MCID: PHL007
MIFTS: 23

Philadelphia-Negative Chronic Myeloid Leukemia malady

Summaries for Philadelphia-Negative Chronic Myeloid Leukemia

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MalaCards: Philadelphia-Negative Chronic Myeloid Leukemia is related to chronic myeloid leukemia and pdgfrb-associated chronic eosinophilic leukemia. An important gene associated with Philadelphia-Negative Chronic Myeloid Leukemia is BCR (breakpoint cluster region), and among its related pathways are Pathways in cancer and Tyrosine Kinases / Adaptors. The compounds dasatinib and cytarabine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, myeloid and t cells, and related mouse phenotypes are hematopoietic system and digestive/alimentary.

Aliases & Classifications for Philadelphia-Negative Chronic Myeloid Leukemia

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43NIH Rare Diseases
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Aliases & Descriptions:

philadelphia-negative chronic myeloid leukemia 43


Related Diseases for Philadelphia-Negative Chronic Myeloid Leukemia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Philadelphia-Negative Chronic Myeloid Leukemia:



Diseases related to philadelphia-negative chronic myeloid leukemia

Clinical Features for Philadelphia-Negative Chronic Myeloid Leukemia

Drugs & Therapeutics for Philadelphia-Negative Chronic Myeloid Leukemia

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Philadelphia-Negative Chronic Myeloid Leukemia

Drug clinical trials:

Search ClinicalTrials for Philadelphia-Negative Chronic Myeloid Leukemia

Search NIH Clinical Center for Philadelphia-Negative Chronic Myeloid Leukemia

Search CenterWatch for Philadelphia-Negative Chronic Myeloid Leukemia

Genetic Tests for Philadelphia-Negative Chronic Myeloid Leukemia

Anatomical Context for Philadelphia-Negative Chronic Myeloid Leukemia

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33MalaCards
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MalaCards organs/tissues related to Philadelphia-Negative Chronic Myeloid Leukemia:

33
Bone marrow, Myeloid, T cells

Animal Models for Philadelphia-Negative Chronic Myeloid Leukemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Philadelphia-Negative Chronic Myeloid Leukemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.5BCR, ABL1, ETV6
2MP:00053818.2BCR, ABL1, ETV6

Publications for Philadelphia-Negative Chronic Myeloid Leukemia

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51PubMed
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Articles related to Philadelphia-Negative Chronic Myeloid Leukemia:

(show all 23)
idTitleAuthorsYear
1
Clonal chromosomal abnormalities in Philadelphia-negative cells in chronic myeloid leukemia patients treated with nilotinib used in first-line therapy. (23793947)
2013
2
Telomere loss in Philadelphia-negative hematopoiesis after successful treatment of chronic myeloid leukemia: evidence for premature aging of the myeloid compartment. (22687638)
2012
3
Philadelphia-negative acute promyelocytic leukemia in a patient with chronic myeloid leukemia in complete cytogenetic response after treatment with tyrosine kinase inhibitor. (22543830)
2012
4
Patients with chronic myeloid leukemia treated with imatinib who showed the appearance of clonal cytogenetic abnormalities in Philadelphia chromosome-negative cells. (22829081)
2011
5
Genetic analysis of dasatinib-treated chronic myeloid leukemia rapidly developing into acute myeloid leukemia with monosomy 7 in Philadelphia-negative cells. (20471511)
2010
6
Insertion (12;9)(p13;q34q34): a cryptic rearrangement involving ABL1/ETV6 fusion in a patient with Philadelphia-negative chronic myeloid leukemia. (19480935)
2009
7
Philadelphia-negative clonal hematopoiesis following imatinib therapy in patients with chronic myeloid leukemia: a report of nine cases and analysis of predictive factors. (16965950)
2006
8
Clonal cytogenetic abnormalities in Philadelphia chromosome negative cells in chronic myeloid leukemia patients treated with imatinib. (15512807)
2004
9
Fluorescent in situ hybridization analysis of Philadelphia chromosome-negative chronic myeloid leukemia with the bcr/abl fusion gene. (15481444)
2004
10
Philadelphia negative, Bcr-Abl positive chronic myeloid leukemia associated with pure red cell aplasia. (12866588)
2003
11
3' BCR recombines with IGL locus in BCR-ABL-positive philadelphia-negative chronic myeloid leukemia. (10534772)
1999
12
Insertion of the 5' part of BCR within the ABL gene at 9q34 in a Philadelphia-negative chronic myeloid leukemia. (10526530)
1999
13
Philadelphia chromosome-negative engraftment after autologous transplantation with granulocyte-macrophage colony-stimulating factor for chronic myeloid leukemia. (10595817)
1999
14
A Philadelphia-negative chronic myeloid leukemia with a BCR/ABL fusion gene on chromosome 9. (9809034)
1998
15
Expansion of Philadelphia chromosome-negative CD3(+)CD56(+) cytotoxic cells from chronic myeloid leukemia patients: in vitro and in vivo efficacy in severe combined immunodeficiency disease mice. (9787169)
1998
16
High-dose hydroxyurea and G-CSF to collect Philadelphia-negative cells in chronic myeloid leukemia: preliminary results. (9021692)
1996
17
Translocation of BCR to chromosome 9 in a Philadelphia-negative chronic myeloid leukemia. (8536245)
1995
18
The detection of Philadelphia chromosome negative metaphases in long-term bone marrow cultures of the peripheral blood from patients with chronic myeloid leukemia predicts response to interferon-alpha 2a. (1453769)
1992
19
Prolonged remission of accelerated phase Philadelphia chromosome negative chronic myeloid leukemia following autologous recovery of normal hematopoietic elements after busulfan/cyclophosphamide and allogeneic marrow transplantation. (1349249)
1992
20
Philadelphia-negative (Ph-) chronic myeloid leukemia (CML): comparison with Ph+ CML and chronic myelomonocytic leukemia. The Groupe FranAsais de CytogAcnActique HAcmatologique. (2070054)
1991
21
Philadelphia chromosome-negative chronic myelogenous leukemia without breakpoint cluster region rearrangement: a chronic myeloid leukemia with a distinct clinical course. (2403827)
1990
22
Translocation t(9;9)(p13;q34) in Philadelphia-negative chronic myeloid leukemia with breakpoint cluster region rearrangement. (2790772)
1989
23
Chromosome 22 breakpoints in variant Philadelphia translocations and Philadelphia-negative chronic myeloid leukemia. (2649233)
1989

Genetic Variations for Philadelphia-Negative Chronic Myeloid Leukemia

Expression for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

Search GEO for disease gene expression data for Philadelphia-Negative Chronic Myeloid Leukemia.

Pathways for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

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30KEGG, 4Cell Signaling Technology
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Pathways related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0BCR, ABL1
29.0BCR, ABL1
39.0BCR, ABL1

Compounds for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

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45Novoseek, 50PharmGKB, 11DrugBank
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Compounds related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1dasatinib45 50 1111.2BCR, ABL1
2cytarabine45 50 1111.2ABL1, BCR
3ceramide459.1BCR, ABL1
4agar459.1ABL1, ETV6
5dmso459.1ABL1, BCR
6phosphotyrosine459.0BCR, ABL1
7phenylalanine458.9BCR, ABL1
8imatinib45 50 1110.7BCR, ABL1, ETV6
9tyrosine458.2ETV6, ABL1, BCR

GO Terms for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

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16Gene Ontology
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Biological processes related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1actin cytoskeleton organizationGO:0300369.0BCR, ABL1
2platelet-derived growth factor receptor signaling pathwayGO:0480088.9BCR, ABL1
3regulation of cell cycleGO:0517268.7BCR, ABL1

Molecular functions related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein tyrosine kinase activityGO:0047139.0BCR, ABL1

Products for genes affiliated with Philadelphia-Negative Chronic Myeloid Leukemia

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Sources for Philadelphia-Negative Chronic Myeloid Leukemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet