MCID: PHB003
MIFTS: 31

Phobia, Specific

Categories: Mental diseases

Aliases & Classifications for Phobia, Specific

MalaCards integrated aliases for Phobia, Specific:

Name: Phobia, Specific 54 13 42 69
Specific Phobia 12 14
Simple Phobia 12

Classifications:



External Ids:

OMIM 54 608251
Disease Ontology 12 DOID:599
ICD10 33 F40.2
MeSH 42 C562465
NCIt 47 C35284
SNOMED-CT 64 192396001 54587008
UMLS 69 C0236801

Summaries for Phobia, Specific

Disease Ontology : 12 A phobic disorder that is characterized by an unreasonable or irrational fear related to exposure to specific objects or situations.

MalaCards based summary : Phobia, Specific, also known as specific phobia, is related to chronic cervicitis and renpenning syndrome. An important gene associated with Phobia, Specific is PHOBS (Phobia, Specific), and among its related pathways/superpathways are Tyrosine metabolism and Neurotransmitter Clearance In The Synaptic Cleft. The drugs Citalopram and Antidepressive Agents have been mentioned in the context of this disorder. Affiliated tissues include brain.

Wikipedia : 72 A specific phobia is any kind of anxiety disorder that amounts to an unreasonable or irrational fear... more...

Description from OMIM: 608251

Related Diseases for Phobia, Specific

Diseases related to Phobia, Specific via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
id Related Disease Score Top Affiliating Genes
1 chronic cervicitis 10.2 FMR1 MAOA
2 renpenning syndrome 10.1 COMT MAOA
3 hemorrhagic cystitis 10.1 COMT MAOA
4 amyloidosis, finnish type 10.1 COMT MAOA
5 tongue disease 10.1 COMT MAOA
6 intrahepatic gall duct cancer 10.1 COMT MAOA
7 chronic dacryoadenitis 10.1 COMT MAOA
8 pauci-immune glomerulonephritis with anca 10.1 COMT MAOA
9 obsessive-compulsive personality disorder 10.1 COMT MAOA
10 keratosis 10.1 COMT MAOA
11 carotid stenosis 10.0 COMT MAOA
12 cecal benign neoplasm 10.0 COMT MAOA
13 chagas disease 10.0 COMT MAOA
14 colon mucinous adenocarcinoma 10.0 COMT MAOA
15 hereditary multiple exostoses 10.0 COMT MAOA
16 vallecula cancer 10.0 COMT MAOA
17 social phobia 9.9
18 parkinsonism-dystonia, infantile 9.9 COMT MAOA
19 pervasive developmental disorder 9.9 COMT FMR1
20 may-hegglin anomaly 9.8 COMT MAOA
21 hepatitis d 9.8 COMT MAOA
22 albinism, oculocutaneous, type v 9.8 COMT MAOA
23 panic disorder 9.8
24 anxiety disorder 9.8
25 aicardi-goutieres syndrome 2 9.7 COMT MAOA
26 velocardiofacial syndrome 9.7
27 uterus intravascular leiomyomatosis 9.6 COMT MAOA NBAS
28 personality disorder 9.6 COMT FMR1 MAOA
29 sexual disorder 9.6 COMT FMR1 MAOA
30 obsessive-compulsive disorder 9.6
31 bipolar disorder 9.6
32 separation anxiety disorder 9.6
33 hypochondriasis 9.6
34 generalized anxiety disorder 9.6
35 craniosynostosis, adelaide type 9.6 COMT FMR1 MAOA
36 partial motor epilepsy 9.5 COMT MAOA
37 ring chromosome 14 syndrome 7.5 COMT CTU2 FMR1 MAOA NBAS PHOBS

Graphical network of the top 20 diseases related to Phobia, Specific:



Diseases related to Phobia, Specific

Symptoms & Phenotypes for Phobia, Specific

Clinical features from OMIM:

608251

Drugs & Therapeutics for Phobia, Specific

Drugs for Phobia, Specific (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Citalopram Approved Phase 2, Phase 3 59729-33-8 2771
2 Antidepressive Agents Phase 2, Phase 3
3 Antidepressive Agents, Second-Generation Phase 2, Phase 3
4 Antiparkinson Agents Phase 2, Phase 3
5 Autonomic Agents Phase 2, Phase 3
6 Cholinergic Agents Phase 2, Phase 3
7 Cholinergic Antagonists Phase 2, Phase 3
8 Muscarinic Antagonists Phase 2, Phase 3
9 Neurotransmitter Agents Phase 2, Phase 3
10 Neurotransmitter Uptake Inhibitors Phase 2, Phase 3
11 Parasympatholytics Phase 2, Phase 3
12 Peripheral Nervous System Agents Phase 2, Phase 3
13 Psychotropic Drugs Phase 2, Phase 3
14
Serotonin Phase 2, Phase 3 50-67-9 5202
15 Serotonin Agents Phase 2, Phase 3
16 Serotonin Uptake Inhibitors Phase 2, Phase 3
17
Cycloserine Approved Phase 2,Phase 1 68-41-7 401 6234
18
Valproic Acid Approved, Investigational Phase 2 99-66-1 3121
19 Anti-Bacterial Agents Phase 2,Phase 1
20 Antibiotics, Antitubercular Phase 2,Phase 1
21 Anti-Infective Agents Phase 2,Phase 1
22 Antimetabolites Phase 2,Phase 1
23 Antitubercular Agents Phase 2,Phase 1
24 Renal Agents Phase 2,Phase 1
25 Anti-Anxiety Agents Phase 2
26 Antipsychotic Agents Phase 2
27 Central Nervous System Depressants Phase 2
28 Quetiapine Fumarate Phase 2 111974-72-2
29 Tranquilizing Agents Phase 2
30 Anticonvulsants Phase 2
31 Antimanic Agents Phase 2
32 GABA Agents Phase 2
33 Pharmaceutical Solutions Phase 2
34 Nootropic Agents Phase 1, Phase 2
35
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
36
Midazolam Approved, Illicit 59467-70-8 4192
37
Nitrous oxide Approved, Vet_approved 10024-97-2 948
38
Benzocaine Approved 1994-09-7, 94-09-7 2337
39 tannic acid Approved, Nutraceutical
40
Imidacloprid Vet_approved 105827-78-9 86418
41 Contraceptive Agents
42 Estradiol 17 beta-cypionate
43 Estradiol 3-benzoate
44 Estradiol valerate 979-32-8
45 Estrogens
46 Hormone Antagonists
47 Hormones
48 Hormones, Hormone Substitutes, and Hormone Antagonists
49 Polyestradiol phosphate
50 Complement System Proteins

Interventional clinical trials:

(show top 50) (show all 58)

id Name Status NCT ID Phase Drugs
1 Transfer of Manualized Cognitive-Behavioral Therapy (CBT) for Social Phobia Into Clinical Practice Unknown status NCT01388231 Phase 2, Phase 3
2 Study of Escitalopram in the Treatment of Specific Phobia Completed NCT00121069 Phase 2, Phase 3 Escitalopram
3 Virtual Reality Exposure Therapy in Agoraphobic Participants Completed NCT00734370 Phase 2, Phase 3
4 Psychotherapy for Anxiety in Children With Autism Spectrum Disorder Recruiting NCT02028247 Phase 3
5 Treatment Study for Rural Latino Youth With Anxiety Unknown status NCT01491880 Phase 1, Phase 2
6 Quetiapine in Specific Phobia Completed NCT00872716 Phase 2 Quetiapine XR
7 Treatment for Specific Phobias in Children Completed NCT00051220 Phase 1, Phase 2
8 fMRI Study Examining Effects of D-cycloserine in Specific Phobia Completed NCT00591825 Phase 2 D-cycloserine;Placebo
9 D-cycloserine and Treatment of Feeding Disorders Completed NCT01923896 Phase 1, Phase 2 d-cycloserine (DCS);Placebo
10 Brief Behavioral Treatment for Anxiety in Young Children Completed NCT02051192 Phase 1, Phase 2
11 Influence of Valproic Acid on Extinction-based Therapy in Patients With Fear of Spiders. Recruiting NCT02789813 Phase 2 Valproic Acid;Placebo
12 Effects of Low-Level Laser Stimulation With and Without Fear Extinction Training Recruiting NCT02926352 Phase 1, Phase 2
13 Enhancing Exposure Therapy for Snake and Spider Phobias Active, not recruiting NCT02160470 Phase 1, Phase 2
14 The Modular Protocol for Mental Health (MPMH) Enrolling by invitation NCT03143634 Phase 1, Phase 2
15 Intervention for Anxiety After Falls Completed NCT01268657 Phase 1
16 Time Intensive CBT for a Specific Phobia of Vomiting Recruiting NCT02920814 Phase 1
17 D-Cycloserine-Enhancer of One-Session Treatment for Phobia of Heights Unknown status NCT01037101 D-Cycloserine;Placebo
18 Parent-Augmented Cognitive Behavioral Therapy to Treat Children With Specific Phobias Completed NCT00509951
19 The Impact of Sex Hormones on One-session Treatment for Spider Phobia in Women Completed NCT02622087
20 Study of Brain Circuitry in Anxiety Disorders Completed NCT01849432
21 Extinction Generalization in Exposure Therapy Completed NCT03031002
22 Validity of a Self-administered Questionnaire to Screen Phobia of Falling in the Elderly Completed NCT02387047
23 Exposure, D-cycloserine Enhancement, and Functional Magnetic Resonance Imaging (fMRI) in Snake Phobics Completed NCT01450306 D-cycloserine;Placebo
24 Internet-delivered Treatment for Children With Anxiety Disorders in a Rural Area; an Open Trial in a Clinical Setting Completed NCT02306356
25 In Vivo Versus Augmented Reality Exposure for Small Animal Phobia Completed NCT01361074
26 Internet-delivered Cognitive Behavior Therapy (CBT) for Children Age 8-12 Years With Anxiety Disorders Completed NCT01533402
27 Clinical Management of Anxiety and Access to Health Care Completed NCT02081365
28 Changes in Brain Activity (Functional MRI Study) Before and After Behavioral Therapy of Height Phobia Completed NCT00302978
29 EMDR in Spider Phobia: Work Mechanisms and Treatment Outcome Completed NCT02973919
30 Children and Adolescents With Dental Anxiety - Randomized Controlled Study of Cognitive Behavioral Therapy Completed NCT01798355
31 Online, Guided Interventions to Reduce Generalized Anxiety Disorder Among Indian University Students Completed NCT02410265
32 Use of Virtual Reality in the Treatment of Flying Phobia Completed NCT01442805
33 Cognitive Behavioral Therapy in Panic Disorder Completed NCT00772746
34 How to Act on the Mobility Restriction Linked to Senior's Phobia of Falling Recruiting NCT02554838
35 Self-efficacy Enhancement and Exposure Therapy Recruiting NCT03105024
36 Anti-phobic and Safety Behaviors in the Treatment of Acrophobia Recruiting NCT02085343
37 The Effects of Safety Seeking Behaviors During Exposure Therapy for Adults With Spider Phobia Recruiting NCT03233113
38 Spider Phobia Opposite Action Treatment Study Recruiting NCT02905279
39 tDCS-Augmented Exposure Therapy for Pathological Fear Recruiting NCT03095482
40 Providing Tools for Effective Care and Treatment of Anxiety Disorders Recruiting NCT02605668
41 Transdiagnostic REBT Prevention Program for Adolescents Recruiting NCT02756507
42 Building an Outcomes Assessment Infrastructure to Assess Anxiety Treatment Recruiting NCT02305537
43 Transdiagnostic Psychotherapy for Veterans With Mood and Anxiety Disorders Recruiting NCT01947647
44 Internet-delivered Transdiagnostic Intervention for Anxiety and Depression Recruiting NCT02739607
45 Dimensional Brain Behavior Predictors of CBT Outcomes in Pediatric Anxiety Recruiting NCT02810171
46 Effect of Mindfulness Meditation on Physiological Response to Unpredictable Stimuli Recruiting NCT03206437
47 Internet-Based Cognitive Behavioral Therapy for Children With Dental Anxiety Recruiting NCT02588079
48 Treating Emotional Disorders in Primary Care With Psychological Techniques Recruiting NCT01903096 Primary Care Treatment As Usual
49 Virtual Reality Immersive Method for Spider (Phobia) Exposure Therapy (VIMSE) Active, not recruiting NCT02533310
50 Internet-Based CBT for Children With Anxiety Disorders: Implementation in Clinical Settings Active, not recruiting NCT02350257

Search NIH Clinical Center for Phobia, Specific

Cochrane evidence based reviews: phobia, specific

Genetic Tests for Phobia, Specific

Anatomical Context for Phobia, Specific

MalaCards organs/tissues related to Phobia, Specific:

39
Brain

Publications for Phobia, Specific

Articles related to Phobia, Specific:

id Title Authors Year
1
Hypochondriasis Differs From Panic Disorder and Social Phobia: Specific Processes Identified Within Patient Groups. ( 27805984 )
2016
2
Biased attention to threat in paediatric anxiety disorders (generalized anxiety disorder, social phobia, specific phobia, separation anxiety disorder) as a function of 'distress' versus 'fear' diagnostic categorization. ( 23591000 )
2014
3
Co-morbid anxiety disorders in bipolar disorder and major depression: familial aggregation and clinical characteristics of co-morbid panic disorder, social phobia, specific phobia and obsessive-compulsive disorder. ( 22099954 )
2012

Variations for Phobia, Specific

Expression for Phobia, Specific

Search GEO for disease gene expression data for Phobia, Specific.

Pathways for Phobia, Specific

GO Terms for Phobia, Specific

Cellular components related to Phobia, Specific according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 dendritic spine GO:0043197 8.62 COMT FMR1

Biological processes related to Phobia, Specific according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 neurotransmitter catabolic process GO:0042135 9.16 COMT MAOA
2 catecholamine metabolic process GO:0006584 8.96 COMT MAOA
3 dopamine catabolic process GO:0042420 8.62 COMT MAOA

Sources for Phobia, Specific

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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