MCID: PHL007
MIFTS: 27

Philadelphia-Negative Chronic Myeloid Leukemia malady

Rare diseases category

Summaries for Philadelphia-Negative Chronic Myeloid Leukemia

About this section


MalaCards based summary: Philadelphia-Negative Chronic Myeloid Leukemia is related to pdgfrb-associated chronic eosinophilic leukemia and chronic myeloid leukemia. An important gene associated with Philadelphia-Negative Chronic Myeloid Leukemia is BCR (breakpoint cluster region), and among its related pathways are Pathways in cancer and Tyrosine Kinases / Adaptors. The compounds bosutinib monohydrate and nilotinib have been mentioned in the context of this disorder. Affiliated tissues include myeloid, and related mouse phenotypes are digestive/alimentary and normal.

Aliases & Classifications for Philadelphia-Negative Chronic Myeloid Leukemia

About this section

Philadelphia-Negative Chronic Myeloid Leukemia, Aliases & Descriptions:

Name: Philadelphia-Negative Chronic Myeloid Leukemia 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Philadelphia-Negative Chronic Myeloid Leukemia

About this section

Graphical network of diseases related to Philadelphia-Negative Chronic Myeloid Leukemia:



Diseases related to philadelphia-negative chronic myeloid leukemia

Symptoms for Philadelphia-Negative Chronic Myeloid Leukemia

About this section

Drugs & Therapeutics for Philadelphia-Negative Chronic Myeloid Leukemia

About this section

Drug clinical trials:

Search ClinicalTrials for Philadelphia-Negative Chronic Myeloid Leukemia

Search NIH Clinical Center for Philadelphia-Negative Chronic Myeloid Leukemia

Genetic Tests for Philadelphia-Negative Chronic Myeloid Leukemia

About this section

Anatomical Context for Philadelphia-Negative Chronic Myeloid Leukemia

About this section

MalaCards organs/tissues related to Philadelphia-Negative Chronic Myeloid Leukemia:

32
Myeloid

Animal Models for Philadelphia-Negative Chronic Myeloid Leukemia or affiliated genes

About this section

MGI Mouse Phenotypes related to Philadelphia-Negative Chronic Myeloid Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.6BCR, ETV6, ABL1
2MP:00028738.6ABL1, ETV6, BCR
3MP:00053978.5BCR, ETV6, ABL1
4MP:00053788.5BCR, ETV6, ABL1
5MP:00053878.4ABL1, ETV6, BCR
6MP:00053848.2BCR, ETV6, ABL1

Publications for Philadelphia-Negative Chronic Myeloid Leukemia

About this section

Articles related to Philadelphia-Negative Chronic Myeloid Leukemia:

idTitleAuthorsYear
1
Insertion (12;9)(p13;q34q34): a cryptic rearrangement involving ABL1/ETV6 fusion in a patient with Philadelphia-negative chronic myeloid leukemia. (19480935)
2009
2
3' BCR recombines with IGL locus in BCR-ABL-positive philadelphia-negative chronic myeloid leukemia. (10534772)
1999
3
Insertion of the 5' part of BCR within the ABL gene at 9q34 in a Philadelphia-negative chronic myeloid leukemia. (10526530)
1999
4
A Philadelphia-negative chronic myeloid leukemia with a BCR/ABL fusion gene on chromosome 9. (9809034)
1998
5
Translocation of BCR to chromosome 9 in a Philadelphia-negative chronic myeloid leukemia. (8536245)
1995
6
Translocation t(9;9)(p13;q34) in Philadelphia-negative chronic myeloid leukemia with breakpoint cluster region rearrangement. (2790772)
1989
7
Chromosome 22 breakpoints in variant Philadelphia translocations and Philadelphia-negative chronic myeloid leukemia. (2649233)
1989

Variations for Philadelphia-Negative Chronic Myeloid Leukemia

About this section

Expression for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

About this section
Expression patterns in normal tissues for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

Search GEO for disease gene expression data for Philadelphia-Negative Chronic Myeloid Leukemia.

Pathways for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

About this section

Compounds for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

About this section
Sources:
50PharmGKB, 12DrugBank, 44Novoseek, 25HMDB, 29IUPHAR
See all sources

Compounds related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1bosutinib monohydrate509.6BCR, ABL1
2nilotinib50 1210.6ABL1, BCR
3homoharringtonine44 50 1211.6BCR, ABL1
4busulfan44 50 1211.6ABL1, BCR
5ponatinib50 1210.6BCR, ABL1
6dasatinib44 50 1211.6BCR, ABL1
7cytarabine44 50 1211.6BCR, ABL1
8ceramide449.5ABL1, BCR
9dmso449.5BCR, ABL1
10phenylalanine449.4ABL1, BCR
11phosphotyrosine449.3BCR, ABL1
12hydrogen44 2510.3BCR, ABL1
13agar449.2ABL1, ETV6
14phosphoinositide449.2ABL1, BCR
15gtp44 2910.0BCR, ABL1
16imatinib44 50 1210.8BCR, ETV6, ABL1
17tyrosine448.7BCR, ETV6, ABL1

GO Terms for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

About this section

Biological processes related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor receptor signaling pathwayGO:0480089.3BCR, ABL1
2actin cytoskeleton organizationGO:0300369.3BCR, ABL1
3regulation of cell cycleGO:0517269.2BCR, ABL1
4peptidyl-tyrosine phosphorylationGO:0181089.0BCR, ABL1

Molecular functions related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine kinase activityGO:0047139.3BCR, ABL1

Products for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Philadelphia-Negative Chronic Myeloid Leukemia

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet