MCID: PHY007
MIFTS: 38

Phyllode Tumor malady

Reproductive diseases, Cancer diseases categories

Summaries for Phyllode Tumor

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Phyllode Tumor, also known as cystosarcoma phylloide, is related to breast malignant phyllodes tumor and breast fibroadenoma. An important gene associated with Phyllode Tumor is NEK8 (NIMA-related kinase 8), and among its related pathways are Cardiac Progenitor Differentiation and Hematopoietic cell lineage. The compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Affiliated tissues include breast, and related mouse phenotypes are muscle and integument.

Aliases & Classifications for Phyllode Tumor

About this section
Sources:
48Orphanet, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Reproductive diseases


Aliases & Descriptions:

phyllode tumor 48
cystosarcoma phylloide 48
cystosarcoma phyllode 48
phyllodes tumor 60
phylloide tumor 48


External Ids:

MESH via Orphanet35 D003557
ICD10 via Orphanet26 D24
UMLS via Orphanet61 C0010701

Related Diseases for Phyllode Tumor

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Phyllode Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1breast malignant phyllodes tumor31.0NEK8
2breast fibroadenoma30.6PGR
3adenocarcinoma30.5VIM, CCNA2, PIP, CGB, MKI67, CD34
4sarcoma30.3VIM, CCNA2, CGB, IGF2, MKI67, CD34
5giant cell tumor30.3ACPP
6prostatitis30.3ACPP
7ductal carcinoma in situ30.0PGR
8cribriform carcinoma30.0PGR, KIT
9spindle cell carcinoma30.0VIM, PGR, ACTC1
10angiosarcoma30.0ACTC1, CD34, VIM
11osteosarcoma30.0CCNA2, CGB, IGF2, ESR2
12adenoma30.0CCNA2, CGB, IGF2, MKI67, ACTC1, ACPP
13benign prostate phyllodes tumor10.5
14benign breast phyllodes tumor10.5
15hypoglycemia10.3
16breast osteosarcoma10.3
17scirrhous adenocarcinoma10.2
18breast adenocarcinoma10.2
19prostate adenocarcinoma10.2
20prostate malignant phyllodes tumor10.2
21neurofibromatosis10.0
22hypoglycemic coma10.0
23inflammatory breast carcinoma10.0
24intussusception10.0
25breast angiosarcoma10.0
26breast metaplastic carcinoma10.0
27in situ carcinoma10.0
28islet cell tumor10.0
29mastitis10.0
30thyroiditis10.0
31uterine carcinosarcoma10.0KIT
32cystadenoma10.0MME
33germ cell tumors10.0KIT
34chordoma10.0VIM
35histiocytosis10.0ACPP
36oligodendroglioma10.0MKI67
37paraganglioma10.0KIT
38lymphangioleiomyomatosis10.0PGR
39gonadoblastoma10.0KIT
40malignant mesothelioma10.0VIM
41kaposi's sarcoma10.0CD34
42chondrosarcoma10.0VIM
43pheochromocytoma10.0CCNA2
44leiomyomatosis10.0PGR
45papilloma10.0ACTC1
46gynecomastia10.0PGR
47lipoma10.0CD34
48progesterone resistance10.0PGR
49breast cyst10.0PIP
50desmoid tumor10.0KIT, ACTC1

Graphical network of the top 20 diseases related to Phyllode Tumor:



Diseases related to phyllode tumor

Clinical Features for Phyllode Tumor

About this section

Drugs & Therapeutics for Phyllode Tumor

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Phyllode Tumor

Drug clinical trials:

Search ClinicalTrials for Phyllode Tumor

Search NIH Clinical Center for Phyllode Tumor

Search CenterWatch for Phyllode Tumor

Genetic Tests for Phyllode Tumor

About this section

Anatomical Context for Phyllode Tumor

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Phyllode Tumor:

32
Breast

Animal Models for Phyllode Tumor or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Phyllode Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.8IGF2, ACTC1, ESR2, CEBPB
2MP:00107719.7CEBPB, IGF2, CD34, HOXB13, MME, ACPP
3MP:00053769.4NEK8, IGF2, CD34, PGR, ACTC1, CEBPB
4MP:00053879.3CCNA2, IGF2, CD34, PGR, MME, KIT
5MP:00053849.2VIM, CCNA2, IGF2, CD34, HOXB13, PGR

Publications for Phyllode Tumor

About this section

Genetic Variations for Phyllode Tumor

About this section

Expression for genes affiliated with Phyllode Tumor

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Phyllode Tumor

Search GEO for disease gene expression data for Phyllode Tumor.

Pathways for genes affiliated with Phyllode Tumor

About this section
Sources:
37NCBI BioSystems Database, 29KEGG, 4Cell Signaling Technology, 51QIAGEN
See all sources

Compounds for genes affiliated with Phyllode Tumor

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB
See all sources

Compounds related to Phyllode Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.8MME
2estrogen4410.8ACPP
3paclitaxel44 49 1112.5CCNA2, IGF2, PGR
42-methoxyethanol4410.5VIM, IGF2, ACTC1
5anastrozole44 1111.4IGF2, MKI67, PGR
6dexamethasone44 49 28 1113.4CEBPB, CCNA2, IGF2, MME
7reticulin4410.4ACTC1, CD34, VIM
8mucicarmine4410.4VIM, PIP, ACTC1
9exemestane49 44 59 1113.4ESR2, PGR, IGF2
104-hydroxytamoxifen4410.3VIM, IGF2, ESR2, PGR
11irinotecan44 49 1112.3KIT, CCNA2, MKI67, IGF2
12methylcellulose4410.3KIT, ACPP, CD34, IGF2
13gefitinib44 49 1112.3ESR2, KIT, IGF2, VIM
14glucose4410.3ACTC1, IGF2, CGB, CEBPB
15vincristine44 49 1112.3CCNA2, KIT, VIM, CGB, MKI67
16mifepristone44 59 28 1113.2CGB, MKI67, PGR, ESR2, CCNA2
17fluorochrome4410.2VIM, CD34, KIT
18progestins4410.2IGF2, MKI67, PGR, ESR2, PIP
19dihydrotestosterone44 28 11 2413.2VIM, ESR2, PIP, PGR, ACPP
20androstenedione44 2411.2PIP, CGB, IGF2, ACPP, ESR2
215fluorouracil4410.2CCNA2, IGF2, MKI67, PGR, KIT
22progestin4410.2IGF2, PGR, ESR2, VIM
23methotrexate44 49 1112.2KIT, CCNA2, VIM, CGB, MKI67, PGR
24ribonucleic acid4410.2MME, KIT, ACTC1, ESR2, PGR, IGF2
25serine4410.2ESR2, ACPP, CCNA2, MKI67
26clomiphene citrate4410.2PGR, ESR2, CGB
27steroid4410.1CCNA2, ACPP, ACTC1, MME, MKI67, PIP
28actinomycin d4410.1VIM, CEBPB, ESR2, KIT, MME, IGF2
29hematoxylin4410.1ACPP, MKI67, CD34, KIT, ACTC1, VIM
30doxorubicin44 49 1112.1KIT, VIM, CCNA2, MKI67, MME, PGR
31agar4410.1IGF2, ACPP, PGR, CD34, VIM
32glycogen44 2411.0VIM, CCNA2, IGF2, MKI67, ACTC1, KIT
33tamoxifen44 49 28 1113.0MKI67, VIM, CCNA2, IGF2, PIP, PGR
34lactate4410.0VIM, ACPP, KIT, MME, MKI67, IGF2
35adenylate4410.0PGR, CEBPB, VIM, IGF2, MME, CCNA2
36fulvestrant44 49 28 1113.0ESR2, PGR, MKI67
37creatinine4410.0ACTC1, ACPP, CGB, IGF2, MME
38thymidine44 2411.0MKI67, ACPP, KIT, MME, IGF2, CD34
39gnrh449.9ACPP, VIM, CGB, IGF2, MKI67, PGR
40etoposide44 49 59 1112.9CGB, ESR2, VIM, CCNA2, IGF2
41arginine449.8IGF2, CCNA2, ESR2, MKI67, ACPP, VIM
4212-o-tetradecanoylphorbol 13-acetate449.8CD34, CCNA2, VIM, CEBPB, MME
43estradiol44 11 2411.6PIP, CGB, IGF2, PGR, ACPP, ESR2
44indomethacin44 59 28 1112.6PGR, MME, CEBPB, VIM, IGF2
45tyrosine449.5CEBPB, CCNA2, IGF2, MKI67, ACPP, KRT15
46vegf449.4VIM, ACPP, ESR2, ACTC1, KIT, MME
47paraffin449.4ESR2, ACPP, ACTC1, KIT, MME, PGR
48retinoic acid44 2410.4KIT, CD34, MKI67, IGF2, CCNA2, VIM
49testosterone44 59 11 2412.3PGR, MKI67, IGF2, CGB, PIP, CCNA2
50progesterone44 59 28 11 2413.1VIM, CCNA2, IGF2, MKI67, CD34, PGR

GO Terms for genes affiliated with Phyllode Tumor

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Phyllode Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epithelial cell maturation involved in prostate gland developmentGO:06074310.2ESR2, HOXB13

Products for genes affiliated with Phyllode Tumor

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Phyllode Tumor

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet