Pick's Disease malady

NINDS: Frontotemporal dementia (FTD) describes a clinical syndrome associated with shrinking of the frontal and temporal anterior lobes of the brain. Originally known as Pick?s disease, the name and classification of FTD has been a topic of discussion for over a century.³¹

MalaCards: Pick's Disease, also known as pick disease of the brain, is related to vascular dementia and niemann–pick disease. An important gene associated with Pick's Disease is NPC2 (Niemann-Pick disease, type C2), and among its related pathways are Sphingolipid metabolism and Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction). The drugs citalopram hydrobromide and citalopram and the compounds glycolipid and glucose have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and cortex, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

OMIM: 172700

Aliases & Descriptions:

pick's disease 6 30 31 pick disease of the brain 30 43 picks disease 8 32 pick disease 7 33 dementia with lobar atrophy and neuronal cytoplasmic inclusions 30 dementia in pick's disease (disorder) 6

frontotemporal degeneration 43 lobar atrophy of the brain 30 pick's disease (disorder) 6 lobar atrophy of brain 6 pick disease of brain 6 dementia 43

Diseases related to pick's disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 473)

id	Related Disease	Score	Top Affiliating Genes
1	vascular dementia	36.6	BDNF, CHAT, APOE, APP, MBP, MAPT
2	niemann–pick disease	35.5	CHIT1, LCAT, ASAH2, M6PR, SMPD1, PSAP
3	alzheimer's disease	35.1	CLU, APOE, APP, MAPT, PSEN1
4	niemann-pick disease type c1	35.0	ASAH2, APOD, APP, MAPT, SNCA, SMPD1
5	acid sphingomyelinase deficiency	34.3	CNP, UGT8, MPZ, MBP, MAG, CCL3
6	lewy body dementia	34.1	PARK7, APOE, APP, MAPT, MAOB, SNCA
7	progressive supranuclear palsy	33.6	PARK7, CHAT, APOE, APP, MAPT, SNCA
8	tauopathy	33.1	PARK7, GRN, APP, MAPT, HTT, SNCA
9	cadasil	32.7	APOE, APP, MBP, CASP3, NOTCH1, RPS27A
10	inclusion body myopathy	32.7	APP, SNCA, RPS27A, TARDBP, PSEN1
11	binswanger's disease	32.0	APOE, APP, ACHE
12	immunodeficiency	31.8	MPZ, MBP, MAPT, MAG, HSPA5, PTS
13	cerebrovascular disease	31.5	APOE, APP, MBP, MAPT, PLP1, ACHE
14	amyotrophic lateral sclerosis with frontotemporal dementia	31.3	GRN, RPS27A, TARDBP
15	cerebral amyloid angiopathy	30.8	APOE, APP, MBP, MAPT, RPS27A, ABCA1
16	frontotemporal dementia	30.5	PCSK1N, BDNF, SCG2, CHGA, MTA2, GRN
17	primary progressive aphasia	30.3	GRN, MAPT, RPS27A
18	aphasia	30.3	GRN, APOE, APP, MAPT, SNCA, RPS27A
19	corticobasal degeneration	30.2	MYC, MAPT, MAPK3, MAPK1, CASP3, HRAS
20	semantic dementia	30.2	GRN, APOE, MAPT, RPS27A, TARDBP
21	alcoholism	30.2	MAPT, MAOA, MAOB, HNMT, SNCA, TSPO
22	parkinson's disease	30.1	PARK7, UCHL1, MAPT, SNCA, GBA
23	amyloidosis	29.7	CLU, CHIT1, LCAT, APOE, APP, MAPT
24	sphingolipidosis	29.5	ASAH2, PSAP, NPC1, GBA
25	lysosomal storage disease	29.2	NAGA, CHIT1, M6PR, SMPD1, HEXA, PSAP
26	creutzfeldt-jakob syndrome	29.2	APOE, APP, MAPT, SNCA, CRYAB, RPS27A
27	gaucher's disease	29.1	CHIT1, UGCG, ASAH2, CCL18, SNCA, SMPD1
28	gliosis	29.0	CHAT, MPZ, APP, MBP, MAPT, MAOB
29	early-onset familial alzheimer disease	28.9	APP, MAPT, SNCA, PSEN1
30	familial idiopathic basal ganglia calcification	28.9	APP, MAPT, PSEN1
31	supranuclear palsy	28.9	RD3, MYC, PARK7, CHAT, MTA2, APOE
32	prion disease	28.8	CLU, APP, MAPT, PSEN1
33	basal ganglia calcification	28.8	APP, MAPT, PSEN1
34	alzheimer disease type 2	28.8	APOE, APP, MAPT, PSEN1
35	type 2 diabetes mellitus	28.7	LCAT, APOE, HRAS, DYT10, PTS, ABCA1
36	tremor	28.6	PARK7, UCHL1, MPZ, HNMT, PTS, SNCA
37	peripheral neuropathy	28.6	BDNF, MPZ, APOE, MAG, PLP1, HEXA
38	huntington's disease	28.4	BDNF, CHAT, UCHL1, APP, MAPT, MAOB
39	motor neuron disease	28.3	BDNF, CHAT, UCHL1, GRN, APOE, MAPT
40	myopathy	28.2	CLU, BDNF, CHAT, CHKB, MPZ, CD59
41	twinning	28.1	BDNF, CKB, CHGA, APOE, MBP, MAOA
42	amyotrophic lateral sclerosis	28.1	PCSK1N, PARK7, BDNF, SCG2, CHAT, CHGA
43	multiple system atrophy	28.1	PARK7, BDNF, CHAT, UCHL1, APOE, MBP
44	head injury	28.0	BDNF, CKB, CHAT, APOE, APP, MBP
45	lateral sclerosis	28.0	PCSK1N, PARK7, BDNF, SCG2, CHAT, CHGA
46	down syndrome	28.0	CNP, CLU, BDNF, CHAT, APOE, APP
47	spasticity	27.9	MYC, MPZ, MBP, MAPT, CCL3, HTT
48	chorea	27.9	BDNF, HTT, RPS27A, ACHE, TARDBP, SYP
49	hydrocephalus	27.6	BDNF, APOE, APP, MBP, MAPT, CASP3
50	hereditary cerebral hemorrhage with amyloidosis	27.2	APP, RPS27A, SYP, PSEN1

Clinical features from OMIM: 172700

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 citalopram, citalopram hydrobromide, prochlorperazine, prochlorperazine edisylate, prochlorperazine maleate, risperidone

MalaCards organs/tissues related to pick's disease:

²²

MGI Mouse Phenotypes related to pick's disease:

²⁵ (show all 25)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.2	ADAMTS1, PSEN1, PSAP, PTS, HTT, CNP
2	hematopoietic system phenotype	MP:0005397	9.9	SQSTM1, NOTCH1, GRN, ATF2, MTA2, UCHL1
3	liver/biliary system phenotype	MP:0005370	9.7	PSAP, SQSTM1, NPC1, NPC1L1, NPC2, GBA
4	respiratory system phenotype	MP:0005388	9.7	PSEN1, NPC1, ADORA1, GBA, HCRT, ACHE
5	immune system phenotype	MP:0005387	9.3	PLP1, ABCA1, TLR4, PSAP, PSEN1, SQSTM1
6	adipose tissue phenotype	MP:0005375	8.8	TARDBP, SQSTM1, NPC1, ADAMTS1, TLR4, ACHE
7	craniofacial phenotype	MP:0005382	8.8	PSEN1, HEXA, ACHE, NOTCH1, CRYAB, DYRK1A
8	taste/olfaction phenotype	MP:0005394	8.6	SNCA, CASP3, HTT, MAPK1, MAPT, BDNF
9	no phenotypic analysis	MP:0003012	8.5	HSP90B1, HRAS, SNCA, ACHE, TARDBP, HTT
10	hearing/vestibular/ear phenotype	MP:0005377	8.5	NOTCH1, ACHE, HEXA, TLR4, PSAP, CASP3
11	digestive/alimentary phenotype	MP:0005381	8.3	CRYAB, NOTCH1, ABCA1, TLR4, PSAP, PSEN1
12	vision/eye phenotype	MP:0005391	8.2	PLP1, NOTCH1, ACHE, HEXA, TLR4, PSAP
13	muscle phenotype	MP:0005369	7.9	PTS, CRYAB, NOTCH1, ABCA1, ACHE, HCRT
14	skeleton phenotype	MP:0005390	7.8	M6PR, SNCA, CRYAB, NOTCH1, HEXA, PSAP
15	integument phenotype	MP:0010771	7.8	SNCA, NOTCH1, TLR4, PSEN1, SQSTM1, NPB
16	normal phenotype	MP:0002873	7.7	HRAS, SMPD2, NOTCH1, SYP, PSAP, PSEN1
17	renal/urinary system phenotype	MP:0005367	7.6	HMOX1, M6PR, SNCA, NOTCH1, ABCA1, HEXA
18	reproductive system phenotype	MP:0005389	6.9	ADAMTS5, APP, GRN, GRM1, CD59, MPZ
19	nervous system phenotype	MP:0003631	5.6	GBA, NEFL, NPC2, NPC1, MAPK3, MAOA
20	cardiovascular system phenotype	MP:0005385	5.5	HRAS, HMOX1, DYRK1A, PTS, SNCA, NOTCH1
21	mortality/aging	MP:0010768	5.4	UCHL1, UGT8, UGCG, CHAT, BDNF, CNP
22	cellular phenotype	MP:0005384	4.8	NOTCH1, PLP1, SMPD1, SNCA, TUBB3, M6PR
23	growth/size phenotype	MP:0005378	4.0	NOTCH1, PLP1, PLCB1, CRYAB, SMPD1, SNCA
24	homeostasis/metabolism phenotype	MP:0005376	3.6	HSPA5, MTA2, LCAT, UGT8, UGCG, CHKB
25	behavior/neurological phenotype	MP:0005386	3.3	GBA, ADAMTS5, ADORA1, NEFM, NEFH, NPC2

Articles related to pick's disease:

(show top 50)    (show all 154)

id	Title	Authors	Year	Affiliating Genes
1	Identification and characterization of eight novel SM PD1 mutations causing types A and B Niemann-Pick disease. (20386867)	Desnick J.P.... Schuchman E.H.	2010	SMPD1
2	A novel missense mutation of the SMPD1 gene in a Taiwanese patient with type B Niemann-Pick disease. (19050888)	Lan M.Y.... Liu Y.F.	2009	SMPD1
3	Prenatal revelation of Niemann-Pick disease type C in siblings. (18554276)	Moreno R.... LaquerriA"re A.	2008	NPC1
4	Characterization of common SMPD1 mutations causing types A and B Niemann-Pick disease and generation of mutation-specific mouse models. (18815062)	Jones I.... Schuchman E.H.	2008	SMPD1
5	Stem cells in Niemann-Pick disease. (18525117)	Kim S.J.... Kang K.S.	2008	NPC1
6	Up-regulation of adenosine A1 receptors in frontal cortex from Pick's disease cases. (18052973)	Albasanz J.L.... Martin M.	2007	ADORA1
7	The pathogenesis and treatment of acid sphingomyelinase-deficient Niemann-Pick disease. (17632693)	Schuchman E.H.	2007	SMPD1
8	Treatment of Niemann-Pick disease type C in two child ren with miglustat: initial responses and maintenance of effects over 1 year. (17603755)	Chien Y.H.... Hwu W.L.	2007	UGCG
9	Abnormal alpha-synuclein solubility, aggregation and nitration in the frontal cortex in Pick's disease. (16516382)	Dalfo E.... Ferrer I.	2006	SNCA
10	Critical assessment of chitotriosidase analysis in the rational laboratory diagnosis of children with Gaucher disease and Niemann-Pick disease type A/B and C. (16972172)	Ries M.... Mengel E.	2006	CHIT1
11	Identification of novel biomarkers for Niemann-Pick disease using gene expression analysis of acid sphingomyelinase knockout mice. (16214420)	Dhami R.... Schuchman E.H.	2006	SMPD1
12	Mutations in NPC1 in two Brazilian patients with Niemann-Pick disease type C and progressive supranuclear palsy-like presentation. (17044092)	Godeiro-JA_nior C.... Barsottini O.	2006	NPC1
13	Metalloproteinase ADAMTS-1 but not ADAMTS-5 is manifold overexpressed in neurodegenerative disorders as Down syndrome, Alzheimer's and Pick's disease. (15661359)	Miguel R.F.... Lubec G.	2005	ADAMTS1, ADAMTS5
14	Increased NPC1 mRNA in skin fibroblasts from Niemann-Pick disease type C patients. (15130691)	Yamamoto T.... Ohno K.	2004	NPC1
15	Synaptophysin immunoreactivity in Pick's disease: comparison with Alzheimer's disease and dementia with Lewy bodies. (15633942)	Lippa C.F.	2004	SYP
16	Clinicopathological study of two subtypes of Pick's disease in Japan. (12457075)	Odawara T.... Kosaka K.	2003	RPS27A
17	Sleep disturbances and hypocretin deficiency in Niemann-Pick disease type C. (12841368)	Vankova J.... Nevsimalova S.	2003	HCRT
18	An N-terminal fragment of ProSAAS (a granin-like neuroendocrine peptide precursor) is associated with tau inclusions in Pick's disease. (12914799)	Kikuchi K.... Kato T.	2003	PCSK1N
19	Analysis of tau haplotypes in Pick's disease. (12177383)	Morris H.R.... Hutton M.	2002	MAPT
20	Bone marrow manifestation of Niemann-Pick disease. A review of histiocytic proliferations of the bone marrow (12436303)	Kvasnicka H.M.... Thiele J.	2002	SMPD1
21	Human brain cytosolic histamine-N-methyltransferase is decreased in Down syndrome and increased in Pick's disease. (11880199)	Kim S.H.... Lubec G.	2002	HNMT
22	Phosphorylated c-MYC expression in Alzheimer disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration. (11679086)	Ferrer I.... Puig B.	2001	MYC, CASP3
23	The extended haplotype of the microtubule associated protein tau gene is not associated with Pick's disease. (11166961)	Russ C.... Powell J.F.	2001	MAPT
24	Critical role for glycosphingolipids in Niemann-Pick disease type C. (11525744)	Zervas M.... Walkley S.U.	2001	NPC1, UGCG, NPC2
25	Niemann-Pick Disease versus acid sphingomyelinase def iciency. (11313707)	Lozano J.... Kolesnick R.	2001	SMPD1
26	Permeability barrier disorder in Niemann-Pick disease: sphingomyelin-ceramide processing required for normal barrier homeostasis. (10951284)	Schmuth M.... Holleran W.M.	2000	SMPD1
27	Progress in hereditary tauopathies: a mutation in the Tau gene (G389R) causes a Pick disease-like syndrome. (11193177)	Ghetti B.... Goedert M.	2000	MAPT
28	Genotype-phenotype relationship of Niemann-Pick disease type C: a possible correlation between clinical onset and levels of NPC1 protein in isolated skin fibroblasts. (11182931)	Yamamoto T.... Ohno K.	2000	NPC1
29	Hematopoietic stem cell gene therapy leads to marked visceral organ improvements and a delayed onset of neurological abnormalities in the acid sphingomyelinase deficient mouse model of Niemann-Pick disease. (11083499)	Miranda S.R.... Schuchman E.H.	2000	SMPD1
30	Pick's disease: selective occurrence of apolipoprotein E-immunoreactive Pick bodies in the limbic system. (9452816)	Hayashi S.... Takahashi H.	1998	APOE
31	Niemann Pick Disease type A in Israeli Arabs: 677delT , a common novel single mutation. Mutations in brief no. 161. Online. (10694919)	Gluck I.... Bach G.	1998	SMPD1
32	Cellular cholesterol storage in the Niemann-Pick disease type C mouse is associated with increased expression and defective processing of apolipoprotein D. (9422368)	Suresh S.... Patel S.C.	1998	APOD
33	Phenotypic and genetic heterogeneity in Niemann-Pick disease type C: current knowledge and practical implications. (9060145)	Vanier M.T.	1997	SMPD1
34	Linkage of Niemann-Pick disease type D to the same region of human chromosome 18 as Niemann-Pick disease type C. (9245994)	Greer W.L.... Neumann P.E.	1997	NPC1
35	Niemann-Pick disease: mutation update, genotype/phenotype correlations, and prospects for genetic testing. (10464620)	Schuchman E.H.... Miranda S.R.	1997	SMPD1
36	Hyperphosphorylated tau proteins differentiate corticobasal degeneration and Pick's disease. (8928611)	BuAce Scherrer V.... Delacourte A.	1996	MAPT
37	Specific pathological Tau protein variants characterize Pick's disease. (8786374)	Delacourte A.... Gauvreau D.	1996	MAPT
38	Cytoskeletal pathology in non-Alzheimer degenerative dementia: new lesions in diffuse Lewy body disease, Pick's disease, and corticobasal degeneration. (8841955)	Dickson D.W.... Davies P.	1996	MAPT, RPS27A
39	Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease. (7670466)	Horinouchi K.... Schuchman E.H.	1995	SMPD1
40	Two new mutations in the acid sphingomyelinase gene causing type A Niemann-pick disease: N389T and R441X. (8680412)	Schuchman E.H.	1995	SMPD1
41	Expression of the complement membrane attack complex and its inhibitors in Pick disease brain. (7525023)	Yasuhara O.... McGeer P.L.	1994	CLU, CD59
42	Severe panencephalic Pick's disease with Alzheimer's disease-like neuropil threads and synaptophysin immunoreactivity. (7847079)	Cochran E.J.... Mufson E.J.	1994	SYP
43	Accumulation of amyloid precursor protein in brain lesions of patients with Pick disease. (8084502)	Yasuhara O.... McGeer P.L.	1994	APP
44	Linkage of Niemann-Pick disease type C to human chromosome 18. (8446622)	Carstea E.D.... Vanier M.T.	1993	NPC1
45	Identification and expression of a common missense mutation (L302P) in the acid sphingomyelinase gene of Ashkenazi Jewish type A Niemann- Pick disease patients. (1391960)	Levran O.... Schuchman E.H.	1992	SMPD1
46	Identification and expression of five mutations in the human acid sphingomyelinase gene causing types A and B Niemann-Pick disease. Molecular evidence for genetic heterogeneity in the neuronopathic and non-neuronopathic forms. (1618760)	Takahashi T.... Schuchman E.H.	1992	SMPD1
47	Niemann-Pick disease: a frequent missense mutation in the acid sphingomyelinase gene of Ashkenazi Jewish type A and B patients. (2023926)	Levran O.... Schuchman E.H.	1991	SMPD1
48	Molecular basis of acid sphingomyelinase deficiency in a patient with Niemann-Pick disease type A. (1718266)	Ferlinz K.... Sandhoff K.	1991	SMPD1
49	A high ratio of chromogranin A to synaptin/synaptophysin is a common feature of brains in Alzheimer and Pick disease. (2110534)	Weiler R.... Winkler H.	1990	CHGA, SCG2
50	Niemann-Pick disease, Type C: evidence for the deficiency of an activating factor stimulating sphingomyelin and glucocerebroside degradation. (6256275)	Christomanou H.	1980	PSAP

Genes related to pick's disease according to GeneCards:

(show top 50)    (show all 89)

id	Symbol	Description	Score	GeneCards Section Context
1	NPC2	Niemann-Pick disease, type C2	11.1	Aliases & Descriptions, Orthologs, Summaries, Publications (show all 5 sections) Transcripts
2	SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	11.1	Summaries, Orthologs, Publications
3	NPC1	Niemann-Pick disease, type C1	11.1	Orthologs, Publications, Transcripts, Aliases & Descriptions
4	MAPT	microtubule-associated protein tau	11.1	Summaries, Publications
5	NPC1L1	NPC1 (Niemann-Pick disease, type C1, gene)-like 1	11.1	Aliases & Descriptions, Publications, Transcripts, Orthologs
6	ASAH2	N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2	11.0
7	PSAP	prosaposin	11.0	Publications
8	SNCA	synuclein, alpha (non A4 component of amyloid precursor)	11.0	Publications
9	APP	amyloid beta (A4) precursor protein	11.0	Publications
10	M6PR	mannose-6-phosphate receptor (cation dependent)	11.0	Publications
11	CHIT1	chitinase 1 (chitotriosidase)	11.0	Publications
12	APOD	apolipoprotein D	11.0	Publications
13	HCRT	hypocretin (orexin) neuropeptide precursor	11.0	Publications
14	LCAT	lecithin-cholesterol acyltransferase	11.0
15	PSEN1	presenilin 1	11.0	Publications
16	ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	11.0
17	NPB	neuropeptide B	11.0
18	SMPD2	sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)	11.0
19	NAGA	N-acetylgalactosaminidase, alpha-	11.0	Publications
20	CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	11.0	Publications
21	CNP	2',3'-cyclic nucleotide 3' phosphodiesterase	11.0	Publications
22	UGT8	UDP glycosyltransferase 8	11.0	Publications
23	MAG	myelin associated glycoprotein	11.0	Publications
24	CES1	carboxylesterase 1	11.0	Publications
25	MPZ	myelin protein zero	11.0	Publications
26	TUBB3	tubulin, beta 3 class III	11.0	Publications
27	UGCG	UDP-glucose ceramide glucosyltransferase	11.0	Publications
28	PLP1	proteolipid protein 1	11.0	Publications
29	PTS	6-pyruvoyltetrahydropterin synthase	11.0	Publications
30	CRYAB	crystallin, alpha B	11.0	Publications
31	ATF2	activating transcription factor 2	11.0	Publications
32	RPS27A	ribosomal protein S27a	11.0	Publications
33	CLU	clusterin	11.0	Publications
34	GBA	glucosidase, beta, acid	11.0	Publications
35	CHAT	choline O-acetyltransferase	11.0	Publications
36	CD59	CD59 molecule, complement regulatory protein	11.0	Publications
37	TARDBP	TAR DNA binding protein	11.0	Publications
38	CCL3	chemokine (C-C motif) ligand 3	11.0	Publications
39	CHGA	chromogranin A (parathyroid secretory protein 1)	11.0	Publications
40	CHKB	choline kinase beta	11.0	Publications
41	IGF2R	insulin-like growth factor 2 receptor	11.0	Publications
42	SQSTM1	sequestosome 1	11.0
43	ACHE	acetylcholinesterase	11.0	Publications
44	HTT	huntingtin	11.0	Publications
45	TLR4	toll-like receptor 4	11.0	Publications
46	MBP	myelin basic protein	11.0	Publications
47	APOE	apolipoprotein E	11.0	Publications
48	LOC643387	TAR DNA binding protein pseudogene	11.0	Publications
49	PCSK1N	proprotein convertase subtilisin/kexin type 1 inhibitor	11.0	Proteins, Publications
50	KPRP	keratinocyte proline-rich protein	11.0	Orthologs

Pathways related to pick's disease according to GeneDecks:

(show all 46)

id	Pathway	Score	Top Affiliating Genes
1	Sphingolipid metabolism20	10.7	GBA, SMPD2, SMPD1, ASAH2, UGT8, UGCG
2	Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction)34	10.6	ACHE, CHGA, CHAT
3	Cholesterol and Sphingolipids transport / Distribution to the intracellular membrane compartments (normal and CF)41	10.5	NPC2, NPC1, TSPO, RAB9A
4	Lysosome20	10.5	GBA, NPC2, NPC1, PSAP, HEXA, SMPD1
5	Metabolism of lipids and lipoproteins38	10.4	SMPD2, ACHE, PSAP, NPC1L1, GBA, SMPD1
6	Alzheimers Disease Pathway36	9.9	PSEN1, MAPK1, MAPT, APP, APOE
7	Ceramide Pathway36	9.3	SMPD1, HRAS, CASP3, MAPK3, ATF2
8	Development_EGFR signaling via small GTPases41	9.2	HRAS, MAPK1, MYC
9	UVC-Induced MAPK Signaling36	9.1	SMPD2, SMPD1, HRAS, MAPK1, MAPK3
10	MIF Action Through Endocytic Pathway36	9.1	TLR4, MAPK1, MAPK3
11	Nur77-Induced AICD in Macrophage36	9.1	TLR4, HRAS, MAPK1, MAPK3
12	G-protein signaling_Ras family GTPases in kinase cascades (scheme)41	9.1	HRAS, MAPK1, MAPK3, ATF2
13	G-protein signaling Ras family GTPases in kinase cascades (scheme)10	9.1	HRAS, MAPK1, MAPK3, ATF2
14	PI3K Signaling in B-Lymphocyte36	9.0	PLCB1, MAPK1, MAPK3, ATF2
15	Neuroscience3	9.0	CNP, NEFM, NEFL, NEFH, PSEN1, SYP
16	UVA-Induced MAPK Signaling36	8.9	PLCB1, SMPD2, HRAS, CASP3, MAPK1
17	Development_EPO-induced Jak-STAT pathway41	8.9	MYC, MAPK3, MAPK1
18	Prion diseases20	8.8	NOTCH1, HSPA5, MAPK1, MAPK3
19	Pathway_PA16598005034	8.8	HRAS, MAPK1, MAPK3, MYC
20	NGF Pathway36	8.8	SMPD2, HRAS, MAPK1, MAPK3, MYC
21	CCKBR-Gastrin Stimulated Signaling36	8.8	PLCB1, HRAS, MAPK1, MAPK3, ATF2
22	Thyroid cancer20	8.8	MYC, MAPK3, MAPK1, HRAS
23	Development Angiotensin signaling via PYK210	8.8	PLCB1, HRAS, MAPK1, MAPK3, ATF2
24	Development_Angiotensin signaling via PYK241	8.7	PLCB1, HRAS, MAPK1, MAPK3, ATF2
25	Immune response_IL-2 activation and signaling pathway41	8.7	HRAS, MAPK1, MAPK3, ATF2, MYC
26	Immune response IL-2 activation and signaling pathway10	8.7	HRAS, MAPK1, MAPK3, ATF2, MYC
27	Development_A1 receptor signaling41	8.7	ADORA1, HRAS, MAPK1, MAPK3, ATF2
28	LPS Stimulated MAPK Signaling36	8.7	TLR4, PLCB1, HRAS, MAPK1, MAPK3, ATF2
29	Development A1 receptor signaling10	8.7	ADORA1, HRAS, MAPK1, MAPK3, ATF2
30	Immune response IL-3 activation and signaling pathway10	8.7	HRAS, MAPK1, MAPK3, ATF2
31	Cholinergic synapse20	8.7	ACHE, PLCB1, HRAS, MAPK1, MAPK3, CHAT
32	Development EPO-induced Jak-STAT pathway10	8.6	HRAS, MAPK1, MAPK3, MYC
33	S-1P Stimulated Signaling36	8.6	PLCB1, SMPD2, SMPD1, CASP3, MAPK1, MAPK3
34	Development EGFR signaling via small GTPases10	8.5	HRAS, MAPK1, MAPK3, MYC
35	Alzheimers disease20	8.4	PSEN1, PLCB1, SNCA, CASP3, MAPK1, MAPK3
36	Apoptosis and survival_Role of CDK5 in neuronal death and survival41	8.4	HRAS, CASP3, MAPK1, MAPK3
37	Immune response_IL-3 activation and signaling pathway41	8.4	MAPK1, MAPK3, ATF2, HRAS
38	Gap junction20	8.4	PLCB1, TUBB3, HRAS, MAPK1, MAPK3, GRM1
39	Long-term depression20	8.3	MAPK3, MAPK1, HRAS, PLCB1, GRM1
40	Long-term potentiation20	8.3	PLCB1, HRAS, MAPK1, MAPK3, GRM1
41	TRKA Signaling36	8.2	HRAS, CASP3, MAPK1, MAPK3, MYC
42	PEDF Induced Signaling36	8.2	HRAS, CCL18, CCL3, MAPK1, MAPK3, BDNF
43	Signaling in Gap Junctions36	7.9	PLCB1, TUBB3, HRAS, MAPK1, MAPK3, GRM1
44	Endothelin-1 Signaling Pathway36	7.9	PLCB1, HRAS, CASP3, CCL18, CCL3, MAPK1
45	MAPK signaling pathway20	7.7	HRAS, CASP3, MAPK1, MAPK3, MAPT, ATF2
46	Molecular Mechanisms of Cancer36	7.1	TUBB3, PLCB1, NOTCH1, PSEN1, HRAS, CASP3

Compounds related to pick's disease according to GeneDecks:

(show top 50)    (show all 242)

id	Compound	Score	Top Affiliating Genes
1	glycolipid32	10.3	GBA, NPC1, PSAP, TLR4, HEXA, MAG
2	glucose32	10.1	GRN, ATF2, CKB, SCG2, NAGA, HSP90B1
3	ganglioside32	10.1	SMPD1, NPC2, NPC1, PSAP, SYP, HEXA
4	carbachol32 9 9	12.0	SNCA, GRM1, HCRT, ADORA1
5	n acetylcysteine32	10.0	BDNF, CLU, APOE, MBP, TLR4, RPS27A
6	threonine32	9.8	DYRK1A, IGF2R, MAG, PTS, MAPT, PLCB1
7	choline32 9 18 9	12.4	CHAT, APP, ACHE, CHKB, BDNF, PSEN1
8	phospholipid32	9.3	GBA, PSAP, SYP, TLR4, ABCA1, PLP1
9	h2o232	9.0	PSEN1, SYP, TLR4, TSPO, RPS27A, CRYAB
10	cocaine32 9 9	11.0	TSPO, BDNF, CHAT, MBP, CHKB, CES1
11	glutamine32	8.9	PLP1, PSEN1, SYP, TSPO, RPS27A, CKB
12	methionine32	8.8	CHGA, LCAT, MPZ, MAPT, HSPA5, HSP90B1
13	kainate32	8.8	BDNF, CLU, TSPO, PICK1, CHAT, GRM1
14	phosphatidylcholine32	8.7	SNCA, NPC1, MBP, ABCA1, PLP1, CHAT
15	acetylcholine32 9 18 9	11.7	ADORA1, SYP, TLR4, HCRT, ACHE, RPS27A
16	aspartate32	8.6	CRYAB, SMPD1, HRAS, CCL3, MBP, APP
17	nitric oxide32 9 18 9	11.6	GBA, SYP, TLR4, HCRT, ABCA1, PLCB1
18	4-hydroxynonenal32 18	9.5	PSEN1, CHAT, MYC, LCAT, ATF2, RPS27A
19	simvastatin32 34 42 9 18 9	13.5	CASP3, CES1, TLR4, ABCA1, HMOX1, HRAS
20	6-hydroxydopamine32	8.5	MYC, RPS27A, PARK7, BDNF, CHAT, APP
21	alanine32	8.5	NEFM, TLR4, DYRK1A, HMOX1, HTT, CCL18
22	gaba32 42	9.4	APP, PLP1, TUBB3, HCRT, BDNF, CKB
23	testosterone32 9 18 9	11.3	PSAP, SYP, BDNF, APOD, PARK7, CLU
24	ceramide32	8.2	CASP3, ABCA1, TLR4, PSAP, GBA, SMPD2
25	glycogen32 18	9.2	NEFM, PSEN1, SYP, RPS27A, NOTCH1, SNCA
26	cyclosporin a32 42	9.1	HRAS, HMOX1, RPS27A, ABCA1, TSPO, TLR4
27	lactacystin32	8.1	MYC, APOE, APP, MAPT, MAPK1, RPS27A
28	arginine32	8.0	HSPA5, IGF2R, HRAS, HMOX1, PSEN1, PSAP
29	norepinephrine32 9 18 9	11.0	HMOX1, BDNF, SCG2, MAOB, MAPK3, MAOA
30	cysteine32	7.8	CHKB, HRAS, CASP3, HSPA5, HTT, IGF2R
31	dopamine32 9 18 9	10.7	TSPO, HCRT, ACHE, SNCA, PTS, HSPA5
32	superoxide32 18	8.7	CRYAB, SMPD2, SMPD1, HMOX1, HRAS, CASP3
33	lactate32	7.6	CHKB, TLR4, MAOB, MAPT, CD59, MBP
34	cholesterol32 9 18 9	10.4	HSPA5, HTT, IGF2R, CCL3, MAPK3, APP
35	atp32	7.2	NEFL, HSP90B1, HSPA5, HTT, MAPK3, CD59
36	lipid32	7.1	NPC2, MAG, MBP, APP, APOE, APOD
37	calcium32 9 18 9	10.0	MAPK1, MAPK3, GRM1, CD59, CHKB, CHAT
38	dexamethasone32 42 34 9 9	10.9	HCRT, SYP, MYC, CLU, TLR4, ADORA1
39	paclitaxel32 34 9 9	9.9	CHGA, UGCG, ATF2, APP, MAPT, MBP
40	glutamate32	6.9	TUBB3, LCAT, CHAT, CLU, CNP, MPZ
41	oxygen32 18	7.9	HSP90B1, PARK7, CLU, BDNF, CKB, HSPA5
42	forskolin32 42 9 9	9.8	ADAMTS1, MAPK3, CNP, BDNF, SCG2, CKB
43	cisplatin32 34 9 9	9.4	HMOX1, TUBB3, SMPD1, HNMT, CHGA, CASP3
44	nmda32 42	7.2	MAPK3, MAOA, MAPT, APP, APOE, GRM1
45	cycloheximide32	6.1	ABCA1, TLR4, PSEN1, NPC1, RPS27A, MAPK1
46	vegf32	5.5	DYT10, MAPK3, CCL3, CCL18, APP, APOE
47	retinoic acid32 42 18	7.5	TLR4, ABCA1, RPS27A, NOTCH1, PLP1, DYT10
48	estrogen32	5.0	MYC, MAPK3, MAOB, CCL3, IGF2R, MAPK1
49	tyrosine32	4.6	NEFH, GRM1, MBP, MAPK3, HRAS, HSPA5
50	serine32	3.5	GBA, ADORA1, ADAMTS1, NEFM, NEFH, SQSTM1

Cellular components related to pick's disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	neurofilament	GO:005883	10.2	NEFM, NEFL, NEFH
2	extracellular space	GO:005615	9.6	APOE, CCL3, CCL18, HMOX1, SMPD1, PSAP
3	perinuclear region of cytoplasm	GO:048471	9.4	SNCA, ACHE, HCRT, TLR4, NPC1, HRAS
4	extracellular region	GO:005576	9.2	SNCA, NOTCH1, ACHE, HCRT, PSAP, NPB
5	axon	GO:030424	9.1	MYC, NEFM, NEFL, NEFH, SNCA, TUBB3
6	endoplasmic reticulum	GO:005783	9.0	ADORA1, NPC2, NPC1, SQSTM1, PSEN1, HMOX1
7	late endosome	GO:005770	8.4	SQSTM1, HTT, MAPK1, MAPK3, RAB9A
8	Golgi apparatus	GO:005794	8.4	ABCA1, ACHE, PSAP, PSEN1, NPC1, CRYAB
9	mitochondrion	GO:005739	7.6	NEFH, PSEN1, PSAP, CRYAB, SNCA, PTS
10	cytosol	GO:005829	6.3	CASP3, HRAS, HMOX1, PTS, SNCA, CRYAB

Biological processes related to pick's disease according to GeneDecks:

(show all 38)

id	Name	GO ID	Score	Top Affiliating Genes
1	cholesterol transport	GO:030301	10.8	NPC2, NPC1L1, NPC1, LCAT
2	cholesterol homeostasis	GO:042632	10.7	NPC2, NPC1L1, NPC1, ABCA1, APOE, LCAT
3	cholesterol efflux	GO:033344	10.7	NPC2, NPC1, ABCA1, APOE
4	reverse cholesterol transport	GO:043691	10.6	ABCA1, APOE, LCAT, CLU
5	axon cargo transport	GO:008088	10.6	NEFM, HTT, MAPT, APP, UGT8
6	cholesterol metabolic process	GO:008203	10.6	NPC2, NPC1, ABCA1, APOE, LCAT
7	phosphatidylcholine biosynthetic process	GO:006656	10.5	ACHE, LCAT, CHKB, CHAT
8	glycosphingolipid metabolic process	GO:006687	10.5	GBA, PSAP, HEXA, SMPD2, SMPD1, ASAH2
9	sphingolipid metabolic process	GO:006665	10.5	GBA, PSAP, HEXA, SMPD2, SMPD1, ASAH2
10	adult walking behavior	GO:007628	10.5	NPC1, HEXA, MAPT, UCHL1, CHAT
11	activation of MAPKK activity	GO:000186	10.4	GRM1, PSEN1
12	negative regulation of MAP kinase activity	GO:043407	10.4	GBA, SMPD1, APOE, UCHL1
13	response to toxin	GO:009636	10.3	TLR4, CCL3, MAOB, MBP, CES1, CNP
14	phospholipid metabolic process	GO:006644	10.3	CHAT, GBA, PSAP, HEXA, ACHE, SMPD2
15	adult locomotory behavior	GO:008344	10.2	CNP, PARK7, APP, SNCA
16	positive regulation of protein dephosphorylation	GO:035307	10.2	GBA, ADORA1, SMPD1
17	lipoprotein metabolic process	GO:042157	10.2	NPC1L1, ABCA1, APOE, LCAT
18	neuron apoptotic process	GO:051402	10.1	PSEN1, CASP3, HTT, APP
19	regulation of synaptic plasticity	GO:048167	10.0	BDNF, HTT, PSEN1, ADORA1
20	induction of apoptosis by extracellular signals	GO:008624	9.8	ADORA1, SQSTM1, PSEN1, RPS27A, SMPD2, CASP3
21	cell death	GO:008219	9.7	GBA, NEFH, TARDBP, HEXA, PLP1, SMPD1
22	negative regulation of neuron apoptotic process	GO:043524	9.6	PSEN1, SNCA, HMOX1, HRAS, HTT, BDNF
23	response to drug	GO:042493	9.4	NPC1, TSPO, SMPD1, SNCA, MAOB, APOD
24	small molecule metabolic process	GO:044281	9.3	SMPD1, SMPD2, ABCA1, ACHE, HEXA, PSAP
25	anti-apoptosis	GO:006916	9.2	CRYAB, RPS27A, PSEN1, SQSTM1, SNCA, HMOX1
26	stress-activated MAPK cascade	GO:051403	9.2	RPS27A, CRYAB, MAPK1, MAPK3, ATF2
27	TRIF-dependent toll-like receptor signaling pathway	GO:035666	9.1	ATF2, MAPK3, MAPK1, RPS27A, TLR4
28	toll-like receptor 1 signaling pathway	GO:034130	9.1	TLR4, RPS27A, MAPK1, MAPK3, ATF2
29	toll-like receptor 3 signaling pathway	GO:034138	9.0	TLR4, RPS27A, MAPK1, MAPK3, ATF2
30	toll-like receptor 2 signaling pathway	GO:034134	9.0	TLR4, RPS27A, MAPK1, MAPK3, ATF2
31	regulation of sequence-specific DNA binding transcription factor activity	GO:051090	9.0	ATF2, MAPK3, MAPK1, HMOX1
32	toll-like receptor signaling pathway	GO:002224	9.0	TLR4, RPS27A, MAPK1, MAPK3, ATF2
33	MyD88-dependent toll-like receptor signaling pathway	GO:002755	9.0	ATF2, MAPK3, MAPK1, RPS27A, TLR4
34	toll-like receptor 4 signaling pathway	GO:034142	8.8	ATF2, MAPK3, MAPK1, RPS27A, TLR4
35	MAPK cascade	GO:000165	8.6	HRAS, CCL3, MAPK1, MAPK3, SCG2, MYC
36	Toll signaling pathway	GO:008063	8.5	TLR4, RPS27A, MAPK1, MAPK3, ATF2
37	nerve growth factor receptor signaling pathway	GO:048011	8.4	SQSTM1, PSEN1, RPS27A, SMPD2, HRAS, CASP3
38	synaptic transmission	GO:007268	8.3	HRAS, PLCB1, PLP1, ACHE, HCRT, NEFL

Molecular functions related to pick's disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cation binding	GO:043169	10.2	NAGA, CHIT1, HEXA, GBA
2	cholesterol binding	GO:015485	9.9	NPC2, NPC1, SYP, TSPO, ABCA1, APOD
3	tau protein binding	GO:048156	9.9	SNCA, DYRK1A, APOE
4	protein binding	GO:005515	3.9	ADAMTS5, ACHE, ABCA1, WWP2, NOTCH1, CRYAB