MCID: PGM001
MIFTS: 54

Pigmented Villonodular Synovitis

Categories: Rare diseases, Muscle diseases, Reproductive diseases, Bone diseases

Aliases & Classifications for Pigmented Villonodular Synovitis

MalaCards integrated aliases for Pigmented Villonodular Synovitis:

Name: Pigmented Villonodular Synovitis 12 72 49 55 14 69
Tenosynovial Giant Cell Tumor 49 55
Diffuse-Type Giant Cell Tumor 49 55
Diffuse-Type Gct 49 55
Tsgct 49 55
Tgct 49 55
Localized Pigmented Villonodular Synovitis 49
Diffuse Giant Cell Tumor of Tenosynovium 12
Diffuse Pigmented Villonodular Synovitis 49
Fibrous Histiocytoma of Tendon Sheath 69
Synovitis, Pigmented Villonodular 41
Synovitis Pigmented Villonodular 51
Tenosynovial Giant Cell Tumors 49
Testicular Germ Cell Tumor 69
Villous Tenosynovitis 12

Characteristics:

Orphanet epidemiological data:

55
pigmented villonodular synovitis
Inheritance: Not applicable;

Classifications:



External Ids:

Disease Ontology 12 DOID:2702
ICD10 32 M12.2
MeSH 41 D013586
NCIt 46 C3401
Orphanet 55 ORPHA66627
MESH via Orphanet 42 D013586
UMLS via Orphanet 70 C0039106
ICD10 via Orphanet 33 M12.2
UMLS 69 C0039106

Summaries for Pigmented Villonodular Synovitis

NIH Rare Diseases : 49 Pigmented villonodular synovitis (PVNS) is a disease in which the tissue lining the joints and tendons in the body (synovium) grows abnormally. It is characterized by a noncancerous mass or tumor. There are two types of PVNS: the local or nodular form (where the tumor involves the tendons that support the joint, or in one area of the joint) and the diffuse form (where the entire lining of the joint is involved). Symptoms might include: pain, limitation of movement, and locking of the joint. In some cases, the normal joint structure can be destroyed. The knee is most commonly affected by this condition, though it can occur in other joints such as the hip, shoulder, elbow, ankle, wrist, and rarely the jaw. The average age of diagnosis for this condition is 35 years. The cause of PVNS is unknown. Treatment involves surgery to remove the tumor and damaged portions of the synovium. Last updated: 4/4/2016

MalaCards based summary : Pigmented Villonodular Synovitis, also known as tenosynovial giant cell tumor, is related to villonodular synovitis and tenosynovial giant cell tumor, and has symptoms including pain An important gene associated with Pigmented Villonodular Synovitis is CSF1 (Colony Stimulating Factor 1), and among its related pathways/superpathways are Innate Immune System and PAK Pathway. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 72 Pigmented villonodular synovitis (PVNS) is a joint disease characterized by inflammation and overgrowth... more...

Related Diseases for Pigmented Villonodular Synovitis

Diseases related to Pigmented Villonodular Synovitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 villonodular synovitis 32.7 ACP5 MMP9 PTPN11 TNFSF11
2 tenosynovial giant cell tumor 31.1 CSF1 CSF1R
3 arthritis 30.5 CSF1 MMP9 TNFSF11
4 giant cell tumor 30.5 CSF1 MMP9 PTPRC TNFSF11
5 osteonecrosis 30.4 ACP5 TNFSF11
6 malignant giant cell tumor 30.4 ACP5 TP53
7 bone giant cell tumor 30.2 ACP5 CALCR
8 rheumatoid arthritis 30.0 ACP5 CSF1 CSF1R TNFSF11
9 noonan syndrome 1 12.1
10 testicular germ cell tumor 12.1
11 synovitis 11.4
12 episodic pain syndrome, familial, 1 10.5
13 tooth resorption 10.3 ACP5 TNFSF11
14 hypercementosis 10.3 ACP5 MMP9
15 enchondromatosis, multiple, ollier type 10.3 ACP5 PTPN11
16 glucocorticoid-induced osteoporosis 10.3 ACP5 TNFSF11
17 ischemic bone disease 10.3 ACP5 TNFSF11
18 mandibular cancer 10.3 CSF1 TNFSF11
19 periodontosis 10.3 MMP9 TNFSF11
20 cholesteatoma of middle ear 10.3 MMP9 TNFSF11
21 malignant giant cell tumor of soft parts 10.3 ACP5 PTPRC
22 jaw cancer 10.2 CSF1 TNFSF11
23 popliteal cyst 10.2
24 mycobacterium tuberculosis 1 10.2
25 sarcoma 10.2
26 synovium cancer 10.2
27 neuropathy 10.2
28 synovial chondromatosis 10.2
29 adamantinoma of long bones 10.2 CSF1 TNFSF11
30 joint disorders 10.2 CSF1 TNFSF11
31 testicular germ cell tumor 1 10.2
32 germ cells tumors 10.2
33 photokeratitis 10.2 MMP9 PTPRC
34 bone resorption disease 10.2 ACP5 TNFSF11
35 carpal tunnel syndrome 10.2
36 mononeuropathy of the median nerve, mild 10.2
37 osteoarthritis 10.2
38 hemarthrosis 10.2
39 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.1 CSF1 CSF1R
40 endosteal hyperostosis, autosomal dominant 10.1 CSF1 TNFSF11
41 bone remodeling disease 10.1 ACP5 TNFSF11
42 histiocytic sarcoma 10.1 CSF1 CSF1R
43 periapical periodontitis 10.1 ACP5 MMP9 TNFSF11
44 primary progressive multiple sclerosis 10.1 CSF1R MMP9
45 malignant histiocytosis 10.1 CSF1 CSF1R
46 cherubism 10.1 CSF1 PTPN11 TNFSF11
47 paget's disease of bone 10.0 ACP5 CSF1 TNFSF11
48 spondyloarthropathy 1 10.0
49 lipomatosis, multiple 10.0
50 systemic lupus erythematosus 10.0

Graphical network of the top 20 diseases related to Pigmented Villonodular Synovitis:



Diseases related to Pigmented Villonodular Synovitis

Symptoms & Phenotypes for Pigmented Villonodular Synovitis

UMLS symptoms related to Pigmented Villonodular Synovitis:


pain

GenomeRNAi Phenotypes related to Pigmented Villonodular Synovitis according to GeneCards Suite gene sharing:

25 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.68 PTPRC
2 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.68 PTPN11
3 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.68 CALCR PTPN11 PTPRC
4 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.68 PTPN11
5 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.68 CALCR
6 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.68 PTPN11 PTPRC
7 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.68 PTPN11
8 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.68 PTPN11
9 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.68 CALCR
10 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.68 PTPRC
11 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.68 PTPRC
12 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.68 CALCR
13 Increased shRNA abundance (Z-score > 2) GR00366-A-37 9.68 PTPN11
14 Increased shRNA abundance (Z-score > 2) GR00366-A-41 9.68 PTPRC
15 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.68 PTPN11
16 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.68 PTPRC
17 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.68 PTPN11
18 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.68 PTPN11
19 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.68 CALCR
20 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.68 CALCR
21 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.26 ACP5 CSF1R PTPN11 PTPRC

MGI Mouse Phenotypes related to Pigmented Villonodular Synovitis:

43 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.14 TNFSF11 PTPN11 CSF1R CALCR PTPRC CSF1
2 homeostasis/metabolism MP:0005376 10.13 PTPN11 TNFSF11 CSF1R CALCR PTPRC CSF1
3 immune system MP:0005387 10.11 TNFSF11 PTPN11 CSF1R CALCR PTPRC CSF1
4 growth/size/body region MP:0005378 10.1 MMP9 CSF1 TP53 PTPN11 TNFSF11 CSF1R
5 mortality/aging MP:0010768 10.06 PTPN11 TNFSF11 CSF1R CALCR CSF1 PTPRC
6 endocrine/exocrine gland MP:0005379 10.04 TP53 PTPN11 TNFSF11 CSF1R PTPRC CSF1
7 limbs/digits/tail MP:0005371 10.02 TNFSF11 PTPN11 CSF1R CALCR CSF1 TP53
8 craniofacial MP:0005382 9.97 PTPN11 TNFSF11 CSF1R CSF1 TP53
9 integument MP:0010771 9.97 PTPN11 TNFSF11 CSF1R CSF1 TP53 MMP9
10 hearing/vestibular/ear MP:0005377 9.85 CSF1 PTPN11 CSF1R TP53
11 no phenotypic analysis MP:0003012 9.85 TNFSF11 PTPN11 CSF1R PTPRC CSF1 TP53
12 muscle MP:0005369 9.83 MMP9 CSF1 TP53 PTPN11 TNFSF11
13 neoplasm MP:0002006 9.8 PTPN11 TNFSF11 PTPRC TP53 MMP9
14 normal MP:0002873 9.8 PTPN11 TNFSF11 CSF1R CALCR PTPRC TP53
15 reproductive system MP:0005389 9.73 TP53 PTPN11 TNFSF11 CSF1R CSF1 MMP9
16 respiratory system MP:0005388 9.63 TNFSF11 PTPN11 PTPRC CSF1 TP53 MMP9
17 skeleton MP:0005390 9.56 TNFSF11 PTPN11 CSF1R CALCR PTPRC CSF1
18 vision/eye MP:0005391 9.02 MMP9 CSF1 TNFSF11 PTPN11 TP53

Drugs & Therapeutics for Pigmented Villonodular Synovitis

Drugs for Pigmented Villonodular Synovitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 1, Phase 2
2 Immunoglobulins Phase 1, Phase 2
3 Grapefruit Seed Extract Nutraceutical Phase 2
4
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
5
Midazolam Approved, Illicit Phase 1 59467-70-8 4192
6
Warfarin Approved Phase 1 81-81-2 54678486 6691
7
Menadione Approved, Nutraceutical Phase 1 58-27-5 4055
8
Phytonadione Approved, Investigational, Nutraceutical Phase 1 84-80-0 5284607 4812
9 Albumin-Bound Paclitaxel Phase 1
10 Antimitotic Agents Phase 1
11 Antineoplastic Agents, Phytogenic Phase 1
12 Adjuvants, Anesthesia Phase 1
13 Anesthetics Phase 1
14 Anesthetics, General Phase 1
15 Anesthetics, Intravenous Phase 1
16 Anti-Anxiety Agents Phase 1
17 Anticoagulants Phase 1
18 Antifibrinolytic Agents Phase 1
19 Central Nervous System Depressants Phase 1
20 Coagulants Phase 1
21 GABA Agents Phase 1
22 GABA Modulators Phase 1
23 Hemostatics Phase 1
24 Hypnotics and Sedatives Phase 1
25 Micronutrients Phase 1
26 Neurotransmitter Agents Phase 1
27 Psychotropic Drugs Phase 1
28 Trace Elements Phase 1
29 Tranquilizing Agents Phase 1
30 Vitamins Phase 1
31 Menaquinone Nutraceutical Phase 1
32 naphthoquinone Nutraceutical Phase 1
33 Vitamin K Nutraceutical Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 PLX3397 Phase 3 Study for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS) Active, not recruiting NCT02371369 Phase 3 PLX3397;Placebo
2 Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT) Completed NCT01261429 Phase 2 Tasigna
3 Study of FPA008 in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell Tumor Recruiting NCT02471716 Phase 1, Phase 2 FPA008
4 MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCTTS) Active, not recruiting NCT01643850 Phase 2 MCS110;Placebo
5 Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell Tumor Active, not recruiting NCT01207492 Phase 2 nilotinib
6 A Study of PLX73086 in Advanced Solid Tumors and Locally Advanced or Refractory Tenosynovial Giant Cell Tumor Active, not recruiting NCT02673736 Phase 1 PLX73086
7 Phase 1 Study of PLX7486 as Single Agent in Patients With Advanced Solid Tumors Active, not recruiting NCT01804530 Phase 1 PLX7486 TsOH
8 A Study of RO5509554 as Monotherapy and in Combination With Paclitaxel in Participants With Advanced Solid Tumors Active, not recruiting NCT01494688 Phase 1 Paclitaxel;RO5509554
9 Pexidartinib Effects on How the Body Processes Midazolam and S-warfarin (Pharmacokinetics) Not yet recruiting NCT03291288 Phase 1 S-warfarin;Midazolam;Pexidartinib
10 Tenosynovial Giant Cell Tumors (TGCT) Observational Platform Project Recruiting NCT02948088

Search NIH Clinical Center for Pigmented Villonodular Synovitis

Cochrane evidence based reviews: synovitis, pigmented villonodular

Genetic Tests for Pigmented Villonodular Synovitis

Anatomical Context for Pigmented Villonodular Synovitis

MalaCards organs/tissues related to Pigmented Villonodular Synovitis:

38
Bone, Testes, Lung

Publications for Pigmented Villonodular Synovitis

Articles related to Pigmented Villonodular Synovitis:

(show top 50) (show all 596)
# Title Authors Year
1
Pigmented villonodular synovitis in pediatric population: review of literature and a case report. ( 29343257 )
2018
2
Pigmented Villonodular Synovitis: A Close Mimic of Metastasis on<sup>18</sup>F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography. ( 29430127 )
2018
3
An unusual case of diffuse pigmented villonodular synovitis of the shoulder: A multidisciplinary approach with arthroscopic synovectomy and adjuvant radiotherapy. ( 28638690 )
2017
4
Pigmented villonodular synovitis of the knee: A retrospective analysis of 214 cases at a UK tertiary referral centre. ( 28442184 )
2017
5
Intra-articular Localized Haemangioma of the Knee Mimicking Localized Pigmented Villonodular Synovitis: A Case Report. ( 28435577 )
2017
6
Arthroscopic treatment of intra-artricularly localised pigmented villonodular synovitis of the ankle: 4 cases with long-term follow-up. ( 29202997 )
2017
7
Localized pigmented villonodular synovitis of posterior compartment of the knee. ( 28847242 )
2017
8
Pigmented Villonodular Synovitis - Various Manifestations, Inconsistent Terminology and Treatment. Cases Study. ( 28436371 )
2017
9
Localized pigmented villonodular synovitis of the ankle: Expect the unexpected. ( 28159047 )
2017
10
Diffuse pigmented villonodular synovitis in knee joint: diagnosis and treatment. ( 28884104 )
2017
11
Open and Arthroscopic with Mini-Open Surgical Hip Approaches for Treatment of Pigmented Villonodular Synovitis and Concomitant Hip Pathology. ( 28326214 )
2017
12
Surgical treatment for diffused-type giant cell tumor (pigmented villonodular synovitis) about the ankle joint. ( 29137617 )
2017
13
PIGMENTED VILLONODULAR SYNOVITIS IN A RETICULATED GIRAFFE (GIRAFFA CAMELOPARDALIS). ( 28749260 )
2017
14
Long-term outcome of knee arthroplasty in the setting of pigmented villonodular synovitis. ( 28552192 )
2017
15
Long-Term Outcome of Hip Arthroplasty in the Setting of Pigmented Villonodular Synovitis. ( 29352684 )
2017
16
Long-term outcome of pigmented villonodular synovitis of the hip after joint preserving therapy. ( 29282525 )
2017
17
Systematic Arthroscopic Treatment of Diffuse Pigmented Villonodular Synovitis in the Knee. ( 29354472 )
2017
18
Diffuse Pigmented Villonodular Synovitis as a Rare Cause of Graft Failure Following Anterior Cruciate Ligament Reconstruction. ( 28776631 )
2017
19
Localized pigmented villonodular synovitis in a child knee. ( 28291439 )
2017
20
Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis). ( 28057477 )
2017
21
Pigmented Villonodular Synovitis of the Temporomandibular Joint With Petrous Bone Invasion. ( 28333775 )
2017
22
Results and recurrence of pigmented villonodular synovitis of the ankle: does diffuse PVNS with extra-articular extension tend to recur more often? ( 28389877 )
2017
23
Multifocal pigmented villonodular synovitis coexisting in both the knee joint and the patella: a case report and literature review. ( 28683727 )
2017
24
Pigmented Villonodular Synovitis of Thumb-A Cytological Diagnosis. ( 28764182 )
2017
25
A rare case of localised pigmented villonodular synovitis in the knee of a 24-year-old female soccer player: diagnosis, management and summary of tenosynovial giant cell tumours. ( 28978573 )
2017
26
Pigmented Villonodular Synovitis: A Comprehensive Review and Proposed Treatment Algorithm. ( 27509331 )
2016
27
Pigmented Villonodular Synovitis of the Hip: A Systematic Review. ( 26761914 )
2016
28
Tumorlike Pigmented Villonodular Synovitis With Atypical Location: Appearance on 3-Phase 99mTc-MDP Bone Scan. ( 28005642 )
2016
29
Pigmented villonodular synovitis of the hip. ( 28461957 )
2016
30
Pigmented Villonodular Synovitis of the Knee Joint: A Case Report. ( 27843734 )
2016
31
Functional Reconstruction of Temporomandibular Joint after Resection of Pigmented Villonodular Synovitis with Extension to Infratemporal Fossa and Skull Base: A Case Report. ( 28824995 )
2016
32
A systematic literature review of synovial chondromatosis and pigmented villonodular synovitis of the hip. ( 27462929 )
2016
33
Current Systemic Treatment Options for Tenosynovial Giant Cell Tumor/Pigmented Villonodular Synovitis: Targeting the CSF1/CSF1R Axis. ( 26820289 )
2016
34
Pigmented villonodular synovitis of proximal tibiofibular joint: Rare site of involvement treated with medical management. ( 28032093 )
2016
35
Arthroscopically-assisted mini open partial synovectomy for the treatment of localized pigmented villonodular synovitis of the knee. A retrospective comparative study with long-term follow up. ( 27866235 )
2016
36
Osteonecrosis of the femoral head associated with pigmented villonodular synovitis. ( 27928593 )
2016
37
Pigmented Villonodular Synovitis of the Temporomandibular Joint: A Unique Presentation. ( 27200236 )
2016
38
Pigmented villonodular synovitis: a crowdsourcing study of two hundred and seventy two patients. ( 27169531 )
2016
39
Pigmented villonodular synovitis of the knee joint in a 5-year-old girl treated with combined open and arthroscopic surgery: a case report. ( 26919624 )
2016
40
Arthroscopic surgical treatment of pigmented villonodular synovitis of the elbow: case report. ( 27517031 )
2016
41
Pigmented villonodular synovitis mimics metastases on fluorine 18 fluorodeoxyglucose position emission tomography-computed tomography. ( 27190776 )
2016
42
Locked hip joint: an uncommon presentation of localized pigmented villonodular synovitis. ( 27130398 )
2016
43
Pigmented villonodular synovitis diagnosed during revision total knee arthroplasty for flexion instability and patellar fracture. ( 26810732 )
2016
44
Multifocal pigmented villonodular synovitis in a child: A case report. ( 27537585 )
2016
45
Organ-specific radiation-induced cancer risk estimates due to radiotherapy for benign pigmented villonodular synovitis. ( 27499236 )
2016
46
Pigmented villonodular synovitis of the temporomandibular joint: Case report and review of literature. ( 25821131 )
2015
47
Pigmented villonodular synovitis of temporomandibular joint: pathological aspects and surgical treatment. ( 25937582 )
2015
48
Expression of colony-stimulating factor 1 is associated with occurrence of osteochondral change in pigmented villonodular synovitis. ( 25854167 )
2015
49
Surgical outcomes after excision of pigmented villonodular synovitis localized to the ankle and hindfoot without adjuvant therapy. ( 25618808 )
2015
50
Pigmented villonodular synovitis of the temporomandibular joint with intracranial extension. ( 25699525 )
2015

Variations for Pigmented Villonodular Synovitis

Expression for Pigmented Villonodular Synovitis

Search GEO for disease gene expression data for Pigmented Villonodular Synovitis.

Pathways for Pigmented Villonodular Synovitis

Pathways related to Pigmented Villonodular Synovitis according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.7 CSF1 CSF1R MMP9 PTPN11 PTPRC TNFSF11
2
Show member pathways
12.94 CSF1 CSF1R PTPN11 PTPRC TNFSF11
3
Show member pathways
12.84 CSF1 CSF1R MMP9 PTPN11 TNFSF11 TP53
4
Show member pathways
12.08 ACP5 CALCR TNFSF11
5 12.01 MMP9 PTPN11 TP53
6
Show member pathways
11.98 PTPN11 TNFSF11 TP53
7 11.94 CSF1R MMP9 TP53
8 11.54 CSF1R PTPN11 PTPRC
9 11.53 ACP5 CSF1 TNFSF11
10 11.43 MMP9 PTPN11 PTPRC
11 11.37 CSF1 CSF1R PTPRC
12 11.31 PTPN11 TP53
13 11.3 CSF1 CSF1R
14 11.26 MMP9 PTPN11
15 11.24 CALCR TNFSF11
16
Show member pathways
11.2 CSF1 CSF1R
17 11.17 PTPN11 PTPRC
18 11.13 ACP5 CALCR CSF1 CSF1R TNFSF11
19 11.04 MMP9 PTPRC
20 11.01 CSF1 CSF1R TNFSF11
21 10.79 CSF1 CSF1R PTPN11
22 10.64 ACP5 TNFSF11

GO Terms for Pigmented Villonodular Synovitis

Cellular components related to Pigmented Villonodular Synovitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 CSF1-CSF1R complex GO:1990682 8.62 CSF1 CSF1R

Biological processes related to Pigmented Villonodular Synovitis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.65 CALCR CSF1R PTPN11
2 positive regulation of cell migration GO:0030335 9.63 CSF1 CSF1R MMP9
3 dephosphorylation GO:0016311 9.58 ACP5 PTPN11 PTPRC
4 cellular response to reactive oxygen species GO:0034614 9.54 MMP9 TP53
5 response to gamma radiation GO:0010332 9.52 PTPRC TP53
6 homeostasis of number of cells within a tissue GO:0048873 9.51 CSF1 PTPN11
7 positive regulation of protein kinase B signaling GO:0051897 9.5 CALCR PTPN11 TNFSF11
8 positive regulation of release of cytochrome c from mitochondria GO:0090200 9.49 MMP9 TP53
9 bone resorption GO:0045453 9.43 ACP5 TNFSF11
10 positive regulation of osteoclast differentiation GO:0045672 9.37 CSF1 TNFSF11
11 macrophage colony-stimulating factor signaling pathway GO:0038145 9.26 CSF1 CSF1R
12 osteoclast proliferation GO:0002158 9.16 CSF1 TNFSF11
13 macrophage differentiation GO:0030225 9.13 CSF1 CSF1R MMP9
14 osteoclast differentiation GO:0030316 8.92 CALCR CSF1 CSF1R TNFSF11

Molecular functions related to Pigmented Villonodular Synovitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor tyrosine kinase binding GO:0030971 8.62 PTPN11 TP53

Sources for Pigmented Villonodular Synovitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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