MCID: PHY007
MIFTS: 37

Phyllode Tumor malady

Categories: Reproductive diseases, Rare diseases

Aliases & Classifications for Phyllode Tumor

Aliases & Descriptions for Phyllode Tumor:

Name: Phyllode Tumor 56
Phyllodes Tumor 52 69
Cystosarcoma Phylloide 56
Cystosarcoma Phyllode 56
Phylloide Tumor 56

Characteristics:

Orphanet epidemiological data:

56
phyllode tumor
Age of onset: Adult;

Classifications:



External Ids:

Orphanet 56 ORPHA180261
ICD10 via Orphanet 34 D48.6
MESH via Orphanet 43 D003557
UMLS via Orphanet 70 C0010701

Summaries for Phyllode Tumor

MalaCards based summary : Phyllode Tumor, also known as phyllodes tumor, is related to breast malignant phyllodes tumor and benign breast phyllodes tumor. An important gene associated with Phyllode Tumor is PGR (Progesterone Receptor), and among its related pathways/superpathways are DNA Damage and B Cell Development Pathways. The drugs Fluorouracil and Belinostat have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and thyroid, and related phenotypes are Increased viability after TNF/CHX stimulation and embryo

Wikipedia : 71 Phyllodes tumors (from Greek: phullon leaf), also cystosarcoma phyllodes, cystosarcoma phylloides and... more...

Related Diseases for Phyllode Tumor

Diseases related to Phyllode Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
id Related Disease Score Top Affiliating Genes
1 breast malignant phyllodes tumor 12.4
2 benign breast phyllodes tumor 12.1
3 benign prostate phyllodes tumor 12.0
4 prostate malignant phyllodes tumor 11.9
5 li-fraumeni syndrome 11.1
6 skin angiosarcoma 10.3 KIT PGR
7 intestinal neuroendocrine benign tumor 10.3 KIT PGR
8 vulva basal cell carcinoma 10.3 KIT PGR
9 middle ear adenocarcinoma 10.3 KIT PGR
10 common bile duct neoplasm 10.3 MKI67 PGR
11 papilloma 10.3 MME PGR
12 panophthalmitis 10.2 MME PGR
13 ovarian embryonal carcinoma 10.2 KIT PGR
14 vaginal adenosarcoma 10.2 MME PGR
15 postpartum depression 10.2 KIT PGR
16 pustulosis palmaris et plantaris 10.2 KIT MKI67
17 paranasal sinus cancer 10.2 KIT MME
18 reactive arthritis 10.2 KIT PGR
19 gastric leiomyosarcoma 10.2 IGF2 KIT
20 prostate leiomyosarcoma 10.2 IGF2 KIT
21 lymphomatous thyroiditis 10.2 PGR VIM
22 sphenoid sinus squamous cell carcinoma 10.2 KIT MME
23 male reproductive organ benign neoplasm 10.2 MME PGR
24 adult endodermal sinus tumor 10.2 PGR VIM
25 central nervous system primitive neuroectodermal neoplasm 10.2 MME PGR
26 endometrial stromal sarcoma 10.2 PGR VIM
27 biemond syndrome 10.2 PGR VIM
28 deafness, autosomal recessive 74 10.2 IGF2 PGR
29 larynx leiomyosarcoma 10.2 IGF2 KIT
30 trachea sarcoma 10.2 MME PGR
31 gallbladder cancer 10.2 KIT MME
32 intracranial sinus thrombosis 10.2 KIT VIM
33 factitious disorder 10.2 KIT MME
34 diffuse glomerulonephritis 10.2 IGF2 KIT
35 cranial nerve disease 10.2 KIT MME
36 alcohol-induced mental disorder 10.2 KIT VIM
37 retinal vein occlusion 10.2 KIT MME
38 t-cell adult acute lymphocytic leukemia 10.2 MME PGR
39 stomach diverticulosis 10.2 KIT VIM
40 diphtheria 10.2 IGF2 PGR
41 lung clear cell carcinoma 10.2 MME PGR
42 subependymal glioma 10.2 MKI67 VIM
43 lymphangiosarcoma 10.2 MME VIM
44 foix-alajouanine syndrome 10.2 CCNA2 MKI67
45 pneumonia 10.1 KIT PGR
46 mucinous tubular and spindle renal cell carcinoma 10.1 MME VIM
47 epidural abscess 10.1 IGF2 PGR
48 central nervous system tuberculosis 10.1 MKI67 MME PGR
49 gastrointestinal system cancer 10.1 PGR VIM
50 struma ovarii 10.1 MKI67 MME PGR

Graphical network of the top 20 diseases related to Phyllode Tumor:



Diseases related to Phyllode Tumor

Symptoms & Phenotypes for Phyllode Tumor

GenomeRNAi Phenotypes related to Phyllode Tumor according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability after TNF/CHX stimulation GR00228-A 8.62 ACPP KIT

MGI Mouse Phenotypes related to Phyllode Tumor:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.8 PGR TP63 VIM CCNA2 IGF2 KIT
2 immune system MP:0005387 9.8 MME PGR TP63 VIM CCNA2 IGF2
3 integument MP:0010771 9.63 MME PGR TP63 ACPP IGF2 KIT
4 muscle MP:0005369 9.35 KIT PGR TP63 VIM IGF2
5 reproductive system MP:0005389 9.1 KIT PGR TP63 VIM ACPP IGF2

Drugs & Therapeutics for Phyllode Tumor

Drugs for Phyllode Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 1 51-21-8 3385
2
Belinostat Approved, Investigational Phase 1 866323-14-0
3 Histone Deacetylase Inhibitors Phase 1
4 Androgens Phase 1
5 Immunosuppressive Agents Phase 1
6 Antimetabolites Phase 1
7 Antimetabolites, Antineoplastic Phase 1
8
Lidocaine Approved, Vet_approved 137-58-6 3676
9 Sodium Channel Blockers
10 Anesthetics
11 Disinfectants
12 Diuretics, Potassium Sparing
13 Peripheral Nervous System Agents
14 Anesthetics, Local
15 Pharmaceutical Solutions
16 Anti-Arrhythmia Agents
17 Central Nervous System Depressants
18 Calamus Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase
1 Radiation Therapy After Surgery in Treating Women With Phyllodes Tumor of the Breast Active, not recruiting NCT00003404 Phase 2
2 Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors Completed NCT00413322 Phase 1
3 Phyllodes Tumor Partial Breast Radiation Study Recruiting NCT01089374
4 Establishing Technique for PECS2 Catheter Insertion Active, not recruiting NCT03030677

Search NIH Clinical Center for Phyllode Tumor

Genetic Tests for Phyllode Tumor

Anatomical Context for Phyllode Tumor

MalaCards organs/tissues related to Phyllode Tumor:

39
Breast, Prostate, Thyroid, Lung

Publications for Phyllode Tumor

Articles related to Phyllode Tumor:

(show top 50) (show all 81)
id Title Authors Year
1
In phyllodes tumors of the breast expression of SPARC (osteonectin/BM40) mRNA by in situ hybridization correlates with protein expression by immunohistochemistry and is associated with tumor progression. ( 27909812 )
2017
2
Loss of imprinting of IGF2 in fibroadenomas and phyllodes tumors of the breast. ( 26676988 )
2016
3
Expression of CAF-Related Proteins Is Associated with Histologic Grade of Breast Phyllodes Tumor. ( 27881889 )
2016
4
IMP3 Is Strongly Expressed in Malignant Phyllodes Tumors of the Breast: An Immunohistochemical Study. ( 26353850 )
2016
5
A Case of Giant Borderline Phyllodes Tumor of the Breast Associated with Hypoglycemia. ( 27628602 )
2016
6
Frequency of MED12 mutations in phyllodes tumors: Inverse correlation with histologic grade. ( 26856273 )
2016
7
Recurrent angio-fibroma of breast masquerading as phyllodes tumor. ( 26458623 )
2015
8
CD117 expression in breast phyllodes tumors correlates with adverse pathologic parameters and reduced survival. ( 25216225 )
2015
9
Mutational analysis of MED12 in fibroadenomas and phyllodes tumors of the breast by means of targeted next-generation sequencing. ( 26093648 )
2015
10
Liposarcoma of the breast arising in a malignant phyllodes tumor: A case report and review of the literature. ( 26468454 )
2015
11
Pleomorphic liposarcoma arising in a malignant phyllodes tumor of breast: A rare occurrence. ( 26881623 )
2015
12
C-kit overexpression correlates with KIT gene copy numbers increases in phyllodes tumors of the breast. ( 25534827 )
2015
13
Distribution of MED12 mutations in fibroadenomas and phyllodes tumors of the breast--implications for tumor biology and pathological diagnosis. ( 25931199 )
2015
14
MED12 exon 2 mutations in phyllodes tumors of the breast. ( 25865354 )
2015
15
Next-Gen Sequencing Exposes Frequent MED12 Mutations and Actionable Therapeutic Targets in Phyllodes Tumors. ( 25593300 )
2015
16
TERT promoter mutations are frequent and show association with MED12 mutations in phyllodes tumors of the breast. ( 26355235 )
2015
17
Collision tumor with inflammatory breast carcinoma and malignant phyllodes tumor: a case report and literature review. ( 24400686 )
2014
18
miR-21 induces myofibroblast differentiation and promotes the malignant progression of breast phyllodes tumors. ( 24980553 )
2014
19
Nuclear survivin expression in stromal cells of phyllodes tumors and fibroadenomas of the breast. ( 24596368 )
2014
20
Expression of Yes-associated protein (YAP) in breast phyllodes tumor. ( 25337244 )
2014
21
Phyllodes tumor of the breast: role of Axl and ST6GalNAcII in the development of mammary phyllodes tumors. ( 24961352 )
2014
22
Phyllodes Tumor in Survivors of Childhood Osteosarcoma: A Single Institution's Experience. ( 24065044 )
2014
23
Malignant phyllodes tumors display mesenchymal stem cell features and aldehyde dehydrogenase/disialoganglioside identify their tumor stem cells. ( 24670249 )
2014
24
Expression of TWIST1, Snail, Slug, and NF-I_B and methylation of the TWIST1 promoter in mammary phyllodes tumor. ( 23150175 )
2013
25
A subset of malignant phyllodes tumors harbors alterations in the Rb/p16 pathway. ( 23916291 )
2013
26
Ubiquitin carboxy-terminal hydrolase L1 may be involved in the development of mammary phyllodes tumors. ( 23291960 )
2013
27
Phyllodes Tumor of Anogenital Mammary-like Glands with Diffuse Pseudoangiomatous Stromal Hyperplasia. ( 24272935 )
2013
28
The expression of glutamine-metabolism-related proteins in breast phyllodes tumors. ( 23636801 )
2013
29
First case of transformation for breast fibroadenoma to high-grade malignant phyllodes tumor in an in vitro fertilization patient: misdiagnosis of recurrence, treatment and review of the literature. ( 24089229 )
2013
30
Importance of P53, Ki-67 expression in the differential diagnosis of benign/malignant phyllodes tumors of the breast. ( 24056649 )
2013
31
Jejunal intussusception due to malignant phyllodes tumor of the breast. ( 22381472 )
2012
32
Invasive cribriform carcinoma arising in malignant phyllodes tumor of breast: a case report. ( 23110003 )
2012
33
Keratin 15, transcobalamin I and homeobox gene Hox-B13 expression in breast phyllodes tumors: novel markers in biological classification. ( 21574054 )
2012
34
E-cadherin expression in the epithelial components of mammary phyllodes tumors. ( 22820000 )
2012
35
Recurrent Mastitis after Core Needle Biopsy: Case Report of an Unusual Complication after Core Needle Biopsy of a Phyllodes Tumor. ( 22872800 )
2012
36
Severe hypoglycemia with "Big"-IGF-2 oversecretion by a giant phyllode tumor of the breast: a rare case of non-islet cell tumor-induced hypoglycemia (NICTH). ( 22867750 )
2012
37
Phyllodes tumor of the breast: role of CD10 in predicting metastasis. ( 22006372 )
2012
38
Angiosarcoma in recurrent malignant phyllodes tumor of breast. ( 22771666 )
2012
39
Hormone receptors expression in phyllodes tumors of the breast. ( 22590818 )
2012
40
ER, p53 and MIB-1 are significantly associated with malignant phyllodes tumor. ( 23442362 )
2012
41
Ductal carcinoma in situ arising within a benign phyllodes tumor: A case report with a review of the literature. ( 22866068 )
2011
42
Malignant transformation of breast fibroadenoma to malignant phyllodes tumor: long-term outcome of 36 malignant phyllodes tumors. ( 22121516 )
2011
43
Fibroadenoma and phyllodes tumors of anogenital mammary-like glands: a series of 13 neoplasms in 12 cases, including mammary-type juvenile fibroadenoma, fibroadenoma with lactation changes, and neurofibromatosis-associated pseudoangiomatous stromal hyperplasia with multinucleated giant cells. ( 20035149 )
2010
44
c-Kit expression and mutations in phyllodes tumors of the breast. ( 21115932 )
2010
45
Loss of SDHB and NF1 genes in a malignant phyllodes tumor of the breast as detected by oligo-array comparative genomic hybridization. ( 20082856 )
2010
46
A case of a giant phyllodes tumor of the breast with hypoglycemia caused by high-molecular-weight insulin-like growth factor II. ( 19259766 )
2010
47
Borderline and malignant phyllodes tumors display similar promoter methylation profiles. ( 19924440 )
2009
48
Beta-human chorionic gonadotropin production associated with phyllodes tumor of the breast: an unusual paraneoplastic phenomenon. ( 19624411 )
2009
49
Expression of anaphase-promoting complex7 in fibroadenomas and phyllodes tumors of breast. ( 18789487 )
2009
50
Increased epidermal growth factor receptor (EGFR) expression in malignant mammary phyllodes tumors. ( 18443904 )
2009

Variations for Phyllode Tumor

Copy number variations for Phyllode Tumor from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 16441 1 124300000 247249719 Gain Phyllodes tumor
2 38178 10 1 40300000 Loss Phyllodes tumor
3 69804 12 56300000 66000000 Amplification MDM2 Phyllodes tumor
4 77646 13 46200000 48900000 Loss RB1 Phyllodes tumor
5 191456 5 1 180857866 Gain Phyllodes tumor
6 214475 6 60500000 170899992 Loss Phyllodes tumor
7 233913 8 128816946 128822855 Amplification MYC Phyllodes tumor

Expression for Phyllode Tumor

Search GEO for disease gene expression data for Phyllode Tumor.

Pathways for Phyllode Tumor

Pathways related to Phyllode Tumor according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.72 CCNA2 MKI67 TP63 VIM
2 10.98 KIT MME
3 10.88 IGF2 KIT
4 10.67 MKI67 MME VIM

GO Terms for Phyllode Tumor

Biological processes related to Phyllode Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 animal organ regeneration GO:0031100 8.96 CCNA2 MKI67
2 positive regulation of Notch signaling pathway GO:0045747 8.62 KIT TP63

Molecular functions related to Phyllode Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.28 ACPP CCNA2 IGF2 KIT MKI67 MME

Sources for Phyllode Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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