Pheochromocytoma malady

NIH Rare Diseases: Pheochromocytomas are rare tumors of the adrenal glands, which are located right above the kidneys. Although they are usually not cancerous (benign), pheochromocytomas often cause the adrenal glands to make too many stress hormones called epinephrines and norepinephrines. This can lead to high blood pressure and cause symptoms such as severe headaches, irritability, sweating, rapid heart rate, nausea, vomiting, weight loss, weakness, chest pain, and a feeling of anxiety. Rarely, this kind of tumor occurs outside the adrenal gland, usually somewhere in the abdomen, and are called extra-adrenal pheochromocytomas or paragangliomas. Pheochromocytomas can occur in certain familial genetic syndromes.³⁰

MalaCards: Pheochromocytoma, also known as chromaffin paraganglioma, is related to paraganglioma and multiple endocrine neoplasia. An important gene associated with Pheochromocytoma is SDHB (succinate dehydrogenase complex, subunit B, iron sulfur (Ip)), and among its related pathways are Development_GDNF family signaling and Development FGFR signaling pathway. The drugs propranolol and propranolol hydrochloride and the compounds calcium and forskolin have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and kidney, and related mouse phenotypes are nervous system and behavior/neurological.

MedlinePlus: Pheochromocytoma is a rare tumor that usually starts in the cells of one of your adrenal glands. although they are usually benign, pheochromocytomas often cause the adrenal gland to make too many hormones. this can lead to high blood pressure and cause symptoms such as headaches sweating pounding of the heart chest pain a feeling of anxiety sometimes pheochromocytoma is part of another condition called multiple endocrine neoplasia syndrome (men). people with men often have other cancers and other problems involving hormones. surgery is the most common treatment. other options include radiation therapy and chemotherapy. nih: national cancer institute²³

Wikipedia: A pheochromocytoma or phaeochromocytoma (PCC) is a neuroendocrine tumor of the medulla of the adrenal...⁴⁴ more...

OMIM: 171300

pheochromocytoma 7 44 30 17 33 32 23 43 chromaffin paraganglioma 30 medullary paraganglioma 30

chromaffin cell tumor 30 chromaffin tumor 30 chromaffinoma 30

Diseases related to pheochromocytoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 879)

id	Related Disease	Score	Top Affiliating Genes
1	paraganglioma	39.0	NCAM1, REN, RET, KIT, VIP, BSG
2	multiple endocrine neoplasia	35.7	RET, VIP, VHL, SDHB, SDHC, SDHD
3	neuronitis	34.2	PIK3C2A, NCAM1, REN, REST, RET, KIT
4	carcinoma	34.1	PIK3C2A, NCAM1, REN, REST, RET, KIT
5	neurofibromatosis	34.1	RET, KIT, VHL, RAF1, SDHB, SDHC
6	ganglioneuroma	32.7	NCAM1, RET, VIP, VHL, MYCN, SCG2
7	multiple endocrine neoplasia type 2a	32.6	RET, VHL, CALCA, NF1, SHC1, GFRA1
8	von hippel-lindau disease	32.5	REN, RET, KIT, SETD2, VIP, VHL
9	cushing's syndrome	32.1	REN, RET, LEP, CHGA, INHA, MEN1
10	neuroendocrine tumor	32.1	NCAM1, RET, VIP, MYCN, RAF1, SDHD
11	neuroblastoma	31.2	NCAM1, REST, RET, KIT, KIF1B, PCSK2
12	adrenocortical tumor	30.8	RET, VHL, VEGFA, MYC, SDHB, SDHC
13	parkinson's disease	30.6	GCH1, CHRNA7, CHAT, BAD, MTR, INSR
14	carcinoid tumors	30.3	NCAM1, RET, PCSK2, PCSK1, VIP, RAF1
15	papillary thyroid carcinoma	30.1	RET, RAF1, RAN, LGALS3, S100A1, CDH1
16	adrenocortical carcinoma	30.1	VIP, UTS2, SCARB1, CHKA, CHGA, MKI67
17	thyroiditis	30.0	PIK3C2A, NCAM1, REN, RET, KIT, PCSK2
18	thyroid medullary carcinoma	29.6	NCAM1, RET, LGALS3, CHGA, MSH2, CDH2
19	pancreatic islet cell tumors	29.2	RET, VIP, CHGA, MEN1, IGF2, IAPP
20	familial medullary thyroid carcinoma	29.2	RET, SDHB, SDHC, SDHD, FOS, MAPK3
21	pulmonary hypertension	29.1	SETD2, VIP, VIPR1, BMP4, UTS2, FLT1
22	merkel cell carcinoma	29.1	NCAM1, KIT, CHGA, ENO2, MAP2, MAPK10
23	ganglioneuroblastoma	29.0	VIP, MYCN, CHGA, S100B, MBP, ENO2
24	primary hyperparathyroidism	28.5	RET, SCT, CHGA, CD36, MEN1, IGFBP1
25	carney triad	28.3	KIT, SDHA, SDHB, SDHC, SDHD, DES
26	hypertension	28.3	PIK3C2A, NCAM1, REN, RET, KIT, KIF1B
27	adrenal carcinoma	27.9	LEP, MKI67, ENO2, CCND1, CRH, SYP
28	renal cell carcinoma	27.4	RET, KIT, SETD2, BSG, VHL, VEGFA
29	immunodeficiency	27.1	VIP, SDHA, INHA, INSR, IL13, IL6
30	hyperparathyroidism	27.0	RET, SERPINE1, VIP, VIPR1, VEGFA, SDHB
31	hypoxia	26.8	PIK3C2A, REN, RET, KIT, SETD2, SERPINE1
32	adenoma	26.6	NCAM1, REN, RET, KIT, PCSK2, PCSK1
33	hypercalcemia	26.2	LIF, SCT, CHGA, CD36, FGF2, MEN1
34	breast cancer	26.1	MYC, CDK2, CDKN1B, CDK4, CDH1, CCND1
35	differentiating neuroblastoma	26.1	RET, MYCN, BCL2, CHGA, FOS, ASCL1
36	mediastinitis	25.9	KIT, MYC, SDHB, SDHD, S100A1, JUN
37	pancreatitis	25.9	PIK3C2A, NCAM1, REN, REST, RET, KIT
38	polycythemia	25.5	KIT, SERPINE1, VHL, VEGFA, MLN, IL6
39	pituitary adenoma	25.3	NCAM1, RET, KIT, PCSK2, PCSK1, VIP
40	hemangioma	24.9	RET, SETD2, VHL, VEGFA, MYC, SDHAF2
41	malignant fibrous histiocytoma	24.7	BSG, VEGFA, BCL2, S100A1, S100B, MSH2
42	fibrous histiocytoma	24.4	BSG, VEGFA, BCL2, S100A1, S100B, MSH2
43	histiocytoma	24.4	BSG, VEGFA, BCL2, S100A1, S100B, MSH2
44	pulmonary edema	24.3	PIK3C2A, REN, RET, VEGFA, IL1B, IL6
45	thyroid carcinoma	23.9	RET, KIF1B, SERPINE1, BSG, VHL, VEGFA
46	adenocarcinoma	23.8	PIK3C2A, NCAM1, RET, KIT, SETD2, SERPINE1
47	retinoblastoma	23.0	NCAM1, KIT, VIP, BSG, VHL, VEGFA
48	hepatitis	22.9	PIK3C2A, NCAM1, REN, KIT, KIF1B, GCGR
49	cholesterol	22.7	PIK3C2A, REN, SERPINE1, VIP, BSG, VEGFA
50	graves' disease	22.4	MYC, BCL2, SDHA, LGALS3, CD36, CDKN1B

Clinical features from OMIM: 171300

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 metyrosine, propranolol, propranolol hydrochloride

MalaCards organs/tissues related to pheochromocytoma:

²²

MGI Mouse Phenotypes related to pheochromocytoma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system phenotype	MP:0003631	14.3	REN, REST, KIT, KIF1B, MYC, MYCN
2	behavior/neurological phenotype	MP:0005386	14.0	NCAM1, REN, KIT, KIF1B, PCSK2, PCSK1
3	normal phenotype	MP:0002873	13.3	REN, RET, GCGR, VIP, VHL, VEGFA
4	mortality/aging	MP:0010768	12.5	PIK3C2A, NCAM1, REN, REST, RET, KIF1B
5	endocrine/exocrine gland phenotype	MP:0005379	12.5	RET, PCSK2, PCSK1, VIPR1, VGF, SCG5
6	growth/size phenotype	MP:0005378	12.3	PIK3C2A, REN, REST, RET, KIT, PCSK1
7	respiratory system phenotype	MP:0005388	12.2	RET, KIF1B, MYCN, LIF, SCG5, CHRNA7
8	embryogenesis phenotype	MP:0005380	12.1	REST, RET, KIT, SETD2, VHL, MYC
9	craniofacial phenotype	MP:0005382	11.6	KIT, MYCN, BMP4, FRS2, CDH5, ASCL1
10	integument phenotype	MP:0010771	11.2	KIT, KIF1B, PCSK2, VHL, VGF, MYC
11	hematopoietic system phenotype	MP:0005397	11.1	KIT, PCSK1, VHL, BNIP3, MYCN, BMP4
12	taste/olfaction phenotype	MP:0005394	10.9	INSM1, ENO2, MAPK1, HTT, CASP3, CASP9
13	renal/urinary system phenotype	MP:0005367	10.7	REN, RET, KIT, VHL, MYCN, BMP4
14	immune system phenotype	MP:0005387	10.5	REN, KIT, PCSK1, BSG, RAMP2, RAF1
15	hearing/vestibular/ear phenotype	MP:0005377	10.1	KIT, MYC, BMP4, BCL2, UCN, CDKN1B
16	digestive/alimentary phenotype	MP:0005381	10.0	RET, KIT, PCSK1, VIPR1, VHL, VEGFA
17	liver/biliary system phenotype	MP:0005370	9.9	KIT, VHL, VEGFA, MYCN, BMP4, RAMP2
18	no phenotypic analysis	MP:0003012	9.8	REST, RET, VEGFA, MYC, BMP4, RAMP2
19	limbs/digits/tail phenotype	MP:0005371	9.6	RET, KIT, VHL, VEGFA, MYCN, BMP4
20	reproductive system phenotype	MP:0005389	9.4	REN, RET, PCSK2, PCSK1, GCGR, VIP
21	homeostasis/metabolism phenotype	MP:0005376	9.3	PIK3C2A, REN, RET, KIT, PCSK2, PCSK1
22	pigmentation phenotype	MP:0001186	9.1	KIT, MYC, BCL2, LEP, CDKN1B, CDKN2A
23	skeleton phenotype	MP:0005390	9.0	KIT, KIF1B, VHL, VEGFA, MYC, MYCN
24	vision/eye phenotype	MP:0005391	8.6	NCAM1, REST, KIT, VEGFA, MYCN, BMP4
25	cellular phenotype	MP:0005384	8.3	NCAM1, REST, RET, KIT, PCSK2, PCSK1
26	muscle phenotype	MP:0005369	7.6	REN, RET, KIT, KIF1B, PCSK1, VHL
27	cardiovascular system phenotype	MP:0005385	7.5	REN, RET, KIT, PCSK2, PCSK1, SETD2
28	adipose tissue phenotype	MP:0005375	7.2	PIK3C2A, PCSK1, GCGR, SERPINE1, VGF, MYC
29	tumorigenesis	MP:0002006	5.4	RET, KIT, SERPINE1, VHL, MYC, BCL2

Articles related to pheochromocytoma:

(show top 50)    (show all 514)

id	Title	Authors	Year	Affiliating Genes
1	Expression of galectin-3, nm-23, and cyclooxygenase-2 could potentially discriminate between benign and malignant pheochromocytoma. (21350102)	Saffar H.... Tavangar S.M.	2011	LGALS3, NME1
2	A tissue microarray-based comparative analysis of nov el and traditional immunohistochemical markers in the distinction between adren al cortical lesions and pheochromocytoma. (20154585)	Sangoi A.R.... McKenney J.K.	2010	NR5A1, SYP, CALB2
3	Low sensitivity of glucagon provocative testing for d iagnosis of pheochromocytoma. (19897672)	Lenders J.W.... Eisenhofer G.	2010	GCGR
4	Mutation screening of VHL gene in a family with malig nant bilateral pheochromocytoma: from isolated familial pheochromocytoma to von Hippel-Lindau disease. (19649731)	Hasani-Ranjbar S.... Larijani B.	2009	VHL
5	Expression of the p16INK4A/Cdkn2a gene is prevalently downregulated in human pheochromocytoma tumor specimens. (19110720)	Muscarella P.... Li J.	2008	CDKN2A
6	Should genetic testing be performed in each patient with sporadic pheochromocytoma at presentation? (19029228)	Pigny P.... Porchet N.	2008	RET, VHL, SDHB
7	A giant cystic pheochromocytoma of the adrenal gland. (18322657)	Pan Z.... Sharma P.	2008	SDHB
8	Uncommon clinical presentations of pheochromocytoma and paraganglioma in two different patients affected by two distinct novel VHL germline mutations. (18031321)	Ercolino T.... Mannelli M.	2008	SDHC
9	Genetic screening for pheochromocytoma: should SDHC gene analysis be included? (17557926)	Mannelli M.... Parenti G.	2007	SDHC
10	Familial nonsyndromic pheochromocytoma. (17102081)	Opocher G.... Mantero F.	2006	RET, VHL, SDHB
11	ZM336372, a Raf-1 activator, inhibits growth of pheochromocytoma cells. (16603190)	Kappes A.... Chen H.	2006	RAF1, CHGA
12	Can quantification of VMAT and SSTR expression be helpful for planning radionuclide therapy of malignant pheochromocytomas? (17102116)	KAPlby L.... Ahlman H.	2006	SST
13	Alpha 2-adrenergic receptors decrease DNA replication and cell proliferation and induce neurite outgrowth in transfected rat pheochromocytoma cells. (17192578)	Karkoulias G.... Flordellis C.S.	2006	ADRA2C
14	The effects of urotensin-II on proliferation of pheochromocytoma cells and mRNA expression of urotensin-II and its receptor in pheochromocytoma tissues. (17102097)	Zeng Z.P.... Liu C.	2006	UTS2R, UTS2
15	The von Hippel-Lindau (VHL) germline mutation V84L manifests as early-onset bilateral pheochromocytoma. (16502427)	Abbott M.-A.... Greenstein R.M.	2006	VHL
16	Deletions and altered expression of the RIZ1 tumour suppressor gene in 1p36 in pheochromocytomas and abdominal paragangliomas. (15809732)	Geli J.... Larsson C.	2005	PRDM2
17	Expression of urotensin II and G-protein coupled receptor 14 mRNA in human pheochromocytoma tissues (16178439)	Liu G.Q.... Liu C.	2005	UTS2R, UTS2
18	Imaging of pheochromocytoma and paraganglioma. (15883712)	Brink I.... Bley T.A.	2005	SST
19	Distinct gene expression profiles in norepinephrine- and epinephrine-producing hereditary and sporadic pheochromocytomas: activation of hypoxia-driven angiogenic pathways in von Hippel-Lindau syndrome. (15613462)	Eisenhofer G.... Elkahloun A.G.	2004	PTGS1, CDH5, MMP1
20	Intragenic allelic loss and promoter hypermethylation of the RIZ1 tumor suppressor gene in parathyroid tumors and pheochromocytomas. (14668725)	Carling T.... Huang S.	2003	MEN1, PRDM2
21	The gene expression profiling of sporadic pheochromocytoma and novel full-length cDNAs cloning. (14713272)	Yang Y.-S.... Chen J.-L.	2003	MAP1LC3B, TATDN1
22	Distinct protein kinase C isoforms mediate regulation of vascular endothelial growth factor expression by A2A adenosine receptor activation and phorbol esters in pheochromocytoma PC12 cells. (12590138)	Gardner A.M.... Olah M.E.	2003	PRKCA, VEGFA, ADORA2A
23	Identification of the secretogranin II-derived peptide EM66 in pheochromocytomas as a potential marker for discriminating benign versus malignant tumors. (12788858)	Yon L.... Anouar Y.	2003	TH, SCG2
24	Pheochromocytoma. (12943613)	Pederson L.C.... Lee J.E.	2003	SST
25	Alterations of the SDHD gene locus in midgut carcinoids, Merkel cell carcinomas, pheochromocytomas, and abdominal paragangliomas. (12007193)	Kytoelae S.... Larsson C.	2002	SDHD
26	Pheochromocytoma producing vasoactive intestinal peptide. (11795252)	Smith S.L.... Scolapio J.S.	2002	VIP
27	5'-End RET splicing: absence of variants in normal tissues and intron retention in pheochromocytomas. (12187076)	Le Hir H.... Thermes C.	2002	RET
28	Lead exposure in pheochromocytoma (PC12) cells alters neural differentiation and Sp1 DNA-binding. (11307851)	Crumpton T.... Barone S.	2001	SP1
29	Disappearance rate of catecholamines, total metanephrines, and neuropeptide Y from the plasma of patients after resection of pheochromocytoma. (11375294)	Grouzmann E.... Buclin T.	2001	NPY
30	Genetic aspects of pheochromocytoma. (11308996)	Koch C.A.... Pacak K.	2001	RET, NF1, VHL
31	Relative expression of the RET9 and RET51 isoforms in human pheochromocytomas. (10838497)	Le Hir H.... Thermes C.	2000	RET
32	Multiple endocrine neoplasia (MEN)--an overview and case report--patient with sporadic bilateral pheochromocytoma, hyperparathyroidism and marfanoid habitus. (11205236)	Fassbender W.J.... Kaiser H.E.	2000	RET, MEN1
33	Leukocyte common-antigen-related tyrosine phosphatase receptor: altered expression of mRNA and protein in the New England Deaconess Hospital rat line exhibiting spontaneous pheochromocytoma. (10657947)	Yang T.... Longo F.M.	2000	PTPRF, ACP1, PTS
34	Clinicopathological study of pheochromocytoma of the urinary bladder: immunohistochemical, flow cytometric and ultrastructural findings with review of the literature. (10632931)	Kato H.... Aizawa S.	1999	S100A1
35	Lack of leptin suppression in response to hypersecret ion of catecholamines in pheochromocytoma patients. (10337850)	BAPttner A.... Bornstein S.R.	1999	LEP
36	Differences in allelic distribution of two polymorphisms in the VHL-associated gene CUL2 in pheochromocytoma patients without somatic CUL2 mutations. (10487688)	Duerr E.M.... Eng C.	1999	RET, CUL2
37	Pheochromocytoma and sub-clinical Cushing's syndrome during pregnancy: diagnosis, medical pre-treatment and cure by laparoscopic unilateral adrenalectomy. (10475154)	Finkenstedt G.... Janetschek G.	1999	IL6
38	Comparative study between normal rat chromaffin and PC12 rat pheochromocytoma cells: production and effects of corticotropin-releasing hormone. (9003004)	Venihaki M.... Margioris A.N.	1997	NGF, CRH
39	Elevated amyloid beta protein(1-40) level induces CREB phosphorylation at serine-133 via p44/42 MAP kinase (Erk1/2)-dependent pathway in rat pheochromocytoma PC12 cells. (9126327)	Sato N.... Ogihara T.	1997	MAPK3, CREB1, PSMC6
40	Activation of sphingosine kinase in pheochromocytoma PC12 neuronal cells in response to trophic factors. (9395290)	Rius R.A.... Spiegel S.	1997	NGF
41	Spontaneous remission of ectopic Cushing's syndrome due to pheochromocytoma: a case report. (8921826)	Loh K.C.... Shlossberg A.H.	1996	POMC
42	Tumor-specific mutations in the tyrosine kinase domain of the RET proto-oncogene in pheochromocytomas of sporadic type. (7627271)	Yoshimoto K.... Itakura M.	1995	RET
43	Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma. (1318039)	Kitamura K.... Eto T.	1992	CALCA, VIP, CALCB
44	Plasma chromogranin A + B, neuropeptide Y and catecholamines in pheochromocytoma patients. (2040871)	GrAPndal S.... Theodorsson E.	1991	NPY, CHGA
45	The hydroxylation of phenylalanine and tyrosine by tyrosine hydroxylase from cultured pheochromocytoma cells. (1678741)	Ribeiro P.... KAUFMAN S.	1991	TH
46	Chromogranin A storage and secretion: sensitivity and specificity for the diagnosis of pheochromocytoma. (1988765)	Hsiao R.J.... O'Connor D.T.	1991	CHGA
47	Post-translational processing and secretory pathway o f human atriopeptin in rat pheochromocytoma cells. (1828150)	Shiono S.... Needleman P.	1991	NGF
48	Plasma calcitonin gene-related peptide and atrial natriuretic peptide levels during resection of pheochromocytoma. (1836071)	Fedorak I.... Glisson S.	1991	CALCA, NPPA
49	Immunoreactive corticotropin-releasing hormone, growth hormone-releasing hormone, somatostatin, and peptide histidine methionine are present in adrenal pheochromocytomas, but not in extra-adrenal pheochromocytoma. (1969422)	Sasaki A.... Yoshinaga K.	1990	SST, CRH
50	A long survived case of malignant pheochromocytoma treated with alpha-methyl-p-tyrosine and midaglizol (DG-5128) (1975832)	Okada S.... Ishihara H.	1990	TH

Genes related to pheochromocytoma according to GeneCards:

(show top 50)    (show all 330)

id	Symbol	Description	Score	GeneCards Section Context
1	SDHB	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	11.1	Orthologs, Publications, Summaries
2	TMEM127	transmembrane protein 127	11.0	Publications, Summaries
3	ADM	adrenomedullin	11.0	Expressions, Publications, Summaries
4	MAX	MYC associated factor X	11.0	Summaries, Publications
5	IFRD1	interferon-related developmental regulator 1	11.0	Aliases & Descriptions
6	GDNF	glial cell derived neurotrophic factor	11.0	Publications
7	SDHD	succinate dehydrogenase complex, subunit D, integral membrane protein	11.0	Publications
8	SDHC	succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa	11.0	Publications
9	VHL	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	11.0	Publications
10	SST	somatostatin	11.0	Publications
11	PNMT	phenylethanolamine N-methyltransferase	11.0	Publications
12	RET	ret proto-oncogene	11.0	Publications
13	CHGB	chromogranin B (secretogranin 1)	11.0	Publications, Expressions
14	UTS2R	urotensin 2 receptor	11.0	Publications
15	CHGA	chromogranin A (parathyroid secretory protein 1)	11.0	Publications
16	SIGLEC7	sialic acid binding Ig-like lectin 7	11.0	Publications
17	SDHAF2	succinate dehydrogenase complex assembly factor 2	11.0
18	VGF	VGF nerve growth factor inducible	11.0	Publications
19	ASCL1	achaete-scute complex homolog 1 (Drosophila)	11.0	Publications
20	SCG2	secretogranin II	11.0	Publications
21	RAMP2	receptor (G protein-coupled) activity modifying protein 2	11.0	Publications
22	GCGR	glucagon receptor	11.0	Publications
23	PMCH	pro-melanin-concentrating hormone	11.0
24	RIT1	Ras-like without CAAX 1	11.0
25	UTS2	urotensin 2	11.0	Publications
26	SSTR4	somatostatin receptor 4	11.0	Publications
27	SYT4	synaptotagmin IV	11.0
28	SSTR1	somatostatin receptor 1	11.0	Publications
29	IGFBP6	insulin-like growth factor binding protein 6	11.0	Publications
30	DBH	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	11.0	Publications
31	PENK	proenkephalin	11.0	Publications
32	SYP	synaptophysin	11.0	Publications
33	KHSRP	KH-type splicing regulatory protein	11.0	Publications
34	STC1	stanniocalcin 1	11.0	Publications
35	TH	tyrosine hydroxylase	11.0	Publications
36	NGF	nerve growth factor (beta polypeptide)	11.0	Publications
37	UCN	urocortin	11.0	Publications
38	UCN3	urocortin 3 (stresscopin)	11.0
39	P2RX2	purinergic receptor P2X, ligand-gated ion channel, 2	11.0
40	FH	fumarate hydratase	11.0	Publications
41	HCRTR1	hypocretin (orexin) receptor 1	11.0	Publications
42	SDHA	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	11.0	Publications
43	NPY	neuropeptide Y	11.0	Publications
44	ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	11.0	Publications
45	MLN	motilin	11.0	Publications
46	MEN1	multiple endocrine neoplasia I	11.0	Publications
47	INHBA	inhibin, beta A	11.0	Publications
48	SSTR5	somatostatin receptor 5	11.0	Publications
49	SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	11.0	Publications
50	SLC18A3	solute carrier family 18 (vesicular acetylcholine), member 3	11.0

Pathways related to pheochromocytoma according to GeneDecks:

(show top 50)    (show all 265)

id	Pathway	Score	Top Affiliating Genes
1	Development_GDNF family signaling41	11.7	RET, RAF1, FRS2, GRB2, MAPK3, MAPK10
2	Development FGFR signaling pathway10	11.5	RAF1, JUN, FRS2, FGF2, GRB2, MAPKAPK2
3	Development Neurotrophin family signaling10	11.1	RAF1, JUN, GRB2, MAPK3, MAPK10, MAPK1
4	Development_HGF signaling pathway41	11.1	RAF1, JUN, CDH1, FOS, GRB2, MAPK3
5	Colorectal cancer20	11.1	BAD, MSH2, FOS, MAPK9, CASP9
6	ILK Signaling36	11.1	KIT, BMP4, UTS2, BAD, JUN, JUNB
7	Immune response Oncostatin M signaling via MAPK in human cells10	11.0	RAF1, JUN, JUNB, MMP1, FOS, FOSL1
8	Development EGFR signaling pathway10	10.9	DUSP4
9	Paxillin Interactions36	10.9	KIT, BMP4, UTS2, FLT1, INSR, FGF1
10	Breast Cancer Regulation by Stathmin136	10.8	BMP4, RAF1, UTS2, FGF1, FGF2, GRB2
11	Ras Pathway36	10.7	KIT, BMP4, RAF1, RALA, UTS2, JUN
12	Mucin expression in CF via TLRs, EGFR signaling pathways41	10.6	RAF1, JUN, JUNB, FOS, FOSL1, FOSL2
13	Apoptosis and survival Role of CDK5 in neuronal death and survival10	10.6	BCL2, BAD, CASP9, CYCS, NTRK1, NGF
14	eIF2 Pathway36	10.5	KIT, BMP4, RAF1, UTS2, INSR, FGF2
15	ERK5 Signaling36	10.5	KIT, MYC, BMP4, UTS2, BAD, FOS
16	JNK Pathway36	10.5	KIT, BMP4, RAF1, UTS2, BCL2, JUN
17	Development_VEGF signaling via VEGFR2 - generic cascades41	10.5	VEGFA, RAF1, JUN, FOS, MAPKAPK2, MAPK3
18	mTOR Pathway36	10.5	BMP4, UTS2, INSR, FGF1, FGF2, IL6
19	ErbB2-ErbB3 Heterodimers36	10.5	RAF1, BAD, GRB2, ERBB2, NRG2, PLCG1
20	PTEN Pathway36	10.5	KIT, BMP4, UTS2, FLT1, FGF1, FGF2
21	cAMP Pathway36	10.5	KIT, GCGR, BMP4, RAF1, UTS2, UCN
22	p70S6K Signaling36	10.4	KIT, BMP4, RAF1, UTS2, BAD, FLT1
23	Activation of PKC through GPCR36	10.3	KIT, BMP4, RAF1, UTS2, FLT1, FGF1
24	eNOS Signaling36	10.2	KIT, UTS2, CHRNA7, INSR, FGF1, CCNA2
25	Akt Signaling36	10.1	KIT, BMP4, RAF1, UTS2, LIF, FGF1
26	Phospholipase-C Pathway36	10.0	KIT, BMP4, RAF1, RALA, UTS2, FLT1
27	14-3-3 Induced Intracellular Signaling36	10.0	BMP4, RAF1, UTS2, BAD, JUN, FLT1
28	Nanog in Mammalian ESC Pluripotency36	9.9	KIT, BMP4, RAF1, UTS2, FLT1, INSR
29	Apoptosis and survival_Role of CDK5 in neuronal death and survival41	9.8	RAF1, BCL2, BAD, JUN, MAPK3, MAPK10
30	PPAR Pathway36	9.7	KIT, BMP4, RAF1, UTS2, FLT1, FGF1
31	Rho Family GTPases36	9.7	KIT, BMP4, RAF1, UTS2, LIF, BCL2
32	Rap1 Pathway36	9.7	BMP4, RAF1, UTS2, INSR, FGF1, FGF2
33	Telomerase Components in Cell Signaling36	9.6	KIT, MYC, BMP4, UTS2, FLT1, FGF1
34	MAPK Family Pathway36	9.4	BMP4, RAF1, UTS2, BCL2, JUN, FLT1
35	Endothelin-1 Signaling Pathway36	9.3	KIT, MYC, BMP4, RAF1, FLT1, INSR
36	p53 Mediated Apoptosis36	9.2	KIT, BMP4, UTS2, BCL2, FLT1, FGF1
37	Apoptotic Pathways in Synovial Fibroblasts36	9.1	KIT, BMP4, UTS2, FLT1, FGF1, FGF2
38	Prostate cancer20	9.1	RAF1, BCL2, BAD, CDK2, CDKN1B, GRB2
39	PAK Pathway36	9.1	KIT, BMP4, UTS2, LIF, BCL2, FLT1
40	ERK Signaling36	9.0	KIT, MYC, BMP4, RAF1, UTS2, FLT1
41	Estrogen Pathway36	9.0	KIT, BMP4, RAF1, UTS2, BCL2, JUN
42	Mitochondrial Apoptosis36	9.0	KIT, BMP4, UTS2, BCL2, BAD, CDKN2A
43	Molecular Mechanisms of Cancer36	9.0	MYC, BMP4, RAF1, UTS2, LIF, BCL2
44	JAK-STAT Pathway36	8.9	KIT, MYC, BMP4, RAF1, RAN, UTS2
45	Antioxidant Action of Vitamin-C36	8.9	KIT, BMP4, UTS2, LIF, BCL2, JUN
46	MAPK Signaling36	8.4	KIT, MYC, BMP4, RAF1, UTS2, BCL2
47	Pancreatic Adenocarcinoma36	8.3	KIT, BMP4, RAF1, UTS2, BIRC5, BCL2
48	p38 Signaling36	8.3	KIT, BMP4, RALA, UTS2, LIF, BCL2
49	Cellular Apoptosis Pathway36	8.2	KIT, BMP4, UTS2, BCL2, BAD, CDKN2A
50	Pathways in cancer20	8.1	RET, VEGFA, MYC, BMP4, RALA, BIRC5

Compounds related to pheochromocytoma according to GeneDecks:

(show top 50)    (show all 486)

id	Compound	Score	Top Affiliating Genes
1	calcium32 9 18 9	18.4	PIK3C2A, REN, REST, KIT, PCSK2, PCSK1
2	forskolin32 42 9 9	17.6	REN, PCSK1, VIP, VIPR1, VGF, BMP4
3	cyclic amp32 18	14.5	RET, PCSK2, GCGR, SETD2, VGF, LIF
4	glucose32	13.5	KIT, PCSK2, PCSK1, GCGR, GCH1, SETD2
5	atp32	13.4	PIK3C2A, NCAM1, RET, KIT, GCGR, SETD2
6	gtp32	13.0	PIK3C2A, GCGR, GCH1, VIP, VIPR1, RAF1
7	nitric oxide32 9 18 9	15.7	NCAM1, REN, KIT, GCH1, VIPR1, VHL
8	cysteine32	12.6	BMP4, RAF1, RAN, UTS2, LIF, SDHB
9	hydrogen32 18	13.4	BNIP3, SCG5, SCT, CHGA, UCP1, BACE1
10	ethanol32 34 9 18 9	16.4	NCAM1, SDHB, SCT, CHKA, CHRNA7, CHAT
11	morphine32 9 9	14.1	VIP, JUNB, MME, MAPK10, HSP90AA1, CACNA1B
12	cgmp32	12.0	REN, PCSK1, GCH1, VIP, JUNB, MME
13	phosphotyrosine32	11.5	RET, KIT, RAF1, SCG5, FRS2, CDK2
14	ionomycin32	11.5	SETD2, JUNB, CDK4, FOS, GRP, MAP2
15	pertussis32	11.4	VIP, JUN, FOS, MAPK10, MAPK1, DYT10
16	bisindolylmaleimide32	11.3	RAF1, S100B, FOS, GRP, MAPK3, PTK2B
17	capsaicin32	11.2	VIP, SCG2, LEP, CDK2, MME, FOS
18	histidine32	11.1	VHL, SCG5, SCT, CHGA, MTR, S100B
19	prostaglandin f2alpha32	11.1	SERPINE1, VIP, RAF1, UCN, MMP1, GRP
20	okadaic acid32 42	11.8	MYC, RAF1, BCL2, BAD, JUN, JUNB
21	arachidonic acid32 9 18 9	13.8	NCAM1, LIF, SCARB1, JUNB, CDH2, CDH1
22	polysaccharide32	10.8	NCAM1, LIF, SCG5, LGALS3, BACE1, CDH2
23	l-nmma32	10.7	VIP, INSR, CAT, GHRL, CRH, NOS2
24	fatty acid32	10.7	PIK3C2A, GCGR, BNIP3, SCARB1, LGALS3, LEP
25	phosphoramidon32 9 9	12.6	VIP, MME, GRP, APP, ANPEP, CALCA
26	dmso32	10.6	SDHB, CHGA, CD36, INSR, MAP2, DUSP19
27	c-peptide32	10.6	PCSK2, PCSK1, SCT, LEP, UCP1, INSR
28	nicotine32 34 9 9	13.6	BIRC5, GRP, CACNA1B, TMPO, PTHLH, CYP2D6
29	bromodeoxyuridine32	10.5	NCAM1, MYC, MYCN, BMP4, CHGA, S100B
30	egcg32	10.3	RAF1, CDK2, APP, MAPK3, MAPK14, MAPK10
31	sodium dodecylsulfate32	10.0	SERPINE1, MYC, RAF1, LGALS3, CDH2, CDH1
32	valine32	10.0	RET, KIT, VIP, RAF1, MTR, S100B
33	cholesterol32 9 18 9	12.9	PIK3C2A, REN, SERPINE1, BSG, UTS2, LIF
34	sp 60012532 42	10.9	MMP1, IL13, MAP3K1, CASP3, TP53, DUSP1
35	trastuzumab32 34 9 9	12.6	KIT, RAF1, BIRC5, CDK2, CDKN1B, CDK4
36	clozapine32 34 9 9	12.6	LEP, CHRNA7, FOS, GHRL, DRD2, NTS
37	azathioprine32 34 9 9	12.5	BMP4, LIF, CDKN2A, CDH1, MMP2, MAP2
38	camptothecin32 42 9 9	12.4	SETD2, MYC, BIRC5, BCL2, JUN, CDK2
39	dihydrotestosterone32 9 18 9	12.1	SETD2, SERPINE1, VIP, LEP, CHKA, CDK2
40	hyaluronic acid32 18	10.1	MYC, CD36, CDH1, MMP1, FGF1, FGF2
41	silymarin32	8.9	VEGFA, BIRC5, JUN, CDK2, CDK4, MMP2
42	arsenite32 18	9.8	SETD2, VEGFA, MYC, BIRC5, BCL2, JUN
43	folate32	8.8	GCH1, VHL, MYC, MTR, CDKN2A, CDH1
44	imatinib32 34 9 9	11.6	RET, KIT, VIP, VEGFA, MYC, RAF1
45	alpha tocopherol32	8.0	LIF, SCARB1, LEP, CHKA, CD36, MMP1
46	indomethacin32 9 9	9.8	REN, VIP, MYC, RAF1, UTS2, BIRC5
47	adriamycin32	7.0	MYC, MYCN, BIRC5, BCL2, CD36, CDKN2A
48	resveratrol32 9 18 9	10.0	BSG, VEGFA, RAF1, BIRC5, BCL2, JUN
49	tamoxifen32 34 9 9	9.9	VEGFA, MYC, RAF1, RALA, BIRC5, BCL2
50	curcumin32	6.0	VEGFA, MYC, RAF1, BIRC5, BCL2, JUN

Cellular components related to pheochromocytoma according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to plasma membrane	GO:005887	11.9	PLAUR, SIGLEC7, ADRB2, ADRA2C, ADORA2A, ADRB3
2	neuronal cell body	GO:043025	11.4	HDC, MBP, MAP2, IAPP, CALCA, DDC
3	endosome	GO:005768	10.8	NTRK1, SNAP25, CRK, PKN1, NGF, NGFR
4	secretory granule	GO:030141	10.7	PCSK2, PCSK1, VEGFA, SCG2, SCG5, CHGB
5	axon	GO:030424	10.6	ADCY10, ADNP, GAP43, CHAT, ADRA2C, ADRB2
6	plasma membrane	GO:005886	10.5	BSG, RAMP2, RAF1, RALA, UTS2R, SCARB1
7	extracellular region	GO:005576	10.2	NPY, CPE, PENK, KNG1, ADM, ADCYAP1
8	cytosol	GO:005829	10.0	TAT, DES, STMN1, PSMC4, PSMC6, PRKAR1A
9	nucleoplasm	GO:005654	10.0	NRBF2, NGFR, NOTCH1, CREB1, NR5A1, SP1
10	cytoplasm	GO:005737	9.8	PDGFRB, EDN1, EGLN3, WNT1, ADRA2C, ACVR2B
11	cell surface	GO:009986	9.6	ACVR2B, ADA, WNT1, TGFA, ACVR1B, PLAUR
12	extracellular space	GO:005615	8.1	LIF, SCG2, LEP, UCN3, MMP2, FLT1

Biological processes related to pheochromocytoma according to GeneDecks:

(show top 50)    (show all 76)

id	Name	GO ID	Score	Top Affiliating Genes
1	synaptic transmission	GO:007268	12.1	VIPR1, RAF1, UTS2, CHRNA7, CHAT, FGF2
2	cell-cell signaling	GO:007267	11.9	PCSK1, MLN, INHA, INHBA, GRB2, IL13
3	neuropeptide signaling pathway	GO:007218	11.7	SCG5, UCN, GRP, CALCA, PDYN, HCRT
4	nerve growth factor receptor signaling pathway	GO:048011	11.7	RAF1, RALA, BAD, FRS2, CDKN1B, GRB2
5	feeding behavior	GO:007631	11.5	CALCA, DRD2, PYY, NTRK2, CRH, HCRTR1
6	negative regulation of blood pressure	GO:045776	11.4	GCH1, UTS2, UTS2R, UCN, CALCA, DRD2
7	small molecule metabolic process	GO:044281	11.3	PIK3C2A, PCSK1, GCGR, GCH1, BSG, SDHA
8	activation of adenylate cyclase activity	GO:007190	11.3	RAF1, GNAS, CALCA, NTRK1, NTRK2, CRHR1
9	activation of MAPKK activity	GO:000186	11.3	BMP4, RAF1, FRS2, NTRK1, CRK, PLCG1
10	response to lipopolysaccharide	GO:032496	11.0	PCSK1, GCH1, JUN, IL13, MAPKAPK2, MAOB
11	toll-like receptor 1 signaling pathway	GO:034130	10.9	JUN, FOS, MAPKAPK2, MAPK3, MAPK14, MAPK10
12	toll-like receptor 2 signaling pathway	GO:034134	10.9	JUN, FOS, MAPKAPK2, MAPK3, MAPK14, MAPK10
13	Ras protein signal transduction	GO:007265	10.8	RAF1, RALA, CDK2, CDKN2A, FGF2, GRB2
14	signal transduction	GO:007165	10.8	RET, KIT, RAF1, RAN, RALA, UTS2R
15	negative regulation of neuron apoptotic process	GO:043524	10.8	BCL2, MSH2, JUN, HTT, NTF3, NTRK1
16	stress-activated MAPK cascade	GO:051403	10.8	JUN, FOS, MAPKAPK2, MAPK3, MAPK14, MAPK10
17	regulation of blood pressure	GO:008217	10.7	REN, GCGR, GCH1, RAMP2, UTS2, LEP
18	fibroblast growth factor receptor signaling pathway	GO:008543	10.7	RAF1, BAD, FRS2, CDKN1B, FGF1, FGF2
19	transmembrane receptor protein tyrosine kinase signaling pathway	GO:007169	10.6	RET, FLT1, ERBB2, NTRK1, NTRK2, NTRK3
20	aging	GO:007568	10.6	JUN, GRB2, IL1B, IGFBP2, CALCA, HMGCR
21	heart development	GO:007507	10.6	RAMP2, RAF1, CASP3, CALCRL, ERBB2, PTEN
22	angiogenesis	GO:001525	10.4	SETD2, SERPINE1, VEGFA, RAMP2, SCG2, JUN
23	positive regulation of angiogenesis	GO:045766	10.4	SERPINE1, VEGFA, RAMP2, UTS2, UTS2R, CHRNA7
24	cell surface receptor signaling pathway	GO:007166	10.3	BSG, CD36, INHA, INHBA, MAPK14, ERBB2
25	female pregnancy	GO:007565	10.3	BCL2, LEP, UCN, FOSL1, FLT1, IGFBP2
26	cellular response to hypoxia	GO:071456	10.2	VHL, VEGFA, BNIP3, BAD, TP53, CUL2
27	response to corticosterone stimulus	GO:051412	10.2	BCL2, UCN3, JUNB, FOSL1, MAOB, CCND1
28	MAPK cascade	GO:000165	10.1	RET, MYC, RAF1, SCG2, MEN1, IL1B
29	positive regulation of MAPK cascade	GO:043410	10.1	KIT, LIF, LEP, CD36, CDH2, FLT1
30	response to estradiol stimulus	GO:032355	10.1	BMP4, UCN, INSR, IL1B, ENO2, IGFBP2
31	epidermal growth factor receptor signaling pathway	GO:007173	10.1	PIK3C2A, RAF1, BAD, CDKN1B, GRB2, MAPK3
32	response to drug	GO:042493	9.8	REN, PCSK1, MYC, UTS2, UTS2R, BCL2
33	response to mechanical stimulus	GO:009612	9.8	BMP4, JUN, JUNB, FOSL1, ANGPT2, IGFBP2
34	positive regulation of cell proliferation	GO:008284	9.8	KIT, VIP, VIPR1, VEGFA, MYC, LIF
35	response to glucocorticoid stimulus	GO:051384	9.7	PCSK1, SERPINE1, UCN, INSR, IL1B, IL6
36	negative regulation of cell proliferation	GO:008285	9.6	REST, VHL, BMP4, RAF1, LIF, JUN
37	positive regulation of apoptotic process	GO:043065	9.6	REST, BMP4, BAD, FOSL1, MEN1, IL1B
38	platelet activation	GO:030168	9.4	SERPINE1, VEGFA, RAF1, CD36, GRB2, IL6
39	activation of MAPK activity	GO:000187	9.4	KIT, CHRNA7, FRS2, INSR, FGF2, IL1B
40	positive regulation of smooth muscle cell proliferation	GO:048661	9.3	BMP4, JUN, FLT1, IL13, IL6, IL6R
41	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.0	VEGFA, LIF, CD36, IL6, IL6R, IGF2
42	positive regulation of transcription, DNA-dependent	GO:045893	9.0	REST, RET, VHL, MYC, BMP4, RAN
43	blood coagulation	GO:007596	9.0	SERPINE1, BSG, VEGFA, RAF1, CDK2, CD36
44	anti-apoptosis	GO:006916	9.0	VHL, BNIP3, BIRC5, BCL2, BAG3, IL1B
45	positive regulation of mitosis	GO:045840	8.9	INSR, IL1B, IGF2, TNF, PDGFRB, EDN1
46	response to hypoxia	GO:001666	8.8	VEGFA, BNIP3, RAF1, UTS2, BCL2, LEP
47	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.7	SERPINE1, VEGFA, MYC, MYCN, BMP4, LIF
48	positive regulation of protein phosphorylation	GO:001934	8.6	VEGFA, BMP4, INSR, FGF1, IL1B, MAPK3
49	apoptotic process	GO:006915	8.4	KIF1B, BNIP3, MZB1, RAF1, BIRC5, BCL2
50	negative regulation of apoptotic process	GO:043066	7.7	SERPINE1, VEGFA, MYC, BMP4, RAF1, BCL2

Molecular functions related to pheochromocytoma according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	neuropeptide hormone activity	GO:005184	11.5	GAL, ADCYAP1, PENK, NPY, PRLH, HCRT
2	receptor binding	GO:005102	11.4	ANGPT2, CRH, NRTN, NRG2, NTF3, SRC
3	hormone activity	GO:005179	11.0	PRLH, PRL, STC1, TTR, EDN3, EDN1
4	protein homodimerization activity	GO:042803	9.7	GDNF, TERT, HMGCR, GJB1, CAT, HSP90AA1
5	growth factor activity	GO:008083	9.7	LIF, NTF3, VGF, NRG2, NGF, EGF
6	protein heterodimerization activity	GO:046982	9.0	ERBB2, TP53, HIF1A, TYR, TWIST1, TOP2A
7	protein binding	GO:005515	8.8	OXA1L, ACP1, ACVR1B, ACVR2A, ACVR2B, ACE
8	enzyme binding	GO:019899	8.5	CAT, ESR1, CBS, CCND1, IL6R, MSH2
9	identical protein binding	GO:042802	7.6	EPOR, MAP3K1, APP, GRB2, INHBA, FLT1