MCID: PHL007
MIFTS: 23

Philadelphia-Negative Chronic Myeloid Leukemia malady

Rare diseases category

Aliases & Classifications for Philadelphia-Negative Chronic Myeloid Leukemia

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Philadelphia-Negative Chronic Myeloid Leukemia, Aliases & Descriptions:

Name: Philadelphia-Negative Chronic Myeloid Leukemia 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Summaries for Philadelphia-Negative Chronic Myeloid Leukemia

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MalaCards based summary: Philadelphia-Negative Chronic Myeloid Leukemia is related to myeloid leukemia and leukemia. An important gene associated with Philadelphia-Negative Chronic Myeloid Leukemia is BCR (breakpoint cluster region), and among its related pathways are Pathways in cancer and Tyrosine Kinases / Adaptors. The compounds bosutinib monohydrate and nilotinib have been mentioned in the context of this disorder. Affiliated tissues include myeloid, and related mouse phenotypes are digestive/alimentary and normal.

Related Diseases for Philadelphia-Negative Chronic Myeloid Leukemia

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Graphical network of diseases related to Philadelphia-Negative Chronic Myeloid Leukemia:



Diseases related to philadelphia-negative chronic myeloid leukemia

Symptoms for Philadelphia-Negative Chronic Myeloid Leukemia

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Drugs & Therapeutics for Philadelphia-Negative Chronic Myeloid Leukemia

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Drug clinical trials:

Search ClinicalTrials for Philadelphia-Negative Chronic Myeloid Leukemia

Search NIH Clinical Center for Philadelphia-Negative Chronic Myeloid Leukemia

Genetic Tests for Philadelphia-Negative Chronic Myeloid Leukemia

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Anatomical Context for Philadelphia-Negative Chronic Myeloid Leukemia

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MalaCards organs/tissues related to Philadelphia-Negative Chronic Myeloid Leukemia:

31
Myeloid

Animal Models for Philadelphia-Negative Chronic Myeloid Leukemia or affiliated genes

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MGI Mouse Phenotypes related to Philadelphia-Negative Chronic Myeloid Leukemia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.6BCR, ETV6, ABL1
2MP:00028738.6ABL1, ETV6, BCR
3MP:00053978.5BCR, ETV6, ABL1
4MP:00053788.5BCR, ETV6, ABL1
5MP:00053878.4ABL1, ETV6, BCR
6MP:00053848.2BCR, ETV6, ABL1

Publications for Philadelphia-Negative Chronic Myeloid Leukemia

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Articles related to Philadelphia-Negative Chronic Myeloid Leukemia:

idTitleAuthorsYear
1
Insertion (12;9)(p13;q34q34): a cryptic rearrangement involving ABL1/ETV6 fusion in a patient with Philadelphia-negative chronic myeloid leukemia. (19480935)
2009
2
3' BCR recombines with IGL locus in BCR-ABL-positive philadelphia-negative chronic myeloid leukemia. (10534772)
1999
3
Insertion of the 5' part of BCR within the ABL gene at 9q34 in a Philadelphia-negative chronic myeloid leukemia. (10526530)
1999
4
A Philadelphia-negative chronic myeloid leukemia with a BCR/ABL fusion gene on chromosome 9. (9809034)
1998
5
Translocation of BCR to chromosome 9 in a Philadelphia-negative chronic myeloid leukemia. (8536245)
1995
6
Translocation t(9;9)(p13;q34) in Philadelphia-negative chronic myeloid leukemia with breakpoint cluster region rearrangement. (2790772)
1989
7
Chromosome 22 breakpoints in variant Philadelphia translocations and Philadelphia-negative chronic myeloid leukemia. (2649233)
1989

Variations for Philadelphia-Negative Chronic Myeloid Leukemia

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Expression for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

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Search GEO for disease gene expression data for Philadelphia-Negative Chronic Myeloid Leukemia.

Pathways for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

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Compounds for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

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Sources:
49PharmGKB, 12DrugBank, 43Novoseek, 24HMDB, 28IUPHAR
See all sources

Compounds related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards Suite gene sharing:

(show all 17)
idCompoundScoreTop Affiliating Genes
1bosutinib monohydrate499.6BCR, ABL1
2nilotinib49 1210.6ABL1, BCR
3homoharringtonine43 49 1211.6BCR, ABL1
4busulfan43 49 1211.6ABL1, BCR
5ponatinib49 1210.6BCR, ABL1
6dasatinib43 49 1211.6BCR, ABL1
7cytarabine43 49 1211.6BCR, ABL1
8ceramide439.5ABL1, BCR
9dmso439.5BCR, ABL1
10phenylalanine439.4ABL1, BCR
11phosphotyrosine439.3BCR, ABL1
12hydrogen43 2410.3BCR, ABL1
13agar439.2ABL1, ETV6
14phosphoinositide439.2ABL1, BCR
15gtp43 2810.0BCR, ABL1
16imatinib43 49 1210.8BCR, ETV6, ABL1
17tyrosine438.7BCR, ETV6, ABL1

GO Terms for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

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Biological processes related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor receptor signaling pathwayGO:00480089.3BCR, ABL1
2actin cytoskeleton organizationGO:00300369.3BCR, ABL1
3regulation of cell cycleGO:00517269.2BCR, ABL1
4peptidyl-tyrosine phosphorylationGO:00181089.0BCR, ABL1

Molecular functions related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine kinase activityGO:00047139.3BCR, ABL1

Products for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Philadelphia-Negative Chronic Myeloid Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet