Aliases & Classifications for Phimosis

MalaCards integrated aliases for Phimosis:

Name: Phimosis 12 29 42 14
Tight Foreskin 12
Tight Frenulum 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2712
ICD10 33 N47.1
MeSH 42 D010688
NCIt 47 C26852
UMLS 69 C0031538

Summaries for Phimosis

MalaCards based summary : Phimosis, also known as tight foreskin, is related to lichen sclerosus and balanitis. An important gene associated with Phimosis is ELN (Elastin), and among its related pathways/superpathways are Degradation of the extracellular matrix and L1CAM interactions. The drugs Anti-Allergic Agents and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, bone and skin.

Wikipedia : 72 Phimosis is a condition in which the foreskin of the penis cannot be pulled back past the glans. A... more...

Related Diseases for Phimosis

Diseases related to Phimosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)
id Related Disease Score Top Affiliating Genes
1 lichen sclerosus 10.1
2 balanitis 9.9
3 epispadias 9.9
4 olecranon bursitis 9.9 ELN PEX19
5 leprosy 9.8
6 retinitis 9.8
7 retinitis pigmentosa 9.8
8 hypospadias 9.8
9 balanoposthitis 9.8
10 balanitis xerotica obliterans 9.8
11 lymphangioma 9.6
12 cervicitis 9.6
13 dermatitis 9.6
14 prune belly syndrome 9.6
15 cerebritis 9.6
16 glucocorticoid resistance 9.6
17 primary syphilis 9.6
18 mycosis fungoides 9.6
19 syphilis 9.6
20 cataract 9.6
21 paraphimosis 9.6
22 lichen planus 9.6
23 ptosis 9.6
24 myotonic dystrophy 9.6
25 chronic graft versus host disease 9.6
26 cicatricial pemphigoid 9.6
27 hansen's disease 9.6
28 urethritis 9.6
29 urticaria 9.4 PEX19 WASHC4
30 acrodermatitis 7.0 ELN HOXA13 ITGA1 ITGB3 PEX19 PHIP

Graphical network of the top 20 diseases related to Phimosis:



Diseases related to Phimosis

Symptoms & Phenotypes for Phimosis

Drugs & Therapeutics for Phimosis

Drugs for Phimosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Allergic Agents Phase 4
2 Anti-Inflammatory Agents Phase 4,Phase 1
3 Dermatologic Agents Phase 4
4 mometasone furoate Phase 4 83919-23-7
5 glucocorticoids Phase 4
6 Hormone Antagonists Phase 4
7 Hormones Phase 4
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
9
Acetaminophen Approved Phase 1 103-90-2 1983
10
Bupivacaine Approved, Investigational Phase 1 2180-92-9, 38396-39-3 2474
11
Ibuprofen Approved Phase 1 15687-27-1 3672
12
Ketorolac Approved Phase 1 74103-06-3, 66635-83-4 3826
13
Sevoflurane Approved, Vet_approved Phase 1 28523-86-6 5206
14 Anesthetics Phase 1
15 Analgesics Phase 1
16 Analgesics, Non-Narcotic Phase 1
17 Anesthetics, General Phase 1
18 Anesthetics, Inhalation Phase 1
19 Anesthetics, Local Phase 1
20 Anti-Inflammatory Agents, Non-Steroidal Phase 1
21 Antipyretics Phase 1
22 Antirheumatic Agents Phase 1
23 Central Nervous System Depressants Phase 1
24 Cyclooxygenase Inhibitors Phase 1
25 Ketorolac Tromethamine Phase 1
26 Peripheral Nervous System Agents Phase 1
27 Platelet Aggregation Inhibitors Phase 1
28
Menthol Approved 2216-51-5 16666
29
Triamcinolone Approved, Vet_approved 124-94-7 31307
30
Adenosine Approved, Investigational 58-61-7 60961
31
Vitamin A Approved, Nutraceutical, Vet_approved 11103-57-4, 68-26-8 445354
32 Immunosuppressive Agents
33 Retinol palmitate
34 triamcinolone acetonide
35 Triamcinolone diacetate
36 Triamcinolone hexacetonide
37 retinol Nutraceutical

Interventional clinical trials:

(show all 11)

id Name Status NCT ID Phase Drugs
1 Treatment of Phimosis With Topical Steroid Cream -Double-blind, Randomized, Placebo-controlled Study Unknown status NCT01108198 Phase 4 Mometasone furoate cream;moisturizing cream
2 Mild Versus Potent Corticosteroids as Treatment for Phimosis in Children Withdrawn NCT00933023 Phase 4 hydrocortisone;Betamethasone
3 Evaluating Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision Recruiting NCT02973958 Phase 1 Bupivacaine;Sevoflurane;Acetaminophen;Ibuprofen;Ketorolac
4 Safety and Efficacy Study of Non-Surgical MC Device for Adolescent Male Population Including Contraindicated Subjects Unknown status NCT02581722
5 Follow Up Study to Evaluate a Non-Surgical Device for Adult Male Circumcision for Screen Failure Subjects Completed NCT02281435
6 Circumcision Versus Preputioplasty for BXO in Children Recruiting NCT02854995
7 Distribution of Smooth Muscle In Dartos In The Non Conspicuous Penis Recruiting NCT03295175
8 Susceptibility Genes in Autism Spectrum Disorders Recruiting NCT02628808
9 The Role of 2-octyl Cyanoacrylate in Prevention of Recurrent Adhesions After Circumcision Active, not recruiting NCT01794221
10 Natural History of IOL in Pseudo Exfoliation Syndrome Active, not recruiting NCT01255995
11 Intelligence Changes Following Minor Surgery Withdrawn NCT01483313

Search NIH Clinical Center for Phimosis

Cochrane evidence based reviews: phimosis

Genetic Tests for Phimosis

Genetic tests related to Phimosis:

id Genetic test Affiliating Genes
1 Phimosis 29

Anatomical Context for Phimosis

MalaCards organs/tissues related to Phimosis:

39
Smooth Muscle, Bone, Skin, Pituitary, Kidney, Bone Marrow, Eye

Publications for Phimosis

Articles related to Phimosis:

(show top 50) (show all 225)
id Title Authors Year
1
Phimosis in a 10-yr-old Boy Without Urinary Infection-How to Inform Parents: Against Circumcision. ( 28753818 )
2017
2
Comparative efficacy and safety of different circumcisions for patients with redundant prepuce or phimosis: A network meta-analysis. ( 28522221 )
2017
3
Phimosis in a 10-yr-old Boy Without Urinary Infection-How to Inform Parents: For Circumcision. ( 28753815 )
2017
4
"Trident" preputial plasty for phimosis in childhood. ( 28359779 )
2017
5
Para Phimosis Leading to Glans Gangrene - A Devastating Preventable Complication. ( 28418348 )
2017
6
Postoperative occlusion of visual axis with fibrous membrane in the presence of anterior capsular phimosis in a patient with pseudoexfoliation syndrome: a case report. ( 27923362 )
2016
7
Fournier's gangrene of the penis in a 12-year-old patient secondary to phimosis. ( 27903000 )
2016
8
Pathological Investigation of Childhood Foreskin: Are Lichen Sclerosus and Phimosis Common? ( 26876402 )
2016
9
Common urological problems in children: prepuce, phimosis, and buried penis. ( 27149978 )
2016
10
Ultrastructural Analysis of the Foreskin in Patients With True Phimosis Treated or Not Treated With Topical Betamethasone and Hyaluronidase Ointment. ( 27443468 )
2016
11
High Risk Human Papillomavirus Infection of the Foreskin in Asymptomatic Men and Patients with Phimosis. ( 26796413 )
2016
12
2D:4D indicates phimosis risk: A study on digit ratio and early foreskin development. ( 27390108 )
2016
13
Is steroids therapy effective in treating phimosis? A meta-analysis. ( 26725071 )
2016
14
Commentary on "Phimosis with Preputial Fissures as a Predictor of Undiagnosed Type 2 Diabetes in Adults". ( 27275650 )
2016
15
Phimosis in male dromedary camels: Clinical findings and changes in the hemogram, nitric oxide metabolites, and testosterone concentrations. ( 26879996 )
2016
16
Preputial bacterial colonisation in uncircumcised male children: Is it related to phimosis? ( 26968283 )
2016
17
Phimosis with Preputial Fissures as a Predictor of Undiagnosed Type 2 Diabetes in Adults. ( 26349852 )
2015
18
Shut Phimosis in the Priapus Fresco From Pompeii. ( 25987495 )
2015
19
Patient Satisfaction of Surgical Treatment of Clitoral Phimosis and Labial Adhesions Caused by Lichen Sclerosus. ( 26797058 )
2015
20
Acquired lymphangioma of the penis in a patient with severe phimosis. ( 26227086 )
2015
21
Indurative Edema of the Prepuce Mimicing Phimosis, an Atypical Manifestation of Primary Syphilis. ( 26724885 )
2015
22
The universal condition: medical constructions of 'congenital phimosis' in twentieth century New Zealand and their implications for child rearing. ( 25095486 )
2014
23
Capsulorhexis phimosis with anterior flexing ofA an accommodating IOL: Case report andA histopathological analyses. ( 24355727 )
2014
24
Topical corticosteroids for treating phimosis in boys. ( 25180668 )
2014
25
Role of human papillomaviruses in persistent and glucocorticoid-resistant juvenile phimosis. ( 22471970 )
2013
26
Phimosis in childhood. ( 23788454 )
2013
27
Incidence of balanitis xerotica obliterans in boys younger than 10 years presenting with phimosis. ( 23296396 )
2013
28
Prepuce-sparing plasty and simple running suture for phimosis. ( 23463932 )
2013
29
Acute presentation of clitoral phimosis in a 16-year-old girl. ( 24127974 )
2013
30
Is half strength of 0.05A % betamethasone valerate cream still effective in the treatment of phimosis in young children? ( 23292538 )
2013
31
Anterior capsular phimosis occluding the capsulorhexis opening after cataract surgery in a diabetic patient with high hemoglobin A1C. ( 23448558 )
2013
32
Re: Predictive power of objectivation of phimosis grade on outcomes of topical 0.1% betamethasone treatment of phimosis. ( 24029358 )
2013
33
Congenital phimosis in patients with and without lichen sclerosus: distinct expression patterns of tissue remodeling associated genes. ( 23174236 )
2013
34
Effect of topical steroid (0.05% clobetasol propionate) treatment in children with severe phimosis. ( 24044098 )
2013
35
Acquired phimosis after plastibell circumcision: a preventable consequence. ( 22943316 )
2012
36
Severe phimosis leading to obstructive uropathy in a boy with lichen sclerosus. ( 22594961 )
2012
37
Phimosis in children. ( 23002427 )
2012
38
Enlargement lateral posthetectomy for phimosis in the infant: a new approach. ( 22503478 )
2012
39
Predictive power of objectivation of phimosis grade on outcomes of topical 0.1% betamethasone treatment of phimosis. ( 22749426 )
2012
40
A novel approach to the surgical management of clitoral phimosis. ( 22555140 )
2012
41
An unusual case of foreskin phimosis after radiotherapy for rectal carcinoma. ( 22721756 )
2012
42
Anterior capsular phimosis syndrome. ( 23229701 )
2012
43
Structural analysis of the phimotic prepuce in patients with failed topical treatment compared with untreated phimosis. ( 23302400 )
2012
44
Local steroid therapy as the first-line treatment for boys with symptomatic phimosis - a long-term prospective study. ( 22103624 )
2012
45
Topical betamethasone and hyaluronidase in the treatment of phimosis in boys: a double-blind, randomized, placebo-controlled trial. ( 21756378 )
2011
46
Prepuce: phimosis, paraphimosis, and circumcision. ( 21298220 )
2011
47
Atypical phimosis secondary to a preputial metastasis from rectal carcinoma. ( 22187540 )
2011
48
Concealed male epispadias: a rare form of penile epispadias presenting as phimosis. ( 22090056 )
2011
49
Absolute measurement of androgen receptor mRNA in peripheral blood mononuclear, preputial skin and urethral mucosa cells of control individuals with phimosis using qRT-PCR. ( 22218452 )
2011
50
Rapid capsular phimosis in retinitis pigmentosa. ( 20726501 )
2010

Variations for Phimosis

Expression for Phimosis

Search GEO for disease gene expression data for Phimosis.

Pathways for Phimosis

GO Terms for Phimosis

Cellular components related to Phimosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integrin complex GO:0008305 8.62 ITGA1 ITGB3

Biological processes related to Phimosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell-matrix adhesion GO:0007160 9.16 ITGA1 ITGB3
2 integrin-mediated signaling pathway GO:0007229 8.96 ITGA1 ITGB3
3 extracellular matrix organization GO:0030198 8.8 ELN ITGA1 ITGB3

Molecular functions related to Phimosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix binding GO:0050840 8.62 ELN ITGB3

Sources for Phimosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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