MCID: PHB003
MIFTS: 35

Phobia, Specific

Categories: Mental diseases

Aliases & Classifications for Phobia, Specific

MalaCards integrated aliases for Phobia, Specific:

Name: Phobia, Specific 53 13 41 69
Specific Phobia 12 72 14
Phobia, Simple 53
Simple Phobia 12

Classifications:



External Ids:

OMIM 53 608251
Disease Ontology 12 DOID:599
ICD10 32 F40.2
MeSH 41 C562465
NCIt 46 C35284
SNOMED-CT 64 192396001 54587008
MedGen 39 C0236801
UMLS 69 C0236801

Summaries for Phobia, Specific

Disease Ontology : 12 A phobic disorder that is characterized by an unreasonable or irrational fear related to exposure to specific objects or situations.

MalaCards based summary : Phobia, Specific, also known as specific phobia, is related to panic disorder and anxiety. An important gene associated with Phobia, Specific is PHOBS (Phobia, Specific), and among its related pathways/superpathways are Tyrosine metabolism and Neurotransmitter Clearance In The Synaptic Cleft. The drugs Citalopram and Antidepressive Agents have been mentioned in the context of this disorder. Affiliated tissues include brain.

Wikipedia : 72 A specific phobia is any kind of anxiety disorder that amounts to an unreasonable or irrational fear... more...

Description from OMIM: 608251

Related Diseases for Phobia, Specific

Diseases related to Phobia, Specific via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 panic disorder 29.5 COMT MAOA
2 anxiety 29.3 COMT MAOA
3 obsessive-compulsive disorder 29.2 COMT MAOA
4 animal phobia 11.3
5 nosophobia 11.1
6 panic disorder 1 10.9
7 williams-beuren syndrome 10.9
8 flying phobia 10.9
9 avoidant personality disorder 10.1 FMR1 MAOA
10 brunner syndrome 10.1 COMT MAOA
11 oppositional defiant disorder 10.1 COMT MAOA
12 dystonia 1, torsion, autosomal dominant 10.1 COMT MAOA
13 antisocial personality disorder 10.0 COMT MAOA
14 social phobia 10.0
15 paranoid schizophrenia 10.0 COMT MAOA
16 postpartum depression 10.0 COMT MAOA
17 early-onset schizophrenia 10.0 COMT MAOA
18 borderline personality disorder 10.0 COMT MAOA
19 mental depression 10.0 COMT MAOA
20 bulimia nervosa 1 10.0 COMT MAOA
21 conduct disorder 10.0 COMT MAOA
22 personality disorder 10.0 COMT MAOA
23 substance abuse 10.0 COMT MAOA
24 post-traumatic stress disorder 10.0 COMT MAOA
25 chronic fatigue syndrome 10.0 COMT MAOA
26 tobacco addiction 9.9 COMT MAOA
27 specific developmental disorder 9.9 COMT FMR1
28 restless legs syndrome 9.9 COMT MAOA
29 mood disorder 9.9 COMT MAOA
30 velocardiofacial syndrome 9.7
31 major depressive disorder 9.7
32 bipolar disorder 9.7
33 separation anxiety disorder 9.7
34 hypochondriasis 9.7
35 generalized anxiety disorder 9.7
36 phobic disorder 9.7 COMT MAOA NBAS
37 disease of mental health 9.7 COMT FMR1 MAOA
38 autism spectrum disorder 9.7 COMT FMR1 MAOA
39 attention deficit-hyperactivity disorder 9.7 COMT FMR1 MAOA
40 migraine with or without aura 1 9.6 COMT MAOA
41 autism 9.5 COMT FMR1 MAOA

Graphical network of the top 20 diseases related to Phobia, Specific:



Diseases related to Phobia, Specific

Symptoms & Phenotypes for Phobia, Specific

Clinical features from OMIM:

608251

Drugs & Therapeutics for Phobia, Specific

Drugs for Phobia, Specific (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Citalopram Approved Phase 2, Phase 3 59729-33-8 2771
2 Antidepressive Agents Phase 2, Phase 3
3 Antidepressive Agents, Second-Generation Phase 2, Phase 3
4 Antiparkinson Agents Phase 2, Phase 3
5 Autonomic Agents Phase 2, Phase 3
6 Cholinergic Agents Phase 2, Phase 3
7 Cholinergic Antagonists Phase 2, Phase 3
8 Muscarinic Antagonists Phase 2, Phase 3
9 Neurotransmitter Agents Phase 2, Phase 3
10 Neurotransmitter Uptake Inhibitors Phase 2, Phase 3
11 Parasympatholytics Phase 2, Phase 3
12 Peripheral Nervous System Agents Phase 2, Phase 3
13 Psychotropic Drugs Phase 2, Phase 3
14
Serotonin Phase 2, Phase 3 50-67-9 5202
15 Serotonin Agents Phase 2, Phase 3
16 Serotonin Uptake Inhibitors Phase 2, Phase 3
17
Cycloserine Approved Phase 2,Phase 1 68-41-7 6234 401
18
Valproic Acid Approved, Investigational Phase 2 99-66-1 3121
19 Anti-Bacterial Agents Phase 2,Phase 1
20 Antibiotics, Antitubercular Phase 2,Phase 1
21 Anti-Infective Agents Phase 2,Phase 1
22 Antimetabolites Phase 2,Phase 1
23 Antitubercular Agents Phase 2,Phase 1
24 Renal Agents Phase 2,Phase 1
25 Anti-Anxiety Agents Phase 2
26 Antipsychotic Agents Phase 2
27 Central Nervous System Depressants Phase 2
28 Quetiapine Fumarate Phase 2 111974-72-2
29 Tranquilizing Agents Phase 2
30 Anticonvulsants Phase 2
31 Antimanic Agents Phase 2
32 GABA Agents Phase 2
33 Pharmaceutical Solutions Phase 2
34
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
35
Midazolam Approved, Illicit 59467-70-8 4192
36
Nitrous oxide Approved, Vet_approved 10024-97-2 948
37
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
38 tannic acid Approved, Nutraceutical
39
Imidacloprid Vet_approved 105827-78-9 86418
40 Contraceptive Agents
41 Estradiol 17 beta-cypionate
42 Estradiol 3-benzoate
43 Estradiol valerate 979-32-8
44 Estrogens
45 Hormone Antagonists
46 Hormones
47 Hormones, Hormone Substitutes, and Hormone Antagonists
48 Polyestradiol phosphate
49 Complement System Proteins
50 Anesthetics

Interventional clinical trials:

(show top 50) (show all 54)

# Name Status NCT ID Phase Drugs
1 Study of Escitalopram in the Treatment of Specific Phobia Completed NCT00121069 Phase 2, Phase 3 Escitalopram
2 Virtual Reality Exposure Therapy in Agoraphobic Participants Completed NCT00734370 Phase 2, Phase 3
3 Psychotherapy for Anxiety in Children With Autism Spectrum Disorder Active, not recruiting NCT02028247 Phase 3
4 Treatment Study for Rural Latino Youth With Anxiety Unknown status NCT01491880 Phase 1, Phase 2
5 Quetiapine in Specific Phobia Completed NCT00872716 Phase 2 Quetiapine XR
6 Treatment for Specific Phobias in Children Completed NCT00051220 Phase 1, Phase 2
7 fMRI Study Examining Effects of D-cycloserine in Specific Phobia Completed NCT00591825 Phase 2 D-cycloserine;Placebo
8 D-cycloserine and Treatment of Feeding Disorders Completed NCT01923896 Phase 1, Phase 2 d-cycloserine (DCS);Placebo
9 Brief Behavioral Treatment for Anxiety in Young Children Completed NCT02051192 Phase 1, Phase 2
10 Influence of Valproic Acid on Extinction-based Therapy in Patients With Fear of Spiders. Recruiting NCT02789813 Phase 2 Valproic Acid;Placebo
11 Enhancing Exposure Therapy for Snake and Spider Phobias Active, not recruiting NCT02160470 Phase 1, Phase 2
12 The Modular Protocol for Mental Health (MPMH) Enrolling by invitation NCT03143634 Phase 1, Phase 2
13 Intervention for Anxiety After Falls Completed NCT01268657 Phase 1
14 Time Intensive CBT for a Specific Phobia of Vomiting Recruiting NCT02920814 Phase 1
15 D-Cycloserine-Enhancer of One-Session Treatment for Phobia of Heights Unknown status NCT01037101 D-Cycloserine;Placebo
16 Cognitive Behavioural Treatment of Intra-oral Injection-phobia in 10-16 Year Old Children and Adolescents Unknown status NCT02083432
17 Parent-Augmented Cognitive Behavioral Therapy to Treat Children With Specific Phobias Completed NCT00509951
18 The Impact of Sex Hormones on One-session Treatment for Spider Phobia in Women Completed NCT02622087
19 Study of Brain Circuitry in Anxiety Disorders Completed NCT01849432
20 The Effects of Safety Seeking Behaviors During Exposure Therapy for Adults With Spider Phobia Completed NCT03233113
21 Extinction Generalization in Exposure Therapy Completed NCT03031002
22 Validity of a Self-administered Questionnaire to Screen Phobia of Falling in the Elderly Completed NCT02387047
23 Exposure, D-cycloserine Enhancement, and Functional Magnetic Resonance Imaging (fMRI) in Snake Phobics Completed NCT01450306 D-cycloserine;Placebo
24 Internet-delivered Treatment for Children With Anxiety Disorders in a Rural Area; an Open Trial in a Clinical Setting Completed NCT02306356
25 In Vivo Versus Augmented Reality Exposure for Small Animal Phobia Completed NCT01361074
26 Internet-delivered Cognitive Behavior Therapy (CBT) for Children Age 8-12 Years With Anxiety Disorders Completed NCT01533402
27 Clinical Management of Anxiety and Access to Health Care Completed NCT02081365
28 Changes in Brain Activity (Functional MRI Study) Before and After Behavioral Therapy of Height Phobia Completed NCT00302978
29 Exposure-Focused Family-Based CBT for Youth With ASD and Comorbid Anxiety Completed NCT01919970
30 EMDR in Spider Phobia: Work Mechanisms and Treatment Outcome Completed NCT02973919
31 Children and Adolescents With Dental Anxiety - Randomized Controlled Study of Cognitive Behavioral Therapy Completed NCT01798355
32 Online, Guided Interventions to Reduce Generalized Anxiety Disorder Among Indian University Students Completed NCT02410265
33 How to Act on the Mobility Restriction Linked to Senior's Phobia of Falling Recruiting NCT02554838
34 Self-efficacy Enhancement and Exposure Therapy Recruiting NCT03105024
35 Anti-phobic and Safety Behaviors in the Treatment of Acrophobia Recruiting NCT02085343
36 Spider Phobia Opposite Action Treatment Study Recruiting NCT02905279
37 tDCS-Augmented Exposure Therapy for Pathological Fear Recruiting NCT03095482
38 Providing Tools for Effective Care and Treatment of Anxiety Disorders Recruiting NCT02605668
39 Transdiagnostic REBT Prevention Program for Adolescents Recruiting NCT02756507
40 Building an Outcomes Assessment Infrastructure to Assess Anxiety Treatment Recruiting NCT02305537
41 Internet-delivered Transdiagnostic Intervention for Anxiety and Depression Recruiting NCT02739607
42 Effect of Mindfulness Meditation on Physiological Response to Unpredictable Stimuli Recruiting NCT03206437
43 Dimensional Brain Behavior Predictors of CBT Outcomes in Pediatric Anxiety Recruiting NCT02810171
44 Internet-Based Cognitive Behavioral Therapy for Children With Dental Anxiety Recruiting NCT02588079
45 Treating Emotional Disorders in Primary Care With Psychological Techniques Recruiting NCT01903096 Primary Care Treatment As Usual
46 Virtual Reality Immersive Method for Spider (Phobia) Exposure Therapy (VIMSE) Active, not recruiting NCT02533310
47 Internet-Based CBT for Children With Anxiety Disorders: Implementation in Clinical Settings Active, not recruiting NCT02350257
48 A Randomised Feasibility Trial With Internet Based Self-help Therapy Active, not recruiting NCT02499055
49 Outcomes of Cognitive Behavioral Therapy (CBT) Interventions Provided by Unlicensed Professionals Active, not recruiting NCT01075672
50 Attention Bias Modification Treatment for Anxious Youth Active, not recruiting NCT01979263

Search NIH Clinical Center for Phobia, Specific

Cochrane evidence based reviews: phobia, specific

Genetic Tests for Phobia, Specific

Anatomical Context for Phobia, Specific

MalaCards organs/tissues related to Phobia, Specific:

38
Brain

Publications for Phobia, Specific

Articles related to Phobia, Specific:

# Title Authors Year
1
Hypochondriasis Differs From Panic Disorder and Social Phobia: Specific Processes Identified Within Patient Groups. ( 27805984 )
2016
2
Biased attention to threat in paediatric anxiety disorders (generalized anxiety disorder, social phobia, specific phobia, separation anxiety disorder) as a function of 'distress' versus 'fear' diagnostic categorization. ( 23591000 )
2014
3
Co-morbid anxiety disorders in bipolar disorder and major depression: familial aggregation and clinical characteristics of co-morbid panic disorder, social phobia, specific phobia and obsessive-compulsive disorder. ( 22099954 )
2012

Variations for Phobia, Specific

Expression for Phobia, Specific

Search GEO for disease gene expression data for Phobia, Specific.

Pathways for Phobia, Specific

GO Terms for Phobia, Specific

Cellular components related to Phobia, Specific according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendritic spine GO:0043197 8.62 COMT FMR1

Biological processes related to Phobia, Specific according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neurotransmitter catabolic process GO:0042135 9.16 COMT MAOA
2 catecholamine metabolic process GO:0006584 8.96 COMT MAOA
3 dopamine catabolic process GO:0042420 8.62 COMT MAOA

Sources for Phobia, Specific

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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