MCID: PHR003
MIFTS: 62

Pharyngitis malady

Respiratory diseases, Oral diseases categories

Summaries for Pharyngitis

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Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An upper respiratory tract disease involving inflammation of the throat or pharynx resulting from bacterial, viral, fungal infections or irritants like pollutants or chemical substances and smoking. the infection is often referred to as "sore throat". the symptoms include pain during swallowing, enlarged tonsils coated with a white discharge, runny nose, cough and slight fever.

MalaCards: Pharyngitis, also known as chronic pharyngitis, is related to digeorge syndrome and velocardiofacial syndrome. An important gene associated with Pharyngitis is MATR3 (matrin 3), and among its related pathways are Drug metabolism - cytochrome P450 and Neural Crest Differentiation. The drugs guaifenesin and cefditoren and the compounds vitamin a and hydrochloric acid have been mentioned in the context of this disorder. Affiliated tissues include tonsil, testes and heart, and related mouse phenotypes are normal and craniofacial.

Wikipedia:63 The word pharyngitis /færɨnˈdʒaɪtɨs/ comes from the Greek word pharynx pharanx meaning throat and... more...

Aliases & Classifications for Pharyngitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases, Oral diseases


Aliases & Descriptions:

pharyngitis 8 10 44 60
chronic pharyngitis 8 60
acute pharyngitis 8 60
chronic pharyngitis and nasopharyngitis nos 8
chronic pharyngitis and nasopharyngitis 8
chronic pharyn/nasopharyngitis 8
chronic pharyngitis nos 8
persistent sore throat 8
sore throat - chronic 8
acute sore throat nos 8
chronic sore throat 8
pharyngitis - acute 8
disorder of pharynx 8
pharyngeal disorder 8
pharyngeal diseases 60
acute sore throat 8
inflamed throat 8


Related Diseases for Pharyngitis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Pharyngitis:



Diseases related to pharyngitis

Clinical Features for Pharyngitis

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Drugs & Therapeutics for Pharyngitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pharyngitis

Drug clinical trials:

Search ClinicalTrials for Pharyngitis

Search NIH Clinical Center for Pharyngitis

Search CenterWatch for Pharyngitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Pharyngitis

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Anatomical Context for Pharyngitis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Pharyngitis:

32
Tonsil, Testes, Heart, Bone, Endothelial, Cortex, Colon, Monocytes, Salivary gland, Thyroid, Myeloid, Lung, Lymph node, Pituitary

Animal Models for Pharyngitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pharyngitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000287310.7NKX2-6, POF1B, HOXB1, HOXA1, FGF8, GSC2
2MP:000538210.6FGF8, HOXA1, HOXB1, NKX2-3, TNF, SOX3
3MP:000538010.4SOX3, TNF, NKX2-6, HOXB1, HOXA1, FGF8

Publications for Pharyngitis

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50PubMed
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Articles related to Pharyngitis:

(show top 50)    (show all 808)
idTitleAuthorsYear
1
A retrospective comparative study of 2-drug oral and intramuscular cephalosporin treatment regimens for pharyngeal gonorrhea. (23408680)
2013
2
Comparison among nasopharyngeal swab, nasal wash, and oropharyngeal swab for respiratory virus detection in adults with acute pharyngitis. (23786598)
2013
3
Multilevel treatment of moderate and severe obstructive sleep apnea with bone-anchored pharyngeal suspension sutures. (23975494)
2013
4
Cervical osteomyelitis after carbon dioxide laser excision of recurrent carcinoma of the posterior pharyngeal wall. (23697326)
2013
5
Cost-effectiveness of pharmacist-provided treatment of adult pharyngitis. (22554040)
2012
6
The influence of laterality of pharyngeal bolus passage on Dysphagia in hemiplegic stroke patients. (23185735)
2012
7
Lateral pharyngeal wall motion analysis using ultrasonography in stroke patients with dysphagia. (23062372)
2012
8
Adolescent pharyngitis: a review of bacterial causes. (21646249)
2011
9
Clinicomicrobiological profile of children with acute pharyngitis with special reference to streptococcol grouping. (23469573)
2011
10
Impact of rapid antigen detection testing on antibiotic prescription in acute pharyngitis in adults. FARINGOCAT STUDY: a multicentric randomized controlled trial. (20331895)
2010
11
Group A streptococcal pharyngitis and immune-mediated complications: from diagnosis to management. (20109044)
2010
12
Pharyngeal perforation masquerading as esophageal atresia. (19944236)
2009
13
Syndromes of the first and second pharyngeal arches: A review. (19610085)
2009
14
The clinical pattern of group C streptococcal pharyngitis in children. (19688241)
2009
15
Bias in the evaluation of pharyngitis and antibiotic overuse. (19273784)
2009
16
The role of tonsillectomy in reducing recurrent pharyngitis: a systematic review. (19248931)
2009
17
Molecular characterization of group A Streptococcus maltodextrin catabolism and its role in pharyngitis. (18485073)
2008
18
Orbital myositis following streptococcal pharyngitis. (18377374)
2008
19
A meta-analysis of interventions to increase adherence to medication regimens for pediatric otitis media and streptococcal pharyngitis. (18296457)
2008
20
A 33-year-old man with pharyngitis, transient rash, and multiorgan system failure. (17873204)
2007
21
Orbital myositis following streptococcal pharyngitis in a pediatric patient. (15832845)
2005
22
Effect of sodium azulene sulfonate on capsaicin-induced pharyngitis in rats. (15667596)
2005
23
Versican expression in pharyngeal squamous cell carcinoma: an immunohistochemical study. (15220367)
2004
24
Diagnosis and management of adults with pharyngitis. (15126265)
2004
25
Telephonic back-up improves antibiotic compliance in acute tonsillitis/pharyngitis. (15013038)
2004
26
Follicular dendritic cell sarcoma of the pharyngeal region: histologic, cytologic, immunohistochemical, and ultrastructural study of three cases. (15614735)
2004
27
The respiratory and allergic manifestations of human myiasis caused by larvae of the sheep bot fly (Oestrus ovis): a report of 33 pharyngeal cases from southern Iran. (12662425)
2003
28
The effect of amoxicillin-clavulanate, cefixime and azithromycin on normal throat flora in children with group A streptococcal pharyngitis. (12862350)
2003
29
Intrahost sequence variation in the streptococcal inhibitor of complement gene in patients with human pharyngitis. (12599077)
2003
30
Cost-effectiveness of treatment options for prevention of rheumatic heart disease from Group A streptococcal pharyngitis in a pediatric population. (12202067)
2002
31
Accuracy of rapid strep testing in patients who have had recent streptococcal pharyngitis. (12150457)
2002
32
Transcription and expression of CD44 variant exons by oro-pharyngeal squamous cell carcinomas. (12239634)
2002
33
Therapeutic efficacy and clinical acceptability of fusafungine in follicular pharyngitis. (12487503)
2002
34
Acute pharyngitis. (11357847)
2001
35
Principles of appropriate antibiotic use for acute pharyngitis in adults. (11255529)
2001
36
Pattern of cardiovascular anomalies associated with esophageal atresia: support for a caudal pharyngeal arch neurocristopathy. (11641448)
2001
37
Periodic fever, aphthous stomatitis, pharyngitis, adenitis: a clinical review of a new syndrome. (10836162)
2000
38
Severe invasive group A beta-hemolytic streptococcus infection complicating pharyngitis: a case report and discussion. (10680323)
2000
39
The costs of testing for streptococcal pharyngitis in the office laboratory. (10632264)
2000
40
Myotomy for pharyngeal swallowing disorders. (10572577)
1999
41
Group A beta-hemolytic streptococcal pharyngitis in preschool children aged 3 months to 5 years. (10378093)
1999
42
Hoxa1 and Hoxb1 synergize in patterning the hindbrain, cranial nerves and second pharyngeal arch. (9463359)
1998
43
Comparison of clarithromycin suspension and amoxycillin syrup for the treatment of children with pharyngitis and/or tonsillitis. (9293051)
1997
44
Regulation of the phosphorylation of human pharyngeal cell proteins by group A streptococcal surface dehydrogenase: signal transduction between streptococci and pharyngeal cells. (9362524)
1997
45
Pharyngeal and swallowing disorders in infants. (7582886)
1995
46
Cefetamet pivoxil in the treatment of pharyngitis/tonsillitis in children and adults. (7518764)
1994
47
Cefpodoxime proxetil vs. penicillin V in pediatric streptococcal pharyngitis/tonsillitis. (8483620)
1993
48
Outbreaks of group A beta-hemolytic streptococcal pharyngitis in children: correlation of serotype T4 with scarlet fever. (1465577)
1992
49
Periodic fever associated with aphthous stomatitis, pharyngitis and cervical adenitis. (2710592)
1989
50
Group C beta-hemolytic streptococci causing pharyngitis and scarlet fever. (2772682)
1989

Genetic Variations for Pharyngitis

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Expression for genes affiliated with Pharyngitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pharyngitis

Search GEO for disease gene expression data for Pharyngitis.

Pathways for genes affiliated with Pharyngitis

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29KEGG, 37NCBI BioSystems Database
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Pathways related to Pharyngitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6GSTM1, GSTM3, ADH5, ADH1C
210.6FGF8, HOXA1, HOXB1
3
Hide members
10.6ADH5, ADH1C

Compounds for genes affiliated with Pharyngitis

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44Novoseek, 11DrugBank, 24HMDB
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Compounds related to Pharyngitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1vitamin a44 11 2412.6GSTM1, ADH5, ADH1C, FGF8
2hydrochloric acid44 2411.6GSTM1, GSTM3
3betaine aldehyde44 2411.5ADH1C, ADH5
4noradrenochrome44 2411.3GSTM1, GSTM3

GO Terms for genes affiliated with Pharyngitis

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16Gene Ontology
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Cellular components related to Pharyngitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563410.9GSC2, DGCR6, DGCR6L, NKRF, NKX2-6, NKX2-3

Biological processes related to Pharyngitis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1nitrobenzene metabolic processGO:01891610.8GSTM1, GSTM3
2cellular detoxification of nitrogen compoundGO:07045810.8GSTM3, GSTM1
3facial nucleus developmentGO:02175410.8HOXB1, HOXA1
4rhombomere 5 developmentGO:02157110.8HOXB1, HOXA1
5rhombomere 4 developmentGO:02157010.7HOXB1, HOXA1
6facial nerve structural organizationGO:02161210.7HOXA1, HOXB1
7xenobiotic catabolic processGO:04217810.7GSTM3, GSTM1
8ethanol oxidationGO:00606910.6ADH5, ADH1C
9organ morphogenesisGO:00988710.6DGCR6, TNF, SOX3
10pharyngeal system developmentGO:06003710.6FGF8, NKX2-6
11hypothalamus developmentGO:02185410.5SOX3, NKX2-6
12anatomical structure morphogenesisGO:00965310.3GSC2, FGF8, HOXA1

Molecular functions related to Pharyngitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:04356510.7GSC2, HOXA1, HOXB1, NKX2-3, NKX2-6
2alcohol dehydrogenase (NAD) activityGO:00402210.5ADH5, ADH1C
3glutathione bindingGO:04329510.3GSTM1, GSTM3

Products for genes affiliated with Pharyngitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pharyngitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet