MCID: PHL007
MIFTS: 19

Philadelphia-Negative Chronic Myeloid Leukemia malady

Summaries for Philadelphia-Negative Chronic Myeloid Leukemia

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32MalaCards
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MalaCards: Philadelphia-Negative Chronic Myeloid Leukemia is related to chronic myeloid leukemia and myeloid leukemia. An important gene associated with Philadelphia-Negative Chronic Myeloid Leukemia is BCR (breakpoint cluster region), and among its related pathways are Pathways in cancer and Tyrosine Kinases / Adaptors. The compounds dasatinib and cytarabine have been mentioned in the context of this disorder. Affiliated tissues include myeloid, and related mouse phenotypes are hematopoietic system and digestive/alimentary.

Aliases & Classifications for Philadelphia-Negative Chronic Myeloid Leukemia

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42NIH Rare Diseases
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Aliases & Descriptions:

philadelphia-negative chronic myeloid leukemia 42


Related Diseases for Philadelphia-Negative Chronic Myeloid Leukemia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Philadelphia-Negative Chronic Myeloid Leukemia:



Diseases related to philadelphia-negative chronic myeloid leukemia

Clinical Features for Philadelphia-Negative Chronic Myeloid Leukemia

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Drugs & Therapeutics for Philadelphia-Negative Chronic Myeloid Leukemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Philadelphia-Negative Chronic Myeloid Leukemia

Drug clinical trials:

Search ClinicalTrials for Philadelphia-Negative Chronic Myeloid Leukemia

Search NIH Clinical Center for Philadelphia-Negative Chronic Myeloid Leukemia

Search CenterWatch for Philadelphia-Negative Chronic Myeloid Leukemia

Genetic Tests for Philadelphia-Negative Chronic Myeloid Leukemia

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Anatomical Context for Philadelphia-Negative Chronic Myeloid Leukemia

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32MalaCards
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MalaCards organs/tissues related to Philadelphia-Negative Chronic Myeloid Leukemia:

32
Myeloid

Animal Models for Philadelphia-Negative Chronic Myeloid Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Philadelphia-Negative Chronic Myeloid Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.5BCR, ABL1, ETV6
2MP:00053818.2BCR, ABL1, ETV6

Publications for Philadelphia-Negative Chronic Myeloid Leukemia

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Genetic Variations for Philadelphia-Negative Chronic Myeloid Leukemia

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Expression for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

Search GEO for disease gene expression data for Philadelphia-Negative Chronic Myeloid Leukemia.

Pathways for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

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29KEGG, 4Cell Signaling Technology
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Pathways related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0BCR, ABL1
29.0BCR, ABL1
39.0BCR, ABL1

Compounds for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

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44Novoseek, 49PharmGKB, 11DrugBank
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Compounds related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1dasatinib44 49 1111.2BCR, ABL1
2cytarabine44 49 1111.2ABL1, BCR
3ceramide449.1BCR, ABL1
4agar449.1ABL1, ETV6
5dmso449.1ABL1, BCR
6phosphotyrosine449.0BCR, ABL1
7phenylalanine448.9BCR, ABL1
8imatinib44 49 1110.7BCR, ABL1, ETV6
9tyrosine448.2ETV6, ABL1, BCR

GO Terms for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

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16Gene Ontology
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Biological processes related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1actin cytoskeleton organizationGO:0300369.0BCR, ABL1
2platelet-derived growth factor receptor signaling pathwayGO:0480088.9BCR, ABL1
3regulation of cell cycleGO:0517268.7BCR, ABL1

Molecular functions related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine kinase activityGO:0047139.0BCR, ABL1

Products for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Philadelphia-Negative Chronic Myeloid Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet