Aliases & Classifications for Physical Disorder

MalaCards integrated aliases for Physical Disorder:

Name: Physical Disorder 12 14
Physical Illness 69

External Ids:

Disease Ontology 12 DOID:0080015
UMLS 69 C0683323

Summaries for Physical Disorder

Disease Ontology : 12 A disease that has material basis in a genetic abnormality, error with embryonic development, infection or compromised intrauterine environment.

MalaCards based summary : Physical Disorder, also known as physical illness, is related to agnathia-otocephaly complex and acquired schizencephaly, and has symptoms including illness (finding) An important gene associated with Physical Disorder is RNU4ATAC (RNA, U4atac Small Nuclear (U12-Dependent Splicing)), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Tgif disruption of Shh signaling. The drugs Chlorpromazine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and breast, and related phenotypes are cellular and cardiovascular system

Wikipedia : 72 A physical disorder (as a medical term) is often used as a term in contrast to a mental disorder, in an... more...

Related Diseases for Physical Disorder

Diseases related to Physical Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 agnathia-otocephaly complex 31.4 MSX1 NODAL SHH
2 acquired schizencephaly 10.6 SHH SIX3
3 cleft lip and alveolus 10.6 IRF6 MSX1
4 maxillonasal dysplasia, binder type 10.6 SATB2 SHH
5 patau syndrome 10.5 NODAL SIX3 ZIC2
6 anus, imperforate 10.5 GLI3 SATB2 SHH
7 holoprosencephaly 4 10.5 GLI3 SHH ZIC2
8 septopreoptic holoprosencephaly 10.5 NODAL SHH SIX3 ZIC2
9 tooth size 10.5 MSX1 SHH
10 midline interhemispheric variant of holoprosencephaly 10.5 NODAL SHH SIX3 ZIC2
11 microform holoprosencephaly 10.5 NODAL SHH SIX3 ZIC2
12 alobar holoprosencephaly 10.5 NODAL SHH SIX3 ZIC2
13 lobar holoprosencephaly 10.5 NODAL SHH SIX3 ZIC2
14 chromosome 18p deletion syndrome 10.5 NODAL SHH SIX3 ZIC2
15 hard palate cancer 10.5 MSX1 SHOX2 TMEM54
16 schizencephaly 10.5 SHH SIX3 WDR62
17 semilobar holoprosencephaly 10.5 NODAL SHH SIX3 ZIC2
18 bone development disease 10.5 GLI3 PIK3R2 RNU4ATAC SHOX2
19 chromosome 2q35 duplication syndrome 10.5 GLI3 PIK3R2 SATB2
20 visceral heterotaxy 10.5
21 fetal alcohol spectrum disorder 10.5
22 renal-hepatic-pancreatic dysplasia 10.5
23 omphalocele 10.5
24 bladder exstrophy-epispadias-cloacal exstrophy complex 10.5
25 klippel-feil syndrome 10.5
26 hypospadias 10.5
27 patulous eustachian tube 10.5
28 popliteal pterygium syndrome 10.5 IRF6 NHLH1 SATB2
29 talipes equinovarus 10.4 GLI3 IRF6
30 isolated cleft lip 10.4 IRF6 MSX1
31 seckel syndrome 10.4 CEP63 MCPH1 RNU4ATAC
32 holoprosencephaly 10.4 GLI3 NODAL SHH SIX3 ZIC2
33 cleft palate, isolated 10.3 IRF6 MSX1 NHLH1 SATB2 TMEM54
34 tooth agenesis 10.3 GLI3 IRF6 MSX1 SATB2 TMEM54
35 cleft lip 10.2 IRF6 MSX1 SATB2
36 choanal atresia, posterior 10.2 SATB2 SHH
37 orofacial cleft 10.0 IRF6 MSX1 NHLH1 NODAL RPS17 SATB2
38 congenital nervous system abnormality 10.0 CEP63 MCPH1 NODAL PAFAH1B1 RNU4ATAC SHH
39 aging 9.7
40 paine syndrome 9.4
41 episodic pain syndrome, familial, 1 9.4
42 alacrima, achalasia, and mental retardation syndrome 9.4
43 global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies 9.4
44 alexithymia 9.4
45 disease of mental health 9.4
46 genital herpes 9.4
47 ring chromosome y syndrome 9.4

Graphical network of the top 20 diseases related to Physical Disorder:



Diseases related to Physical Disorder

Symptoms & Phenotypes for Physical Disorder

UMLS symptoms related to Physical Disorder:


illness (finding)

MGI Mouse Phenotypes related to Physical Disorder:

43 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.29 CEP63 GLI3 INSL3 IRF6 MCPH1 NODAL
2 cardiovascular system MP:0005385 10.26 GLI3 MCPH1 MSX1 NHLH1 NODAL PIK3R2
3 growth/size/body region MP:0005378 10.25 PAFAH1B1 PIK3R2 SATB2 SHH SHOX2 SIX3
4 craniofacial MP:0005382 10.15 GLI3 IRF6 MSX1 NODAL SATB2 SHH
5 digestive/alimentary MP:0005381 10.13 GLI3 IRF6 MSX1 NODAL SATB2 SHH
6 mortality/aging MP:0010768 10.13 GLI3 IRF6 MCPH1 MSX1 PAFAH1B1 SATB2
7 embryo MP:0005380 10.11 SATB2 SHH SIX3 ZIC2 GLI3 IRF6
8 nervous system MP:0003631 10.1 CEP63 GLI3 MCPH1 MSX1 NHLH1 NODAL
9 endocrine/exocrine gland MP:0005379 10.09 CEP63 GLI3 INSL3 MCPH1 MSX1 PAFAH1B1
10 limbs/digits/tail MP:0005371 9.91 GLI3 IRF6 MSX1 SATB2 SHH SHOX2
11 respiratory system MP:0005388 9.76 GLI3 MSX1 NODAL SATB2 SHH SIX3
12 skeleton MP:0005390 9.7 GLI3 INSL3 IRF6 MCPH1 MSX1 NODAL
13 taste/olfaction MP:0005394 8.92 GLI3 NODAL SHH SIX3

Drugs & Therapeutics for Physical Disorder

Drugs for Physical Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chlorpromazine Approved, Investigational, Vet_approved Phase 4 50-53-3 2726
2
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
3
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
4
Bupropion Approved Phase 4 34911-55-2, 34841-39-9 444
5 Antidepressive Agents Phase 4,Phase 2
6 Antiemetics Phase 4
7 Antimanic Agents Phase 4
8 Antipsychotic Agents Phase 4
9 Autonomic Agents Phase 4,Phase 2
10 Central Nervous System Depressants Phase 4,Phase 3,Phase 1
11 Dopamine Agents Phase 4
12 Dopamine Antagonists Phase 4
13 Gastrointestinal Agents Phase 4
14 Lithium carbonate Phase 4 554-13-2
15 Neurotransmitter Agents Phase 4,Phase 2
16 Neurotransmitter Uptake Inhibitors Phase 4,Phase 2
17 Peripheral Nervous System Agents Phase 4,Phase 2
18 Psychotropic Drugs Phase 4,Phase 2
19
Serotonin Phase 4,Phase 2 50-67-9 5202
20 Serotonin Agents Phase 4,Phase 2
21 Serotonin Uptake Inhibitors Phase 4,Phase 2
22 Tranquilizing Agents Phase 4
23 Antidepressive Agents, Second-Generation Phase 4,Phase 2
24 Cytochrome P-450 CYP2D6 Inhibitors Phase 4
25 Cytochrome P-450 Enzyme Inhibitors Phase 4
26 Dopamine agonists Phase 4
27 Dopamine Uptake Inhibitors Phase 4
28
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
29
Eszopiclone Approved, Investigational Phase 3,Phase 1 138729-47-2 969472
30 tannic acid Approved, Nutraceutical Phase 3
31 Hypnotics and Sedatives Phase 3,Phase 1
32
Citalopram Approved Phase 2 59729-33-8 2771
33
Moclobemide Approved, Investigational Phase 2 71320-77-9 4235
34 Antiparkinson Agents Phase 2
35 Cholinergic Agents Phase 2
36 Cholinergic Antagonists Phase 2
37 Monoamine Oxidase Inhibitors Phase 2
38 Muscarinic Antagonists Phase 2
39 Parasympatholytics Phase 2
40
Menthol Approved 2216-51-5 16666
41
Sulpiride Approved, Investigational 15676-16-1 5355
42 interferons
43 Cariostatic Agents
44 Dihydroxyphenylalanine
45 Fluorides
46 Protective Agents
47 sultopride
48 Hypoglycemic Agents
49 insulin
50 Insulin, Globin Zinc

Interventional clinical trials:

(show all 41)

# Name Status NCT ID Phase Drugs
1 Comparison of Combination Olanzapine+Lithium or Chlorpromazine+Lithium in Treatment of First Manic Episode With Psychotic Features Unknown status NCT00202293 Phase 4 Olanzapine;Lithium;Chlorpromazine
2 Treating Disrupted Sleep in Individuals With Inflammatory Bowel Disease Completed NCT02162862 Phase 4 bupropion-SR
3 CHANGE -it is About Life Completed NCT01585493 Phase 3
4 A Phase III Study of Eszopiclone in Patients With Insomnia (Study SEP 190-150) Completed NCT00770692 Phase 3 Eszopiclone 1 mg- Elderly;Eszopiclone 2 mg- Elderly;Eszopiclone 3 mg- Non-elderly;Eszopiclone 2 mg- Non-elderly
5 Detection and Treatment of Depression in Patients Admitted to the General Hospital Unknown status NCT00521911 Phase 2
6 Establishment of Cessation Therapy by Clinical Trials for Subjects With Betel-quid Dependence and Oral Pre-cancer Active, not recruiting NCT03010761 Phase 2 escitalopram;Moclobemide;Placebo - Cap
7 Developing and Implementing an Interdisciplinary Team-Based Care Approach (ITCA-ThyCa) for Thyroid Cancer Patients Withdrawn NCT01994200 Phase 1, Phase 2
8 A Bioequivalence and Food Effect Study of SEP-190 in Japanese Healthy Subjects (Study SEP 190-102) Completed NCT01055834 Phase 1 Eszopiclone 3 mg;Eszopiclone 1 mg
9 Effect of Combined Exercise Post-treatment Intervention in Lean Mass Recovery in Breast Cancer Survival. Unknown status NCT01843608
10 Get Moving and Get Well - Pilot Study Unknown status NCT01884025
11 Impact of Hospital Admission on Patients With Dementia Unknown status NCT02483065
12 Mind Body Therapy During Geriatric Rehabilitation Unknown status NCT01074788
13 Treatment of Depressed Adolescents With Physical Illness Completed NCT00446238
14 Effectiveness of a Self-care Intervention for Depression in Primary Care Patients With Chronic Physical Illnesses Completed NCT01521013
15 Understanding and Treating Neuropsychiatric Symptoms of Pediatric Physical Illness Completed NCT00769353
16 Depression, Genes, Cytokines, Chronic Fatigue, Physical Illnesses and Quality of Life Completed NCT02943330
17 Study Of Telemedicine Consultation at Home For Older Adults Completed NCT01324687
18 Laser Therapy, Pain and Carpometacarpal Joint Osteoarthritis Treatment Completed NCT03270488
19 Influence of Multi-dimensional Wellness Program on Quality of Life Completed NCT01927250
20 Safety/Effectiveness Study of a Single Session of Laying-on-of-hands in Various Settings in Japan Completed NCT01316029
21 Evaluation of the Texas Wellness Incentives and Navigation (WIN) Project Completed NCT02440906
22 Randomized Controlled Trial of Mind-Body Breathing Therapy (in Chronic Obstructive Pulmonary Disease) To Improve Palliation of Dyspnea and Health-Related Quality of Life Completed NCT00243282
23 Auriculotherapy on Lower Urinary Tract Symptoms in Elderly Men Completed NCT02330107
24 Life Quality and Health in Patients With Klinefelter Syndrome Completed NCT01690013
25 Phospholipid Hypothesis of Depression: From Molecular Biology, Neuroimaging to Behaviour Completed NCT02615405
26 Stress Management Program for World Trade Center (WTC) Responders Completed NCT02457780
27 The Effect of Transcranial Direct Current Stimulation on Human Brains: A Neuroimaging Study Completed NCT02421146
28 Evaluation of Telehealth Interventions for Post-Trauma Stress Completed NCT00350584
29 MAPS Group Therapy Model for Bipolar Disorder Completed NCT01152034
30 Evaluation of a Gamified Electronic Medication Administration Record (eMAR) System Recruiting NCT03219151
31 Communitas: A Program for Teens Living With Chronic Illness and Their Families Recruiting NCT03170167
32 Peer Navigators to Address Obesity-Related Concerns for African Americans With Serious Mental Illness Recruiting NCT03382782
33 Reducing Depressive Symptoms in Physically Ill Youth Active, not recruiting NCT00534911
34 Cancer Caregiver Burden: Targeting Emotion Regulation in a Trial Active, not recruiting NCT02322905
35 Evaluation of Peer Specialists on VA PACTs Enrolling by invitation NCT02732600
36 Mindful Mental Training for Surgeons to Enhance Resilience and Performance Under Stress Enrolling by invitation NCT03141190
37 Efficacy of Neuromuscular Electrical Stimulation in Geriatric Population Not yet recruiting NCT03409575
38 Effectiveness of a Psychoeducational Group Intervention in Patients With Depression and Physical Comorbidity Not yet recruiting NCT03243799
39 [18 Fluorine(F)]DOPA Determinants and Predictors of Treatment Response in Psychosis Not yet recruiting NCT02880995 6 weeks of treatment with amisulpride
40 Self-Management Training and Automated Telehealth to Improve SMI Health Outcomes Not yet recruiting NCT02188732
41 Evaluation of a Simulation-Based Educational Tool for Personalized Feedback in Insulin Therapy Management Terminated NCT01767831

Search NIH Clinical Center for Physical Disorder

Genetic Tests for Physical Disorder

Anatomical Context for Physical Disorder

MalaCards organs/tissues related to Physical Disorder:

38
Brain, Testes, Breast, Thyroid, Eye

Publications for Physical Disorder

Articles related to Physical Disorder:

(show all 27)
# Title Authors Year
1
Invited Commentary: Observing Neighborhood Physical Disorder in an Age of Technological Innovation. ( 28899029 )
2017
2
Neighborhood Physical Disorder and Psychological Distress: Does the Risk Increase With Age? ( 27913760 )
2016
3
The role of neighborhood disadvantage, physical disorder, and collective efficacy in adolescent alcohol use: a multilevel path analysis. ( 27521816 )
2016
4
Neighborhood Physical Disorder in New York City. ( 27482283 )
2016
5
Validity of an ecometric neighborhood physical disorder measure constructed by virtual street audit. ( 25122584 )
2014
6
Neighborhood physical disorder, social cohesion, and insomnia: results from participants over age 50 in the Health and Retirement Study. ( 25222023 )
2014
7
Intellectual disability and co-occurring mental health and physical disorders in aggressive behaviour. ( 23952483 )
2013
8
Social cohesion and self-rated health: The moderating effect of neighborhood physical disorder. ( 24048811 )
2013
9
The alexithymic brain: the neural pathways linking alexithymia to physical disorders. ( 23302233 )
2013
10
Erratum on "Eyes on the block: Measuring urban physical disorder through in person observation, by Malia Jones, Anne R. Pebley, Narayan Sastry, Social Science Research 40 (2) 523-537". ( 23017767 )
2012
11
Child maltreatment increases sensitivity to adverse social contexts: neighborhood physical disorder and incident binge drinking in Detroit. ( 21981990 )
2012
12
Eyes on the Block: Measuring Urban Physical Disorder Through In-Person Observation. ( 21643484 )
2011
13
Do children with developmental disabilities and mental health conditions have greater difficulty using health services than children with physical disorders? ( 20364366 )
2011
14
Misdemeanor policing, physical disorder, and gun-related homicide: a spatial analytic test of "broken-windows" theory. ( 19525689 )
2009
15
The association of sidewalk walkability and physical disorder with area-level race and poverty. ( 17933956 )
2007
16
Block observations of neighbourhood physical disorder are associated with neighbourhood crime, firearm injuries and deaths, and teen births. ( 16166368 )
2005
17
Review of aetiological concepts of temporomandibular pain disorders: towards a biopsychosocial model for integration of physical disorder factors with psychological and psychosocial illness impact factors. ( 15978854 )
2005
18
Physical disorder and optical properties in the vacuum ultraviolet region of amorphous SiO(2). ( 11690278 )
2001
19
Well sibling psychological adjustment to chronic physical disorder in a sibling: how important is maternal awareness of their illness attitudes and perceptions? ( 11693590 )
2001
20
Excessive health behaviors in those at risk for physical disorder. ( 9304547 )
1997
21
Emotional coping, age, and physical disorder. ( 2364177 )
1990
22
Type A behavior as a general risk factor for physical disorder. ( 3050117 )
1988
23
Psychological investigation of genital herpes recurrence: prospective assessment and cognitive-behavioral intervention for a chronic physical disorder. ( 3383831 )
1988
24
The other part of the elephant. Mental disorder screening in primary health care settings and physical disorder screening in psychiatric settings. ( 3431175 )
1987
25
Detection of physical disorder in newly admitted psychiatric patients. ( 3812010 )
1986
26
Physical disorder among day hospital patients. ( 667504 )
1978
27
Physical Disorder in 164 Admissions to a Mental Hospital. ( 20780853 )
1937

Variations for Physical Disorder

Expression for Physical Disorder

Search GEO for disease gene expression data for Physical Disorder.

Pathways for Physical Disorder

Pathways related to Physical Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.38 IRF6 MSX1 NODAL SHH
2 9.75 GLI3 NODAL SHH

GO Terms for Physical Disorder

Biological processes related to Physical Disorder according to GeneCards Suite gene sharing:

(show all 48)
# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.94 GLI3 MCPH1 SATB2 SHH
2 central nervous system development GO:0007417 9.88 GLI3 NHLH1 SHH
3 brain development GO:0007420 9.88 GLI3 NODAL PAFAH1B1 SIX3 ZIC2
4 lung development GO:0030324 9.84 GLI3 NODAL SHH
5 cerebral cortex development GO:0021987 9.83 MCPH1 PAFAH1B1 WDR62
6 heart development GO:0007507 9.83 GLI3 MSX1 NODAL SHH SHOX2
7 forebrain development GO:0030900 9.82 GLI3 MSX1 SHH
8 camera-type eye development GO:0043010 9.82 GLI3 SHH SIX3
9 negative regulation of cell differentiation GO:0045596 9.81 GLI3 NODAL SHH
10 multicellular organism development GO:0007275 9.81 MSX1 NHLH1 NODAL PAFAH1B1 SATB2 SHH
11 embryonic digit morphogenesis GO:0042733 9.8 GLI3 MSX1 SHH
12 odontogenesis of dentin-containing tooth GO:0042475 9.78 GLI3 MSX1 SHH
13 cell development GO:0048468 9.77 IRF6 NODAL SHH
14 anterior/posterior pattern specification GO:0009952 9.76 GLI3 MSX1 NODAL SHH
15 palate development GO:0060021 9.71 GLI3 MSX1 SATB2 SHH
16 positive regulation of neuroblast proliferation GO:0002052 9.7 GLI3 SHH
17 establishment of mitotic spindle orientation GO:0000132 9.7 MCPH1 PAFAH1B1
18 embryonic forelimb morphogenesis GO:0035115 9.7 MSX1 SHH SHOX2
19 positive regulation of protein import into nucleus GO:0042307 9.69 GLI3 SHH
20 spinal cord motor neuron differentiation GO:0021522 9.69 GLI3 SHH
21 neuroblast proliferation GO:0007405 9.69 PAFAH1B1 SHH
22 osteoblast development GO:0002076 9.68 SATB2 SHH
23 prostate gland development GO:0030850 9.68 GLI3 SHH
24 anatomical structure development GO:0048856 9.68 GLI3 SHH
25 centriole replication GO:0007099 9.68 CEP63 WDR62
26 digestive tract morphogenesis GO:0048546 9.67 NODAL SHH
27 embryonic pattern specification GO:0009880 9.67 NODAL SATB2 SHH
28 layer formation in cerebral cortex GO:0021819 9.66 GLI3 PAFAH1B1
29 positive regulation of alpha-beta T cell differentiation GO:0046638 9.66 GLI3 SHH
30 negative thymic T cell selection GO:0045060 9.65 GLI3 SHH
31 artery development GO:0060840 9.63 GLI3 SHH
32 forebrain dorsal/ventral pattern formation GO:0021798 9.62 GLI3 SIX3
33 telencephalon regionalization GO:0021978 9.61 SHH SIX3
34 mesenchymal cell proliferation GO:0010463 9.58 MSX1 SHH
35 spinal cord dorsal/ventral patterning GO:0021513 9.58 GLI3 SHH
36 formation of anatomical boundary GO:0048859 9.57 NODAL SHH
37 regulation of odontogenesis GO:0042481 9.56 MSX1 SHH
38 hindgut morphogenesis GO:0007442 9.55 GLI3 SHH
39 negative regulation of alpha-beta T cell differentiation GO:0046639 9.54 GLI3 SHH
40 embryonic digestive tract morphogenesis GO:0048557 9.54 GLI3 SHH SHOX2
41 anatomical structure formation involved in morphogenesis GO:0048646 9.5 GLI3 NODAL SHH
42 embryonic morphogenesis GO:0048598 9.43 GLI3 SHH SHOX2
43 positive regulation of transcription by RNA polymerase II GO:0045944 9.32 GLI3 IRF6 MSX1 NHLH1 NODAL PIK3R2
44 embryonic limb morphogenesis GO:0030326 9.26 GLI3 MSX1 SHH SHOX2
45 regulation of transcription, DNA-templated GO:0006355 10.35 GLI3 IRF6 MSX1 NHLH1 SATB2 SHH
46 nervous system development GO:0007399 10.07 NODAL PAFAH1B1 SHOX2 WDR62 ZIC2
47 transcription by RNA polymerase II GO:0006366 10.07 GLI3 IRF6 MSX1 NHLH1 SATB2 SIX3
48 negative regulation of transcription by RNA polymerase II GO:0000122 10.05 GLI3 MCPH1 MSX1 NODAL SATB2 SHH

Molecular functions related to Physical Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.46 GLI3 MSX1 NHLH1 SATB2
2 sequence-specific DNA binding GO:0043565 9.1 GLI3 IRF6 MSX1 SATB2 SHOX2 SIX3
3 morphogen activity GO:0016015 8.96 NODAL SHH

Sources for Physical Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....