MCID: PHY007
MIFTS: 41

Phyllode Tumor malady

Reproductive, Cancer categories

Summaries for Phyllode Tumor

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33MalaCards
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MalaCards: Phyllode Tumor, also known as cystosarcoma phylloide, is related to breast malignant phyllodes tumor and adenocarcinoma. An important gene associated with Phyllode Tumor is NEK8 (NIMA-related kinase 8), and among its related pathways are Cardiac Progenitor Differentiation and Hematopoietic cell lineage. The compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Affiliated tissues include lung, thyroid and breast, and related mouse phenotypes are muscle and integument.

Aliases & Classifications for Phyllode Tumor

Sources:
49Orphanet, 61UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 62UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Reproductive


Aliases & Descriptions:

phyllode tumor 49
cystosarcoma phylloide 49
cystosarcoma phyllode 49
phyllodes tumor 61
phylloide tumor 49


External Ids:

MESH via Orphanet36 D003557
ICD10 via Orphanet26 D24
UMLS via Orphanet62 C0010701

Related Diseases for Phyllode Tumor

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Phyllode Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1breast malignant phyllodes tumor31.1NEK8
2adenocarcinoma30.6VIM, CCNA2, PIP, CGB, MKI67, CD34
3fibromatosis30.4VIM, CD34, PGR, KIT, ACTC1
4desmoid tumor30.4KIT, ACTC1
5cribriform carcinoma30.1PGR, KIT
6spindle cell carcinoma30.1VIM, PGR, ACTC1
7angiosarcoma30.1ACTC1, CD34, VIM
8adenoma30.1CCNA2, CGB, IGF2, MKI67, ACTC1, ACPP
9benign prostate phyllodes tumor10.5
10benign breast phyllodes tumor10.5
11hypoglycemia10.3
12breast osteosarcoma10.3
13scirrhous adenocarcinoma10.3
14breast adenocarcinoma10.3
15soft tissue sarcoma10.3
16prostate malignant phyllodes tumor10.2
17infantile digital fibromatosis10.2
18pseudoangiomatous stromal hyperplasia10.2
19neurofibromatosis10.1
20hypoglycemic coma10.1
21inflammatory breast carcinoma10.1
22intussusception10.1
23breast angiosarcoma10.1
24thyroid adenoma10.1
25uterine carcinosarcoma10.0KIT
26giant cell tumor10.0ACPP
27cystadenoma10.0MME
28prostatitis10.0ACPP
29ductal carcinoma in situ10.0PGR
30germ cell tumors10.0KIT
31chordoma10.0VIM
32histiocytosis10.0ACPP
33oligodendroglioma10.0MKI67
34paraganglioma10.0KIT
35lymphangioleiomyomatosis10.0PGR
36gonadoblastoma10.0KIT
37malignant mesothelioma10.0VIM
38kaposi's sarcoma10.0CD34
39chondrosarcoma10.0VIM
40pheochromocytoma10.0CCNA2
41leiomyomatosis10.0PGR
42papilloma10.0ACTC1
43gynecomastia10.0PGR
44lipoma10.0CD34
45progesterone resistance10.0PGR
46breast cyst10.0PIP
47germ cell cancer10.0ESR2
48fasciitis10.0ACTC1
49sertoli cell tumor10.0VIM, PGR
50mastocytosis10.0KIT

Graphical network of the top 20 diseases related to Phyllode Tumor:



Diseases related to phyllode tumor

Clinical Features for Phyllode Tumor

Drugs & Therapeutics for Phyllode Tumor

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Phyllode Tumor

Search NIH Clinical Center for Phyllode Tumor

Search CenterWatch for Phyllode Tumor

Genetic Tests for Phyllode Tumor

Anatomical Context for Phyllode Tumor

Sources:
33MalaCards
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MalaCards organs/tissues related to Phyllode Tumor:

33
Lung, Thyroid, Breast, Prostate, B cells

Animal Models for Phyllode Tumor or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Phyllode Tumor:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.8IGF2, ACTC1, ESR2, CEBPB
2MP:00107719.7CEBPB, IGF2, CD34, HOXB13, MME, ACPP
3MP:00053769.4NEK8, IGF2, CD34, PGR, ACTC1, CEBPB
4MP:00053879.3CCNA2, IGF2, CD34, PGR, MME, KIT
5MP:00053849.2VIM, CCNA2, IGF2, CD34, HOXB13, PGR

Publications for Phyllode Tumor

Sources:
51PubMed
See all sources

Articles related to Phyllode Tumor:

(show top 50)    (show all 60)
idTitleAuthorsYear
1
Collision tumor with inflammatory breast carcinoma and malignant phyllodes tumor: a case report and literature review. (24400686)
2014
2
Phyllodes Tumor in Survivors of Childhood Osteosarcoma: A Single Institution's Experience. (24065044)
2014
3
A TP53 founder mutation, p.R337H, is associated with phyllodes breast tumors in Brazil. (23794094)
2013
4
Ubiquitin carboxy-terminal hydrolase L1 may be involved in the development of mammary phyllodes tumors. (23291960)
2013
5
First case of transformation for breast fibroadenoma to high-grade malignant phyllodes tumor in an in vitro fertilization patient: misdiagnosis of recurrence, treatment and review of the literature. (24089229)
2013
6
Phyllodes tumor of the breast: role of CD10 in predicting metastasis. (22006372)
2012
7
Hormone receptors expression in phyllodes tumors of the breast. (22590818)
2012
8
Jejunal intussusception due to malignant phyllodes tumor of the breast. (22381472)
2012
9
Anemia and jejunal intussusception: An unusual presentation for a metastatic phyllodes breast tumor. (22288047)
2012
10
E-cadherin expression in the epithelial components of mammary phyllodes tumors. (22820000)
2012
11
Keratin 15, transcobalamin I and homeobox gene Hox-B13 expression in breast phyllodes tumors: novel markers in biological classification. (21574054)
2012
12
Angiosarcoma in recurrent malignant phyllodes tumor of breast. (22771666)
2012
13
Recurrent Mastitis after Core Needle Biopsy: Case Report of an Unusual Complication after Core Needle Biopsy of a Phyllodes Tumor. (22872800)
2012
14
Ductal carcinoma in situ arising within a benign phyllodes tumor: A case report with a review of the literature. (22866068)
2011
15
Delayed cardiac metastasis from phyllodes breast tumor presenting as cardiogenic shock. (21841880)
2011
16
Malignant transformation of breast fibroadenoma to malignant phyllodes tumor: long-term outcome of 36 malignant phyllodes tumors. (22121516)
2011
17
c-Kit expression and mutations in phyllodes tumors of the breast. (21115932)
2010
18
Fibroadenoma and phyllodes tumors of anogenital mammary-like glands: a series of 13 neoplasms in 12 cases, including mammary-type juvenile fibroadenoma, fibroadenoma with lactation changes, and neurofibromatosis-associated pseudoangiomatous stromal hyperplasia with multinucleated giant cells. (20035149)
2010
19
Loss of SDHB and NF1 genes in a malignant phyllodes tumor of the breast as detected by oligo-array comparative genomic hybridization. (20082856)
2010
20
Expression of anaphase-promoting complex7 in fibroadenomas and phyllodes tumors of breast. (18789487)
2009
21
Molecular pathogenesis of progression and recurrence in breast phyllodes tumors. (19966935)
2009
22
An approach to malignant mammary phyllodes tumors detection. (19441158)
2009
23
Beta-human chorionic gonadotropin production associated with phyllodes tumor of the breast: an unusual paraneoplastic phenomenon. (19624411)
2009
24
Borderline and malignant phyllodes tumors display similar promoter methylation profiles. (19924440)
2009
25
Increased epidermal growth factor receptor (EGFR) expression in malignant mammary phyllodes tumors. (18443904)
2009
26
Benign phyllodes tumor of the breast with intracytoplasmic inclusion bodies identical to infantile digital fibromatosis. (18266786)
2008
27
Association of the BRCA1 missense variant R1699W with a malignant phyllodes tumor of the breast. (17574969)
2007
28
Hypoglycemic coma secondary to big insulin-like growth factor II secretion by a giant phyllodes tumor of the breast. (17319862)
2007
29
Amplifications of EGFR gene and protein expression of EGFR, Her-2/neu, c-kit, and androgen receptor in phyllodes tumor of the prostate. (17192792)
2007
30
Malignant phyllode tumor metastatic to the duodenum. (16570365)
2006
31
Phyllodes tumor: a clinicopathologic and immunohistochemical study of 30 cases. (17090194)
2006
32
CD10, actin, and vimentin expression in breast phyllodes tumors correlates with tumor grades of the WHO grading system. (16703173)
2006
33
Estrogen receptor-beta is expressed in stromal cells of fibroadenoma and phyllodes tumors of the breast. (16554735)
2006
34
Amplifications of the epidermal growth factor receptor gene (egfr) are common in phyllodes tumors of the breast and are associated with tumor progression. (16258523)
2006
35
p53 and c-kit (CD117) protein expression as prognostic indicators in breast phyllodes tumors: a tissue microarray study. (16258510)
2005
36
Progressive deregulation of the cell cycle with higher tumor grade in the stroma of breast phyllodes tumors. (15981808)
2005
37
Increased c-kit (CD117) expression in malignant mammary phyllodes tumors. (15044924)
2004
38
Phyllodes tumor of the prostate: long-term followup study of 23 cases. (15310992)
2004
39
Expression of p53 protein and Ki-67 antigen in phyllodes tumor of the breast. (15077883)
2004
40
Characterization of lesions of the breast with proton MR spectroscopy: comparison of carcinomas, benign lesions, and phyllodes tumors. (14573418)
2003
41
Proliferating activity in differential diagnosis of benign phyllodes tumor and cellular fibroadenomas: is it helpful? (11692149)
2001
42
Prognostic evaluation of proliferative activity and DNA content in the phyllodes tumor of the breast: immunohistochemical and flow cytometric study of 118 cases. (11245343)
2001
43
p53 protein expression and gene mutation in phyllodes tumors of the breast. (11314782)
2001
44
Malignant phyllodes tumor of the breast with expression of osteonectin and vinculin. (11350610)
2001
45
Platelet-derived growth factor expression in phyllodes tumors and fibroadenomas of the breast. (11070114)
2000
46
CD34, CD117, and actin expression in phyllodes tumor of the breast. (11104647)
2000
47
Malignant phyllodes tumor of breast with lung metastases mimicking the primary. (9777991)
1998
48
Progression of fibroadenoma to phyllodes tumor demonstrated by clonal analysis. (8625047)
1995
49
Phyllodes tumor of the breast containing the intracytoplasmic inclusion bodies identical with infantile digital fibromatosis. (8172324)
1994
50
Desmoid tumor associated with cystosarcoma phyllodes of the breast. (175220)
1976

Genetic Variations for Phyllode Tumor

Expression for genes affiliated with Phyllode Tumor

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Phyllode Tumor

Search GEO for disease gene expression data for Phyllode Tumor.

Pathways for genes affiliated with Phyllode Tumor

Sources:
38NCBI BioSystems Database, 30KEGG, 4Cell Signaling Technology, 52QIAGEN
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Compounds for genes affiliated with Phyllode Tumor

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Phyllode Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.8MME
2estrogen4510.8ACPP
3paclitaxel45 50 1112.5CCNA2, IGF2, PGR
42-methoxyethanol4510.5ACTC1, IGF2, VIM
5anastrozole45 1111.4IGF2, MKI67, PGR
6dexamethasone45 50 29 1113.4CCNA2, IGF2, MME, CEBPB
7reticulin4510.4VIM, CD34, ACTC1
8mucicarmine4510.4VIM, PIP, ACTC1
9exemestane50 45 60 1113.4IGF2, PGR, ESR2
104-hydroxytamoxifen4510.3ESR2, PGR, IGF2, VIM
11irinotecan45 50 1112.3KIT, MKI67, IGF2, CCNA2
12methylcellulose4510.3ACPP, KIT, CD34, IGF2
13gefitinib45 50 1112.3VIM, IGF2, KIT, ESR2
14glucose4510.3CGB, IGF2, ACTC1, CEBPB
15vincristine45 50 1112.3VIM, CCNA2, CGB, MKI67, KIT
16mifepristone45 60 29 1113.2CCNA2, CGB, MKI67, PGR, ESR2
17fluorochrome4510.2KIT, CD34, VIM
18progestins4510.2ESR2, PGR, MKI67, IGF2, PIP
19dihydrotestosterone45 29 11 2413.2VIM, PIP, PGR, ACPP, ESR2
20androstenedione45 2411.2PIP, CGB, IGF2, ACPP, ESR2
215fluorouracil4510.2KIT, PGR, MKI67, IGF2, CCNA2
22progestin4510.2VIM, IGF2, PGR, ESR2
23methotrexate45 50 1112.2VIM, CCNA2, CGB, MKI67, PGR, KIT
24ribonucleic acid4510.2IGF2, PGR, MME, KIT, ACTC1, ESR2
25serine4510.2ESR2, ACPP, MKI67, CCNA2
26clomiphene citrate4510.2ESR2, PGR, CGB
27steroid4510.1CCNA2, PIP, MKI67, MME, ACTC1, ACPP
28actinomycin d4510.1VIM, IGF2, MME, KIT, ESR2, CEBPB
29hematoxylin4510.1ACPP, ACTC1, KIT, CD34, MKI67, VIM
30doxorubicin45 50 1112.1VIM, CCNA2, MKI67, PGR, MME, KIT
31agar4510.1ACPP, PGR, CD34, IGF2, VIM
32glycogen45 2411.0VIM, CCNA2, IGF2, MKI67, KIT, ACTC1
33tamoxifen45 50 29 1113.0VIM, CCNA2, PIP, IGF2, MKI67, PGR
34lactate4510.0VIM, CGB, IGF2, MKI67, MME, KIT
35adenylate4510.0VIM, CCNA2, IGF2, PGR, MME, ESR2
36fulvestrant45 50 29 1113.0ESR2, PGR, MKI67
37creatinine4510.0CGB, IGF2, MME, ACTC1, ACPP
38thymidine45 2411.0CCNA2, IGF2, MKI67, CD34, MME, KIT
39gnrh459.9VIM, CGB, IGF2, MKI67, PGR, MME
40etoposide45 50 60 1112.9VIM, CCNA2, CGB, IGF2, ESR2
41arginine459.8VIM, CCNA2, IGF2, MKI67, MME, ACPP
4212-o-tetradecanoylphorbol 13-acetate459.8CEBPB, MME, CD34, CCNA2, VIM
43estradiol45 11 2411.6VIM, CCNA2, PIP, CGB, IGF2, MKI67
44indomethacin45 60 29 1112.6VIM, IGF2, PGR, MME, CEBPB
45tyrosine459.5CD34, MKI67, IGF2, CCNA2, MME, KIT
46vegf459.4MKI67, IGF2, CGB, CCNA2, VIM, CD34
47paraffin459.4VIM, ESR2, ACPP, ACTC1, CCNA2, PIP
48retinoic acid45 2410.4CD34, MKI67, IGF2, CCNA2, VIM, PGR
49testosterone45 60 11 2412.3VIM, CCNA2, PIP, CGB, IGF2, MKI67
50progesterone45 60 29 11 2413.1PGR, MME, KIT, ACTC1, ACPP, ESR2

GO Terms for genes affiliated with Phyllode Tumor

Sources:
16Gene Ontology
See all sources

Biological processes related to Phyllode Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epithelial cell maturation involved in prostate gland developmentGO:06074310.2ESR2, HOXB13

Products for genes affiliated with Phyllode Tumor

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Sources for Phyllode Tumor

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet