FTD
MCID: PCK001
MIFTS: 74

Pick's Disease (FTD) malady

Neuronal diseases category

Summaries for Pick's Disease

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42NIH Rare Diseases, 43NINDS, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Pick’s disease is a neurological condition characterized by a slowly progressive deterioration of behavior, personality, or language. people with pick's disease have abnormal substances (called pick bodies) inside nerve cells in the damaged areas of the brain. pick bodies contain an abnormal form of a protein called tau. this protein is found in all nerve cells, but people with pick's disease have an abnormal amount or type of this protein. symptoms often present sometime in the 50s, though it can occur as early as age 20 or as late as age 80. the course of the disease varies from person to person. the underlying cause of pick's disease is unknown. in some cases, the disease runs in families. while there is no treatment to slow the progression of the disease, medications can be used to treat individual symptoms. last updated: 2/5/2013

MalaCards: Pick's Disease, also known as pick disease, is related to niemann-pick disease and amyotrophic lateral sclerosis. An important gene associated with Pick's Disease is MAPT (microtubule-associated protein tau), and among its related pathways are Cholesterol and Sphingolipids transport / Generic schema (normal and CF) and Alzheimers Disease Pathway. The compounds thioflavin and thioflavine s have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and liver, and related mouse phenotypes are liver/biliary system and immune system.

NINDS:43 Frontotemporal dementia (FTD) describes a clinical syndrome associated with shrinking of the frontal and temporal anterior lobes of the brain. Originally known as Pick?s disease, the name and classification of FTD has been a topic of discussion for over a century.

Description from OMIM:46 172700,600274,600795,607485

Aliases & Classifications for Pick's Disease

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 22GTR, 43NINDS, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
frontotemporal dementia:
Inheritance: Autosomal dominant; Prevalence: 1-9/100000; Age of onset: Adulthood


Aliases & Descriptions:

pick's disease 8 42 43
pick disease 9 22 46
pick disease of the brain 42 60
frontotemporal dementia 48 60
picks disease 10 44
dementia with lobar atrophy and neuronal cytoplasmic inclusions 42
frontotemporal degeneration 60
dementia in pick's disease 8
lobar atrophy of the brain 42
lobar atrophy of brain 8
pick disease of brain 8
ftd 48


External Ids:

Disease Ontology8 DOID:11870
NCIt39 C85008
ICD9CM27 331.11
MESH via Orphanet35 D057180
ICD10 via Orphanet26 G31.0
SNOMED-CT via Orphanet57 230270009
UMLS via Orphanet61 C0338451
ICD1025 F02.0

Related Diseases for Pick's Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pick's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 189)
idRelated DiseaseScoreTop Affiliating Genes
1niemann-pick disease31.9NPC2, NPC1
2amyotrophic lateral sclerosis31.4MAPT, APP, PSEN1, SNCA
3lateral sclerosis31.4MAPT, SNCA
4myopathy31.1APP
5aphasia31.1MAPT
6niemann–pick disease30.9NPC2, LCAT, M6PR, NPC1, PSAP, CHIT1
7acid sphingomyelinase deficiency30.9SMPD1
8brain disease30.7SNCA, PSEN1, MAPT, HCRT, APP
9lysosomal storage disease30.6M6PR
10vascular dementia30.4SNCA, APP, PSEN1, MAPT
11parkinson's disease30.4MAPT, SNCA
12progressive supranuclear palsy30.3MAPT
13frontotemporal dementia30.3PSEN1, MAPT
14dementia30.3NPC1, PSEN1, HCRT, MAPT, CHIT1, SNCA
15huntington's disease30.3PSEN1, HCRT, MAPT, APP, SNCA
16sphingolipidosis30.1PSAP, NPC1, ASAH2
17lewy body dementia30.1SNCA, MAPT
18prion disease30.1HCRT, PSEN1
19normal pressure hydrocephalus30.1MAPT, HCRT
20cadasil30.1ABCA1, MAPT, CHIT1, PSEN1
21hydrocephalus30.1MAPT
22tauopathy29.9MAPT, SNCA, APP, PSEN1, NPC1
23amyloidosis29.9APP, SNCA, MAPT, PSEN1
24schizophrenia29.9APOD, PSEN1, SNCA, HCRT
25central nervous system disease29.9MAPT, APP, HCRT
26alzheimer's disease29.9SNCA, M6PR, APP, APOD, NPC1, SMPD1
27multiple system atrophy29.9MAPT, SNCA
28multiple sclerosis29.9HCRT, CHIT1
29motor neuron disease10.8
30inclusion body myopathy with early-onset paget disease and frontotemporal dementia10.8
31grn-related frontotemporal dementia10.7
32frontotemporal dementia with parkinsonism-1710.6
33liver disease10.6
34niemann-pick disease type c110.6
35amyotrophic lateral sclerosis with frontotemporal dementia10.6
36chmp2b-related frontotemporal dementia10.6
37frontotemporal dementia, chromosome 3-linked10.5
38niemann-pick disease type d10.5
39skin disease10.5
40inclusion body myopathy with paget disease of bone and/or frontotemporal dementia10.5
41neurologic diseases10.4
42neuronitis10.4
43niemann-pick disease type c210.4
44intracranial hypotension10.4
45paget's disease of bone10.4
46frontotemporal dementia, ubiquitin-positive10.4
47inclusion body myopathy with early-onset paget disease and frontotemporal dementia 110.4
48amyotrophic lateral sclerosis 14, with or without frontotemporal dementia10.4
49hepatitis10.4
50histiocytosis10.4

Graphical network of the top 20 diseases related to Pick's Disease:



Diseases related to pick's disease

Clinical Features for Pick's Disease

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46OMIM
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Clinical features from OMIM:

172700,600274,600795,607485

Clinical synopsis from OMIM:

172700

Drugs & Therapeutics for Pick's Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pick's Disease

Drug clinical trials:

Search ClinicalTrials for Pick's Disease

Search NIH Clinical Center for Pick's Disease

Search CenterWatch for Pick's Disease

Genetic Tests for Pick's Disease

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Sources:
22GTR
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Genetic tests related to Pick's Disease:

id Genetic test Affiliating Genes
1 Pick's Disease22

Anatomical Context for Pick's Disease

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Sources:
32MalaCards
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MalaCards organs/tissues related to Pick's Disease:

32
Brain, Cortex, Liver, Lung, Spleen, Temporal lobe, Olfactory bulb, Amygdala

Animal Models for Pick's Disease or affiliated genes

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36MGI
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Publications for Pick's Disease

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50PubMed
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Articles related to Pick's Disease:

(show top 50)    (show all 276)
idTitleAuthorsYear
1
Caspase-cleaved TAR DNA-binding protein-43 in Pick's disease. (20411029)
2009
2
Pick's disease with Pick bodies: an unusual autopsy case showing degeneration of the pontine nucleus, dentate nucleus, Clarke's column, and lower motor neuron. (17319287)
2007
3
An individualized approach to treatment for alzheimer's disease, pick's disease, and other dementias. (17062555)
2006
4
Glial fibrillary acidic protein is a major target of glycoxidative and lipoxidative damage in Pick's disease. (16987245)
2006
5
Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease. (14991385)
2004
6
An N-terminal fragment of ProSAAS (a granin-like neuroendocrine peptide precursor) is associated with tau inclusions in Pick's disease. (12914799)
2003
7
A story of Pick's disease: a rare form of dementia. (12080867)
2002
8
Glycogen synthase kinase-3 is associated with neuronal and glial hyperphosphorylated tau deposits in Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration. (12410379)
2002
9
Distribution of basal ganglia lesions in generalized variant of Pick's disease: a clinicopathological study of four autopsy cases. (11699556)
2001
10
Phosphorylated c-MYC expression in Alzheimer disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration. (11679086)
2001
11
A multidisciplinary approach to Pick's disease and frontotemporal dementia. Conference proceedings. May 6-7, 1999. Philadelphia, Pennsylvania, USA. (11402141)
2001
12
Pick's disease associated with the novel Tau gene mutation K369I. (11601501)
2001
13
Pick's disease is associated with mutations in the tau gene. (11117542)
2000
14
Apolipoprotein E polymorphism in Pick's disease and in Huntington's disease. (10924769)
2000
15
Tau-positive glial inclusions in progressive supranuclear palsy, corticobasal degeneration and Pick's disease. (10517506)
1999
16
Presenilin-1 expression in Pick's disease. (10541872)
1999
17
Huntingtin protein colocalizes with lesions of neurodegenerative diseases: An investigation in Huntington's, Alzheimer's, and Pick's diseases. (9527890)
1998
18
The expression of creatine kinase isoenzymes in neocortex of patients with neurodegenerative disorders: Alzheimer's and Pick's disease. (9270056)
1997
19
Pick's disease with amyotrophic lateral sclerosis. (9415547)
1997
20
Specific pathological Tau protein variants characterize Pick's disease. (8786374)
1996
21
Pick's disease: hyperphosphorylated tau protein segregates to the somatoaxonal compartment. (8960316)
1996
22
Role of complement in the aetiology of Pick's disease? (8627348)
1996
23
Neuropathologic overlap of progressive supranuclear palsy, Pick's disease and corticobasal degeneration. (8558172)
1996
24
Parietal Pick's disease mimicking cortical-basal ganglionic degeneration. (8058145)
1994
25
Remote memory and lexical retrieval in a case of frontal Pick's disease. (8042932)
1994
26
Reversible intermittent rhythmic myoclonus with fluoxetine in presumed Pick's disease. (8041377)
1994
27
31P magnetic resonance spectroscopy in Alzheimer's and Pick's disease. (8450937)
1993
28
Sporadic Pick's disease in a 28-year-old woman. (8435700)
1993
29
A case of early-onset Pick's disease. (1429481)
1992
30
Parvalbumin-immunoreactive neurons in the cortex in Pick's disease. (1895150)
1991
31
Neocortical morphometry and cholinergic neurochemistry in Pick's disease. (3381880)
1988
32
Marked loss of cerebral galactolipids in Pick's disease. (3322183)
1987
33
Increased proteins in post-mortem brain in a case of Pick's disease and in Huntington's disease. (2935597)
1985
34
Fine structure of lipid storage in epithelial cells lining bile ducts in Niemann-Pick's disease. (6228729)
1983
35
Pick's disease of early onset with neurologic symptomatology, rapid course, and nigral-striatal degeneration. (6839575)
1983
36
Niemann Pick's disease (chronic visceral form). A case report. (1002242)
1976
37
Diagnosis of type A Niemann-Pick's disease by conjunctival biopsy. (1187200)
1975
38
Niemann-Pick's disease. Clinical, biochemical and ultrastructural findings in a case of the infantile form. (56432)
1975
39
Familial pre-senile dementia: the revelance of a histological diagnosis of Pick's disease. (4716064)
1973
40
An autopsied unusual case of Pick's disease. (5171905)
1971
41
Electron microscopic structure of the "inclusion bodies" in Pick's disease. (4178657)
1968
42
Presenile dementia, clinically of the Pick's disease variety, occurring in a mother and daughter. (6029993)
1967
43
Chronic constrictive pericarditis (Pick's disease). (13959790)
1962
44
A report on two new cases of Niemann Pick's disease. (13973318)
1962
45
Report of a case of carcinoma of the lung with metastasis to the brain, simulating Pick's disease. (13710782)
1961
46
The clinical differentiation of Pick's disease. (13621145)
1958
47
Pick's disease. (13039626)
1953
48
ALZHEIMER'S and Pick's disease. (13011942)
1953
49
PICK'S DISEASE (Mediastino-pericarditic Pseudo-cirrhosis of the Liver): A Case, with Pericardial Resection and Recovery. (20321086)
1938
50
PERICARDITIC PSEUDO-CIRRHOSIS OF THE LIVER, OR PICK'S DISEASE. (20774453)
1929

Genetic Variations for Pick's Disease

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Pick's Disease:

62
id Symbol AA change Variation ID SNP ID
1MAPTp.Lys574ThrVAR_010344
2MAPTp.Gly706ArgVAR_010352
3MAPTp.Ser637PheVAR_019665
4MAPTp.Lys686IleVAR_019668

Expression for genes affiliated with Pick's Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pick's Disease

Search GEO for disease gene expression data for Pick's Disease.

Pathways for genes affiliated with Pick's Disease

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Sources:
51QIAGEN, 29KEGG, 53Reactome, 37NCBI BioSystems Database, 4Cell Signaling Technology
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Pathways related to Pick's Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Cholesterol and Sphingolipids transport / Generic schema (normal and CF)
10.5NPC2, NPC1
210.4APP, MAPT, PSEN1
3
Hide members
10.4SMPD1, PSAP, ASAH2
4
Cholesterol and Sphingolipids transport / Distribution to the intracellular membrane compartments (normal and CF)
10.4RAB9A, NPC2, NPC1
510.4PSEN1, APP, SNCA, MAPT
6
Hide members
10.4NPC1L1, LCAT, ABCA1
710.4PSAP, NPC2, NPC1, M6PR, SMPD1

Compounds for genes affiliated with Pick's Disease

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44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Pick's Disease according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1thioflavin4410.9APP, SNCA, MAPT
2thioflavine s4410.9APP, SNCA, MAPT
3glucosylceramide44 2411.8SMPD1, ASAH2, CHIT1, PSAP, NPC2
4ganglioside4410.8SMPD1, PSAP, NPC2, NPC1, APP
54-hydroxynonenal44 2411.8LCAT, APP, PSEN1, SNCA, MAPT
6choline44 11 2412.8APP, PSEN1, PSAP, SNCA, MAPT, ABCA1
7sterol4410.8LCAT, NPC1, NPC2, NPC1L1, PSEN1, ABCA1
8methionine sulfoxide44 11 2412.8ABCA1, SNCA, APP
9lactacystin4410.8APP, PSEN1, SNCA, MAPT, ABCA1
10carbachol44 28 1112.8APP, PSEN1, SNCA, MAPT, HCRT
11valine4410.8APP, PSEN1, PSAP, SNCA, MAPT
12mannose 6-phosphate44 2411.8M6PR, NPC1, PSAP, RAB9A, SMPD1
13methionine4410.8LCAT, PSEN1, SNCA, MAPT, ABCA1, SMPD1
14sphingosine44 11 2412.8NPC2, PSAP, ASAH2, SMPD1
15formate4410.8APP, SNCA, MAPT
16sodium dodecylsulfate4410.8MAPT, SNCA, APP, LCAT
17phosphatidylcholine4410.8LCAT, NPC1, SNCA, ABCA1, SMPD1
18monensin4410.8SMPD1, ABCA1, M6PR
19phospholipid4410.8LCAT, APOD, PSAP, SNCA, ABCA1, SMPD1
20glycolipid4410.8PSAP, NPC2, NPC1
21tmao4410.7SNCA, MAPT
22testosterone44 59 11 2413.7LCAT, APP, APOD, PSAP, SNCA, MAPT
23cysteine4410.7M6PR, LCAT, APP, NPC1, PSEN1, PSAP
24ceramide4410.7SMPD1, ASAH2, ABCA1, PSAP
25arginine4410.7M6PR, APP, PSEN1, PSAP, SNCA, MAPT
26glucose4410.7APOD, PSEN1, PSAP, SNCA, MAPT, HCRT
27glutamine4410.7LCAT, APP, PSEN1, SNCA, MAPT
28glutamate4410.7LCAT, APP, PSEN1, SNCA, MAPT, HCRT
2924s-hydroxy-cholesterol4410.7ABCA1, APP
30alanine4410.7LCAT, CCL18, APP, PSEN1, SNCA, MAPT
31phosphatidylserine44 28 1112.7ABCA1, MAPT, SNCA, PSAP
32oligonucleotide4410.7APOD, PSEN1, PSAP, HCRT, ABCA1, SMPD1
33dihydroceramide44 2411.7SMPD1, ASAH2, NPC2
34u18666a4410.7APP, NPC1
35serine4410.7M6PR, LCAT, APP, PSEN1, PSAP, SNCA
36thioflavin t4410.7SNCA, APP
37fatty acid4410.7LCAT, APOD, SNCA, ABCA1, ASAH2
38tacrine44 1111.6MAPT, APP
39cholesterol44 28 11 2413.6RAB9A, ABCA1, HCRT, SNCA, PSAP, PSEN1
40lipid4410.6SMPD1, M6PR, LCAT, ASAH2, RAB9A, ABCA1
41atp44 2811.6NPC1, NPC1L1, PSAP, HCRT, ABCA1, SMPD1
42h2o24410.6APP, PSEN1, SNCA, MAPT, SMPD1
43nmda44 2811.6APP, PSEN1, MAPT, HCRT
44donepezil44 11 2412.6MAPT, APP
45norepinephrine44 11 2412.5APP, PSEN1, SNCA, HCRT
46glycogen44 2411.4MAPT, SNCA, PSEN1, M6PR
47acetylcholine44 49 28 11 2414.4HCRT, MAPT, SNCA, APP
48alpha tocopherol4410.3LCAT, SNCA, ABCA1
49memantine44 28 1112.1MAPT, APP

GO Terms for genes affiliated with Pick's Disease

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16Gene Ontology
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Cellular components related to Pick's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1rough endoplasmic reticulumGO:00579110.6HCRT, SNCA, PSEN1
2perinuclear region of cytoplasmGO:04847110.6APP, APOD, NPC1, PSEN1, SNCA, HCRT
3axonGO:03042410.6APP, PSEN1, SNCA, MAPT
4extracellular regionGO:00557610.5HCRT, LCAT, APP, APOD, NPB, NPC1
5Golgi apparatusGO:00579410.5APP, NPC1, PSEN1, PSAP, SNCA, ABCA1
6lysosomeGO:00576410.5NPC1, NPC2, CHIT1, RAB9A
7growth coneGO:03042610.4MAPT, SNCA, PSEN1
8ciliary rootletGO:03525310.3PSEN1, APP
9extracellular spaceGO:00561510.3LCAT, CCL18, APOD, PSAP, CHIT1, SMPD1
10lysosomal membraneGO:00576510.1M6PR, NPC1, PSEN1, PSAP

Biological processes related to Pick's Disease according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1cholesterol transportGO:03030110.7NPC1L1, NPC2, NPC1, LCAT
2cholesterol effluxGO:03334410.7ABCA1, NPC2, NPC1
3cholesterol homeostasisGO:04263210.7LCAT, NPC1, NPC2, NPC1L1, ABCA1
4smooth endoplasmic reticulum calcium ion homeostasisGO:05156310.6PSEN1, APP
5cholesterol metabolic processGO:00820310.6LCAT, APP, NPC1, NPC2, ABCA1
6response to drugGO:04249310.6APOD, NPC1, NPC1L1, SNCA, SMPD1
7lipoprotein metabolic processGO:04215710.6LCAT, NPC1L1, ABCA1
8glycosphingolipid metabolic processGO:00668710.6SMPD1, ASAH2, PSAP
9intracellular cholesterol transportGO:03236710.6NPC2, ABCA1
10negative regulation of platelet-derived growth factor receptor signaling pathwayGO:01064210.5SNCA, APOD
11positive regulation of receptor recyclingGO:00192110.4SNCA, PSEN1
12reverse cholesterol transportGO:04369110.4ABCA1, LCAT
13sphingolipid metabolic processGO:00666510.3PSAP, ASAH2, SMPD1
14axon cargo transportGO:00808810.1MAPT, APP

Molecular functions related to Pick's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholesterol bindingGO:01548510.5ABCA1, NPC2, NPC1, APOD
2apolipoprotein bindingGO:03418510.4ABCA1, MAPT
3apolipoprotein A-I bindingGO:03418610.3ABCA1, LCAT
4protein bindingGO:00551510.2NPC1, NPB, APOD, APP, CCL18, LCAT
5hedgehog receptor activityGO:00815810.1NPC1L1, NPC1

Products for genes affiliated with Pick's Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pick's Disease

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet