Pilocytic Astrocytoma malady

NIH Rare Diseases: Pilocytic astrocytoma is a benign brain tumor that grows slowly in the brain or spinal cord."Pilocytic" means that the tumro is made up of cells that look like fibers when viewed under a microscope. "Astrocytoma" describes the type of tumor that begins in the brain or spinal cord in small, star-shaped cells called astrocytes. The tumor may be in the form of a cyst and rarely spreads into nearby tissues. Symptoms vary depending upon the size and location of the tumor. Most symptoms result from increased pressure on the brain and include headaches, nausea, vomiting, balance problems, and vision abnormalities. This type of tumor is most common in children and young adults and in people with neurofibromatosis type 1 (NF1), Li-Fraumeni syndrome, and tuberous sclerosis. A pilocytic astrocytoma rarely causes death. The exact cause of this tumor is unknown.³⁰

MalaCards: Pilocytic Astrocytoma is related to juvenile pilocytic astrocytoma and neurofibromatosis. An important gene associated with Pilocytic Astrocytoma is TNC (tenascin C), and among its related pathways are Sorafenib Pharmacodynamics and Selected targets of p53. The compounds threonine and egcg have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and spinal cord, and related mouse phenotypes are respiratory system and craniofacial.

Wikipedia: Pilocytic astrocytoma or juvenile pilocytic astrocytoma or cystic cerebellar astrocytoma (and its...⁴⁴ more...

pilocytic astrocytoma 30 8 32 43

Diseases related to pilocytic astrocytoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 512)

id	Related Disease	Score	Top Affiliating Genes
1	juvenile pilocytic astrocytoma	34.5	ZBTB20, MBP, TP53, TNC
2	neurofibromatosis	31.5	S100B, HRAS, NF1, PDGFRA, KRAS, TSC1
3	diffuse astrocytoma	31.1	BRAF, LGALS3, CDKN2A, CDK4, MKI67, MGMT
4	ganglioglioma	30.9	S100B, APOD, TP53, GFAP, TSC1, SYP
5	pleomorphic xanthoastrocytoma	29.6	BRAF, CDKN2A, CDK4, TP53, EGFR, GFAP
6	oligodendroglioma	29.5	BRAF, CDKN2A, MGMT, TP73, PTEN, OLIG1
7	glioblastoma	29.0	VEGFA, KDR, LGALS1, CDKN1A, CDKN2A, CDKN3
8	anaplastic oligodendroglioma	28.6	KDR, LGALS3, CDKN2A, CDK4, MGMT, TP53
9	anaplastic astrocytoma	27.5	VEGFA, RAB3IP, LGALS1, LGALS2, LGALS3, LGALS8
10	medulloblastoma	25.6	KDR, S100A4, S100A6, S100B, CDKN1A, CDKN2A
11	astrocytoma	23.6	KIAA1549, BRAF, VEGFA, RAB19, KDR, LGALS1
12	leukemia	20.0	BRAF, VEGFA, KDR, LGALS1, LGALS3, S100A4
13	papillary ependymoma	13.9	S100B, GFAP, SYP
14	anaplastic ganglioglioma	13.9	S100B, GFAP, NES
15	central neurocytoma	13.9	OLIG2, GFAP, SYP
16	ewing's family of tumors	13.9	CDK4, TNC, GFAP, SYP
17	chordoid glioma	13.9	S100B, CDK4, GFAP, SYP
18	anaplastic ependymoma	13.8	S100B, MGMT, PTEN, GFAP
19	pineocytoma	13.8	S100B, MBP, GFAP, SYP
20	subependymal giant cell astrocytoma	13.8	S100B, TSC1, SYP
21	choroid plexus papilloma	13.8	S100B, GFAP, SYP
22	cerebellar liponeurocytoma	13.8	TP53, GFAP, SYP
23	pituitary carcinoma	13.8	LGALS3, MGMT, TP53, GFAP
24	cellular schwannoma	13.8	S100A1, S100B, NF1, GFAP
25	desmoplastic small round cell tumor	13.8	S100B, PDGFA, PDGFRB, SYP
26	pilomyxoid astrocytoma	13.8	KIAA1549, DOCK6, GFAP, SYP
27	head injury	13.7	S100B, MBP, TP53, GFAP, SYP
28	colonic aganglionosis	13.7	S100A1, SYP, SOX10
29	amelanotic melanoma	13.7	LAMP1, S100B, THBS1
30	leukodystrophy	13.7	MBP, OLIG1, OLIG2, GFAP, SOX10
31	plexiform neurofibroma	13.7	TP73, NF1, PDGFRA
32	myoepithelioma	13.7	S100A1, S100B, TP53, GFAP, THBS1
33	ossifying fibromyxoid tumor	13.7	S100A1, S100B, MBP
34	brain malformations	13.7	MBP, CTSD, SYP, DCX
35	pineoblastoma	13.7	TP53, GFAP, SYP
36	oxyphilic adenoma	13.7	LGALS3, S100A1, TSC1, SYP
37	blue rubber bleb nevus syndrome	13.7	S100B, NRAS, NF1
38	central nervous system lymphoma, primary	13.6	MGMT, DAPK1, TIMP3
39	oligoastrocytoma	13.6	MGMT, IDH1, TP53, PDGFRA, GFAP, NES
40	kidney clear cell sarcoma	13.6	BRAF, S100B, ERBB3
41	ganglioneuroma	13.6	S100B, MBP, PTEN, NF1, GFAP, TSC1
42	hereditary cerebral hemorrhage with amyloidosis	13.6	CTSD, GFAP, SYP
43	embryonal sarcoma	13.6	S100B, CDK4, MKI67, TP53
44	thyroid cancer	13.6	BRAF, LGALS1, LGALS3, S100A4
45	chondroma	13.6	S100A1, CDK4, IDH1, PDGFRA
46	spitz nevus	13.6	BRAF, HRAS, TP53, NRAS
47	spindle cell sarcoma	13.6	S100B, MKI67, TP53, NF1
48	familial melanoma	13.6	BRAF, CDKN2A, CDK4, MGMT
49	mesenchymal cell neoplasm	13.6	HRAS, GFAP, SYP
50	hydrocephalus	13.6	MBP, ALDH1L1, TP53, PTEN, NF1, GFAP

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to pilocytic astrocytoma:

²²

MGI Mouse Phenotypes related to pilocytic astrocytoma:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.7	OLIG2, NF1
2	craniofacial phenotype	MP:0005382	9.6	PDGFRB, PDGFRA, NF1, GJA1, TP73, LAMP1
3	endocrine/exocrine gland phenotype	MP:0005379	9.2	KRAS, RANBP9, ONECUT2, ALDH1A1, SOX10, GJA1
4	other phenotype	MP:0005395	8.7	KDR, CDKN2A, GJA1, TP73, NF1, PDGFRA
5	hematopoietic system phenotype	MP:0005397	8.4	CDK4, LGALS3, CDKN1A, GJA1, ERBB4, TP73
6	liver/biliary system phenotype	MP:0005370	8.4	VEGFA, ADM, EGFR, NF1, ONECUT2, TP53
7	pigmentation phenotype	MP:0001186	8.3	SOX10, BRAF, CDKN2A, ERBB3, TP53, PTEN
8	limbs/digits/tail phenotype	MP:0005371	8.3	NF1, KRAS, NRAS, VEGFA, THBS1, EGFR
9	embryogenesis phenotype	MP:0005380	8.0	TP73, SOX10, HIPK2, EGFR, KRAS, NF1
10	no phenotypic analysis	MP:0003012	7.9	SYP, EGFR, DCX, TNR, TP53, GJA1
11	reproductive system phenotype	MP:0005389	7.5	TIMP1, VEGFA, THBS1, KRAS, TSC1, TIMP3
12	renal/urinary system phenotype	MP:0005367	7.4	ADM, LGALS3, THBS1, TIMP3, TSC1, KRAS
13	integument phenotype	MP:0010771	7.3	BRAF, KRAS, EGFR, SOX10, PDGFRA, NF1
14	skeleton phenotype	MP:0005390	7.1	EGFR, LAMP1, LGALS3, KDR, VEGFA, BRAF
15	digestive/alimentary phenotype	MP:0005381	7.0	ERBB3, CDK4, CDKN2A, CDKN1A, VEGFA, LGALS3
16	behavior/neurological phenotype	MP:0005386	6.9	ERBB3, ERBB4, TP73, TNC, PTEN, OLIG2
17	tumorigenesis	MP:0002006	6.8	TSC1, TIMP1, THBS1, EGFR, KRAS, PDGFRA
18	growth/size phenotype	MP:0005378	6.8	NRAS, NF1, PTEN, ZBTB20, RANBP9, OLIG2
19	immune system phenotype	MP:0005387	6.6	LGALS3, ADM, KDR, BRAF, NF1, LAMP2
20	vision/eye phenotype	MP:0005391	6.6	THBS1, PTEN, TP73, TP53, GJA1, ALDH1A1
21	normal phenotype	MP:0002873	6.5	RAB3IP, ALDH1A1, KDR, LGALS1, LAMP1, S100A4
22	nervous system phenotype	MP:0003631	6.3	PDGFA, NF1, CTSD, OLIG2, OLIG1, DAPK1
23	muscle phenotype	MP:0005369	5.6	CDKN2A, CDK4, FLT1, GJA1, ERBB3, TP53
24	cardiovascular system phenotype	MP:0005385	5.1	EGFR, S100A1, TP73, KDR, LGALS3, LAMP2
25	mortality/aging	MP:0010768	4.6	MGMT, VEGFA, FLT1, CDK4, CDKN1A, S100A4
26	cellular phenotype	MP:0005384	4.5	PTEN, TP73, TP53, ERBB4, ERBB3, DAPK1
27	homeostasis/metabolism phenotype	MP:0005376	4.4	PDGFRB, NF1, PDGFA, PDGFRA, LGALS3, KRAS

Articles related to pilocytic astrocytoma:

(show all 45)

id	Title	Authors	Year	Affiliating Genes
1	Analysis of BRAF V600E mutation in 1,320 nervous syst em tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, g anglioglioma and extra-cerebellar pilocytic astrocytoma. (21274720)	Schindler G.... von Deimling A.	2011	BRAF
2	BRAF activation induces transformation and then senes cence in human neural stem cells: a pilocytic astrocytoma model. (21636552)	Raabe E.H.... Eberhart C.G.	2011	BRAF, CDKN2A
3	Adrenomedullin expression and regulation in human gli oblastoma, cultured human glioblastoma cell lines and pilocytic astrocytoma. (21458987)	Metellus P.... Ouafik L.	2011	ADM
4	Vascular endothelial growth factor receptor 2 (VEGFR- 2) signalling activity in paediatric pilocytic astrocytoma is restricted to tum our endothelial cells. (21208252)	Sikkema A.H.... den Dunnen W.F.	2011	KDR
5	Pilocytic astrocytomas have telomere-associated promy elocytic leukemia bodies without alternatively lengthened telomeres. (21037079)	Slatter T.... Hung N.	2010	PML
6	Association of molecular alterations, including BRAF, with biology and outcome in pilocytic astrocytomas. (20044755)	Horbinski C.... Pollack I.F.	2010	BRAF
7	Distribution of lysosome-associated membrane proteins -1 and -2, and cathepsin D in eosinophilic granular bodies: possible relationsh ip to cyst development in pilocytic astrocytomas. (20926008)	Tung J.N.... Jiang M.C.	2010	CTSD, LAMP2, LAMP1
8	KIAA0510, the 3'-untranslated region of the tenascin- R gene, and tenascin-R are overexpressed in pilocytic astrocytomas. (20202125)	El Ayachi I.... Figarella-Branger D.	2010	TNR
9	Impact of morphology, MIB-1, p53 and MGMT on outcome in pilocytic astrocytomas. (19832838)	Horbinski C.... Pollack I.F.	2010	TP53, MGMT, MKI67
10	Combined molecular analysis of BRAF and IDH1 distingu ishes pilocytic astrocytoma from diffuse astrocytoma. (19543740)	Korshunov A.... Hartmann C.	2009	BRAF, IDH1
11	Alterations of BRAF and HIPK2 loci predominate in spo radic pilocytic astrocytoma. (19794125)	Yu J.... Gutmann D.H.	2009	BRAF, HIPK2
12	Real-time quantitative polymerase chain reaction (qPC R) analysis with fluorescence resonance energy transfer (FRET) probes reveals d ifferential expression of the four ERBB4 juxtamembrane region variants between medulloblastoma and pilocytic astrocytoma. (19017278)	Zeng N.... Collins V.P.	2009	ERBB4
13	Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas. (19373855)	Forshew T.... Sheer D.	2009	BRAF
14	Expression of oligodendroglial differentiation markers in pilocytic astrocytomas identifies two clinical subsets and shows a significant correlation with proliferation index and progression free survival. (17690840)	Takei H.... Adesina A.M.	2008	PDGFRA, MBP, OLIG2
15	Gene expression profiling of NF-1-associated and sporadic pilocytic astrocytoma identifies aldehyde dehydrogenase 1 family member L1 (ALDH1L1) as an underexpressed candidate biomarker in aggressive subtypes. (19018242)	Rodriguez F.J.... Gutmann D.H.	2008	ALDH1A1, ALDH1L1
16	Clinicopathologic study of pilocytic astrocytoma]. (19094585)	Zhao Y.C.... Zhang R.S.	2008	GFAP
17	Frequent gains at chromosome 7q34 involving BRAF in pilocytic astrocytoma. (18716556)	Bar E.E.... Eberhart C.G.	2008	BRAF, HIPK2
18	High-resolution, dual-platform aCGH analysis reveals frequent HIPK2 amplification and increased expression in pilocytic astrocytomas. (18408760)	Deshmukh H.... Nagarajan R.	2008	HIPK2
19	Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas. (18974108)	Jones D.T.... Collins V.P.	2008	BRAF, KIAA1549
20	Diversity of glial cell components in pilocytic astrocytoma. (18312545)	Tanaka Y.... Nakazato Y.	2008	GFAP, MKI67, OLIG2
21	Further evidence for a somatic KRAS mutation in a pilocytic astrocytoma. (17712732)	Janzarik W.G.... Omran H.	2007	HRAS, NRAS, NF1
22	Matrilin-2 expression distinguishes clinically relevant subsets of pilocytic astrocytoma. (16401863)	Sharma M.K.... Gutmann D.H.	2006	MATN2
23	Paired overexpression of ErbB3 and Sox10 in pilocytic astrocytoma. (16896310)	Addo-Yobo S.O.... Foreman N.K.	2006	ERBB3, SOX10
24	Identification of genes differentially expressed in glioblastoma versus pilocytic astrocytoma using Suppression Subtractive Hybridization. (16314830)	Colin C.... Figarella-Branger D.	2006	HTRA1
25	Pilocytic astrocytoma presenting as primary diffuse leptomeningeal gliomatosis: report of a unique case and review of the literature. (16003541)	Bohner G.... van Landeghem F.K.	2005	PTEN, CDKN3
26	Expression analysis of juvenile pilocytic astrocytoma s by oligonucleotide microarray reveals two potential subgroups. (15665281)	Wong K.K.... Lau C.C.	2005	MBP
27	RAS pathway activation and an oncogenic RAS mutation in sporadic pilocytic astrocytoma. (16247081)	Sharma M.K.... Gutmann D.H.	2005	KRAS
28	Altered expression of immune defense genes in pilocytic astrocytomas. (16215461)	Huang H.... Ohgaki H.	2005	PDGFRA, EGFR, CDKN1A
29	Galectin-3 as an immunohistochemical tool to distinguish pilocytic astrocytomas from diffuse astrocytomas, and glioblastomas from anaplastic oligodendrogliomas. (15605987)	Neder L.... Zago M.A.	2004	LGALS3
30	Marked regression of metastatic pilocytic astrocytoma during treatment with imatinib mesylate (STI-571, Gleevec): a case report and laboratory investigation. (12902920)	McLaughlin M.E.... Cameron S.	2003	PDGFRB
31	Epigenetic changes in pilocytic astrocytomas and medulloblastomas. (12684707)	Gonzalez-Gomez P.... Rey J.A.	2003	TP53, DAPK1, MGMT
32	Preliminary observations on genetic alterations in pilocytic astrocytomas associated with neurofibromatosis 1. (14565158)	TADA K.... Ushio Y.	2003	PTEN, NF1
33	Comparative gene expression profile analysis of neurofibromatosis 1-associated and sporadic pilocytic astrocytomas. (11929829)	Gutmann D.H.... Watson M.A.	2002	GJA1, APOD
34	Mutational and expression analysis of the NF1 gene argues against a role as tumor suppressor in sporadic pilocytic astrocytomas. (12387455)	Wimmer K.... Pietsch T.	2002	NF1
35	Galectins are differentially expressed in supratentorial pilocytic astrocytomas, astrocytomas, anaplastic astrocytomas and glioblastomas, and significantly modulate tumor astrocyte migration. (11145198)	Camby I.... Kiss R.	2001	LGALS3, LGALS1, LGALS8
36	Cancer-related gene expression profiles in NF1-associated pilocytic astrocytomas. (11294925)	Li J.... Gutmann D.H.	2001	CDK4, EGFR, NF1
37	Loss of NF1 alleles distinguish sporadic from NF1-associated pilocytic astrocytomas. (11556548)	Kluwe L.... Mautner V.F.	2001	NF1
38	Pilocytic astrocytomas do not show most of the genetic changes commonly seen in diffuse astrocytomas. (11119125)	Cheng Y.... Poon W.S.	2000	CDK4, TP53, PTEN
39	Clinicopathological analysis of pilocytic astrocytomas and gangliogliomas in children. (10581849)	Fiks T.... Liberski P.P.	1999	GFAP
40	High frequency of TP53 mutations in juvenile pilocytic astrocytomas indicates role of TP53 in the development of these tumors. (10416986)	Hayes V.M.... Buys C.H.	1999	TP53
41	Supratentorial pilocytic astrocytomas, astrocytomas, anaplastic astrocytomas and glioblastomas are characterized by a differential expression of S100 proteins. (9989446)	Camby I.... Decaestecker C.	1999	S100B, S100A4, S100A2
42	MIB-1 and p53 immunocytochemistry for differentiating pilocytic astrocytomas and astrocytomas from anaplastic astrocytomas and glioblastomas in children and young adults. (9839169)	Matsumoto T.... Sato K.	1998	TP53
43	Expression of vascular endothelial growth factor and its receptors in pilocytic astrocytoma. (9255258)	Leung S.Y.... Chung L.P.	1997	FLT1, VEGFA
44	p53 gene mutations in human astrocytic brain tumors including pilocytic astrocytomas. (8666369)	Patt S.... BrockmAPller J.	1996	TP53
45	Deletion of chromosome arm 17p DNA sequences in pediatric high-grade and juvenile pilocytic astrocytomas. (7536455)	Willert J.R.... Cogen P.H.	1995	TP53

Genes related to pilocytic astrocytoma according to GeneCards:

(show top 50)    (show all 75)

id	Symbol	Description	Score	GeneCards Section Context
1	TNC	tenascin C	11.0
2	OLIG2	oligodendrocyte lineage transcription factor 2	11.0	Publications
3	SOX10	SRY (sex determining region Y)-box 10	11.0	Publications
4	IDH1	isocitrate dehydrogenase 1 (NADP+), soluble	11.0	Publications
5	APOD	apolipoprotein D	11.0	Publications
6	PDGFA	platelet-derived growth factor alpha polypeptide	11.0	Publications
7	TIMP3	TIMP metallopeptidase inhibitor 3	11.0	Publications
8	LGALS3	lectin, galactoside-binding, soluble, 3	11.0	Publications
9	DCX	doublecortin	11.0
10	NES	nestin	11.0
11	BRAF	v-raf murine sarcoma viral oncogene homolog B1	11.0	Publications
12	THBS1	thrombospondin 1	11.0	Publications
13	GFAP	glial fibrillary acidic protein	11.0	Publications
14	NF1	neurofibromin 1	11.0	Publications
15	TSC1	tuberous sclerosis 1	11.0
16	CDK4	cyclin-dependent kinase 4	11.0	Publications
17	SYP	synaptophysin	11.0
18	MBP	myelin basic protein	11.0	Publications
19	PTEN	phosphatase and tensin homolog	11.0	Publications
20	PDGFRB	platelet-derived growth factor receptor, beta polypeptide	11.0	Publications
21	MGMT	O-6-methylguanine-DNA methyltransferase	11.0	Publications
22	S100B	S100 calcium binding protein B	11.0	Publications
23	FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	11.0	Publications
24	TP73	tumor protein p73	11.0	Publications
25	TP53	tumor protein p53	11.0	Publications
26	OLIG1	oligodendrocyte transcription factor 1	11.0	Publications
27	S100A5	S100 calcium binding protein A5	11.0	Publications
28	HIPK2	homeodomain interacting protein kinase 2	11.0	Publications
29	LGALS2	lectin, galactoside-binding, soluble, 2	11.0	Publications
30	FAM131B	family with sequence similarity 131, member B	11.0
31	SRGAP2	SLIT-ROBO Rho GTPase activating protein 2	11.0
32	S100A3	S100 calcium binding protein A3	11.0	Publications
33	CALY	calcyon neuron-specific vesicular protein	11.0
34	RAB19	RAB19, member RAS oncogene family	11.0
35	TUBG2	tubulin, gamma 2	11.0
36	S100A2	S100 calcium binding protein A2	11.0	Publications
37	LGALS8	lectin, galactoside-binding, soluble, 8	11.0	Publications
38	S100A6	S100 calcium binding protein A6	11.0	Publications
39	LAMP2	lysosomal-associated membrane protein 2	11.0	Publications
40	LAMP1	lysosomal-associated membrane protein 1	11.0	Publications
41	ONECUT2	one cut homeobox 2	11.0
42	KIAA1549	KIAA1549	11.0	Publications
43	DOCK6	dedicator of cytokinesis 6	11.0	Disorders
44	S100A4	S100 calcium binding protein A4	11.0	Publications
45	S100A1	S100 calcium binding protein A1	11.0	Publications
46	RAB3IP	RAB3A interacting protein (rabin3)	11.0	Disorders
47	HTRA1	HtrA serine peptidase 1	11.0	Publications
48	ALDH1L1	aldehyde dehydrogenase 1 family, member L1	11.0	Publications
49	ALDH1A1	aldehyde dehydrogenase 1 family, member A1	11.0	Publications
50	NRAS	neuroblastoma RAS viral (v-ras) oncogene homolog	11.0	Publications

Pathways related to pilocytic astrocytoma according to GeneDecks:

(show top 50)    (show all 112)

id	Pathway	Score	Top Affiliating Genes
1	Sorafenib Pharmacodynamics34	9.8	HRAS, PDGFRB, KRAS, FLT1, KDR, BRAF
2	Selected targets of p5310	9.8	DAPK1, TP53, MGMT, CDK4, CDKN1A, S100A2
3	Transcription P53 signaling pathway10	9.7	CDKN2A, TP53, VEGFA
4	JNK Pathway36	9.7	KDR, FLT1, HRAS, TP53, NRAS, PDGFRA
5	Pathway_PA16595942534	9.7	BRAF, HRAS, KRAS, PDGFRB, FLT1, NRAS
6	Non-small cell lung cancer20	9.7	HRAS, KRAS, BRAF, CDKN2A, CDK4, NRAS
7	Akt Signaling36	9.5	PDGFRA, PDGFRB, TIMP3, TSC1, PDGFA, NRAS
8	Pathway_PA16598005034	9.5	BRAF, KDR, KRAS, HRAS, FLT1, NRAS
9	p53 signaling pathway20	9.5	TP53, CDKN2A, CDK4, THBS1, PTEN, TP73
10	PPAR Pathway36	9.3	FLT1, NRAS, PDGFRA, PDGFRB, EGFR
11	Chronic myeloid leukemia20	9.3	CDKN2A, BRAF, CDKN1A, CDK4, HRAS, TP53
12	Breast Cancer Regulation by Stathmin136	9.2	TIMP3, ERBB3, ERBB4, PDGFA, EGFR
13	Endometrial cancer20	9.1	EGFR, KRAS, NRAS, PTEN, HRAS, BRAF
14	Rac1 Pathway36	9.1	TIMP1, PDGFRB, PDGFA, NRAS, HRAS, KDR
15	VEGF Signaling Pathway34	9.1	VEGFA, KDR, FLT1, HRAS, KRAS, NRAS
16	Gap junction20	8.7	HRAS, KRAS, PDGFRB, PDGFRA, PDGFA, EGFR
17	ERK5 Signaling36	8.7	EGFR, TIMP3, PDGFRB, PDGFA, NRAS, HRAS
18	PTEN Pathway36	8.7	TNC, TP53, PDGFRB, TIMP3, PDGFA, NRAS
19	eIF2 Pathway36	8.7	NRAS, TIMP3, TIMP1, EGFR, PDGFRB, PDGFRA
20	Glioblastoma Multiforme36	8.7	TSC1, EGFR, PDGFRB, PDGFRA, PDGFA, NRAS
21	Prostate cancer20	8.6	EGFR, KRAS, PDGFRB, PDGFRA, PDGFA, NRAS
22	p53 Mediated Apoptosis36	8.6	TP53, KDR, TIMP3, TIMP1, EGFR, PDGFRB
23	14-3-3 Induced Intracellular Signaling36	8.6	ERBB3, HRAS, ERBB4, NRAS, PDGFRB, TSC1
24	Activation of PKA through GPCR36	8.5	PDGFA, NRAS, ERBB3, TIMP1, PDGFRA, KDR
25	Apoptotic Pathways in Synovial Fibroblasts36	8.5	KDR, FLT1, TP53, PDGFA, PDGFRA, PDGFRB
26	Activation of cAMP-Dependent PKA36	8.3	PDGFRB, TIMP3, TIMP1, PDGFRA, PDGFA, ERBB4
27	Mitochondrial Apoptosis36	8.2	KDR, CDKN2A, FLT1, TP53, PDGFRA, PDGFRB
28	Glioma20	8.2	BRAF, CDKN1A, CDKN2A, CDK4, HRAS, TP53
29	Melanoma20	8.2	CDK4, HRAS, TP53, PTEN, NRAS, PDGFA
30	Focal adhesion20	8.1	PDGFA, FLT1, BRAF, HRAS, TNR, KDR
31	ErbB signaling pathway20	8.1	CDKN1A, EGFR, HRAS, KRAS, ERBB3, NRAS
32	P2Y Receptor Signaling36	8.1	HRAS, ERBB3, ERBB4, NRAS, PDGFRB, PDGFRA
33	Cellular Apoptosis Pathway36	8.0	PDGFRA, TP53, CDKN2A, KDR, PDGFA, EGFR
34	Telomerase Components in Cell Signaling36	8.0	PDGFRB, PDGFA, TP53, FLT1, KDR, PDGFRA
35	Pathways in cancer20	8.0	EGFR, CDK4, TP53, KRAS, PTEN, DAPK1
36	Rap1 Pathway36	7.8	EGFR, ERBB4, ERBB3, HRAS, BRAF, TIMP3
37	ERK Signaling36	7.8	PDGFRA, BRAF, PDGFRB, EGFR, TIMP1, ERBB4
38	Ras Pathway36	7.8	EGFR, PDGFA, ERBB4, NRAS, TIMP3, ERBB3
39	Paxillin Interactions36	7.8	NRAS, ERBB3, PDGFA, PDGFRB, EGFR, TIMP1
40	Bladder cancer20	7.7	EGFR, BRAF, VEGFA, CDKN1A, CDK4, HRAS
41	Nanog in Mammalian ESC Pluripotency36	7.5	TIMP3, KDR, PDGFRB, PDGFRA, BRAF, TIMP1
42	Estrogen Pathway36	7.5	PDGFA, NRAS, ERBB4, FLT1, PDGFRA, PDGFRB
43	GPCR Pathway36	7.5	ERBB3, ERBB4, PDGFA, TIMP1, EGFR, PDGFRB
44	GSK3 Signaling36	7.5	HRAS, PDGFA, PDGFRA, ERBB4, ERBB3, FLT1
45	MAPK Signaling36	7.4	PDGFRA, PDGFRB, EGFR, TIMP1, TIMP3, TP53
46	JAK-STAT Pathway36	7.3	TIMP3, TIMP1, EGFR, PDGFRB, PDGFRA, ERBB3
47	p38 Signaling36	7.2	TIMP3, TIMP1, HRAS, FLT1, ERBB3, ERBB4
48	Intracellular Calcium Signaling36	7.2	TIMP1, NRAS, PDGFRB, PDGFRA, EGFR, TIMP3
49	Pancreatic Adenocarcinoma36	7.1	EGFR, TIMP1, TIMP3, PDGFRA, PDGFRB, KDR
50	Molecular Mechanisms of Cancer36	6.6	KDR, CDKN1A, CDKN2A, CDK4, SOX10, TIMP3

Compounds related to pilocytic astrocytoma according to GeneDecks:

(show top 50)    (show all 173)

id	Compound	Score	Top Affiliating Genes
1	threonine32	10.5	HIPK2, DAPK1
2	egcg32	10.0	PDGFRB, TIMP1, ERBB3
3	o6-methylguanine32	9.6	BRAF, CDKN2A, MGMT, TP53, TP73, KRAS
4	h2o232	9.6	LGALS3, CDKN3, MBP, HTRA1, GJA1, PDGFRB
5	hematoxylin32	9.4	MKI67, CDKN2A, FLT1, PTEN, LGALS3, GFAP
6	glucose32	9.4	BRAF, LGALS1, S100B, MKI67, MGMT, CDK4
7	crcs32	9.3	KRAS, DAPK1, PTEN, TP53, HRAS, CDKN2A
8	formaldehyde32 18	10.1	SYP, LGALS3, LAMP1, S100B, CDKN3, MKI67
9	methionine32	9.1	TIMP3, LGALS1, THBS1, S100B, HRAS, GJA1
10	bromodeoxyuridine32	9.0	PDGFRB, DCX, MKI67, CDK4, S100B, CDKN1A
11	p00232	8.9	MKI67, MGMT, ERBB3, TP73, TNC, CTSD
12	tgf beta132	8.8	TIMP3, THBS1, TIMP1, CDKN1A, PDGFRA, CDK4
13	etoposide32 42 9 9	11.7	LGALS1, TIMP1, CTSD, TP53, CDKN1A, S100B
14	5-aza-2deoxycytidine32	8.7	TIMP1, THBS1, CDKN2A, MGMT, TP53, TP73
15	ly29400232	8.7	THBS1, VEGFA, CDKN3, HRAS, GJA1, KRAS
16	12-o-tetradecanoylphorbol 13-acetate32	8.7	ADM, BRAF, CDKN1A, CDK4, TIMP3, MGMT
17	fatty acid32	8.6	ERBB3, TP73, PTEN, NF1, IDH1, APOD
18	matrigel32	8.5	TNC, LGALS3, S100A4, FLT1, GJA1, PDGFRB
19	wortmannin32 42	9.5	KRAS, BRAF, S100B, CDKN1A, HRAS, ERBB3
20	agar32	8.4	HRAS, GJA1, ERBB3, ERBB4, CTSD, NRAS
21	thymidine32 18	9.3	S100B, KDR, CDKN1A, CDK4, MKI67, MGMT
22	calcium32 9 18 9	11.0	BRAF, LGALS1, LGALS3, LAMP1, S100A1, S100A2
23	gemcitabine32 34 9 9	11.0	KDR, CDKN1A, TP73, VEGFA, HRAS, ERBB3
24	imatinib32 34 9 9	11.0	EGFR, KRAS, PDGFRB, PDGFRA, PTEN, TP73
25	rapamycin32 42	8.9	FLT1, HRAS, ERBB3, NF1, PDGFRA, PDGFRB
26	erlotinib32 34 9 9	10.8	ERBB3, EGFR, PTEN, PDGFRB, CDKN3, KDR
27	cysteine32	7.8	NF1, PDGFRB, GFAP, TIMP1, TIMP3, THBS1
28	oxygen32 18	8.7	PDGFA, PDGFRB, GFAP, TIMP3, THBS1, ADM
29	oligonucleotide32	7.6	TP53, HLA-DPB1, ERBB3, HRAS, HTRA1, APOD
30	cetuximab32 34 9 9	10.6	EGFR, BRAF, VEGFA, KDR, CDKN3, ERBB3
31	trastuzumab32 34 9 9	10.5	PTEN, ERBB4, ERBB3, CDK4, CDKN3, KDR
32	lipid32	7.3	TP73, APOD, NES, TNC, ERBB4, ERBB3
33	phosphotyrosine32	7.3	PDGFRA, GJA1, ERBB3, ERBB4, PTEN, PDGFRB
34	5fluorouracil32	7.3	THBS1, EGFR, KRAS, CTSD, MKI67, CDKN1A
35	gefitinib32 34 9 9	10.2	KDR, VEGFA, EGFR, KRAS, PDGFRB, CDK4
36	testosterone32 9 18 9	10.2	TNR, ERBB3, GJA1, ALDH1A1, PTEN, APOD
37	tamoxifen32 34 9 9	9.9	VEGFA, THBS1, EGFR, CTSD, PTEN, TP53
38	doxorubicin32 34 9 9	9.9	FLT1, PTEN, KDR, VEGFA, THBS1, CDKN1A
39	cycloheximide32	6.6	TNC, PTEN, CTSD, CDK4, EGFR, GFAP
40	retinoic acid32 42 18	8.3	NES, ADM, KDR, LGALS3, S100A4, S100A6
41	genistein32 9 18 9	9.3	VEGFA, THBS1, SYP, TIMP3, TIMP1, GFAP
42	paclitaxel32 34 9 9	9.1	PDGFRB, KRAS, EGFR, GFAP, TIMP1, THBS1
43	phosphatidylinositol32	6.1	BRAF, KDR, LGALS3, LGALS8, CDKN3, CDK4
44	estrogen32	6.1	PDGFRA, PDGFA, NF1, TNC, NES, SYP
45	progesterone32 42 9 18 9	9.7	CDKN2A, CDK4, MKI67, FLT1, MGMT, APOD
46	serine32	5.3	BRAF, KDR, LGALS1, LGALS3, S100B, CDKN1A
47	cisplatin32 34 9 9	7.9	FLT1, MGMT, MBP, ALDH1A1, HRAS, GJA1
48	paraffin32	4.7	CDKN1A, CDKN2A, CDK4, MKI67, FLT1, MGMT
49	vegf32	4.3	BRAF, TNC, PTEN, CTSD, PDGFA, PDGFRA
50	tyrosine32	3.6	ERBB3, TIMP3, THBS1, SYP, NES, ADM

Cellular components related to pilocytic astrocytoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix	GO:031012	9.7	THBS1, CTSD, TNC, HTRA1, MATN2, TIMP3
2	platelet alpha granule lumen	GO:031093	9.4	VEGFA, PDGFA, TIMP1, THBS1
3	extracellular space	GO:005615	7.7	HTRA1, APOD, FLT1, LGALS8, LGALS1, ERBB3
4	cytosol	GO:005829	6.7	TP53, TUBG2, ERBB4, GJA1, HRAS, DOCK6
5	cytoplasm	GO:005737	5.0	TP53, TNR, PTEN, ERBB4, DAPK1, OLIG2
6	nucleus	GO:005634	4.2	PML, TP73, TP53, ERBB4, ERBB3, HRAS

Biological processes related to pilocytic astrocytoma according to GeneDecks:

(show all 49)

id	Name	GO ID	Score	Top Affiliating Genes
1	activation of MAPKK activity	GO:000186	10.8	NRAS
2	negative regulation of focal adhesion assembly	GO:051895	10.7	THBS1, PTEN, APOD
3	regulation of cell-matrix adhesion	GO:001952	10.6	TSC1, NF1, ONECUT2
4	central nervous system development	GO:007417	10.5	NES, S100B, MBP, TP53, PTEN, TIMP3
5	positive regulation of phospholipase C activity	GO:010863	10.5	PDGFRA, FLT1, PDGFRB
6	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	GO:042771	10.4	PML, TP73, TP53, HIPK2
7	positive regulation of reactive oxygen species metabolic process	GO:2000379	10.4	THBS1, PDGFRB, TP53, CDKN1A
8	negative regulation of cell-matrix adhesion	GO:001953	10.3	THBS1, CDKN2A, NF1
9	positive regulation of Rac protein signal transduction	GO:035022	10.2	HRAS, NRAS, KRAS
10	regulation of synaptic transmission, GABAergic	GO:032228	10.2	KRAS, NF1, NRAS, HRAS
11	regulation of long-term neuronal synaptic plasticity	GO:048169	10.1	HRAS, NRAS, NF1, SYP, KRAS
12	regulation of DNA biosynthetic process	GO:2000278	10.1	CDKN1A, PDGFA
13	striated muscle cell differentiation	GO:051146	10.1	HRAS, KRAS, NRAS
14	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	GO:038091	10.1	VEGFA, PDGFRA, PDGFRB
15	visual learning	GO:008542	10.1	HRAS, NF1, NRAS, KRAS
16	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.0	KDR, FLT1, ERBB3, PDGFA, PDGFRA, PDGFRB
17	replicative senescence	GO:090399	9.9	CDKN1A, TP53, CDKN2A
18	positive regulation of phosphatidylinositol 3-kinase activity	GO:043552	9.9	ERBB4, FLT1, PDGFRB, PDGFRA
19	negative regulation of neuron apoptotic process	GO:043524	9.8	HRAS, KRAS, BRAF, ERBB3, NRAS
20	positive regulation of focal adhesion assembly	GO:051894	9.8	KDR, TSC1, VEGFA
21	regulation of peptidyl-tyrosine phosphorylation	GO:050730	9.8	PDGFA, PDGFRB, EGFR
22	induction of apoptosis by intracellular signals	GO:008629	9.8	CDKN1A, HRAS, TP53, HIPK2
23	vascular endothelial growth factor receptor signaling pathway	GO:048010	9.7	KDR, VEGFA, FLT1, PDGFRA, PDGFRB
24	cellular response to vascular endothelial growth factor stimulus	GO:035924	9.7	FLT1, VEGFA, KDR
25	positive regulation of angiogenesis	GO:045766	9.7	THBS1, HIPK2, FLT1, KDR, ADM, VEGFA
26	peptidyl-tyrosine phosphorylation	GO:018108	9.6	KDR, FLT1, ERBB4, PDGFRA, PDGFRB
27	cellular senescence	GO:090398	9.6	HRAS, CDKN2A, CDKN1A
28	response to hypoxia	GO:001666	9.5	THBS1, NF1, FLT1, VEGFA, PML, ADM
29	heart development	GO:007507	9.5	GJA1, NF1, PTEN, ERBB3, ADM, ERBB4
30	cell fate commitment	GO:045165	9.5	KDR, ERBB4, PML, ONECUT2
31	platelet degranulation	GO:002576	9.5	PDGFA, LAMP2, THBS1, TIMP1, VEGFA
32	digestive tract morphogenesis	GO:048546	9.5	EGFR, SOX10, TP73
33	positive regulation of DNA replication	GO:045740	9.4	EGFR, PDGFRA, HRAS, PDGFA
34	Ras protein signal transduction	GO:007265	9.4	NF1, CDKN2A, TP53, HRAS, KRAS, NRAS
35	positive regulation of fibroblast proliferation	GO:048146	9.4	S100A6, CDK4, PDGFA, PDGFRA, EGFR, CDKN1A
36	response to drug	GO:042493	9.3	MGMT, LGALS1, APOD, NES, CDKN1A, THBS1
37	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.3	PDGFRA, PDGFA, ERBB4, PDGFRB, KDR, BRAF
38	cell migration	GO:016477	9.3	PTEN, PDGFRB, THBS1, FLT1, ERBB4
39	MAPK cascade	GO:000165	9.3	EGFR, HRAS, KRAS, NF1, NRAS
40	positive regulation of MAP kinase activity	GO:043406	9.1	VEGFA, FLT1, PDGFA, KRAS, EGFR, PDGFRB
41	cell cycle arrest	GO:007050	9.1	HRAS, CDKN1A, CDKN2A, CDKN3, TP53, TP73
42	blood coagulation	GO:007596	8.7	DOCK6, THBS1, TIMP1, KRAS, NRAS, TP53
43	axon guidance	GO:007411	8.7	KRAS, RANBP9, TNR, SRGAP2, HRAS, DCX
44	protein autophosphorylation	GO:046777	8.5	KDR, FLT1, EGFR, PDGFRB, PDGFRA, DAPK1
45	cell proliferation	GO:008283	8.4	EGFR, SRGAP2, PTEN, TP53, ERBB4, HRAS
46	negative regulation of cell proliferation	GO:008285	8.2	ERBB4, GJA1, HRAS, CDKN3, CDKN2A, CDKN1A
47	positive regulation of cell migration	GO:030335	8.1	ONECUT2, FLT1, THBS1, EGFR, PDGFRB, VEGFA
48	negative regulation of apoptotic process	GO:043066	7.5	TIMP1, TP53, PTEN, EGFR, THBS1, SOX10
49	positive regulation of cell proliferation	GO:008284	6.8	VEGFA, CDK4, TIMP1, ADM, HRAS, ERBB4

Molecular functions related to pilocytic astrocytoma according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	S100 protein binding	GO:044548	10.2	S100A1, S100A6, S100B
2	vascular endothelial growth factor-activated receptor activity	GO:005021	10.0	PDGFRB, PDGFRA, KDR, FLT1
3	vascular endothelial growth factor binding	GO:038085	10.0	KDR, PDGFRA, PDGFRB
4	platelet-derived growth factor binding	GO:048407	9.9	PDGFRA, PDGFA, PDGFRB
5	platelet-derived growth factor receptor binding	GO:005161	9.8	VEGFA, PDGFA, PDGFRA, PDGFRB
6	calcium ion binding	GO:005509	9.5	S100A4, THBS1, SYP, BRAF, S100A1, S100A2
7	identical protein binding	GO:042802	9.2	SOX10, EGFR, S100A1, S100A4, S100B, THBS1
8	receptor signaling protein tyrosine kinase activity	GO:004716	8.6	ERBB4, KDR, EGFR
9	transmembrane receptor protein tyrosine kinase activity	GO:004714	8.5	ERBB4, ERBB3, EGFR, FLT1, KDR, PDGFRA
10	protein tyrosine kinase activity	GO:004713	8.4	ERBB3, ERBB4, EGFR, KDR, PDGFRB
11	protein homodimerization activity	GO:042803	8.2	ERBB3, PML, IDH1, OLIG2, SRGAP2, PDGFA
12	protein binding	GO:005515	3.1	PML, HRAS, MATN2, APOD, FLT1, MKI67