MCID: PHL007
MIFTS: 23

Philadelphia-Negative Chronic Myeloid Leukemia

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Philadelphia-Negative Chronic Myeloid Leukemia

MalaCards integrated aliases for Philadelphia-Negative Chronic Myeloid Leukemia:

Name: Philadelphia-Negative Chronic Myeloid Leukemia 50

Classifications:



Summaries for Philadelphia-Negative Chronic Myeloid Leukemia

MalaCards based summary : Philadelphia-Negative Chronic Myeloid Leukemia is related to pdgfrb-associated chronic eosinophilic leukemia and leukemia. An important gene associated with Philadelphia-Negative Chronic Myeloid Leukemia is BCR (BCR, RhoGEF And GTPase Activating Protein), and among its related pathways/superpathways are Pathways in cancer and Tyrosine Kinases / Adaptors. The drugs Busulfan and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include myeloid, and related phenotype is Increased shRNA abundance (Z-score > 2).

Related Diseases for Philadelphia-Negative Chronic Myeloid Leukemia

Graphical network of the top 20 diseases related to Philadelphia-Negative Chronic Myeloid Leukemia:



Diseases related to Philadelphia-Negative Chronic Myeloid Leukemia

Symptoms & Phenotypes for Philadelphia-Negative Chronic Myeloid Leukemia

GenomeRNAi Phenotypes related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.14 ABL1 BCR
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.14 ABL1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.14 BCR
4 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.14 BCR
5 Increased shRNA abundance (Z-score > 2) GR00366-A-123 10.14 ABL1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.14 BCR
7 Increased shRNA abundance (Z-score > 2) GR00366-A-151 10.14 ABL1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-157 10.14 ABL1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10.14 BCR
10 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.14 BCR
11 Increased shRNA abundance (Z-score > 2) GR00366-A-2 10.14 BCR
12 Increased shRNA abundance (Z-score > 2) GR00366-A-215 10.14 BCR
13 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.14 BCR
14 Increased shRNA abundance (Z-score > 2) GR00366-A-3 10.14 ABL1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.14 ABL1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.14 ABL1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.14 ABL1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-83 10.14 ABL1 BCR
19 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.14 ABL1 BCR
20 Decreased viability GR00055-A-2 9.85 BCR
21 Decreased viability GR00221-A-1 9.85 ABL1
22 Decreased viability GR00221-A-2 9.85 ABL1 BCR
23 Decreased viability GR00221-A-3 9.85 ABL1
24 Decreased viability GR00221-A-4 9.85 BCR
25 Decreased viability GR00301-A 9.85 BCR
26 Decreased viability GR00342-S-1 9.85 ABL1
27 Decreased viability GR00342-S-2 9.85 ABL1
28 Decreased viability GR00342-S-3 9.85 ABL1
29 Decreased cell migration GR00055-A-1 9.26 ABL1 BCR
30 Increased circadian period length GR00213-A 8.96 ABL1 BCR

Drugs & Therapeutics for Philadelphia-Negative Chronic Myeloid Leukemia

Drugs for Philadelphia-Negative Chronic Myeloid Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Busulfan Approved, Investigational Phase 1, Phase 2 55-98-1 2478
2
Cyclophosphamide Approved, Investigational Phase 1, Phase 2 50-18-0, 6055-19-2 2907
3
Fludarabine Approved Phase 1, Phase 2 21679-14-1, 75607-67-9 30751
4
Vidarabine Approved Phase 1, Phase 2 24356-66-9 32326 21704
5 Alkylating Agents Phase 1, Phase 2
6 Anti-Infective Agents Phase 1, Phase 2
7 Antimetabolites Phase 1, Phase 2
8 Antimetabolites, Antineoplastic Phase 1, Phase 2
9 Antirheumatic Agents Phase 1, Phase 2
10 Antiviral Agents Phase 1, Phase 2
11 Immunosuppressive Agents Phase 1, Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Allo BMT Using Matched Related/Unrelated Donors With FluBu and HiCY Completed NCT00809276 Phase 1, Phase 2 Busulfan, Fludarabine, Cytoxan

Search NIH Clinical Center for Philadelphia-Negative Chronic Myeloid Leukemia

Genetic Tests for Philadelphia-Negative Chronic Myeloid Leukemia

Anatomical Context for Philadelphia-Negative Chronic Myeloid Leukemia

MalaCards organs/tissues related to Philadelphia-Negative Chronic Myeloid Leukemia:

39
Myeloid

Publications for Philadelphia-Negative Chronic Myeloid Leukemia

Articles related to Philadelphia-Negative Chronic Myeloid Leukemia:

id Title Authors Year
1
Insertion (12;9)(p13;q34q34): a cryptic rearrangement involving ABL1/ETV6 fusion in a patient with Philadelphia-negative chronic myeloid leukemia. ( 19480935 )
2009
2
3' BCR recombines with IGL locus in BCR-ABL-positive philadelphia-negative chronic myeloid leukemia. ( 10534772 )
1999
3
Insertion of the 5' part of BCR within the ABL gene at 9q34 in a Philadelphia-negative chronic myeloid leukemia. ( 10526530 )
1999
4
A Philadelphia-negative chronic myeloid leukemia with a BCR/ABL fusion gene on chromosome 9. ( 9809034 )
1998
5
Translocation of BCR to chromosome 9 in a Philadelphia-negative chronic myeloid leukemia. ( 8536245 )
1995
6
Translocation t(9;9)(p13;q34) in Philadelphia-negative chronic myeloid leukemia with breakpoint cluster region rearrangement. ( 2790772 )
1989
7
Chromosome 22 breakpoints in variant Philadelphia translocations and Philadelphia-negative chronic myeloid leukemia. ( 2649233 )
1989

Variations for Philadelphia-Negative Chronic Myeloid Leukemia

Expression for Philadelphia-Negative Chronic Myeloid Leukemia

Search GEO for disease gene expression data for Philadelphia-Negative Chronic Myeloid Leukemia.

Pathways for Philadelphia-Negative Chronic Myeloid Leukemia

GO Terms for Philadelphia-Negative Chronic Myeloid Leukemia

Cellular components related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein complex GO:0043234 8.62 ABL1 BCR

Biological processes related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein phosphorylation GO:0006468 9.43 ABL1 BCR
2 protein autophosphorylation GO:0046777 9.4 ABL1 BCR
3 peptidyl-tyrosine phosphorylation GO:0018108 9.37 ABL1 BCR
4 actin cytoskeleton organization GO:0030036 9.32 ABL1 BCR
5 regulation of cell cycle GO:0051726 9.26 ABL1 BCR
6 cellular response to lipopolysaccharide GO:0071222 9.16 ABL1 BCR
7 neuromuscular process controlling balance GO:0050885 8.96 ABL1 BCR
8 platelet-derived growth factor receptor signaling pathway GO:0048008 8.62 ABL1 BCR

Molecular functions related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 8.62 ABL1 BCR

Sources for Philadelphia-Negative Chronic Myeloid Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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