MCID: PLC011
MIFTS: 57

Pilocytic Astrocytoma malady

Rare diseases, Neuronal diseases, Cancer diseases categories
Download this MalaCard

Summaries for Pilocytic Astrocytoma

About this section
Sources:
43NIH Rare Diseases, 65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
NIH Rare Diseases:43 Pilocytic astrocytoma is an often benign, slow-growing tumor of the brain or spinal cord. the tumor may be in the form of a cyst and usually does not spread to nearby tissues. symptoms vary depending upon the size and location of the tumor. most symptoms result from increased pressure on the brain and include headaches, nausea, vomiting, balance problems, and vision abnormalities. the underlying cause of a pilocytic astrocytoma is unknown. it most commonly occurs in children and young adults, and in people with neurofibromatosis type 1 (nf1), li-fraumeni syndrome, and tuberous sclerosis. this type of tumor can often be cured with surgery. last updated: 8/9/2013

MalaCards: Pilocytic Astrocytoma, also known as juvenile pilocytic astrocytoma, is related to astrocytoma and neurofibromatosis. An important gene associated with Pilocytic Astrocytoma is KIAA1549 (KIAA1549), and among its related pathways are Renal cell carcinoma and Signalling to ERKs. The compounds regorafenib and sorafenib have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and cerebellum, and related mouse phenotypes are pigmentation and embryogenesis.

Wikipedia:65 Pilocytic astrocytoma or juvenile pilocytic astrocytoma or cystic cerebellar astrocytoma (and its... more...

Aliases & Classifications for Pilocytic Astrocytoma

About this section
Sources:
43NIH Rare Diseases, 62UMLS, 10DISEASES, 45Novoseek, 49Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

49
pilocytic astrocytoma:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

pilocytic astrocytoma 43 10 45 49 62
juvenile pilocytic astrocytoma 43 62


External Ids:

SNOMED-CT via Orphanet59 128854008
UMLS via Orphanet63 C0334583

Related Diseases for Pilocytic Astrocytoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Pilocytic Astrocytoma family:

Juvenile Pilocytic Astrocytoma

Diseases related to Pilocytic Astrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 154)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma31.7IDH1, THBS1, GFAP, TNC, FGFR1, S100B
2neurofibromatosis31.1KRAS, S100B, RAF1
3oligodendroglioma30.9GFAP, BRAF
4medulloblastoma30.8GFAP, TIMP3, NES, NTRK2, SYP, S100B
5anaplastic astrocytoma30.7PDGFRB, LGALS3, NES, APOD, TNC, GFAP
6meningioma30.7S100B, PDGFRB, SYP, TNC, GFAP
7dysembryoplastic neuroepithelial tumor30.7KIAA1549, SYP
8glioblastoma multiforme30.5THBS1, GFAP, TNC, NES, PDGFRB
9ependymoma30.5GFAP, TIMP3, DCX, NES, SYP, S100B
10gliosarcoma30.4PDGFRB, GFAP
11ganglioglioma30.4S100B, SYP, NTRK2, DCX, APOD, GFAP
12myxopapillary ependymoma30.4S100B, GFAP
13choroid plexus carcinoma30.4S100B, GFAP
14hemangioblastoma30.4GFAP, NES, SYP, S100B
15leukemia30.4IDH1, NES, PDGFRB, RAF1, KRAS, FGFR1
16noonan syndrome30.3BRAF, RAF1, KRAS
17anaplastic oligodendroglioma30.3GFAP, LGALS3
18adenocarcinoma29.8THBS1, TNC, TIMP3, FGFR1, KRAS, RAF1
19malignant glioma29.7FGFR1, S100B, RAF1, PDGFRB, SYP, NTRK2
20juvenile pilocytic astrocytoma11.0
21pilocytic astrocytoma of cerebellum10.5
22childhood pilocytic astrocytoma10.5
23cerebritis10.4
24pilomyxoid astrocytoma10.4
25diffuse astrocytoma10.4
26autism spectrum disorder10.3
27cervicitis10.3
28craniopharyngioma10.3
29diencephalic syndrome10.3
30hemifacial spasm10.3
31tremor10.3
32endotheliitis10.3
33pituicytoma10.3
34siderosis10.2
35choroiditis10.2
36sensorineural hearing loss10.2
37trigonitis10.2
38gonadoblastoma10.2
39arteriovenous malformation10.2
40frasier syndrome10.2
41pleomorphic xanthoastrocytoma10.2
42obstructive hydrocephalus10.2
43albright's hereditary osteodystrophy10.2
44silver-russell syndrome10.2
45amblyopia10.2
46basal cell carcinoma10.2
47eating disorder10.2
48ectropion10.2
49esotropia10.2
50hydrocephalus10.2

Graphical network of the top 20 diseases related to Pilocytic Astrocytoma:



Diseases related to pilocytic astrocytoma

Symptoms for Pilocytic Astrocytoma

About this section

Drugs & Therapeutics for Pilocytic Astrocytoma

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Pilocytic Astrocytoma

Search NIH Clinical Center for Pilocytic Astrocytoma

Genetic Tests for Pilocytic Astrocytoma

About this section

Anatomical Context for Pilocytic Astrocytoma

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Pilocytic Astrocytoma:

33
Brain, Spinal cord, Cerebellum, Pineal, Tongue, Temporal lobe, Ovary, Endothelial, Hypothalamus, Pituitary, Retina, Breast, Bone, Medulla oblongata

Animal Models for Pilocytic Astrocytoma or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Pilocytic Astrocytoma:

37 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.6KRAS, BRAF, SOX10, TIMP3
2MP:00053809.0SOX10, BRAF, NES, PDGFRB, RAF1, KRAS
3MP:00053678.9THBS1, TIMP3, BRAF, LGALS3, PDGFRB, KRAS
4MP:00053908.8THBS1, BRAF, LGALS3, NTRK2, PDGFRB, RAF1
5MP:00053888.8THBS1, TIMP3, SOX10, BRAF, LGALS3, NTRK2
6MP:00053698.7THBS1, GFAP, TIMP3, BRAF, PDGFRB, RAF1
7MP:00053798.7THBS1, TIMP3, SOX10, BRAF, NTRK2, PDGFRB
8MP:00053818.6THBS1, GFAP, SOX10, BRAF, LGALS3, PDGFRB
9MP:00053918.6THBS1, GFAP, TIMP3, BRAF, NTRK2, PDGFRB
10MP:00053898.3THBS1, DCX, BRAF, LGALS3, NTRK2, PDGFRB
11MP:00028738.3GFAP, TNC, SOX10, BRAF, NTRK2, SYP
12MP:00053978.3THBS1, IDH1, TIMP3, BRAF, LGALS3, PDGFRB
13MP:00053858.2THBS1, GFAP, APOD, TIMP3, BRAF, LGALS3
14MP:00107718.1BRAF, SOX10, TIMP3, THBS1, LGALS3, PDGFRB
15MP:00053878.1THBS1, IDH1, GFAP, TIMP3, BRAF, LGALS3
16MP:00053787.9SOX10, DCX, TIMP3, GFAP, THBS1, BRAF
17MP:00053847.8BRAF, SOX10, TIMP3, GFAP, THBS1, NES
18MP:00053867.7SOX10, DCX, TIMP3, APOD, TNC, GFAP
19MP:00036317.4FGFR1, GFAP, TNC, APOD, DCX, SOX10
20MP:00053767.4TIMP3, APOD, TNC, GFAP, IDH1, THBS1
21MP:00107687.2SOX10, DCX, TIMP3, APOD, GFAP, THBS1

Publications for Pilocytic Astrocytoma

About this section
Sources:
52PubMed
See all sources

Articles related to Pilocytic Astrocytoma:

(show top 50)    (show all 288)
idTitleAuthorsYear
1
Transformation of adult cerebellar pilocytic astrocytoma to glioblastoma. (23884731)
2013
2
Metachronous, multicentric glioma of pilocytic astrocytoma with oligodendroglioma-like component and oligodendroglioma through distinct genetic aberrations. (23082883)
2013
3
Transsphenoidal removal of intrasellar pilocytic astrocytoma. (24308951)
2013
4
Cerebellar metastasis from serous adenocarcinoma of the ovary mimicking pilocytic astrocytoma. (23293670)
2012
5
Juvenile pilocytic astrocytoma in association with arteriovenous malformation. (22681727)
2012
6
MAPK pathway activation in pilocytic astrocytoma. (22159586)
2012
7
Pilocytic astrocytoma with extensive psammomatous calcification in the lateral ventricle: a case report. (22167267)
2012
8
Vascular endothelial growth factor receptor 2 (VEGFR-2) signalling activity in paediatric pilocytic astrocytoma is restricted to tumour endothelial cells. (21208252)
2011
9
Primary cerebellar pilocytic astrocytoma with anaplastic features in a patient with neurofibromatosis type 1 - case report - . (21515958)
2011
10
An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice. (21403401)
2011
11
Proteomics studies of childhood pilocytic astrocytoma. (21466243)
2011
12
Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. (21274720)
2011
13
Magnetic resonance imaging features of pilocytic astrocytoma of the brain mimicking high-grade gliomas. (20657231)
2010
14
Management of intramedullary cystic pilocytic astrocytoma with rhenium-186 intracavitary irradiation: case report. (20404673)
2010
15
Acute v pattern esotropia without abduction deficit, secondary to a posterior fossa pilocytic astrocytoma. (19645405)
2009
16
Somatic mitochondrial mutations in pilocytic astrocytoma. (19480934)
2009
17
Histopathologic predictors of pilocytic astrocytoma event-free survival. (19271226)
2009
18
Real-time quantitative polymerase chain reaction (qPCR) analysis with fluorescence resonance energy transfer (FRET) probes reveals differential expression of the four ERBB4 juxtamembrane region variants between medulloblastoma and pilocytic astrocytoma. (19017278)
2009
19
Long-term functional outcome of surgical treatment of juvenile pilocytic astrocytoma of the cerebellum in children. (19418058)
2009
20
Diurnally fluctuating frontal dysequilibrium secondary to a pineal pilocytic astrocytoma: is this symptom associated with a check-valve mechanism in a pineal region tumor? (18972117)
2009
21
Cerebellar pilocytic astrocytoma presenting with intratumor bleeding, subarachnoid hemorrhage, and subdural hematoma. (18629510)
2009
22
Calcified pilocytic astrocytoma of the medulla mimicking a brainstem "stone". (19253601)
2008
23
Pilocytic astrocytoma with spontaneous intracranial hemorrhages in an elderly adult. (16621238)
2007
24
Occurrence of a spinal anaplastic pilocytic astrocytoma and a supratentorial PNET in an adolescent. (18090931)
2007
25
Paired overexpression of ErbB3 and Sox10 in pilocytic astrocytoma. (16896310)
2006
26
Large cystic cavernous angioma of the cerebellum mimicking pilocytic astrocytoma. (16821089)
2006
27
Disseminated pilocytic astrocytoma involving brain stem and diencephalon: a history of atypical eating disorder and diagnostic delay. (16598421)
2006
28
Radical resection for intrinsic midbrain pilocytic astrocytoma: report of two cases. (15309583)
2005
29
No aberrant methylation of neurofibromatosis 1 gene (NF1) promoter in pilocytic astrocytoma in childhood. (15770836)
2005
30
Exophytic pilocytic astrocytoma of the brain stem in an adult with encasement of the caudal cranial nerve complex (IX-XII): presurgical anatomical neuroimaging using MRI. (14740164)
2004
31
Juvenile pilocytic astrocytoma 'pilomyxoid variant' with spinal metastases. (15261239)
2004
32
Juvenile pilocytic astrocytoma. (12880155)
2003
33
Mutational and expression analysis of the NF1 gene argues against a role as tumor suppressor in sporadic pilocytic astrocytomas. (12387455)
2002
34
Case report: Hemispheric juvenile pilocytic astrocytoma with extreme exophytic growth. (11384146)
2001
35
Pilocytic astrocytomas do not show most of the genetic changes commonly seen in diffuse astrocytomas. (11119125)
2000
36
Involution of diencephalic pilocytic astrocytoma after partial resection. Report of two cases in adults. (10969949)
2000
37
Dorsally exophytic brain stem tumors: total removal of a medullary pilocytic astrocytoma in child. Clinicopathological considerations and case report. (10864393)
1999
38
Low grade pilocytic astrocytoma presenting as a spontaneous intracerebral haemorrhage in a child. (11013653)
1998
39
Hypothalamic pilocytic astrocytoma presenting with intratumoral and subarachnoid hemorrhage. (9414929)
1997
40
Expression of vascular endothelial growth factor and its receptors in pilocytic astrocytoma. (9255258)
1997
41
Management of pilocytic astrocytoma. (9007882)
1996
42
Transient amnestic syndrome after spontaneous haemorrhage into a hypothalamic pilocytic astrocytoma. (7608691)
1995
43
The significance of atypia and histologic malignancy in pilocytic astrocytoma of the cerebellum: a clinicopathologic and flow cytometric study. (7930411)
1994
44
Fatal hemorrhage in a cerebral pilocytic astrocytoma-adult type. (1882644)
1991
45
Metastatic juvenile pilocytic astrocytoma. Case report. (1941128)
1991
46
Treatment results of juvenile pilocytic astrocytoma. (3392563)
1988
47
Anaplastic evolution of childhood optico-hypothalamic pilocytic astrocytoma: report of an autopsy case. (3208464)
1988
48
Cerebral pilocytic astrocytoma. (4016701)
1985
49
Pilocytic astrocytoma of the optic nerve with hemorrhage and extreme cystic degeneration. (7304696)
1981
50
Malignant evolution of childhood chiasmal pilocytic astrocytoma. (944389)
1976

Variations for Pilocytic Astrocytoma

About this section

Expression for genes affiliated with Pilocytic Astrocytoma

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pilocytic Astrocytoma

Search GEO for disease gene expression data for Pilocytic Astrocytoma.

Pathways for genes affiliated with Pilocytic Astrocytoma

About this section
Sources:
50PathCards, 30KEGG, 55Reactome, 60Thomson Reuters, 54R&D Systems, 53QIAGEN, 38NCBI BioSystems Database, 51PharmGKB, 57SinoBiological, 61Tocris Bioscience, 5Cell Signaling Technology
See all sources

Pathways related to Pilocytic Astrocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0KRAS, RAF1, BRAF
2
Show member pathways
10.0BRAF, RAF1, KRAS
3
Show member pathways
10.0BRAF, RAF1, KRAS
410.0BRAF, RAF1, KRAS
510.0BRAF, RAF1, KRAS
610.0BRAF, RAF1, KRAS
7
Show member pathways
10.0FGFR1, KRAS, RAF1
89.8RAF1, PDGFRB, BRAF
9
Show member pathways
9.8FGFR1, KRAS, RAF1, BRAF
109.8FGFR1, PDGFRB, NTRK2
119.7FGFR1, TNC, THBS1
12
Show member pathways
MAPK Cascade38
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway38
9.7KRAS, RAF1, BRAF, TIMP3
13
Show member pathways
9.7FGFR1, KRAS, RAF1, TIMP3
14
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
9.7KRAS, RAF1, PDGFRB, BRAF
15
Show member pathways
9.7KRAS, RAF1, PDGFRB, BRAF
16
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
9.7KRAS, RAF1, PDGFRB, BRAF
17
Show member pathways
9.6FGFR1, KRAS, PDGFRB, NTRK2
189.6NTRK2, PDGFRB, KRAS, FGFR1
19
Show member pathways
9.6NTRK2, PDGFRB, RAF1, FGFR1
209.5THBS1, RAF1, KRAS, FGFR1
21
Show member pathways
9.5DCX, SRGAP3, RAF1, KRAS, FGFR1
22
Show member pathways
9.5BRAF, PDGFRB, RAF1, KRAS, FGFR1
239.5FGFR1, KRAS, RAF1, PDGFRB, BRAF
24
Show member pathways
9.5FGFR1, KRAS, RAF1, PDGFRB, BRAF
259.5FGFR1, PDGFRB, TIMP3, TNC
26
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.5BRAF, NTRK2, PDGFRB, RAF1, KRAS
27
Show member pathways
9.5FGFR1, RAF1, PDGFRB, NTRK2, BRAF
28
Show member pathways
9.5FGFR1, RAF1, PDGFRB, NTRK2, BRAF
29
Show member pathways
9.3TIMP3, NTRK2, PDGFRB, RAF1, FGFR1
30
Show member pathways
9.3TIMP3, NTRK2, PDGFRB, RAF1, FGFR1
31
Show member pathways
9.3TIMP3, NTRK2, PDGFRB, RAF1, FGFR1
32
Show member pathways
MAPK signaling pathway38
9.3BRAF, NTRK2, PDGFRB, RAF1, KRAS, FGFR1
339.2FGFR1, KRAS, RAF1, PDGFRB, BRAF, IDH1
34
Show member pathways
Integrin-mediated cell adhesion38
Focal Adhesion38
9.2THBS1, TNC, BRAF, PDGFRB, RAF1
35
Show member pathways
9.2TIMP3, BRAF, NTRK2, PDGFRB, RAF1, FGFR1
36
Show member pathways
9.2TIMP3, BRAF, NTRK2, PDGFRB, RAF1, FGFR1
37
Show member pathways
9.2TIMP3, BRAF, NTRK2, PDGFRB, RAF1, FGFR1
38
Show member pathways
9.2TIMP3, BRAF, NTRK2, PDGFRB, RAF1, FGFR1
399.1THBS1, TIMP3, BRAF, RAF1, KRAS, FGFR1
40
Show member pathways
9.1THBS1, BRAF, PDGFRB, RAF1, KRAS, FGFR1
41
Show member pathways
Signaling Pathways in Glioblastoma38
9.1THBS1, BRAF, PDGFRB, RAF1, KRAS, FGFR1
429.0THBS1, TNC, PDGFRB, RAF1, KRAS, FGFR1
43
Show member pathways
9.0GFAP, PDGFRB, RAF1, S100B, KRAS, FGFR1
44
Show member pathways
9.0TNC, TIMP3, BRAF, NTRK2, PDGFRB, RAF1
458.9GFAP, TNC, DCX, NTRK2, SYP, S100B
468.9THBS1, TNC, TIMP3, PDGFRB, RAF1, KRAS
47
Show member pathways
8.9TIMP3, DCX, BRAF, NTRK2, PDGFRB, RAF1
48
Show member pathways
8.9THBS1, BRAF, NTRK2, PDGFRB, RAF1, KRAS
49
Show member pathways
8.5GFAP, TNC, TIMP3, SOX10, BRAF, NTRK2
50
Show member pathways
8.1THBS1, GFAP, BRAF, SRGAP3, NTRK2, PDGFRB

Compounds for genes affiliated with Pilocytic Astrocytoma

About this section
Sources:
51PharmGKB, 11DrugBank, 45Novoseek, 29IUPHAR, 24HMDB, 61Tocris Bioscience, 3BitterDB
See all sources

Compounds related to Pilocytic Astrocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 107)
idCompoundScoreTop Affiliating Genes
1regorafenib51 1110.9BRAF, PDGFRB, RAF1, KRAS, FGFR1
2sorafenib45 51 1111.8BRAF, PDGFRB, RAF1, FGFR1
3o6-methylguanine459.7KRAS, BRAF, TIMP3, THBS1
4s 100459.7S100B, SYP, GFAP
5streptozotocin459.7GFAP, NES, SYP, RAF1
6kainate45 2910.5GFAP, DCX, NES, NTRK2, SYP
7imatinib45 51 1111.5BRAF, PDGFRB, RAF1, S100B, KRAS, FGFR1
8chondroitin sulfate45 2410.5THBS1, GFAP, TNC, TIMP3, FGFR1
9choline45 24 1111.4GFAP, NES, SYP, RAF1, S100B
10gaba459.3GFAP, TNC, NES, NTRK2, SYP, S100B
11formaldehyde45 2410.2S100B, SYP, LGALS3, TNC, GFAP
12bromodeoxyuridine459.2GFAP, DCX, NES, PDGFRB, S100B, FGFR1
13forskolin45 51 1111.2GFAP, BRAF, NTRK2, SYP, RAF1, S100B
14pd 98,059459.2THBS1, GFAP, TIMP3, BRAF, NTRK2, RAF1
15dopamine45 29 24 1112.1GFAP, NES, NTRK2, SYP, RAF1, S100B
16agar459.0THBS1, GFAP, BRAF, LGALS3, PDGFRB, RAF1
17cisplatin45 51 61 1112.0GFAP, BRAF, LGALS3, NTRK2, SYP, PDGFRB
18hematoxylin458.9GFAP, LGALS3, SYP, S100B
19gtp45 299.9THBS1, BRAF, SYP, RAF1, S100B, KRAS
20phosphoinositide458.9THBS1, TNC, BRAF, LGALS3, NTRK2, PDGFRB
21genistein45 29 61 3 24 1113.9THBS1, GFAP, TIMP3, SYP, PDGFRB, RAF1
22methionine458.9THBS1, GFAP, TIMP3, PDGFRB, S100B, FGFR1
23fatty acid458.9IDH1, APOD, BRAF, LGALS3, S100B, KRAS
24glutamine458.8IDH1, GFAP, TIMP3, LGALS3, SYP, RAF1
25ly294002458.8THBS1, TNC, TIMP3, BRAF, NTRK2, PDGFRB
26heparin45 29 24 1111.8THBS1, TNC, TIMP3, LGALS3, RAF1, S100B
27paclitaxel45 51 1110.7THBS1, GFAP, SOX10, BRAF, PDGFRB, RAF1
28h2o2458.6THBS1, TNC, LGALS3, NTRK2, SYP, PDGFRB
29dexamethasone45 51 29 1111.5THBS1, GFAP, TNC, TIMP3, SYP, RAF1
30alanine458.5THBS1, GFAP, BRAF, LGALS3, NTRK2, PDGFRB
31matrigel458.5THBS1, GFAP, TNC, TIMP3, BRAF, NES
32nitric oxide45 24 1110.5NES, LGALS3, NTRK2, SYP, S100B, FGFR1
33wortmannin458.4THBS1, TNC, TIMP3, BRAF, LGALS3, PDGFRB
34threonine458.4THBS1, GFAP, BRAF, LGALS3, NTRK2, PDGFRB
35phosphatidylinositol458.4BRAF, TIMP3, TNC, THBS1, LGALS3, NTRK2
36oligonucleotide458.4TIMP3, APOD, TNC, THBS1, BRAF, LGALS3
37oxygen45 249.2THBS1, GFAP, TIMP3, NES, LGALS3, NTRK2
38glucose458.2THBS1, GFAP, APOD, TIMP3, BRAF, NES
39testosterone45 61 24 1111.2THBS1, GFAP, APOD, TIMP3, NTRK2, SYP
40glutamate458.1IDH1, GFAP, TNC, TIMP3, BRAF, NES
41cysteine458.0THBS1, GFAP, TNC, TIMP3, LGALS3, SYP
42paraffin457.7KRAS, S100B, PDGFRB, SYP, LGALS3, NES
43progesterone45 29 61 24 1111.6SYP, LGALS3, NES, BRAF, TIMP3, APOD
44serine457.6BRAF, DCX, TNC, GFAP, THBS1, LGALS3
45calcium45 51 24 1110.4THBS1, IDH1, GFAP, TNC, TIMP3, DCX
46tyrosine457.3NES, BRAF, TIMP3, TNC, GFAP, THBS1
47lipid457.3BRAF, TIMP3, APOD, TNC, GFAP, THBS1
48retinoic acid45 248.1TNC, GFAP, THBS1, APOD, RAF1, PDGFRB
49estrogen457.1FGFR1, KRAS, S100B, RAF1, PDGFRB, SYP
50vegf457.1FGFR1, TIMP3, TNC, GFAP, THBS1, DCX

GO Terms for genes affiliated with Pilocytic Astrocytoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Pilocytic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1presynaptic active zoneGO:04878610.0SYP, NTRK2
2extracellular matrixGO:0310129.1LGALS3, TIMP3, TNC, THBS1
3cytosolGO:0058298.5IDH1, GFAP, DCX, BRAF, SRGAP3, NTRK2

Biological processes related to Pilocytic Astrocytoma according to GeneCards/GeneDecks:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1peripheral nervous system axon regenerationGO:01401210.3TNC, APOD
2activation of MAPKK activityGO:00018610.3KRAS, RAF1, BRAF
3positive regulation of phospholipase C activityGO:01086310.2FGFR1, PDGFRB
4MAPK cascadeGO:00016510.2RAF1, KRAS, FGFR1
5positive regulation of MAP kinase activityGO:04340610.2FGFR1, KRAS, PDGFRB
6positive regulation of phosphatidylinositol 3-kinase signalingGO:01406810.1FGFR1, PDGFRB, NTRK2
7positive regulation of gene expressionGO:01062810.1TNC, BRAF, NTRK2, KRAS
8negative regulation of neuron apoptotic processGO:04352410.1BRAF, NES, NTRK2, KRAS
9negative regulation of focal adhesion assemblyGO:05189510.1APOD, THBS1
10oligodendrocyte differentiationGO:04870910.1NTRK2, SOX10
11wound healingGO:04206010.1RAF1, PDGFRB, TNC
12long-term synaptic potentiationGO:06029110.0S100B, NTRK2, GFAP
13positive regulation of calcium ion importGO:09028010.0LGALS3, PDGFRB
14Fc-epsilon receptor signaling pathwayGO:03809510.0PDGFRB, RAF1, KRAS, FGFR1
15epidermal growth factor receptor signaling pathwayGO:00717310.0PDGFRB, RAF1, KRAS, FGFR1
16neuron migrationGO:00176410.0FGFR1, NTRK2, DCX
17small GTPase mediated signal transductionGO:0072649.9BRAF, SRGAP3, RAF1, KRAS
18positive regulation of chemotaxisGO:0509219.9THBS1, PDGFRB
19fibroblast growth factor receptor signaling pathwayGO:0085439.9BRAF, PDGFRB, RAF1, KRAS, FGFR1
20regulation of neuronal synaptic plasticityGO:0481689.8SYP, S100B
21axon guidanceGO:0074119.8DCX, RAF1, KRAS, FGFR1
22neurotrophin TRK receptor signaling pathwayGO:0480119.7FGFR1, KRAS, RAF1, PDGFRB, NTRK2, BRAF
23negative regulation of apoptotic processGO:0430669.5THBS1, SOX10, BRAF, PDGFRB, RAF1
24central nervous system developmentGO:0074179.5DCX, NES, S100B
25extracellular matrix organizationGO:0301989.5THBS1, GFAP, TNC, LGALS3
26positive regulation of cell proliferationGO:0082849.4TNC, NTRK2, PDGFRB, S100B, KRAS, FGFR1
27innate immune responseGO:0450879.3LGALS3, PDGFRB, RAF1, S100B, KRAS, FGFR1
28cell migrationGO:0164779.3FGFR1, PDGFRB, THBS1

Molecular functions related to Pilocytic Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitogen-activated protein kinase kinase bindingGO:03143410.1RAF1, BRAF
2small GTPase bindingGO:0312679.8RAF1, BRAF
3identical protein bindingGO:0428028.7FGFR1, THBS1, SOX10, BRAF, SYP, RAF1
4protein bindingGO:0055157.3THBS1, APOD, TIMP3, SOX10, BRAF, SRGAP3

Products for genes affiliated with Pilocytic Astrocytoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pilocytic Astrocytoma

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet