MCID: PGM001
MIFTS: 51

Pigmented Villonodular Synovitis malady

Bone, Muscle, Cancer categories

Summaries for Pigmented Villonodular Synovitis

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Pigmented villonodular synovitis is a disease in which the tissue lining a joint in the body begins to grow abnormally.  there are two types of pigmented villonodular synovitis: the nodular form (where the abnormal tissue growth forms a single bump) and the diffuse form (where the entire lining of the joint grows unusually).  the additional tissue in the joint can cause pain, limit movements or cause the joint to lock, and in some cases, can destroy the normal joint structure.  the knee is most commonly affected by this condition, though it can occur in other joints such as the hip, shoulder, elbow, ankle, or wrist.  the average age of diagnosis for this condition is 35 years. last updated: 11/28/2011

MalaCards: Pigmented Villonodular Synovitis, also known as localized pigmented villonodular synovitis, is related to synovitis and arthritis. An important gene associated with Pigmented Villonodular Synovitis is ACP5 (acid phosphatase 5, tartrate resistant), and among its related pathways are Osteopontin Signaling and Integrins in angiogenesis. The compounds pge2 and procollagen have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle and lung, and related mouse phenotypes are limbs/digits/tail and integument.

Wikipedia:64 Pigmented villonodular synovitis (PVNS) is a joint disease characterized by inflammation and overgrowth... more...

Aliases & Classifications for Pigmented Villonodular Synovitis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 35MeSH, 57SNOMED-CT, 40NCIt, 36MESH via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Bone, Muscle


Aliases & Descriptions:

pigmented villonodular synovitis 8 43 10 49 61
localized pigmented villonodular synovitis 43
diffuse giant cell tumor of tenosynovium 8
diffuse pigmented villonodular synovitis 43
fibrous histiocytoma of tendon sheath 61
synovitis pigmented villonodular 45
tenosynovial giant cell tumors 43
villous tenosynovitis 8


External Ids:

Disease Ontology8 DOID:2702
MeSH35 D013586
NCIt40 C3401
MESH via Orphanet36 D013586
SNOMED-CT via Orphanet58 95412009
UMLS via Orphanet62 C0039106

Related Diseases for Pigmented Villonodular Synovitis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pigmented Villonodular Synovitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 133)
idRelated DiseaseScoreTop Affiliating Genes
1synovitis32.4TNFSF11, TNFRSF11B, CD68, MMP1
2arthritis31.0ACP5, MMP9, MMP1, TNFRSF11B, TNFSF11, CSF1
3osteonecrosis30.6BGLAP
4squamous cell carcinoma30.4PTHLH, CSF1R, MMP1, SPP1, MMP9, IBSP
5osteoarthritis30.4PTHLH, BGLAP, SPP1, MMP9, MMP1, CD68
6villonodular synovitis11.6
7tenosynovial giant cell tumor10.8
8synovitis, chronic10.5
9noonan syndrome10.5
10carpal tunnel syndrome10.5
11hemarthrosis10.5
12n syndrome10.5
13tuberculosis10.5
14synovial chondromatosis10.5
15chronic pain10.5
16chondroblastoma10.3
17nodular tenosynovitis10.3
18ulnar neuropathy10.3
19systemic lupus erythematosus10.3
20reactive arthritis10.3
21peroneal neuropathy10.3
22bone giant cell tumor10.3
23osteochondroma10.3
24soft tissue sarcoma10.3
25spastic paraparesis10.3
26congenital plasminogen deficiency10.3
27polyploidy10.3
28neurofibromatosis10.3
29neurofibromatosis-noonan syndrome10.3
30multicentric reticulohistiocytosis10.0CD68
31histiocytosis10.0CD68
32adenoma10.0PVR
33adult t-cell leukemia10.0PTHLH
34root resorption10.0TNFRSF11B
35endometriosis10.0MMP1
36glomerulonephritis10.0SPP1
37cystic fibrosis10.0TNFRSF11B
38arteriosclerosis10.0SPP1
39myelofibrosis10.0PDGFRB
40leiomyosarcoma10.0PDGFRB
41hypertension10.0MMP9
42gastrointestinal stromal tumor10.0PDGFRB
43multiple myeloma10.0TNFSF11, TNFRSF11B
44uterine sarcoma10.0PDGFRB
45periodontal disease10.0MMP1, TNFSF11
46nephrolithiasis10.0SPP1
47osteosclerosis10.0TNFRSF11B, TNFSF11
48bronchopulmonary dysplasia10.0PTHLH
49paget disease, juvenile10.0TNFSF11, TNFRSF11B
50polyostotic osteolytic dysplasia, hereditary expansile10.0TNFSF11, TNFRSF11B

Graphical network of the top 20 diseases related to Pigmented Villonodular Synovitis:



Diseases related to pigmented villonodular synovitis

Clinical Features for Pigmented Villonodular Synovitis

Drugs & Therapeutics for Pigmented Villonodular Synovitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Pigmented Villonodular Synovitis

Search NIH Clinical Center for Pigmented Villonodular Synovitis

Search CenterWatch for Pigmented Villonodular Synovitis

Genetic Tests for Pigmented Villonodular Synovitis

Anatomical Context for Pigmented Villonodular Synovitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Pigmented Villonodular Synovitis:

33
Skeletal muscle, Lung

Animal Models for Pigmented Villonodular Synovitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Pigmented Villonodular Synovitis

Sources:
51PubMed
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Articles related to Pigmented Villonodular Synovitis:

(show top 50)    (show all 495)
idTitleAuthorsYear
1
Arthroscopic synovectomy in pigmented villonodular synovitis of the knee: clinical series and outcome. (23860791)
2013
2
A low recurrence rate is possible with a combination of surgery and radiosynovectomy for diffuse pigmented villonodular synovitis of the knee. (23751823)
2013
3
Low-dose external beam radiotherapy as a postoperative treatment for patients with diffuse pigmented villonodular synovitis of the knee: 4 recurrences in 23 patients followed for mean 9 years. (22489888)
2012
4
Hip joint pigmented villonodular synovitis in a young girl: a case report. (22433958)
2012
5
Pigmented villonodular synovitis of the temporomandibular joint: a radiologic diagnosis and case report. (21783297)
2012
6
Simultaneous anterior and posterior synovectomies for treating diffuse pigmented villonodular synovitis. (22359272)
2012
7
Destructive synovial hemangioma of the hip resembling pigmented villonodular synovitis. (20570091)
2011
8
Treatment of tenosynovial giant cell tumor and pigmented villonodular synovitis. (21577109)
2011
9
Pigmented villonodular synovitis of the knee: A case report. (23396820)
2011
10
Pigmented villonodular synovitis of the ankle-radiation therapy as a primary treatment to reduce recurrence: a case report with 8-year follow-up. (21172644)
2011
11
Excision of extensive midfoot pigmented villonodular synovitis with microvascular anastamosis of iliac crest bone graft using external fixation: a case report. (21926367)
2011
12
Synovial colony-stimulating factor-1 mRNA expression in diffuse pigmented villonodular synovitis. (21640049)
2011
13
Metal-on-metal hip resurfacing in patients with pigmented villonodular synovitis: a report of two cases. (20055355)
2010
14
Pigmented villonodular synovitis in both hindfeet. (19399199)
2009
15
What is your diagnosis? Quiz: diffuse-pigmented villonodular synovitis. (19230068)
2009
16
Outcomes after excision of pigmented villonodular synovitis of the knee. (19543865)
2009
17
Use of polymethylmethacrylate to treat pigmented villonodular synovitis in the posterior compartment of the knee. (17929044)
2008
18
Postoperative management of pigmented villonodular synovitis in a single subject. (19047769)
2008
19
Pigmented villonodular synovitis of the pes anserine bursa. (17665791)
2007
20
Pigmented villonodular synovitis of the calcaneocuboid joint in an 11-year-old child with subtalar coalition. (17475149)
2007
21
Tenosynovial giant cell tumor and pigmented villonodular synovitis. (17579851)
2007
22
Pigmented villonodular synovitis with chondroid metaplasia, resembling chondroblastoma of the bone: a report of three cases. (17334342)
2007
23
Strong expression of Bcl-2 in pigmented villonodular synovitis of the knee with aggressive clinical behaviour. (15903030)
2005
24
Pigmented villonodular synovitis: a disease in evolution. (15290750)
2004
25
Comparative analysis of cell populations involved in the proliferative and inflammatory processes in diffuse and localised pigmented villonodular synovitis. (15168328)
2004
26
MR imaging features of pigmented villonodular synovitis of the cervical spine. (14729546)
2004
27
Extra-articular pigmented villonodular synovitis. (15866798)
2004
28
MRI features of pigmented villonodular synovitis (PVNS). (14749979)
2004
29
Pigmented villonodular synovitis of the anserine bursa. (12817733)
2003
30
Pigmented villonodular synovitis and giant cell tumor of the tendon sheath: scintigraphic findings in 10 cases. (14578700)
2003
31
Successful arthroscopic treatment of pigmented villonodular synovitis of the knee in a patient with congenital deficiency of plasminogen activator inhibitor-1 and recurrent haemarthrosis. (11684866)
2001
32
Open synovectomy with cryosurgical adjuvant for treatment of diffuse pigmented villonodular synovitis of the knee. (10983259)
2000
33
Localized pigmented villonodular synovitis of the knee joint: neoplasm or reactive granuloma? A review of 18 cases. (10725067)
2000
34
Pigmented villonodular synovitis of the shoulder: review and case report. (10462217)
1999
35
Extra-articular pigmented villonodular synovitis of the temporomandibular joint. (9578883)
1998
36
Localized pigmented villonodular synovitis of the knee: arthroscopic treatment. (9788377)
1998
37
Malignancy in pigmented villonodular synovitis. (9730332)
1998
38
Pigmented villonodular synovitis. Report of a case with diagnostic synovial fluid cytologic features. (9390148)
1997
39
Pigmented villonodular synovitis in the first metatarsophalangeal joint: arthroscopic treatment of an unusual condition. (9278745)
1997
40
Diffuse pigmented villonodular synovitis in a college football player. (9090628)
1997
41
Multifocal pigmented villonodular synovitis in a child. A case report. (8542696)
1996
42
Pigmented villonodular synovitis in children. A case report. (8323846)
1993
43
Pigmented villonodular synovitis of the knee. The results of total arthroscopic synovectomy, partial, arthroscopic synovectomy, and arthroscopic local excision. (1463472)
1992
44
Pigmented villonodular synovitis presenting as a subcutaneous mass at the knee. (1629838)
1992
45
Pigmented villonodular synovitis of the hip. A case report and review of the literature. (1914420)
1991
46
Pigmented villonodular synovitis in a vertebra. A case report. (2365726)
1990
47
The use of MRI to assist in diagnosis of pigmented villonodular synovitis of the knee joint. (3370868)
1988
48
Magnetic resonance imaging of pigmented villonodular synovitis: a report of two cases. (3616670)
1987
49
Localized pigmented villonodular synovitis of the knee mimicking meniscal injury. (3801100)
1986
50
Pigmented villonodular synovitis-like lesions in association with rare cases of rheumatoid arthritis, osteonecrosis, and advanced degenerative joint disease. Report of five cases. (6697577)
1984

Genetic Variations for Pigmented Villonodular Synovitis

Expression for genes affiliated with Pigmented Villonodular Synovitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pigmented Villonodular Synovitis

Search GEO for disease gene expression data for Pigmented Villonodular Synovitis.

Pathways for genes affiliated with Pigmented Villonodular Synovitis

Sources:
38NCBI BioSystems Database, 52QIAGEN, 12EMD Millipore, 30KEGG
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Compounds for genes affiliated with Pigmented Villonodular Synovitis

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
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Compounds related to Pigmented Villonodular Synovitis according to GeneCards/GeneDecks:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1pge24510.6MMP9
2procollagen4510.5TNFSF11, ACP5
3cycloheximide4510.4CSF1R, IBSP
4rantes4510.0CALCR, CSF1, ACP5
5indomethacin45 60 29 1113.0SPP1, CSF1
6estradiol45 11 2412.0IBSP, CALCR, PTHLH, ACP5
7matrigel459.9PTHLH, PDGFRB, MMP1, IBSP
8clodronate45 50 1111.9TNFSF11, MMP1, ACP5, PTHLH, TNFRSF11B
9geranylgeranyl pyrophosphate459.8TNFSF11, TNFRSF11B, MMP9, MMP1
10prostaglandin459.8TNFRSF11B, CSF1, TNFSF11, MMP1
11etanercept45 50 1111.5TNFSF11, MMP1, CSF1, TNFRSF11B
12celecoxib45 60 29 50 11 2414.5MMP1, CSF1, MMP9, TNFRSF11B, TNFSF11
13ibandronate45 1110.4TNFSF11, TNFRSF11B, IBSP, BGLAP
14pyridinoline459.3ACP5, PTHLH, TNFRSF11B, IBSP, BGLAP
15deoxypyridinoline459.2TNFSF11, BGLAP, IBSP, TNFRSF11B, ACP5
16vitamin k2459.2BGLAP, CSF1, TNFRSF11B, TNFSF11
17pamidronate45 50 1111.2MMP1, PTHLH, TNFSF11, TNFRSF11B, BGLAP
18alendronate45 50 1111.2BGLAP, MMP1, TNFRSF11B, TNFSF11, PTHLH
19tgf beta1459.1CSF1, PDGFRB, PTHLH, SPP1, MMP9, MMP1
20infliximab45 50 1111.1SPP1, MMP1, TNFRSF11B, BGLAP, TNFSF11
21titanium459.1IBSP, BGLAP, SPP1, ACP5, TNFRSF11B, TNFSF11
22pd 98,059459.0CSF1R, CSF1, TNFSF11, MMP1, IBSP, SPP1
2325-hydroxyvitamin d459.0BGLAP, TNFSF11, PTHLH, SPP1, TNFRSF11B, ACP5
24phosphorus459.0TNFSF11, PTHLH, BGLAP, SPP1, ACP5, TNFRSF11B
25azathioprine45 50 2 1112.0TNFSF11, TNFRSF11B, ACP5, PTHLH, BGLAP
26genistein45 29 60 2 11 2413.9MMP9, SPP1, TNFRSF11B, TNFSF11, MMP1, PDGFRB
27troglitazone45 29 60 1111.9MMP1, SPP1, PTHLH, MMP9, CSF1
28tartrate458.9TNFSF11, CSF1, CALCR, BGLAP, ACP5, PTHLH
29ns 39845 609.8MMP9, TNFRSF11B, TNFSF11, CSF1, BGLAP, MMP1
30hydroxyapatite458.8PTHLH, SPP1, ACP5, TNFRSF11B, TNFSF11, IBSP
31hydroxyproline45 11 2410.8MMP9, BGLAP, TNFRSF11B, ACP5, PTHLH, MMP1
32zoledronic acid458.8BGLAP, IBSP, TNFRSF11B, MMP1, PTHLH, TNFSF11
33prednisolone45 29 1110.7BGLAP, TNFRSF11B, MMP1, PTHLH, CSF1
34heparin45 29 11 2411.6IBSP, SPP1, BGLAP, ACP5, TNFRSF11B, TNFSF11
35ascorbic acid45 249.6MMP1, TNFRSF11B, SPP1, TNFSF11, CSF1, IBSP
36serine458.4MMP1, TNFRSF11B, TNFSF11, CSF1, BGLAP, CSF1R
37sb 20358045 609.4SPP1, MMP9, MMP1, TNFRSF11B, TNFSF11, BGLAP
38phosphatidylinositol458.4CSF1, SPP1, TNFRSF11B, MMP9, PTHLH, CSF1R
39cyclosporin a45 29 6010.4TNFSF11, CALCR, BGLAP, TNFRSF11B, MMP9, MMP1
40dexamethasone45 50 29 1111.2TNFSF11, MMP9, ACP5, BGLAP, TNFRSF11B, SPP1
41testosterone45 60 11 2411.0MMP9, SPP1, PTHLH, MMP1, PDGFRB, TNFRSF11B
42vitamin d458.0CALCR, SPP1, PTHLH, ACP5, TNFRSF11B, PDGFRB
43tyrosine458.0ACP5, MMP9, TNFRSF11B, TNFSF11, CSF1, SPP1
441,25 dihydroxy vitamin d3458.0TNFRSF11B, PTHLH, ACP5, TNFSF11, CSF1, CSF1R
45calcitriol45 60 11 2410.9BGLAP, CALCR, MMP1, PDGFRB, CSF1, TNFSF11
46retinoic acid45 248.8PDGFRB, SPP1, PTHLH, MMP9, MMP1, BGLAP
47creatinine457.7TNFRSF11B, PTHLH, ACP5, MMP9, MMP1, TNFSF11
48cysteine457.7MMP9, MMP1, IBSP, TNFRSF11B, TNFSF11, BGLAP
49vegf457.6SPP1, MMP9, MMP1, TNFSF11, CSF1, CSF1R
50paraffin457.4PTHLH, CSF1, CSF1R, PDGFRB, IBSP, BGLAP

GO Terms for genes affiliated with Pigmented Villonodular Synovitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Pigmented Villonodular Synovitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane-bounded vesicleGO:0319889.4SPP1, BGLAP
2extracellular spaceGO:0056157.9SPP1, PVR, BGLAP, CSF1, TNFSF11, TNFRSF11B
3extracellular regionGO:0055767.8BGLAP, IBSP, TNFSF11, TNFRSF11B, MMP1, MMP9

Biological processes related to Pigmented Villonodular Synovitis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1osteoclast proliferationGO:00215810.1TNFSF11, CSF1
2positive regulation of bone resorptionGO:04578010.0SPP1, TNFSF11
3osteoclast differentiationGO:0303169.9TNFSF11, CSF1, CSF1R
4macrophage differentiationGO:0302259.9MMP9, CSF1, CSF1R
5phosphatidylinositol metabolic processGO:0464889.8CSF1R, PDGFRB
6ossificationGO:0015039.8IBSP, CSF1, TNFSF11
7extracellular matrix organizationGO:0301989.5IBSP, TNFRSF11B, MMP1, MMP9, SPP1
8regulation of bone resorptionGO:0451249.5CSF1R, BGLAP
9response to vitamin DGO:0332809.1SPP1, BGLAP
10skeletal system developmentGO:0015019.1BGLAP, TNFRSF11B, MMP9, PTHLH

Molecular functions related to Pigmented Villonodular Synovitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.5SPP1, TNFRSF11B, TNFSF11, CSF1

Products for genes affiliated with Pigmented Villonodular Synovitis

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Sources for Pigmented Villonodular Synovitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet