MCID: PLC011
MIFTS: 45

Pilocytic Astrocytoma malady

Neuronal diseases, Cancer diseases categories

Summaries for Pilocytic Astrocytoma

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Pilocytic astrocytoma is an often benign, slow-growing tumor of the brain or spinal cord. the tumor may be in the form of a cyst and usually does not spread to nearby tissues. symptoms vary depending upon the size and location of the tumor. most symptoms result from increased pressure on the brain and include headaches, nausea, vomiting, balance problems, and vision abnormalities. the underlying cause of a pilocytic astrocytoma is unknown. it most commonly occurs in children and young adults, and in people with neurofibromatosis type 1 (nf1), li-fraumeni syndrome, and tuberous sclerosis. this type of tumor can often be cured with surgery. last updated: 8/9/2013

MalaCards: Pilocytic Astrocytoma, also known as juvenile pilocytic astrocytoma, is related to astrocytoma and neurofibromatosis. An important gene associated with Pilocytic Astrocytoma is KIAA1549 (KIAA1549), and among its related pathways are Ras signaling in the CD4+ TCR pathway and FGFR2c ligand binding and activation. The compounds estrogen and glutamate have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and cerebellum, and related mouse phenotypes are vision/eye and integument.

Wikipedia:63 Pilocytic astrocytoma or juvenile pilocytic astrocytoma or cystic cerebellar astrocytoma (and its... more...

Aliases & Classifications for Pilocytic Astrocytoma

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42NIH Rare Diseases, 60UMLS, 10DISEASES, 44Novoseek, 48Orphanet, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
pilocytic astrocytoma:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

pilocytic astrocytoma 42 10 44 48 60
juvenile pilocytic astrocytoma 42 60


External Ids:

SNOMED-CT via Orphanet57 128854008

Related Diseases for Pilocytic Astrocytoma

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17GeneCards, 18GeneDecks
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Diseases in the Pilocytic Astrocytoma family:

Juvenile Pilocytic Astrocytoma

Diseases related to Pilocytic Astrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma32.0LGALS3, TNC, SYP, GFAP, FGFR1, CDK4
2neurofibromatosis30.9KRAS, S100B, NF1, RAF1
3medulloblastoma30.7CDK4, NES, SYP, NTRK2, GFAP, S100B
4oligodendroglioma30.6BRAF, GFAP
5meningioma30.5TNC, GFAP, NF1, SYP, S100B
6dysembryoplastic neuroepithelial tumor30.4KIAA1549, SYP
7glioblastoma multiforme30.4GFAP, CDK4, NES, TNC
8ganglioglioma30.4GFAP, SYP, DCX, APOD, S100B, NTRK2
9leukemia30.4NF1, IDH1, FGFR1, NES, CDK4, RAF1
10gliosarcoma30.2GFAP, CDK4
11hydrocephalus30.2NF1, NES
12myxopapillary ependymoma30.2S100B, GFAP
13hemangioblastoma30.2GFAP, SYP, NES, S100B
14choroid plexus carcinoma30.2GFAP, S100B
15gemistocytic astrocytoma30.2GFAP, S100B
16noonan syndrome30.1KRAS, RAF1, NF1, BRAF
17acute leukemia30.1NF1, KRAS, FGFR1
18adenocarcinoma30.1TNC, BRAF, NES, TIMP3, CDK4, SYP
19malignant glioma30.1TIMP3, BRAF, IDH1, S100B, SOX10, TNC
20juvenile pilocytic astrocytoma11.0
21juvenile astrocytoma10.9
22cerebellar astrocytoma10.8
23childhood pilocytic astrocytoma10.7
24pilocytic astrocytoma of cerebellum10.6
25diencephalic astrocytomas10.5
26spinal cord astrocytoma10.5
27pilomyxoid astrocytoma10.4
28cerebritis10.4
29optic nerve astrocytoma10.4
30autism spectrum disorder10.3
31cervicitis10.3
32craniopharyngioma10.3
33silver-russell syndrome10.1
34brain oligodendroglioma10.1
35brain compression10.1
36choroiditis10.1
37sensorineural hearing loss10.1
38trigonitis10.1
39gonadoblastoma10.1
40arteriovenous malformation10.1
41temporal lobe epilepsy10.1
42frasier syndrome10.1
43intracranial aneurysm10.1
44dermoid cyst of ovary10.1
45fibrillary astrocytoma10.1
46siderosis10.1
47benign meningioma10.1
48adult syndrome10.1
49albright's hereditary osteodystrophy10.1
50obstructive hydrocephalus10.1

Graphical network of the top 20 diseases related to Pilocytic Astrocytoma:



Diseases related to pilocytic astrocytoma

Clinical Features for Pilocytic Astrocytoma

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Drugs & Therapeutics for Pilocytic Astrocytoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pilocytic Astrocytoma

Drug clinical trials:

Search ClinicalTrials for Pilocytic Astrocytoma

Search NIH Clinical Center for Pilocytic Astrocytoma

Search CenterWatch for Pilocytic Astrocytoma

Genetic Tests for Pilocytic Astrocytoma

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Anatomical Context for Pilocytic Astrocytoma

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32MalaCards
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MalaCards organs/tissues related to Pilocytic Astrocytoma:

32
Brain, Spinal cord, Cerebellum

Animal Models for Pilocytic Astrocytoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pilocytic Astrocytoma:

36 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539110.7TIMP3, NTRK2, RAF1, GFAP
2MP:001077110.7TIMP3, S100B, SOX10, CDK4, FGFR1, RAF1
3MP:000118610.6NF1
4MP:000536910.6BRAF, NF1, CDK4, FGFR1, RAF1, GFAP
5MP:000537910.6SOX10, NTRK2, NF1, CDK4, FGFR1, KRAS
6MP:000287310.6BRAF, S100B, SOX10, TNC, SYP, NTRK2
7MP:000537610.6TIMP3, IDH1, TNC, APOD, NTRK2, NF1
8MP:000536710.6LGALS3, FGFR1, TIMP3
9MP:000363110.6SOX10, TNC, APOD, DCX, SYP, NTRK2
10MP:000538010.5SOX10, NES
11MP:000538410.5TIMP3, BRAF, SOX10, NES, NTRK2, NF1
12MP:000538510.5TIMP3, BRAF, NF1, CDK4, FGFR1, RAF1
13MP:000538710.5TIMP3, BRAF, IDH1, NF1, CDK4, FGFR1
14MP:001076810.5DCX, NES, APOD, SOX10, BRAF, TIMP3
15MP:000537810.5DCX, NES, SOX10, BRAF, TIMP3, NTRK2
16MP:000538610.5SRGAP3, TIMP3, BRAF, S100B, SOX10, TNC
17MP:000538810.4TIMP3, NTRK2, NF1, RAF1, KRAS, LGALS3
18MP:000538110.3BRAF, SOX10, CDK4, FGFR1, GFAP, KRAS
19MP:000539710.3BRAF, IDH1, NF1, CDK4, RAF1, KRAS
20MP:000537710.3TNC, APOD, NTRK2, NF1, FGFR1
21MP:000537010.1TIMP3, BRAF, NF1, CDK4, RAF1, KRAS

Publications for Pilocytic Astrocytoma

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Genetic Variations for Pilocytic Astrocytoma

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Expression for genes affiliated with Pilocytic Astrocytoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pilocytic Astrocytoma

Search GEO for disease gene expression data for Pilocytic Astrocytoma.

Pathways for genes affiliated with Pilocytic Astrocytoma

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Sources:
37NCBI BioSystems Database, 53Reactome, 59Tocris Bioscience, 4Cell Signaling Technology, 29KEGG, 12EMD Millipore, 52R&D Systems, 49PharmGKB, 51QIAGEN, 55SinoBiological
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Pathways related to Pilocytic Astrocytoma according to GeneCards/GeneDecks:

(show all 46)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5RAF1, BRAF
2
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10.5KRAS, RAF1
3
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10.4KRAS, RAF1, BRAF
410.4BRAF, RAF1, KRAS
510.4BRAF, RAF1, KRAS
610.4BRAF, RAF1, KRAS
710.4BRAF, RAF1, KRAS
8
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10.4KRAS, RAF1, BRAF
9
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10.4BRAF, RAF1, KRAS
10
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10.4SRGAP3, KRAS, RAF1
11
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10.4BRAF, FGFR1, RAF1
1210.4KRAS, RAF1, FGFR1
1310.4LGALS3, S100B
14
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10.4BRAF, NF1, RAF1
15
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10.4BRAF, FGFR1, RAF1, KRAS
1610.4BRAF, CDK4, RAF1
17
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10.4BRAF, NTRK2, RAF1, KRAS
1810.4KRAS, RAF1, NTRK2, BRAF
1910.4TIMP3, TNC, FGFR1
20
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10.4BRAF, NTRK2, FGFR1, RAF1
21
G-protein signaling Ras family GTPases in kinase cascades (scheme)
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10.4KRAS, RAF1, BRAF, TIMP3
22
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10.4KRAS, RAF1, NF1, BRAF
23
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10.4KRAS, RAF1, FGFR1, TIMP3
24
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10.4BRAF, CDK4, RAF1, KRAS
25
Hide members
10.4BRAF, CDK4, RAF1, KRAS
26
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10.4FGFR1, NTRK2, BRAF, TIMP3
2710.4TIMP3, TNC, RAF1, KRAS
2810.4GFAP, FGFR1, SOX10
29
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10.4BRAF, NTRK2, FGFR1, RAF1, KRAS
30
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10.4TIMP3, DCX, NTRK2
3110.4KRAS, RAF1, FGFR1, CDK4
3210.4NTRK2, CDK4, FGFR1, KRAS
3310.4TIMP3, BRAF, FGFR1, RAF1, KRAS
3410.4BRAF, NF1, CDK4, KRAS
3510.4BRAF, NF1, CDK4, RAF1
36
Hide members
10.4TIMP3, BRAF, NTRK2, FGFR1, RAF1
3710.4BRAF, CDK4, FGFR1, RAF1, KRAS
3810.4KRAS, RAF1, FGFR1, CDK4, TNC
39
Hide members
10.4BRAF, NTRK2, NF1, FGFR1, RAF1, KRAS
40
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10.4TIMP3, BRAF, TNC, NTRK2, FGFR1, RAF1
41
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10.4S100B, FGFR1, RAF1, GFAP, KRAS
42
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10.4BRAF, NF1, CDK4, FGFR1, RAF1, KRAS
43
Hide members
10.4TIMP3, BRAF, NTRK2, CDK4, FGFR1, RAF1
4410.3S100B, TNC, DCX, SYP, NTRK2, GFAP
45
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10.3BRAF, S100B, TNC, NTRK2, FGFR1, RAF1
46
Hide members
10.3GFAP, TIMP3, BRAF, SOX10, TNC, NTRK2

Compounds for genes affiliated with Pilocytic Astrocytoma

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Pilocytic Astrocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 92)
idCompoundScoreTop Affiliating Genes
1estrogen4410.9NF1, GFAP
2glutamate4410.8IDH1, GFAP, NTRK2
3matrigel4410.8BRAF, NES, NTRK2
4ly2940024410.8TNC, CDK4, RAF1, KRAS, NTRK2, BRAF
5serine4410.8GFAP, NF1, KRAS, DCX, S100B, SYP
6glucose4410.8FGFR1, TIMP3, BRAF, GFAP
7dopamine44 28 11 2413.8GFAP, NF1, NTRK2, FGFR1, RAF1, NES
8paclitaxel44 49 1112.7RAF1, S100B, GFAP, KRAS, CDK4, BRAF
9fatty acid4410.7BRAF, LGALS3, KRAS, NF1, IDH1
10wortmannin4410.7LGALS3, TIMP3, KRAS, RAF1, TNC, BRAF
11agar4410.7GFAP, RAF1, BRAF, FGFR1, CDK4, LGALS3
12forskolin44 49 1112.7RAF1, NTRK2, SYP, GFAP, FGFR1, NF1
13phosphatidylinositol4410.7FGFR1, RAF1, KRAS, NF1, NTRK2, TNC
14oligonucleotide4410.7BRAF, TIMP3, LGALS3, TNC, APOD, CDK4
15pd 98,0594410.7FGFR1, CDK4, BRAF, GFAP, TIMP3, RAF1
16cisplatin44 49 59 1113.7NTRK2, BRAF, LGALS3, SYP, CDK4, RAF1
17bromodeoxyuridine4410.7S100B, NES, DCX, CDK4, FGFR1, GFAP
18s 1004410.7GFAP, S100B, SYP
19testosterone44 59 11 2413.7APOD, SYP, NTRK2, CDK4, FGFR1, TIMP3
20gaba4410.7GFAP, NTRK2, SYP, NES, TNC, S100B
21cyclic amp44 2411.7NF1, NTRK2, SYP, S100B, BRAF, GFAP
22kainate44 2811.7SYP, NES, DCX, NTRK2, GFAP
23imatinib44 49 1112.7BRAF, S100B, FGFR1, KRAS, RAF1
24glutamine4410.7TIMP3, IDH1, S100B, SYP, RAF1, GFAP
25streptozotocin4410.7SYP, GFAP, NES, RAF1
26cysteine4410.7TIMP3, TNC, S100B, SYP, NF1, CDK4
27paraffin4410.7LGALS3, KRAS, GFAP, CDK4, NF1, SYP
28choline44 11 2412.7GFAP, RAF1, SYP, S100B, NES
29threonine4410.7BRAF, S100B, CDK4, LGALS3, GFAP, RAF1
30formaldehyde44 2411.6S100B, SYP, GFAP, LGALS3, TNC
31progesterone44 59 28 11 2414.6S100B, TNC, APOD, SYP, NF1, CDK4
32lipid4410.6APOD, TNC, BRAF, TIMP3, S100B, NES
33alanine4410.6NTRK2, CDK4, RAF1, BRAF, GFAP, S100B
34vegf4410.6TNC, NES, DCX, SYP, NTRK2, CDK4
35valine4410.6CDK4, RAF1, S100B, BRAF, KRAS
36h2o24410.6TNC, LGALS3, FGFR1, RAF1, KRAS, SYP
37tyrosine4410.6FGFR1, BRAF, TIMP3, TNC, RAF1, LGALS3
38phosphoinositide4410.6RAF1, LGALS3, KRAS, BRAF, TNC, NTRK2
39retinoic acid44 2411.6TIMP3, BRAF, S100B, CDK4, LGALS3, KRAS
40calcium44 49 11 2413.6IDH1, FGFR1, GFAP, LGALS3, NF1, CDK4
41hematoxylin4410.6S100B, GFAP, LGALS3, SYP
42oxygen44 2411.5KRAS, TIMP3, S100B, LGALS3, GFAP, CDK4
43steroid4410.5CDK4, NF1, TIMP3, SYP
44genistein44 28 59 2 11 2415.5GFAP, RAF1, FGFR1, CDK4, SYP, TIMP3
45gtp44 2811.5NF1, KRAS, S100B, BRAF, RAF1, SYP
46reticulin4410.5SYP, S100B, GFAP
47chondroitin sulfate44 2411.4TIMP3, TNC, FGFR1, GFAP
48dexamethasone44 49 28 1113.4S100B, CDK4, RAF1, GFAP, TIMP3
49dbc-amp4410.3S100B, GFAP, SYP, TIMP3
50arginine4410.0LGALS3, GFAP, CDK4, NF1, S100B, BRAF

GO Terms for genes affiliated with Pilocytic Astrocytoma

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16Gene Ontology
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Cellular components related to Pilocytic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1presynaptic active zoneGO:04878610.4NTRK2, SYP
2cytosolGO:00582910.0SRGAP3, BRAF, IDH1, DCX, NTRK2, CDK4

Biological processes related to Pilocytic Astrocytoma according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1MAPK cascadeGO:00016510.7KRAS, RAF1, FGFR1, NF1
2regulation of long-term neuronal synaptic plasticityGO:04816910.7KRAS, NF1, SYP
3long-term synaptic potentiationGO:06029110.7S100B, NTRK2, GFAP
4neurotrophin TRK receptor signaling pathwayGO:04801110.7KRAS, RAF1, FGFR1, NTRK2, BRAF
5positive regulation of gene expressionGO:01062810.7BRAF, TNC, NTRK2, KRAS
6positive regulation of cell proliferationGO:00828410.7S100B, TNC, NTRK2, CDK4, FGFR1, KRAS
7fibroblast growth factor receptor signaling pathwayGO:00854310.6KRAS, RAF1, FGFR1, BRAF
8activation of MAPKK activityGO:00018610.6KRAS, RAF1, BRAF
9peripheral nervous system axon regenerationGO:01401210.6APOD, TNC
10brain developmentGO:00742010.6APOD, NES, DCX, NF1
11regulation of synaptic transmission, GABAergicGO:03222810.6NF1, KRAS
12negative regulation of apoptotic processGO:04306610.5RAF1, FGFR1, NES, SOX10, BRAF
13Ras protein signal transductionGO:00726510.4NF1, RAF1, KRAS
14neuron migrationGO:00176410.4FGFR1, NTRK2, DCX
15extracellular matrix organizationGO:03019810.3LGALS3, GFAP, NF1, TNC
16innate immune responseGO:04508710.1S100B, FGFR1, RAF1, KRAS, LGALS3

Molecular functions related to Pilocytic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280210.4RAF1, FGFR1, SYP, SOX10, S100B, BRAF

Products for genes affiliated with Pilocytic Astrocytoma

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  • Antibodies
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Sources for Pilocytic Astrocytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet