Pharyngitis malady

Disease Ontology: An upper respiratory tract disease involving inflammation of the throat or pharynx resulting from bacterial, viral, fungal infections or irritants like pollutants or chemical substances and smoking. the infection is often referred to as "sore throat". the symptoms include pain during swallowing, enlarged tonsils coated with a white discharge, runny nose, cough and slight fever.⁶

MalaCards: Pharyngitis, also known as chronic pharyngitis, is related to carcinoma and neuronitis. An important gene associated with Pharyngitis is MATR3 (matrin 3), and among its related pathways are Neuroactive ligand-receptor interaction and cAMP Pathway. The drugs cefprozil and cefaclor monohydrate and the compounds calcium and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include lymph node, brain and cortex, and related mouse phenotypes are mortality/aging and growth/size.

Wikipedia: Pharyngitis (pron.: /færɨnˈdʒaɪtɨs/) comes from the Latin word pharynx pharanx meaning throat and...⁴⁴ more...

Aliases & Descriptions:

pharyngitis 6 8 32 43 chronic pharyngitis 6 43 acute pharyngitis 6 43 chronic pharyngitis and nasopharyngitis nos (disorder) 6 chronic pharyngitis and nasopharyngitis 6 chronic pharyngitis nos (disorder) 6 disorder of pharynx (disorder) 6 chronic pharyn/nasopharyngitis 6 acute pharyngitis (disorder) 6 pharyngitis (disorder) 6

persistent sore throat 6 acute sore throat nos 6 sore throat - chronic 6 pharyngitis - acute 6 chronic sore throat 6 pharyngeal disorder 6 pharyngeal diseases 43 acute sore throat 6 inflamed throat 6

Diseases related to pharyngitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 585)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	50.1	PIK3CA, LRIG1, KITLG, PCSK2, PCNA, PCSK6
2	neuronitis	34.2	ZNF462, ZNF513, ZNF142, PIK3CA, PICALM, KLHL2
3	myopathy	32.3	VIM, MYH1, MYOT, PABPN1, BDNF, BCL2
4	alcoholism	32.0	CHRM2, FYN, HTR1A, HTR1B, HTR2A, HTR2C
5	digeorge syndrome	31.6	CD79A, GSC2, ALDH1A2, TBX1, TBX10, TBX3
6	squamous cell carcinoma	31.4	PIK3CA, PCSK2, PCNA, PCSK6, RBL2, RBL1
7	tonsillitis	29.9	VIM, VEGFA, BDNF, BCL2, MUC1, LACTB
8	laryngitis	29.7	PIK3CA, PCNA, VIM, NAT1, NAT2, VEGFA
9	ataxia	28.7	PIK3CA, PCNA, PCSK5, PCSK6, RBFOX1, RBFOX2
10	muscular dystrophy	28.6	VIM, VEGFA, LMO7, MYPN, MYOT, PABPN1
11	rheumatic fever	28.4	MYOM2, CD79A, CDKN2A, ALB, CAT, HP
12	guillain-barre syndrome	28.2	CD79A, CD1A, MMP9, HP, HLA-DRB1, TNF
13	adenosquamous carcinoma	28.0	KITLG, PCNA, MUC1, CDKN2A, TP53, SMAD4
14	apnea	27.2	PCNA, BDNF, BCHE, CD79A, MMP9, ENO2
15	sleep apnea	27.1	PCNA, BDNF, CD79A, MMP9, HTR1B, HTR2A
16	laryngeal cancer	27.1	PCNA, NAT1, NAT2, VEGFA, VCAN, BCL2
17	adenoma	26.7	PIK3CA, LRIG3, KITLG, PCSK2, PCNA, PCSK1
18	cervicitis	26.5	PIK3CA, LRIG1, LRIG2, KITLG, PCNA, RBL2
19	laryngeal carcinoma	25.9	PCNA, NAT2, VEGFA, VCAN, BCL2, MUC1
20	prostatitis	19.1	ZNF462, PIK3CA, LRIG1, KITLG, PCNA, RBL2
21	leukemia	17.1	PIK3CA, PICALM, KITLG, RCAN1, RCAN3, PCNA
22	fainting	17.0	BCHE, KCNF1, KCNG2, KCNG4, KCNS3, KCNV2
23	adenocarcinoma	16.5	PIK3CA, KITLG, RCAN1, RCAN2, RCAN3, PCNA
24	hermaphroditism	16.2	RBFOX1, RBFOX2, RBFOX3, MYH1, MYLPF, MYH7B
25	schizophrenia	16.2	PIK3CA, RCAN1, PCNA, VIM, NALCN, NAT1
26	pancreatitis	16.2	PIK3CA, KITLG, PCSK2, PCNA, PCSK1, VIM
27	tuberculosis	15.8	VIM, NAT1, NAT2, VEGFA, VDR, RAPH1
28	thyroiditis	15.7	PIK3CA, PICALM, KITLG, RCAN2, PCSK4, PCSK2
29	hearing loss	15.5	BDNF, KCNQ4, KCNK15, UGT1A6, ATP7A, ATP7B
30	diastrophic dysplasia	15.5	MATR3, SLC26A8, SLC13A4, SLC26A4, SLC26A1, SLC26A6
31	hypertrophic cardiomyopathy	15.4	MYPN, MYH7B, FXN, CD36, ITGA3, ITGA6
32	nicotine dependence	15.2	BDNF, CHRNA6, CHRNA7, CHRNA3, CHRM1, CHRNA4
33	alopecia	15.2	KITLG, VDR, MUC1, T, CD79A, CDKN2A
34	bipolar disorder	15.2	RBFOX1, NALCN, BDNF, BCL2, KCNQ2, CHRFAM7A
35	alzheimer's disease	15.2	PIK3CA, PICALM, KITLG, RCAN1, RCAN2, RCAN3
36	clubfoot	15.1	NAT1, NAT2, MYH1, BCL2, FHL1, HOXA@
37	maturity-onset diabetes of the young	15.0	VDR, BLK, FOXA1, FOXA2, FOXA3, ISL1
38	hepatitis	15.0	PIK3CA, KITLG, PCNA, VIM, NAT1, NAT2
39	neuroblastoma	15.0	PIK3CA, KITLG, PCSK2, PCNA, RBL2, RBL1
40	hepatocellular carcinoma	15.0	PIK3CA, PCNA, RBL2, VIM, NAT1, NAT2
41	galactosemia	14.9	BCHE, MIP, AQP1, AQP2, ALB, ALDH2
42	pediatric cns embryonal cell carcinoma	14.9	UGCG, FYN, CD44, CDH1, INA, FGF8
43	generalized epilepsy with febrile seizures plus	14.9	KCNT1, KCNQ2, KCNQ3, CHRNA7, CHRNA4, ATP1A2
44	mayer-rokitansky-kuster-hauser syndrome	14.9	VDR, ATP7A, ATM, ATP7B, JUP, CD36
45	pachyonychia congenita	14.8	PCSK5, KRT5, KRT81, KRT6A, KRT6B, KRT72
46	congenital heart defect	14.8	CAT, TNNI3, DTNA, DTNB, TBX1, TBX20
47	idiopathic generalized epilepsy	14.8	KCNQ2, KCNQ3, CHRNA7, CHRNA4, ATP1A2, CACNA1G
48	retinitis	14.7	ZNF513, PIK3CA, KITLG, PCNA, RBL2, RBL1
49	monilethrix	14.6	ENSG00000170442, KRT83, KRT81, KRT6A, KRT6B, KRT2
50	esophageal atresia	14.6	GSTM1, GSTP1, GSTT1, FGF10, ENO2, CALCA

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 cefaclor, cefaclor monohydrate, cefadroxil, cefadroxil monohydrate, cefditoren, cefditoren pivoxil, cefprozil, cefuroxime, cefuroxime axetil, cefuroxime sodium, cephalexin, cephalexin hydrochloride, cephalexin monohydrate, guaifenesin

MalaCards organs/tissues related to pharyngitis:

²²

MGI Mouse Phenotypes related to pharyngitis:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	mortality/aging	MP:0010768	22.0	PIK3CA, PICALM, KITLG, PCSK2, PCSK5, PCSK6
2	growth/size phenotype	MP:0005378	20.1	PIK3CA, PICALM, KITLG, RCAN1, RCAN2, PCSK5
3	nervous system phenotype	MP:0003631	19.3	LRIG1, KITLG, PCSK5, PCSK6, RBFOX1, RBFOX2
4	behavior/neurological phenotype	MP:0005386	19.0	PIK3CA, LRIG3, RCAN1, RCAN2, PCSK2, PCSK1
5	normal phenotype	MP:0002873	17.7	LRIG1, RBL2, RBL1, NAT1, VEGFA, VCAN
6	homeostasis/metabolism phenotype	MP:0005376	17.7	PIK3CA, PICALM, KITLG, RCAN1, RCAN2, PCSK2
7	embryogenesis phenotype	MP:0005380	17.3	PIK3CA, PICALM, PCSK6, RBL2, RBL1, VIM
8	cardiovascular system phenotype	MP:0005385	16.5	PIK3CA, KITLG, RCAN1, RCAN2, PCSK2, PCSK5
9	craniofacial phenotype	MP:0005382	16.0	LRIG1, LRIG3, KITLG, PCSK5, PCSK6, RBL1
10	cellular phenotype	MP:0005384	15.9	PIK3CA, PICALM, LRIG1, KITLG, RCAN1, RCAN2
11	endocrine/exocrine gland phenotype	MP:0005379	15.6	LRIG1, RCAN1, PCSK2, PCSK1, RBL2, RBL1
12	immune system phenotype	MP:0005387	15.2	PICALM, RCAN1, RCAN2, PCSK5, PCSK1, RBL1
13	respiratory system phenotype	MP:0005388	14.8	PCSK5, PCSK6, NALCN, LMO7, MYLPF, BMPR1A
14	muscle phenotype	MP:0005369	14.6	PIK3CA, PCSK1, RBL2, RBL1, VIM, VEGFA
15	integument phenotype	MP:0010771	14.5	LRIG1, KITLG, PCSK2, RBL2, RBL1, LMO7
16	hematopoietic system phenotype	MP:0005397	14.2	PICALM, RCAN1, RCAN2, PCNA, PCSK1, RBL1
17	reproductive system phenotype	MP:0005389	14.2	PIK3CA, RCAN1, PCSK4, PCSK2, PCSK1, RBFOX1
18	digestive/alimentary phenotype	MP:0005381	14.1	LRIG1, KITLG, PCSK5, PCSK6, PCSK1, RBL1
19	skeleton phenotype	MP:0005390	13.7	KITLG, RCAN2, PCSK5, RBL2, RBL1, VEGFA
20	hearing/vestibular/ear phenotype	MP:0005377	13.6	LRIG3, KITLG, VDR, BMPR1A, BDNF, BCL2
21	vision/eye phenotype	MP:0005391	13.1	PIK3CA, KITLG, PCSK6, RBL2, RBL1, VIM
22	renal/urinary system phenotype	MP:0005367	13.0	PCSK5, VAV2, VAV3, BCL2, UNCX, CHRM2
23	limbs/digits/tail phenotype	MP:0005371	12.6	LRIG1, KITLG, RCAN2, PCSK5, RBL2, RBL1
24	no phenotypic analysis	MP:0003012	12.4	PCNA, PCSK5, RBL2, RBL1, NALCN, VEGFA
25	liver/biliary system phenotype	MP:0005370	11.8	PICALM, RCAN2, RBL1, VEGFA, CHRM2, CHRM3
26	pigmentation phenotype	MP:0001186	11.4	KITLG, LMO7, BMPR1A, BMPR1B, BCL2, CERS1
27	taste/olfaction phenotype	MP:0005394	11.1	BDNF, FYN, ENO2, GNAT1, GNAT3, TPH2
28	other phenotype	MP:0005395	10.3	ATP7B, CDKN2A, ITGA6, APP, MAP2K4, MAP2K7
29	tumorigenesis	MP:0002006	9.6	PIK3CA, LRIG1, KITLG, RCAN1, RBL2, RBL1

Articles related to pharyngitis:

(show top 50)    (show all 89)

id	Title	Authors	Year	Affiliating Genes
1	Transcription factor snail1 expression and poor survi val in pharyngeal squamous cell carcinoma. (21360437)	Jouppila-MAottAP A.... Kosma V.M.	2011	SNAI1
2	Adhesion molecule periplakin is involved in cellular movement and attachment in pharyngeal squamous cancer cells. (21951621)	Tonoike Y.... Nomura F.	2011	PPL
3	Quantitative analysis of BCL2 mRNA expression in naso pharyngeal carcinoma: an unfavorable and independent prognostic factor. (20514538)	Fendri A.... Scorilas A.	2010	BCL2
4	Role of mesodermal FGF8 and FGF10 overlaps in the dev elopment of the arterial pole of the heart and pharyngeal arch arteries. (20035084)	Watanabe Y.... Buckingham M.E.	2010	FGF10, FGF8
5	Syndromes of the first and second pharyngeal arches: A review. (19610085)	Passos-Bueno M.R.... Fanganiello R.D.	2009	TCOF1
6	Recurrence in oral and pharyngeal cancer is associate d with quantitative MGMT promoter methylation. (19807915)	Taioli E.... Sobol R.W.	2009	MGMT
7	Lack of Rb2/p130 genetic alteration in Malaysian naso pharyngeal carcinoma. (19694314)	Hoe S.L.... Peh S.C.	2009	RBL2
8	Rostral and caudal pharyngeal arches share a common neural crest ground pattern. (19168678)	Minoux M.... Rijli F.M.	2009	HOXA@
9	Great vessel development requires biallelic expressio n of Chd7 and Tbx1 in pharyngeal ectoderm in mice. (19855134)	Randall V.... Scambler P.J.	2009	TBX1
10	Predicting residual neck disease in patients with oro pharyngeal squamous cell carcinoma treated with radiation therapy: utility of p 16 status. (19917926)	Shonka D.C.... Jameson M.J.	2009	CDKN2A
11	Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review. (18496222)	Varela-Lema L.... Ragin C.C.	2008	CYP1A1, GSTM1
12	Pharyngeal carriage and antimicrobial resistance of Haemophilus influenzae in non-type-b-vaccinated healthy children attending day care centers in Turkey. (17308377)	Torun M.M.... Kocazeybek B.	2007	LACTB
13	Sonic hedgehog in the pharyngeal endoderm controls arch pattern via regulation of Fgf8 in head ectoderm. (17187772)	Haworth K.E.... Tucker A.S.	2007	FGF8
14	Myotilin is not the causative gene for vocal cord and pharyngeal weakness with distal myopathy (VCPDM). (16674563)	Garvey S.M.... Hauser M.A.	2006	MYOT
15	Predictive value of SCC-Ag, CYFRA 21-1 and selected acute phase proteins in radiotherapy of pharyngeal and laryngeal cancer. A preliminary report. (15190419)	Kulpa J.... PudeA8ek K.	2004	CRP
16	Distributings and changes of NO and calcitonin gene- related peptide in pharyngeal tissues and plasma in obstructive sleep apnea and hypopnea syndrome (15696922)	Deng A.C.... Chan X.M.	2004	CALCA
17	The regional pattern of retinoic acid synthesis by RALDH2 is essential for the development of posterior pharyngeal arches and the enteric nervous system. (12702665)	Niederreither K.... Dolle P.	2003	ALDH1A2, HOXA1, HOXB1
18	Plasminogen-mediated group A streptococcal adherence to and pericellular invasion of human pharyngeal cells. (14580393)	Pancholi V.... Jin H.	2003	CPA6
19	Tenascin-C expression and its prognostic significance in oral and pharyngeal squamous cell carcinoma. (12926160)	Atula T.... Haglund C.	2003	TNC
20	Expression of E-cadherin, CD44s, and CD44v6 in laryngeal and pharyngeal carcinomas. (14608570)	Rodrigo J.P.... Suarez C.	2003	CDH1
21	Endothelin 1-mediated regulation of pharyngeal bone development in zebrafish. (12588850)	Kimmel C.B.... Crump J.G.	2003	EDN1
22	Bile acid induces cyclo-oxygenase-2 expression in cultured human pharyngeal cells: a possible mechanism of carcinogenesis in the upper aerodigestive tract by laryngopharyngeal reflux. (12782823)	Sung M.W.... Kim K.H.	2003	PTGS2
23	Follicular dendritic cell tumor in the oro-pharyngeal region: report of a case and a review of the literature. (12676264)	Satoh K.... Nakamura S.	2003	FSCN1
24	Decreased serum and pharyngeal antibody levels specific to streptococcal lipoteichoic acid in children with recurrent tonsillitis. (11997155)	Yokoyama Y.... Harabuchi Y.	2002	CD79A
25	Enzyme activities of pharyngeal jaw musculature in th e cichlid Tramitichromis intermedius: implications for sound production in cich lid fishes. (12364404)	Rice A.N.... Lobel P.S.	2002	CS
26	Inducible nitric oxide synthase expression in pharyngeal squamous cell carcinoma: relation to p53 expression, clinicopathological data, and survival. (12160278)	Pukkila M.J.... Kosma V.M.	2002	NOS2
27	Transcription and expression of CD44 variant exons by oro-pharyngeal squamous cell carcinomas. (12239634)	Bloor B.K.... Odell E.W.	2002	CD44
28	Alterations of p53, pRb, cyclin D(1) and cdk4 in human oral and pharyngeal squamous cell carcinomas. (10899671)	Koontongkaew S.... Amornphimoltham P.	2000	CDK4
29	Nuclear expression of the p16CDKN2 gene product during senescence of human pharyngeal epithelial cells. (10733143)	Seki Y.... Tsutsumi K.	2000	CDKN2A
30	Cap 'n' collar B cooperates with a small Maf subunit to specify pharyngeal development and suppress deformed homeotic function in the Drosophila head. (10952900)	Veraksa A.... McGinnis W.	2000	NKRF
31	The relationship between microvessel density, the exp ression of vascular endothelial growth factor (VEGF), and the extension of naso pharyngeal carcinoma. (11129022)	Guang-Wu H.... Kosugi T.	2000	VEGFA
32	Expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases in laryngeal and pharyngeal squamous cell carcinoma: A quantitative analysis. (10793352)	Magary S.P.... Kornberg L.	2000	MMP2, MMP9, MMP1
33	Glutathione S-transferase GSTM1, GSTM3, GSTP1 and GSTT1 genotypes and the risk of smoking-related oral and pharyngeal cancers. (10077151)	Jourenkova-Mironova N.... Hirvonen A.	1999	GSTP1, GSTT1, GSTM3
34	Comparison of cefdinir and penicillin for the treatment of streptococcal pharyngitis. Cefdinir Pharyngitis Study Group. (10890259)	Nemeth M.A.... Tack K.J.	1999	LACTB
35	Role of arylamine N-acetyltransferase 1 and 2 (NAT1 and NAT2) genotypes in susceptibility to oral/pharyngeal and laryngeal cancers. (10780274)	Jourenkova-Mironova N.... Hirvonen A.	1999	NAT1
36	Retinoic acid-induced thymic abnormalities in the mouse are associated with altered pharyngeal morphology, thymocyte maturation defects, and altered expression of Hoxa3 and Pax1. (9894676)	Mulder G.B.... Maggio-Price L.	1998	HOXA3
37	Hoxa1 and Hoxb1 synergize in patterning the hindbrain, cranial nerves and second pharyngeal arch. (9463359)	Gavalas A.... Chambon P.	1998	HOXA1, HOXB1
38	Methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa isolation from pharyngeal swab cultures among the Japanese elderly at admission to a geriatric hospital. (9883040)	Washio M.... Ito Y.	1998	ALB
39	Significance of normal oropharyngeal flora in the de velopment of streptococcal pharyngitis and outcome of penicillin therapy (9720358)	MihajloviA8-Ukropina M.... RonceviA8 N.	1998	LACTB
40	Drug-metabolizing enzymes in pharyngeal mucosa and in oropharyngeal cancer tissue. (9464459)	Ullrich D.... Bock K.W.	1997	CYP1A1, UGT1A6, UGT1A
41	Cell-to-cell signalling between group A streptococci and pharyngeal cells. Role of streptococcal surface dehydrogenase (SDH). (9331703)	Pancholi V.... Fischetti V.A.	1997	SARDH
42	Regulation of the phosphorylation of human pharyngeal cell proteins by group A streptococcal surface dehydrogenase: signal transduction between streptococci and pharyngeal cells. (9362524)	Pancholi V.... Fischetti V.A.	1997	GAPDH, SDHB
43	Beta-lactamase producing bacteria in the pharyngeal flora of patients with acute pharyngitis (7893790)	Romero-Vivas J.... Picazo J.J.	1995	LACTB
44	Cefetamet pivoxil in the treatment of pharyngitis/tonsillitis in children and adults. (7518764)	Guggenbichler J.P.	1994	LACTB
45	Streptococcal adherence to Langerhans cells: a possib le step in the pathogenesis of streptococcal pharyngitis. (8261666)	Reed W.P.... Albright E.	1994	CD1A
46	Argyrophilic nucleolar organizer region counts and proliferating cell nuclear antigen scores are two reliable indicators of survival in pharyngeal carcinoma. (1358893)	Pich A.... Navone R.	1992	PCNA
47	Oral and pharyngeal adenosquamous carcinoma. A report of four cases with immunohistochemical studies. (1716111)	Martinez-Madrigal F.... Micheau C.	1991	KITLG
48	Treatment of beta-hemolytic streptococcal pharyngitis with cefaclor or penicillin. Efficacy and interaction with beta-lactamase-prod ucing organisms in the pharynx. (1990041)	Reed B.D.... Zazove P.	1991	LACTB
49	Monocytes and polymorphonuclear neutrophils of patients with streptococcal pharyngitis express increased numbers of type I IgG Fc receptors. (2147695)	Guyre P.M.... Fanger M.W.	1990	FCGR1A
50	Clindamycin in the treatment of an outbreak of streptococcal pharyngitis in a kibbutz due to beta-lactamase producing organisms. (2380767)	Raz R.... Flatau E.	1990	LACTB

Genes related to pharyngitis according to GeneCards:

(show top 50)    (show all 561)

id	Symbol	Description	Score	GeneCards Section Context
1	MATR3	matrin 3	11.1	Aliases & Descriptions, Publications, Summaries
2	DGCR	DiGeorge syndrome chromosome region	11.0	Summaries
3	GSC2	goosecoid homeobox 2	11.0	Summaries
4	NKX2-6	NK2 homeobox 6	11.0	Summaries, Pathways & Interactions, Functions
5	ADH5	alcohol dehydrogenase 5 (class III), chi polypeptide	11.0	Summaries, Publications
6	POF1B	premature ovarian failure, 1B	11.0	Summaries
7	LACTB	lactamase, beta	11.0	Publications
8	CD1A	CD1a molecule	10.9	Publications
9	GPER	G protein-coupled estrogen receptor 1	10.9
10	B4GALNT2	beta-1,4-N-acetyl-galactosaminyl transferase 2	10.9
11	FCGR1A	Fc fragment of IgG, high affinity Ia, receptor (CD64)	10.9	Publications
12	GSTM3	glutathione S-transferase mu 3 (brain)	10.9	Publications
13	ADH1C	alcohol dehydrogenase 1C (class I), gamma polypeptide	10.9	Publications
14	RHOD	ras homolog family member D	10.9
15	GSTM1	glutathione S-transferase mu 1	10.9	Publications
16	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	10.9	Publications
17	CDKN2A	cyclin-dependent kinase inhibitor 2A	10.9	Publications
18	TNF	tumor necrosis factor	10.9	Publications
19	ENSG00000170442		10.9	Orthologs
20	MYLPF	myosin light chain, phosphorylatable, fast skeletal muscle	10.9	Orthologs
21	HOXA@	homeobox A cluster	10.9	Publications
22	ENSG00000250424		10.9	Orthologs
23	PDPK2	3-phosphoinositide dependent protein kinase-1 pseudogene	10.9	Orthologs
24	KCNS2	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	10.9	Orthologs
25	KCNF1	potassium voltage-gated channel, subfamily F, member 1	10.9	Orthologs
26	MXD3	MAX dimerization protein 3	10.9	Orthologs
27	KCNV1	potassium channel, subfamily V, member 1	10.9	Orthologs
28	TBX2	T-box 2	10.9	Orthologs
29	MYL7	myosin, light chain 7, regulatory	10.9	Orthologs
30	MYL10	myosin, light chain 10, regulatory	10.9	Orthologs
31	TBR1	T-box, brain, 1	10.9	Orthologs
32	PRPH	peripherin	10.9	Orthologs
33	KRT82	keratin 82	10.9	Orthologs
34	KRT79	keratin 79	10.9	Orthologs
35	KRT83	keratin 83	10.9	Orthologs
36	KRT85	keratin 85	10.9	Orthologs
37	KRT76	keratin 76	10.9	Orthologs
38	KRT73	keratin 73	10.9	Orthologs
39	KRT81	keratin 81	10.9	Orthologs
40	CHRFAM7A	CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion	10.9	Orthologs
41	KRT74	keratin 74	10.9	Orthologs
42	KRT78	keratin 78	10.9	Orthologs
43	KRT77	keratin 77	10.9	Orthologs
44	DGCR6L	DiGeorge syndrome critical region gene 6-like	10.9	Functions
45	KRT72	keratin 72	10.9	Orthologs
46	TBX3	T-box 3	10.9	Orthologs
47	KCNS1	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1	10.9	Orthologs
48	KRT84	keratin 84	10.9	Orthologs
49	GLRA4	glycine receptor, alpha 4	10.9	Orthologs
50	KRT2	keratin 2	10.9	Orthologs

Pathways related to pharyngitis according to GeneDecks:

(show top 50)    (show all 172)

id	Pathway	Score	Top Affiliating Genes
1	Neuroactive ligand-receptor interaction20	13.4	CHRM2, CHRNA6, CHRNA7, CHRM5, CHRNA3, CHRM1
2	cAMP Pathway36	13.3	KITLG, BDNF, KCNK9, KCNT1, KCNV2, KCNK15
3	Actin Nucleation by ARP-WASP Complex36	13.2	MYH1, MYH7B, LIFR, ITGA3, ITGA6, ITGA7
4	Cellular Effects of Sildenafil36	12.9	MYH1, MYH7B, KCNK9, KCNT1, KCNV2, KCNK15
5	Tight junction20	12.8	MYH1, MYLPF, MYH7B, MYL10, RAB3B, YES1
6	Inhibitory action of Lipoxins on neutrophil migration41	12.8	MYH1, MYLPF, PAK1, GNAI1, GNAI2, GNAI3
7	Intracellular Calcium Signaling36	12.7	KITLG, LIFR, BDNF, CHRNA6, CHRNA7, CHRNA3
8	Transendothelial Migration of Leukocytes36	12.7	VAV1, VAV2, VAV3, MYH1, MYH7B, PAK1
9	Immune response CCR3 signaling in eosinophils10	12.5	VAV2, MYH1, MYLPF, PAK1, ITPR1, ITPR2
10	Immune response _CCR3 signaling in eosinophils41	12.5	VAV2, MYH1, MYLPF, PAK1, ITPR1, ITPR2
11	RhoA Pathway36	12.5	MYH1, MYH7B, ITGA3, ITGA6, ITGA7, GNA11
12	Factors Promoting Cardiogenesis in Vertebrates36	12.4	MYH7B, BMPR1A, BMPR1B, GNA11, GNAI1, GNAI2
13	Regulation of actin cytoskeleton20	12.4	VAV1, VAV2, VAV3, MYLPF, MYL10, PAK1
14	Cell adhesion Tight junctions10	12.4	MYH1, MYLPF, MPDZ, SNAI1, ACTB, ACTG1
15	Cell adhesion_Tight junctions41	12.4	MYH1, MYLPF, MPDZ, SNAI1, ACTB, ACTG1
16	Epithelial Adherens Junctions36	12.4	KITLG, LMO7, VAV2, MYH1, MYH7B, YES1
17	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases10	12.4	MYH1, MYLPF, PAK1, FSCN1, ACTB, ACTG1
18	Cytoskeleton remodeling_Regulation of actin cytoskeleton by Rho GTPases41	12.4	MYH1, MYLPF, PAK1, FSCN1, ACTB, ACTG1
19	Cell adhesion_Integrin-mediated cell adhesion and migration41	12.3	MYH1, MYLPF, PAK1, ITGA3, ITGA7, ACTB
20	Cell adhesion Integrin-mediated cell adhesion and migration10	12.3	MYH1, MYLPF, PAK1, ITGA3, ITGA7, ACTG1
21	RhoGDI Pathway36	12.3	MYH1, MYH7B, PAK1, PAK4, PAK7, PAK2
22	GnRH Signaling36	12.3	PAK1, PAK4, PAK7, PAK2, PAK3, PAK6
23	PKA Signaling36	12.3	KCNK9, KCNT1, KCNV2, KCNK15, KCNK3, KCNV1
24	Human Embryonic Stem Cell Pluripotency36	12.2	BMPR1A, BMPR1B, GNA11, GNAI1, GNAI2, GNAI3
25	Fc-GammaR-Mediated Phagocytosis in Macrophages36	12.2	VAV1, VAV2, VAV3, MYH1, MYH7B, FCGR1A
26	Development MAG-dependent inhibition of neurite outgrowth10	12.1	MYH1, MYLPF, BDNF, ACTB, ACTG1, MYH13
27	Development_MAG-dependent inhibition of neurite outgrowth41	12.1	MYH1, MYLPF, BDNF, ACTB, ACTG1, MYH13
28	Amine ligand-binding receptors38	12.1	CHRM2, CHRM3, CHRM4, HTR1A, HTR1B, HTR1D
29	Actin Nucleation and Branching36	12.0	LIFR, PAK1, PAK4, PAK7, PAK2, PAK3
30	eNOS Signaling36	12.0	KITLG, LIFR, BDNF, CHRNA6, CHRNA7, CHRNA3
31	Cytoskeletal Signaling3	12.0	VIM, VAV1, VAV2, VAV3, PAK1, PAK4
32	Voltage gated Potassium channels38	11.9	KCNF1, KCNG2, KCNG4, KCNQ4, KCNS3, KCNV2
33	ILK Signaling36	11.9	KITLG, VIM, MYH1, MYH7B, LIFR, BDNF
34	Ion transport by P-type ATPases38	11.8	ATP8A1, ATP1A2, ATP4A, ATP7A, ATP1A3, ATP8B2
35	PAK Pathway36	11.8	KITLG, MYH1, MYH7B, PAK1, PAK4, PAK7
36	Cytoskeleton remodeling Keratin filaments10	11.8	VIM, PPL, KRT8, KRT4, KRT7, KRT5
37	Calcium signaling pathway20	11.7	CHRM2, CHRNA7, CHRM5, CHRM1, CHRM3, ITPR1
38	Actin-Based Motility by Rho Family GTPases36	11.7	PAK1, PAK4, PAK7, PAK2, PAK3, PAK6
39	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics34	11.6	HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A
40	Cytoskeleton remodeling_Keratin filaments41	11.6	VIM, PPL, KRT8, KRT4, KRT7, KRT5
41	Gastric acid secretion20	11.4	CHRM3, ATP1A2, ATP4A, ATP1A3, ATP1A4, ATP1A1
42	MAPK Signaling36	11.4	KITLG, LIFR, PAK1, PAK4, PAK7, PAK2
43	Cholinergic synapse20	11.3	PIK3CA, BCL2, KCNQ4, KCNQ2, KCNQ3, KCNQ5
44	TCR Signaling36	11.1	VAV1, VAV2, VAV3, PAK1, PAK4, PAK7
45	IP3 Pathway36	11.1	KITLG, VAV1, VAV2, VAV3, BDNF, FYN
46	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins10	11.0	VAV1, VAV2, PAK1, MAP2K7, GNA11, GNAI1
47	G-protein signaling_Regulation of p38 and JNK signaling mediated by G-proteins41	10.9	VAV1, VAV2, PAK1, MAP2K4, MAP2K7, GNA11
48	ABC transporters20	10.8	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3
49	Focal adhesion20	10.7	PIK3CA, VEGFA, VAV1, VAV2, VAV3, MYLPF
50	Molecular Mechanisms of Cancer36	10.3	KITLG, RBL1, BMPR1A, BMPR1B, BDNF, BCL2

Compounds related to pharyngitis according to GeneDecks:

(show top 50)    (show all 270)

id	Compound	Score	Top Affiliating Genes
1	calcium32 9 18 9	17.4	KITLG, RCAN2, PCSK2, PCSK6, PCSK1, RBL1
2	tyrosine32	13.1	PIK3CA, LRIG1, KITLG, RCAN1, PCSK2, RBL2
3	adp32 18	13.8	PIK3CA, BMPR1A, BMPR1B, BLK, PAK1, PAK4
4	lipid32	12.4	PIK3CA, KITLG, PCSK2, PCSK1, VIM, VAV1
5	serine32	12.1	PIK3CA, KITLG, RCAN1, PCSK4, PCSK2, PCSK5
6	glucose32	12.1	PCSK2, PCSK1, VCAN, PAK1, UGDH, FXN
7	potassium32 9 18 9	15.1	PIK3CA, KITLG, BDNF, BCHE, KCNK9, KCNQ4
8	threonine32	12.0	RCAN1, RBL2, BMPR1A, BMPR1B, PAK4, PAK3
9	atp32	12.0	PIK3CA, RBL2, RBL1, MYH1, PAK1, PAK2
10	nitric oxide32 9 18 9	14.9	KITLG, NAT1, NAT2, CHRM2, CHRM1, MUC1
11	quetiapine32 9 18 9	14.9	BDNF, CHRM2, CHRM5, CHRM1, CHRM3, CHRM4
12	progesterone32 42 9 18 9	15.8	PIK3CA, PCNA, PCSK1, LIFR, BCL2, FURIN
13	aripiprazole32 34 9 18 9	15.7	CHRM2, CHRM5, CHRM1, CHRM3, CHRM4, HTR1A
14	oligonucleotide32	11.7	PCNA, RBL1, VIM, NAT1, NAT2, VCAN
15	ziprasidone32 9 9	13.7	CHRM2, CHRM5, CHRM1, CHRM3, CHRM4, HTR1A
16	retinoic acid32 42 18	13.5	PIK3CA, KITLG, PCSK2, PCNA, VIM, VDR
17	mastoparan x42 32	12.5	GNA11, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ
18	sodium32 18	12.5	PIK3CA, NALCN, BDNF, KCNT1, KCNQ2, KCNQ3
19	olanzapine32 34 9 18 9	15.4	BDNF, CHRM2, CHRM5, CHRM1, CHRM3, CHRM4
20	estrogen32	11.4	PCNA, PCSK1, NAT1, NAT2, VDR, LIFR
21	alanine32	11.3	KITLG, PCNA, RBL2, RBL1, VDR, LIFR
22	aspartate32	11.3	PCNA, VIM, VDR, BDNF, SDHB, CHRNA7
23	oxygen32 18	12.3	KITLG, PAK2, BDNF, BCHE, BCL2, SDHB
24	arginine32	11.3	PIK3CA, PCSK2, PCNA, PCSK6, PCSK1, RBL1
25	5-hydroxytryptamine32	11.3	VIM, PAK1, CHRM2, CHRNA7, CHRM1, UGT1A6
26	clozapine32 34 9 9	14.2	BDNF, CHRM2, CHRNA7, CHRM5, CHRM1, CHRM3
27	Propiomazine9 9	12.2	CHRM2, CHRM5, CHRM1, CHRM3, CHRM4, HTR2A
28	cysteine32	11.1	PCNA, NAT1, NAT2, VDR, PAK2, SDHB
29	h2o232	11.0	KITLG, RCAN1, NAT1, BDNF, BCHE, SDHB
30	doxepin32 34 9 9	14.0	CHRM2, CHRM5, CHRM1, CHRM3, CHRM4, HTR1A
31	glutamate32	11.0	PIK3CA, PCNA, VIM, VDR, PAK1, BCHE
32	dopamine32 9 18 9	14.0	PIK3CA, BDNF, SDHB, CHRNA7, CHRM5, CHRM1
33	acetylcholine32 9 18 9	13.9	VIM, PAK1, BDNF, BCHE, UNC13B, KCNQ2
34	retinoid32	10.8	VIM, VDR, BCL2, CDK4, CDH1, ITGA3
35	phosphoinositide32	10.4	PIK3CA, VIM, VAV1, PAK1, PAK2, BDNF
36	testosterone32 9 18 9	13.3	PIK3CA, KITLG, PCNA, VIM, VDR, VAV3
37	creatinine32	10.3	KITLG, PCNA, VDR, PABPN1, BDNF, BCHE
38	norepinephrine32 9 18 9	13.2	KITLG, BDNF, BCHE, SDHB, CHRM2, CHRM3
39	vitamin a32 9 18 9	13.1	VIM, NAT2, VDR, MMP1, MMP2, MMP9
40	formaldehyde32 18	11.0	PCNA, VIM, MUC1, SARDH, CD79A, CD44
41	egcg32	9.9	UGT1A, APP, HSPG2, CAT, TIMP1
42	phosphatidylinositol32	9.7	PIK3CA, KITLG, RBL1, VAV1, VAV2, VAV3
43	paraffin32	9.5	KITLG, PCNA, VIM, VEGFA, BCL2, MUC1
44	lactate32	9.2	PIK3CA, KITLG, PCNA, VIM, BDNF, BCHE
45	herbimycin a32 42	10.1	KITLG, VAV1, LCK, FYN, CD36, CDK4
46	dexamethasone32 42 34 9 9	12.7	PIK3CA, KITLG, PCSK2, PCNA, VIM, NAT2
47	paclitaxel32 34 9 9	11.6	PIK3CA, KITLG, PCNA, VIM, NAT1, VEGFA
48	genistein32 9 18 9	11.5	PIK3CA, KITLG, PCNA, VIM, VEGFA, VDR
49	curcumin32	7.8	NAT1, VEGFA, PAK2, BCL2, UGT1A, CDK4
50	vegf32	7.7	PIK3CA, KITLG, RCAN1, PCNA, VIM, VEGFA

Cellular components related to pharyngitis according to GeneDecks:

(show all 23)

id	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:005886	21.1	CHRNA5, SLC26A9, SLC26A3, SLC11A1, SLC15A2, SLC11A2
2	nucleus	GO:005634	20.2	NOS2, PLCB4, SMAD4, SNAP23, SNAI1, NR1I3
3	cytoplasm	GO:005737	15.4	SMAD4, SNAP25, SNAI1, NR1I3, NR1H3, NR1H2
4	integral to plasma membrane	GO:005887	14.9	HLA-DRB1, TNF, ODZ1, PLXNA2, PLAUR, NOTCH2
5	keratin filament	GO:045095	14.0	KRT2, KRT76, KRT84, KRT5, KRT7, KRT77
6	cytosol	GO:005829	13.9	RHOD, RHOBTB2, RHOBTB1, PDPK1, RHOH, RHOU
7	Golgi apparatus	GO:005794	12.2	NUCB1, HCK, ACHE, ABCA1, WDR44, KRT2
8	intermediate filament	GO:005882	12.2	KRT6C, KRT2, GFAP, DSP, DES, PRPH
9	membrane	GO:016020	12.2	SLC15A1, SLC26A3, SLC18A1, SLC35B2, SORD, NUCB1
10	voltage-gated potassium channel complex	GO:008076	12.1	KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, SNAP25
11	postsynaptic membrane	GO:045211	12.0	APBB1, FAIM2, CADPS2, GLRA1, GLRA2, GLRA3
12	neuronal cell body	GO:043025	11.9	CALCA, TBX21, SNAP25, ACVRL1, SYT5, PRPH
13	myosin filament	GO:032982	11.9	MYH8, MYH7, MYH6, MYH4, MYH3, MYH2
14	myofibril	GO:030016	11.8	MYL2, MYH8, MYH6, MYH4, MYH3, MYH2
15	cell junction	GO:030054	11.8	CHRNB3, CHRNA5, CHRNA2, SYT5, SYT2, SYT1
16	Z disc	GO:030018	11.5	MYH7, MYH6, OBSL1, OBSCN, DES, TTN
17	perinuclear region of cytoplasm	GO:048471	11.2	SYNJ2, DNM3, ACHE, NDOR1, WDR44, SYT5
18	muscle myosin complex	GO:005859	11.1	MYH8, MYH7, MYH6, MYH4, MYH2, MYH13
19	axon terminus	GO:043679	11.0	HAP1, SYNJ2, CHRM4, CHRM3, CHRM1, CHRM2
20	acetylcholine-gated channel complex	GO:005892	10.6	CHRNB3, CHRNA5, CHRNA2, CHRNA4, CHRNA1, CHRNA3
21	presynaptic membrane	GO:042734	10.5	SYP, ERC2, ERC1, CADPS2, APBB1, GRM3
22	synapse	GO:045202	10.1	ACHE, RPS6KB1, SNAP23, SNAP25, DTNB, DTNA
23	cell surface	GO:009986	9.8	PLAUR, NOTCH2, RPS6KB1, ACVR1B, ACVRL1, SLC11A2

Biological processes related to pharyngitis according to GeneDecks:

(show all 49)

id	Name	GO ID	Score	Top Affiliating Genes
1	transmembrane transport	GO:055085	14.9	ATP1A1, GLRB, ABCA3, ABCA4, ABCA7, ABCA8
2	synaptic transmission	GO:007268	14.5	KCNF1, KCNV1, CHRNA6, CHRNA7, CHRNA3, CHRNA4
3	positive regulation of transcription from RNA polymerase II promoter	GO:045944	14.2	HES1, ACVRL1, ACVR1, ACVR1B, EOMES, NFIX
4	positive regulation of transcription, DNA-dependent	GO:045893	12.9	ACVRL1, ACVR1, EOMES, SMAD4, SNAI1, NR1I2
5	ion transport	GO:006811	12.7	SLC15A2, SLC26A3, SLC26A9, SLC15A1, SLC1A2, SLC26A7
6	G-protein coupled receptor signaling pathway	GO:007186	12.6	GNAI2, GNAT2, GNAZ, GNB5, EDN1, ABCA1
7	signal transduction	GO:007165	12.6	ODZ4, NR1H4, NR1I2, NR1I3, PLAUR, RPS6KB1
8	negative regulation of transcription from RNA polymerase II promoter	GO:000122	12.4	NFIB, SMAD4, SNAI1, NR1H4, NR1H3, DLX2
9	positive regulation of cell proliferation	GO:008284	12.4	HCK, EDN1, KRT6A, TBX3, TBX2, HES1
10	ion transmembrane transport	GO:034220	12.3	ATP10A, ATP7B, ATP10D, GLRA1, GLRA2, GLRA3
11	transport	GO:006810	12.2	ABCA3, ABCA4, ABCA6, ABCA8, ABCA9, SLC15A2
12	muscle contraction	GO:006936	12.2	MYH13, MYH2, MYH4, MYH6, MYH7, MYH8
13	cell proliferation	GO:008283	12.2	ERG, TP53, TBX1, TBX20, DLX5, SMAD4
14	potassium ion transport	GO:006813	12.2	KCNQ3, KCNS1, KCNV1, ATP1A2, ATP1A4, AQP1
15	muscle filament sliding	GO:030049	12.1	MYH4, MYH6, MYH7, MYH8, MYL2, MYH3
16	pharyngeal system development	GO:060037	12.1	EYA1, PTCH1, TBX1, PLXNA2, ACVR1, HES1
17	cytoskeleton organization	GO:007010	11.9	KRT76, KRT3, KRT6C, DES, OBSL1, KRT7
18	negative regulation of transcription, DNA-dependent	GO:045892	11.8	NR1I2, SMAD4, WWP1, WWP2, HES1, NKRF
19	inner ear morphogenesis	GO:042472	11.7	KCNQ4, TBX1, DLX5, DLX6, OTX1, OTX2
20	ATP biosynthetic process	GO:006754	11.6	ATP7B, ATP12A, ATP1A1, ATP1A4, ATP5B, ATP1A3
21	thyroid gland development	GO:030878	11.6	HHEX, SIX1, NKX2-5, TBX1, HOXA3, FGF8
22	outflow tract septum morphogenesis	GO:003148	11.5	NKX2-5, TBX20, TBX2, TBX1, FGF8, ISL1
23	embryonic cranial skeleton morphogenesis	GO:048701	11.5	SIX4, SIX2, SIX1, TGFBR1, DLX2, TBX15
24	nervous system development	GO:007399	11.5	DLX5, DLX6, ODZ1, CRIM1, NOTCH2, ACHE
25	sulfate transport	GO:008272	11.5	SLC13A4, SLC26A4, SLC26A1, SLC26A7, SLC26A2, SLC26A8
26	regulation of membrane potential	GO:042391	11.4	SLC26A5, WWP2, GLRB, GLRA1, CACNA1H, CACNA1G
27	serotonin receptor signaling pathway	GO:007210	11.3	HTR5A, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C
28	thymus development	GO:048538	11.3	GATA3, SIX4, SIX1, TGFBR1, HES1, TBX1
29	organ morphogenesis	GO:009887	11.3	NOTCH2, DGCR6, SOX3, SLIT3, SIX6, TBX3
30	outflow tract morphogenesis	GO:003151	11.2	HES1, TBX3, TBX2, TBX1, EYA1, ISL1
31	protein phosphorylation	GO:006468	11.1	ERG, RPS6KB1, PDPK1, ACVR1C, ACVR1B, ACVR1
32	BMP signaling pathway	GO:030509	11.1	MYH6, NKX2-5, ACVRL1, ACVR1, SMAD4, FGF8
33	pituitary gland development	GO:021983	11.0	SOX3, TBX19, ALDH1A2, FGF10, CDH1, BMPR1A
34	regulation of insulin secretion	GO:050796	11.0	KCNS3, CHRM3, ITPR1, ITPR2, ITPR3, TNF
35	aorta morphogenesis	GO:035909	11.0	SIX1, TBX2, TBX1, EYA1, FGF8
36	negative regulation of cell proliferation	GO:008285	10.9	NOTCH2, ACVR1C, ACVRL1, CSK, SLIT3, SLIT2
37	cochlea development	GO:090102	10.8	HES1, HOXA1, CDH1, KCNK3, KCNK9
38	heart development	GO:007507	10.8	TBX5, CRIP1, EDN1, TGFBR1, NKX3-1, ECE1
39	extracellular matrix organization	GO:030198	10.8	TNF, PLOD2, PLOD3, PLOD1, GFAP, TIMP1
40	sarcomere organization	GO:045214	10.8	MYH6, NKX2-5, OBSCN, TTN, ACTG1, MYPN
41	T cell costimulation	GO:031295	10.8	LYN, CSK, PDPK1, HLA-DRB1, FYN, YES1
42	response to drug	GO:042493	10.8	PTGS2, TNF, GNAO1, HTR2C, HTR2B, HTR2A
43	in utero embryonic development	GO:001701	10.4	HES1, TGFBR1, SLIT2, HHEX, GATA3, MYH6
44	negative regulation of cell growth	GO:030308	10.4	ACVR1B, ACVRL1, SLIT3, SLIT2, MYL2, SMAD4
45	cell growth	GO:016049	10.1	ADRA1B, ADRA1A, EDN1, NOTCH2, MMP9, XRN2
46	negative regulation of apoptotic process	GO:043066	9.9	PLAUR, SNAI1, TNF, TP53, CAT, RPS6KB1
47	platelet activation	GO:030168	9.8	GNAI1, GNAI2, GNAI3, GNAQ, PDPK1, TTN
48	blood coagulation	GO:007596	9.4	ACTB, PDPK1, NOS2, PLAUR, TP53, GNAQ
49	response to hypoxia	GO:001666	9.3	SMAD4, CRP, PLOD2, PLOD1, NOS2, EDN1

Molecular functions related to pharyngitis according to GeneDecks:

(show all 39)

id	Name	GO ID	Score	Top Affiliating Genes
1	sequence-specific DNA binding transcription factor activity	GO:003700	17.4	TBX15, DLX2, DLX3, DLX4, DLX5, DLX6
2	protein binding	GO:005515	16.9	SLC15A2, EMX2, HAP1, HHEX, GAPDH, GATA3
3	ATP binding	GO:005524	14.6	ATP8B2, CDK4, FGR, MATK, MAP2K4, MAP2K7
4	DNA binding	GO:003677	14.5	NR1H3, NR1I3, SMAD4, NFIA, NFIB, NFIC
5	sequence-specific DNA binding	GO:043565	14.3	NKX2-3, TCF3, HES1, EOMES, SMAD4, SNAI1
6	structural molecule activity	GO:005198	13.5	KRT85, KRT80, KRT79, KRT74, KRT3, KRT72
7	actin binding	GO:003779	13.0	TNNI2, TNNI3, POF1B, MYH13, MYH15, MYH2
8	structural constituent of cytoskeleton	GO:005200	12.1	ACTB, ACTG1, GFAP, DSP, DES, NEFM
9	metal ion binding	GO:046872	12.1	CRP, PFKL, PFKM, PFKP, PTGS2, CAT
10	transcription regulatory region sequence-specific DNA binding	GO:000976	12.0	DLX6, NKX3-1, EMX2, GATA3, DLX5, DLX4
11	voltage-gated potassium channel activity	GO:005249	11.9	SNAP25, KCNV1, KCNS2, KCNQ3, KCNQ2, KCNG3
12	transcription regulatory region DNA binding	GO:044212	11.9	TCF12, TCF3, NKX2-5, NKX3-1, SIX1, WNT5A
13	structural constituent of muscle	GO:008307	11.9	MYL2, MYH8, MYH7, MYH6, MYH4, MYH2
14	ATPase activity	GO:016887	11.7	ABCA6, ABCA7, ABCA9, RUVBL1, MYH6, MYH7
15	secondary active sulfate transmembrane transporter activity	GO:008271	11.6	SLC26A5, SLC26A2, SLC26A9, SLC26A3, SLC26A6, SLC26A1
16	potassium channel activity	GO:005267	11.6	AQP1, KCNQ3, KCNQ2, KCNF1, KCNK9, KCNQ4
17	serotonin receptor activity	GO:004993	11.5	HTR7, HTR5A, HTR2C, HTR2B, HTR2A, HTR1F
18	protein serine/threonine kinase activity	GO:004674	11.5	ACVR1B, PDPK2, PDPK1, RPS6KB2, ACVR1, ACVRL1
19	sulfate transmembrane transporter activity	GO:015116	11.5	SLC26A2, SLC26A7, SLC26A10, SLC26A1, SLC26A4, SLC26A8
20	microfilament motor activity	GO:000146	11.5	MYL7, MYH7, MYH6, MYH4, MYH3, MYH2
21	acetylcholine-activated cation-selective channel activity	GO:004889	11.4	CHRNB3, CHRNA5, CHRNA2, CHRNA4, CHRNA3, CHRNA7
22	serotonin binding	GO:051378	11.3	HTR2C, HTR2B, HTR2A, HTR1F, HTR1E, HTR1D
23	acetylcholine binding	GO:042166	11.3	CHRNB3, CHRNA5, ACHE, CHRNA4, CHRM3, CHRNA3
24	G-protein coupled acetylcholine receptor activity	GO:016907	11.3	CHRM4, CHRM3, CHRM1, CHRM5, CHRM2
25	acetylcholine receptor activity	GO:015464	11.2	CHRNA5, CHRNA2, CHRNA4, CHRNA3, CHRNA7, CHRNA6
26	protein heterodimerization activity	GO:046982	11.2	TCF12, TCF3, TCF4, SYT5, NPAS4, NKX2-5
27	drug binding	GO:008144	11.2	SLC18A2, NR1I2, ALB, HTR2C, HTR2B, HTR2A
28	protein tyrosine kinase activity	GO:004713	11.1	HCK, TTN, OBSCN, CSK, LYN, MAP2K7
29	non-membrane spanning protein tyrosine kinase activity	GO:004715	11.1	LYN, CSK, HCK, MATK, FGR, FRK
30	transmembrane receptor protein serine/threonine kinase activity	GO:004675	11.1	BMPR1A, BMPR1B, ACVR1B, ACVR1, ACVRL1, TGFBR1
31	extracellular-glycine-gated chloride channel activity	GO:016934	11.0	GLRA2, GLRA3, GLRB, GLRA1
32	transmitter-gated ion channel activity	GO:022824	11.0	GLRA1, GLRA2, GLRA3, GLRA4
33	phospholipid-translocating ATPase activity	GO:004012	11.0	ABCA4, ATP10D, ATP8A2, ATP8B4, ATP10A, ATP8B2
34	activin receptor activity, type I	GO:016361	10.9	ACVRL1, ACVR1C, ACVR1B, ACVR1
35	phosphatidylinositol phospholipase C activity	GO:004435	10.8	HTR2C, HTR2B, HTR2A, CHRM3, CHRM1, CHRM5
36	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	GO:015662	10.8	ATP10D, ATP8A2, ATP8B4, ATP10A, ATP8B2, ATP10B
37	transcription factor binding	GO:008134	10.7	NFIA, WWP2, HES1, TCF3, NKX2-5, NKX3-1
38	protein homodimerization activity	GO:042803	10.7	ACVR1, ACHE, NOS2, PLOD1, CRP, CR2
39	transforming growth factor beta receptor activity, type I	GO:005025	10.6	BMPR1B, ACVR1, ACVRL1, TGFBR1