MCID: PHR003
MIFTS: 62

Pharyngitis malady

Respiratory diseases, Oral diseases categories

Summaries for Pharyngitis

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Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An upper respiratory tract disease involving inflammation of the throat or pharynx resulting from bacterial, viral, fungal infections or irritants like pollutants or chemical substances and smoking. the infection is often referred to as "sore throat". the symptoms include pain during swallowing, enlarged tonsils coated with a white discharge, runny nose, cough and slight fever.

MalaCards: Pharyngitis, also known as chronic pharyngitis, is related to digeorge syndrome and velocardiofacial syndrome. An important gene associated with Pharyngitis is MATR3 (matrin 3), and among its related pathways are Drug metabolism - cytochrome P450 and Neural Crest Differentiation. The drugs guaifenesin and cefditoren and the compounds vitamin a and hydrochloric acid have been mentioned in the context of this disorder. Affiliated tissues include tonsil, testes and heart, and related mouse phenotypes are normal and craniofacial.

Wikipedia:63 The word pharyngitis /færɨnˈdʒaɪtɨs/ comes from the Greek word pharynx pharanx meaning throat and... more...

Aliases & Classifications for Pharyngitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases, Oral diseases


Aliases & Descriptions:

pharyngitis 8 10 44 60
chronic pharyngitis 8 60
acute pharyngitis 8 60
chronic pharyngitis and nasopharyngitis nos 8
chronic pharyngitis and nasopharyngitis 8
chronic pharyn/nasopharyngitis 8
chronic pharyngitis nos 8
persistent sore throat 8
sore throat - chronic 8
acute sore throat nos 8
chronic sore throat 8
pharyngitis - acute 8
disorder of pharynx 8
pharyngeal disorder 8
pharyngeal diseases 60
acute sore throat 8
inflamed throat 8


Related Diseases for Pharyngitis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Pharyngitis:



Diseases related to pharyngitis

Clinical Features for Pharyngitis

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Drugs & Therapeutics for Pharyngitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pharyngitis

Drug clinical trials:

Search ClinicalTrials for Pharyngitis

Search NIH Clinical Center for Pharyngitis

Search CenterWatch for Pharyngitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Pharyngitis

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Anatomical Context for Pharyngitis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Pharyngitis:

32
Tonsil, Testes, Heart, Bone, Endothelial, Cortex, Colon, Monocytes, Salivary gland, Thyroid, Myeloid, Lung, Lymph node, Pituitary

Animal Models for Pharyngitis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Pharyngitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000287310.7NKX2-6, POF1B, HOXB1, HOXA1, FGF8, GSC2
2MP:000538210.6FGF8, HOXA1, HOXB1, NKX2-3, TNF, SOX3
3MP:000538010.4SOX3, TNF, NKX2-6, HOXB1, HOXA1, FGF8

Publications for Pharyngitis

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Sources:
50PubMed
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Articles related to Pharyngitis:

(show top 50)    (show all 808)
idTitleAuthorsYear
1
Summaries for patients. A home score for streptococcal pharyngitis. (24344367)
2013
2
Incidence, clinical characteristics and outcome in Norwegian children with periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome; a population-based study. (23106338)
2013
3
A case of adult periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome associated with endocapillary proliferative glomerulonephritis. (20225048)
2013
4
Emergence of methicillin-resistant, vancomycin-intermediate Staphylococcus aureus among patients associated with group A Streptococcal pharyngitis infection in southern India. (23337611)
2013
5
Remote group A I^-hemolytic Streptococcal fasciitis and myositis: a rare complication from hematogenous spread of Streptococcal pharyngitis. (24069966)
2013
6
Clinical practice guideline for the diagnosis and management of group A streptococcal pharyngitis: 2012 update by the Infectious Diseases Society of America. (22965026)
2012
7
Treatment of pharyngeal non-Hodgkin lymphoma in a patient with Wiskott-Aldrich syndrome. (22052860)
2012
8
Comparison of bacterial communities in the throat swabs from healthy subjects and pharyngitis patients by terminal restriction fragment length polymorphism. (22322827)
2012
9
Accuracy and precision of the signs and symptoms of streptococcal pharyngitis in children: a systematic review. (22048053)
2012
10
Posterior pharyngeal wall squamous cell carcinoma arising in a patient with dyskeratosis congenita. (22932338)
2012
11
Tonsillectomy in children with periodic fever with aphthous stomatitis, pharyngitis, and adenitis syndrome. (21300374)
2011
12
The familial Mediterranean fever gene as a modifier of periodic fever, aphthous stomatitis, pharyngitis, and adenopathy syndrome. (20828792)
2011
13
Clinical guidelines for the use of adjuvant triamcinolone acetonide injections in oro-pharyngeal pemphigus vulgaris: the oral medicine point of view. (21114540)
2011
14
Laryngopharyngeal reflux might play a role on chronic nonspecific pharyngitis. (19629512)
2010
15
Double-blind comparison of two types of benzocaine lozenges for the treatment of acute pharyngitis. (20533760)
2010
16
Pharyngeal gonorrhea: an important reservoir of infection? (19911969)
2009
17
Toxic shock syndrome due to group A streptococcal pharyngitis and bacteremia in adults. (19812863)
2009
18
Single-dose extended-release oral azithromycin vs. 3-day azithromycin for the treatment of group A beta-haemolytic streptococcal pharyngitis/tonsillitis in adults and adolescents: a double-blind, double-dummy study. (19929975)
2009
19
Comparative Study of 5-Day and 10-Day Cefditoren Pivoxil Treatments for Recurrent Group A beta-Hemolytic Streptococcus pharyngitis in Children. (20041005)
2009
20
A single point acupuncture treatment at large intestine meridian: a randomized controlled trial in acute tonsillitis and pharyngitis. (19692805)
2009
21
Psoriasiform eruption and pharyngitis. (18283187)
2008
22
Severe pharyngitis in stockbreeders: an unusual presentation of brucellosis. (18397911)
2008
23
Evaluation and management of adult pharyngitis. (19137763)
2008
24
Randomized controlled studies and the treatment of middle-ear effusions and tonsillar pharyngitis: how random are the studies and what are their limitations? (18722208)
2008
25
MRI findings of rhabdomyolysis from streptococcal pharyngitis. (17503031)
2007
26
Lidocaine 8 mg sore throat lozenges in the treatment of acute pharyngitis. A new therapeutic option investigated in comparison to placebo treatment. (18193690)
2007
27
Pharyngeal carriage and antimicrobial resistance of Haemophilus influenzae in non-type-b-vaccinated healthy children attending day care centers in Turkey. (17308377)
2007
28
Pharyngeal pH monitoring in infants with laryngitis. (17967645)
2007
29
Recurrent aseptic encephalitis in periodic fever, aphthous stomatitis, pharyngitis and adenopathy (PFAPA) syndrome. (16645518)
2006
30
DiGeorge syndrome and pharyngeal apparatus development. (17041894)
2006
31
Prevalence of rectal, urethral, and pharyngeal chlamydia and gonorrhea detected in 2 clinical settings among men who have sex with men: San Francisco, California, 2003. (15937765)
2005
32
Effectiveness of oral dexamethasone in the treatment of moderate to severe pharyngitis in children. (15753273)
2005
33
Pharyngitis clinical prediction rules: effect of interobserver agreement: a MetroNet study. (15125623)
2004
34
Antibiotic resistance and genotypic characteristics of group a streptococci associated with acute pharyngitis in Korea. (15650374)
2004
35
Direct nucleic acid diagnostic tests for bacterial infectious diseases: streptococcal pharyngitis, pulmonary tuberculosis, vaginitis, chlamydial and gonococcal infections. (14758597)
2004
36
Steroids ineffective for pain in children with pharyngitis. (12899807)
2003
37
Pharyngeal dysesthesia in refractory complex partial epilepsy: new seizure or adverse effect of vagal nerve stimulation? (12790902)
2003
38
Hypereosinophilic syndrome in a child presenting as eosinophilic pharyngitis. (12972814)
2003
39
Inducible nitric oxide synthase expression in pharyngeal squamous cell carcinoma: relation to p53 expression, clinicopathological data, and survival. (12160278)
2002
40
Promoting condoms for oral sex: impact on pharyngeal gonorrhea among female brothel-based sex workers. (12035019)
2002
41
Acute pharyngitis. (11172144)
2001
42
Distribution of streptococcal inhibitor of complement variants in pharyngitis and invasive isolates in an epidemic of serotype M1 group A Streptococcus infection. (11170990)
2001
43
Performance of a predictive model for streptococcal pharyngitis in children. (11386959)
2001
44
Pharyngitis followed by hypoxia and sepsis: Lemierre syndrome. (11447525)
2001
45
Cap 'n' collar B cooperates with a small Maf subunit to specify pharyngeal development and suppress deformed homeotic function in the Drosophila head. (10952900)
2000
46
Herpetic pharyngitis with mammary and genital herpes due to sexual contact. (10384941)
1999
47
Pharyngitis, croup, and epiglottitis. (2196614)
1990
48
Relationship between posterior pharyngeal pouch and hiatus hernia. (5494681)
1970
49
Changes in the pharyngeal and esophageal musculature in oculopharyngeal muscular dystrophy. Report of 2 cases. (5358882)
1969
50
Two Lectures on Chronic Laryngitis and Chronic Pharyngitis: Their Pathology, Symptoms, and Treatment. (20751315)
1885

Genetic Variations for Pharyngitis

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Expression for genes affiliated with Pharyngitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pharyngitis

Search GEO for disease gene expression data for Pharyngitis.

Pathways for genes affiliated with Pharyngitis

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29KEGG, 37NCBI BioSystems Database
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Pathways related to Pharyngitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6GSTM1, GSTM3, ADH5, ADH1C
210.6FGF8, HOXA1, HOXB1
3
Hide members
10.6ADH5, ADH1C

Compounds for genes affiliated with Pharyngitis

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44Novoseek, 11DrugBank, 24HMDB
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Compounds related to Pharyngitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1vitamin a44 11 2412.6GSTM1, ADH5, ADH1C, FGF8
2hydrochloric acid44 2411.6GSTM1, GSTM3
3betaine aldehyde44 2411.5ADH1C, ADH5
4noradrenochrome44 2411.3GSTM1, GSTM3

GO Terms for genes affiliated with Pharyngitis

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16Gene Ontology
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Cellular components related to Pharyngitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563410.9GSC2, DGCR6, DGCR6L, NKRF, NKX2-6, NKX2-3

Biological processes related to Pharyngitis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1nitrobenzene metabolic processGO:01891610.8GSTM1, GSTM3
2cellular detoxification of nitrogen compoundGO:07045810.8GSTM3, GSTM1
3facial nucleus developmentGO:02175410.8HOXB1, HOXA1
4rhombomere 5 developmentGO:02157110.8HOXB1, HOXA1
5rhombomere 4 developmentGO:02157010.7HOXB1, HOXA1
6facial nerve structural organizationGO:02161210.7HOXA1, HOXB1
7xenobiotic catabolic processGO:04217810.7GSTM3, GSTM1
8ethanol oxidationGO:00606910.6ADH5, ADH1C
9organ morphogenesisGO:00988710.6DGCR6, TNF, SOX3
10pharyngeal system developmentGO:06003710.6FGF8, NKX2-6
11hypothalamus developmentGO:02185410.5SOX3, NKX2-6
12anatomical structure morphogenesisGO:00965310.3GSC2, FGF8, HOXA1

Molecular functions related to Pharyngitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:04356510.7GSC2, HOXA1, HOXB1, NKX2-3, NKX2-6
2alcohol dehydrogenase (NAD) activityGO:00402210.5ADH5, ADH1C
3glutathione bindingGO:04329510.3GSTM1, GSTM3

Products for genes affiliated with Pharyngitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pharyngitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet