MCID: PHB001
MIFTS: 32

Phobic Disorder malady

Mental diseases category

Summaries for Phobic Disorder

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Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
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Wikipedia:66 A phobia (from the Greek: ????? ph more...

MalaCards: Phobic Disorder, also known as phobic anxiety disorder, is related to agoraphobia and panic disorder. An important gene associated with Phobic Disorder is TMPO (thymopoietin), and among its related pathways is RNA Polymerase I Promoter Opening. The drugs gabapentin and paroxetine and the compounds inositol 1,4,5 trisphosphate and acth have been mentioned in the context of this disorder.

Disease Ontology:9 An anxiety disorder where fear and anxiety are triggered by a specific stimulus or situation.

Aliases & Classifications for Phobic Disorder

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9Disease Ontology, 63UMLS, 59SNOMED-CT, 28ICD9CM, 36MeSH, 41NCIt, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

phobic disorder 9
phobic anxiety disorder 63


Related Diseases for Phobic Disorder

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Phobic Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 13)
idRelated DiseaseScoreTop Affiliating Genes
1agoraphobia10.1
2panic disorder10.1
3anorexia nervosa10.1
4social phobia10.1
5alcohol dependence10.1
6anxiety disorder10.1
7specific phobia10.1
8substance dependence10.1
9congenital fibrosarcoma10.0GOLGA6B, GOLGA6A
10atopic dermatitis10.0BDNF, TMPO
11rheumatoid arthritis10.0BDNF, TMPO
12herpes simplex10.0TMPO, BDNF
13multiple sclerosis9.9BDNF, TMPO

Graphical network of diseases related to Phobic Disorder:



Diseases related to phobic disorder

Symptoms for Phobic Disorder

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Drugs & Therapeutics for Phobic Disorder

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Phobic Disorder

Drug clinical trials:

Search ClinicalTrials for Phobic Disorder

Search NIH Clinical Center for Phobic Disorder

Search CenterWatch for Phobic Disorder

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Phobic Disorder

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Anatomical Context for Phobic Disorder

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Animal Models for Phobic Disorder or affiliated genes

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Publications for Phobic Disorder

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Sources:
53PubMed
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Articles related to Phobic Disorder:

(show all 12)
idTitleAuthorsYear
1
Validation of the diagnoses of panic disorder and phobic disorders in the US National Comorbidity Survey Replication Adolescent (NCS-A) supplement. (21495110)
2011
2
Genetic association between BDNF gene polymorphisms and phobic disorders: a case-control study among mainland Han Chinese. (21295349)
2011
3
The effectiveness of anxiety treatment on alcohol-dependent patients with a comorbid phobic disorder: a randomized controlled trial. (15897725)
2005
4
Temporal relationship between the age of onset of phobic disorders and development of substance dependence in adolescent psychiatric patients. (15283954)
2004
5
A polymorphic genomic duplication on human chromosome 15 is a susceptibility factor for panic and phobic disorders. (11509185)
2001
6
Social and personal resources and the prevalence of phobic disorder in a community population. (10883724)
2000
7
The longitudinal study of phobic disorder in a community sample from early to late adolescence. (11018436)
2000
8
Phobic disorder, psychotherapy, and risk-taking: an economic perspective. (10180917)
1998
9
Frequency of phobic disorder in a community sample of young adolescents. (7559315)
1995
10
Role of thymic hormones in neuroimmunomodulation. Their use in patients with phobic disorders. (1776534)
1991
11
Administration of thymopentin to patients with phobic disorders improves depressed phagocytic functions. (2092042)
1990
12
Is anorexia nervosa a phobic disorder? A psychophysiological enquiry. (7417632)
1980

Variations for Phobic Disorder

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Expression for genes affiliated with Phobic Disorder

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Phobic Disorder

Search GEO for disease gene expression data for Phobic Disorder.

Pathways for genes affiliated with Phobic Disorder

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Sources:
51PathCards, 56Reactome, 31KEGG
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Compounds for genes affiliated with Phobic Disorder

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Sources:
46Novoseek, 30IUPHAR, 62Tocris Bioscience, 12DrugBank
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Compounds related to Phobic Disorder according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1inositol 1,4,5 trisphosphate469.4BDNF, TMPO
2acth469.3BDNF, TMPO
3aspartate469.3BDNF, TMPO
4indomethacin46 30 62 1212.2TMPO, BDNF
5methionine469.0BDNF, TMPO

GO Terms for genes affiliated with Phobic Disorder

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Sources:
17Gene Ontology
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Cellular components related to Phobic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi apparatusGO:0057949.1GOLGA6B, GOLGA6A

Products for genes affiliated with Phobic Disorder

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Phobic Disorder

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet