MCID: PGM001
MIFTS: 57

Pigmented Villonodular Synovitis malady

Bone diseases, Muscle diseases, Cancer diseases categories

Summaries for Pigmented Villonodular Synovitis

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Pigmented villonodular synovitis is a disease in which the tissue lining a joint in the body begins to grow abnormally.  there are two types of pigmented villonodular synovitis: the nodular form (where the abnormal tissue growth forms a single bump) and the diffuse form (where the entire lining of the joint grows unusually).  the additional tissue in the joint can cause pain, limit movements or cause the joint to lock, and in some cases, can destroy the normal joint structure.  the knee is most commonly affected by this condition, though it can occur in other joints such as the hip, shoulder, elbow, ankle, or wrist.  the average age of diagnosis for this condition is 35 years. last updated: 11/28/2011

MalaCards: Pigmented Villonodular Synovitis, also known as localized pigmented villonodular synovitis, is related to synovitis and giant cell tumor. An important gene associated with Pigmented Villonodular Synovitis is ACP5 (acid phosphatase 5, tartrate resistant), and among its related pathways are Osteopontin Signaling and Integrins in angiogenesis. The compounds pge2 and procollagen have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and lung, and related mouse phenotypes are limbs/digits/tail and integument.

Wikipedia:63 Pigmented villonodular synovitis (PVNS) is a joint disease characterized by inflammation and overgrowth... more...

Aliases & Classifications for Pigmented Villonodular Synovitis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Bone diseases, Muscle diseases


Aliases & Descriptions:

pigmented villonodular synovitis 8 42 10 48 60
localized pigmented villonodular synovitis 42
diffuse giant cell tumor of tenosynovium 8
diffuse pigmented villonodular synovitis 42
fibrous histiocytoma of tendon sheath 60
synovitis pigmented villonodular 44
tenosynovial giant cell tumors 42
villous tenosynovitis 8


External Ids:

Disease Ontology8 DOID:2702
MeSH34 D013586
NCIt39 C3401
MESH via Orphanet35 D013586
SNOMED-CT via Orphanet57 95412009
UMLS via Orphanet61 C0039106

Related Diseases for Pigmented Villonodular Synovitis

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17GeneCards, 18GeneDecks
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Diseases related to Pigmented Villonodular Synovitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1synovitis32.4MMP1, CD68, TNFRSF11B, TNFSF11
2giant cell tumor31.3BGLAP, CSF1, TNFSF11, TNFRSF11B, MMP9
3arthritis30.9TNFRSF11B, TNFSF11, CSF1, CSF1R, BGLAP, MMP1
4rheumatoid arthritis30.9BGLAP, IBSP, CSF1, TNFSF11, TNFRSF11B, CD68
5osteonecrosis30.6BGLAP
6sarcoma30.4PDGFRB, CSF1R, CSF1
7squamous cell carcinoma30.4IBSP, CSF1R, MMP1, MMP9, PTHLH, SPP1
8melanoma30.3IBSP, PDGFRB, CSF1R, CSF1, TNFSF11, TNFRSF11B
9osteoarthritis30.3TNFSF11, CSF1, CSF1R, IBSP, BGLAP, TNFRSF11B
10villonodular synovitis11.6
11tenosynovial giant cell tumor10.7
12pigmentation disease10.6
13malignant giant cell tumor10.6
14neuropathy10.5
15noonan syndrome10.4
16carpal tunnel syndrome10.4
17hemarthrosis10.4
18tuberculosis10.4
19neurofibromatosis10.3
20chondroblastoma10.3
21nodular tenosynovitis10.3
22malignant giant cell tumor of the tendon sheath10.3
23ulnar neuropathy10.3
24systemic lupus erythematosus10.3
25paget's disease of bone10.3
26reactive arthritis10.3
27peroneal neuropathy10.3
28bone giant cell tumor10.3
29cervicitis10.3
30conjunctivitis10.3
31hemangioma10.3
32lipoma10.3
33lupus erythematosus10.3
34paraplegia10.3
35radial neuropathy10.3
36multicentric reticulohistiocytosis10.0CD68
37histiocytosis10.0CD68
38adenoma10.0PVR
39adult t-cell leukemia10.0PTHLH
40root resorption10.0TNFRSF11B
41endometriosis10.0MMP1
42glomerulonephritis10.0SPP1
43cystic fibrosis10.0TNFRSF11B
44arteriosclerosis10.0SPP1
45myelofibrosis10.0PDGFRB
46leiomyosarcoma10.0PDGFRB
47hypertension10.0MMP9
48gastrointestinal stromal tumor10.0PDGFRB
49multiple myeloma10.0TNFRSF11B, TNFSF11
50uterine sarcoma10.0PDGFRB

Graphical network of the top 20 diseases related to Pigmented Villonodular Synovitis:



Diseases related to pigmented villonodular synovitis

Clinical Features for Pigmented Villonodular Synovitis

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Drugs & Therapeutics for Pigmented Villonodular Synovitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Pigmented Villonodular Synovitis

Genetic Tests for Pigmented Villonodular Synovitis

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Anatomical Context for Pigmented Villonodular Synovitis

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32MalaCards
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MalaCards organs/tissues related to Pigmented Villonodular Synovitis:

32
Bone, Testes, Lung

Animal Models for Pigmented Villonodular Synovitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pigmented Villonodular Synovitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.8CSF1R, ACP5, CSF1
2MP:00107719.2CSF1R, TNFSF11, MMP9, SPP1
3MP:00053829.0CSF1R, PDGFRB, PTHLH, TNFSF11, TNFRSF11B, CSF1
4MP:00053908.2CALCR, IBSP, CSF1R, CSF1, TNFSF11, TNFRSF11B
5MP:00053767.7CSF1, CSF1R, PDGFRB, CALCR, PVR, TNFSF11
6MP:00053977.4TNFRSF11B, TNFSF11, CSF1, CSF1R, PDGFRB, CALCR
7MP:00053877.1TNFRSF11B, TNFSF11, CSF1, CSF1R, PDGFRB, PVR

Publications for Pigmented Villonodular Synovitis

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50PubMed
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Articles related to Pigmented Villonodular Synovitis:

(show top 50)    (show all 496)
idTitleAuthorsYear
1
Pigmented villonodular synovitis of the ankle: an anterior-posterior technique for excision. (22134437)
2013
2
Pigmented villonodular synovitis of the ankle presenting as a persisting ankle effusion. (22764668)
2012
3
Osteochondral destruction in pigmented villonodular synovitis during the clinical course. (22174203)
2012
4
Pigmented villonodular synovitis: a retrospective single-center study of 122 cases and review of the literature. (20884045)
2011
5
Osteoclast formation and function in pigmented villonodular synovitis. (21706481)
2011
6
Pigmented villonodular synovitis of the temporomandibular joint: a case report and the literature review. (21474285)
2011
7
Radiation therapy for treatment of pigmented villonodular synovitis: results of a national patterns of care study. (20488628)
2010
8
Pigmented villonodular synovitis with bicortical erosions in the thumb. (20118134)
2010
9
Treatment of diffuse pigmented villonodular synovitis of the knee with combined surgical and radiosynovectomy. (19096892)
2009
10
Arthroscopic treatment for pigmented villonodular synovitis of the shoulder associated with massive rotator cuff tear. (19560634)
2009
11
Pigmented villonodular synovitis of the elbow. (19205632)
2009
12
Radiology quiz case 2. Pigmented villonodular synovitis of the temporomandibular joint. (18347264)
2008
13
Tenosynovial giant cell tumor and pigmented villonodular synovitis: a proposal for unification of these clinically distinct but histologically and genetically identical lesions. (17225151)
2007
14
High expression level of bone degrading proteins as a possible inducer of osteolytic features in pigmented villonodular synovitis. (17601661)
2007
15
Pigmented villonodular synovitis of the foot and ankle: Forty years of experience from the Scottish bone tumor registry. (16949531)
2006
16
Pigmented villonodular synovitis of the distal radioulnar joint. (16622627)
2006
17
Pigmented villonodular synovitis. (17148989)
2006
18
What affects the recurrence and clinical outcome of pigmented villonodular synovitis? (16760805)
2006
19
Diffuse pigmented villonodular synovitis: two cases involving the calcaneocuboid joint. (15778475)
2005
20
Analysis of chromosomal imbalances by comparative genomic hybridisation of pigmented villonodular synovitis. (15766598)
2005
21
Pigmented villonodular synovitis of the temporomandibular joint: differential diagnosis of the parotid mass. (15941640)
2005
22
Subcutaneous pigmented villonodular synovitis caused by portal contamination during knee arthroscopy and open synovectomy. (15067291)
2004
23
Pigmented villonodular synovitis. (15081846)
2004
24
Pigmented villonodular synovitis of the temporomandibular joint: an extensive case with skull-base involvement. (15124172)
2004
25
Pigmented villonodular synovitis of the foot and ankle: a 12-year experience from a tertiary orthopedic Oncology Unit. (15605054)
2004
26
Imaging of pigmented villonodular synovitis. (14593562)
2003
27
Localized pigmented villonodular synovitis attached to the posterior cruciate ligament of the knee. (12861223)
2003
28
Treatment of advanced primary and recurrent diffuse pigmented villonodular synovitis of the knee. (12473708)
2002
29
Extraarticular pigmented villonodular synovitis: a cause for failed knee arthroscopy. (12439277)
2002
30
Localized pigmented villonodular synovitis: arthroscopic diagnosis and management of an "invisible" lesion. (12098113)
2002
31
Pigmented villonodular synovitis of the hip: 2- to 23-year followup study. (11451119)
2001
32
Pigmented villonodular synovitis following arthroscopic laser surgery of the knee. (11288016)
2001
33
Lipoma induced by pigmented villonodular synovitis of the ankle. (10359296)
1999
34
Pigmented villonodular synovitis of the elbow: a case report and literature review. (10194026)
1999
35
Pigmented villonodular synovitis. (9602788)
1998
36
Pigmented villonodular synovitis of the temporomandibular joint. (9394372)
1997
37
Pigmented villonodular synovitis of the ankle A case report. (24193331)
1995
38
Magnetic resonance imaging in pigmented villonodular synovitis. (8062118)
1994
39
Articular needle biopsy and pigmented villonodular synovitis. (7973414)
1993
40
Magnetic resonance imaging of pigmented villonodular synovitis in subtalar joint. Report of a case. (1395260)
1992
41
Pigmented villonodular synovitis of a lumbar facet joint. (1595436)
1992
42
Localized pigmented villonodular synovitis of the knee. Arthroscopic treatment. (1914300)
1991
43
Cytogenetic evidence of clonality in a case of pigmented villonodular synovitis. (1985707)
1991
44
Case report 563: Pigmented villonodular synovitis (PVNS) of knee. (2814557)
1989
45
Pigmented villonodular synovitis of the knee: results from 13 cases. (2706054)
1989
46
Pigmented villonodular synovitis of the shoulder. (2657682)
1989
47
Pigmented villonodular synovitis of the extensor tendon sheaths in a child. (3171302)
1988
48
Pigmented villonodular synovitis. (3597511)
1987
49
Localized pigmented villonodular synovitis of the vertebral column. (6546511)
1984
50
Characteristics of foam cells in pigmented villonodular synovitis. Immunomorphological and enzymological studies. (6474278)
1984

Genetic Variations for Pigmented Villonodular Synovitis

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Expression for genes affiliated with Pigmented Villonodular Synovitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pigmented Villonodular Synovitis

Search GEO for disease gene expression data for Pigmented Villonodular Synovitis.

Pathways for genes affiliated with Pigmented Villonodular Synovitis

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37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 29KEGG
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Compounds for genes affiliated with Pigmented Villonodular Synovitis

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Pigmented Villonodular Synovitis according to GeneCards/GeneDecks:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1pge24410.6MMP9
2procollagen4410.5TNFSF11, ACP5
3cycloheximide4410.4CSF1R, IBSP
4rantes4410.0CALCR, CSF1, ACP5
5indomethacin44 59 28 1113.0SPP1, CSF1
6estradiol44 11 2412.0IBSP, CALCR, PTHLH, ACP5
7matrigel449.9PTHLH, PDGFRB, MMP1, IBSP
8clodronate44 49 1111.9TNFSF11, MMP1, ACP5, PTHLH, TNFRSF11B
9geranylgeranyl pyrophosphate449.8TNFSF11, TNFRSF11B, MMP9, MMP1
10prostaglandin449.8TNFRSF11B, CSF1, TNFSF11, MMP1
11etanercept44 49 1111.5TNFSF11, MMP1, CSF1, TNFRSF11B
12celecoxib44 59 28 49 11 2414.5MMP1, CSF1, MMP9, TNFRSF11B, TNFSF11
13ibandronate44 1110.4TNFSF11, TNFRSF11B, IBSP, BGLAP
14pyridinoline449.3ACP5, PTHLH, TNFRSF11B, IBSP, BGLAP
15deoxypyridinoline449.2TNFSF11, BGLAP, IBSP, TNFRSF11B, ACP5
16vitamin k2449.2BGLAP, CSF1, TNFRSF11B, TNFSF11
17pamidronate44 49 1111.2MMP1, PTHLH, TNFSF11, TNFRSF11B, BGLAP
18alendronate44 49 1111.2BGLAP, MMP1, TNFRSF11B, TNFSF11, PTHLH
19tgf beta1449.1CSF1, PDGFRB, PTHLH, SPP1, MMP9, MMP1
20infliximab44 49 1111.1SPP1, MMP1, TNFRSF11B, BGLAP, TNFSF11
21titanium449.1IBSP, BGLAP, SPP1, ACP5, TNFRSF11B, TNFSF11
22pd 98,059449.0CSF1R, CSF1, TNFSF11, MMP1, IBSP, SPP1
2325-hydroxyvitamin d449.0BGLAP, TNFSF11, PTHLH, SPP1, TNFRSF11B, ACP5
24phosphorus449.0TNFSF11, PTHLH, BGLAP, SPP1, ACP5, TNFRSF11B
25azathioprine44 49 2 1112.0TNFSF11, TNFRSF11B, ACP5, PTHLH, BGLAP
26genistein44 28 59 2 11 2413.9MMP9, SPP1, TNFRSF11B, TNFSF11, MMP1, PDGFRB
27troglitazone44 28 59 1111.9MMP1, SPP1, PTHLH, MMP9, CSF1
28tartrate448.9TNFSF11, CSF1, CALCR, BGLAP, ACP5, PTHLH
29ns 39844 599.8MMP9, TNFRSF11B, TNFSF11, CSF1, BGLAP, MMP1
30hydroxyapatite448.8PTHLH, SPP1, ACP5, TNFRSF11B, TNFSF11, IBSP
31hydroxyproline44 11 2410.8MMP9, BGLAP, TNFRSF11B, ACP5, PTHLH, MMP1
32zoledronic acid448.8BGLAP, IBSP, TNFRSF11B, MMP1, PTHLH, TNFSF11
33prednisolone44 28 1110.7BGLAP, TNFRSF11B, MMP1, PTHLH, CSF1
34heparin44 28 11 2411.6IBSP, SPP1, BGLAP, ACP5, TNFRSF11B, TNFSF11
35ascorbic acid44 249.6MMP1, TNFRSF11B, SPP1, TNFSF11, CSF1, IBSP
36serine448.4MMP1, TNFRSF11B, TNFSF11, CSF1, BGLAP, CSF1R
37sb 20358044 599.4SPP1, MMP9, MMP1, TNFRSF11B, TNFSF11, BGLAP
38phosphatidylinositol448.4CSF1, SPP1, TNFRSF11B, MMP9, PTHLH, CSF1R
39cyclosporin a44 28 5910.4TNFSF11, CALCR, BGLAP, TNFRSF11B, MMP9, MMP1
40dexamethasone44 49 28 1111.2TNFSF11, MMP9, ACP5, BGLAP, TNFRSF11B, SPP1
41testosterone44 59 11 2411.0MMP9, SPP1, PTHLH, MMP1, PDGFRB, TNFRSF11B
42vitamin d448.0CALCR, SPP1, PTHLH, ACP5, TNFRSF11B, PDGFRB
43tyrosine448.0ACP5, MMP9, TNFRSF11B, TNFSF11, CSF1, SPP1
441,25 dihydroxy vitamin d3448.0TNFRSF11B, PTHLH, ACP5, TNFSF11, CSF1, CSF1R
45calcitriol44 59 11 2410.9BGLAP, CALCR, MMP1, PDGFRB, CSF1, TNFSF11
46retinoic acid44 248.8PDGFRB, SPP1, PTHLH, MMP9, MMP1, BGLAP
47creatinine447.7TNFRSF11B, PTHLH, ACP5, MMP9, MMP1, TNFSF11
48cysteine447.7MMP9, MMP1, IBSP, TNFRSF11B, TNFSF11, BGLAP
49vegf447.6SPP1, MMP9, MMP1, TNFSF11, CSF1, CSF1R
50paraffin447.4PTHLH, CSF1, CSF1R, PDGFRB, IBSP, BGLAP

GO Terms for genes affiliated with Pigmented Villonodular Synovitis

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16Gene Ontology
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Cellular components related to Pigmented Villonodular Synovitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane-bounded vesicleGO:0319889.4SPP1, BGLAP
2extracellular spaceGO:0056157.9PTHLH, PVR, BGLAP, CSF1, TNFSF11, TNFRSF11B
3extracellular regionGO:0055767.8SPP1, BGLAP, IBSP, TNFSF11, TNFRSF11B, MMP1

Biological processes related to Pigmented Villonodular Synovitis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1osteoclast proliferationGO:00215810.1CSF1, TNFSF11
2positive regulation of bone resorptionGO:04578010.0SPP1, TNFSF11
3osteoclast differentiationGO:0303169.9CSF1R, CSF1, TNFSF11
4macrophage differentiationGO:0302259.9MMP9, CSF1R, CSF1
5phosphatidylinositol metabolic processGO:0464889.8CSF1R, PDGFRB
6ossificationGO:0015039.8TNFSF11, CSF1, IBSP
7extracellular matrix organizationGO:0301989.5MMP9, SPP1, TNFRSF11B, IBSP, MMP1
8regulation of bone resorptionGO:0451249.5BGLAP, CSF1R
9response to vitamin DGO:0332809.1BGLAP, SPP1
10skeletal system developmentGO:0015019.1PTHLH, BGLAP, MMP9, TNFRSF11B

Molecular functions related to Pigmented Villonodular Synovitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.5SPP1, TNFRSF11B, TNFSF11, CSF1

Products for genes affiliated with Pigmented Villonodular Synovitis

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Sources for Pigmented Villonodular Synovitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet