MCID: PHY007
MIFTS: 22

Phyllode Tumor malady

Categories: Reproductive diseases, Rare diseases

Aliases & Classifications for Phyllode Tumor

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Sources:
52Orphanet, 48Novoseek, 66UMLS, 38MESH via Orphanet, 29ICD10 via Orphanet, 67UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Phyllode Tumor:

Name: Phyllode Tumor 52
Phyllodes Tumor 48 66
Cystosarcoma Phylloide 52
 
Cystosarcoma Phyllode 52
Phylloide Tumor 52

Characteristics:

Orphanet epidemiological data:

52
cystosarcoma phylloide:
Age of onset: Adult

Classifications:



External Ids:

Orphanet52 ORPHA180261
MESH via Orphanet38 D003557
ICD10 via Orphanet29 D48.6
UMLS via Orphanet67 C0010701

Summaries for Phyllode Tumor

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Wikipedia:69 Phyllodes tumors (from Greek: phullon leaf), also cystosarcoma phyllodes, cystosarcoma phylloides and... more...

MalaCards based summary: Phyllode Tumor, also known as phyllodes tumor, is related to breast malignant phyllodes tumor and benign breast phyllodes tumor. Affiliated tissues include breast, prostate and thyroid.

Related Diseases for Phyllode Tumor

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Graphical network of the top 20 diseases related to Phyllode Tumor:



Diseases related to phyllode tumor

Symptoms for Phyllode Tumor

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Drugs & Therapeutics for Phyllode Tumor

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Drugs for Phyllode Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
FluorouracilPhase 1172851-21-83385
Synonyms:
1-fluoro-1h-pyrimidine-2,4-dione
1004-03-1
1upf
2,4-Dihydroxy-5-fluoropyrimidine
2,4-Dioxo-5-fluoropryimidine
2,4-Dioxo-5-fluoropyrimidine
47576_FLUKA
4921-97-5
5 FU Lederle
5 FU medac
5 Fluorouracil
5 Fluorouracil biosyn
5 HU Hexal
5-FU
5-FU (TN)
5-FU Lederle
5-FU medac
5-Faracil
5-Fluor-2,4(1H,3H)-pyrimidindion
5-Fluor-2,4(1H,3H)-pyrimidindion [Czech]
5-Fluor-2,4-dihydroxypyrimidin
5-Fluor-2,4-dihydroxypyrimidin [Czech]
5-Fluor-2,4-pyrimidindiol
5-Fluor-2,4-pyrimidindiol [Czech]
5-Fluoracil
5-Fluoracil [German]
5-Fluoracyl
5-Fluoro-2,4(1H,3H)-pyrimidinedione
5-Fluoro-2,4-pyrimidinedione
5-Fluoropyrimidin-2,4-diol
5-Fluoropyrimidine-2,4-dione
5-Fluorouracil
5-Fluorouracil-biosyn
5-Fluoruracil
5-Fluoruracil [German]
5-Fluracil
5-Ftouracyl
5-HU Hexal
5-fluoro uracil
5-fluoro-1H-pyrimidine-2,4-dione
5-fluoropyrimidine-2,4(1H,3H)-dione
5-fluorouracil
51-21-8
5FU
79108-01-3
AC-11201
AC1L1FTE
AC1Q4N2X
AI3-25297
AKOS000119162
AKOS003237897
AccuSite
Actino-Hermal
Adrucil
Adrucil (TN)
Allergan Brand of Fluorouracil
Arumel
BB_NC-0576
BSPBio_002048
C07649
C4H3FN2O2
CCRIS 2582
CHEBI:46345
CHEMBL185
CID3385
CPD0-1327
CPD000038082
CSP Brand of Fluorouracil
Carac
Carac (TN)
Carzonal
Cinco FU
Cytosafe
D005472
D00584
DB00544
Dakota Brand of Fluorouracil
Dakota, Fluorouracile
Dermatech Brand of Fluorouracil
Dermik Brand of Fluorouracil
DivK1c_000054
EINECS 200-085-6
EU-0100536
Effluderm
Effluderm (free base)
Efudex
Efudix
Efurix
F 6627
F0151
F6627_SIGMA
F8423_SIGMA
FT-0082524
FU
Ferrer Brand of Fluorouracil
Fiverocil
Fluoro Uracil
Fluoro Uracile ICN
Fluoro-Uracile ICN
Fluoro-uracile
Fluoro-uracilo
Fluoroblastin
Fluoroplex
Fluoroplex (TN)
Fluorouracil
Fluorouracil (JP15/USP/INN)
Fluorouracil GRY
Fluorouracil Mononitrate
Fluorouracil Monopotassium Salt
Fluorouracil Monosodium Salt
Fluorouracil Potassium Salt
Fluorouracil Teva Brand
Fluorouracil [USAN:INN:BAN:JAN]
 
Fluorouracil-GRY
Fluorouracile
Fluorouracile Dakota
Fluorouracile [DCIT]
Fluorouracilo
Fluorouracilo Ferrer Far
Fluorouracilo [INN-Spanish]
Fluorouracilum
Fluorouracilum [INN-Latin]
Fluoruracil
Fluouracil
Flurablastin
Fluracedyl
Fluracil
Fluracilum
Fluri
Fluril
Fluro Uracil
Fluroblastin
Flurodex
Flurouracil
Flurox
Ftoruracil
Gry Brand of Fluorouracil
HMS1920O18
HMS2090I04
HMS2091F19
HMS500C16
HSDB 3228
Haemato Brand of Fluorouracil
Haemato fu
Haemato-fu
Hexal Brand of Fluorouracil
I07-0022
ICN Brand of Fluorouracil
IDI1_000054
IN1335
KBio1_000054
KBio2_001321
KBio2_003889
KBio2_006457
KBio3_001268
KBioGR_001253
KBioSS_001321
Kecimeton
LS-153
Lopac-F-6627
Lopac0_000536
MLS000069498
MLS002415705
MolPort-000-156-102
MolPort-003-990-447
MolPort-004-758-143
MolPort-004-758-144
MolPort-005-861-486
NCGC00015442-01
NCGC00015442-03
NCGC00015442-10
NCGC00091349-01
NCGC00091349-02
NCGC00091349-03
NCGC00091349-04
NCGC00091349-05
NCGC00091349-07
NCGC00091349-08
NCI60_001652
NINDS_000054
NSC 19893
NSC-19893
NSC19893
Neocorp Brand of Fluorouracil
Neofluor
Onkofluor
Onkoworks Brand of Fluorouracil
Phthoruracil
Phtoruracil
Queroplex
Ribofluor
Riemser Brand of Fluorouracil
Ro 2-9757
Ro-2-9757
Roche Brand of Fluorouracil
S1209_Selleck
SAM002264615
SMR000038082
SPBio_000291
SPECTRUM1500305
STK297802
Spectrum2_000076
Spectrum3_000434
Spectrum4_000557
Spectrum5_000718
Spectrum_000841
T5233394
TL8006093
Teva Brand of Fluorouracil
Timazin
U 8953
U-8953
UNII-U3P01618RT
UPCMLD-DP130
UPCMLD-DP130:001
URF
Ulup
WLN: T6MVMVJ EF
ZINC00897110
biosyn Brand of Fluorouracil
fluorouracil
inhibits thymilidate synthetase
medac Brand of Fluorouracil
nchembio.90-comp3
nchembio809-comp6
ribosepharm Brand of Fluorouracil
tetratogen
2
BelinostatPhase 142
Synonyms:
 
Belinostat
PXD 101

Interventional clinical trials:

idNameStatusNCT IDPhase
1Radiation Therapy After Surgery in Treating Women With Phyllodes Tumor of the BreastActive, not recruitingNCT00003404Phase 2
2Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid TumorsCompletedNCT00413322Phase 1
3Phyllodes Tumor Partial Breast Radiation StudyRecruitingNCT01089374

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Genetic Tests for Phyllode Tumor

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Anatomical Context for Phyllode Tumor

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MalaCards organs/tissues related to Phyllode Tumor:

34
Breast, Prostate, Thyroid, Lung

Animal Models for Phyllode Tumor or affiliated genes

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Publications for Phyllode Tumor

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Articles related to Phyllode Tumor:

(show top 50)    (show all 76)
idTitleAuthorsYear
1
A Case of Giant Borderline Phyllodes Tumor of the Breast Associated with Hypoglycemia. (27628602)
2016
2
Mutational analysis of MED12 in fibroadenomas and phyllodes tumors of the breast by means of targeted next-generation sequencing. (26093648)
2015
3
Recurrent angio-fibroma of breast masquerading as phyllodes tumor. (26458623)
2015
4
CD117 expression in breast phyllodes tumors correlates with adverse pathologic parameters and reduced survival. (25216225)
2015
5
Next-Gen Sequencing Exposes Frequent MED12 Mutations and Actionable Therapeutic Targets in Phyllodes Tumors. (25593300)
2015
6
MED12 exon 2 mutations in phyllodes tumors of the breast. (25865354)
2015
7
Pleomorphic liposarcoma arising in a malignant phyllodes tumor of breast: A rare occurrence. (26881623)
2015
8
TERT promoter mutations are frequent and show association with MED12 mutations in phyllodes tumors of the breast. (26355235)
2015
9
Nuclear survivin expression in stromal cells of phyllodes tumors and fibroadenomas of the breast. (24596368)
2014
10
Expression of Yes-associated protein (YAP) in breast phyllodes tumor. (25337244)
2014
11
Malignant phyllodes tumors display mesenchymal stem cell features and aldehyde dehydrogenase/disialoganglioside identify their tumor stem cells. (24670249)
2014
12
Collision tumor with inflammatory breast carcinoma and malignant phyllodes tumor: a case report and literature review. (24400686)
2014
13
The expression of glutamine-metabolism-related proteins in breast phyllodes tumors. (23636801)
2013
14
Ubiquitin carboxy-terminal hydrolase L1 may be involved in the development of mammary phyllodes tumors. (23291960)
2013
15
Importance of P53, Ki-67 expression in the differential diagnosis of benign/malignant phyllodes tumors of the breast. (24056649)
2013
16
First case of transformation for breast fibroadenoma to high-grade malignant phyllodes tumor in an in vitro fertilization patient: misdiagnosis of recurrence, treatment and review of the literature. (24089229)
2013
17
Expression of TWIST1, Snail, Slug, and NF-I_B and methylation of the TWIST1 promoter in mammary phyllodes tumor. (23150175)
2013
18
Phyllodes tumor of the breast: role of CD10 in predicting metastasis. (22006372)
2012
19
Angiosarcoma in recurrent malignant phyllodes tumor of breast. (22771666)
2012
20
Severe hypoglycemia with "Big"-IGF-2 oversecretion by a giant phyllode tumor of the breast: a rare case of non-islet cell tumor-induced hypoglycemia (NICTH). (22867750)
2012
21
ER, p53 and MIB-1 are significantly associated with malignant phyllodes tumor. (23442362)
2012
22
Ductal carcinoma in situ arising within a benign phyllodes tumor: A case report with a review of the literature. (22866068)
2011
23
A case of a giant phyllodes tumor of the breast with hypoglycemia caused by high-molecular-weight insulin-like growth factor II. (19259766)
2010
24
Fibroadenoma and phyllodes tumors of anogenital mammary-like glands: a series of 13 neoplasms in 12 cases, including mammary-type juvenile fibroadenoma, fibroadenoma with lactation changes, and neurofibromatosis-associated pseudoangiomatous stromal hyperplasia with multinucleated giant cells. (20035149)
2010
25
c-Kit expression and mutations in phyllodes tumors of the breast. (21115932)
2010
26
Expression of anaphase-promoting complex7 in fibroadenomas and phyllodes tumors of breast. (18789487)
2009
27
An approach to malignant mammary phyllodes tumors detection. (19441158)
2009
28
Borderline and malignant phyllodes tumors display similar promoter methylation profiles. (19924440)
2009
29
Molecular pathogenesis of progression and recurrence in breast phyllodes tumors. (19966935)
2009
30
Benign phyllodes tumor of the breast with intracytoplasmic inclusion bodies identical to infantile digital fibromatosis. (18266786)
2008
31
Association of the BRCA1 missense variant R1699W with a malignant phyllodes tumor of the breast. (17574969)
2007
32
Amplifications of EGFR gene and protein expression of EGFR, Her-2/neu, c-kit, and androgen receptor in phyllodes tumor of the prostate. (17192792)
2007
33
Phyllodes tumor: a clinicopathologic and immunohistochemical study of 30 cases. (17090194)
2006
34
CD10, actin, and vimentin expression in breast phyllodes tumors correlates with tumor grades of the WHO grading system. (16703173)
2006
35
Estrogen receptor-beta is expressed in stromal cells of fibroadenoma and phyllodes tumors of the breast. (16554735)
2006
36
Amplifications of the epidermal growth factor receptor gene (egfr) are common in phyllodes tumors of the breast and are associated with tumor progression. (16258523)
2006
37
Malignant phyllode tumor metastatic to the duodenum. (16570365)
2006
38
p53 and c-kit (CD117) protein expression as prognostic indicators in breast phyllodes tumors: a tissue microarray study. (16258510)
2005
39
Expression of p53 protein and Ki-67 antigen in phyllodes tumor of the breast. (15077883)
2004
40
Increased c-kit (CD117) expression in malignant mammary phyllodes tumors. (15044924)
2004
41
Characterization of lesions of the breast with proton MR spectroscopy: comparison of carcinomas, benign lesions, and phyllodes tumors. (14573418)
2003
42
Hormonal receptors expression in epithelial cells of mammary phyllodes tumors correlates with pathologic grade of the tumor: a multicenter study of 143 cases. (12375638)
2002
43
Proliferating activity in differential diagnosis of benign phyllodes tumor and cellular fibroadenomas: is it helpful? (11692149)
2001
44
Prognostic evaluation of proliferative activity and DNA content in the phyllodes tumor of the breast: immunohistochemical and flow cytometric study of 118 cases. (11245343)
2001
45
Malignant phyllodes tumor of the breast with expression of osteonectin and vinculin. (11350610)
2001
46
CD34, CD117, and actin expression in phyllodes tumor of the breast. (11104647)
2000
47
Platelet-derived growth factor expression in phyllodes tumors and fibroadenomas of the breast. (11070114)
2000
48
Malignant phyllodes tumor of breast with lung metastases mimicking the primary. (9777991)
1998
49
Progression of fibroadenoma to phyllodes tumor demonstrated by clonal analysis. (8625047)
1995
50
Phyllodes tumor of the breast containing the intracytoplasmic inclusion bodies identical with infantile digital fibromatosis. (8172324)
1994

Variations for Phyllode Tumor

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Copy number variations for Phyllode Tumor from CNVD:

6
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1164411124300000247249719GainPhyllodes tumor
23817810140300000LossPhyllodes tumor
369804125630000066000000AmplificationMDM2Phyllodes tumor
477646134620000048900000LossRB1Phyllodes tumor
519145651180857866GainPhyllodes tumor
6214475660500000170899992LossPhyllodes tumor
72339138128816946128822855AmplificationMYCPhyllodes tumor

Expression for genes affiliated with Phyllode Tumor

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Search GEO for disease gene expression data for Phyllode Tumor.

Pathways for genes affiliated with Phyllode Tumor

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GO Terms for genes affiliated with Phyllode Tumor

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Sources for Phyllode Tumor

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet