FTD
MCID: PCK001
MIFTS: 74

Pick's Disease (FTD) malady

Neuronal diseases category

Summaries for Pick's Disease

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42NIH Rare Diseases, 43NINDS, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Pick’s disease is a neurological condition characterized by a slowly progressive deterioration of behavior, personality, or language. people with pick's disease have abnormal substances (called pick bodies) inside nerve cells in the damaged areas of the brain. pick bodies contain an abnormal form of a protein called tau. this protein is found in all nerve cells, but people with pick's disease have an abnormal amount or type of this protein. symptoms often present sometime in the 50s, though it can occur as early as age 20 or as late as age 80. the course of the disease varies from person to person. the underlying cause of pick's disease is unknown. in some cases, the disease runs in families. while there is no treatment to slow the progression of the disease, medications can be used to treat individual symptoms. last updated: 2/5/2013

MalaCards: Pick's Disease, also known as pick disease, is related to niemann-pick disease and amyotrophic lateral sclerosis. An important gene associated with Pick's Disease is MAPT (microtubule-associated protein tau), and among its related pathways are Cholesterol and Sphingolipids transport / Generic schema (normal and CF) and Alzheimers Disease Pathway. The compounds thioflavin and thioflavine s have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and liver, and related mouse phenotypes are liver/biliary system and immune system.

NINDS:43 Frontotemporal dementia (FTD) describes a clinical syndrome associated with shrinking of the frontal and temporal anterior lobes of the brain. Originally known as Pick?s disease, the name and classification of FTD has been a topic of discussion for over a century.

Description from OMIM:46 172700,600274,600795,607485

Aliases & Classifications for Pick's Disease

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 22GTR, 43NINDS, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
frontotemporal dementia:
Inheritance: Autosomal dominant; Prevalence: 1-9/100000; Age of onset: Adulthood


Aliases & Descriptions:

pick's disease 8 42 43
pick disease 9 22 46
pick disease of the brain 42 60
frontotemporal dementia 48 60
picks disease 10 44
dementia with lobar atrophy and neuronal cytoplasmic inclusions 42
frontotemporal degeneration 60
dementia in pick's disease 8
lobar atrophy of the brain 42
lobar atrophy of brain 8
pick disease of brain 8
ftd 48


External Ids:

Disease Ontology8 DOID:11870
NCIt39 C85008
ICD9CM27 331.11
MESH via Orphanet35 D057180
ICD10 via Orphanet26 G31.0
SNOMED-CT via Orphanet57 230270009
UMLS via Orphanet61 C0338451
ICD1025 F02.0

Related Diseases for Pick's Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pick's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 189)
idRelated DiseaseScoreTop Affiliating Genes
1niemann-pick disease31.9NPC2, NPC1
2amyotrophic lateral sclerosis31.4MAPT, APP, PSEN1, SNCA
3lateral sclerosis31.4MAPT, SNCA
4myopathy31.1APP
5aphasia31.1MAPT
6niemann–pick disease30.9NPC2, LCAT, M6PR, NPC1, PSAP, CHIT1
7acid sphingomyelinase deficiency30.9SMPD1
8brain disease30.7SNCA, PSEN1, MAPT, HCRT, APP
9lysosomal storage disease30.6M6PR
10vascular dementia30.4SNCA, APP, PSEN1, MAPT
11parkinson's disease30.4MAPT, SNCA
12progressive supranuclear palsy30.3MAPT
13frontotemporal dementia30.3PSEN1, MAPT
14dementia30.3NPC1, PSEN1, HCRT, MAPT, CHIT1, SNCA
15huntington's disease30.3PSEN1, HCRT, MAPT, APP, SNCA
16sphingolipidosis30.1PSAP, NPC1, ASAH2
17lewy body dementia30.1SNCA, MAPT
18prion disease30.1HCRT, PSEN1
19normal pressure hydrocephalus30.1MAPT, HCRT
20cadasil30.1ABCA1, MAPT, CHIT1, PSEN1
21hydrocephalus30.1MAPT
22tauopathy29.9MAPT, SNCA, APP, PSEN1, NPC1
23amyloidosis29.9APP, SNCA, MAPT, PSEN1
24schizophrenia29.9APOD, PSEN1, SNCA, HCRT
25central nervous system disease29.9MAPT, APP, HCRT
26alzheimer's disease29.9SNCA, M6PR, APP, APOD, NPC1, SMPD1
27multiple system atrophy29.9MAPT, SNCA
28multiple sclerosis29.9HCRT, CHIT1
29motor neuron disease10.8
30inclusion body myopathy with early-onset paget disease and frontotemporal dementia10.8
31grn-related frontotemporal dementia10.7
32frontotemporal dementia with parkinsonism-1710.6
33liver disease10.6
34niemann-pick disease type c110.6
35amyotrophic lateral sclerosis with frontotemporal dementia10.6
36chmp2b-related frontotemporal dementia10.6
37frontotemporal dementia, chromosome 3-linked10.5
38niemann-pick disease type d10.5
39skin disease10.5
40inclusion body myopathy with paget disease of bone and/or frontotemporal dementia10.5
41neurologic diseases10.4
42neuronitis10.4
43niemann-pick disease type c210.4
44intracranial hypotension10.4
45paget's disease of bone10.4
46frontotemporal dementia, ubiquitin-positive10.4
47inclusion body myopathy with early-onset paget disease and frontotemporal dementia 110.4
48amyotrophic lateral sclerosis 14, with or without frontotemporal dementia10.4
49hepatitis10.4
50histiocytosis10.4

Graphical network of the top 20 diseases related to Pick's Disease:



Diseases related to pick's disease

Clinical Features for Pick's Disease

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46OMIM
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Clinical features from OMIM:

172700,600274,600795,607485

Clinical synopsis from OMIM:

172700

Drugs & Therapeutics for Pick's Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pick's Disease

Drug clinical trials:

Search ClinicalTrials for Pick's Disease

Search NIH Clinical Center for Pick's Disease

Search CenterWatch for Pick's Disease

Genetic Tests for Pick's Disease

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Sources:
22GTR
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Genetic tests related to Pick's Disease:

id Genetic test Affiliating Genes
1 Pick's Disease22

Anatomical Context for Pick's Disease

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32MalaCards
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MalaCards organs/tissues related to Pick's Disease:

32
Brain, Cortex, Liver, Lung, Spleen, Temporal lobe, Olfactory bulb, Amygdala

Animal Models for Pick's Disease or affiliated genes

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Sources:
36MGI
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Publications for Pick's Disease

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50PubMed
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Articles related to Pick's Disease:

(show top 50)    (show all 276)
idTitleAuthorsYear
1
Immunolocalization of an Amino-Terminal Fragment of Apolipoprotein E in the Pick's Disease Brain. (24312462)
2013
2
Frontotemporal dementia, Pick's disease. (20420119)
2010
3
Pick's disease with Pick bodies combined with progressive supranuclear palsy without tuft-shaped astrocytes: a clinical, neuroradiologic and pathological study of an autopsied case. (16771179)
2006
4
Pathological heterogeneity of the precentral gyrus in Pick's disease: a study of 16 autopsy cases. (16609852)
2006
5
Ubiquitin and ubiquitin-related proteins in the brains of patients with atypical Pick's disease without Pick bodies and dementia with motor neuron disease. (15641590)
2004
6
Severity of gliosis in Pick's disease and frontotemporal lobar degeneration: tau-positive glia differentiate these disorders. (12615642)
2003
7
Pick-body-like inclusions in corticobasal degeneration differ from Pick bodies in Pick's disease. (11810176)
2002
8
Morphometrical reappraisal of motor neuron system of Pick's disease and amyotrophic lateral sclerosis with dementia. (12070660)
2002
9
Human brain cytosolic histamine-N-methyltransferase is decreased in Down syndrome and increased in Pick's disease. (11880199)
2002
10
Structural analysis of Pick's disease-derived and in vitro-assembled tau filaments. (11290566)
2001
11
Frontotemporal dementia (Pick's disease): clinical features and assessment. (11402143)
2001
12
Rehabilitation applications in caring for patients with Pick's disease and frontotemporal dementias. (11402153)
2001
13
Transgenic mouse models of tauopathies: prospects for animal models of Pick's disease. (11402147)
2001
14
Tau gene mutation K257T causes a tauopathy similar to Pick's disease. (11089577)
2000
15
Clustering of Pick bodies in the dentate gyrus in Pick's disease. (11132931)
2000
16
The spatial patterns of Pick bodies, Pick cells and Alzheimer's disease pathology in Pick's disease. (19519649)
1999
17
Neuronal and glial DNA fragmentation in Pick's disease. (10412801)
1999
18
Ubiquitin-immunohistochemical investigation of atypical Pick's disease without Pick bodies. (9741407)
1998
19
Pick's disease with amyotrophic lateral sclerosis (ALS): report of two autopsy cases and literature review. (9125397)
1997
20
Pick complex: too simple?; Commentary on "Pick complex and Pick's disease: the nosology of frontal lobe dementia, primary progressive aphasia, and corticobasal ganglionic degeneration" by A. Kertesz*. (21284786)
1996
21
Primary progressive apraxia in Pick's disease: a clinicopathologic study. (8757022)
1996
22
Initial 'schizophrenia-like' psychosis in Pick's disease: case study with neuroimaging and neuropathology, and implications for frontotemporal dysfunction in schizophrenia. (8929764)
1995
23
Slowly progressive aphasia, a left temporal variant of probable Pick's disease: 15 years of follow-up. (7591688)
1995
24
Quantitative neuropathologic analysis of Pick's disease cases: cortical distribution of Pick bodies and coexistence with Alzheimer's disease. (8171960)
1994
25
Neurochemical and histopathologic alterations characteristic of Pick's disease in a non-demented individual. (8301318)
1994
26
Quantitative neuropathologic analysis of Pick's disease cases. (8171974)
1994
27
Familial Pick's disease and dementia in frontal lobe degeneration of non-Alzheimer type are not variants of prion disease. (8006666)
1994
28
Abnormal neuritic architecture identified by Di-I in Pick's disease. (8355029)
1993
29
A case of progressive aphasia without dementia: "temporal" Pick's disease? (2303835)
1990
30
Immunocytochemical and ultrastructural studies of Pick's disease. (2162145)
1990
31
Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodies in muscle, and mallory bodies in alcoholic liver disease. (2837558)
1988
32
Studies on neurotransmitter markers of the basal ganglia in Pick's disease, with special reference to dopamine reduction. (2450180)
1988
33
Cortical degeneration with swollen chromatolytic neurons: its relationship to Pick's disease. (3958759)
1986
34
Neurochemical enzyme changes in Alzheimer's and Pick's disease. (6089677)
1984
35
Studies on lipids from liver and spleen of a child (O.L.) with Niemann-Pick's disease type C. (6716060)
1984
36
Brain trace elements in Pick's disease. (6712183)
1984
37
Computed tomography in Pick's disease: findings in a family affected in three consecutive generations. (7142506)
1982
38
Neurochemical observations in a case of Pick's disease. (7431041)
1980
39
A new case of Pick's disease. Anatomical and ultrastructural studies. (7188821)
1980
40
Case report: Neimann Pick's disease. (750474)
1978
41
Clinical neuropathological conference. Pick's disease. (4122430)
1973
42
Pick's disease. (5196476)
1969
43
Abnormal gangliosides in Tay-Sachs disease, Niemann-Pick's disease, and gargoylism. (4959256)
1966
44
Pick's disease in old age. (13968367)
1962
45
Tay-Sachs' disease with visceral involvement and its relationship to Niemann-Pick's disease. (14427628)
1959
46
Re-examination of a family with Pick's disease. (14442619)
1959
47
Alzheimer's disease-Pick's disease; a clinical analysis of 72 cases. (14902566)
1951
48
Niemann-Pick's disease and its relationship to the lipoidoses. (15398896)
1950
49
Pick's disease; general survey and report of a case with chronic chorea. (18138863)
1949
50
Chronic Increased Intrapericardial Pressure (Pick's Disease). (21407464)
1934

Genetic Variations for Pick's Disease

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Pick's Disease:

62
id Symbol AA change Variation ID SNP ID
1MAPTp.Lys574ThrVAR_010344
2MAPTp.Gly706ArgVAR_010352
3MAPTp.Ser637PheVAR_019665
4MAPTp.Lys686IleVAR_019668

Expression for genes affiliated with Pick's Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pick's Disease

Search GEO for disease gene expression data for Pick's Disease.

Pathways for genes affiliated with Pick's Disease

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Sources:
51QIAGEN, 29KEGG, 53Reactome, 37NCBI BioSystems Database, 4Cell Signaling Technology
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Pathways related to Pick's Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Cholesterol and Sphingolipids transport / Generic schema (normal and CF)
10.5NPC2, NPC1
210.4APP, PSEN1, MAPT
3
Hide members
10.4SMPD1, ASAH2, PSAP
4
Cholesterol and Sphingolipids transport / Distribution to the intracellular membrane compartments (normal and CF)
10.4NPC1, NPC2, RAB9A
510.4APP, PSEN1, SNCA, MAPT
6
Hide members
10.4LCAT, NPC1L1, ABCA1
710.4SMPD1, PSAP, NPC2, NPC1, M6PR

Compounds for genes affiliated with Pick's Disease

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44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Pick's Disease according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1thioflavin4410.9APP, SNCA, MAPT
2thioflavine s4410.9APP, SNCA, MAPT
3glucosylceramide44 2411.8SMPD1, ASAH2, CHIT1, PSAP, NPC2
4ganglioside4410.8SMPD1, PSAP, NPC2, NPC1, APP
54-hydroxynonenal44 2411.8LCAT, APP, PSEN1, SNCA, MAPT
6choline44 11 2412.8APP, PSEN1, PSAP, SNCA, MAPT, ABCA1
7sterol4410.8LCAT, NPC1, NPC2, NPC1L1, PSEN1, ABCA1
8methionine sulfoxide44 11 2412.8ABCA1, SNCA, APP
9lactacystin4410.8APP, PSEN1, SNCA, MAPT, ABCA1
10carbachol44 28 1112.8APP, PSEN1, SNCA, MAPT, HCRT
11valine4410.8APP, PSEN1, PSAP, SNCA, MAPT
12mannose 6-phosphate44 2411.8M6PR, NPC1, PSAP, RAB9A, SMPD1
13methionine4410.8LCAT, PSEN1, SNCA, MAPT, ABCA1, SMPD1
14sphingosine44 11 2412.8NPC2, PSAP, ASAH2, SMPD1
15formate4410.8APP, SNCA, MAPT
16sodium dodecylsulfate4410.8MAPT, SNCA, APP, LCAT
17phosphatidylcholine4410.8LCAT, NPC1, SNCA, ABCA1, SMPD1
18monensin4410.8SMPD1, ABCA1, M6PR
19phospholipid4410.8LCAT, APOD, PSAP, SNCA, ABCA1, SMPD1
20glycolipid4410.8PSAP, NPC2, NPC1
21tmao4410.7SNCA, MAPT
22testosterone44 59 11 2413.7LCAT, APP, APOD, PSAP, SNCA, MAPT
23cysteine4410.7M6PR, LCAT, APP, NPC1, PSEN1, PSAP
24ceramide4410.7SMPD1, ASAH2, ABCA1, PSAP
25arginine4410.7M6PR, APP, PSEN1, PSAP, SNCA, MAPT
26glucose4410.7APOD, PSEN1, PSAP, SNCA, MAPT, HCRT
27glutamine4410.7LCAT, APP, PSEN1, SNCA, MAPT
28glutamate4410.7LCAT, APP, PSEN1, SNCA, MAPT, HCRT
2924s-hydroxy-cholesterol4410.7ABCA1, APP
30alanine4410.7LCAT, CCL18, APP, PSEN1, SNCA, MAPT
31phosphatidylserine44 28 1112.7ABCA1, MAPT, SNCA, PSAP
32oligonucleotide4410.7APOD, PSEN1, PSAP, HCRT, ABCA1, SMPD1
33dihydroceramide44 2411.7SMPD1, ASAH2, NPC2
34u18666a4410.7APP, NPC1
35serine4410.7M6PR, LCAT, APP, PSEN1, PSAP, SNCA
36thioflavin t4410.7SNCA, APP
37fatty acid4410.7LCAT, APOD, SNCA, ABCA1, ASAH2
38tacrine44 1111.6MAPT, APP
39cholesterol44 28 11 2413.6RAB9A, ABCA1, HCRT, SNCA, PSAP, PSEN1
40lipid4410.6SMPD1, M6PR, LCAT, ASAH2, RAB9A, ABCA1
41atp44 2811.6NPC1, NPC1L1, PSAP, HCRT, ABCA1, SMPD1
42h2o24410.6APP, PSEN1, SNCA, MAPT, SMPD1
43nmda44 2811.6APP, PSEN1, MAPT, HCRT
44donepezil44 11 2412.6MAPT, APP
45norepinephrine44 11 2412.5APP, PSEN1, SNCA, HCRT
46glycogen44 2411.4MAPT, SNCA, PSEN1, M6PR
47acetylcholine44 49 28 11 2414.4HCRT, MAPT, SNCA, APP
48alpha tocopherol4410.3LCAT, SNCA, ABCA1
49memantine44 28 1112.1MAPT, APP

GO Terms for genes affiliated with Pick's Disease

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16Gene Ontology
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Cellular components related to Pick's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1rough endoplasmic reticulumGO:00579110.6HCRT, SNCA, PSEN1
2perinuclear region of cytoplasmGO:04847110.6APP, APOD, NPC1, PSEN1, SNCA, HCRT
3axonGO:03042410.6APP, PSEN1, SNCA, MAPT
4extracellular regionGO:00557610.5HCRT, LCAT, APP, APOD, NPB, NPC1
5Golgi apparatusGO:00579410.5APP, NPC1, PSEN1, PSAP, SNCA, ABCA1
6lysosomeGO:00576410.5NPC1, NPC2, CHIT1, RAB9A
7growth coneGO:03042610.4MAPT, SNCA, PSEN1
8ciliary rootletGO:03525310.3PSEN1, APP
9extracellular spaceGO:00561510.3LCAT, CCL18, APOD, PSAP, CHIT1, SMPD1
10lysosomal membraneGO:00576510.1M6PR, NPC1, PSEN1, PSAP

Biological processes related to Pick's Disease according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1cholesterol transportGO:03030110.7NPC1L1, NPC2, NPC1, LCAT
2cholesterol effluxGO:03334410.7ABCA1, NPC2, NPC1
3cholesterol homeostasisGO:04263210.7LCAT, NPC1, NPC2, NPC1L1, ABCA1
4smooth endoplasmic reticulum calcium ion homeostasisGO:05156310.6PSEN1, APP
5cholesterol metabolic processGO:00820310.6LCAT, APP, NPC1, NPC2, ABCA1
6response to drugGO:04249310.6APOD, NPC1, NPC1L1, SNCA, SMPD1
7lipoprotein metabolic processGO:04215710.6LCAT, NPC1L1, ABCA1
8glycosphingolipid metabolic processGO:00668710.6SMPD1, ASAH2, PSAP
9intracellular cholesterol transportGO:03236710.6NPC2, ABCA1
10negative regulation of platelet-derived growth factor receptor signaling pathwayGO:01064210.5SNCA, APOD
11positive regulation of receptor recyclingGO:00192110.4SNCA, PSEN1
12reverse cholesterol transportGO:04369110.4ABCA1, LCAT
13sphingolipid metabolic processGO:00666510.3PSAP, ASAH2, SMPD1
14axon cargo transportGO:00808810.1MAPT, APP

Molecular functions related to Pick's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholesterol bindingGO:01548510.5ABCA1, NPC2, NPC1, APOD
2apolipoprotein bindingGO:03418510.4ABCA1, MAPT
3apolipoprotein A-I bindingGO:03418610.3ABCA1, LCAT
4protein bindingGO:00551510.2NPC1, NPB, APOD, APP, CCL18, LCAT
5hedgehog receptor activityGO:00815810.1NPC1L1, NPC1

Products for genes affiliated with Pick's Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pick's Disease

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet