MCID: PHR003
MIFTS: 57

Pharyngitis malady

Respiratory, Oral categories

Summaries for Pharyngitis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 An upper respiratory tract disease involving inflammation of the throat or pharynx resulting from bacterial, viral, fungal infections or irritants like pollutants or chemical substances and smoking. the infection is often referred to as "sore throat". the symptoms include pain during swallowing, enlarged tonsils coated with a white discharge, runny nose, cough and slight fever.

MalaCards: Pharyngitis, also known as chronic pharyngitis, is related to oral cancer and digeorge syndrome. An important gene associated with Pharyngitis is MATR3 (matrin 3), and among its related pathways are Drug metabolism - cytochrome P450 and Neural Crest Differentiation. The drugs guaifenesin and cefditoren and the compounds vitamin a and hydrochloric acid have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and small intestine, and related mouse phenotypes are normal and craniofacial.

Wikipedia:64 The word pharyngitis /færɨnˈdʒaɪtɨs/ comes from the Greek word pharynx pharanx meaning throat and... more...

Aliases & Classifications for Pharyngitis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory, Oral


Aliases & Descriptions:

pharyngitis 8 10 45 61
chronic pharyngitis 8 61
acute pharyngitis 8 61
chronic pharyngitis and nasopharyngitis nos 8
chronic pharyngitis and nasopharyngitis 8
chronic pharyn/nasopharyngitis 8
chronic pharyngitis nos 8
persistent sore throat 8
sore throat - chronic 8
acute sore throat nos 8
chronic sore throat 8
pharyngitis - acute 8
disorder of pharynx 8
pharyngeal disorder 8
pharyngeal diseases 61
acute sore throat 8
inflamed throat 8


Related Diseases for Pharyngitis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pharyngitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 220)
idRelated DiseaseScoreTop Affiliating Genes
1oral cancer30.4GSTM1, GSTM3, ADH1C
2digeorge syndrome30.3DGCR6, DGCR6L, DGCR, GSC2
3velocardiofacial syndrome30.3GSC2, NKX2-6, DGCR, DGCR6L, DGCR6
4stomatitis10.6
5aphthous stomatitis10.6
6tonsillitis10.6
7squamous cell carcinoma10.4
8gonorrhea10.4
9lemierre's syndrome10.3
10dysphagia10.3
11rheumatic fever10.3
12sleep apnea10.3
13rheumatic disease10.3
14oral squamous cell carcinoma10.2
15n syndrome10.2
16periodic fever, aphthous stomatitis, pharyngitis and adenitis10.2
17adult syndrome10.2
18guillain-barr� syndrome10.2
19cleft palate10.1
20shprintzen omphalocele syndrome10.1
21swallowing disorders10.1
22epiglottitis10.1
23oculopharyngeal muscular dystrophy10.1
24scarlet fever10.1
25esophageal atresia10.1
26arthritis10.1
27sinusitis10.1
28herpangina10.0
29follicular dendritic cell sarcoma10.0
30chronic laryngitis10.0
31infectious mononucleosis10.0
32toxic shock syndrome10.0
33oral candidiasis10.0
34pharyngoconjunctival fever10.0
35tularemia10.0
36oral pharyngeal disorders10.0
37ataxia10.0
38syncope10.0
39bacteremia10.0
40sepsis10.0
41periodic fever, familial10.0
42pharyngeal-cervical-brachial variant of guillain-barré syndrome10.0
43streptococcal toxic-shock syndrome10.0
44laryngeal carcinoma10.0GSTM1, GSTM3, ADH1C
45pulmonary disease, chronic obstructive10.0TNF, LACTB, GSTM1
46hepatocellular carcinoma10.0GSTM1
47primary open angle glaucoma10.0GSTM1
48endophthalmitis10.0LACTB
49bone fracture9.9
50pulmonary tuberculosis9.9

Graphical network of the top 20 diseases related to Pharyngitis:



Diseases related to pharyngitis

Clinical Features for Pharyngitis

Drugs & Therapeutics for Pharyngitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pharyngitis

Drug clinical trials:

Search ClinicalTrials for Pharyngitis

Search NIH Clinical Center for Pharyngitis

Search CenterWatch for Pharyngitis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Pharyngitis

Anatomical Context for Pharyngitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Pharyngitis:

33
Lung, Heart, Small intestine, Thyroid, Tonsil, Monocytes, T cells

Animal Models for Pharyngitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Pharyngitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000287310.7NKX2-6, POF1B, HOXB1, HOXA1, FGF8, GSC2
2MP:000538210.6FGF8, HOXA1, HOXB1, NKX2-3, TNF, SOX3
3MP:000538010.4SOX3, TNF, NKX2-6, HOXB1, HOXA1, FGF8

Publications for Pharyngitis

Sources:
51PubMed
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Articles related to Pharyngitis:

(show top 50)    (show all 557)
idTitleAuthorsYear
1
Rapid-antigen detection tests for group a streptococcal pharyngitis: revisiting false-positive results using polymerase chain reaction testing. (23465407)
2013
2
Comparison among nasopharyngeal swab, nasal wash, and oropharyngeal swab for respiratory virus detection in adults with acute pharyngitis. (23786598)
2013
3
Summaries for patients. A home score for streptococcal pharyngitis. (24344367)
2013
4
Incidence, clinical characteristics and outcome in Norwegian children with periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome; a population-based study. (23106338)
2013
5
No evidence for the effectiveness of systemic corticosteroids in acute pharyngitis, community-acquired pneumonia and acute otitis media. (22993127)
2013
6
Streptococcal pharyngitis: a prospective study of compliance and complications. (22778988)
2012
7
Streptococcal pharyngitis leading to corneal ulceration. (22360434)
2012
8
Association of pharyngitis with oral antibiotic use for the treatment of acne: a cross-sectional and prospective cohort study. (22105812)
2012
9
Epidemiological characterization of Streptococcus pyogenes isolated from patients with multiple onsets of pharyngitis. (21362024)
2011
10
Pharyngitis guidelines. (21703687)
2011
11
Streptococcus pyogenes emm types and subtypes of isolates from paediatric asymptomatic carriers and children with pharyngitis. (21344154)
2011
12
Epidural pneumatosis of the cervicothoracic spine associated with transient upper motor neuron findings complicating Haemophilus influenzae pharyngitis, bronchitis, and mediastinitis. (20574262)
2010
13
Surgical outcomes and histology findings after tonsillectomy in children with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome. (20015793)
2010
14
Effects of chlorhexidine/benzydamine mouth spray on pain and quality of life in acute viral pharyngitis: a prospective, randomized, double-blind, placebo-controlled, multicenter study. (21086279)
2010
15
Laryngopharyngeal reflux might play a role on chronic nonspecific pharyngitis. (19629512)
2010
16
Double-blind comparison of two types of benzocaine lozenges for the treatment of acute pharyngitis. (20533760)
2010
17
Toxic shock syndrome due to group A streptococcal pharyngitis and bacteremia in adults. (19812863)
2009
18
Single-dose extended-release oral azithromycin vs. 3-day azithromycin for the treatment of group A beta-haemolytic streptococcal pharyngitis/tonsillitis in adults and adolescents: a double-blind, double-dummy study. (19929975)
2009
19
Severe pharyngitis in stockbreeders: an unusual presentation of brucellosis. (18397911)
2008
20
Parapharyngeal abscess in a previously tonsillectomised child with periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome: first reported case. (18036284)
2008
21
Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome is not always successful. (18410791)
2008
22
A meta-analysis of interventions to increase adherence to medication regimens for pediatric otitis media and streptococcal pharyngitis. (18296457)
2008
23
The evidence base for cephalosporin superiority over penicillin in streptococcal pharyngitis. (17292576)
2007
24
Quality of care in the retail health care setting using national clinical guidelines for acute pharyngitis. (18006426)
2007
25
Group A streptococcal pharyngitis and penicillin G. (17278078)
2007
26
Recurrent aseptic encephalitis in periodic fever, aphthous stomatitis, pharyngitis and adenopathy (PFAPA) syndrome. (16645518)
2006
27
Pharyngitis: how and why. (17101955)
2006
28
Group A streptococcal pharyngitis serotype surveillance in North America, 2000-2002. (15306998)
2004
29
Real-time PCR investigation into the importance of Fusobacterium necrophorum as a cause of acute pharyngitis in general practice. (15358827)
2004
30
Clinical and bacteriological implications of macrolide resistance in group A streptococcal pharyngitis. (12951332)
2003
31
Role of the microbiology laboratory in diagnosis and management of pharyngitis. (12904340)
2003
32
Appropriate antibiotic use for acute pharyngitis. (11955037)
2002
33
Practice guidelines for the diagnosis and management of group A streptococcal pharyngitis. Infectious Diseases Society of America. (12087516)
2002
34
Therapeutic efficacy and clinical acceptability of fusafungine in follicular pharyngitis. (12487503)
2002
35
Macrolide therapy of group A streptococcal pharyngitis: 10 days of macrolide therapy (clarithromycin) is more effective in streptococcal eradication than 5 days (azithromycin). (11360224)
2001
36
Unexplained reduced microbiological efficacy of intramuscular benzathine penicillin G and of oral penicillin V in eradication of group a streptococci from children with acute pharyngitis. (11694700)
2001
37
Open-Label, parallel-group, multicenter, randomized study of cefprozil versus erythromycin in children with group A streptococcal pharyngitis/tonsillitis. (11768840)
2001
38
Pharyngitis followed by hypoxia and sepsis: Lemierre syndrome. (11447525)
2001
39
Syndrome of Periodic Fever, Aphthous stomatitis, Pharyngitis, and Adenitis (PFAPA)--what it isn't. What is it? (10393593)
1999
40
Managing streptococcal pharyngitis: a review of clinical decision-managing strategies, diagnostic evaluation, and treatment. (10504921)
1999
41
Herpetic pharyngitis with mammary and genital herpes due to sexual contact. (10384941)
1999
42
Group A streptococcal pharyngitis in adults 30 to 65 years of age. (10342895)
1999
43
Causes, diagnosis and treatment of pharyngitis. (10470516)
1999
44
Respiratory failure as a complication of pharyngitis: Lemierre's syndrome. (10608325)
1999
45
Group C streptococcal subdural empyema in a healthy man: possible complication of pharyngitis. (8099504)
1993
46
Treatment of pharyngitis and tonsillitis with cefprozil: review of three multicenter trials. (1617042)
1992
47
Therapy for pharyngitis and tonsillitis caused by group A beta-hemolytic streptococci: a meta-analysis comparing the efficacy and safety of cefadroxil monohydrate versus oral penicillin V. (1468091)
1992
48
Monocytes and polymorphonuclear neutrophils of patients with streptococcal pharyngitis express increased numbers of type I IgG Fc receptors. (2147695)
1990
49
Streptococcal pharyngitis and scarlet fever. (655147)
1978
50
Two Lectures on Chronic Laryngitis and Chronic Pharyngitis: Their Pathology, Symptoms, and Treatment. (20751317)
1885

Genetic Variations for Pharyngitis

Expression for genes affiliated with Pharyngitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pharyngitis

Search GEO for disease gene expression data for Pharyngitis.

Pathways for genes affiliated with Pharyngitis

Sources:
30KEGG, 38NCBI BioSystems Database
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Pathways related to Pharyngitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6GSTM1, GSTM3, ADH5, ADH1C
210.6FGF8, HOXA1, HOXB1
3
Hide members
10.6ADH5, ADH1C

Compounds for genes affiliated with Pharyngitis

Sources:
45Novoseek, 11DrugBank, 24HMDB
See all sources

Compounds related to Pharyngitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1vitamin a45 11 2412.6GSTM1, ADH5, ADH1C, FGF8
2hydrochloric acid45 2411.6GSTM1, GSTM3
3betaine aldehyde45 2411.5ADH1C, ADH5
4noradrenochrome45 2411.3GSTM1, GSTM3

GO Terms for genes affiliated with Pharyngitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Pharyngitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563410.9GSC2, DGCR6, DGCR6L, NKRF, NKX2-6, NKX2-3

Biological processes related to Pharyngitis according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1nitrobenzene metabolic processGO:01891610.8GSTM1, GSTM3
2cellular detoxification of nitrogen compoundGO:07045810.8GSTM3, GSTM1
3facial nucleus developmentGO:02175410.8HOXB1, HOXA1
4rhombomere 5 developmentGO:02157110.8HOXB1, HOXA1
5rhombomere 4 developmentGO:02157010.7HOXB1, HOXA1
6facial nerve structural organizationGO:02161210.7HOXA1, HOXB1
7xenobiotic catabolic processGO:04217810.7GSTM3, GSTM1
8ethanol oxidationGO:00606910.6ADH5, ADH1C
9organ morphogenesisGO:00988710.6DGCR6, TNF, SOX3
10pharyngeal system developmentGO:06003710.6FGF8, NKX2-6
11hypothalamus developmentGO:02185410.5SOX3, NKX2-6
12anatomical structure morphogenesisGO:00965310.3GSC2, FGF8, HOXA1

Molecular functions related to Pharyngitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:04356510.7GSC2, HOXA1, HOXB1, NKX2-3, NKX2-6
2alcohol dehydrogenase (NAD) activityGO:00402210.5ADH5, ADH1C
3glutathione bindingGO:04329510.3GSTM1, GSTM3

Products for genes affiliated with Pharyngitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pharyngitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet