MCID: PGM001
MIFTS: 48

Pigmented Villonodular Synovitis malady

Categories: Rare diseases, Bone diseases, Reproductive diseases, Muscle diseases

Aliases & Classifications for Pigmented Villonodular Synovitis

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Sources:
66UMLS, 11Disease Ontology, 46NIH Rare Diseases, 13DISEASES, 52Orphanet, 48Novoseek, 37MeSH, 28ICD10, 43NCIt, 29ICD10 via Orphanet, 38MESH via Orphanet, 67UMLS via Orphanet, 60SNOMED-CT
See all MalaCards sources

Aliases & Descriptions for Pigmented Villonodular Synovitis:

Name: Pigmented Villonodular Synovitis 11 46 13 52 66
Localized Pigmented Villonodular Synovitis 46
Diffuse Giant Cell Tumor of Tenosynovium 11
Diffuse Pigmented Villonodular Synovitis 46
Fibrous Histiocytoma of Tendon Sheath 66
Synovitis, Pigmented Villonodular 37
Synovitis Pigmented Villonodular 48
Tenosynovial Giant Cell Tumors 46
 
Diffuse-Type Giant Cell Tumor 52
Tenosynovial Giant Cell Tumor 52
Testicular Germ Cell Tumor 66
Villous Tenosynovitis 11
Diffuse-Type Gct 52
Tsgct 52
Tgct 52

Characteristics:

Orphanet epidemiological data:

52
pigmented villonodular synovitis:
Inheritance: Not applicable

Classifications:



External Ids:

Disease Ontology11 DOID:2702
ICD1028 M12.2
MeSH37 D013586
NCIt43 C3401
Orphanet52 ORPHA66627
ICD10 via Orphanet29 M12.2
MESH via Orphanet38 D013586
UMLS via Orphanet67 C0039106

Summaries for Pigmented Villonodular Synovitis

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NIH Rare Diseases:46 Pigmented villonodular synovitis (pvns) is a disease in which the tissue lining the joints and tendons in the body (synovium) grows abnormally. it is characterized by a noncancerous mass or tumor. there are two types of pvns: the local or nodular form (where the tumor involves the tendons that support the joint, or in one area of the joint) and the diffuse form (where the entire lining of the joint is involved). symptoms might include: pain, limitation of movement, and locking of the joint. in some cases, the normal joint structure can be destroyed. the knee is most commonly affected by this condition, though it can occur in other joints such as the hip, shoulder, elbow, ankle, wrist, and rarely the jaw. the average age of diagnosis for this condition is 35 years. the cause of pvns is grossly unknown. treatment involves surgery to remove the tumor and damaged portions of the synovium. last updated: 4/4/2016

MalaCards based summary: Pigmented Villonodular Synovitis, also known as localized pigmented villonodular synovitis, is related to malignant giant cell tumor and rheumatoid arthritis, and has symptoms including pain An important gene associated with Pigmented Villonodular Synovitis is CSF1 (Colony Stimulating Factor 1), and among its related pathways are Signaling events mediated by PTP1B and Signaling events mediated by TCPTP. Affiliated tissues include bone, testes and lung, and related mouse phenotypes are hearing/vestibular/ear and craniofacial.

Wikipedia:69 Pigmented villonodular synovitis (PVNS) is a joint disease characterized by inflammation and overgrowth... more...

Related Diseases for Pigmented Villonodular Synovitis

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Diseases related to Pigmented Villonodular Synovitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1malignant giant cell tumor29.9ACP5, CSF1, MMP9, TNFSF11
2rheumatoid arthritis29.5ACP5, CSF1, CSF1R, MMP9, TNFSF11
3malignant giant cell tumor of the tendon sheath25.6ACP5, CALCR, CSF1, CSF1R, MMP9, PTPN11
4villonodular synovitis12.0
5noonan syndrome 111.7
6testicular germ cell tumor11.6
7synovitis11.4
8giant cell tumor10.7
9tenosynovial giant cell tumor10.6
10cyclosporiasis10.5ACP5, MMP9
11arthritis10.5
12fryns macrocephaly10.5ACP5, PTPN11
13mushroom workers' lung10.4ACP5, TP53
14impotence10.4ACP5, TNFSF11
15mucinoses10.4CSF1, CSF1R
16pasli disease10.4MMP9, TP53
17neuropathy, ataxia, and retinitis pigmentosa10.4ACP5, PTPN11
18pneumatosis cystoides intestinalis10.4ACP5, TNFSF11
19chronic monocytic leukemia10.4CSF1, CSF1R
20brain ischemia10.4MMP9, TP53
21lipoid nephrosis10.3MMP9, TNFSF11
22sporadic idiopathic steroid-resistant nephrotic syndrome with minimal changes10.3CSF1, CSF1R
23polyclonal hypergammaglobulinemia10.3CSF1, TNFSF11
24bacillary angiomatosis10.3ACP5, TNFSF11
25scrotal carcinoma10.3ACP5, TNFSF11
26uv-sensitive syndrome 310.3PTPN11, TNFSF11
27conversion disorder10.3MMP9, TP53
28bone resorption disease10.3ACP5, TNFSF11
29adult ependymoblastoma10.3CSF1R, TP53
30sarcoma10.3
31tuberculosis10.3
32neuropathy10.3
33synovial chondromatosis10.3
34chronic rheumatic pericarditis10.3CSF1, TNFSF11
35histidine metabolism disease10.2MMP9, TP53
36nail disorder, nonsyndromic congenital, 110.2CSF1, TNFSF11
37keloids10.2CSF1, TNFSF11
38proximal symphalangism10.2CSF1R, MMP9
39stromal keratitis10.2MMP9, TP53
40mantle cell lymphoma10.2MMP9, TP53
41integumentary system cancer10.2MMP9, TP53
42osteonecrosis10.2
43hemarthrosis10.2
44gallbladder papillary carcinoma10.2MMP9, TP53
45oral lichen planus10.1MMP9, TP53
46diffuse pulmonary fibrosis10.1ACP5, PTPRC
47inflammatory liposarcoma10.1ACP5, MMP9, TNFSF11
48giant cell glioblastoma10.1MMP9, PTPN11, TP53
49van buchem disease, type 210.1CSF1, TNFSF11
50physical disorder10.0ACP5, TNFSF11

Graphical network of the top 20 diseases related to Pigmented Villonodular Synovitis:



Diseases related to pigmented villonodular synovitis

Symptoms for Pigmented Villonodular Synovitis

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UMLS symptoms related to Pigmented Villonodular Synovitis:


pain

Drugs & Therapeutics for Pigmented Villonodular Synovitis

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Drugs for Pigmented Villonodular Synovitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
PaclitaxelPhase 1269133069-62-436314
Synonyms:
(2AR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha r*,betas*),11alpha,12alpha,12balpha))-beta-(benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester
12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
157069-30-2
33069-62-4
5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxete,benzenepropanoic acid deriv.
7-Epi-Paclitaxel
7-Epi-Taxol
7-Epipaclitaxel
7-Epitaxol
7-epi-Paclitaxel
7-epi-Taxol
AB00513812
ABI 007
ABI-007
ABI007
AC-675
AC1L1IOG
AC1L1VJI
AC1L9AVF
ACon1_002231
ANX-513
Abraxane
Abraxane (TN)
Abraxane I.V. Suspension
Abraxis BioScience brand of albumin-bound paclitaxel
Ambotz33069-62-4
Anzatax
Asotax
BIDD:PXR0046
BMS 181339-01
BMS-181339
BMS-181339-01
BPBio1_000320
BRD-A23723433-001-01-2
BRD-A28746609-001-04-0
BRD-K62008436-001-03-1
BSPBio_000290
BSPBio_001152
BSPBio_002614
Bio-0076
Bio1_000362
Bio1_000851
Bio1_001340
Bio2_000416
Bio2_000896
Bristaxol
C07394
C466458
C47H51NO14
CCRIS 8143
CHEBI:103439
CHEBI:45863
CHEMBL100910
CHEMBL418410
CHEMBL48
CID36314
CID441276
CID4666
CID6713921
CID6915727
CPD-8718
Capxol
D00491
DB01229
DHP-107
DHP-208
DRG-0190
DTS-301
DivK1c_000441
EU-0101201
Ebetaxel
EmPAC
Epitaxol
Genaxol
Genetaxyl
Genexol
Genexol-PM
HMS1362J13
HMS1568O12
HMS1792J13
HMS1922K08
HMS1990J13
HMS2090D07
HMS2093K15
HMS501G03
HSDB 6839
I06-0014
IDI1_000441
IDI1_002171
Intaxel
KBio1_000441
KBio2_000492
KBio2_002016
KBio2_002509
KBio2_003060
KBio2_004584
KBio2_005077
KBio2_005628
KBio2_007152
KBio2_007645
KBio3_000903
KBio3_000904
KBio3_001834
KBio3_002987
KBioGR_000492
KBioGR_001893
 
KBioGR_002509
KBioSS_000492
KBioSS_002016
KBioSS_002517
LMPR0104390001
LS-31070
LipoPac
Lopac0_001201
MBT 0206
MEGxp0_001940
MLS000863266
MLS001077297
MLS002154218
MLS002172439
MLS002695976
MPI-5018
Micellar Paclitaxel
Mitotax
MolPort-001-742-627
MolPort-003-665-783
MolPort-003-932-365
NCGC00024995-02
NCGC00024995-03
NCGC00024995-04
NCGC00024995-05
NCGC00024995-06
NCGC00024995-07
NCGC00164367-01
NCGC00164367-02
NCGC00164367-03
NCI60_000601
NINDS_000441
NK 105
NP-010981
NSC 125973
NSC-125973
NSC125973
NSC358882
Nanotaxel
Neuro_000060
Nova-12005
OAS-PAC-100
OncoGel
Onxal
Onxol
Onxol, Taxol, Nov-Onxol, Paclitaxel
P1632
Paclical
Pacligel
Paclitaxel
Paclitaxel (JAN/USP)
Paclitaxel (JAN/USP/INN)
Paclitaxel (Taxol)
Paclitaxel [USAN:INN:BAN]
Paxceed
Paxene
Paxoral
Plaxicel
Praxel
Prestwick0_000155
Prestwick1_000155
Prestwick2_000155
Prestwick3_000155
Probes2_000350
QW 8184
S-8184 Paclitaxel Injectable Emulsion
S1150_Selleck
SDCCGMLS-0066823.P001
SDP-013
SMP1_000228
SMR000394086
SMR000857385
SPBio_000943
SPBio_002229
SPECTRUM1503908
ST50306996
Spectrum2_000872
Spectrum3_001057
Spectrum4_001197
Spectrum5_001491
Spectrum_001536
T 7402
T1912_SIGMA
T7191_SIGMA
T7402_SIGMA
TA1
TAXOL (TN)
TAXOL, 10-EPI,
TXL
TaxAlbin
Taxol
Taxol A
Taxol Konzentrat
Taxol.RTM. (Registered Trademark)
UNII-P88XT4IS4D
UPCMLD-DP108:001
UPCMLD-DP108:002
Vascular Wrap
Xorane
Yewtaxan
abi-007
albumin-bound paclitaxel
cMAP_000068
nab-paclitaxel
nchembio.188-comp1
nchembio.2007.34-comp9
nchembio.215-comp9
nchembio853-comp6
paclitaxel
weekly paclitaxel

Interventional clinical trials:

idNameStatusNCT IDPhase
1PLX3397 Phase 3 Study for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS)Active, not recruitingNCT02371369Phase 3
2Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT)CompletedNCT01261429Phase 2
3MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCTTS)RecruitingNCT01643850Phase 2
4Study of FPA008 in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell TumorRecruitingNCT02471716Phase 1, Phase 2
5Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell TumorActive, not recruitingNCT01207492Phase 2
6A Study of PLX73086 in Advanced Solid Tumors and Locally Advanced or Refractory Tenosynovial Giant Cell TumorRecruitingNCT02673736Phase 1
7Phase 1 Study of PLX7486 as Single Agent in Patients With Advanced Solid TumorsRecruitingNCT01804530Phase 1
8Safety Study of PLX108-01 in Patients With Solid TumorsActive, not recruitingNCT01004861Phase 1
9A Study of RO5509554 as Monotherapy and in Combination With Paclitaxel in Participants With Advanced Solid TumorsActive, not recruitingNCT01494688Phase 1

Search NIH Clinical Center for Pigmented Villonodular Synovitis


Cochrane evidence based reviews: synovitis, pigmented villonodular

Genetic Tests for Pigmented Villonodular Synovitis

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Anatomical Context for Pigmented Villonodular Synovitis

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MalaCards organs/tissues related to Pigmented Villonodular Synovitis:

34
Bone, Testes, Lung

Animal Models for Pigmented Villonodular Synovitis or affiliated genes

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MGI Mouse Phenotypes related to Pigmented Villonodular Synovitis:

39 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.0CSF1, CSF1R, PTPN11, TP53
2MP:00053828.6CSF1, CSF1R, PTPN11, TNFSF11, TP53
3MP:00053698.3CSF1, MMP9, PTPN11, TNFSF11, TP53
4MP:00053918.1CSF1, MMP9, PTPN11, TNFSF11, TP53
5MP:00107718.1CSF1, CSF1R, MMP9, PTPN11, TNFSF11, TP53
6MP:00053897.9CSF1, CSF1R, MMP9, PTPN11, TNFSF11, TP53
7MP:00030127.8CSF1, CSF1R, PTPN11, PTPRC, TNFSF11, TP53
8MP:00053887.7CSF1, MMP9, PTPN11, PTPRC, TNFSF11, TP53
9MP:00053797.6CSF1, CSF1R, PTPN11, PTPRC, TNFSF11, TP53
10MP:00028737.6CALCR, CSF1R, PTPN11, PTPRC, TNFSF11, TP53
11MP:00053717.3CALCR, CSF1, CSF1R, MMP9, PTPN11, TNFSF11
12MP:00053787.1CSF1, CSF1R, MMP9, PTPN11, PTPRC, TNFSF11
13MP:00053877.0CALCR, CSF1, CSF1R, MMP9, PTPN11, PTPRC
14MP:00053976.9CALCR, CSF1, CSF1R, MMP9, PTPN11, PTPRC
15MP:00107686.7CALCR, CSF1, CSF1R, MMP9, PTPN11, PTPRC
16MP:00053766.7CALCR, CSF1, CSF1R, MMP9, PTPN11, PTPRC
17MP:00053906.6CALCR, CSF1, CSF1R, MMP9, PTPN11, PTPRC

Publications for Pigmented Villonodular Synovitis

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Articles related to Pigmented Villonodular Synovitis:

(show top 50)    (show all 564)
idTitleAuthorsYear
1
Pigmented Villonodular Synovitis: A Comprehensive Review and Proposed Treatment Algorithm. (27509331)
2016
2
Pigmented villonodular synovitis mimics metastases on fluorine 18 fluorodeoxyglucose position emission tomography-computed tomography. (27190776)
2016
3
Acute Knee Pain in a Child Due to Pigmented Villonodular Synovitis. (27299078)
2015
4
Computed Tomography and Magnetic Resonance Manifestations of Spinal Pigmented Villonodular Synovitis. (25836023)
2015
5
Tenosynovial giant cell tumour (pigmented villonodular synovitis-)-like changes in periprosthetic interface membranes. (26553457)
2015
6
Metastasizing tenosynovial giant cell tumour, diffuse type/pigmented villonodular synovitis. (26052431)
2015
7
Postoperative radiotherapy for diffuse pigmented villonodular synovitis of the temporomandibular joint. (25459320)
2015
8
Intra-articular post-traumatic ankle joint mass imitating localized pigmented villonodular synovitis (LPVS), the aid of ankle arthroscopy for diagnosis and treatment-A case report. (25637030)
2015
9
Arthroscopic Synovectomy and Postoperative Assisted Radiotherapy for Treating Diffuse Pigmented Villonodular Synovitis of the Knee: An observational retrospective study. (26430437)
2015
10
Pigmented villonodular synovitis diagnostic delay due to coexistence with ankylosing spondylitis. (24642231)
2014
11
Low-dose external beam radiotherapy as a postoperative treatment for patients with diffuse pigmented villonodular synovitis of the knee: 4 recurrences in 23 patients followed for mean 9 years. (22489888)
2012
12
Hip joint pigmented villonodular synovitis in a young girl: a case report. (22433958)
2012
13
Pigmented villonodular synovitis of the ankle presenting as a persisting ankle effusion. (22764668)
2012
14
The management of diffuse-type giant cell tumour (pigmented villonodular synovitis) and giant cell tumour of tendon sheath (nodular tenosynovitis). (22733940)
2012
15
Pigmented villonodular synovitis of the temporomandibular joint: a radiologic diagnosis and case report. (21783297)
2012
16
Tuberculous arthritis of the knee joint mimicking pigmented villonodular synovitis. (21912886)
2012
17
Radiation therapy for treatment of pigmented villonodular synovitis: results of a national patterns of care study. (20488628)
2010
18
Arthroscopic treatment of pigmented villonodular synovitis involving bilateral shoulders. (20806759)
2010
19
Tenosynovial giant cell tumor and pigmented villonodular synovitis: a proposal for unification of these clinically distinct but histologically and genetically identical lesions. (17225151)
2007
20
Pigmented villonodular synovitis of the pes anserine bursa. (17665791)
2007
21
Pigmented villonodular synovitis associated with pathological fracture of the odontoid and atlantoaxial instability. Case report and review of the literature. (17688068)
2007
22
Diffuse-type giant cell tumor/pigmented villonodular synovitis arising in the sacrum: malignant form. (17685937)
2007
23
Clustered localized pigmented villonodular synovitis. (15944639)
2005
24
Localized pigmented villonodular synovitis in the anteromedial compartment of the knee associated with cartilage lesions of the medial femoral condyle: report of a case and review of the literature. (14749916)
2005
25
Strong expression of Bcl-2 in pigmented villonodular synovitis of the knee with aggressive clinical behaviour. (15903030)
2005
26
Pigmented villonodular synovitis: an uncommon presentation of anterior hip pain. (15668561)
2005
27
Pigmented villonodular synovitis: a disease in evolution. (15290750)
2004
28
Localized pigmented villonodular synovitis in an unusual location in the knee. (12579146)
2003
29
Tuberculosis of the hip as the presenting sign of HIV and simulating pigmented villonodular synovitis. (12107577)
2002
30
Arthroscopic treatment of pigmented villonodular synovitis of the shoulder. (11154374)
2001
31
Giant cell tumor of tendon sheath, tenosynovial giant cell tumor, and pigmented villonodular synovitis: defining the presentation, surgical therapy and recurrence. (10671695)
2000
32
Magnetic resonance imaging evaluation and arthroscopic resection of localized pigmented villonodular synovitis of the knee. (10791586)
2000
33
Localized pigmented villonodular synovitis involving the fat pad of the knee. (11281333)
2000
34
Lipoma induced by pigmented villonodular synovitis of the ankle. (10359296)
1999
35
An unusual case of pigmented villonodular synovitis of the spine: benign aggressive and/or malignant? (10371292)
1999
36
Pigmented villonodular synovitis of the elbow. (9524343)
1998
37
Diagnostic features of diffuse pigmented villonodular synovitis of the knee. (8118978)
1994
38
Localized pigmented villonodular synovitis of the patellar fat pad: a report of two cases. (7945635)
1994
39
Pigmented villonodular synovitis of the sequestered suprapatellar bursa. (8070197)
1994
40
Pigmented villonodular synovitis of the knee demonstrated on bone scan. Correlation with US, CT, and MRI. (1424384)
1992
41
Pigmented villonodular synovitis and synovial cysts of the spine [ comment]. (1595437)
1992
42
Case report 578: Pigmented villonodular synovitis of the shoulder. (2321043)
1990
43
Pigmented villonodular synovitis in a vertebra. A case report. (2365726)
1990
44
Diffuse pigmented villonodular synovitis of the temporomandibular joint diagnosed by fine-needle aspiration cytology. (2791838)
1989
45
Case report 563: Pigmented villonodular synovitis (PVNS) of knee. (2814557)
1989
46
Pigmented villonodular synovitis of the knee: results from 13 cases. (2706054)
1989
47
Radiologic case study. Diffuse pigmented villonodular synovitis. (2771816)
1989
48
Pigmented villonodular synovitis of the hip--association with osteochondromatosis. (3440329)
1987
49
Magnetic resonance imaging of pigmented villonodular synovitis: a report of two cases. (3616670)
1987
50
Pigmented villonodular synovitis of the temporomandibular joint: a case report. (10994414)
1982

Variations for Pigmented Villonodular Synovitis

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Expression for genes affiliated with Pigmented Villonodular Synovitis

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Search GEO for disease gene expression data for Pigmented Villonodular Synovitis.

Pathways for genes affiliated with Pigmented Villonodular Synovitis

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GO Terms for genes affiliated with Pigmented Villonodular Synovitis

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Cellular components related to Pigmented Villonodular Synovitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1CSF1-CSF1R complexGO:19906829.8CSF1, CSF1R

Biological processes related to Pigmented Villonodular Synovitis according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1macrophage colony-stimulating factor signaling pathwayGO:003814510.1CSF1, CSF1R
2osteoclast proliferationGO:000215810.1CSF1, TNFSF11
3homeostasis of number of cells within a tissueGO:004887310.0CSF1, PTPN11
4bone resorptionGO:00454539.9ACP5, TNFSF11
5positive regulation of osteoclast differentiationGO:00456729.7CSF1, CSF1R, TNFSF11
6macrophage differentiationGO:00302259.6CSF1, CSF1R, MMP9
7positive regulation of cell migrationGO:00303359.4ACP5, CSF1, CSF1R
8response to gamma radiationGO:00103329.2PTPRC, TP53
9positive regulation of release of cytochrome c from mitochondriaGO:00902008.8MMP9, TP53
10osteoclast differentiationGO:00303168.8ACP5, CALCR, CSF1, CSF1R, TNFSF11
11ossificationGO:00015038.7ACP5, CSF1, MMP9, TNFSF11

Molecular functions related to Pigmented Villonodular Synovitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor tyrosine kinase bindingGO:00309719.1PTPN11, TP53

Sources for Pigmented Villonodular Synovitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet