MCID: PLC011
MIFTS: 57

Pilocytic Astrocytoma malady

Rare diseases, Neuronal diseases, Cancer diseases categories

Summaries for Pilocytic Astrocytoma

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44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Pilocytic astrocytoma is an oftenĀ benign, slow-growing tumor of the brain or spinal cord. the tumor may be in the form of a cyst and usually does not spread to nearby tissues. symptoms vary depending upon the size and location of the tumor. most symptoms result from increased pressure on the brain and include headaches, nausea, vomiting, balance problems, and vision abnormalities. the underlying cause of a pilocytic astrocytoma is unknown. it most commonly occurs in children and young adults, and in people with neurofibromatosis type 1 (nf1), li-fraumeni syndrome, and tuberous sclerosis. this type of tumor can often be cured with surgery. last updated: 8/9/2013

MalaCards: Pilocytic Astrocytoma, also known as juvenile pilocytic astrocytoma, is related to astrocytoma and neurofibromatosis. An important gene associated with Pilocytic Astrocytoma is KIAA1549 (KIAA1549), and among its related pathways are Renal cell carcinoma and Signalling to ERKs. The compounds regorafenib and sorafenib have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and cerebellum, and related mouse phenotypes are pigmentation and embryogenesis.

Wikipedia:66 Pilocytic astrocytoma or juvenile pilocytic astrocytoma or cystic cerebellar astrocytoma (and its... more...

Aliases & Classifications for Pilocytic Astrocytoma

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44NIH Rare Diseases, 63UMLS, 11DISEASES, 46Novoseek, 50Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

50
pilocytic astrocytoma:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

pilocytic astrocytoma 44 11 46 50 63
juvenile pilocytic astrocytoma 44 63


External Ids:

SNOMED-CT via Orphanet60 128854008
UMLS via Orphanet64 C0334583

Related Diseases for Pilocytic Astrocytoma

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18GeneCards, 19GeneDecks
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Diseases in the Pilocytic Astrocytoma family:

Juvenile Pilocytic Astrocytoma

Diseases related to Pilocytic Astrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 154)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma31.7IDH1, THBS1, GFAP, TNC, FGFR1, S100B
2neurofibromatosis31.1KRAS, S100B, RAF1
3oligodendroglioma30.9GFAP, BRAF
4medulloblastoma30.8GFAP, TIMP3, NES, NTRK2, SYP, S100B
5anaplastic astrocytoma30.7PDGFRB, LGALS3, NES, APOD, TNC, GFAP
6meningioma30.7S100B, PDGFRB, SYP, TNC, GFAP
7dysembryoplastic neuroepithelial tumor30.7KIAA1549, SYP
8glioblastoma multiforme30.5THBS1, GFAP, TNC, NES, PDGFRB
9ependymoma30.5GFAP, TIMP3, DCX, NES, SYP, S100B
10gliosarcoma30.4PDGFRB, GFAP
11ganglioglioma30.4S100B, SYP, NTRK2, DCX, APOD, GFAP
12myxopapillary ependymoma30.4S100B, GFAP
13choroid plexus carcinoma30.4S100B, GFAP
14hemangioblastoma30.4GFAP, NES, SYP, S100B
15leukemia30.4IDH1, NES, PDGFRB, RAF1, KRAS, FGFR1
16noonan syndrome30.3BRAF, RAF1, KRAS
17anaplastic oligodendroglioma30.3GFAP, LGALS3
18adenocarcinoma29.8THBS1, TNC, TIMP3, FGFR1, KRAS, RAF1
19malignant glioma29.7FGFR1, S100B, RAF1, PDGFRB, SYP, NTRK2
20juvenile pilocytic astrocytoma11.0
21pilocytic astrocytoma of cerebellum10.5
22childhood pilocytic astrocytoma10.5
23cerebritis10.4
24pilomyxoid astrocytoma10.4
25diffuse astrocytoma10.4
26autism spectrum disorder10.3
27cervicitis10.3
28craniopharyngioma10.3
29diencephalic syndrome10.3
30hemifacial spasm10.3
31tremor10.3
32endotheliitis10.3
33pituicytoma10.3
34siderosis10.2
35choroiditis10.2
36sensorineural hearing loss10.2
37trigonitis10.2
38gonadoblastoma10.2
39arteriovenous malformation10.2
40frasier syndrome10.2
41pleomorphic xanthoastrocytoma10.2
42obstructive hydrocephalus10.2
43albright's hereditary osteodystrophy10.2
44silver-russell syndrome10.2
45amblyopia10.2
46basal cell carcinoma10.2
47eating disorder10.2
48ectropion10.2
49esotropia10.2
50hydrocephalus10.2

Graphical network of the top 20 diseases related to Pilocytic Astrocytoma:



Diseases related to pilocytic astrocytoma

Symptoms for Pilocytic Astrocytoma

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Drugs & Therapeutics for Pilocytic Astrocytoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Pilocytic Astrocytoma

Drug clinical trials:

Search ClinicalTrials for Pilocytic Astrocytoma

Search NIH Clinical Center for Pilocytic Astrocytoma

Search CenterWatch for Pilocytic Astrocytoma

Genetic Tests for Pilocytic Astrocytoma

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Anatomical Context for Pilocytic Astrocytoma

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34MalaCards
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MalaCards organs/tissues related to Pilocytic Astrocytoma:

34
Brain, Spinal cord, Cerebellum, Pineal, Tongue, Temporal lobe, Ovary, Endothelial, Hypothalamus, Pituitary, Retina, Breast, Bone, Medulla oblongata

Animal Models for Pilocytic Astrocytoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Pilocytic Astrocytoma:

38 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.6KRAS, BRAF, SOX10, TIMP3
2MP:00053809.0SOX10, BRAF, NES, PDGFRB, RAF1, KRAS
3MP:00053678.9THBS1, TIMP3, BRAF, LGALS3, PDGFRB, KRAS
4MP:00053908.8THBS1, BRAF, LGALS3, NTRK2, PDGFRB, RAF1
5MP:00053888.8THBS1, TIMP3, SOX10, BRAF, LGALS3, NTRK2
6MP:00053698.7THBS1, GFAP, TIMP3, BRAF, PDGFRB, RAF1
7MP:00053798.7THBS1, TIMP3, SOX10, BRAF, NTRK2, PDGFRB
8MP:00053818.6THBS1, GFAP, SOX10, BRAF, LGALS3, PDGFRB
9MP:00053918.6THBS1, GFAP, TIMP3, BRAF, NTRK2, PDGFRB
10MP:00053898.3THBS1, DCX, BRAF, LGALS3, NTRK2, PDGFRB
11MP:00028738.3GFAP, TNC, SOX10, BRAF, NTRK2, SYP
12MP:00053978.3THBS1, IDH1, TIMP3, BRAF, LGALS3, PDGFRB
13MP:00053858.2THBS1, GFAP, APOD, TIMP3, BRAF, LGALS3
14MP:00107718.1BRAF, SOX10, TIMP3, THBS1, LGALS3, PDGFRB
15MP:00053878.1THBS1, IDH1, GFAP, TIMP3, BRAF, LGALS3
16MP:00053787.9SOX10, DCX, TIMP3, GFAP, THBS1, BRAF
17MP:00053847.8BRAF, SOX10, TIMP3, GFAP, THBS1, NES
18MP:00053867.7SOX10, DCX, TIMP3, APOD, TNC, GFAP
19MP:00036317.4FGFR1, GFAP, TNC, APOD, DCX, SOX10
20MP:00053767.4TIMP3, APOD, TNC, GFAP, IDH1, THBS1
21MP:00107687.2SOX10, DCX, TIMP3, APOD, GFAP, THBS1

Publications for Pilocytic Astrocytoma

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53PubMed
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Articles related to Pilocytic Astrocytoma:

(show top 50)    (show all 288)
idTitleAuthorsYear
1
Transformation of adult cerebellar pilocytic astrocytoma to glioblastoma. (23884731)
2013
2
Metachronous, multicentric glioma of pilocytic astrocytoma with oligodendroglioma-like component and oligodendroglioma through distinct genetic aberrations. (23082883)
2013
3
Transsphenoidal removal of intrasellar pilocytic astrocytoma. (24308951)
2013
4
Cerebellar metastasis from serous adenocarcinoma of the ovary mimicking pilocytic astrocytoma. (23293670)
2012
5
Juvenile pilocytic astrocytoma in association with arteriovenous malformation. (22681727)
2012
6
MAPK pathway activation in pilocytic astrocytoma. (22159586)
2012
7
Pilocytic astrocytoma with extensive psammomatous calcification in the lateral ventricle: a case report. (22167267)
2012
8
Vascular endothelial growth factor receptor 2 (VEGFR-2) signalling activity in paediatric pilocytic astrocytoma is restricted to tumour endothelial cells. (21208252)
2011
9
Primary cerebellar pilocytic astrocytoma with anaplastic features in a patient with neurofibromatosis type 1 - case report - . (21515958)
2011
10
An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice. (21403401)
2011
11
Proteomics studies of childhood pilocytic astrocytoma. (21466243)
2011
12
Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. (21274720)
2011
13
Magnetic resonance imaging features of pilocytic astrocytoma of the brain mimicking high-grade gliomas. (20657231)
2010
14
Management of intramedullary cystic pilocytic astrocytoma with rhenium-186 intracavitary irradiation: case report. (20404673)
2010
15
Acute v pattern esotropia without abduction deficit, secondary to a posterior fossa pilocytic astrocytoma. (19645405)
2009
16
Somatic mitochondrial mutations in pilocytic astrocytoma. (19480934)
2009
17
Histopathologic predictors of pilocytic astrocytoma event-free survival. (19271226)
2009
18
Real-time quantitative polymerase chain reaction (qPCR) analysis with fluorescence resonance energy transfer (FRET) probes reveals differential expression of the four ERBB4 juxtamembrane region variants between medulloblastoma and pilocytic astrocytoma. (19017278)
2009
19
Long-term functional outcome of surgical treatment of juvenile pilocytic astrocytoma of the cerebellum in children. (19418058)
2009
20
Diurnally fluctuating frontal dysequilibrium secondary to a pineal pilocytic astrocytoma: is this symptom associated with a check-valve mechanism in a pineal region tumor? (18972117)
2009
21
Cerebellar pilocytic astrocytoma presenting with intratumor bleeding, subarachnoid hemorrhage, and subdural hematoma. (18629510)
2009
22
Calcified pilocytic astrocytoma of the medulla mimicking a brainstem "stone". (19253601)
2008
23
Pilocytic astrocytoma with spontaneous intracranial hemorrhages in an elderly adult. (16621238)
2007
24
Occurrence of a spinal anaplastic pilocytic astrocytoma and a supratentorial PNET in an adolescent. (18090931)
2007
25
Paired overexpression of ErbB3 and Sox10 in pilocytic astrocytoma. (16896310)
2006
26
Large cystic cavernous angioma of the cerebellum mimicking pilocytic astrocytoma. (16821089)
2006
27
Disseminated pilocytic astrocytoma involving brain stem and diencephalon: a history of atypical eating disorder and diagnostic delay. (16598421)
2006
28
Radical resection for intrinsic midbrain pilocytic astrocytoma: report of two cases. (15309583)
2005
29
No aberrant methylation of neurofibromatosis 1 gene (NF1) promoter in pilocytic astrocytoma in childhood. (15770836)
2005
30
Exophytic pilocytic astrocytoma of the brain stem in an adult with encasement of the caudal cranial nerve complex (IX-XII): presurgical anatomical neuroimaging using MRI. (14740164)
2004
31
Juvenile pilocytic astrocytoma 'pilomyxoid variant' with spinal metastases. (15261239)
2004
32
Juvenile pilocytic astrocytoma. (12880155)
2003
33
Mutational and expression analysis of the NF1 gene argues against a role as tumor suppressor in sporadic pilocytic astrocytomas. (12387455)
2002
34
Case report: Hemispheric juvenile pilocytic astrocytoma with extreme exophytic growth. (11384146)
2001
35
Pilocytic astrocytomas do not show most of the genetic changes commonly seen in diffuse astrocytomas. (11119125)
2000
36
Involution of diencephalic pilocytic astrocytoma after partial resection. Report of two cases in adults. (10969949)
2000
37
Dorsally exophytic brain stem tumors: total removal of a medullary pilocytic astrocytoma in child. Clinicopathological considerations and case report. (10864393)
1999
38
Low grade pilocytic astrocytoma presenting as a spontaneous intracerebral haemorrhage in a child. (11013653)
1998
39
Hypothalamic pilocytic astrocytoma presenting with intratumoral and subarachnoid hemorrhage. (9414929)
1997
40
Expression of vascular endothelial growth factor and its receptors in pilocytic astrocytoma. (9255258)
1997
41
Management of pilocytic astrocytoma. (9007882)
1996
42
Transient amnestic syndrome after spontaneous haemorrhage into a hypothalamic pilocytic astrocytoma. (7608691)
1995
43
The significance of atypia and histologic malignancy in pilocytic astrocytoma of the cerebellum: a clinicopathologic and flow cytometric study. (7930411)
1994
44
Fatal hemorrhage in a cerebral pilocytic astrocytoma-adult type. (1882644)
1991
45
Metastatic juvenile pilocytic astrocytoma. Case report. (1941128)
1991
46
Treatment results of juvenile pilocytic astrocytoma. (3392563)
1988
47
Anaplastic evolution of childhood optico-hypothalamic pilocytic astrocytoma: report of an autopsy case. (3208464)
1988
48
Cerebral pilocytic astrocytoma. (4016701)
1985
49
Pilocytic astrocytoma of the optic nerve with hemorrhage and extreme cystic degeneration. (7304696)
1981
50
Malignant evolution of childhood chiasmal pilocytic astrocytoma. (944389)
1976

Variations for Pilocytic Astrocytoma

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Expression for genes affiliated with Pilocytic Astrocytoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pilocytic Astrocytoma

Search GEO for disease gene expression data for Pilocytic Astrocytoma.

Pathways for genes affiliated with Pilocytic Astrocytoma

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51PathCards, 31KEGG, 56Reactome, 61Thomson Reuters, 55R&D Systems, 54QIAGEN, 39NCBI BioSystems Database, 52PharmGKB, 58SinoBiological, 62Tocris Bioscience, 5Cell Signaling Technology
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Pathways related to Pilocytic Astrocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0KRAS, RAF1, BRAF
2
Show member pathways
10.0BRAF, RAF1, KRAS
3
Show member pathways
10.0BRAF, RAF1, KRAS
410.0BRAF, RAF1, KRAS
510.0BRAF, RAF1, KRAS
610.0BRAF, RAF1, KRAS
7
Show member pathways
10.0FGFR1, KRAS, RAF1
89.8RAF1, PDGFRB, BRAF
9
Show member pathways
9.8FGFR1, KRAS, RAF1, BRAF
109.8FGFR1, PDGFRB, NTRK2
119.7FGFR1, TNC, THBS1
12
Show member pathways
MAPK Cascade39
Immune response Oncostatin M signaling via MAPK in human cells61
Oncostatin M Signaling Pathway39
9.7KRAS, RAF1, BRAF, TIMP3
13
Show member pathways
9.7FGFR1, KRAS, RAF1, TIMP3
14
Show member pathways
Transcription Receptor mediated HIF regulation61
Development CNTF receptor signaling61
Class IB PI3K non-lipid kinase events39
ErbB2/ErbB3 signaling events39
Development Growth hormone signaling via PI3K AKT and MAPK cascades61
Translation Regulation activity of EIF261
Regulation of lipid metabolism Insulin signaling generic cascades61
Transcription PPAR Pathway61
Cell adhesion PLAU signaling61
Translation Regulation activity of EIF4F61
9.7KRAS, RAF1, PDGFRB, BRAF
15
Show member pathways
9.7KRAS, RAF1, PDGFRB, BRAF
16
Show member pathways
Development EDNRB signaling61
Development ACM2 and ACM4 activation of ERK61
Cell adhesion Integrin inside out signaling61
Development G Proteins mediated regulation MARK ERK signaling61
Signal transduction IP3 signaling61
Development Angiotensin signaling via PYK261
Development EPO induced MAPK pathway61
9.7KRAS, RAF1, PDGFRB, BRAF
17
Show member pathways
9.6FGFR1, KRAS, PDGFRB, NTRK2
189.6NTRK2, PDGFRB, KRAS, FGFR1
19
Show member pathways
9.6NTRK2, PDGFRB, RAF1, FGFR1
209.5THBS1, RAF1, KRAS, FGFR1
21
Show member pathways
9.5DCX, SRGAP3, RAF1, KRAS, FGFR1
22
Show member pathways
9.5BRAF, PDGFRB, RAF1, KRAS, FGFR1
239.5FGFR1, KRAS, RAF1, PDGFRB, BRAF
24
Show member pathways
9.5FGFR1, KRAS, RAF1, PDGFRB, BRAF
259.5FGFR1, PDGFRB, TIMP3, TNC
26
Show member pathways
Development EGFR signaling via PIP361
Development PDGF signaling via MAPK cascades61
Apoptosis and survival Anti apoptotic action of membrane bound ESR161
Signaling of Hepatocyte Growth Factor Receptor39
Development EGFR signaling via small GTPases61
Development Neurotrophin family signaling61
Apoptosis and survival NGF signaling pathway61
Apoptosis and survival Role of CDK5 in neuronal death and survival61
9.5BRAF, NTRK2, PDGFRB, RAF1, KRAS
27
Show member pathways
9.5FGFR1, RAF1, PDGFRB, NTRK2, BRAF
28
Show member pathways
9.5FGFR1, RAF1, PDGFRB, NTRK2, BRAF
29
Show member pathways
9.3TIMP3, NTRK2, PDGFRB, RAF1, FGFR1
30
Show member pathways
9.3TIMP3, NTRK2, PDGFRB, RAF1, FGFR1
31
Show member pathways
9.3TIMP3, NTRK2, PDGFRB, RAF1, FGFR1
32
Show member pathways
MAPK signaling pathway39
9.3BRAF, NTRK2, PDGFRB, RAF1, KRAS, FGFR1
339.2FGFR1, KRAS, RAF1, PDGFRB, BRAF, IDH1
34
Show member pathways
Integrin-mediated cell adhesion39
Focal Adhesion39
9.2THBS1, TNC, BRAF, PDGFRB, RAF1
35
Show member pathways
9.2TIMP3, BRAF, NTRK2, PDGFRB, RAF1, FGFR1
36
Show member pathways
9.2TIMP3, BRAF, NTRK2, PDGFRB, RAF1, FGFR1
37
Show member pathways
9.2TIMP3, BRAF, NTRK2, PDGFRB, RAF1, FGFR1
38
Show member pathways
9.2TIMP3, BRAF, NTRK2, PDGFRB, RAF1, FGFR1
399.1THBS1, TIMP3, BRAF, RAF1, KRAS, FGFR1
40
Show member pathways
9.1THBS1, BRAF, PDGFRB, RAF1, KRAS, FGFR1
41
Show member pathways
Signaling Pathways in Glioblastoma39
9.1THBS1, BRAF, PDGFRB, RAF1, KRAS, FGFR1
429.0THBS1, TNC, PDGFRB, RAF1, KRAS, FGFR1
43
Show member pathways
9.0GFAP, PDGFRB, RAF1, S100B, KRAS, FGFR1
44
Show member pathways
9.0TNC, TIMP3, BRAF, NTRK2, PDGFRB, RAF1
458.9GFAP, TNC, DCX, NTRK2, SYP, S100B
468.9THBS1, TNC, TIMP3, PDGFRB, RAF1, KRAS
47
Show member pathways
8.9TIMP3, DCX, BRAF, NTRK2, PDGFRB, RAF1
48
Show member pathways
8.9THBS1, BRAF, NTRK2, PDGFRB, RAF1, KRAS
49
Show member pathways
8.5GFAP, TNC, TIMP3, SOX10, BRAF, NTRK2
50
Show member pathways
8.1THBS1, GFAP, BRAF, SRGAP3, NTRK2, PDGFRB

Compounds for genes affiliated with Pilocytic Astrocytoma

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Sources:
52PharmGKB, 12DrugBank, 46Novoseek, 30IUPHAR, 25HMDB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Pilocytic Astrocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 107)
idCompoundScoreTop Affiliating Genes
1regorafenib52 1210.9BRAF, PDGFRB, RAF1, KRAS, FGFR1
2sorafenib46 52 1211.8BRAF, PDGFRB, RAF1, FGFR1
3o6-methylguanine469.7KRAS, BRAF, TIMP3, THBS1
4s 100469.7S100B, SYP, GFAP
5streptozotocin469.7GFAP, NES, SYP, RAF1
6kainate46 3010.5GFAP, DCX, NES, NTRK2, SYP
7imatinib46 52 1211.5BRAF, PDGFRB, RAF1, S100B, KRAS, FGFR1
8chondroitin sulfate46 2510.5THBS1, GFAP, TNC, TIMP3, FGFR1
9choline46 25 1211.4GFAP, NES, SYP, RAF1, S100B
10gaba469.3GFAP, TNC, NES, NTRK2, SYP, S100B
11formaldehyde46 2510.2S100B, SYP, LGALS3, TNC, GFAP
12bromodeoxyuridine469.2GFAP, DCX, NES, PDGFRB, S100B, FGFR1
13forskolin46 52 1211.2GFAP, BRAF, NTRK2, SYP, RAF1, S100B
14pd 98,059469.2THBS1, GFAP, TIMP3, BRAF, NTRK2, RAF1
15dopamine46 30 25 1212.1GFAP, NES, NTRK2, SYP, RAF1, S100B
16agar469.0THBS1, GFAP, BRAF, LGALS3, PDGFRB, RAF1
17cisplatin46 52 62 1212.0GFAP, BRAF, LGALS3, NTRK2, SYP, PDGFRB
18hematoxylin468.9GFAP, LGALS3, SYP, S100B
19gtp46 309.9THBS1, BRAF, SYP, RAF1, S100B, KRAS
20phosphoinositide468.9THBS1, TNC, BRAF, LGALS3, NTRK2, PDGFRB
21genistein46 30 62 3 25 1213.9THBS1, GFAP, TIMP3, SYP, PDGFRB, RAF1
22methionine468.9THBS1, GFAP, TIMP3, PDGFRB, S100B, FGFR1
23fatty acid468.9IDH1, APOD, BRAF, LGALS3, S100B, KRAS
24glutamine468.8IDH1, GFAP, TIMP3, LGALS3, SYP, RAF1
25ly294002468.8THBS1, TNC, TIMP3, BRAF, NTRK2, PDGFRB
26heparin46 30 25 1211.8THBS1, TNC, TIMP3, LGALS3, RAF1, S100B
27paclitaxel46 52 1210.7THBS1, GFAP, SOX10, BRAF, PDGFRB, RAF1
28h2o2468.6THBS1, TNC, LGALS3, NTRK2, SYP, PDGFRB
29dexamethasone46 52 30 1211.5THBS1, GFAP, TNC, TIMP3, SYP, RAF1
30alanine468.5THBS1, GFAP, BRAF, LGALS3, NTRK2, PDGFRB
31matrigel468.5THBS1, GFAP, TNC, TIMP3, BRAF, NES
32nitric oxide46 25 1210.5NES, LGALS3, NTRK2, SYP, S100B, FGFR1
33wortmannin468.4THBS1, TNC, TIMP3, BRAF, LGALS3, PDGFRB
34threonine468.4THBS1, GFAP, BRAF, LGALS3, NTRK2, PDGFRB
35phosphatidylinositol468.4BRAF, TIMP3, TNC, THBS1, LGALS3, NTRK2
36oligonucleotide468.4TIMP3, APOD, TNC, THBS1, BRAF, LGALS3
37oxygen46 259.2THBS1, GFAP, TIMP3, NES, LGALS3, NTRK2
38glucose468.2THBS1, GFAP, APOD, TIMP3, BRAF, NES
39testosterone46 62 25 1211.2THBS1, GFAP, APOD, TIMP3, NTRK2, SYP
40glutamate468.1IDH1, GFAP, TNC, TIMP3, BRAF, NES
41cysteine468.0THBS1, GFAP, TNC, TIMP3, LGALS3, SYP
42paraffin467.7KRAS, S100B, PDGFRB, SYP, LGALS3, NES
43progesterone46 30 62 25 1211.6SYP, LGALS3, NES, BRAF, TIMP3, APOD
44serine467.6BRAF, DCX, TNC, GFAP, THBS1, LGALS3
45calcium46 52 25 1210.4THBS1, IDH1, GFAP, TNC, TIMP3, DCX
46tyrosine467.3NES, BRAF, TIMP3, TNC, GFAP, THBS1
47lipid467.3BRAF, TIMP3, APOD, TNC, GFAP, THBS1
48retinoic acid46 258.1TNC, GFAP, THBS1, APOD, RAF1, PDGFRB
49estrogen467.1FGFR1, KRAS, S100B, RAF1, PDGFRB, SYP
50vegf467.1FGFR1, TIMP3, TNC, GFAP, THBS1, DCX

GO Terms for genes affiliated with Pilocytic Astrocytoma

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Sources:
17Gene Ontology
See all sources

Cellular components related to Pilocytic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1presynaptic active zoneGO:04878610.0SYP, NTRK2
2extracellular matrixGO:0310129.1LGALS3, TIMP3, TNC, THBS1
3cytosolGO:0058298.5IDH1, GFAP, DCX, BRAF, SRGAP3, NTRK2

Biological processes related to Pilocytic Astrocytoma according to GeneCards/GeneDecks:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1peripheral nervous system axon regenerationGO:01401210.3TNC, APOD
2activation of MAPKK activityGO:00018610.3KRAS, RAF1, BRAF
3positive regulation of phospholipase C activityGO:01086310.2FGFR1, PDGFRB
4MAPK cascadeGO:00016510.2RAF1, KRAS, FGFR1
5positive regulation of MAP kinase activityGO:04340610.2FGFR1, KRAS, PDGFRB
6positive regulation of phosphatidylinositol 3-kinase signalingGO:01406810.1FGFR1, PDGFRB, NTRK2
7positive regulation of gene expressionGO:01062810.1TNC, BRAF, NTRK2, KRAS
8negative regulation of neuron apoptotic processGO:04352410.1BRAF, NES, NTRK2, KRAS
9negative regulation of focal adhesion assemblyGO:05189510.1APOD, THBS1
10oligodendrocyte differentiationGO:04870910.1NTRK2, SOX10
11wound healingGO:04206010.1RAF1, PDGFRB, TNC
12long-term synaptic potentiationGO:06029110.0S100B, NTRK2, GFAP
13positive regulation of calcium ion importGO:09028010.0LGALS3, PDGFRB
14Fc-epsilon receptor signaling pathwayGO:03809510.0PDGFRB, RAF1, KRAS, FGFR1
15epidermal growth factor receptor signaling pathwayGO:00717310.0PDGFRB, RAF1, KRAS, FGFR1
16neuron migrationGO:00176410.0FGFR1, NTRK2, DCX
17small GTPase mediated signal transductionGO:0072649.9BRAF, SRGAP3, RAF1, KRAS
18positive regulation of chemotaxisGO:0509219.9THBS1, PDGFRB
19fibroblast growth factor receptor signaling pathwayGO:0085439.9BRAF, PDGFRB, RAF1, KRAS, FGFR1
20regulation of neuronal synaptic plasticityGO:0481689.8SYP, S100B
21axon guidanceGO:0074119.8DCX, RAF1, KRAS, FGFR1
22neurotrophin TRK receptor signaling pathwayGO:0480119.7FGFR1, KRAS, RAF1, PDGFRB, NTRK2, BRAF
23negative regulation of apoptotic processGO:0430669.5THBS1, SOX10, BRAF, PDGFRB, RAF1
24central nervous system developmentGO:0074179.5DCX, NES, S100B
25extracellular matrix organizationGO:0301989.5THBS1, GFAP, TNC, LGALS3
26positive regulation of cell proliferationGO:0082849.4TNC, NTRK2, PDGFRB, S100B, KRAS, FGFR1
27innate immune responseGO:0450879.3LGALS3, PDGFRB, RAF1, S100B, KRAS, FGFR1
28cell migrationGO:0164779.3FGFR1, PDGFRB, THBS1

Molecular functions related to Pilocytic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitogen-activated protein kinase kinase bindingGO:03143410.1RAF1, BRAF
2small GTPase bindingGO:0312679.8RAF1, BRAF
3identical protein bindingGO:0428028.7FGFR1, THBS1, SOX10, BRAF, SYP, RAF1
4protein bindingGO:0055157.3THBS1, APOD, TIMP3, SOX10, BRAF, SRGAP3

Products for genes affiliated with Pilocytic Astrocytoma

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Sources for Pilocytic Astrocytoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet