FTD
MCID: PCK001
MIFTS: 70

Pick's Disease (FTD) malady

Genetic diseases, Rare diseases, Mental diseases, Neuronal diseases categories

Summaries for Pick's Disease

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44NIH Rare Diseases, 45NINDS, 48OMIM, 34MalaCards
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NIH Rare Diseases:44 Pick’s disease is a neurological condition characterized by a slowly progressive deterioration of behavior, personality, or language. people with pick's disease have abnormal substances (called pick bodies) inside nerve cells in the damaged areas of the brain. pick bodies contain an abnormal form of a protein called tau. this protein is found in all nerve cells, but people with pick's disease have an abnormal amount or type of this protein. symptoms often present sometime in the 50s, though it can occur as early as age 20 or as late as age 80. the course of the disease varies from person to person. the underlying cause of pick's disease is unknown. in some cases, the disease runs in families. while there is no treatment to slow the progression of the disease, medications can be used to treat individual symptoms. last updated: 2/5/2013

MalaCards: Pick's Disease, also known as pick disease, is related to frontotemporal dementia and dementia. An important gene associated with Pick's Disease is MAPT (microtubule-associated protein tau), and among its related pathways are Alzheimers Disease Pathway and Cholesterol and Sphingolipids transport Distribution to the intracellular membrane compartments normal and CF . The compounds sterol and Tetrahexosylceramide (d18:1/12:0) have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and cortex, and related mouse phenotypes are respiratory system and cellular.

NINDS:45 Frontotemporal dementia (FTD) describes a clinical syndrome associated with shrinking of the frontal and temporal anterior lobes of the brain. Originally known as Pick?s disease, the name and classification of FTD has been a topic of discussion for over a century.

Description from OMIM:48 172700,600274,600795,607485

Aliases & Classifications for Pick's Disease

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50Orphanet, 63UMLS, 9Disease Ontology, 44NIH Rare Diseases, 45NINDS, 10diseasecard, 23GTR, 48OMIM, 11DISEASES, 46Novoseek, 36MeSH, 59SNOMED-CT, 41NCIt, 28ICD9CM, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Mental diseases, Neuronal diseases


Characteristics (Orphanet epidemiological data):

50
frontotemporal dementia:
Inheritance: Autosomal dominant; Prevalence: 1-9/100000; Age of onset: Adulthood


Aliases & Descriptions:

pick's disease 9 44 45
pick disease 9 10 23 48
pick disease of the brain 44 63
frontotemporal dementia 50 63
picks disease 11 46
dementia with lobar atrophy and neuronal cytoplasmic inclusions 44
frontotemporal degeneration 63
dementia in pick's disease 9
lobar atrophy of the brain 44
lobar atrophy of brain 9
pick disease of brain 9
ftd 50


External Ids:

Disease Ontology9 DOID:11870
NCIt41 C85008
ICD9CM28 331.11
MESH via Orphanet37 D057180
ICD10 via Orphanet27 G31.0
SNOMED-CT via Orphanet60 230270009
UMLS via Orphanet64 C0338451
ICD1026 F02.0

Related Diseases for Pick's Disease

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18GeneCards, 19GeneDecks
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Diseases related to Pick's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 170)
idRelated DiseaseScoreTop Affiliating Genes
1frontotemporal dementia32.4PSEN1, MAPT
2dementia32.3HCRT, CHIT1, PSEN1, MAPT, NPC2, NPC1
3niemann-pick disease32.1NPC2, NPC1
4semantic dementia31.3MAPT
5alzheimer's disease31.2HCRT, SMPD1, APOD, MPZ, CHIT1, ASAH2
6progressive supranuclear palsy31.2MAPT, HCRT
7acid sphingomyelinase deficiency31.1SMPD1
8tauopathy31.0NPC1, MAPT, PSEN1
9parkinson's disease30.5HCRT, PSEN1, MAPT
10huntington's disease30.4MAPT, PSEN1, HCRT
11lysosomal storage disease30.3SMPD1, NAGA, CHIT1, NPC1
12normal pressure hydrocephalus30.3MAPT, HCRT
13prion disease30.3PSEN1, MAPT
14vascular dementia30.2PSEN1, MAPT
15memory impairment30.2MAPT, PSEN1
16sphingolipidosis30.2NPC1, ASAH2
17multiple sclerosis29.8CHIT1, MPZ, HCRT
18amyotrophic lateral sclerosis11.0
19lateral sclerosis11.0
20neuronitis10.9
21motor neuron disease10.8
22myopathy10.8
23inclusion body myopathy with early-onset paget disease and frontotemporal dementia10.8
24aphasia10.8
25grn-related frontotemporal dementia10.8
26primary progressive aphasia10.7
27corticobasal degeneration10.7
28amyotrophic lateral sclerosis with frontotemporal dementia10.7
29niemann-pick disease type c110.7
30frontotemporal dementia with parkinsonism-1710.6
31schizophrenia10.6
32chmp2b-related frontotemporal dementia10.6
33cerebritis10.6
34niemann-pick disease type d10.5
35frontotemporal dementia, chromosome 3-linked10.5
36inclusion body myopathy with paget disease of bone and/or frontotemporal dementia10.5
37niemann-pick disease type c210.4
38intracranial hypotension10.4
39frontotemporal dementia, ubiquitin-positive10.4
40inclusion body myopathy with early-onset paget disease and frontotemporal dementia 110.4
41amyotrophic lateral sclerosis 14, with or without frontotemporal dementia10.4
42paget's disease of bone10.4
43lewy body dementia10.4
44pathological gambling10.4
45bipolar disorder10.4
46tardbp-related frontotemporal dementia10.4
47inclusion body myopathy wtih early-onset paget disease without frontotemporal dementia 310.4
48hepatitis10.3
49histiocytosis10.3
50sea-blue histiocytosis10.3

Graphical network of the top 20 diseases related to Pick's Disease:



Diseases related to pick's disease

Symptoms for Pick's Disease

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48OMIM
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Symptoms by clinical synopsis from OMIM:

172700

Clinical features from OMIM:

172700,600274,600795,607485

Drugs & Therapeutics for Pick's Disease

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Pick's Disease

Drug clinical trials:

Search ClinicalTrials for Pick's Disease

Search NIH Clinical Center for Pick's Disease

Search CenterWatch for Pick's Disease

Genetic Tests for Pick's Disease

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23GTR
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Genetic tests related to Pick's Disease:

id Genetic test Affiliating Genes
1 Pick's Disease23

Anatomical Context for Pick's Disease

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34MalaCards
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MalaCards organs/tissues related to Pick's Disease:

34
Brain, Liver, Cortex, Lung, Spleen, Amygdala, Olfactory bulb

Animal Models for Pick's Disease or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Pick's Disease:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.8HCRT, SMPD1, PSEN1, NPC2, NPC1
2MP:00053848.5NPC1, NPC2, MAPT, PSEN1, MPZ, SMPD1
3MP:00053978.2SMPD1, MPZ, PSEN1, MAPT, NPC2, NPC1
4MP:00053787.7UGT8, HCRT, SMPD1, PSEN1, MAPT, NPC2
5MP:00053877.6UGT8, SMPD1, MPZ, CHIT1, PSEN1, MAPT
6MP:00107687.5UGT8, SMPD1, APOD, MPZ, PSEN1, MAPT
7MP:00053867.2UGT8, HCRT, SMPD1, APOD, MPZ, PSEN1
8MP:00036317.2UGT8, HCRT, SMPD1, APOD, MPZ, PSEN1
9MP:00053765.8NPC1L1, UGT8, HCRT, SMPD1, APOD, MPZ

Publications for Pick's Disease

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53PubMed
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Articles related to Pick's Disease:

(show top 50)    (show all 270)
idTitleAuthorsYear
1
Neuronal and glial tau pathology in early frontotemporal lobar degeneration-tau, Pick's disease subtype. (20022024)
2010
2
Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains. (19693433)
2009
3
Pick's disease with Pick bodies combined with progressive supranuclear palsy without tuft-shaped astrocytes: a clinical, neuroradiologic and pathological study of an autopsied case. (16771179)
2006
4
Notch-1 immunoexpression is increased in Alzheimer's and Pick's disease. (16473372)
2006
5
The corpus callosum in Pick's disease, Alzheimer's disease, and amyotrophic lateral sclerosis: gliosis implies possible clinical consequence. (16526588)
2006
6
Presenile dementia mimicking Pick's disease: an autopsy case of localized amygdala degeneration with character change and emotional disorder. (16193841)
2005
7
Metalloproteinase ADAMTS-1 but not ADAMTS-5 is manifold overexpressed in neurodegenerative disorders as Down syndrome, Alzheimer's and Pick's disease. (15661359)
2005
8
An N-terminal fragment of ProSAAS (a granin-like neuroendocrine peptide precursor) is associated with tau inclusions in Pick's disease. (12914799)
2003
9
Clinicopathological study of two subtypes of Pick's disease in Japan. (12457075)
2003
10
Severity of gliosis in Pick's disease and frontotemporal lobar degeneration: tau-positive glia differentiate these disorders. (12615642)
2003
11
Preservation of nigral neurons in Pick's disease with Pick bodies: a clinicopathological and morphometric study of five autopsy cases. (11809165)
2002
12
Biochemical analysis of tau proteins in argyrophilic grain disease, Alzheimer's disease, and Pick's disease : a comparative study. (12368187)
2002
13
Pick's disease: a clinical overview. (11402142)
2001
14
Structural analysis of Pick's disease-derived and in vitro-assembled tau filaments. (11290566)
2001
15
Neuropathological discrepancy between Japanese Pick's disease without Pick bodies and frontal lobe degeneration type of frontotemporal dementia proposed by Lund and Manchester Group. (10935442)
2000
16
Immunohistochemistry distinguishes: between Pick's disease and corticobasal degeneration. (11185644)
2000
17
The spatial patterns of Pick bodies, Pick cells and Alzheimer's disease pathology in Pick's disease. (19519649)
1999
18
Tau-positive glial inclusions in progressive supranuclear palsy, corticobasal degeneration and Pick's disease. (10517506)
1999
19
Pick's disease: selective occurrence of apolipoprotein E-immunoreactive Pick bodies in the limbic system. (9452816)
1998
20
Vulnerable neuronal subsets in Alzheimer's and Pick's disease are distinguished by their tau isoform distribution and phosphorylation. (9485060)
1998
21
Cognitive, neuroimaging, and pathological studies in a patient with Pick's disease. (9485069)
1998
22
Pick's disease with amyotrophic lateral sclerosis. (9415547)
1997
23
Pick's disease with amyotrophic lateral sclerosis (ALS): report of two autopsy cases and literature review. (9125397)
1997
24
Specific pathological Tau protein variants characterize Pick's disease. (8786374)
1996
25
Pick's disease: hyperphosphorylated tau protein segregates to the somatoaxonal compartment. (8960316)
1996
26
Initial 'schizophrenia-like' psychosis in Pick's disease: case study with neuroimaging and neuropathology, and implications for frontotemporal dysfunction in schizophrenia. (8929764)
1995
27
Slowly progressive aphasia, a left temporal variant of probable Pick's disease: 15 years of follow-up. (7591688)
1995
28
Morphological overlap between corticobasal degeneration and Pick's disease: a clinicopathological report. (7885345)
1995
29
Neuropathologic changes of the temporal pole in Alzheimer's disease and Pick's disease. (8304839)
1994
30
Microglial reaction in Pick's disease. (8255555)
1993
31
Panencephalopathic type of Creutzfeldt-Jakob disease with neuropathologic features similar to Pick's disease. (7679958)
1993
32
A case of early-onset Pick's disease. (1429481)
1992
33
Altered serotonergic and cholinergic synaptic markers in Pick's disease. (1898253)
1991
34
Pick's disease: a case clinically resembling amyotrophic lateral sclerosis. (1944916)
1991
35
Selective loss of nigral neurons in Pick's disease: a morphometric study. (2082655)
1990
36
Isolation of the insoluble straight fibrils of Pick's disease. (3681329)
1987
37
Neurochemical enzyme changes in Alzheimer's and Pick's disease. (6089677)
1984
38
Studies on lipids from liver and spleen of a child (O.L.) with Niemann-Pick's disease type C. (6716060)
1984
39
Basal nucleus of Meynert. A neuropathological study in Alzheimer's disease, simple senile dementia, Pick's disease and Huntington's chorea. (6230416)
1983
40
Lack of cholinergic deficit in the neocortex in Pick's disease. (6141615)
1983
41
Computed tomography in Pick's disease: findings in a family affected in three consecutive generations. (7142506)
1982
42
Two autopsy cases of Pick's disease with neurofibrillary tangles. (7095671)
1982
43
Neurochemical observations in a case of Pick's disease. (7431041)
1980
44
Niemann--Pick's disease. (5366306)
1969
45
Fine structure of the Pick and Hirano bodies in a case of Pick's disease. (4179487)
1968
46
Electron microscopic structure of the "inclusion bodies" in Pick's disease. (4178657)
1968
47
Another case of Niemann-Pick's disease observed in Denmark. (12976123)
1952
48
Niemann-Pick's disease. (18137802)
1949
49
Niemann-Pick's disease; report of case. (20274455)
1946
50
PERICARDITIC PSEUDO-CIRRHOSIS OF THE LIVER, OR PICK'S DISEASE. (20774453)
1929

Variations for Pick's Disease

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65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar)
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UniProtKB/Swiss-Prot genetic disease variations for Pick's Disease:

65
id Symbol AA change Variation ID SNP ID
1MAPTp.Lys574ThrVAR_010344
2MAPTp.Gly706ArgVAR_010352
3MAPTp.Ser637PheVAR_019665
4MAPTp.Lys686IleVAR_019668

Clinvar genetic disease variations for Pick's Disease:

1 (show all 19)
id Gene Name Type Significance SNP ID Assembly Location
1MAPTNM_016835.4(MAPT): c.1853C> T (p.Pro618Leu)single nucleotide variantPathogenicrs63751273GRCh37Chr 17, 44087755: 44087755
2MAPTNM_016835.4(MAPT): c.1766G> T (p.Gly589Val)single nucleotide variantPathogenicrs63750376GRCh37Chr 17, 44074023: 44074023
3MAPTNM_016835.4(MAPT): c.2167C> T (p.Arg723Trp)single nucleotide variantPathogenicrs63750424GRCh37Chr 17, 44101427: 44101427
4MAPTNM_016835.4(MAPT): c.1866+14C> Tsingle nucleotide variantPathogenicrs63750972GRCh37Chr 17, 44087782: 44087782
5MAPTNM_016835.4(MAPT): c.1960G> A (p.Val654Met)single nucleotide variantPathogenicrs63750570GRCh37Chr 17, 44095995: 44095995
6MAPTNM_016835.4(MAPT): c.1788T> G (p.Asn596Lys)single nucleotide variantPathogenicrs63750756GRCh37Chr 17, 44087690: 44087690
7MAPTNM_016835.4(MAPT): c.1865G> A (p.Ser622Asn)single nucleotide variantPathogenicrs63751165GRCh37Chr 17, 44087767: 44087767
8MAPTNM_016835.4(MAPT): c.2116G> A (p.Gly706Arg)single nucleotide variantPathogenicrs63750512GRCh37Chr 17, 44101376: 44101376
9MAPTNM_016835.4(MAPT): c.1852C> T (p.Pro618Ser)single nucleotide variantPathogenicrs63751438GRCh37Chr 17, 44087754: 44087754
10MAPTNM_016835.4(MAPT): c.1839T> C (p.Asn613=)single nucleotide variantPathogenicrs63750912GRCh37Chr 17, 44087741: 44087741
11MAPTNM_016835.4(MAPT): c.1976A> T (p.Glu659Val)single nucleotide variantPathogenicrs63750711GRCh37Chr 17, 44096011: 44096011
12MAPTNM_016835.4(MAPT): c.1721A> C (p.Lys574Thr)single nucleotide variantPathogenicrs63750129GRCh37Chr 17, 44073978: 44073978
13MAPTNM_016835.4(MAPT): c.2057A> T (p.Lys686Ile)single nucleotide variantPathogenicrs63751264GRCh37Chr 17, 44096092: 44096092
14MAPTNM_016835.4(MAPT): c.14G> A (p.Arg5His)single nucleotide variantPathogenicrs63750959GRCh37Chr 17, 44039717: 44039717
15MAPTNM_016835.4(MAPT): c.1910C> T (p.Ser637Phe)single nucleotide variantPathogenicrs63750635GRCh37Chr 17, 44091652: 44091652
16MAPTNM_016835.4(MAPT): c.1747C> G (p.Leu583Val)single nucleotide variantPathogenicrs63750349GRCh37Chr 17, 44074004: 44074004
17MAPTNM_016835.4(MAPT): c.1901A> T (p.Lys634Met)single nucleotide variantPathogenicrs63750092GRCh37Chr 17, 44091643: 44091643
18PSEN1NM_000021.3(PSEN1): c.338T> C (p.Leu113Pro)single nucleotide variantPathogenicrs63751399GRCh37Chr 14, 73637755: 73637755
19PSEN1NM_000021.3(PSEN1): c.548G> T (p.Gly183Val)single nucleotide variantPathogenicrs63751068GRCh37Chr 14, 73653628: 73653628

Expression for genes affiliated with Pick's Disease

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pick's Disease

Search GEO for disease gene expression data for Pick's Disease.

Pathways for genes affiliated with Pick's Disease

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Sources:
51PathCards, 54QIAGEN, 61Thomson Reuters, 31KEGG, 56Reactome, 39NCBI BioSystems Database
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Compounds for genes affiliated with Pick's Disease

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46Novoseek, 25HMDB, 30IUPHAR, 12DrugBank
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Compounds related to Pick's Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 172)
idCompoundScoreTop Affiliating Genes
1sterol469.0NPC1L1, NPC2, PSEN1, NPC1
2Tetrahexosylceramide (d18:1/12:0)259.0SMPD1, NAGA, ASAH2, NPC2
3ganglioside469.0NPC1, MPZ, SMPD1, NPC2
4N-Stearoylsphingosine258.9ASAH2, UGT8, SMPD1, NPC2
5N-Lignoceroylsphingosine258.9NPC2, UGT8, ASAH2, SMPD1
6N-Palmitoylsphingosine258.9UGT8, SMPD1, ASAH2, NPC2
7Cer(d18:0/25:0)258.9NPC2, ASAH2, SMPD1, UGT8
8Cer(d18:0/26:0)258.9NPC2, ASAH2, SMPD1, UGT8
9Cer(d18:0/26:1(17Z))258.9NPC2, ASAH2, SMPD1, UGT8
10Cer(d18:0/24:1(15Z))258.9UGT8, SMPD1, NPC2, ASAH2
11Cer(d18:0/23:0)258.9ASAH2, SMPD1, UGT8, NPC2
12Cer(d18:0/24:0)258.8NPC2, ASAH2, SMPD1, UGT8
13Cer(d18:1/22:1(13Z))258.8UGT8, SMPD1, ASAH2, NPC2
14Cer(d18:1/23:0)258.8NPC2, ASAH2, SMPD1, UGT8
15Ceramide (t18:0/16:0)258.8NPC2, ASAH2, SMPD1, UGT8
16Cer(d18:1/14:0)258.8NPC2, ASAH2, SMPD1, UGT8
17Cer(d18:1/18:1(11Z))258.8NPC2, ASAH2, SMPD1, UGT8
18Cer(d18:0/12:0)258.8NPC2, UGT8, SMPD1, ASAH2
19Cer(d18:0/18:1(11Z))258.8NPC2, ASAH2, SMPD1, UGT8
20Cer(d18:0/18:0)258.8UGT8, SMPD1, ASAH2, NPC2
21Cer(d18:0/16:0)258.8UGT8, SMPD1, ASAH2, NPC2
22Cer(d18:0/14:0)258.8UGT8, SMPD1, ASAH2, NPC2
23Cer(d18:0/22:1(13Z))258.8UGT8, SMPD1, ASAH2, NPC2
24Cer(d18:0/22:0)258.8UGT8, SMPD1, ASAH2, NPC2
25Cer(d18:0/20:0)258.8UGT8, NPC2, ASAH2, SMPD1
26Cer(d18:0/18:1(9Z))258.8NPC2, ASAH2, SMPD1, UGT8
27Ceramide (d18:1/25:0)258.8SMPD1, ASAH2, NPC2, UGT8
28Ceramide (d18:1/24:1(15Z))258.8UGT8, SMPD1, ASAH2, NPC2
29Ceramide (d18:1/24:0)258.8UGT8, SMPD1, ASAH2, NPC2
30Ceramide (d18:1/26:0)258.8NPC2, ASAH2, UGT8, SMPD1
31Ceramide (d18:1/9Z-18:1)258.8UGT8, SMPD1, ASAH2, NPC2
32Ceramide (d18:1/26:1(17Z))258.7SMPD1, ASAH2, NPC2, UGT8
33glucosylceramide46 259.7NPC2, ASAH2, SMPD1, CHIT1
34Ceramide (d18:1/12:0)258.7NPC2, ASAH2, SMPD1, UGT8
35Ceramide (d18:1/18:0)258.7NPC2, ASAH2, SMPD1, UGT8
36Ceramide (d18:1/22:0)258.7UGT8, SMPD1, ASAH2, NPC2
37dihydroceramide46 259.7UGT8, ASAH2, SMPD1, NPC2
38Galactosylceramide (d18:1/22:0)258.7NPC2, SMPD1, UGT8, ASAH2
39Galactosylceramide (d18:1/20:0)258.7UGT8, SMPD1, ASAH2, NPC2
40glycolipid468.7UGT8, NPC1, NPC2, MPZ, NAGA
41Galactosylceramide (d18:1/18:1(9Z))258.7UGT8, SMPD1, ASAH2, NPC2
42Galactosylceramide (d18:1/26:1(17Z))258.6SMPD1, UGT8, NPC2, ASAH2
43Galactosylceramide (d18:1/24:1(15Z))258.6UGT8, SMPD1, ASAH2, NPC2
44Galactosylceramide (d18:1/18:0)258.6UGT8, SMPD1, NPC2, ASAH2
45Ceramide (d18:1/20:0)258.6UGT8, SMPD1, ASAH2, NPC2
46Galactosylceramide (d18:1/16:0)258.5SMPD1, UGT8, ASAH2, NPC2
47Ceramide (d18:1/16:0)258.4UGT8, SMPD1, ASAH2, NPC2
48glucose468.2HCRT, APOD, NAGA, PSEN1, MAPT, SMPD1
49cholesterol46 30 25 1211.0NPC1, NPC2, PSEN1, MPZ, APOD, NPC1L1
50lipid466.2NPC1L1, UGT8, HCRT, SMPD1, APOD, MPZ

GO Terms for genes affiliated with Pick's Disease

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17Gene Ontology
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Cellular components related to Pick's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1rough endoplasmic reticulumGO:0057919.8PSEN1, HCRT
2lysosomeGO:0057649.0NPC1, NPC2, CHIT1, NAGA
3perinuclear region of cytoplasmGO:0484718.9APOD, PSEN1, NPC1, HCRT
4endoplasmic reticulumGO:0057838.9PSEN1, NPC2, NPC1, APOD

Biological processes related to Pick's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholesterol effluxGO:0333449.8NPC1, NPC2
2cholesterol transportGO:0303019.7NPC1, NPC2, NPC1L1
3adult walking behaviorGO:0076289.6MAPT, NPC1
4axon cargo transportGO:0080889.6UGT8, MAPT
5glycosphingolipid metabolic processGO:0066879.3SMPD1, ASAH2
6response to drugGO:0424939.1APOD, NPC1, NPC1L1, SMPD1

Molecular functions related to Pick's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hedgehog receptor activityGO:0081589.8NPC1L1, NPC1
2cholesterol bindingGO:0154859.1NPC1, NPC2, APOD

Products for genes affiliated with Pick's Disease

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  • Antibodies
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Sources for Pick's Disease

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet