MCID: PHM001
MIFTS: 37

Phimosis malady

Categories: Reproductive diseases

Aliases & Classifications for Phimosis

Aliases & Descriptions for Phimosis:

Name: Phimosis 12 29 42 14
Tight Foreskin 12
Tight Frenulum 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2712
ICD10 33 N47.1
MeSH 42 D010688
NCIt 47 C26852
UMLS 69 C0031538

Summaries for Phimosis

MalaCards based summary : Phimosis, also known as tight foreskin, is related to lichen sclerosus and olecranon bursitis. An important gene associated with Phimosis is ITGA1 (Integrin Subunit Alpha 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and L1CAM interactions. The drugs Anti-Allergic Agents and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and pituitary.

Wikipedia : 71 Phimosis is a condition in which the foreskin of the penis cannot be pulled back past the glans. A... more...

Related Diseases for Phimosis

Diseases related to Phimosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
id Related Disease Score Top Affiliating Genes
1 lichen sclerosus 10.1
2 olecranon bursitis 10.0 ELN PEX19
3 balanitis 9.9
4 epispadias 9.9
5 retinitis pigmentosa 9.8
6 hypospadias 9.8
7 balanoposthitis 9.8
8 balanitis xerotica obliterans 9.8
9 leprosy 9.8
10 retinitis 9.8
11 glucocorticoid resistance 9.6
12 primary syphilis 9.6
13 mycosis fungoides 9.6
14 syphilis 9.6
15 cataract 9.6
16 paraphimosis 9.6
17 lichen planus 9.6
18 ptosis 9.6
19 myotonic dystrophy 9.6
20 chronic graft versus host disease 9.6
21 cicatricial pemphigoid 9.6
22 hansen's disease 9.6
23 urethritis 9.6
24 lymphangioma 9.6
25 cervicitis 9.6
26 dermatitis 9.6
27 prune belly syndrome 9.6
28 cerebritis 9.6
29 acrodermatitis 8.8 ELN HOXA13 ITGA1 ITGB3 PEX19 PHIP

Graphical network of the top 20 diseases related to Phimosis:



Diseases related to Phimosis

Symptoms & Phenotypes for Phimosis

Drugs & Therapeutics for Phimosis

Drugs for Phimosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Allergic Agents Phase 4
2 Anti-Inflammatory Agents Phase 4,Phase 1
3 Dermatologic Agents Phase 4
4 mometasone furoate Phase 4 83919-23-7
5 glucocorticoids Phase 4
6 Hormone Antagonists Phase 4
7 Hormones Phase 4
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
9
Acetaminophen Approved Phase 1 103-90-2 1983
10
Bupivacaine Approved, Investigational Phase 1 2180-92-9, 38396-39-3 2474
11
Ibuprofen Approved Phase 1 15687-27-1 3672
12
Ketorolac Approved Phase 1 74103-06-3, 66635-83-4 3826
13
Sevoflurane Approved, Vet_approved Phase 1 28523-86-6 5206
14 Anesthetics Phase 1
15 Analgesics Phase 1
16 Analgesics, Non-Narcotic Phase 1
17 Anesthetics, General Phase 1
18 Anesthetics, Inhalation Phase 1
19 Anesthetics, Local Phase 1
20 Anti-Inflammatory Agents, Non-Steroidal Phase 1
21 Antipyretics Phase 1
22 Antirheumatic Agents Phase 1
23 Central Nervous System Depressants Phase 1
24 Cyclooxygenase Inhibitors Phase 1
25 Ketorolac Tromethamine Phase 1
26 Peripheral Nervous System Agents Phase 1
27 Platelet Aggregation Inhibitors Phase 1
28
Menthol Approved 2216-51-5 16666
29
Triamcinolone Approved, Vet_approved 124-94-7 31307
30
Vitamin A Approved, Nutraceutical, Vet_approved 11103-57-4, 68-26-8 445354
31 Immunosuppressive Agents
32 Retinol palmitate
33 triamcinolone acetonide
34 Triamcinolone diacetate
35 Triamcinolone hexacetonide
36 retinol Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase
1 Treatment of Phimosis With Topical Steroid Cream -Double-blind, Randomized, Placebo-controlled Study Unknown status NCT01108198 Phase 4
2 Mild Versus Potent Corticosteroids as Treatment for Phimosis in Children Withdrawn NCT00933023 Phase 4
3 Evaluating Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision Not yet recruiting NCT02973958 Phase 1
4 Follow Up Study to Evaluate a Non-Surgical Device for Adult Male Circumcision for Screen Failure Subjects Completed NCT02281435
5 Circumcision Versus Preputioplasty for BXO in Children Recruiting NCT02854995
6 Susceptibility Genes in Autism Spectrum Disorders Recruiting NCT02628808
7 The Role of 2-octyl Cyanoacrylate in Prevention of Recurrent Adhesions After Circumcision Active, not recruiting NCT01794221
8 Safety and Efficacy Study of Non-Surgical MC Device for Adolescent Male Population Including Contraindicated Subjects Active, not recruiting NCT02581722
9 Natural History of IOL in Pseudo Exfoliation Syndrome Active, not recruiting NCT01255995
10 Intelligence Changes Following Minor Surgery Withdrawn NCT01483313

Search NIH Clinical Center for Phimosis

Cochrane evidence based reviews: phimosis

Genetic Tests for Phimosis

Genetic tests related to Phimosis:

id Genetic test Affiliating Genes
1 Phimosis 29

Anatomical Context for Phimosis

MalaCards organs/tissues related to Phimosis:

39
Bone, Skin, Pituitary, Eye, Kidney, Bone Marrow

Publications for Phimosis

Articles related to Phimosis:

(show top 50) (show all 220)
id Title Authors Year
1
Postoperative occlusion of visual axis with fibrous membrane in the presence of anterior capsular phimosis in a patient with pseudoexfoliation syndrome: a case report. ( 27923362 )
2016
2
High Risk Human Papillomavirus Infection of the Foreskin in Asymptomatic Men and Patients with Phimosis. ( 26796413 )
2016
3
Phimosis in male dromedary camels: Clinical findings and changes in the hemogram, nitric oxide metabolites, and testosterone concentrations. ( 26879996 )
2016
4
2D:4D indicates phimosis risk: A study on digit ratio and early foreskin development. ( 27390108 )
2016
5
Preputial bacterial colonisation in uncircumcised male children: Is it related to phimosis? ( 26968283 )
2016
6
Pathological Investigation of Childhood Foreskin: Are Lichen Sclerosus and Phimosis Common? ( 26876402 )
2016
7
Fournier's gangrene of the penis in a 12-year-old patient secondary to phimosis. ( 27903000 )
2016
8
Is steroids therapy effective in treating phimosis? A meta-analysis. ( 26725071 )
2016
9
Common urological problems in children: prepuce, phimosis, and buried penis. ( 27149978 )
2016
10
Ultrastructural Analysis of the Foreskin in Patients With True Phimosis Treated or Not Treated With Topical Betamethasone and Hyaluronidase Ointment. ( 27443468 )
2016
11
Commentary on "Phimosis with Preputial Fissures as a Predictor of Undiagnosed Type 2 Diabetes in Adults". ( 27275650 )
2016
12
Indurative Edema of the Prepuce Mimicing Phimosis, an Atypical Manifestation of Primary Syphilis. ( 26724885 )
2015
13
Phimosis with Preputial Fissures as a Predictor of Undiagnosed Type 2 Diabetes in Adults. ( 26349852 )
2015
14
Acquired lymphangioma of the penis in a patient with severe phimosis. ( 26227086 )
2015
15
Patient Satisfaction of Surgical Treatment of Clitoral Phimosis and Labial Adhesions Caused by Lichen Sclerosus. ( 26797058 )
2015
16
Shut Phimosis in the Priapus Fresco From Pompeii. ( 25987495 )
2015
17
Capsulorhexis phimosis with anterior flexing ofA an accommodating IOL: Case report andA histopathological analyses. ( 24355727 )
2014
18
The universal condition: medical constructions of 'congenital phimosis' in twentieth century New Zealand and their implications for child rearing. ( 25095486 )
2014
19
Topical corticosteroids for treating phimosis in boys. ( 25180668 )
2014
20
Phimosis in childhood. ( 23788454 )
2013
21
Re: Predictive power of objectivation of phimosis grade on outcomes of topical 0.1% betamethasone treatment of phimosis. ( 24029358 )
2013
22
Is half strength of 0.05A % betamethasone valerate cream still effective in the treatment of phimosis in young children? ( 23292538 )
2013
23
Effect of topical steroid (0.05% clobetasol propionate) treatment in children with severe phimosis. ( 24044098 )
2013
24
Incidence of balanitis xerotica obliterans in boys younger than 10 years presenting with phimosis. ( 23296396 )
2013
25
Role of human papillomaviruses in persistent and glucocorticoid-resistant juvenile phimosis. ( 22471970 )
2013
26
Prepuce-sparing plasty and simple running suture for phimosis. ( 23463932 )
2013
27
Acute presentation of clitoral phimosis in a 16-year-old girl. ( 24127974 )
2013
28
Anterior capsular phimosis occluding the capsulorhexis opening after cataract surgery in a diabetic patient with high hemoglobin A1C. ( 23448558 )
2013
29
Congenital phimosis in patients with and without lichen sclerosus: distinct expression patterns of tissue remodeling associated genes. ( 23174236 )
2013
30
Severe phimosis leading to obstructive uropathy in a boy with lichen sclerosus. ( 22594961 )
2012
31
A novel approach to the surgical management of clitoral phimosis. ( 22555140 )
2012
32
Phimosis in children. ( 23002427 )
2012
33
An unusual case of foreskin phimosis after radiotherapy for rectal carcinoma. ( 22721756 )
2012
34
Anterior capsular phimosis syndrome. ( 23229701 )
2012
35
Enlargement lateral posthetectomy for phimosis in the infant: a new approach. ( 22503478 )
2012
36
Acquired phimosis after plastibell circumcision: a preventable consequence. ( 22943316 )
2012
37
Structural analysis of the phimotic prepuce in patients with failed topical treatment compared with untreated phimosis. ( 23302400 )
2012
38
Predictive power of objectivation of phimosis grade on outcomes of topical 0.1% betamethasone treatment of phimosis. ( 22749426 )
2012
39
Local steroid therapy as the first-line treatment for boys with symptomatic phimosis - a long-term prospective study. ( 22103624 )
2012
40
Prepuce: phimosis, paraphimosis, and circumcision. ( 21298220 )
2011
41
Concealed male epispadias: a rare form of penile epispadias presenting as phimosis. ( 22090056 )
2011
42
Absolute measurement of androgen receptor mRNA in peripheral blood mononuclear, preputial skin and urethral mucosa cells of control individuals with phimosis using qRT-PCR. ( 22218452 )
2011
43
Atypical phimosis secondary to a preputial metastasis from rectal carcinoma. ( 22187540 )
2011
44
Topical betamethasone and hyaluronidase in the treatment of phimosis in boys: a double-blind, randomized, placebo-controlled trial. ( 21756378 )
2011
45
Topical mometasone furoate for phimosis. ( 20371899 )
2010
46
Re: Is suppression of hypothalamic-pituitary-adrenal axis significant during clinical treatment of phimosis? F. O. Pileggi, C. E. Martinelli, Jr., M. F. G. S. Tazima, J. C. Daneluzzi and Y. A. M. V. A. Vicente J Urol 2010; 183: 2327-2331. ( 20673924 )
2010
47
Clinicopathologic correlation of capsulorhexis phimosis with anterior flexing of single-piece hydrophilic acrylic intraocular lens haptics. ( 20692577 )
2010
48
Laser treatment alternative to IOL exchange for capsulorhexis phimosis with anterior flexing of single-piece hydrophilic acrylic IOL haptics. ( 21111343 )
2010
49
Rapid capsular phimosis in retinitis pigmentosa. ( 20726501 )
2010
50
Topical steroid is effective for the treatment of phimosis in young children. ( 20196415 )
2010

Variations for Phimosis

Expression for Phimosis

Search GEO for disease gene expression data for Phimosis.

Pathways for Phimosis

GO Terms for Phimosis

Cellular components related to Phimosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integrin complex GO:0008305 8.62 ITGA1 ITGB3

Biological processes related to Phimosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell-matrix adhesion GO:0007160 9.16 ITGA1 ITGB3
2 integrin-mediated signaling pathway GO:0007229 8.96 ITGA1 ITGB3
3 extracellular matrix organization GO:0030198 8.8 ELN ITGA1 ITGB3

Molecular functions related to Phimosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix binding GO:0050840 8.62 ELN ITGB3

Sources for Phimosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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