MCID: PLC011
MIFTS: 57

Pilocytic Astrocytoma malady

Rare diseases, Neuronal diseases, Cancer diseases categories
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Summaries for Pilocytic Astrocytoma

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NIH Rare Diseases:42 Pilocytic astrocytoma is an often benign, slow-growing tumor of the brain or spinal cord. the tumor may be in the form of a cyst and usually does not spread to nearby tissues. symptoms vary depending upon the size and location of the tumor. most symptoms result from increased pressure on the brain and include headaches, nausea, vomiting, balance problems, and vision abnormalities. the underlying cause of a pilocytic astrocytoma is unknown. it most commonly occurs in children and young adults, and in people with neurofibromatosis type 1 (nf1), li-fraumeni syndrome, and tuberous sclerosis. this type of tumor can often be cured with surgery. last updated: 8/9/2013

MalaCards based summary: Pilocytic Astrocytoma, also known as juvenile pilocytic astrocytoma, is related to dysembryoplastic neuroepithelial tumor and oligodendroglioma. An important gene associated with Pilocytic Astrocytoma is KIAA1549 (KIAA1549), and among its related pathways are Long-term depression and Signalling to ERKs. The compounds regorafenib and sorafenib have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and cerebellum, and related mouse phenotypes are pigmentation and embryogenesis.

Wikipedia:65 Pilocytic astrocytoma or juvenile pilocytic astrocytoma or cystic cerebellar astrocytoma (and its... more...

Aliases & Classifications for Pilocytic Astrocytoma

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Sources:
42NIH Rare Diseases, 62UMLS, 10DISEASES, 44Novoseek, 48Orphanet, 63UMLS via Orphanet
See all sources

Pilocytic Astrocytoma, Aliases & Descriptions:

Name: Pilocytic Astrocytoma 42 10 44 48 62
 
Juvenile Pilocytic Astrocytoma 42 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
pilocytic astrocytoma:
Inheritance: Sporadic; Age of onset: Variable


External Ids:

UMLS via Orphanet63 C0334583

Related Diseases for Pilocytic Astrocytoma

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Diseases in the Pilocytic Astrocytoma family:

Juvenile Pilocytic Astrocytoma

Diseases related to Pilocytic Astrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1dysembryoplastic neuroepithelial tumor31.4SYP, KIAA1549
2oligodendroglioma31.3GFAP, BRAF
3neurofibromatosis31.2RAF1, S100B, KRAS
4gliosarcoma31.0GFAP, PDGFRB
5meningioma31.0S100B, GFAP, SYP, PDGFRB, TNC
6myxopapillary ependymoma30.9S100B, GFAP
7choroid plexus carcinoma30.9S100B, GFAP
8glioblastoma multiforme30.8NES, TNC, PDGFRB, THBS1, GFAP
9hemangioblastoma30.7NES, SYP, S100B, GFAP
10anaplastic oligodendroglioma30.6GFAP, LGALS3
11ependymoma30.6GFAP, DCX, NES, SYP, TIMP3, S100B
12medulloblastoma30.6S100B, GFAP, SYP, NTRK2, NES, TIMP3
13astrocytoma30.6NES, TIMP3, TNC, GFAP, IDH1, THBS1
14noonan syndrome30.5BRAF, RAF1, KRAS
15ganglioglioma30.3S100B, NTRK2, DCX, SYP, APOD, GFAP
16leukemia30.0RAF1, FGFR1, KRAS, PDGFRB, IDH1, NES
17glioblastoma29.3NES, LGALS3, NTRK2, PDGFRB, RAF1, S100B
18adenocarcinoma28.5KRAS, TNC, TIMP3, NES, THBS1, LGALS3
19malignant glioma28.0APOD, GFAP, TNC, TIMP3, SOX10, BRAF
20juvenile pilocytic astrocytoma11.0
21giant cell glioblastoma10.6GFAP
22gliomatosis cerebri10.6GFAP
23medulloepithelioma10.5SYP
24pilocytic astrocytoma of cerebellum10.5
25childhood pilocytic astrocytoma10.5
26melanotic neuroectodermal tumor10.5SYP
27binswanger's disease10.5SYP, GFAP
28central neurocytoma10.4GFAP, SYP
29male breast cancer10.4SYP, APOD
30pilomyxoid astrocytoma10.4
31cerebritis10.4
32endotheliitis10.4
33gemistocytic astrocytoma10.4S100B, GFAP
34subependymal giant cell astrocytoma10.4S100B, SYP
35olfactory neuroblastoma10.4SYP, S100B
36anaplastic ependymoma10.4S100B, GFAP
37choroid plexus papilloma10.4GFAP
38clear cell sarcoma10.4S100B, BRAF
39pleomorphic adenoma10.4TNC, S100B, GFAP
40proliferative vitreoretinopathy10.4TNC, GFAP, THBS1
41papillary ependymoma10.4S100B, SYP, GFAP
42syringoma10.4S100B, GFAP
43pineocytoma10.4GFAP, SYP, S100B
44cardiofaciocutaneous syndrome10.3KRAS, BRAF
45vascular cancer10.3PDGFRB, THBS1
46amelanotic melanoma10.3THBS1, S100B
47ganglioneuroblastoma10.3SYP, S100B
48pineoblastoma10.3GFAP, SYP
49paraganglioma10.3GFAP, S100B, SYP
50gastrointestinal stromal tumor10.3S100B, PDGFRB, NES

Graphical network of the top 20 diseases related to Pilocytic Astrocytoma:



Diseases related to pilocytic astrocytoma

Symptoms for Pilocytic Astrocytoma

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Drugs & Therapeutics for Pilocytic Astrocytoma

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Drug clinical trials:

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Search NIH Clinical Center for Pilocytic Astrocytoma

Genetic Tests for Pilocytic Astrocytoma

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Anatomical Context for Pilocytic Astrocytoma

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MalaCards organs/tissues related to Pilocytic Astrocytoma:

32
Brain, Spinal cord, Cerebellum, Pineal, Endothelial, Ovary, Temporal lobe, Tongue, Bone, Retina, Breast, Hypothalamus, Medulla oblongata, Pituitary

Animal Models for Pilocytic Astrocytoma or affiliated genes

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MGI Mouse Phenotypes related to Pilocytic Astrocytoma:

36 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.6KRAS, BRAF, SOX10, TIMP3
2MP:00053809.0SOX10, BRAF, NES, PDGFRB, RAF1, KRAS
3MP:00053678.9THBS1, TIMP3, BRAF, LGALS3, PDGFRB, KRAS
4MP:00053908.8THBS1, BRAF, LGALS3, NTRK2, PDGFRB, RAF1
5MP:00053888.8THBS1, TIMP3, SOX10, BRAF, LGALS3, NTRK2
6MP:00053698.7THBS1, GFAP, TIMP3, BRAF, PDGFRB, RAF1
7MP:00053798.7THBS1, TIMP3, SOX10, BRAF, NTRK2, PDGFRB
8MP:00053818.6THBS1, GFAP, SOX10, BRAF, LGALS3, PDGFRB
9MP:00053918.6THBS1, GFAP, TIMP3, BRAF, NTRK2, PDGFRB
10MP:00053898.3THBS1, DCX, BRAF, LGALS3, NTRK2, PDGFRB
11MP:00028738.3GFAP, TNC, SOX10, BRAF, NTRK2, SYP
12MP:00053978.3THBS1, IDH1, TIMP3, BRAF, LGALS3, PDGFRB
13MP:00053858.2THBS1, GFAP, APOD, TIMP3, BRAF, LGALS3
14MP:00107718.1BRAF, SOX10, TIMP3, THBS1, LGALS3, PDGFRB
15MP:00053878.1THBS1, IDH1, GFAP, TIMP3, BRAF, LGALS3
16MP:00053787.9SOX10, DCX, TIMP3, GFAP, THBS1, BRAF
17MP:00053847.8BRAF, SOX10, TIMP3, GFAP, THBS1, NES
18MP:00053867.7SOX10, DCX, TIMP3, APOD, TNC, GFAP
19MP:00036317.4FGFR1, GFAP, TNC, APOD, DCX, SOX10
20MP:00053767.4TIMP3, APOD, TNC, GFAP, IDH1, THBS1
21MP:00107687.2SOX10, DCX, TIMP3, APOD, GFAP, THBS1

Publications for Pilocytic Astrocytoma

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Articles related to Pilocytic Astrocytoma:

(show top 50)    (show all 310)
idTitleAuthorsYear
1
Anaplastic pilocytic astrocytoma. (24954244)
2014
2
A pilocytic astrocytoma mimicking a clinoidal meningioma. (24744944)
2014
3
A case of central precocious puberty due to concomitant hypothalamic hamartoma and juvenile pilocytic astrocytoma. (25241615)
2014
4
A 10year retrospective study of surgical outcomes of adult intracranial pilocytic astrocytoma. (25065843)
2014
5
Transformation of adult cerebellar pilocytic astrocytoma to glioblastoma. (23884731)
2013
6
Differential expression of the tumor suppressor A-kinase anchor protein 12 in human diffuse and pilocytic astrocytomas is regulated by promoter methylation. (24042196)
2013
7
Cerebellar metastasis from serous adenocarcinoma of the ovary mimicking pilocytic astrocytoma. (23293670)
2012
8
Juvenile pilocytic astrocytoma in association with arteriovenous malformation. (22681727)
2012
9
MAPK pathway activation in pilocytic astrocytoma. (22159586)
2012
10
Pilocytic astrocytoma with extensive psammomatous calcification in the lateral ventricle: a case report. (22167267)
2012
11
Vascular endothelial growth factor receptor 2 (VEGFR-2) signalling activity in paediatric pilocytic astrocytoma is restricted to tumour endothelial cells. (21208252)
2011
12
Primary cerebellar pilocytic astrocytoma with anaplastic features in a patient with neurofibromatosis type 1 - case report - . (21515958)
2011
13
An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice. (21403401)
2011
14
Proteomics studies of childhood pilocytic astrocytoma. (21466243)
2011
15
Immune cell infiltrate differences in pilocytic astrocytoma and glioblastoma: evidence of distinct immunological microenvironments that reflect tumor biology. (21663411)
2011
16
Magnetic resonance imaging features of pilocytic astrocytoma of the brain mimicking high-grade gliomas. (20657231)
2010
17
Management of intramedullary cystic pilocytic astrocytoma with rhenium-186 intracavitary irradiation: case report. (20404673)
2010
18
Acute v pattern esotropia without abduction deficit, secondary to a posterior fossa pilocytic astrocytoma. (19645405)
2009
19
Somatic mitochondrial mutations in pilocytic astrocytoma. (19480934)
2009
20
Histopathologic predictors of pilocytic astrocytoma event-free survival. (19271226)
2009
21
Real-time quantitative polymerase chain reaction (qPCR) analysis with fluorescence resonance energy transfer (FRET) probes reveals differential expression of the four ERBB4 juxtamembrane region variants between medulloblastoma and pilocytic astrocytoma. (19017278)
2009
22
Long-term functional outcome of surgical treatment of juvenile pilocytic astrocytoma of the cerebellum in children. (19418058)
2009
23
Diurnally fluctuating frontal dysequilibrium secondary to a pineal pilocytic astrocytoma: is this symptom associated with a check-valve mechanism in a pineal region tumor? (18972117)
2009
24
Cerebellar pilocytic astrocytoma presenting with intratumor bleeding, subarachnoid hemorrhage, and subdural hematoma. (18629510)
2009
25
Calcified pilocytic astrocytoma of the medulla mimicking a brainstem "stone". (19253601)
2008
26
Pilocytic astrocytoma with spontaneous intracranial hemorrhages in an elderly adult. (16621238)
2007
27
Occurrence of a spinal anaplastic pilocytic astrocytoma and a supratentorial PNET in an adolescent. (18090931)
2007
28
Paired overexpression of ErbB3 and Sox10 in pilocytic astrocytoma. (16896310)
2006
29
Large cystic cavernous angioma of the cerebellum mimicking pilocytic astrocytoma. (16821089)
2006
30
Disseminated pilocytic astrocytoma involving brain stem and diencephalon: a history of atypical eating disorder and diagnostic delay. (16598421)
2006
31
Radical resection for intrinsic midbrain pilocytic astrocytoma: report of two cases. (15309583)
2005
32
No aberrant methylation of neurofibromatosis 1 gene (NF1) promoter in pilocytic astrocytoma in childhood. (15770836)
2005
33
Exophytic pilocytic astrocytoma of the brain stem in an adult with encasement of the caudal cranial nerve complex (IX-XII): presurgical anatomical neuroimaging using MRI. (14740164)
2004
34
Juvenile pilocytic astrocytoma 'pilomyxoid variant' with spinal metastases. (15261239)
2004
35
Juvenile pilocytic astrocytoma. (12880155)
2003
36
Mutational and expression analysis of the NF1 gene argues against a role as tumor suppressor in sporadic pilocytic astrocytomas. (12387455)
2002
37
Pilocytic astrocytomas do not show most of the genetic changes commonly seen in diffuse astrocytomas. (11119125)
2000
38
Involution of diencephalic pilocytic astrocytoma after partial resection. Report of two cases in adults. (10969949)
2000
39
Low grade pilocytic astrocytoma presenting as a spontaneous intracerebral haemorrhage in a child. (11013653)
1998
40
Hypothalamic pilocytic astrocytoma presenting with intratumoral and subarachnoid hemorrhage. (9414929)
1997
41
Expression of vascular endothelial growth factor and its receptors in pilocytic astrocytoma. (9255258)
1997
42
Transient amnestic syndrome after spontaneous haemorrhage into a hypothalamic pilocytic astrocytoma. (7608691)
1995
43
The significance of atypia and histologic malignancy in pilocytic astrocytoma of the cerebellum: a clinicopathologic and flow cytometric study. (7930411)
1994
44
Fatal hemorrhage in a cerebral pilocytic astrocytoma-adult type. (1882644)
1991
45
Metastatic juvenile pilocytic astrocytoma. Case report. (1941128)
1991
46
Treatment results of juvenile pilocytic astrocytoma. (3392563)
1988
47
Anaplastic evolution of childhood optico-hypothalamic pilocytic astrocytoma: report of an autopsy case. (3208464)
1988
48
Cerebral pilocytic astrocytoma. (4016701)
1985
49
Pilocytic astrocytoma of the optic nerve with hemorrhage and extreme cystic degeneration. (7304696)
1981
50
Malignant evolution of childhood chiasmal pilocytic astrocytoma. (944389)
1976

Variations for Pilocytic Astrocytoma

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Expression for genes affiliated with Pilocytic Astrocytoma

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Expression patterns in normal tissues for genes affiliated with Pilocytic Astrocytoma

Search GEO for disease gene expression data for Pilocytic Astrocytoma.

Pathways for genes affiliated with Pilocytic Astrocytoma

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Pathways related to Pilocytic Astrocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0BRAF, RAF1, KRAS
2
Show member pathways
10.0KRAS, BRAF, RAF1
310.0KRAS, RAF1, BRAF
4
Show member pathways
10.0BRAF, KRAS, RAF1
510.0KRAS, BRAF, RAF1
610.0BRAF, KRAS, RAF1
7
Show member pathways
10.0KRAS, RAF1, FGFR1
89.8BRAF, RAF1, PDGFRB
9
Show member pathways
9.8FGFR1, KRAS, RAF1, BRAF
109.8FGFR1, PDGFRB, NTRK2
119.7TNC, FGFR1, THBS1
12
Show member pathways
MAPK Cascade37
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway37
9.7RAF1, TIMP3, BRAF, KRAS
13
Show member pathways
9.7KRAS, RAF1, FGFR1, TIMP3
14
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
9.7KRAS, PDGFRB, RAF1, BRAF
15
Show member pathways
9.7BRAF, KRAS, RAF1, PDGFRB
16
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
9.7KRAS, RAF1, BRAF, PDGFRB
179.6FGFR1, NTRK2, PDGFRB, KRAS
18
Show member pathways
9.6KRAS, PDGFRB, NTRK2, FGFR1
19
Show member pathways
9.6RAF1, FGFR1, NTRK2, PDGFRB
209.5KRAS, FGFR1, THBS1, RAF1
21
Show member pathways
9.5DCX, FGFR1, KRAS, RAF1, SRGAP3
22
Show member pathways
9.5BRAF, PDGFRB, RAF1, KRAS, FGFR1
239.5RAF1, FGFR1, BRAF, PDGFRB, KRAS
24
Show member pathways
9.5PDGFRB, FGFR1, KRAS, RAF1, BRAF
259.5TNC, TIMP3, FGFR1, PDGFRB
26
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.5BRAF, NTRK2, PDGFRB, RAF1, KRAS
27
Show member pathways
9.5PDGFRB, NTRK2, BRAF, RAF1, FGFR1
28
Show member pathways
9.5FGFR1, BRAF, PDGFRB, RAF1, NTRK2
29
Show member pathways
9.3TIMP3, NTRK2, FGFR1, RAF1, PDGFRB
30
Show member pathways
9.3TIMP3, RAF1, PDGFRB, FGFR1, NTRK2
31
Show member pathways
9.3FGFR1, TIMP3, NTRK2, PDGFRB, RAF1
32
Show member pathways
MAPK signaling pathway37
9.3KRAS, FGFR1, BRAF, NTRK2, PDGFRB, RAF1
339.2BRAF, PDGFRB, IDH1, FGFR1, KRAS, RAF1
34
Show member pathways
Integrin-mediated cell adhesion37
Focal Adhesion37
9.2THBS1, TNC, BRAF, PDGFRB, RAF1
35
Show member pathways
9.2FGFR1, RAF1, PDGFRB, NTRK2, BRAF, TIMP3
36
Show member pathways
9.2TIMP3, NTRK2, RAF1, BRAF, PDGFRB, FGFR1
37
Show member pathways
9.2RAF1, FGFR1, BRAF, NTRK2, PDGFRB, TIMP3
38
Show member pathways
9.2NTRK2, PDGFRB, RAF1, BRAF, TIMP3, FGFR1
399.1BRAF, TIMP3, FGFR1, KRAS, RAF1, THBS1
40
Show member pathways
Signaling Pathways in Glioblastoma37
9.1THBS1, BRAF, PDGFRB, RAF1, KRAS, FGFR1
41
Show member pathways
9.1KRAS, FGFR1, RAF1, PDGFRB, BRAF, THBS1
429.0THBS1, TNC, RAF1, FGFR1, PDGFRB, KRAS
43
Show member pathways
9.0GFAP, PDGFRB, RAF1, S100B, FGFR1, KRAS
44
Show member pathways
9.0TNC, FGFR1, RAF1, PDGFRB, NTRK2, BRAF
458.9SYP, S100B, GFAP, TNC, DCX, NTRK2
468.9PDGFRB, KRAS, TIMP3, TNC, THBS1, RAF1
47
Show member pathways
8.9TIMP3, BRAF, NTRK2, PDGFRB, DCX, FGFR1
48
Show member pathways
8.9THBS1, BRAF, NTRK2, PDGFRB, RAF1, KRAS
49
Show member pathways
8.5RAF1, TNC, TIMP3, BRAF, NTRK2, GFAP
50
Show member pathways
8.1S100B, THBS1, FGFR1, KRAS, RAF1, PDGFRB

Compounds for genes affiliated with Pilocytic Astrocytoma

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Compounds related to Pilocytic Astrocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 107)
idCompoundScoreTop Affiliating Genes
1regorafenib50 1110.9FGFR1, KRAS, RAF1, PDGFRB, BRAF
2sorafenib44 50 1111.8RAF1, FGFR1, PDGFRB, BRAF
3o6-methylguanine449.7THBS1, BRAF, KRAS, TIMP3
4s 100449.7GFAP, SYP, S100B
5streptozotocin449.7GFAP, NES, RAF1, SYP
6kainate44 2810.5NTRK2, GFAP, NES, DCX, SYP
7imatinib44 50 1111.5RAF1, S100B, KRAS, FGFR1, BRAF, PDGFRB
8chondroitin sulfate44 2410.5FGFR1, THBS1, TIMP3, TNC, GFAP
9choline44 24 1111.4GFAP, RAF1, S100B, SYP, NES
10gaba449.3SYP, NTRK2, S100B, NES, TNC, GFAP
11formaldehyde44 2410.2GFAP, SYP, LGALS3, S100B, TNC
12bromodeoxyuridine449.2GFAP, FGFR1, S100B, PDGFRB, DCX, NES
13forskolin44 50 1111.2GFAP, BRAF, NTRK2, SYP, RAF1, S100B
14pd 98,059449.2TIMP3, FGFR1, RAF1, NTRK2, BRAF, THBS1
15dopamine44 28 24 1112.1GFAP, NES, NTRK2, SYP, RAF1, S100B
16agar449.0LGALS3, RAF1, THBS1, GFAP, BRAF, FGFR1
17cisplatin44 50 61 1112.0KRAS, GFAP, BRAF, PDGFRB, NTRK2, SYP
18hematoxylin448.9GFAP, LGALS3, SYP, S100B
19gtp44 289.9BRAF, THBS1, RAF1, S100B, SYP, KRAS
20phosphoinositide448.9BRAF, KRAS, NTRK2, LGALS3, THBS1, RAF1
21genistein44 28 61 2 24 1113.9TIMP3, THBS1, PDGFRB, SYP, FGFR1, RAF1
22methionine448.9S100B, PDGFRB, FGFR1, TIMP3, THBS1, GFAP
23fatty acid448.9BRAF, KRAS, S100B, LGALS3, APOD, IDH1
24glutamine448.8LGALS3, SYP, S100B, GFAP, IDH1, RAF1
25ly294002448.8KRAS, TIMP3, BRAF, PDGFRB, NTRK2, FGFR1
26heparin44 28 24 1111.8THBS1, TNC, FGFR1, S100B, TIMP3, LGALS3
27paclitaxel44 50 1110.7THBS1, GFAP, SOX10, BRAF, PDGFRB, KRAS
28h2o2448.6NTRK2, TNC, LGALS3, SYP, KRAS, FGFR1
29dexamethasone44 50 28 1111.5S100B, RAF1, TNC, THBS1, GFAP, TIMP3
30alanine448.5GFAP, PDGFRB, S100B, RAF1, NTRK2, LGALS3
31matrigel448.5PDGFRB, TIMP3, NES, THBS1, LGALS3, BRAF
32nitric oxide44 24 1110.5S100B, SYP, NTRK2, NES, THBS1, LGALS3
33wortmannin448.4RAF1, PDGFRB, BRAF, LGALS3, S100B, KRAS
34threonine448.4BRAF, THBS1, NTRK2, PDGFRB, RAF1, GFAP
35phosphatidylinositol448.4THBS1, TIMP3, BRAF, TNC, KRAS, FGFR1
36oligonucleotide448.4FGFR1, APOD, TIMP3, TNC, THBS1, BRAF
37oxygen44 249.2PDGFRB, THBS1, GFAP, TIMP3, NES, LGALS3
38glucose448.2FGFR1, THBS1, NES, S100B, PDGFRB, NTRK2
39testosterone44 61 24 1111.2THBS1, FGFR1, NTRK2, RAF1, PDGFRB, SYP
40glutamate448.1TNC, S100B, FGFR1, NES, NTRK2, IDH1
41cysteine448.0FGFR1, TNC, THBS1, GFAP, RAF1, PDGFRB
42paraffin447.6THBS1, GFAP, TNC, APOD, BRAF, NES
43progesterone44 28 61 24 1111.6PDGFRB, FGFR1, S100B, SYP, THBS1, GFAP
44serine447.6GFAP, TNC, DCX, BRAF, LGALS3, NTRK2
45calcium44 50 24 1110.4THBS1, TIMP3, DCX, BRAF, LGALS3, NTRK2
46tyrosine447.3BRAF, S100B, TIMP3, NES, NTRK2, SYP
47lipid447.3TNC, FGFR1, KRAS, S100B, PDGFRB, APOD
48retinoic acid44 248.1THBS1, GFAP, TNC, APOD, TIMP3, BRAF
49estrogen447.1APOD, TNC, GFAP, THBS1, TIMP3, BRAF
50vegf447.1FGFR1, KRAS, S100B, RAF1, PDGFRB, SYP

GO Terms for genes affiliated with Pilocytic Astrocytoma

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Cellular components related to Pilocytic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1presynaptic active zoneGO:04878610.0SYP, NTRK2
2extracellular matrixGO:0310129.1LGALS3, TIMP3, TNC, THBS1
3cytosolGO:0058298.5IDH1, GFAP, DCX, BRAF, SRGAP3, NTRK2

Biological processes related to Pilocytic Astrocytoma according to GeneCards/GeneDecks:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1peripheral nervous system axon regenerationGO:01401210.3TNC, APOD
2activation of MAPKK activityGO:00018610.3KRAS, RAF1, BRAF
3positive regulation of phospholipase C activityGO:01086310.2FGFR1, PDGFRB
4MAPK cascadeGO:00016510.2RAF1, KRAS, FGFR1
5positive regulation of MAP kinase activityGO:04340610.2FGFR1, KRAS, PDGFRB
6positive regulation of phosphatidylinositol 3-kinase signalingGO:01406810.1FGFR1, PDGFRB, NTRK2
7positive regulation of gene expressionGO:01062810.1TNC, BRAF, NTRK2, KRAS
8negative regulation of neuron apoptotic processGO:04352410.1BRAF, NES, NTRK2, KRAS
9negative regulation of focal adhesion assemblyGO:05189510.1APOD, THBS1
10oligodendrocyte differentiationGO:04870910.1NTRK2, SOX10
11wound healingGO:04206010.1RAF1, PDGFRB, TNC
12long-term synaptic potentiationGO:06029110.0S100B, NTRK2, GFAP
13positive regulation of calcium ion importGO:09028010.0LGALS3, PDGFRB
14Fc-epsilon receptor signaling pathwayGO:03809510.0PDGFRB, RAF1, KRAS, FGFR1
15epidermal growth factor receptor signaling pathwayGO:00717310.0PDGFRB, RAF1, KRAS, FGFR1
16neuron migrationGO:00176410.0FGFR1, NTRK2, DCX
17small GTPase mediated signal transductionGO:0072649.9BRAF, SRGAP3, RAF1, KRAS
18positive regulation of chemotaxisGO:0509219.9THBS1, PDGFRB
19fibroblast growth factor receptor signaling pathwayGO:0085439.9BRAF, PDGFRB, RAF1, KRAS, FGFR1
20regulation of neuronal synaptic plasticityGO:0481689.8SYP, S100B
21axon guidanceGO:0074119.8DCX, RAF1, KRAS, FGFR1
22neurotrophin TRK receptor signaling pathwayGO:0480119.7FGFR1, KRAS, RAF1, PDGFRB, NTRK2, BRAF
23negative regulation of apoptotic processGO:0430669.5THBS1, SOX10, BRAF, PDGFRB, RAF1
24central nervous system developmentGO:0074179.5DCX, NES, S100B
25extracellular matrix organizationGO:0301989.5THBS1, GFAP, TNC, LGALS3
26positive regulation of cell proliferationGO:0082849.4TNC, NTRK2, PDGFRB, S100B, KRAS, FGFR1
27innate immune responseGO:0450879.3LGALS3, PDGFRB, RAF1, S100B, KRAS, FGFR1
28cell migrationGO:0164779.3FGFR1, PDGFRB, THBS1

Molecular functions related to Pilocytic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitogen-activated protein kinase kinase bindingGO:03143410.1BRAF, RAF1
2small GTPase bindingGO:0312679.8BRAF, RAF1
3identical protein bindingGO:0428028.7THBS1, SOX10, BRAF, SYP, RAF1, S100B
4protein bindingGO:0055157.3THBS1, APOD, TIMP3, SOX10, KRAS, S100B

Products for genes affiliated with Pilocytic Astrocytoma

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Sources for Pilocytic Astrocytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet