MCID: PHL007
MIFTS: 21

Philadelphia-Negative Chronic Myeloid Leukemia

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Philadelphia-Negative Chronic Myeloid Leukemia

MalaCards integrated aliases for Philadelphia-Negative Chronic Myeloid Leukemia:

Name: Philadelphia-Negative Chronic Myeloid Leukemia 49

Classifications:



Summaries for Philadelphia-Negative Chronic Myeloid Leukemia

MalaCards based summary : Philadelphia-Negative Chronic Myeloid Leukemia is related to leukemia, chronic myeloid and myeloid leukemia. An important gene associated with Philadelphia-Negative Chronic Myeloid Leukemia is ABL1 (ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase), and among its related pathways/superpathways are Pathways in cancer and Chronic myeloid leukemia. Affiliated tissues include myeloid, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Philadelphia-Negative Chronic Myeloid Leukemia

Diseases related to Philadelphia-Negative Chronic Myeloid Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 leukemia, chronic myeloid 30.2 ABL1 BCR
2 myeloid leukemia 30.0 ABL1 BCR
3 leukemia 29.7 ABL1 BCR
4 pdgfrb-associated chronic eosinophilic leukemia 11.6
5 myeloproliferative neoplasm 9.8 ABL1 BCR
6 leukemia, acute lymphoblastic 3 9.8 ABL1 BCR
7 leukemia, acute lymphoblastic 9.8 ABL1 BCR
8 precursor t-cell acute lymphoblastic leukemia 9.7 ABL1 BCR
9 bone marrow cancer 9.7 ABL1 BCR
10 hematologic cancer 9.7 ABL1 BCR
11 essential thrombocythemia 9.7 ABL1 BCR
12 lymphoblastic leukemia 9.6 ABL1 BCR
13 leukemia, acute myeloid 9.5 ABL1 BCR

Graphical network of the top 20 diseases related to Philadelphia-Negative Chronic Myeloid Leukemia:



Diseases related to Philadelphia-Negative Chronic Myeloid Leukemia

Symptoms & Phenotypes for Philadelphia-Negative Chronic Myeloid Leukemia

GenomeRNAi Phenotypes related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards Suite gene sharing:

25 (show all 30)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.14 ABL1 BCR
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.14 ABL1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.14 BCR
4 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.14 BCR
5 Increased shRNA abundance (Z-score > 2) GR00366-A-123 10.14 ABL1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.14 BCR
7 Increased shRNA abundance (Z-score > 2) GR00366-A-151 10.14 ABL1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-157 10.14 ABL1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10.14 BCR
10 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.14 BCR
11 Increased shRNA abundance (Z-score > 2) GR00366-A-2 10.14 BCR
12 Increased shRNA abundance (Z-score > 2) GR00366-A-215 10.14 BCR
13 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.14 BCR
14 Increased shRNA abundance (Z-score > 2) GR00366-A-3 10.14 ABL1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.14 ABL1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.14 ABL1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.14 ABL1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-83 10.14 ABL1 BCR
19 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.14 BCR ABL1
20 Decreased viability GR00055-A-2 9.85 BCR
21 Decreased viability GR00221-A-1 9.85 ABL1
22 Decreased viability GR00221-A-2 9.85 ABL1 BCR
23 Decreased viability GR00221-A-3 9.85 ABL1
24 Decreased viability GR00221-A-4 9.85 BCR
25 Decreased viability GR00301-A 9.85 BCR
26 Decreased viability GR00342-S-1 9.85 ABL1
27 Decreased viability GR00342-S-2 9.85 ABL1
28 Decreased viability GR00342-S-3 9.85 ABL1
29 Decreased cell migration GR00055-A-1 9.26 ABL1 BCR
30 Increased circadian period length GR00213-A 8.96 BCR ABL1

Drugs & Therapeutics for Philadelphia-Negative Chronic Myeloid Leukemia

Search Clinical Trials , NIH Clinical Center for Philadelphia-Negative Chronic Myeloid Leukemia

Genetic Tests for Philadelphia-Negative Chronic Myeloid Leukemia

Anatomical Context for Philadelphia-Negative Chronic Myeloid Leukemia

MalaCards organs/tissues related to Philadelphia-Negative Chronic Myeloid Leukemia:

38
Myeloid

Publications for Philadelphia-Negative Chronic Myeloid Leukemia

Articles related to Philadelphia-Negative Chronic Myeloid Leukemia:

# Title Authors Year
1
Insertion (12;9)(p13;q34q34): a cryptic rearrangement involving ABL1/ETV6 fusion in a patient with Philadelphia-negative chronic myeloid leukemia. ( 19480935 )
2009
2
3' BCR recombines with IGL locus in BCR-ABL-positive philadelphia-negative chronic myeloid leukemia. ( 10534772 )
1999
3
Insertion of the 5' part of BCR within the ABL gene at 9q34 in a Philadelphia-negative chronic myeloid leukemia. ( 10526530 )
1999
4
A Philadelphia-negative chronic myeloid leukemia with a BCR/ABL fusion gene on chromosome 9. ( 9809034 )
1998
5
Translocation of BCR to chromosome 9 in a Philadelphia-negative chronic myeloid leukemia. ( 8536245 )
1995
6
Chromosome 22 breakpoints in variant Philadelphia translocations and Philadelphia-negative chronic myeloid leukemia. ( 2649233 )
1989
7
Translocation t(9;9)(p13;q34) in Philadelphia-negative chronic myeloid leukemia with breakpoint cluster region rearrangement. ( 2790772 )
1989

Variations for Philadelphia-Negative Chronic Myeloid Leukemia

Expression for Philadelphia-Negative Chronic Myeloid Leukemia

Search GEO for disease gene expression data for Philadelphia-Negative Chronic Myeloid Leukemia.

Pathways for Philadelphia-Negative Chronic Myeloid Leukemia

Pathways related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.98 ABL1 BCR
2
Show member pathways
11.34 ABL1 BCR
3 11.12 ABL1 BCR
4
Show member pathways
10.42 ABL1 BCR

GO Terms for Philadelphia-Negative Chronic Myeloid Leukemia

Cellular components related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein complex GO:0043234 8.62 ABL1 BCR

Biological processes related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.46 ABL1 BCR
2 protein phosphorylation GO:0006468 9.43 ABL1 BCR
3 protein autophosphorylation GO:0046777 9.4 ABL1 BCR
4 peptidyl-tyrosine phosphorylation GO:0018108 9.37 ABL1 BCR
5 actin cytoskeleton organization GO:0030036 9.32 ABL1 BCR
6 regulation of cell cycle GO:0051726 9.26 ABL1 BCR
7 cellular response to lipopolysaccharide GO:0071222 9.16 ABL1 BCR
8 neuromuscular process controlling balance GO:0050885 8.96 ABL1 BCR
9 platelet-derived growth factor receptor signaling pathway GO:0048008 8.62 ABL1 BCR

Molecular functions related to Philadelphia-Negative Chronic Myeloid Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 8.96 ABL1 BCR
2 protein tyrosine kinase activity GO:0004713 8.62 ABL1 BCR

Sources for Philadelphia-Negative Chronic Myeloid Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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