MCID: PHY007
MIFTS: 35

Phyllode Tumor malady

Categories: Reproductive diseases, Rare diseases

Aliases & Classifications for Phyllode Tumor

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Sources:
31ICD10 via Orphanet, 40MESH via Orphanet, 50Novoseek, 54Orphanet, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Phyllode Tumor:

Name: Phyllode Tumor 54
Phyllodes Tumor 50 68
Cystosarcoma Phylloide 54
 
Cystosarcoma Phyllode 54
Phylloide Tumor 54

Characteristics:

Orphanet epidemiological data:

54
cystosarcoma phylloide:
Age of onset: Adult

Classifications:



External Ids:

Orphanet54 ORPHA180261
ICD10 via Orphanet31 D48.6
MESH via Orphanet40 D003557
UMLS via Orphanet69 C0010701

Summaries for Phyllode Tumor

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Wikipedia:71 Phyllodes tumors (from Greek: phullon leaf), also cystosarcoma phyllodes, cystosarcoma phylloides and... more...

MalaCards based summary: Phyllode Tumor, also known as phyllodes tumor, is related to benign breast phyllodes tumor and breast malignant phyllodes tumor. An important gene associated with Phyllode Tumor is VIM (Vimentin), and among its related pathways are B Cell Development Pathways and Cardiac Progenitor Differentiation. Affiliated tissues include breast, prostate and thyroid, and related mouse phenotypes are Increased viability after TNF/CHX stimulation and muscle.

Related Diseases for Phyllode Tumor

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Diseases related to Phyllode Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1benign breast phyllodes tumor33.7PGR, TP63
2breast malignant phyllodes tumor12.1
3benign prostate phyllodes tumor12.0
4prostate malignant phyllodes tumor11.9
5li-fraumeni syndrome11.1
6lymphocytic vasculitis10.6PGR, VIM
7anterograde amnesia10.6PGR, VIM
8mollaret meningitis10.5PGR, VIM
9congenital structural myopathy10.5PGR, VIM
10female reproductive endometrioid cancer10.5PGR, VIM
11familial papillary or follicular thyroid carcinoma10.5MME, VIM
12skin sarcoma10.5MME, VIM
13serous cystadenocarcinoma10.5PGR, VIM
14gangliocytoma10.5MKI67, VIM
15malignant secondary hypertension10.5MME, PGR
16fibrosing mediastinitis10.5PGR, VIM
17uterine body mixed cancer10.5MME, PGR
18chronic end-stage hepatitis c10.5KIT, VIM
19serous surface papilloma10.4MME, PGR
20gallbladder angiosarcoma10.4KIT, PGR
21bartholin's gland adenoid cystic carcinoma10.4KIT, PGR
22tracheal lymphoma10.4MME, PGR
23tooth erosion10.4KIT, VIM
24animal phobia10.4KIT, PGR
25vaginal adenosarcoma10.4KIT, PGR
26clear cell adenocarcinoma10.4MME, VIM
27epithelioid cell melanoma10.4KIT, VIM
28infiltrative basal cell carcinoma10.4KIT, PGR
29cell type benign neoplasm10.4MME, PGR
30cartilage cancer10.4MME, PGR
31cholesteatoma of external ear10.4KIT, PGR
32laryngeal disease10.4KIT, VIM
33small intestinal sarcoma10.4MME, PGR
34papillary thymic adenocarcinoma10.4MME, PGR
35bartholin's gland benign neoplasm10.4TP63, VIM
36pura syndrome10.4KIT, MKI67
37vulvar alveolar soft part sarcoma10.4TP63, VIM
38sarcomatoid renal cell carcinoma10.4KIT, MME
39pancreatic non-invasive mucinous cystadenocarcinoma10.4MME, PGR
40malignant sertoli-leydig cell tumor10.4KIT, MME
41sphenoidal sinus cancer10.4KIT, MME
42ovarian small cell carcinoma10.4KIT, PGR
43localized pulmonary fibrosis10.3KIT, MME
44vascular hemostatic disease10.3TP63, VIM
45gallbladder leiomyosarcoma10.3MME, VIM
46bronchus adenoma10.3KIT, MME
47breast squamous cell carcinoma10.3KIT, PGR
48nerve fibre bundle defect10.3KIT, PGR
49tenosynovitis of foot and ankle10.3KIT, MME
50ocular melanoma10.3KIT, MME

Graphical network of the top 20 diseases related to Phyllode Tumor:



Diseases related to phyllode tumor

Symptoms & Phenotypes for Phyllode Tumor

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GenomeRNAi Phenotypes related to Phyllode Tumor according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00228-A10.3ACPP, KIT

MGI Mouse Phenotypes related to Phyllode Tumor according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.0IGF2, KIT, PGR, TP63, VIM
2MP:00107718.4ACPP, IGF2, KIT, MME, PGR, TP63
3MP:00053808.2CCNA2, IGF2, KIT, PGR, TP63, VIM
4MP:00053877.8CCNA2, IGF2, KIT, MME, PGR, TP63
5MP:00053897.7ACPP, IGF2, KIT, PGR, TP63, VIM

Drugs & Therapeutics for Phyllode Tumor

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Drugs for Phyllode Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
FluorouracilapprovedPhase 1179151-21-83385
Synonyms:
1-fluoro-1h-pyrimidine-2,4-dione
1004-03-1
1upf
2,4-Dihydroxy-5-fluoropyrimidine
2,4-Dioxo-5-fluoropryimidine
2,4-Dioxo-5-fluoropyrimidine
47576_FLUKA
4921-97-5
5 FU Lederle
5 FU medac
5 Fluorouracil
5 Fluorouracil biosyn
5 HU Hexal
5-FU
5-FU (TN)
5-FU Lederle
5-FU medac
5-Faracil
5-Fluor-2,4(1H,3H)-pyrimidindion
5-Fluor-2,4(1H,3H)-pyrimidindion [Czech]
5-Fluor-2,4-dihydroxypyrimidin
5-Fluor-2,4-dihydroxypyrimidin [Czech]
5-Fluor-2,4-pyrimidindiol
5-Fluor-2,4-pyrimidindiol [Czech]
5-Fluoracil
5-Fluoracil [German]
5-Fluoracyl
5-Fluoro-2,4(1H,3H)-pyrimidinedione
5-Fluoro-2,4-pyrimidinedione
5-Fluoropyrimidin-2,4-diol
5-Fluoropyrimidine-2,4-dione
5-Fluorouracil
5-Fluorouracil-biosyn
5-Fluoruracil
5-Fluoruracil [German]
5-Fluracil
5-Ftouracyl
5-HU Hexal
5-fluoro uracil
5-fluoro-1H-pyrimidine-2,4-dione
5-fluoropyrimidine-2,4(1H,3H)-dione
5-fluorouracil
51-21-8
5FU
79108-01-3
AC-11201
AC1L1FTE
AC1Q4N2X
AI3-25297
AKOS000119162
AKOS003237897
AccuSite
Actino-Hermal
Adrucil
Adrucil (TN)
Allergan Brand of Fluorouracil
Arumel
BB_NC-0576
BSPBio_002048
C07649
C4H3FN2O2
CCRIS 2582
CHEBI:46345
CHEMBL185
CID3385
CPD0-1327
CPD000038082
CSP Brand of Fluorouracil
Carac
Carac (TN)
Carzonal
Cinco FU
Cytosafe
D005472
D00584
DB00544
Dakota Brand of Fluorouracil
Dakota, Fluorouracile
Dermatech Brand of Fluorouracil
Dermik Brand of Fluorouracil
DivK1c_000054
EINECS 200-085-6
EU-0100536
Effluderm
Effluderm (free base)
Efudex
Efudix
Efurix
F 6627
F0151
F6627_SIGMA
F8423_SIGMA
FT-0082524
FU
Ferrer Brand of Fluorouracil
Fiverocil
Fluoro Uracil
Fluoro Uracile ICN
Fluoro-Uracile ICN
Fluoro-uracile
Fluoro-uracilo
Fluoroblastin
Fluoroplex
Fluoroplex (TN)
Fluorouracil
Fluorouracil (JP15/USP/INN)
Fluorouracil GRY
Fluorouracil Mononitrate
Fluorouracil Monopotassium Salt
Fluorouracil Monosodium Salt
Fluorouracil Potassium Salt
Fluorouracil Teva Brand
Fluorouracil [USAN:INN:BAN:JAN]
 
Fluorouracil-GRY
Fluorouracile
Fluorouracile Dakota
Fluorouracile [DCIT]
Fluorouracilo
Fluorouracilo Ferrer Far
Fluorouracilo [INN-Spanish]
Fluorouracilum
Fluorouracilum [INN-Latin]
Fluoruracil
Fluouracil
Flurablastin
Fluracedyl
Fluracil
Fluracilum
Fluri
Fluril
Fluro Uracil
Fluroblastin
Flurodex
Flurouracil
Flurox
Ftoruracil
Gry Brand of Fluorouracil
HMS1920O18
HMS2090I04
HMS2091F19
HMS500C16
HSDB 3228
Haemato Brand of Fluorouracil
Haemato fu
Haemato-fu
Hexal Brand of Fluorouracil
I07-0022
ICN Brand of Fluorouracil
IDI1_000054
IN1335
KBio1_000054
KBio2_001321
KBio2_003889
KBio2_006457
KBio3_001268
KBioGR_001253
KBioSS_001321
Kecimeton
LS-153
Lopac-F-6627
Lopac0_000536
MLS000069498
MLS002415705
MolPort-000-156-102
MolPort-003-990-447
MolPort-004-758-143
MolPort-004-758-144
MolPort-005-861-486
NCGC00015442-01
NCGC00015442-03
NCGC00015442-10
NCGC00091349-01
NCGC00091349-02
NCGC00091349-03
NCGC00091349-04
NCGC00091349-05
NCGC00091349-07
NCGC00091349-08
NCI60_001652
NINDS_000054
NSC 19893
NSC-19893
NSC19893
Neocorp Brand of Fluorouracil
Neofluor
Onkofluor
Onkoworks Brand of Fluorouracil
Phthoruracil
Phtoruracil
Queroplex
Ribofluor
Riemser Brand of Fluorouracil
Ro 2-9757
Ro-2-9757
Roche Brand of Fluorouracil
S1209_Selleck
SAM002264615
SMR000038082
SPBio_000291
SPECTRUM1500305
STK297802
Spectrum2_000076
Spectrum3_000434
Spectrum4_000557
Spectrum5_000718
Spectrum_000841
T5233394
TL8006093
Teva Brand of Fluorouracil
Timazin
U 8953
U-8953
UNII-U3P01618RT
UPCMLD-DP130
UPCMLD-DP130:001
URF
Ulup
WLN: T6MVMVJ EF
ZINC00897110
biosyn Brand of Fluorouracil
fluorouracil
inhibits thymilidate synthetase
medac Brand of Fluorouracil
nchembio.90-comp3
nchembio809-comp6
ribosepharm Brand of Fluorouracil
tetratogen
2
Belinostatapproved, investigationalPhase 142866323-14-0
Synonyms:
 
Belinostat
PXD 101
3Immunosuppressive AgentsPhase 112770
4Histone Deacetylase InhibitorsPhase 1566
5AntimetabolitesPhase 111774
6AndrogensPhase 11275
7Antimetabolites, AntineoplasticPhase 17171

Interventional clinical trials:

idNameStatusNCT IDPhase
1Radiation Therapy After Surgery in Treating Women With Phyllodes Tumor of the BreastActive, not recruitingNCT00003404Phase 2
2Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid TumorsCompletedNCT00413322Phase 1
3Phyllodes Tumor Partial Breast Radiation StudyRecruitingNCT01089374
4Establishing Technique for PECS2 Catheter InsertionActive, not recruitingNCT03030677

Search NIH Clinical Center for Phyllode Tumor

Genetic Tests for Phyllode Tumor

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Anatomical Context for Phyllode Tumor

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MalaCards organs/tissues related to Phyllode Tumor:

36
Breast, Prostate, Thyroid, Lung

Publications for Phyllode Tumor

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Articles related to Phyllode Tumor:

(show top 50)    (show all 78)
idTitleAuthorsYear
1
A Case of Giant Borderline Phyllodes Tumor of the Breast Associated with Hypoglycemia. (27628602)
2016
2
IMP3 Is Strongly Expressed in Malignant Phyllodes Tumors of the Breast: An Immunohistochemical Study. (26353850)
2016
3
Loss of imprinting of IGF2 in fibroadenomas and phyllodes tumors of the breast. (26676988)
2016
4
Mutational analysis of MED12 in fibroadenomas and phyllodes tumors of the breast by means of targeted next-generation sequencing. (26093648)
2015
5
Recurrent angio-fibroma of breast masquerading as phyllodes tumor. (26458623)
2015
6
CD117 expression in breast phyllodes tumors correlates with adverse pathologic parameters and reduced survival. (25216225)
2015
7
Next-Gen Sequencing Exposes Frequent MED12 Mutations and Actionable Therapeutic Targets in Phyllodes Tumors. (25593300)
2015
8
MED12 exon 2 mutations in phyllodes tumors of the breast. (25865354)
2015
9
Pleomorphic liposarcoma arising in a malignant phyllodes tumor of breast: A rare occurrence. (26881623)
2015
10
TERT promoter mutations are frequent and show association with MED12 mutations in phyllodes tumors of the breast. (26355235)
2015
11
C-kit overexpression correlates with KIT gene copy numbers increases in phyllodes tumors of the breast. (25534827)
2015
12
Distribution of MED12 mutations in fibroadenomas and phyllodes tumors of the breast--implications for tumor biology and pathological diagnosis. (25931199)
2015
13
Liposarcoma of the breast arising in a malignant phyllodes tumor: A case report and review of the literature. (26468454)
2015
14
Nuclear survivin expression in stromal cells of phyllodes tumors and fibroadenomas of the breast. (24596368)
2014
15
Expression of Yes-associated protein (YAP) in breast phyllodes tumor. (25337244)
2014
16
Malignant phyllodes tumors display mesenchymal stem cell features and aldehyde dehydrogenase/disialoganglioside identify their tumor stem cells. (24670249)
2014
17
Collision tumor with inflammatory breast carcinoma and malignant phyllodes tumor: a case report and literature review. (24400686)
2014
18
Phyllodes tumor of the breast: role of Axl and ST6GalNAcII in the development of mammary phyllodes tumors. (24961352)
2014
19
miR-21 induces myofibroblast differentiation and promotes the malignant progression of breast phyllodes tumors. (24980553)
2014
20
Phyllodes Tumor in Survivors of Childhood Osteosarcoma: A Single Institution's Experience. (24065044)
2014
21
The expression of glutamine-metabolism-related proteins in breast phyllodes tumors. (23636801)
2013
22
Ubiquitin carboxy-terminal hydrolase L1 may be involved in the development of mammary phyllodes tumors. (23291960)
2013
23
Importance of P53, Ki-67 expression in the differential diagnosis of benign/malignant phyllodes tumors of the breast. (24056649)
2013
24
First case of transformation for breast fibroadenoma to high-grade malignant phyllodes tumor in an in vitro fertilization patient: misdiagnosis of recurrence, treatment and review of the literature. (24089229)
2013
25
Expression of TWIST1, Snail, Slug, and NF-I_B and methylation of the TWIST1 promoter in mammary phyllodes tumor. (23150175)
2013
26
A subset of malignant phyllodes tumors harbors alterations in the Rb/p16 pathway. (23916291)
2013
27
Phyllodes Tumor of Anogenital Mammary-like Glands with Diffuse Pseudoangiomatous Stromal Hyperplasia. (24272935)
2013
28
Phyllodes tumor of the breast: role of CD10 in predicting metastasis. (22006372)
2012
29
Angiosarcoma in recurrent malignant phyllodes tumor of breast. (22771666)
2012
30
Severe hypoglycemia with "Big"-IGF-2 oversecretion by a giant phyllode tumor of the breast: a rare case of non-islet cell tumor-induced hypoglycemia (NICTH). (22867750)
2012
31
ER, p53 and MIB-1 are significantly associated with malignant phyllodes tumor. (23442362)
2012
32
Invasive cribriform carcinoma arising in malignant phyllodes tumor of breast: a case report. (23110003)
2012
33
Hormone receptors expression in phyllodes tumors of the breast. (22590818)
2012
34
Jejunal intussusception due to malignant phyllodes tumor of the breast. (22381472)
2012
35
E-cadherin expression in the epithelial components of mammary phyllodes tumors. (22820000)
2012
36
Keratin 15, transcobalamin I and homeobox gene Hox-B13 expression in breast phyllodes tumors: novel markers in biological classification. (21574054)
2012
37
Recurrent Mastitis after Core Needle Biopsy: Case Report of an Unusual Complication after Core Needle Biopsy of a Phyllodes Tumor. (22872800)
2012
38
Ductal carcinoma in situ arising within a benign phyllodes tumor: A case report with a review of the literature. (22866068)
2011
39
Malignant transformation of breast fibroadenoma to malignant phyllodes tumor: long-term outcome of 36 malignant phyllodes tumors. (22121516)
2011
40
A case of a giant phyllodes tumor of the breast with hypoglycemia caused by high-molecular-weight insulin-like growth factor II. (19259766)
2010
41
Fibroadenoma and phyllodes tumors of anogenital mammary-like glands: a series of 13 neoplasms in 12 cases, including mammary-type juvenile fibroadenoma, fibroadenoma with lactation changes, and neurofibromatosis-associated pseudoangiomatous stromal hyperplasia with multinucleated giant cells. (20035149)
2010
42
c-Kit expression and mutations in phyllodes tumors of the breast. (21115932)
2010
43
Loss of SDHB and NF1 genes in a malignant phyllodes tumor of the breast as detected by oligo-array comparative genomic hybridization. (20082856)
2010
44
Expression of anaphase-promoting complex7 in fibroadenomas and phyllodes tumors of breast. (18789487)
2009
45
An approach to malignant mammary phyllodes tumors detection. (19441158)
2009
46
Borderline and malignant phyllodes tumors display similar promoter methylation profiles. (19924440)
2009
47
Molecular pathogenesis of progression and recurrence in breast phyllodes tumors. (19966935)
2009
48
Beta-human chorionic gonadotropin production associated with phyllodes tumor of the breast: an unusual paraneoplastic phenomenon. (19624411)
2009
49
Increased epidermal growth factor receptor (EGFR) expression in malignant mammary phyllodes tumors. (18443904)
2009
50
Benign phyllodes tumor of the breast with intracytoplasmic inclusion bodies identical to infantile digital fibromatosis. (18266786)
2008

Variations for Phyllode Tumor

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Copy number variations for Phyllode Tumor from CNVD:

6
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1164411124300000247249719GainPhyllodes tumor
23817810140300000LossPhyllodes tumor
369804125630000066000000AmplificationMDM2Phyllodes tumor
477646134620000048900000LossRB1Phyllodes tumor
519145651180857866GainPhyllodes tumor
6214475660500000170899992LossPhyllodes tumor
72339138128816946128822855AmplificationMYCPhyllodes tumor

Expression for genes affiliated with Phyllode Tumor

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Search GEO for disease gene expression data for Phyllode Tumor.

Pathways for genes affiliated with Phyllode Tumor

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Pathways related to Phyllode Tumor according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.6KIT, MME
29.4IGF2, KIT
38.4CCNA2, MKI67, TP63, VIM

GO Terms for genes affiliated with Phyllode Tumor

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Biological processes related to Phyllode Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of Notch signaling pathwayGO:00457479.9KIT, TP63
2response to radiationGO:00093149.4IGF2, KIT

Sources for Phyllode Tumor

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet