Pigment Disorder malady

MalaCards: Pigment Disorder, also known as pigmentation disorders, is related to pigmentation disease and microglandular adenosis. An important gene associated with Pigment Disorder is PDR (pigment disorder, reticulate), and among its related pathways are Melanoma and Melanocyte Development and Pigmentation. The compounds ptk787 and zd6474 have been mentioned in the context of this disorder. Related mouse phenotypes are hearing/vestibular/ear and pigmentation.

pigment disorder 7 pigmentation disorders 43

Diseases related to pigment disorder by text searches and GeneDecks gene sharing:

(show top 50)    (show all 55)

id	Related Disease	Score	Top Affiliating Genes
1	pigmentation disease	27.0	TYR, MITF, KIT
2	microglandular adenosis	12.8	EGFR, KIT
3	ampulla of vater carcinoma	12.8	KIT, EGFR
4	uterine carcinosarcoma	12.8	EGFR, KIT
5	salivary gland cancer	12.8	KIT, EGFR
6	thymic epithelial tumor	12.7	KIT, EGFR
7	kidney clear cell sarcoma	12.7	KIT, MITF
8	adenosquamous carcinoma	12.7	KIT, EGFR
9	thymic carcinoma	12.7	EGFR, KIT
10	piebaldism	12.7	MITF, KIT
11	mast cell neoplasm	12.7	KIT, MITF
12	perivascular epithelioid cell tumor	12.7	KIT, MITF
13	chromophobe renal cell carcinoma	12.7	EGFR, KIT
14	juvenile xanthogranuloma	12.5	KIT, TYR
15	mastocytosis	12.4	KIT, MITF
16	biliary tract cancer	12.4	EGFR, KIT
17	waardenburg syndrome type 2	12.4	MITF, TYR
18	posterior uveal melanoma	12.4	MITF, TYR
19	melanoma metastasis	12.4	MITF, KIT
20	nephroblastoma	12.3	EGFR, KIT
21	ocular albinism	12.3	TYR, MITF
22	intraocular melanoma	12.2	MITF, TYR
23	malignant peripheral nerve sheath tumor	12.2	EGFR, KIT, MITF
24	paraganglioma	12.1	EGFR, KIT
25	factor vii deficiency	12.0	KIT, EGFR, TYR
26	neuroendocrine carcinoma	12.0	EGFR, KIT, TYR
27	hyperpigmentation of eyelid	12.0	MITF, TYR, KIT
28	vaginitis	12.0	EGFR, KIT, TYR
29	waardenburg's syndrome	11.9	KIT, TYR, MITF
30	oculocutaneous albinism	11.9	TYR, MITF, KIT
31	neurilemmoma	11.9	KIT, TYR, MITF
32	fibrosarcoma	11.9	TYR, EGFR, KIT
33	albinism	11.9	KIT, MITF, TYR
34	microphthalmia	11.9	KIT, TYR, MITF
35	vitiligo	11.9	TYR, KIT, MITF
36	skin disease	11.8	TYR, EGFR, MITF
37	pertussis	11.7	MITF, TYR, EGFR
38	nasopharyngitis	11.6	KIT, EGFR, TYR
39	carney complex	11.4	TYR, KIT, MITF, EGFR
40	angiomyolipoma	11.4	KIT, MITF, EGFR, TYR
41	neurofibroma	11.4	TYR, EGFR, KIT, MITF
42	nevus	11.4	EGFR, TYR, KIT, MITF
43	cutaneous malignant melanoma	11.4	MITF, EGFR, TYR, KIT
44	retinoblastoma	11.4	KIT, TYR, EGFR, MITF
45	renal cell carcinoma	11.3	KIT, EGFR, MITF, TYR
46	sarcoma	11.2	KIT, MITF, TYR, EGFR
47	retinitis	11.1	TYR, MITF, KIT, EGFR
48	skin pigmentation disorders	8.0
49	pigment disorder, reticulate	6.6
50	anterior corneal pigmentation	6.1

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to pigment disorder:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hearing/vestibular/ear phenotype	MP:0005377	8.5	KIT, MITF, EGFR
2	pigmentation phenotype	MP:0001186	8.2	TYR, EGFR, MITF, KIT
3	limbs/digits/tail phenotype	MP:0005371	8.2	KIT, MITF, EGFR, TYR
4	no phenotypic analysis	MP:0003012	8.2	TYR, EGFR, MITF, KIT
5	vision/eye phenotype	MP:0005391	8.1	MITF, TYR, EGFR, KIT
6	skeleton phenotype	MP:0005390	8.1	TYR, EGFR, MITF, KIT
7	integument phenotype	MP:0010771	8.1	KIT, EGFR, MITF, TYR
8	endocrine/exocrine gland phenotype	MP:0005379	8.0	KIT, TYR, EGFR, MITF
9	reproductive system phenotype	MP:0005389	8.0	KIT, EGFR, TYR, MITF
10	normal phenotype	MP:0002873	7.9	MITF, EGFR, TYR, KIT

Articles related to pigment disorder:

id	Title	Authors	Year	Affiliating Genes
1	Mitogen-activated protein/extracellular signal-regula ted kinase kinase inhibition results in biphasic alteration of epidermal homeos tasis with keratinocytic apoptosis and pigmentation disorders. (20103661)	Schad K.... Dummer R.	2010	EGFR
2	Factors affecting melanogenesis and methods used for identification of pigmentation disorders (18942345)	Galus R.... WA8odarski K.	2008	TYR

Genes related to pigment disorder according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	PDR	pigment disorder, reticulate	11.1	Aliases & Descriptions
2	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.0
3	MITF	microphthalmia-associated transcription factor	11.0
4	TYR	tyrosinase (oculocutaneous albinism IA)	11.0	Publications
5	EGFR	epidermal growth factor receptor	11.0	Publications

Pathways related to pigment disorder according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Melanoma20	9.3	EGFR, MITF
2	Melanocyte Development and Pigmentation36	9.0	MITF, KIT
3	Pathways in cancer20	8.7	KIT, EGFR, MITF
4	Melanogenesis20	8.5	TYR, MITF, KIT

Compounds related to pigment disorder according to GeneDecks:

(show all 26)

id	Compound	Score	Top Affiliating Genes
1	ptk78732	9.8	EGFR, KIT
2	zd647432	9.8	EGFR, KIT
3	everolimus32 9 9	11.8	EGFR, KIT
4	ag-129632	9.8	KIT, EGFR
5	su541632	9.8	EGFR, KIT
6	capecitabine32 34 9 9	12.7	EGFR, KIT
7	sunitinib32 9 9	11.7	KIT, EGFR
8	dasatinib32 34 9 9	12.7	EGFR, KIT
9	erlotinib32 34 9 9	12.7	KIT, EGFR
10	sorafenib32 9 9	11.6	KIT, EGFR
11	flavopiridol32 9 9	11.6	KIT, EGFR
12	trastuzumab32 34 9 9	12.6	KIT, EGFR
13	irinotecan32 34 9 9	12.5	EGFR, KIT
14	L-Tyrosine9 18 9	11.5	TYR, EGFR
15	gefitinib32 34 9 9	12.4	KIT, EGFR
16	kojic acid32	9.4	TYR, MITF
17	bcnu32	9.4	TYR, EGFR
18	dopachrome32	9.4	MITF, TYR
19	hmba32	9.3	TYR, MITF
20	docetaxel32 34 9 9	12.1	KIT, EGFR
21	paclitaxel32 34 9 9	11.9	TYR, EGFR, KIT
22	doxorubicin32 34 9 9	11.8	KIT, EGFR, TYR
23	cycloheximide32	8.7	EGFR, TYR, KIT
24	testosterone32 9 18 9	11.6	EGFR, KIT, TYR
25	paraffin32	8.4	TYR, EGFR, MITF, KIT
26	tyrosine32	7.9	MITF, KIT, EGFR, TYR

Biological processes related to pigment disorder according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	melanocyte differentiation	GO:030318	9.3	KIT, MITF

Molecular functions related to pigment disorder according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	protein tyrosine kinase activity	GO:004713	9.4	KIT, EGFR
2	receptor signaling protein tyrosine kinase activity	GO:004716	9.3	KIT, EGFR
3	transmembrane receptor protein tyrosine kinase activity	GO:004714	9.1	KIT, EGFR