MCID: PHL007
MIFTS: 27

Philadelphia-Negative Chronic Myeloid Leukemia malady

Rare diseases category

Summaries for Philadelphia-Negative Chronic Myeloid Leukemia

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34MalaCards
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MalaCards: Philadelphia-Negative Chronic Myeloid Leukemia is related to chronic myeloid leukemia and myeloid leukemia. An important gene associated with Philadelphia-Negative Chronic Myeloid Leukemia is BCR (breakpoint cluster region), and among its related pathways are Pathways in cancer and Tyrosine Kinases / Adaptors. The compounds bosutinib monohydrate and nilotinib have been mentioned in the context of this disorder. Affiliated tissues include myeloid, and related mouse phenotypes are digestive/alimentary and normal.

Aliases & Classifications for Philadelphia-Negative Chronic Myeloid Leukemia

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44NIH Rare Diseases
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

philadelphia-negative chronic myeloid leukemia 44


Related Diseases for Philadelphia-Negative Chronic Myeloid Leukemia

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18GeneCards, 19GeneDecks
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Graphical network of diseases related to Philadelphia-Negative Chronic Myeloid Leukemia:



Diseases related to philadelphia-negative chronic myeloid leukemia

Symptoms for Philadelphia-Negative Chronic Myeloid Leukemia

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Drugs & Therapeutics for Philadelphia-Negative Chronic Myeloid Leukemia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Philadelphia-Negative Chronic Myeloid Leukemia

Drug clinical trials:

Search ClinicalTrials for Philadelphia-Negative Chronic Myeloid Leukemia

Search NIH Clinical Center for Philadelphia-Negative Chronic Myeloid Leukemia

Search CenterWatch for Philadelphia-Negative Chronic Myeloid Leukemia

Genetic Tests for Philadelphia-Negative Chronic Myeloid Leukemia

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Anatomical Context for Philadelphia-Negative Chronic Myeloid Leukemia

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34MalaCards
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MalaCards organs/tissues related to Philadelphia-Negative Chronic Myeloid Leukemia:

34
Myeloid

Animal Models for Philadelphia-Negative Chronic Myeloid Leukemia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Philadelphia-Negative Chronic Myeloid Leukemia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.6BCR, ETV6, ABL1
2MP:00028738.6ABL1, ETV6, BCR
3MP:00053978.5BCR, ETV6, ABL1
4MP:00053788.5BCR, ETV6, ABL1
5MP:00053878.4ABL1, ETV6, BCR
6MP:00053848.2BCR, ETV6, ABL1

Publications for Philadelphia-Negative Chronic Myeloid Leukemia

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53PubMed
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Articles related to Philadelphia-Negative Chronic Myeloid Leukemia:

idTitleAuthorsYear
1
Insertion (12;9)(p13;q34q34): a cryptic rearrangement involving ABL1/ETV6 fusion in a patient with Philadelphia-negative chronic myeloid leukemia. (19480935)
2009
2
3' BCR recombines with IGL locus in BCR-ABL-positive philadelphia-negative chronic myeloid leukemia. (10534772)
1999
3
Insertion of the 5' part of BCR within the ABL gene at 9q34 in a Philadelphia-negative chronic myeloid leukemia. (10526530)
1999
4
A Philadelphia-negative chronic myeloid leukemia with a BCR/ABL fusion gene on chromosome 9. (9809034)
1998
5
Translocation of BCR to chromosome 9 in a Philadelphia-negative chronic myeloid leukemia. (8536245)
1995
6
Translocation t(9;9)(p13;q34) in Philadelphia-negative chronic myeloid leukemia with breakpoint cluster region rearrangement. (2790772)
1989
7
Chromosome 22 breakpoints in variant Philadelphia translocations and Philadelphia-negative chronic myeloid leukemia. (2649233)
1989

Variations for Philadelphia-Negative Chronic Myeloid Leukemia

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Expression for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

Search GEO for disease gene expression data for Philadelphia-Negative Chronic Myeloid Leukemia.

Pathways for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

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Sources:
51PathCards, 31KEGG, 5Cell Signaling Technology, 52PharmGKB
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Compounds for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

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Sources:
52PharmGKB, 12DrugBank, 46Novoseek, 25HMDB, 30IUPHAR
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Compounds related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1bosutinib monohydrate529.6BCR, ABL1
2nilotinib52 1210.6ABL1, BCR
3homoharringtonine46 52 1211.6BCR, ABL1
4busulfan46 52 1211.6ABL1, BCR
5ponatinib52 1210.6BCR, ABL1
6dasatinib46 52 1211.6BCR, ABL1
7cytarabine46 52 1211.6BCR, ABL1
8ceramide469.5ABL1, BCR
9dmso469.5BCR, ABL1
10phenylalanine469.4ABL1, BCR
11phosphotyrosine469.3BCR, ABL1
12hydrogen46 2510.3BCR, ABL1
13agar469.2ABL1, ETV6
14phosphoinositide469.2ABL1, BCR
15gtp46 3010.0BCR, ABL1
16imatinib46 52 1210.8BCR, ETV6, ABL1
17tyrosine468.7BCR, ETV6, ABL1

GO Terms for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

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17Gene Ontology
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Biological processes related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor receptor signaling pathwayGO:0480089.3BCR, ABL1
2actin cytoskeleton organizationGO:0300369.3BCR, ABL1
3regulation of cell cycleGO:0517269.2BCR, ABL1
4peptidyl-tyrosine phosphorylationGO:0181089.0BCR, ABL1

Molecular functions related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine kinase activityGO:0047139.3BCR, ABL1

Products for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Philadelphia-Negative Chronic Myeloid Leukemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet