MCID: PHL007
MIFTS: 27

Philadelphia-Negative Chronic Myeloid Leukemia malady

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Summaries for Philadelphia-Negative Chronic Myeloid Leukemia

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33MalaCards
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MalaCards: Philadelphia-Negative Chronic Myeloid Leukemia is related to chronic myeloid leukemia and myeloid leukemia. An important gene associated with Philadelphia-Negative Chronic Myeloid Leukemia is BCR (breakpoint cluster region), and among its related pathways are Pathways in cancer and Tyrosine Kinases / Adaptors. The compounds bosutinib monohydrate and nilotinib have been mentioned in the context of this disorder. Affiliated tissues include myeloid, and related mouse phenotypes are digestive/alimentary and normal.

Aliases & Classifications for Philadelphia-Negative Chronic Myeloid Leukemia

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43NIH Rare Diseases
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

philadelphia-negative chronic myeloid leukemia 43


Related Diseases for Philadelphia-Negative Chronic Myeloid Leukemia

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Philadelphia-Negative Chronic Myeloid Leukemia:



Diseases related to philadelphia-negative chronic myeloid leukemia

Symptoms for Philadelphia-Negative Chronic Myeloid Leukemia

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Drugs & Therapeutics for Philadelphia-Negative Chronic Myeloid Leukemia

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Philadelphia-Negative Chronic Myeloid Leukemia

Search NIH Clinical Center for Philadelphia-Negative Chronic Myeloid Leukemia

Genetic Tests for Philadelphia-Negative Chronic Myeloid Leukemia

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Anatomical Context for Philadelphia-Negative Chronic Myeloid Leukemia

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33MalaCards
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MalaCards organs/tissues related to Philadelphia-Negative Chronic Myeloid Leukemia:

33
Myeloid

Animal Models for Philadelphia-Negative Chronic Myeloid Leukemia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Philadelphia-Negative Chronic Myeloid Leukemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.6BCR, ETV6, ABL1
2MP:00028738.6ABL1, ETV6, BCR
3MP:00053978.5BCR, ETV6, ABL1
4MP:00053788.5BCR, ETV6, ABL1
5MP:00053878.4ABL1, ETV6, BCR
6MP:00053848.2BCR, ETV6, ABL1

Publications for Philadelphia-Negative Chronic Myeloid Leukemia

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52PubMed
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Articles related to Philadelphia-Negative Chronic Myeloid Leukemia:

idTitleAuthorsYear
1
Insertion (12;9)(p13;q34q34): a cryptic rearrangement involving ABL1/ETV6 fusion in a patient with Philadelphia-negative chronic myeloid leukemia. (19480935)
2009
2
3' BCR recombines with IGL locus in BCR-ABL-positive philadelphia-negative chronic myeloid leukemia. (10534772)
1999
3
Insertion of the 5' part of BCR within the ABL gene at 9q34 in a Philadelphia-negative chronic myeloid leukemia. (10526530)
1999
4
A Philadelphia-negative chronic myeloid leukemia with a BCR/ABL fusion gene on chromosome 9. (9809034)
1998
5
Translocation of BCR to chromosome 9 in a Philadelphia-negative chronic myeloid leukemia. (8536245)
1995
6
Translocation t(9;9)(p13;q34) in Philadelphia-negative chronic myeloid leukemia with breakpoint cluster region rearrangement. (2790772)
1989
7
Chromosome 22 breakpoints in variant Philadelphia translocations and Philadelphia-negative chronic myeloid leukemia. (2649233)
1989

Variations for Philadelphia-Negative Chronic Myeloid Leukemia

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Expression for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

Search GEO for disease gene expression data for Philadelphia-Negative Chronic Myeloid Leukemia.

Pathways for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

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50PathCards, 30KEGG, 5Cell Signaling Technology, 51PharmGKB
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Compounds for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

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51PharmGKB, 11DrugBank, 45Novoseek, 24HMDB, 29IUPHAR
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Compounds related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1bosutinib monohydrate519.6BCR, ABL1
2nilotinib51 1110.6ABL1, BCR
3homoharringtonine45 51 1111.6BCR, ABL1
4busulfan45 51 1111.6ABL1, BCR
5ponatinib51 1110.6BCR, ABL1
6dasatinib45 51 1111.6BCR, ABL1
7cytarabine45 51 1111.6BCR, ABL1
8ceramide459.5ABL1, BCR
9dmso459.5BCR, ABL1
10phenylalanine459.4ABL1, BCR
11phosphotyrosine459.3BCR, ABL1
12hydrogen45 2410.3BCR, ABL1
13agar459.2ABL1, ETV6
14phosphoinositide459.2ABL1, BCR
15gtp45 2910.0BCR, ABL1
16imatinib45 51 1110.8BCR, ETV6, ABL1
17tyrosine458.7BCR, ETV6, ABL1

GO Terms for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

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16Gene Ontology
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Biological processes related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor receptor signaling pathwayGO:0480089.3BCR, ABL1
2actin cytoskeleton organizationGO:0300369.3BCR, ABL1
3regulation of cell cycleGO:0517269.2BCR, ABL1
4peptidyl-tyrosine phosphorylationGO:0181089.0BCR, ABL1

Molecular functions related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine kinase activityGO:0047139.3BCR, ABL1

Products for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Philadelphia-Negative Chronic Myeloid Leukemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet