TGCT
MCID: PGM001
MIFTS: 49

Pigmented Villonodular Synovitis (TGCT) malady

Categories: Rare diseases, Bone diseases, Reproductive diseases, Muscle diseases

Aliases & Classifications for Pigmented Villonodular Synovitis

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Sources:
11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 39MeSH, 40MESH via Orphanet, 45NCIt, 48NIH Rare Diseases, 50Novoseek, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Pigmented Villonodular Synovitis:

Name: Pigmented Villonodular Synovitis 11 48 54 13 68
Localized Pigmented Villonodular Synovitis 48
Diffuse Giant Cell Tumor of Tenosynovium 11
Diffuse Pigmented Villonodular Synovitis 48
Fibrous Histiocytoma of Tendon Sheath 68
Synovitis, Pigmented Villonodular 39
Synovitis Pigmented Villonodular 50
Tenosynovial Giant Cell Tumors 48
 
Diffuse-Type Giant Cell Tumor 54
Tenosynovial Giant Cell Tumor 54
Testicular Germ Cell Tumor 68
Villous Tenosynovitis 11
Diffuse-Type Gct 54
Tsgct 54
Tgct 54

Characteristics:

Orphanet epidemiological data:

54
pigmented villonodular synovitis:
Inheritance: Not applicable

Classifications:



External Ids:

Disease Ontology11 DOID:2702
ICD1030 M12.2
MeSH39 D013586
NCIt45 C3401
Orphanet54 ORPHA66627
MESH via Orphanet40 D013586
UMLS via Orphanet69 C0039106
ICD10 via Orphanet31 M12.2

Summaries for Pigmented Villonodular Synovitis

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NIH Rare Diseases:48 Pigmented villonodular synovitis (pvns) is a disease in which the tissue lining the joints and tendons in the body (synovium) grows abnormally. it is characterized by a noncancerous mass or tumor. there are two types of pvns: the local or nodular form (where the tumor involves the tendons that support the joint, or in one area of the joint) and the diffuse form (where the entire lining of the joint is involved). symptoms might include: pain, limitation of movement, and locking of the joint. in some cases, the normal joint structure can be destroyed. the knee is most commonly affected by this condition, though it can occur in other joints such as the hip, shoulder, elbow, ankle, wrist, and rarely the jaw. the average age of diagnosis for this condition is 35 years. the cause of pvns is unknown. treatment involves surgery to remove the tumor and damaged portions of the synovium. last updated: 4/4/2016

MalaCards based summary: Pigmented Villonodular Synovitis, also known as localized pigmented villonodular synovitis, is related to malignant giant cell tumor and testicular germ cell tumor, and has symptoms including pain An important gene associated with Pigmented Villonodular Synovitis is CSF1 (Colony Stimulating Factor 1), and among its related pathways are Signaling events mediated by PTP1B and Signaling events mediated by TCPTP. Affiliated tissues include bone, testes and lung, and related mouse phenotypes are Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance and Increased shRNA abundance (Z-score > 2).

Wikipedia:71 Pigmented villonodular synovitis (PVNS) is a joint disease characterized by inflammation and overgrowth... more...

Related Diseases for Pigmented Villonodular Synovitis

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Diseases related to Pigmented Villonodular Synovitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1malignant giant cell tumor28.5ACP5, CALCR, CSF1, CSF1R, MMP9, PTPN11
2testicular germ cell tumor11.9
3villonodular synovitis11.9
4noonan syndrome 111.8
5synovitis11.3
6giant cell tumor10.6
7tenosynovial giant cell tumor10.5
8arthritis10.3
9rheumatoid arthritis10.3
10microcephaly 10, primary, autosomal recessive10.2ACP5, TNFSF11
11maroteaux stanescu cousin syndrome10.2ACP5, TNFSF11
12corneal staphyloma10.2ACP5, MMP9
13bronchus cancer10.2ACP5, TNFSF11
14plasma protein metabolism disease10.2CSF1, TNFSF11
15cutis laxa10.2CSF1, CSF1R
16osteonecrosis10.2
17sarcoma10.2
18tuberculosis10.2
19neuropathy10.2
20synovial chondromatosis10.2
21spastic hemiplegia10.2MMP9, TNFSF11
22impotence10.2CSF1, TNFSF11
23myofascial pain syndrome10.1ACP5, CALCR
24acrorenal syndrome10.1ACP5, TNFSF11
25adducted thumbs dundar type10.1CSF1, CSF1R
26diplegia of upper limb10.1CSF1, CSF1R
27bulbomembranous urethral cancer10.1ACP5, MMP9, TNFSF11
28brain meningioma10.1MMP9, TP53
29bladder papillary transitional cell neoplasm10.1ACP5, CSF1, TNFSF11
30acantholytic squamous cell skin carcinoma10.1CSF1R, TP53
31wolf-hirschhorn syndrome10.1PTPN11, TNFSF11
32hemarthrosis10.1
33chiasmal syndrome10.1ACP5, PTPRC
34toxic megacolon10.0MMP9, TP53
35keratoconus10.0CSF1, TNFSF11
36monostotic fibrous dysplasia10.0CSF1, CSF1R
37statin toxicity10.0MMP9, TNFSF11, TP53
38plague10.0MMP9, TNFSF11, TP53
39chromosomal disease10.0ACP5, TNFSF11
40hypotrichosis 810.0MMP9, TNFSF11, TP53
41autistic disorder10.0ACP5, MMP9, TNFSF11
42choriocarcinoma of ovary9.9PTPRC, TP53
43systemic lupus erythematosus9.9
44chediak-higashi syndrome9.9
45lipoma9.9
46hemangioma9.9
47osteoarthritis9.9
48lymphoma9.9
49squamous cell carcinoma9.9
50melanoma9.9

Graphical network of the top 20 diseases related to Pigmented Villonodular Synovitis:



Diseases related to pigmented villonodular synovitis

Symptoms & Phenotypes for Pigmented Villonodular Synovitis

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UMLS symptoms related to Pigmented Villonodular Synovitis:


pain

GenomeRNAi Phenotypes related to Pigmented Villonodular Synovitis according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00210-A8.9ACP5, CSF1R, PTPN11, PTPRC
2GR00366-A-1928.7CALCR, PTPN11, PTPRC

MGI Mouse Phenotypes related to Pigmented Villonodular Synovitis according to GeneCards Suite gene sharing:

41 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.1CSF1, CSF1R, PTPN11, TP53
2MP:00053828.8CSF1, CSF1R, PTPN11, TNFSF11, TP53
3MP:00053918.4CSF1, MMP9, PTPN11, TNFSF11, TP53
4MP:00053698.3CSF1, MMP9, PTPN11, TNFSF11, TP53
5MP:00053898.2CSF1, CSF1R, MMP9, PTPN11, TNFSF11, TP53
6MP:00020068.1MMP9, PTPN11, PTPRC, TNFSF11, TP53
7MP:00107717.9CSF1, CSF1R, MMP9, PTPN11, TNFSF11, TP53
8MP:00053717.6CALCR, CSF1, CSF1R, MMP9, PTPN11, TNFSF11
9MP:00053797.6CSF1, CSF1R, PTPN11, PTPRC, TNFSF11, TP53
10MP:00028737.6CALCR, CSF1R, PTPN11, PTPRC, TNFSF11, TP53
11MP:00030127.5CSF1, CSF1R, PTPN11, PTPRC, TNFSF11, TP53
12MP:00053887.4CSF1, MMP9, PTPN11, PTPRC, TNFSF11, TP53
13MP:00053787.1CSF1, CSF1R, MMP9, PTPN11, PTPRC, TNFSF11
14MP:00053766.8CALCR, CSF1, CSF1R, MMP9, PTPN11, PTPRC
15MP:00053906.8CALCR, CSF1, CSF1R, MMP9, PTPN11, PTPRC
16MP:00107686.7CALCR, CSF1, CSF1R, MMP9, PTPN11, PTPRC
17MP:00053876.7CALCR, CSF1, CSF1R, MMP9, PTPN11, PTPRC
18MP:00053976.6CALCR, CSF1, CSF1R, MMP9, PTPN11, PTPRC

Drugs & Therapeutics for Pigmented Villonodular Synovitis

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Drugs for Pigmented Villonodular Synovitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1AntibodiesPhase 1, Phase 26394
2ImmunoglobulinsPhase 1, Phase 26394
3Grapefruit Seed ExtractNutraceuticalPhase 242
4
Paclitaxelapproved, vet_approvedPhase 1286433069-62-436314
Synonyms:
(2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester
12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
157069-30-2
33069-62-4
5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxete,benzenepropanoic acid deriv.
7-Epi-Paclitaxel
7-Epi-Taxol
7-Epipaclitaxel
7-Epitaxol
7-epi-Paclitaxel
7-epi-Taxol
AB00513812
ABI 007
ABI-007
ABI007
AC-675
AC1L1IOG
AC1L1VJI
AC1L9AVF
ACon1_002231
ANX-513
Abraxane
Abraxane (TN)
Abraxane I.V. Suspension
Abraxis BioScience brand of albumin-bound paclitaxel
Ambotz33069-62-4
Anzatax
Asotax
BIDD:PXR0046
BMS 181339-01
BMS-181339
BMS-181339-01
BPBio1_000320
BRD-A23723433-001-01-2
BRD-A28746609-001-04-0
BRD-K62008436-001-03-1
BSPBio_000290
BSPBio_001152
BSPBio_002614
Bio-0076
Bio1_000362
Bio1_000851
Bio1_001340
Bio2_000416
Bio2_000896
Bristaxol
C07394
C466458
C47H51NO14
CCRIS 8143
CHEBI:103439
CHEBI:45863
CHEMBL100910
CHEMBL418410
CHEMBL48
CID36314
CID441276
CID4666
CID6713921
CID6915727
CPD-8718
Capxol
D00491
DB01229
DHP-107
DHP-208
DRG-0190
DTS-301
DivK1c_000441
EU-0101201
Ebetaxel
EmPAC
Epitaxol
Genaxol
Genetaxyl
Genexol
Genexol-PM
HMS1362J13
HMS1568O12
HMS1792J13
HMS1922K08
HMS1990J13
HMS2090D07
HMS2093K15
HMS501G03
HSDB 6839
I06-0014
IDI1_000441
IDI1_002171
Intaxel
KBio1_000441
KBio2_000492
KBio2_002016
KBio2_002509
KBio2_003060
KBio2_004584
KBio2_005077
KBio2_005628
KBio2_007152
KBio2_007645
KBio3_000903
KBio3_000904
KBio3_001834
KBio3_002987
KBioGR_000492
KBioGR_001893
 
KBioGR_002509
KBioSS_000492
KBioSS_002016
KBioSS_002517
LMPR0104390001
LS-31070
LipoPac
Lopac0_001201
MBT 0206
MEGxp0_001940
MLS000863266
MLS001077297
MLS002154218
MLS002172439
MLS002695976
MPI-5018
Micellar Paclitaxel
Mitotax
MolPort-001-742-627
MolPort-003-665-783
MolPort-003-932-365
NCGC00024995-02
NCGC00024995-03
NCGC00024995-04
NCGC00024995-05
NCGC00024995-06
NCGC00024995-07
NCGC00164367-01
NCGC00164367-02
NCGC00164367-03
NCI60_000601
NINDS_000441
NK 105
NP-010981
NSC 125973
NSC-125973
NSC125973
NSC358882
Nanotaxel
Neuro_000060
Nova-12005
OAS-PAC-100
OncoGel
Onxal
Onxol
Onxol, Taxol, Nov-Onxol, Paclitaxel
P1632
Paclical
Pacligel
Paclitaxel
Paclitaxel (JAN/USP)
Paclitaxel (JAN/USP/INN)
Paclitaxel (Taxol)
Paclitaxel [USAN:INN:BAN]
Paxceed
Paxene
Paxoral
Plaxicel
Praxel
Prestwick0_000155
Prestwick1_000155
Prestwick2_000155
Prestwick3_000155
Probes2_000350
QW 8184
S-8184 Paclitaxel Injectable Emulsion
S1150_Selleck
SDCCGMLS-0066823.P001
SDP-013
SMP1_000228
SMR000394086
SMR000857385
SPBio_000943
SPBio_002229
SPECTRUM1503908
ST50306996
Spectrum2_000872
Spectrum3_001057
Spectrum4_001197
Spectrum5_001491
Spectrum_001536
T 7402
T1912_SIGMA
T7191_SIGMA
T7402_SIGMA
TA1
TAXOL (TN)
TAXOL, 10-EPI,
TXL
TaxAlbin
Taxol
Taxol A
Taxol Konzentrat
Taxol.RTM. (Registered Trademark)
UNII-P88XT4IS4D
UPCMLD-DP108:001
UPCMLD-DP108:002
Vascular Wrap
Xorane
Yewtaxan
abi-007
albumin-bound paclitaxel
cMAP_000068
nab-paclitaxel
nchembio.188-comp1
nchembio.2007.34-comp9
nchembio.215-comp9
nchembio853-comp6
paclitaxel
weekly paclitaxel
5Antineoplastic Agents, PhytogenicPhase 15602
6Albumin-Bound PaclitaxelPhase 12864
7Antimitotic AgentsPhase 15657

Interventional clinical trials:

idNameStatusNCT IDPhase
1PLX3397 Phase 3 Study for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS)Active, not recruitingNCT02371369Phase 3
2Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT)CompletedNCT01261429Phase 2
3MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCTTS)RecruitingNCT01643850Phase 2
4Study of FPA008 in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell TumorRecruitingNCT02471716Phase 1, Phase 2
5Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell TumorActive, not recruitingNCT01207492Phase 2
6A Study of PLX73086 in Advanced Solid Tumors and Locally Advanced or Refractory Tenosynovial Giant Cell TumorRecruitingNCT02673736Phase 1
7Phase 1 Study of PLX7486 as Single Agent in Patients With Advanced Solid TumorsRecruitingNCT01804530Phase 1
8A Study of RO5509554 as Monotherapy and in Combination With Paclitaxel in Participants With Advanced Solid TumorsActive, not recruitingNCT01494688Phase 1
9Tenosynovial Giant Cell Tumors (TGCT) Observational Platform ProjectRecruitingNCT02948088

Search NIH Clinical Center for Pigmented Villonodular Synovitis


Cochrane evidence based reviews: synovitis, pigmented villonodular

Genetic Tests for Pigmented Villonodular Synovitis

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Anatomical Context for Pigmented Villonodular Synovitis

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MalaCards organs/tissues related to Pigmented Villonodular Synovitis:

36
Bone, Testes, Lung

Publications for Pigmented Villonodular Synovitis

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Articles related to Pigmented Villonodular Synovitis:

(show top 50)    (show all 570)
idTitleAuthorsYear
1
Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis). (28057477)
2017
2
Osteonecrosis of the femoral head associated with pigmented villonodular synovitis. (27928593)
2016
3
Pigmented villonodular synovitis of the knee joint in a 5-year-old girl treated with combined open and arthroscopic surgery: a case report. (26919624)
2016
4
Pigmented villonodular synovitis: a crowdsourcing study of two hundred and seventy two patients. (27169531)
2016
5
Pigmented villonodular synovitis of proximal tibiofibular joint: Rare site of involvement treated with medical management. (28032093)
2016
6
Locked hip joint: an uncommon presentation of localized pigmented villonodular synovitis. (27130398)
2016
7
Organ-specific radiation-induced cancer risk estimates due to radiotherapy for benign pigmented villonodular synovitis. (27499236)
2016
8
Pigmented Villonodular Synovitis of the Knee Joint: A Case Report. (27843734)
2016
9
Arthroscopic surgical treatment of pigmented villonodular synovitis of the elbow: case report. (27517031)
2016
10
Tumorlike Pigmented Villonodular Synovitis With Atypical Location: Appearance on 3-Phase 99mTc-MDP Bone Scan. (28005642)
2016
11
Current Systemic Treatment Options for Tenosynovial Giant Cell Tumor/Pigmented Villonodular Synovitis: Targeting the CSF1/CSF1R Axis. (26820289)
2016
12
Pigmented villonodular synovitis mimics metastases on fluorine 18 fluorodeoxyglucose position emission tomography-computed tomography. (27190776)
2016
13
Pigmented villonodular synovitis diagnosed during revision total knee arthroplasty for flexion instability and patellar fracture. (26810732)
2016
14
Pigmented Villonodular Synovitis: A Comprehensive Review and Proposed Treatment Algorithm. (27509331)
2016
15
Pigmented Villonodular Synovitis of the Hip: A Systematic Review. (26761914)
2016
16
Multifocal pigmented villonodular synovitis in a child: A case report. (27537585)
2016
17
A systematic literature review of synovial chondromatosis and pigmented villonodular synovitis of the hip. (27462929)
2016
18
Arthroscopically-assisted mini open partial synovectomy for the treatment of localized pigmented villonodular synovitis of the knee. A retrospective comparative study with long-term follow up. (27866235)
2016
19
Pigmented Villonodular Synovitis of the Temporomandibular Joint: A Unique Presentation. (27200236)
2016
20
Case report of pigmented villonodular synovitis arising from the calcaneocuboid joint in a 12 year old male. (25510167)
2015
21
Tenosynovial giant cell tumour/pigmented villonodular synovitis: outcome of 294 patients before the era of kinase inhibitors. (25465190)
2015
22
Acute Knee Pain in a Child Due to Pigmented Villonodular Synovitis. (27299078)
2015
23
A severe systemic presentation of pigmented villonodular synovitis in a child with underlying Chediak-Higashi syndrome. (25967956)
2015
24
Pigmented Villonodular Synovitis Presenting as a Popliteal Cyst. (27299073)
2015
25
Use of yttrium-90 hydroxyapatite radiosynovectomy as a primary modality of treatment in diffuse pigmented villonodular synovitis of the knee joint: A first case report. (25589806)
2015
26
Arthroscopic Synovectomy and Postoperative Assisted Radiotherapy for Treating Diffuse Pigmented Villonodular Synovitis of the Knee: An observational retrospective study. (26430437)
2015
27
Pigmented Villonodular Synovitis: Potential Pitfall on Oncologic 18F-FDG PET/CT. (26164181)
2015
28
Computed Tomography and Magnetic Resonance Manifestations of Spinal Pigmented Villonodular Synovitis. (25836023)
2015
29
Tenosynovial Giant Cell Tumor, Diffuse Type/Pigmented Villonodular Synovitis in a Pars Defect: A Case Report. (26067150)
2015
30
Arthroscopic T-capsulotomy for Excision of Pigmented Villonodular Synovitis in the Hip. (25901612)
2015
31
Recurrent pigmented villonodular synovitis and multifocal giant cell tumor of the tendon sheath: case report. (25577961)
2015
32
Surgical outcomes after excision of pigmented villonodular synovitis localized to the ankle and hindfoot without adjuvant therapy. (25618808)
2015
33
Intra-Articular Synovial Sarcomas: Incidence and Differentiating Features from Localized Pigmented Villonodular Synovitis. (26819567)
2015
34
Tenosynovial giant cell tumour (pigmented villonodular synovitis-)-like changes in periprosthetic interface membranes. (26553457)
2015
35
Intra-articular post-traumatic ankle joint mass imitating localized pigmented villonodular synovitis (LPVS), the aid of ankle arthroscopy for diagnosis and treatment-A case report. (25637030)
2015
36
Expression of colony-stimulating factor 1 is associated with occurrence of osteochondral change in pigmented villonodular synovitis. (25854167)
2015
37
Surgical treatment of diffuse pigmented villonodular synovitis of the knee. (25936715)
2015
38
Primary synovial epithelioid sarcoma of the knee: distinctly unusual location leading to its confusion with pigmented villonodular synovitis. (25801084)
2015
39
MRI and thallium features of pigmented villonodular synovitis and giant cell tumours of tendon sheaths: a retrospective single centre study of imaging and literature review. (26440548)
2015
40
Pigmented villonodular synovitis of temporomandibular joint: pathological aspects and surgical treatment. (25937582)
2015
41
Postoperative radiotherapy for diffuse pigmented villonodular synovitis of the temporomandibular joint. (25459320)
2015
42
The effect of surgical synovectomy and radiotherapy on the rate of recurrence of pigmented villonodular synovitis of the knee: an individual patient meta-analysis. (25820897)
2015
43
Dual-energy computed tomography molecular imaging of pigmented villonodular synovitis. (25504960)
2015
44
Pigmented Villonodular Synovitis: a recurrent case with atypical location and extra-articular extension. (26219971)
2015
45
Bilateral pigmented villonodular synovitis of the knee. (26649121)
2015
46
Pigmented villonodular synovitis of the temporomandibular joint: Case report and review of literature. (25821131)
2015
47
Metastasizing tenosynovial giant cell tumour, diffuse type/pigmented villonodular synovitis. (26052431)
2015
48
Pigmented villonodular synovitis of the temporomandibular joint with intracranial extension. (25699525)
2015
49
Multi-lineage differentiation and angiogenesis potentials of pigmented villonodular synovitis derived mesenchymal stem cells - pathological implication. (26291329)
2015
50
Pigmented villonodular synovitis: a retrospective multicenter study of 237 cases. (25799575)
2015

Variations for Pigmented Villonodular Synovitis

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Expression for genes affiliated with Pigmented Villonodular Synovitis

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Search GEO for disease gene expression data for Pigmented Villonodular Synovitis.

Pathways for genes affiliated with Pigmented Villonodular Synovitis

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Pathways related to Pigmented Villonodular Synovitis according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathwaysScoreTop Affiliating Genes
19.8CSF1, CSF1R
2
Show member pathways
9.8CSF1, CSF1R
39.6ACP5, TNFSF11
49.6CALCR, TNFSF11
59.4MMP9, PTPN11
69.4CSF1, CSF1R, TNFSF11
79.3PTPN11, TP53
89.3ACP5, CSF1, TNFSF11
99.3CSF1, CSF1R, PTPN11
10
Show member pathways
9.2ACP5, CALCR, TNFSF11
119.1MMP9, PTPRC
129.1PTPN11, PTPRC
139.0CSF1R, MMP9, TP53
149.0CSF1, CSF1R, PTPRC
15
Show member pathways
8.9PTPN11, TNFSF11, TP53
168.8MMP9, PTPN11, TP53
17
Show member pathways
8.8CSF1R, PTPN11, PTPRC
188.6MMP9, PTPN11, PTPRC
198.6ACP5, CALCR, CSF1, CSF1R, TNFSF11
20
Show member pathways
8.0CSF1, CSF1R, PTPN11, PTPRC, TNFSF11
21
Show member pathways
7.7CSF1, CSF1R, MMP9, PTPN11, TNFSF11, TP53
22
Show member pathways
6.9CSF1, CSF1R, MMP9, PTPN11, PTPRC, TNFSF11

GO Terms for genes affiliated with Pigmented Villonodular Synovitis

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Cellular components related to Pigmented Villonodular Synovitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1CSF1-CSF1R complexGO:19906829.8CSF1, CSF1R

Biological processes related to Pigmented Villonodular Synovitis according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1macrophage colony-stimulating factor signaling pathwayGO:003814510.5CSF1, CSF1R
2osteoclast proliferationGO:000215810.3CSF1, TNFSF11
3bone resorptionGO:004545310.3ACP5, TNFSF11
4homeostasis of number of cells within a tissueGO:004887310.3CSF1, PTPN11
5positive regulation of osteoclast differentiationGO:004567210.2CSF1, TNFSF11
6macrophage differentiationGO:00302259.9CSF1, CSF1R, MMP9
7positive regulation of cell migrationGO:00303359.8CSF1, CSF1R, MMP9
8positive regulation of release of cytochrome c from mitochondriaGO:00902009.7MMP9, TP53
9phosphatidylinositol-mediated signalingGO:00480159.6CSF1R, PTPN11, TP53
10osteoclast differentiationGO:00303169.6CALCR, CSF1, CSF1R, TNFSF11
11dephosphorylationGO:00163119.4ACP5, PTPN11, PTPRC
12response to gamma radiationGO:00103329.0PTPRC, TP53

Molecular functions related to Pigmented Villonodular Synovitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor tyrosine kinase bindingGO:00309719.3PTPN11, TP53

Sources for Pigmented Villonodular Synovitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
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50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet