orbital myositis following streptococcal pharyngitis in a pediatric patient. (15832845)
2005
37
Acute pharyngitis: an unusual presentation of acute endemic typhus. (16213963)
2005
38
Pharyngitis clinical prediction rules: effect of interobserver agreement: a MetroNet study. (15125623)
2004
39
Proton pump inhibitor therapy for chronic laryngo-pharyngitis: a randomized placebo-control trial. (15467597)
2004
40
Extracellular matrix-regulated p53 expression and nuclear localization in cultured Detroit 562 cells derived from pharyngeal carcinoma. (15018144)
2003
41
Respiratory failure due to pharyngeal dysfunction: a singular presentation of brainstem listeriosis. (12528037)
2003
42
Validation and modification of streptococcal pharyngitis clinical prediction rules. (12630581)
2003
43
Efficacy of single-dose dexamethasone as adjuvant therapy for acute pharyngitis. (11802044)
2002
44
Diagnosis and treatment of pharyngitis in adults. (17637161)
2002
45
Macrolide therapy of group A streptococcal pharyngitis: 10 days of macrolide therapy (clarithromycin) is more effective in streptococcal eradication than 5 days (azithromycin). (11360224)
2001
46
Bacteriological and clinical efficacy of various antibiotics used in the treatment of streptococcal pharyngitis in Italy. An epidemiological study. (11463521)
2001
47
Pharyngeal carriage of group C and group G streptococci and acute rheumatic fever in an Aboriginal population. (11030302)
2000
48
Periodic fever, aphthous stomatitis, pharyngitis, and adenopathy syndrome: clinical characteristics and outcome. (10393612)
1999
49
Improving diagnostic accuracy of bacterial pharyngitis by near patient measurement of C-reactive protein (CRP) (10326264)
1999
50
Oral and pharyngeal adenosquamous carcinoma. A report of four cases with immunohistochemical studies. (1716111)
1991

Variations for Pharyngitis

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Expression for genes affiliated with Pharyngitis

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Search GEO for disease gene expression data for Pharyngitis.

Pathways for genes affiliated with Pharyngitis

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Pathways related to Pharyngitis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9TNF, IL1B
29.9TNF, IL1B
39.9TNF, IL1B
4
Show member pathways
Serotonin Transporter Activity38
9.9IL1B, TNF
59.8PTGS2, TNF
69.6IL1B, TNF, FCGR1A
7
Show member pathways
9.6IL1B, MEFV, TNF
89.6TNF, HLA-DRB1, IL1B
99.6TNF, HLA-DRB1, IL1B
10
Show member pathways
Immune response MIF in innate immunity response60
9.5TNF, PTGS2, IL1B
119.5TNF, IL1B, PTGS2
129.5IL1B, TNF, PTGS2
139.5IL1B, PTGS2, TNF
14
Show member pathways
thioredoxin pathway38
9.1CRP, TNF, PTGS2, IL1B
159.1FCGR1A, TNF, HLA-DRB1, IL1B, CD1A
16
Show member pathways
8.9HLA-DRB1, TNF, FCGR1A, IL1B, PTGS2
17
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.7KSR1, IL1B, TNF, PTGS2
188.5IL1B, FCGR1A, TNF, KSR1, HLA-DRB1

Compounds for genes affiliated with Pharyngitis

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Compounds related to Pharyngitis according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1tocilizumab45 1311.3TNF, CRP
2cdp5714510.3CRP, TNF
3alefacept45 1311.3TNF, FCGR1A
4n,n-dimethylsphingosine45 6111.2IL1B, TNF
5cicaprost45 3011.2TNF, IL1B
6turpentine4510.2IL1B, CRP
7vesnarinone4510.2TNF, IL1B
8lenalidomide45 1311.1TNF, PTGS2
9taurine chloramine4510.1TNF, IL1B
10adalimumab45 51 1312.1CRP, FCGR1A, TNF
11aceclofenac4510.1IL1B, PTGS2
12bucillamine4510.1CRP, IL1B
13hydroxychloroquine45 1311.1CRP, TNF
14efalizumab45 1311.1TNF, FCGR1A
15gabexate mesilate4510.1CRP, TNF
16rituximab45 51 1312.0CRP, FCGR1A, TNF
17gold sodium thiomalate4510.0IL1B, TNF, HLA-DRB1
18tenidap45 3011.0CRP, IL1B, TNF
19anakinra45 1311.0TNF, IL1B, CRP
20sulprostone45 3011.0PTGS2, IL1B
21infliximab45 51 1311.9CRP, IL1B, TNF
22neopterin459.9CRP, IL1B, TNF
23leflunomide45 51 1311.9IL1B, PTGS2, TNF
24triptolide459.9IL1B, PTGS2, TNF
25ciglitazone45 3010.9TNF, PTGS2, IL1B
26ns 39845 6110.9TNF, PTGS2, IL1B
27ndga459.9IL1B, PTGS2, TNF
28pioglitazone30 45 51 1312.9CRP, PTGS2, TNF
2915-deoxy-delta-12,14-prostaglandin j2459.8TNF, PTGS2, IL1B
30pdtc459.8TNF, PTGS2, IL1B
31thalidomide45 51 61 1312.8IL1B, PTGS2, TNF
32toxin-1459.8TNF, IL1B
33prednisolone45 30 1311.8TNF, FCGR1A, CRP
34ivig459.7TNF, FCGR1A, IL1B, CRP
35pgh2459.7IL1B, PTGS2
36endotoxin459.7CRP, IL1B, MEFV, TNF
37ceftriaxone45 1310.7LACTB, CRP
38herbimycin a45 6110.7TNF, PTGS2, FCGR1A, IL1B
39methotrexate51 45 1311.6CRP, IL1B, TNF, HLA-DRB1
40sulfasalazine30 45 51 1312.6TNF, PTGS2, IL1B, CRP
41prostacyclin459.5TNF, PTGS2, IL1B, CRP
42actinomycin d459.5IL1B, FCGR1A, PTGS2, TNF
43n acetylcysteine459.5TNF, PTGS2, IL1B, CRP
44sb 20358045 6110.5TNF, PTGS2, IL1B, CRP
45ly294002459.5TNF, PTGS2, IL1B, CRP
46genistein45 30 61 3 26 1314.5TNF, PTGS2, FCGR1A, IL1B
47arachidonic acid45 30 26 1312.4TNF, PTGS2, FCGR1A, IL1B
48etanercept45 51 1311.3CRP, IL1B, FCGR1A, PTGS2, TNF
49cycloheximide459.3TNF, PTGS2, FCGR1A, IL1B, CRP
50troglitazone45 30 61 1312.2IL1B, PTGS2, TNF

GO Terms for genes affiliated with Pharyngitis

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Cellular components related to Pharyngitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1clathrin-coated endocytic vesicle membraneGO:00306699.9FCGR1A, HLA-DRB1

Biological processes related to Pharyngitis according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1sequestering of triglycerideGO:003073010.2IL1B, TNF
2negative regulation of lipid storageGO:001088810.2CRP, TNF
3positive regulation of calcidiol 1-monooxygenase activityGO:006055910.2IL1B, TNF
4positive regulation of heterotypic cell-cell adhesionGO:003411610.2TNF, IL1B
5positive regulation of chemokine biosynthetic processGO:004508010.1IL1B, TNF
6regulation of I-kappaB kinase/NF-kappaB signalingGO:004312210.1TNF, IL1B
7positive regulation of membrane protein ectodomain proteolysisGO:005104410.0IL1B, TNF
8negative regulation of lipid catabolic processGO:005099510.0TNF, IL1B
9lipopolysaccharide-mediated signaling pathwayGO:00316639.9IL1B, TNF
10negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:020012409.9IL1B, TNF
11positive regulation of fever generationGO:00316229.8IL1B, PTGS2, TNF
12positive regulation of NF-kappaB import into nucleusGO:00423469.8IL1B, PTGS2, TNF
13positive regulation of mitosisGO:00458409.8TNF, IL1B
14positive regulation of nitric oxide biosynthetic processGO:00454299.8TNF, PTGS2, IL1B
15positive regulation vascular endothelial growth factor productionGO:00105759.8IL1B, PTGS2
16protein kinase B signalingGO:00434919.6IL1B, TNF
17immune responseGO:00069559.5CD1A, IL1B, FCGR1A, HLA-DRB1
18negative regulation of cell proliferationGO:00082859.3SPEG, TNF, PTGS2, IL1B
19inflammatory responseGO:00069549.2TNF, PTGS2, MEFV, IL1B, CRP

Products for genes affiliated with Pharyngitis

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Sources for Pharyngitis

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet