MCID: PHL007
MIFTS: 27

Philadelphia-Negative Chronic Myeloid Leukemia malady

Rare diseases category
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Summaries for Philadelphia-Negative Chronic Myeloid Leukemia

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MalaCards based summary: Philadelphia-Negative Chronic Myeloid Leukemia is related to pdgfrb-associated chronic eosinophilic leukemia and chronic myeloid leukemia. An important gene associated with Philadelphia-Negative Chronic Myeloid Leukemia is BCR (breakpoint cluster region), and among its related pathways are Pathways in cancer and Tyrosine Kinases / Adaptors. The compounds bosutinib monohydrate and nilotinib have been mentioned in the context of this disorder. Affiliated tissues include myeloid, and related mouse phenotypes are digestive/alimentary and normal.

Aliases & Classifications for Philadelphia-Negative Chronic Myeloid Leukemia

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Philadelphia-Negative Chronic Myeloid Leukemia, Aliases & Descriptions:

Name: Philadelphia-Negative Chronic Myeloid Leukemia 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Philadelphia-Negative Chronic Myeloid Leukemia

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Graphical network of diseases related to Philadelphia-Negative Chronic Myeloid Leukemia:



Diseases related to philadelphia-negative chronic myeloid leukemia

Symptoms for Philadelphia-Negative Chronic Myeloid Leukemia

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Drugs & Therapeutics for Philadelphia-Negative Chronic Myeloid Leukemia

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Drug clinical trials:

Search ClinicalTrials for Philadelphia-Negative Chronic Myeloid Leukemia

Search NIH Clinical Center for Philadelphia-Negative Chronic Myeloid Leukemia

Genetic Tests for Philadelphia-Negative Chronic Myeloid Leukemia

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Anatomical Context for Philadelphia-Negative Chronic Myeloid Leukemia

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MalaCards organs/tissues related to Philadelphia-Negative Chronic Myeloid Leukemia:

32
Myeloid

Animal Models for Philadelphia-Negative Chronic Myeloid Leukemia or affiliated genes

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MGI Mouse Phenotypes related to Philadelphia-Negative Chronic Myeloid Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.6BCR, ETV6, ABL1
2MP:00028738.6BCR, ABL1, ETV6
3MP:00053978.5ETV6, BCR, ABL1
4MP:00053788.5ABL1, ETV6, BCR
5MP:00053878.4BCR, ETV6, ABL1
6MP:00053848.2ABL1, ETV6, BCR

Publications for Philadelphia-Negative Chronic Myeloid Leukemia

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Articles related to Philadelphia-Negative Chronic Myeloid Leukemia:

idTitleAuthorsYear
1
Insertion (12;9)(p13;q34q34): a cryptic rearrangement involving ABL1/ETV6 fusion in a patient with Philadelphia-negative chronic myeloid leukemia. (19480935)
2009
2
3' BCR recombines with IGL locus in BCR-ABL-positive philadelphia-negative chronic myeloid leukemia. (10534772)
1999
3
Insertion of the 5' part of BCR within the ABL gene at 9q34 in a Philadelphia-negative chronic myeloid leukemia. (10526530)
1999
4
A Philadelphia-negative chronic myeloid leukemia with a BCR/ABL fusion gene on chromosome 9. (9809034)
1998
5
Translocation of BCR to chromosome 9 in a Philadelphia-negative chronic myeloid leukemia. (8536245)
1995
6
Translocation t(9;9)(p13;q34) in Philadelphia-negative chronic myeloid leukemia with breakpoint cluster region rearrangement. (2790772)
1989
7
Chromosome 22 breakpoints in variant Philadelphia translocations and Philadelphia-negative chronic myeloid leukemia. (2649233)
1989

Variations for Philadelphia-Negative Chronic Myeloid Leukemia

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Expression for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

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Expression patterns in normal tissues for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

Search GEO for disease gene expression data for Philadelphia-Negative Chronic Myeloid Leukemia.

Pathways for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

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Compounds for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

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Sources:
50PharmGKB, 11DrugBank, 44Novoseek, 24HMDB, 28IUPHAR
See all sources

Compounds related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1bosutinib monohydrate509.6ABL1, BCR
2nilotinib50 1110.6ABL1, BCR
3homoharringtonine44 50 1111.6ABL1, BCR
4busulfan44 50 1111.6BCR, ABL1
5ponatinib50 1110.6ABL1, BCR
6dasatinib44 50 1111.6ABL1, BCR
7cytarabine44 50 1111.6ABL1, BCR
8ceramide449.5ABL1, BCR
9dmso449.5ABL1, BCR
10phenylalanine449.4BCR, ABL1
11phosphotyrosine449.3BCR, ABL1
12hydrogen44 2410.3BCR, ABL1
13phosphoinositide449.2ABL1, BCR
14agar449.2ABL1, ETV6
15gtp44 2810.0ABL1, BCR
16imatinib44 50 1110.8BCR, ETV6, ABL1
17tyrosine448.7BCR, ETV6, ABL1

GO Terms for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

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Biological processes related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor receptor signaling pathwayGO:0480089.3BCR, ABL1
2actin cytoskeleton organizationGO:0300369.3BCR, ABL1
3regulation of cell cycleGO:0517269.2BCR, ABL1
4peptidyl-tyrosine phosphorylationGO:0181089.0BCR, ABL1

Molecular functions related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine kinase activityGO:0047139.3BCR, ABL1

Products for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

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  • Antibodies
  • Proteins
  • Lysates

Sources for Philadelphia-Negative Chronic Myeloid Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet