MCID: PLC011
MIFTS: 49

Pilocytic Astrocytoma malady

Rare diseases, Neuronal diseases, Cancer diseases categories

Aliases & Classifications for Pilocytic Astrocytoma

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Sources:
41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 61UMLS via Orphanet
See all sources

Pilocytic Astrocytoma, Aliases & Descriptions:

Name: Pilocytic Astrocytoma 41 11 43 47 60
 
Juvenile Pilocytic Astrocytoma 41 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

47
pilocytic astrocytoma:
Inheritance: Not applicable; Age of onset: All ages


External Ids:

Orphanet47 251612
UMLS via Orphanet61 C0334583

Summaries for Pilocytic Astrocytoma

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NIH Rare Diseases:41 Pilocytic astrocytoma is an often benign, slow-growing tumor of the brain or spinal cord. the tumor may be in the form of a cyst and usually does not spread to nearby tissues. symptoms vary depending upon the size and location of the tumor. most symptoms result from increased pressure on the brain and include headaches, nausea, vomiting, balance problems, and vision abnormalities. the underlying cause of a pilocytic astrocytoma is unknown. it most commonly occurs in children and young adults, and in people with neurofibromatosis type 1 (nf1), li-fraumeni syndrome, and tuberous sclerosis. this type of tumor can often be cured with surgery. last updated: 8/9/2013

MalaCards based summary: Pilocytic Astrocytoma, also known as juvenile pilocytic astrocytoma, is related to dysembryoplastic neuroepithelial tumor and oligodendroglioma. An important gene associated with Pilocytic Astrocytoma is KIAA1549 (KIAA1549), and among its related pathways are Renal cell carcinoma and Signalling to ERKs. The compounds regorafenib and sorafenib have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and cerebellum, and related mouse phenotypes are pigmentation and embryogenesis.

Wikipedia:63 Pilocytic astrocytoma or juvenile pilocytic astrocytoma or cystic cerebellar astrocytoma (and its... more...

Related Diseases for Pilocytic Astrocytoma

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Diseases in the Pilocytic Astrocytoma family:

Juvenile Pilocytic Astrocytoma

Diseases related to Pilocytic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1dysembryoplastic neuroepithelial tumor31.4KIAA1549, SYP
2oligodendroglioma31.4GFAP, BRAF
3neurofibromatosis31.2KRAS, S100B, RAF1
4gliosarcoma31.0PDGFRB, GFAP
5myxopapillary ependymoma30.9S100B, GFAP
6choroid plexus carcinoma30.9S100B, GFAP
7glioblastoma multiforme30.8THBS1, GFAP, TNC, NES, PDGFRB
8hemangioblastoma30.7GFAP, NES, SYP, S100B
9medulloblastoma30.6GFAP, TIMP3, NES, NTRK2, SYP, S100B
10ependymoma30.6GFAP, TIMP3, DCX, NES, SYP, S100B
11astrocytoma30.6IDH1, THBS1, GFAP, TNC, FGFR1, S100B
12anaplastic oligodendroglioma30.4GFAP, LGALS3
13ganglioglioma30.3S100B, SYP, NTRK2, DCX, APOD, GFAP
14leukemia30.0IDH1, NES, PDGFRB, RAF1, KRAS, FGFR1
15glioblastoma29.3FGFR1, S100B, RAF1, PDGFRB, NTRK2, LGALS3
16adenocarcinoma28.5THBS1, TNC, TIMP3, FGFR1, KRAS, RAF1
17malignant glioma28.0FGFR1, S100B, RAF1, PDGFRB, SYP, NTRK2
18juvenile pilocytic astrocytoma11.0
19giant cell glioblastoma10.6GFAP
20glomus tumor10.6SYP
21gliomatosis cerebri10.6GFAP
22pilocytic astrocytoma of cerebellum10.6
23childhood pilocytic astrocytoma10.6
24medulloepithelioma10.5SYP
25neurofibromatosis, type 110.5
26melanotic neuroectodermal tumor10.5SYP
27cerebritis10.5
28pilomyxoid astrocytoma10.5
29binswanger's disease10.5SYP, GFAP
30central neurocytoma10.4GFAP, SYP
31breast cancer10.4APOD, SYP
32endotheliitis10.4
33anaplastic ependymoma10.4GFAP, S100B
34gemistocytic astrocytoma10.4GFAP, S100B
35subependymal giant cell astrocytoma10.4SYP, S100B
36olfactory neuroblastoma10.4SYP, S100B
37choroid plexus papilloma10.4GFAP
38clear cell sarcoma10.4BRAF, S100B
39pleomorphic adenoma10.4GFAP, TNC, S100B
40vitreoretinopathy, neovascular inflammatory10.4THBS1, GFAP, TNC
41papillary ependymoma10.4GFAP, SYP, S100B
42syringoma10.4GFAP, S100B
43pineocytoma10.4GFAP, SYP, S100B
44cardiofaciocutaneous syndrome10.3BRAF, KRAS
45amelanotic melanoma10.3THBS1, S100B
46vascular cancer10.3THBS1, PDGFRB
47paraganglioma10.3GFAP, SYP, S100B
48autism spectrum disorder10.3
49cervicitis10.3
50craniopharyngioma10.3

Graphical network of the top 20 diseases related to Pilocytic Astrocytoma:



Diseases related to pilocytic astrocytoma

Symptoms for Pilocytic Astrocytoma

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Drugs & Therapeutics for Pilocytic Astrocytoma

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Drug clinical trials:

Search ClinicalTrials for Pilocytic Astrocytoma

Search NIH Clinical Center for Pilocytic Astrocytoma

Genetic Tests for Pilocytic Astrocytoma

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Anatomical Context for Pilocytic Astrocytoma

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MalaCards organs/tissues related to Pilocytic Astrocytoma:

31
Brain, Spinal cord, Cerebellum, Pineal, Endothelial, Ovary, Temporal lobe, Medulla oblongata, Tongue, Bone, Retina, Breast, Hypothalamus, Pituitary

Animal Models for Pilocytic Astrocytoma or affiliated genes

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MGI Mouse Phenotypes related to Pilocytic Astrocytoma:

35 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.6KRAS, BRAF, SOX10, TIMP3
2MP:00053809.0SOX10, BRAF, NES, PDGFRB, RAF1, KRAS
3MP:00053678.9THBS1, TIMP3, BRAF, LGALS3, PDGFRB, KRAS
4MP:00053908.8THBS1, BRAF, LGALS3, NTRK2, PDGFRB, RAF1
5MP:00053888.8THBS1, TIMP3, SOX10, BRAF, LGALS3, NTRK2
6MP:00053698.7THBS1, GFAP, TIMP3, BRAF, PDGFRB, RAF1
7MP:00053798.7THBS1, TIMP3, SOX10, BRAF, NTRK2, PDGFRB
8MP:00053818.6THBS1, GFAP, SOX10, BRAF, LGALS3, PDGFRB
9MP:00053918.6THBS1, GFAP, TIMP3, BRAF, NTRK2, PDGFRB
10MP:00053898.3THBS1, DCX, BRAF, LGALS3, NTRK2, PDGFRB
11MP:00028738.3GFAP, TNC, SOX10, BRAF, NTRK2, SYP
12MP:00053978.3THBS1, IDH1, TIMP3, BRAF, LGALS3, PDGFRB
13MP:00053858.2THBS1, GFAP, APOD, TIMP3, BRAF, LGALS3
14MP:00107718.1BRAF, SOX10, TIMP3, THBS1, LGALS3, PDGFRB
15MP:00053878.1THBS1, IDH1, GFAP, TIMP3, BRAF, LGALS3
16MP:00053787.9SOX10, DCX, TIMP3, GFAP, THBS1, BRAF
17MP:00053847.8BRAF, SOX10, TIMP3, GFAP, THBS1, NES
18MP:00053867.7SOX10, DCX, TIMP3, APOD, TNC, GFAP
19MP:00036317.4FGFR1, GFAP, TNC, APOD, DCX, SOX10
20MP:00053767.4TIMP3, APOD, TNC, GFAP, IDH1, THBS1
21MP:00107687.2SOX10, DCX, TIMP3, APOD, GFAP, THBS1

Publications for Pilocytic Astrocytoma

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Articles related to Pilocytic Astrocytoma:

(show top 50)    (show all 320)
idTitleAuthorsYear
1
Long survival in a child with a mutated K27M-H3.3 pilocytic astrocytoma. (25909089)
2015
2
Anaplastic pilocytic astrocytoma. (24954244)
2014
3
A pilocytic astrocytoma mimicking a clinoidal meningioma. (24744944)
2014
4
A case of central precocious puberty due to concomitant hypothalamic hamartoma and juvenile pilocytic astrocytoma. (25241615)
2014
5
A 10year retrospective study of surgical outcomes of adult intracranial pilocytic astrocytoma. (25065843)
2014
6
Transformation of adult cerebellar pilocytic astrocytoma to glioblastoma. (23884731)
2013
7
Differential expression of the tumor suppressor A-kinase anchor protein 12 in human diffuse and pilocytic astrocytomas is regulated by promoter methylation. (24042196)
2013
8
Cerebellar metastasis from serous adenocarcinoma of the ovary mimicking pilocytic astrocytoma. (23293670)
2012
9
Juvenile pilocytic astrocytoma in association with arteriovenous malformation. (22681727)
2012
10
MAPK pathway activation in pilocytic astrocytoma. (22159586)
2012
11
Pilocytic astrocytoma with extensive psammomatous calcification in the lateral ventricle: a case report. (22167267)
2012
12
Vascular endothelial growth factor receptor 2 (VEGFR-2) signalling activity in paediatric pilocytic astrocytoma is restricted to tumour endothelial cells. (21208252)
2011
13
Primary cerebellar pilocytic astrocytoma with anaplastic features in a patient with neurofibromatosis type 1 - case report - . (21515958)
2011
14
An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice. (21403401)
2011
15
Proteomics studies of childhood pilocytic astrocytoma. (21466243)
2011
16
Immune cell infiltrate differences in pilocytic astrocytoma and glioblastoma: evidence of distinct immunological microenvironments that reflect tumor biology. (21663411)
2011
17
Magnetic resonance imaging features of pilocytic astrocytoma of the brain mimicking high-grade gliomas. (20657231)
2010
18
Management of intramedullary cystic pilocytic astrocytoma with rhenium-186 intracavitary irradiation: case report. (20404673)
2010
19
Acute v pattern esotropia without abduction deficit, secondary to a posterior fossa pilocytic astrocytoma. (19645405)
2009
20
Somatic mitochondrial mutations in pilocytic astrocytoma. (19480934)
2009
21
Histopathologic predictors of pilocytic astrocytoma event-free survival. (19271226)
2009
22
Real-time quantitative polymerase chain reaction (qPCR) analysis with fluorescence resonance energy transfer (FRET) probes reveals differential expression of the four ERBB4 juxtamembrane region variants between medulloblastoma and pilocytic astrocytoma. (19017278)
2009
23
Long-term functional outcome of surgical treatment of juvenile pilocytic astrocytoma of the cerebellum in children. (19418058)
2009
24
Diurnally fluctuating frontal dysequilibrium secondary to a pineal pilocytic astrocytoma: is this symptom associated with a check-valve mechanism in a pineal region tumor? (18972117)
2009
25
Cerebellar pilocytic astrocytoma presenting with intratumor bleeding, subarachnoid hemorrhage, and subdural hematoma. (18629510)
2009
26
Calcified pilocytic astrocytoma of the medulla mimicking a brainstem "stone". (19253601)
2008
27
Pilocytic astrocytoma with spontaneous intracranial hemorrhages in an elderly adult. (16621238)
2007
28
Occurrence of a spinal anaplastic pilocytic astrocytoma and a supratentorial PNET in an adolescent. (18090931)
2007
29
Paired overexpression of ErbB3 and Sox10 in pilocytic astrocytoma. (16896310)
2006
30
Large cystic cavernous angioma of the cerebellum mimicking pilocytic astrocytoma. (16821089)
2006
31
Disseminated pilocytic astrocytoma involving brain stem and diencephalon: a history of atypical eating disorder and diagnostic delay. (16598421)
2006
32
Radical resection for intrinsic midbrain pilocytic astrocytoma: report of two cases. (15309583)
2005
33
No aberrant methylation of neurofibromatosis 1 gene (NF1) promoter in pilocytic astrocytoma in childhood. (15770836)
2005
34
Exophytic pilocytic astrocytoma of the brain stem in an adult with encasement of the caudal cranial nerve complex (IX-XII): presurgical anatomical neuroimaging using MRI. (14740164)
2004
35
Juvenile pilocytic astrocytoma 'pilomyxoid variant' with spinal metastases. (15261239)
2004
36
Juvenile pilocytic astrocytoma. (12880155)
2003
37
Mutational and expression analysis of the NF1 gene argues against a role as tumor suppressor in sporadic pilocytic astrocytomas. (12387455)
2002
38
Pilocytic astrocytomas do not show most of the genetic changes commonly seen in diffuse astrocytomas. (11119125)
2000
39
Involution of diencephalic pilocytic astrocytoma after partial resection. Report of two cases in adults. (10969949)
2000
40
Low grade pilocytic astrocytoma presenting as a spontaneous intracerebral haemorrhage in a child. (11013653)
1998
41
Hypothalamic pilocytic astrocytoma presenting with intratumoral and subarachnoid hemorrhage. (9414929)
1997
42
Transient amnestic syndrome after spontaneous haemorrhage into a hypothalamic pilocytic astrocytoma. (7608691)
1995
43
The significance of atypia and histologic malignancy in pilocytic astrocytoma of the cerebellum: a clinicopathologic and flow cytometric study. (7930411)
1994
44
Fatal hemorrhage in a cerebral pilocytic astrocytoma-adult type. (1882644)
1991
45
Metastatic juvenile pilocytic astrocytoma. Case report. (1941128)
1991
46
Treatment results of juvenile pilocytic astrocytoma. (3392563)
1988
47
Anaplastic evolution of childhood optico-hypothalamic pilocytic astrocytoma: report of an autopsy case. (3208464)
1988
48
Cerebral pilocytic astrocytoma. (4016701)
1985
49
Pilocytic astrocytoma of the optic nerve with hemorrhage and extreme cystic degeneration. (7304696)
1981
50
Malignant evolution of childhood chiasmal pilocytic astrocytoma. (944389)
1976

Variations for Pilocytic Astrocytoma

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Expression for genes affiliated with Pilocytic Astrocytoma

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Search GEO for disease gene expression data for Pilocytic Astrocytoma.

Pathways for genes affiliated with Pilocytic Astrocytoma

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Pathways related to Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 59)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0KRAS, RAF1, BRAF
2
Show member pathways
10.0BRAF, RAF1, KRAS
3
Show member pathways
10.0BRAF, RAF1, KRAS
410.0BRAF, RAF1, KRAS
510.0BRAF, RAF1, KRAS
610.0BRAF, RAF1, KRAS
7
Show member pathways
10.0FGFR1, KRAS, RAF1
89.8RAF1, PDGFRB, BRAF
9
Show member pathways
9.8FGFR1, KRAS, RAF1, BRAF
109.8FGFR1, PDGFRB, NTRK2
119.7FGFR1, TNC, THBS1
12
Show member pathways
MAPK Cascade36
Immune response Oncostatin M signaling via MAPK in human cells58
Oncostatin M Signaling Pathway36
9.7KRAS, RAF1, BRAF, TIMP3
13
Show member pathways
9.7FGFR1, KRAS, RAF1, TIMP3
14
Show member pathways
Transcription Receptor mediated HIF regulation58
Development CNTF receptor signaling58
Class IB PI3K non-lipid kinase events36
ErbB2/ErbB3 signaling events36
Development Growth hormone signaling via PI3K AKT and MAPK cascades58
Translation Regulation activity of EIF258
Regulation of lipid metabolism Insulin signaling generic cascades58
Transcription PPAR Pathway58
Cell adhesion PLAU signaling58
Translation Regulation activity of EIF4F58
9.7KRAS, RAF1, PDGFRB, BRAF
15
Show member pathways
9.7KRAS, RAF1, PDGFRB, BRAF
16
Show member pathways
Development EDNRB signaling58
Development ACM2 and ACM4 activation of ERK58
Cell adhesion Integrin inside out signaling58
Development G Proteins mediated regulation MARK ERK signaling58
Signal transduction IP3 signaling58
Development Angiotensin signaling via PYK258
Development EPO induced MAPK pathway58
9.7KRAS, RAF1, PDGFRB, BRAF
17
Show member pathways
9.6FGFR1, KRAS, PDGFRB, NTRK2
189.6NTRK2, PDGFRB, KRAS, FGFR1
19
Show member pathways
9.6NTRK2, PDGFRB, RAF1, FGFR1
209.5THBS1, RAF1, KRAS, FGFR1
21
Show member pathways
9.5DCX, SRGAP3, RAF1, KRAS, FGFR1
22
Show member pathways
9.5BRAF, PDGFRB, RAF1, KRAS, FGFR1
239.5FGFR1, KRAS, RAF1, PDGFRB, BRAF
24
Show member pathways
9.5FGFR1, KRAS, RAF1, PDGFRB, BRAF
259.5FGFR1, PDGFRB, TIMP3, TNC
26
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
9.5BRAF, NTRK2, PDGFRB, RAF1, KRAS
27
Show member pathways
9.5FGFR1, RAF1, PDGFRB, NTRK2, BRAF
28
Show member pathways
9.5FGFR1, RAF1, PDGFRB, NTRK2, BRAF
29
Show member pathways
9.3TIMP3, NTRK2, PDGFRB, RAF1, FGFR1
30
Show member pathways
9.3TIMP3, NTRK2, PDGFRB, RAF1, FGFR1
31
Show member pathways
9.3TIMP3, NTRK2, PDGFRB, RAF1, FGFR1
32
Show member pathways
MAPK signaling pathway36
9.3BRAF, NTRK2, PDGFRB, RAF1, KRAS, FGFR1
339.2FGFR1, KRAS, RAF1, PDGFRB, BRAF, IDH1
34
Show member pathways
Integrin-mediated cell adhesion36
Focal Adhesion36
9.2THBS1, TNC, BRAF, PDGFRB, RAF1
35
Show member pathways
9.2TIMP3, BRAF, NTRK2, PDGFRB, RAF1, FGFR1
36
Show member pathways
9.2TIMP3, BRAF, NTRK2, PDGFRB, RAF1, FGFR1
37
Show member pathways
9.2TIMP3, BRAF, NTRK2, PDGFRB, RAF1, FGFR1
38
Show member pathways
9.2TIMP3, BRAF, NTRK2, PDGFRB, RAF1, FGFR1
399.1THBS1, TIMP3, BRAF, RAF1, KRAS, FGFR1
40
Show member pathways
9.1THBS1, BRAF, PDGFRB, RAF1, KRAS, FGFR1
41
Show member pathways
Signaling Pathways in Glioblastoma36
9.1THBS1, BRAF, PDGFRB, RAF1, KRAS, FGFR1
429.0THBS1, TNC, PDGFRB, RAF1, KRAS, FGFR1
43
Show member pathways
9.0GFAP, PDGFRB, RAF1, S100B, KRAS, FGFR1
44
Show member pathways
9.0TNC, TIMP3, BRAF, NTRK2, PDGFRB, RAF1
458.9GFAP, TNC, DCX, NTRK2, SYP, S100B
468.9THBS1, TNC, TIMP3, PDGFRB, RAF1, KRAS
47
Show member pathways
8.9TIMP3, DCX, BRAF, NTRK2, PDGFRB, RAF1
48
Show member pathways
8.9THBS1, BRAF, NTRK2, PDGFRB, RAF1, KRAS
49
Show member pathways
8.5GFAP, TNC, TIMP3, SOX10, BRAF, NTRK2
50
Show member pathways
8.1THBS1, GFAP, BRAF, SRGAP3, NTRK2, PDGFRB

Compounds for genes affiliated with Pilocytic Astrocytoma

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Compounds related to Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 107)
idCompoundScoreTop Affiliating Genes
1regorafenib49 1210.9BRAF, PDGFRB, RAF1, KRAS, FGFR1
2sorafenib43 49 1211.8BRAF, PDGFRB, RAF1, FGFR1
3o6-methylguanine439.7KRAS, BRAF, TIMP3, THBS1
4s 100439.7S100B, SYP, GFAP
5streptozotocin439.7GFAP, NES, SYP, RAF1
6kainate43 2810.5GFAP, DCX, NES, NTRK2, SYP
7imatinib43 49 1211.5BRAF, PDGFRB, RAF1, S100B, KRAS, FGFR1
8chondroitin sulfate43 2410.5THBS1, GFAP, TNC, TIMP3, FGFR1
9choline43 24 1211.4GFAP, NES, SYP, RAF1, S100B
10gaba439.3GFAP, TNC, NES, NTRK2, SYP, S100B
11formaldehyde43 2410.2S100B, SYP, LGALS3, TNC, GFAP
12bromodeoxyuridine439.2GFAP, DCX, NES, PDGFRB, S100B, FGFR1
13forskolin43 49 1211.2GFAP, BRAF, NTRK2, SYP, RAF1, S100B
14pd 98,059439.2THBS1, GFAP, TIMP3, BRAF, NTRK2, RAF1
15dopamine43 28 24 1212.1GFAP, NES, NTRK2, SYP, RAF1, S100B
16agar439.0THBS1, GFAP, BRAF, LGALS3, PDGFRB, RAF1
17cisplatin43 49 59 1212.0GFAP, BRAF, LGALS3, NTRK2, SYP, PDGFRB
18hematoxylin438.9GFAP, LGALS3, SYP, S100B
19gtp43 289.9THBS1, BRAF, SYP, RAF1, S100B, KRAS
20phosphoinositide438.9THBS1, TNC, BRAF, LGALS3, NTRK2, PDGFRB
21genistein43 28 59 2 24 1213.9THBS1, GFAP, TIMP3, SYP, PDGFRB, RAF1
22methionine438.9THBS1, GFAP, TIMP3, PDGFRB, S100B, FGFR1
23fatty acid438.9IDH1, APOD, BRAF, LGALS3, S100B, KRAS
24glutamine438.8IDH1, GFAP, TIMP3, LGALS3, SYP, RAF1
25ly294002438.8THBS1, TNC, TIMP3, BRAF, NTRK2, PDGFRB
26heparin43 28 24 1211.8THBS1, TNC, TIMP3, LGALS3, RAF1, S100B
27paclitaxel43 49 1210.7THBS1, GFAP, SOX10, BRAF, PDGFRB, RAF1
28h2o2438.6THBS1, TNC, LGALS3, NTRK2, SYP, PDGFRB
29dexamethasone43 49 28 1211.5THBS1, GFAP, TNC, TIMP3, SYP, RAF1
30alanine438.5THBS1, GFAP, BRAF, LGALS3, NTRK2, PDGFRB
31matrigel438.5THBS1, GFAP, TNC, TIMP3, BRAF, NES
32nitric oxide43 24 1210.5NES, LGALS3, NTRK2, SYP, S100B, FGFR1
33wortmannin438.4THBS1, TNC, TIMP3, BRAF, LGALS3, PDGFRB
34threonine438.4THBS1, GFAP, BRAF, LGALS3, NTRK2, PDGFRB
35phosphatidylinositol438.4BRAF, TIMP3, TNC, THBS1, LGALS3, NTRK2
36oligonucleotide438.4TIMP3, APOD, TNC, THBS1, BRAF, LGALS3
37oxygen43 249.2THBS1, GFAP, TIMP3, NES, LGALS3, NTRK2
38glucose438.2THBS1, GFAP, APOD, TIMP3, BRAF, NES
39testosterone43 59 24 1211.2THBS1, GFAP, APOD, TIMP3, NTRK2, SYP
40glutamate438.1IDH1, GFAP, TNC, TIMP3, BRAF, NES
41cysteine438.0THBS1, GFAP, TNC, TIMP3, LGALS3, SYP
42paraffin437.7KRAS, S100B, PDGFRB, SYP, LGALS3, NES
43progesterone43 28 59 24 1211.6SYP, LGALS3, NES, BRAF, TIMP3, APOD
44serine437.6BRAF, DCX, TNC, GFAP, THBS1, LGALS3
45calcium43 49 24 1210.4THBS1, IDH1, GFAP, TNC, TIMP3, DCX
46tyrosine437.3NES, BRAF, TIMP3, TNC, GFAP, THBS1
47lipid437.3BRAF, TIMP3, APOD, TNC, GFAP, THBS1
48retinoic acid43 248.1TNC, GFAP, THBS1, APOD, RAF1, PDGFRB
49estrogen437.1FGFR1, KRAS, S100B, RAF1, PDGFRB, SYP
50vegf437.1FGFR1, TIMP3, TNC, GFAP, THBS1, DCX

GO Terms for genes affiliated with Pilocytic Astrocytoma

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Cellular components related to Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1presynaptic active zoneGO:004878610.0SYP, NTRK2
2extracellular matrixGO:00310129.1LGALS3, TIMP3, TNC, THBS1
3cytosolGO:00058298.5IDH1, GFAP, DCX, BRAF, SRGAP3, NTRK2

Biological processes related to Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1peripheral nervous system axon regenerationGO:001401210.3TNC, APOD
2activation of MAPKK activityGO:000018610.3KRAS, RAF1, BRAF
3positive regulation of phospholipase C activityGO:001086310.2FGFR1, PDGFRB
4MAPK cascadeGO:000016510.2RAF1, KRAS, FGFR1
5positive regulation of MAP kinase activityGO:004340610.2FGFR1, KRAS, PDGFRB
6positive regulation of phosphatidylinositol 3-kinase signalingGO:001406810.1FGFR1, PDGFRB, NTRK2
7positive regulation of gene expressionGO:001062810.1TNC, BRAF, NTRK2, KRAS
8negative regulation of neuron apoptotic processGO:004352410.1BRAF, NES, NTRK2, KRAS
9negative regulation of focal adhesion assemblyGO:005189510.1APOD, THBS1
10oligodendrocyte differentiationGO:004870910.1NTRK2, SOX10
11wound healingGO:004206010.1RAF1, PDGFRB, TNC
12long-term synaptic potentiationGO:006029110.0S100B, NTRK2, GFAP
13positive regulation of calcium ion importGO:009028010.0LGALS3, PDGFRB
14Fc-epsilon receptor signaling pathwayGO:003809510.0PDGFRB, RAF1, KRAS, FGFR1
15epidermal growth factor receptor signaling pathwayGO:000717310.0PDGFRB, RAF1, KRAS, FGFR1
16neuron migrationGO:000176410.0FGFR1, NTRK2, DCX
17small GTPase mediated signal transductionGO:00072649.9BRAF, SRGAP3, RAF1, KRAS
18positive regulation of chemotaxisGO:00509219.9THBS1, PDGFRB
19fibroblast growth factor receptor signaling pathwayGO:00085439.9BRAF, PDGFRB, RAF1, KRAS, FGFR1
20regulation of neuronal synaptic plasticityGO:00481689.8SYP, S100B
21axon guidanceGO:00074119.8DCX, RAF1, KRAS, FGFR1
22neurotrophin TRK receptor signaling pathwayGO:00480119.7FGFR1, KRAS, RAF1, PDGFRB, NTRK2, BRAF
23negative regulation of apoptotic processGO:00430669.5THBS1, SOX10, BRAF, PDGFRB, RAF1
24central nervous system developmentGO:00074179.5DCX, NES, S100B
25extracellular matrix organizationGO:00301989.5THBS1, GFAP, TNC, LGALS3
26positive regulation of cell proliferationGO:00082849.4TNC, NTRK2, PDGFRB, S100B, KRAS, FGFR1
27innate immune responseGO:00450879.3LGALS3, PDGFRB, RAF1, S100B, KRAS, FGFR1
28cell migrationGO:00164779.3FGFR1, PDGFRB, THBS1

Molecular functions related to Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mitogen-activated protein kinase kinase bindingGO:003143410.1RAF1, BRAF
2small GTPase bindingGO:00312679.8RAF1, BRAF
3identical protein bindingGO:00428028.7FGFR1, THBS1, SOX10, BRAF, SYP, RAF1
4protein bindingGO:00055157.3THBS1, APOD, TIMP3, SOX10, BRAF, SRGAP3

Products for genes affiliated with Pilocytic Astrocytoma

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3CDC
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