Aliases & Classifications for Phimosis

MalaCards integrated aliases for Phimosis:

Name: Phimosis 12 28 41 14 59
Tight Foreskin 12
Tight Frenulum 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2712
ICD10 32 N47.1
MeSH 41 D010688
NCIt 46 C26852
UMLS 69 C0031538

Summaries for Phimosis

PubMed Health : 59
About phimosis: Many parents feel concerned if their newborn or young boy’s foreskin cannot be pulled back. They may think his foreskin is too tight and that he might need an operation. But it is a little known fact that about 9 out of 10 boys’ foreskins are tight or stuck to the head of their penis when they are born. This is known as phimosis, and it is completely normal. It protects the sensitive head of the penis from rubbing against things, becoming too dry and coming into contact with germs like viruses or bacteria.Within the first three years of life, the stuck skin (adhesion) usually detaches, and tight foreskin usually loosens enough to be able to pull it back without any problems or pain. Treatment is only needed if the foreskin still can’t be pulled back in older boys or adult men.

MalaCards based summary : Phimosis, also known as tight foreskin, is related to lichen sclerosus and lichen sclerosus et atrophicus. An important gene associated with Phimosis is ELN (Elastin), and among its related pathways/superpathways are Degradation of the extracellular matrix and G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins. The drugs Anti-Allergic Agents and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, smooth muscle and bone.

Wikipedia : 72 Phimosis is a condition in which the foreskin of the penis cannot be pulled back past the glans. A... more...

Related Diseases for Phimosis

Diseases related to Phimosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 lichen sclerosus 10.2
2 lichen sclerosus et atrophicus 10.0
3 balanitis 10.0
4 epispadias 10.0
5 diabetes mellitus 9.9
6 hypospadias 9.9
7 leprosy 3 9.8
8 retinitis pigmentosa 9.8
9 leber congenital amaurosis 4 9.8
10 graft-versus-host disease 9.8
11 balanoposthitis 9.8
12 balanitis xerotica obliterans 9.8
13 retinitis 9.8
14 leukoplakia of penis 9.8
15 prune belly syndrome 9.7
16 epicanthus 9.7
17 mycosis fungoides 9.7
18 aging 9.7
19 blood group, junior system 9.7
20 glucocorticoid resistance, generalized 9.7
21 hydrops, lactic acidosis, and sideroblastic anemia 9.7
22 cataract 9.7
23 ptosis 9.7
24 cicatricial pemphigoid 9.7
25 urethritis 9.7
26 lymphangioma 9.7
27 cervicitis 9.7
28 dermatitis 9.7
29 cerebritis 9.7
30 primary syphilis 9.7
31 syphilis 9.7
32 paraphimosis 9.7
33 lichen planus 9.7
34 myotonic dystrophy 9.7
35 chronic graft versus host disease 9.7
36 hansen's disease 9.7
37 phacogenic glaucoma 9.6 ELN PEX19

Graphical network of the top 20 diseases related to Phimosis:



Diseases related to Phimosis

Symptoms & Phenotypes for Phimosis

Drugs & Therapeutics for Phimosis

PubMedHealth treatment related to Phimosis: 59

There is no need to treat phimosis in babies and toddlers right away. Parents should not try to force the foreskin back. This can be painful for the child and injure the foreskin, leading to scars that could later cause acquired phimosis. To keep the area clean, it is enough to wash the penis from the outside using warm water and mild soap.If a boy still has phimosis after the age of three, it is important to seek medical advice. The doctor will take a closer look and say whether treatment is advisable or whether you can wait and see how things develop.In most children, phimosis is treated using a steroid cream. This is known as a “conservative” treatment approach because surgery is not needed. The cream is applied to the foreskin twice a day for four to eight weeks. After two weeks parents can try to pull the foreskin back very gently in order to stretch it a little. Here it is important not to injure the skin. If the foreskin can be pulled back a bit, the cream can also be applied to the part of the glans that is exposed. Then the foreskin is returned to its normal position. This treatment is successful in most children. But it often has to be repeated after a while in order to have a more lasting effect.If conservative treatment doesn’t work, a small operation known as circumcision might be considered. This operation is also considered if boys have recurring inflammations or problems when urinating. Circumcision is always necessary if someone has phimosis due to scarring (acquired phimosis) or if the foreskin gets stuck behind the glans when it is pulled back (paraphimosis).Circumcision involves removing either part of the foreskin or all of it. If it is only partially removed, phimosis might come back again after a while. This cannot happen if all of the foreskin is removed.Circumcisions for the treatment of phimosis are routine operations. They are often done under general anesthetic in children, but sometimes only a local anesthetic is used in teenagers and adults.

Drugs for Phimosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Allergic Agents Phase 4
2 Anti-Inflammatory Agents Phase 4,Phase 1
3 Dermatologic Agents Phase 4
4 mometasone furoate Phase 4
5 glucocorticoids Phase 4
6 Hormone Antagonists Phase 4
7 Hormones Phase 4
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
9
Acetaminophen Approved Phase 1 103-90-2 1983
10
Bupivacaine Approved, Investigational Phase 1 38396-39-3, 2180-92-9 2474
11
Ibuprofen Approved Phase 1 15687-27-1 3672
12
Ketorolac Approved Phase 1 74103-06-3, 66635-83-4 3826
13
Sevoflurane Approved, Vet_approved Phase 1 28523-86-6 5206
14 Anesthetics Phase 1
15 Analgesics Phase 1
16 Analgesics, Non-Narcotic Phase 1
17 Anesthetics, General Phase 1
18 Anesthetics, Inhalation Phase 1
19 Anesthetics, Local Phase 1
20 Anti-Inflammatory Agents, Non-Steroidal Phase 1
21 Antipyretics Phase 1
22 Antirheumatic Agents Phase 1
23 Central Nervous System Depressants Phase 1
24 Cyclooxygenase Inhibitors Phase 1
25 Ketorolac Tromethamine Phase 1
26 Peripheral Nervous System Agents Phase 1
27 Platelet Aggregation Inhibitors Phase 1
28
Menthol Approved 2216-51-5 16666
29
Triamcinolone Approved, Vet_approved 124-94-7 31307
30
Formaldehyde Approved, Vet_approved 50-00-0 712
31
Adenosine Approved, Investigational 58-61-7 60961
32
Vitamin A Approved, Nutraceutical, Vet_approved 68-26-8, 11103-57-4 445354
33 Immunosuppressive Agents
34 Retinol palmitate
35 triamcinolone acetonide
36 Triamcinolone diacetate
37 Triamcinolone hexacetonide
38 retinol Nutraceutical

Interventional clinical trials:

(show all 12)

# Name Status NCT ID Phase Drugs
1 Treatment of Phimosis With Topical Steroid Cream -Double-blind, Randomized, Placebo-controlled Study Unknown status NCT01108198 Phase 4 Mometasone furoate cream;moisturizing cream
2 Mild Versus Potent Corticosteroids as Treatment for Phimosis in Children Withdrawn NCT00933023 Phase 4 hydrocortisone;Betamethasone
3 Evaluating Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision Recruiting NCT02973958 Phase 1 Bupivacaine;Sevoflurane;Acetaminophen;Ibuprofen;Ketorolac
4 Safety and Efficacy Study of Non-Surgical MC Device for Adolescent Male Population Including Contraindicated Subjects Unknown status NCT02581722
5 Follow Up Study to Evaluate a Non-Surgical Device for Adult Male Circumcision for Screen Failure Subjects Completed NCT02281435
6 Prospective, International Monosyn® Quick - Non Interventional Study Recruiting NCT03355001
7 Circumcision Versus Preputioplasty for BXO in Children Recruiting NCT02854995
8 Distribution of Smooth Muscle In Dartos In The Non Conspicuous Penis Recruiting NCT03295175
9 Susceptibility Genes in Autism Spectrum Disorders Recruiting NCT02628808
10 The Role of 2-octyl Cyanoacrylate in Prevention of Recurrent Adhesions After Circumcision Active, not recruiting NCT01794221
11 Natural History of IOL in Pseudo Exfoliation Syndrome Active, not recruiting NCT01255995
12 Intelligence Changes Following Minor Surgery Withdrawn NCT01483313

Search NIH Clinical Center for Phimosis

Cochrane evidence based reviews: phimosis

Genetic Tests for Phimosis

Genetic tests related to Phimosis:

# Genetic test Affiliating Genes
1 Phimosis 28

Anatomical Context for Phimosis

MalaCards organs/tissues related to Phimosis:

38
Skin, Smooth Muscle, Bone, Pituitary, Eye, Kidney, Bone Marrow

Publications for Phimosis

Articles related to Phimosis:

(show top 50) (show all 228)
# Title Authors Year
1
Expression of Xenobiotic Biomarkers CYP1 Family in Preputial Tissue of Patients with Hypospadias and Phimosis and Its Association with DNA Methylation Level of SRD5A2 Minimal Promoter. ( 29080015 )
2018
2
Observation time and spontaneous resolution of primary phimosis in children. ( 29019581 )
2017
3
Phimosis in a 10-yr-old Boy Without Urinary Infection-How to Inform Parents: Against Circumcision. ( 28753818 )
2017
4
Phimosis in a 10-yr-old Boy Without Urinary Infection-How to Inform Parents: For Circumcision. ( 28753815 )
2017
5
Para Phimosis Leading to Glans Gangrene - A Devastating Preventable Complication. ( 28418348 )
2017
6
Glans penis phimosis in antiquity as depicted upon two roman ex-votos. ( 29205160 )
2017
7
"Trident" preputial plasty for phimosis in childhood. ( 28359779 )
2017
8
Comparative efficacy and safety of different circumcisions for patients with redundant prepuce or phimosis: A network meta-analysis. ( 28522221 )
2017
9
Fournier's gangrene of the penis in a 12-year-old patient secondary to phimosis. ( 27903000 )
2016
10
Common urological problems in children: prepuce, phimosis, and buried penis. ( 27149978 )
2016
11
Phimosis in male dromedary camels: Clinical findings and changes in the hemogram, nitric oxide metabolites, and testosterone concentrations. ( 26879996 )
2016
12
High Risk Human Papillomavirus Infection of the Foreskin in Asymptomatic Men and Patients with Phimosis. ( 26796413 )
2016
13
Is steroids therapy effective in treating phimosis? A meta-analysis. ( 26725071 )
2016
14
Pathological Investigation of Childhood Foreskin: Are Lichen Sclerosus and Phimosis Common? ( 26876402 )
2016
15
2D:4D indicates phimosis risk: A study on digit ratio and early foreskin development. ( 27390108 )
2016
16
Postoperative occlusion of visual axis with fibrous membrane in the presence of anterior capsular phimosis in a patient with pseudoexfoliation syndrome: a case report. ( 27923362 )
2016
17
Commentary on "Phimosis with Preputial Fissures as a Predictor of Undiagnosed Type 2 Diabetes in Adults". ( 27275650 )
2016
18
Preputial bacterial colonisation in uncircumcised male children: Is it related to phimosis? ( 26968283 )
2016
19
Ultrastructural Analysis of the Foreskin in Patients With True Phimosis Treated or Not Treated With Topical Betamethasone and Hyaluronidase Ointment. ( 27443468 )
2016
20
Shut Phimosis in the Priapus Fresco From Pompeii. ( 25987495 )
2015
21
Indurative Edema of the Prepuce Mimicing Phimosis, an Atypical Manifestation of Primary Syphilis. ( 26724885 )
2015
22
Patient Satisfaction of Surgical Treatment of Clitoral Phimosis and Labial Adhesions Caused by Lichen Sclerosus. ( 26797058 )
2015
23
Acquired lymphangioma of the penis in a patient with severe phimosis. ( 26227086 )
2015
24
Phimosis with Preputial Fissures as a Predictor of Undiagnosed Type 2 Diabetes in Adults. ( 26349852 )
2015
25
The universal condition: medical constructions of 'congenital phimosis' in twentieth century New Zealand and their implications for child rearing. ( 25095486 )
2014
26
Capsulorhexis phimosis with anterior flexing ofA an accommodating IOL: Case report andA histopathological analyses. ( 24355727 )
2014
27
Topical corticosteroids for treating phimosis in boys. ( 25180668 )
2014
28
Is half strength of 0.05A % betamethasone valerate cream still effective in the treatment of phimosis in young children? ( 23292538 )
2013
29
Effect of topical steroid (0.05% clobetasol propionate) treatment in children with severe phimosis. ( 24044098 )
2013
30
Congenital phimosis in patients with and without lichen sclerosus: distinct expression patterns of tissue remodeling associated genes. ( 23174236 )
2013
31
Incidence of balanitis xerotica obliterans in boys younger than 10 years presenting with phimosis. ( 23296396 )
2013
32
Anterior capsular phimosis occluding the capsulorhexis opening after cataract surgery in a diabetic patient with high hemoglobin A1C. ( 23448558 )
2013
33
Acute presentation of clitoral phimosis in a 16-year-old girl. ( 24127974 )
2013
34
Prepuce-sparing plasty and simple running suture for phimosis. ( 23463932 )
2013
35
Re: Predictive power of objectivation of phimosis grade on outcomes of topical 0.1% betamethasone treatment of phimosis. ( 24029358 )
2013
36
Role of human papillomaviruses in persistent and glucocorticoid-resistant juvenile phimosis. ( 22471970 )
2013
37
Phimosis in childhood. ( 23788454 )
2013
38
Acquired phimosis after plastibell circumcision: a preventable consequence. ( 22943316 )
2012
39
Phimosis in children. ( 23002427 )
2012
40
Local steroid therapy as the first-line treatment for boys with symptomatic phimosis - a long-term prospective study. ( 22103624 )
2012
41
A novel approach to the surgical management of clitoral phimosis. ( 22555140 )
2012
42
Severe phimosis leading to obstructive uropathy in a boy with lichen sclerosus. ( 22594961 )
2012
43
An unusual case of foreskin phimosis after radiotherapy for rectal carcinoma. ( 22721756 )
2012
44
Enlargement lateral posthetectomy for phimosis in the infant: a new approach. ( 22503478 )
2012
45
Structural analysis of the phimotic prepuce in patients with failed topical treatment compared with untreated phimosis. ( 23302400 )
2012
46
Predictive power of objectivation of phimosis grade on outcomes of topical 0.1% betamethasone treatment of phimosis. ( 22749426 )
2012
47
Anterior capsular phimosis syndrome. ( 23229701 )
2012
48
Concealed male epispadias: a rare form of penile epispadias presenting as phimosis. ( 22090056 )
2011
49
Topical betamethasone and hyaluronidase in the treatment of phimosis in boys: a double-blind, randomized, placebo-controlled trial. ( 21756378 )
2011
50
Absolute measurement of androgen receptor mRNA in peripheral blood mononuclear, preputial skin and urethral mucosa cells of control individuals with phimosis using qRT-PCR. ( 22218452 )
2011

Variations for Phimosis

Expression for Phimosis

Search GEO for disease gene expression data for Phimosis.

Pathways for Phimosis

GO Terms for Phimosis

Cellular components related to Phimosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin complex GO:0008305 8.62 ITGA1 ITGB3

Biological processes related to Phimosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-matrix adhesion GO:0007160 9.16 ITGA1 ITGB3
2 integrin-mediated signaling pathway GO:0007229 8.96 ITGA1 ITGB3
3 extracellular matrix organization GO:0030198 8.8 ELN ITGA1 ITGB3

Molecular functions related to Phimosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix binding GO:0050840 8.62 ELN ITGB3

Sources for Phimosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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