MCID: PGM001
MIFTS: 53

Pigmented Villonodular Synovitis malady

Rare diseases, Bone diseases, Reproductive diseases, Muscle diseases, Cancer diseases categories

Aliases & Classifications for Pigmented Villonodular Synovitis

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt, 34MESH via Orphanet, 61UMLS via Orphanet
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Pigmented Villonodular Synovitis, Aliases & Descriptions:

Name: Pigmented Villonodular Synovitis 9 41 11 47 60
Localized Pigmented Villonodular Synovitis 41
Diffuse Giant Cell Tumor of Tenosynovium 9
Diffuse Pigmented Villonodular Synovitis 41
Fibrous Histiocytoma of Tendon Sheath 60
Synovitis Pigmented Villonodular 43
Tenosynovial Giant Cell Tumors 41
 
Tenosynovial Giant Cell Tumor 47
Diffuse-Type Giant Cell Tumor 47
Testicular Germ Cell Tumor 60
Villous Tenosynovitis 9
Diffuse-Type Gct 47
Tsgct 47
Tgct 47


Classifications:



External Ids:

Disease Ontology9 DOID:2702
MeSH33 D013586
NCIt38 C3401
Orphanet47 66627
MESH via Orphanet34 D013586
UMLS via Orphanet61 C0039106

Summaries for Pigmented Villonodular Synovitis

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NIH Rare Diseases:41 Pigmented villonodular synovitis is a disease in which the tissue lining a joint in the body begins to grow abnormally.  there are two types of pigmented villonodular synovitis: the nodular form (where the abnormal tissue growth forms a single bump) and the diffuse form (where the entire lining of the joint grows unusually).  the additional tissue in the joint can cause pain, limit movements or cause the joint to lock, and in some cases, can destroy the normal joint structure.  the knee is most commonly affected by this condition, though it can occur in other joints such as the hip, shoulder, elbow, ankle, or wrist.  the average age of diagnosis for this condition is 35 years. last updated: 11/28/2011

MalaCards based summary: Pigmented Villonodular Synovitis, also known as localized pigmented villonodular synovitis, is related to synovitis and giant cell tumor. An important gene associated with Pigmented Villonodular Synovitis is IBSP (integrin-binding sialoprotein), and among its related pathways are Syndecan-1-mediated signaling events and Osteopontin Signaling. The compounds pyridinoline and ibandronate have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and testes, and related mouse phenotypes are craniofacial and limbs/digits/tail.

Wikipedia:63 Pigmented villonodular synovitis (PVNS) is a joint disease characterized by inflammation and overgrowth... more...

Related Diseases for Pigmented Villonodular Synovitis

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Diseases related to Pigmented Villonodular Synovitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 129)
idRelated DiseaseScoreTop Affiliating Genes
1synovitis32.8CD68, MMP1, TNFRSF11B, TNFSF11
2giant cell tumor31.6TNFSF11, CSF1R, CSF1
3osteonecrosis31.5BGLAP
4arthritis30.2BGLAP, TNFSF11, TNFRSF11B, MMP9, MMP1, ACP5
5rheumatoid arthritis29.9TNFSF11, IBSP, BGLAP, SPP1, TNFRSF11B, MMP9
6osteoarthritis28.8MMP1, MMP9, PTHLH, TNFRSF11B, TNFSF11, IBSP
7melanoma28.4SPP1, IBSP, TNFSF11, TNFRSF11B, MMP9, MMP1
8villonodular synovitis11.7
9tenosynovial giant cell tumor10.8
10multicentric reticulohistiocytosis10.6CD68
11histiocytosis10.6CD68
12malignant giant cell tumor10.6
13neuropathy10.6
14tuberculosis10.6
15testicular germ cell tumor10.6
16camurati-engelmann disease10.5BGLAP
17hemarthrosis10.5
18sarcoma10.5
19synovial chondromatosis10.5
20cherubism10.5TNFSF11
21periapical granuloma10.4TNFSF11
22pseudohypoparathyroidism, type ib10.4PTHLH, BGLAP
23osteopetrosis, autosomal dominant 210.4BGLAP, TNFSF11
24paget disease, juvenile10.4TNFSF11, TNFRSF11B
25osteolysis, familial expansile10.4TNFSF11, TNFRSF11B
26fibrous dysplasia10.4IBSP, BGLAP
27pseudohypoparathyroidism10.4PTHLH, BGLAP
28hyperostosis, endosteal10.4TNFRSF11B, TNFSF11
29osteomyelitis10.4IBSP, TNFSF11, ACP5
30dentin dysplasia10.3SPP1, IBSP
31nephrolithiasis10.3IBSP, SPP1
32neurofibromatosis10.3
33renal osteodystrophy10.3BGLAP, TNFRSF11B, ACP5
34systemic lupus erythematosus10.3
35lipoma10.3
36hemangioma10.3
37nodular tenosynovitis10.3
38malignant giant cell tumor of the tendon sheath10.3
39chondroblastoma10.3
40peroneal neuropathy10.3
41ulnar neuropathy10.3
42bone giant cell tumor10.3
43cervicitis10.3
44conjunctivitis10.3
45epithelioid sarcoma10.3
46lupus erythematosus10.3
47paraplegia10.3
48spondylitis10.3
49noonan-like/multiple giant cell lesion syndrome10.3
50soft tissue sarcoma10.3

Graphical network of the top 20 diseases related to Pigmented Villonodular Synovitis:



Diseases related to pigmented villonodular synovitis

Symptoms for Pigmented Villonodular Synovitis

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Drugs & Therapeutics for Pigmented Villonodular Synovitis

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Drug clinical trials:

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Genetic Tests for Pigmented Villonodular Synovitis

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Anatomical Context for Pigmented Villonodular Synovitis

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MalaCards organs/tissues related to Pigmented Villonodular Synovitis:

31
Bone, Lung, Testes

Animal Models for Pigmented Villonodular Synovitis or affiliated genes

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Publications for Pigmented Villonodular Synovitis

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Articles related to Pigmented Villonodular Synovitis:

(show top 50)    (show all 528)
idTitleAuthorsYear
1
Computed Tomography and Magnetic Resonance Manifestations of Spinal Pigmented Villonodular Synovitis. (25836023)
2015
2
Postoperative radiotherapy for diffuse pigmented villonodular synovitis of the temporomandibular joint. (25459320)
2015
3
Transtrochanteric rotational osteotomy combined with intra-articular procedures for pigmented villonodular synovitis of the hip. (24687213)
2014
4
Unusual cases of pigmented villonodular synovitis after arthroplasty. (24955198)
2014
5
Pigmented villonodular synovitis diagnostic delay due to coexistence with ankylosing spondylitis. (24642231)
2014
6
Low-dose external beam radiotherapy as a postoperative treatment for patients with diffuse pigmented villonodular synovitis of the knee: 4 recurrences in 23 patients followed for mean 9 years. (22489888)
2012
7
Hip joint pigmented villonodular synovitis in a young girl: a case report. (22433958)
2012
8
Pigmented villonodular synovitis of the ankle presenting as a persisting ankle effusion. (22764668)
2012
9
The management of diffuse-type giant cell tumour (pigmented villonodular synovitis) and giant cell tumour of tendon sheath (nodular tenosynovitis). (22733940)
2012
10
One step open synovectomy without adjuvant therapy for diffuse pigmented villonodular synovitis of the knee in a soccer player. (23738243)
2011
11
Destructive synovial hemangioma of the hip resembling pigmented villonodular synovitis. (20570091)
2011
12
Pigmented villonodular synovitis of the temporomandibular joint: case report and review of the literature. (21310347)
2011
13
Radiation therapy for treatment of pigmented villonodular synovitis: results of a national patterns of care study. (20488628)
2010
14
Arthroscopic treatment of pigmented villonodular synovitis involving bilateral shoulders. (20806759)
2010
15
Tenosynovial giant cell tumor and pigmented villonodular synovitis: a proposal for unification of these clinically distinct but histologically and genetically identical lesions. (17225151)
2007
16
Pigmented villonodular synovitis of the elbow in a 6-year-old girl: a case report. (17429130)
2007
17
Radial and ulnar neuropathy due to pigmented villonodular synovitis of the elbow. (17126239)
2006
18
Pigmented villonodular synovitis. (16311109)
2006
19
Similarities between giant cell tumor of bone, giant cell tumor of tendon sheath, and pigmented villonodular synovitis concerning ultrastructural cytochemical features of multinucleated giant cells and mononuclear stromal cells. (16825116)
2006
20
Clustered localized pigmented villonodular synovitis. (15944639)
2005
21
Pigmented villonodular synovitis of the knee: disease of the popliteus tendon and posterolateral compartment. (16012505)
2005
22
Pigmented villonodular synovitis: a disease in evolution. (15290750)
2004
23
Incidental detection of pigmented villonodular synovitis on FDG PET. (12897655)
2003
24
Pigmented villonodular synovitis of the anserine bursa. (12817733)
2003
25
Pigmented villonodular synovitis of the knee presenting as sciatica. (12943290)
2003
26
Tuberculosis of the hip as the presenting sign of HIV and simulating pigmented villonodular synovitis. (12107577)
2002
27
Langerhans cell granulomatosis manifested as pigmented villonodular synovitis. (12132822)
2001
28
Arthroscopic treatment of pigmented villonodular synovitis of the shoulder. (11154374)
2001
29
Giant cell tumor of tendon sheath, tenosynovial giant cell tumor, and pigmented villonodular synovitis: defining the presentation, surgical therapy and recurrence. (10671695)
2000
30
Dynamic MR-imaging in the diagnosis of pigmented villonodular synovitis of the knee. (11093605)
2000
31
Magnetic resonance imaging evaluation and arthroscopic resection of localized pigmented villonodular synovitis of the knee. (10791586)
2000
32
Lipoma induced by pigmented villonodular synovitis of the ankle. (10359296)
1999
33
An unusual case of pigmented villonodular synovitis of the spine: benign aggressive and/or malignant? (10371292)
1999
34
Pigmented villonodular synovitis of the foot and ankle: a review of six cases. (10353773)
1999
35
Pigmented villonodular synovitis and related lesions: the spectrum of imaging findings. (9888766)
1999
36
Cytokine and matrix metalloproteinase expression in pigmented villonodular synovitis may mediate bone and cartilage destruction. (9807705)
1998
37
Diffuse pigmented villonodular synovitis of the knee associated with chronic ACL deficiency. (9606698)
1998
38
Total knee arthroplasty in patients who have pigmented villonodular synovitis. (9469312)
1998
39
Articular pigmented villonodular synovitis of the MP joint of the hand. (8543887)
1995
40
Diagnostic features of diffuse pigmented villonodular synovitis of the knee. (8118978)
1994
41
Pigmented villonodular synovitis of the temporomandibular joint. (8228609)
1993
42
Evaluation of the hip with pigmented villonodular synovitis. A case report. (1735210)
1992
43
Case report 578: Pigmented villonodular synovitis of the shoulder. (2321043)
1990
44
Pigmented villonodular synovitis in a vertebra. A case report. (2365726)
1990
45
Diffuse pigmented villonodular synovitis of the temporomandibular joint diagnosed by fine-needle aspiration cytology. (2791838)
1989
46
Case report 563: Pigmented villonodular synovitis (PVNS) of knee. (2814557)
1989
47
Pigmented villonodular synovitis of the knee: results from 13 cases. (2706054)
1989
48
A case of aggressive pigmented villonodular synovitis. (3421087)
1988
49
Pigmented villonodular synovitis of the hip--association with osteochondromatosis. (3440329)
1987
50
Pigmented villonodular synovitis of the temporomandibular joint: a case report. (10994414)
1982

Variations for Pigmented Villonodular Synovitis

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Expression for genes affiliated with Pigmented Villonodular Synovitis

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Search GEO for disease gene expression data for Pigmented Villonodular Synovitis.

Pathways for genes affiliated with Pigmented Villonodular Synovitis

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Pathways related to Pigmented Villonodular Synovitis according to GeneCards Suite gene sharing:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9MMP1, MMP9
29.9MMP9, SPP1
3
Show member pathways
RANKL/RANK Signaling Pathway36
Apoptosis and survival APRIL and BAFF signaling58
9.8TNFRSF11B, ACP5, TNFSF11
49.7CSF1, CD68
5
Show member pathways
Apoptosis and survival TNFR1 signaling pathway58
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
9.7TNFSF11, MMP9, TNFRSF11B
69.7MMP1, MMP9, BGLAP
79.7PTHLH, MMP9, SPP1
89.6SPP1, MMP9, BGLAP
99.5SPP1, CSF1, CSF1R
109.5SPP1, TNFRSF11B, TNFSF11, ACP5
119.5BGLAP, SPP1, TNFRSF11B, TNFSF11
129.5PDGFRB, CSF1, CSF1R
139.5CSF1R, PDGFRB, CSF1
149.4TNFRSF11B, TNFSF11, IBSP, PDGFRB
15
Show member pathways
9.4IBSP, SPP1, MMP9, MMP1
169.3LAPTM5, ACP5, CD68
179.3PTHLH, TNFSF11, IBSP, BGLAP, SPP1
189.2CSF1R, MMP1, MMP9, PDGFRB
199.1TNFSF11, TNFRSF11B, ACP5, CSF1R, CSF1
209.0CSF1, CSF1R, IBSP, PDGFRB, SPP1
21
Show member pathways
9.0TNFSF11, PDGFRB, CSF1, CSF1R, TNFRSF11B
22
Show member pathways
8.9CSF1, PDGFRB, CSF1R, TNFSF11, SPP1
238.6CSF1, ATP6V1B2, TNFSF11, MMP1, ACP5

Compounds for genes affiliated with Pigmented Villonodular Synovitis

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Compounds related to Pigmented Villonodular Synovitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 174)
idCompoundScoreTop Affiliating Genes
1pyridinoline4310.6TNFRSF11B
2ibandronate43 1210.8TNFRSF11B, IBSP, BGLAP, TNFSF11
3deoxypyridinoline439.7TNFSF11, IBSP, ACP5, BGLAP, TNFRSF11B
4pamidronate43 49 1211.6BGLAP, TNFSF11, TNFRSF11B, PTHLH, MMP1
5tartrate439.6CSF1, PTHLH, TNFSF11, BGLAP, ACP5
6alendronate43 49 1211.6PTHLH, TNFRSF11B, TNFSF11, MMP1, BGLAP
7vitamin k2439.5BGLAP, TNFSF11, TNFRSF11B, CSF1
8clodronate43 49 1211.5MMP1, TNFSF11, TNFRSF11B, PTHLH, BGLAP, ACP5
9titanium439.5SPP1, IBSP, ACP5, TNFRSF11B, TNFSF11, BGLAP
1025-hydroxyvitamin d439.4PTHLH, TNFSF11, TNFRSF11B, ACP5, BGLAP, SPP1
11phosphorus439.4BGLAP, PTHLH, SPP1, TNFSF11, ACP5, TNFRSF11B
12infliximab43 49 1211.4MMP1, TNFRSF11B, BGLAP, SPP1, TNFSF11
13hydroxyapatite439.2IBSP, TNFSF11, BGLAP, SPP1, TNFRSF11B, PTHLH
14hydroxyproline43 24 1211.2ACP5, MMP9, PTHLH, TNFRSF11B, IBSP, MMP1
15zoledronic acid439.2BGLAP, IBSP, TNFSF11, TNFRSF11B, PTHLH, MMP9
16azathioprine43 2 49 1212.1PCNA, PTHLH, TNFRSF11B, BGLAP, TNFSF11, ACP5
17geranylgeranyl pyrophosphate439.1TNFRSF11B, MMP9, MMP1, TNFSF11
18celecoxib43 59 28 49 24 1213.9TNFSF11, TNFRSF11B, MMP9, MMP1, PCNA, CSF1
19prostaglandin438.8PTHLH, MMP9, MMP1, CSF1, TNFRSF11B, TNFSF11
20tgf beta1438.8PTHLH, SPP1, TNFRSF11B, MMP1, CSF1, PDGFRB
21matrigel438.8IBSP, SPP1, PTHLH, MMP9, PDGFRB, MMP1
22rantes438.7MMP1, MMP9, TNFRSF11B, TNFSF11, CSF1, ACP5
23ns 39843 599.7BGLAP, TNFSF11, TNFRSF11B, MMP9, PCNA, MMP1
24pd 98,059438.7CSF1, CSF1R, MMP9, TNFSF11, IBSP, MMP1
25estradiol43 24 1210.7IBSP, ACP5, MMP1, TNFRSF11B, TNFSF11, PTHLH
261,25 dihydroxy vitamin d3438.6CSF1, CSF1R, ACP5, PTHLH, TNFRSF11B, TNFSF11
27nicotine43 28 49 1211.6MMP1, PTHLH, CSF1, SPP1, PCNA, MMP9
28indomethacin43 28 59 1211.6SPP1, TNFSF11, PTHLH, CSF1, TNFRSF11B, PCNA
29vitamin d438.6BGLAP, SPP1, CSF1R, TNFSF11, IBSP, PTHLH
30ascorbic acid43 249.5SPP1, CSF1, BGLAP, IBSP, TNFRSF11B, MMP1
31calcitriol43 59 24 1211.5TNFSF11, BGLAP, SPP1, TNFRSF11B, PTHLH, MMP1
32cyclosporin a43 28 5910.5TNFRSF11B, BGLAP, SPP1, TNFSF11, MMP9, MMP1
33cycloheximide438.4SPP1, MMP9, TNFRSF11B, TNFSF11, MMP1, IBSP
34procollagen438.4SPP1, BGLAP, IBSP, TNFSF11, TNFRSF11B, PCNA
35heparin43 28 24 1211.3PTHLH, BGLAP, TNFSF11, IBSP, SPP1, TNFRSF11B
36genistein43 28 59 2 24 1213.2PCNA, MMP9, SPP1, PDGFRB, TNFSF11, MMP1
37phosphatidylinositol438.2IBSP, SPP1, TNFRSF11B, PTHLH, TNFSF11, CSF1R
38h2o2438.1TNFSF11, PDGFRB, MMP1, BGLAP, SPP1, CSF1
39progesterone43 28 59 24 1212.1SPP1, TNFRSF11B, PTHLH, MMP1, CSF1R, CSF1
40pge2438.0TNFSF11, TNFRSF11B, PTHLH, MMP9, MMP1, ACP5
41creatinine437.8CSF1, PCNA, ACP5, MMP1, MMP9, PTHLH
42testosterone43 59 24 1210.8CSF1, TNFRSF11B, TNFSF11, PTHLH, MMP9, BGLAP
43tyrosine437.7CSF1, CSF1R, ACP5, MMP9, PTHLH, TNFRSF11B
44serine437.7TNFRSF11B, IBSP, BGLAP, SPP1, PTHLH, MMP9
45retinoic acid43 248.7CSF1R, PDGFRB, CSF1, PCNA, TNFRSF11B, MMP1
46dexamethasone43 49 28 1210.5CSF1, CSF1R, PCNA, ACP5, MMP1, MMP9
47vegf437.3IBSP, BGLAP, SPP1, TNFSF11, TNFRSF11B, PTHLH
48cysteine437.3CSF1R, TNFSF11, PDGFRB, TNFRSF11B, IBSP, BGLAP
49estrogen437.1IBSP, PDGFRB, CSF1, PTHLH, SPP1, BGLAP
50paraffin437.0ACP5, MMP1, MMP9, TNFSF11, IBSP, BGLAP

GO Terms for genes affiliated with Pigmented Villonodular Synovitis

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Cellular components related to Pigmented Villonodular Synovitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1membrane-bounded vesicleGO:003198810.0BGLAP, SPP1
2extracellular regionGO:00055768.4MMP1, SPP1, BGLAP, IBSP, TNFSF11, TNFRSF11B
3extracellular spaceGO:00056158.3SPP1, BGLAP, TNFSF11, TNFRSF11B, PTHLH, MMP9

Biological processes related to Pigmented Villonodular Synovitis according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1regulation of bone resorptionGO:004512410.2CSF1R, BGLAP
2osteoclast proliferationGO:000215810.1TNFSF11, CSF1
3positive regulation of bone resorptionGO:004578010.1TNFSF11, SPP1
4response to vitamin DGO:003328010.1BGLAP, SPP1
5phosphatidylinositol metabolic processGO:004648810.0PDGFRB, CSF1R
6biomineral tissue developmentGO:003121410.0IBSP, SPP1
7osteoblast developmentGO:00020769.9BGLAP, PTHLH
8osteoclast differentiationGO:00303169.9CSF1, CSF1R, TNFSF11
9positive regulation of osteoclast differentiationGO:00456729.9TNFSF11, CSF1
10extracellular matrix disassemblyGO:00226179.8SPP1, MMP9, MMP1
11macrophage differentiationGO:00302259.8MMP9, CSF1R, CSF1
12skeletal system developmentGO:00015019.7MMP9, PTHLH, TNFRSF11B, BGLAP
13bone resorptionGO:00454539.7ACP5, TNFSF11
14ossificationGO:00015039.7CSF1, MMP9, TNFSF11, IBSP
15positive regulation of cell migrationGO:00303359.6CSF1R, CSF1, PDGFRB
16extracellular matrix organizationGO:00301989.5SPP1, IBSP, TNFRSF11B, MMP9, MMP1
17phosphatidylinositol-mediated signalingGO:00480159.4PDGFRB, CSF1R, PCNA
18positive regulation of cell proliferationGO:00082849.3PTHLH, CSF1R, CSF1, PDGFRB

Molecular functions related to Pigmented Villonodular Synovitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.4CSF1, TNFRSF11B, TNFSF11, SPP1

Products for genes affiliated with Pigmented Villonodular Synovitis

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Sources for Pigmented Villonodular Synovitis

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3CDC
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25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
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46OMIM via Orphanet
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