MCID: PLC011
MIFTS: 49

Pilocytic Astrocytoma malady

Rare diseases, Neuronal diseases, Cancer diseases categories

Aliases & Classifications for Pilocytic Astrocytoma

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Sources:
42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 61UMLS, 62UMLS via Orphanet
See all sources

Aliases & Descriptions for Pilocytic Astrocytoma:

Name: Pilocytic Astrocytoma 42 10 44 48 61
 
Juvenile Pilocytic Astrocytoma 42 61


Classifications:



Characteristics (Orphanet epidemiological data):

48
pilocytic astrocytoma:
Inheritance: Not applicable; Age of onset: All ages


External Ids:

Orphanet48 251612
UMLS via Orphanet62 C0334583

Summaries for Pilocytic Astrocytoma

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NIH Rare Diseases:42 Pilocytic astrocytoma is an often benign, slow-growing tumor of the brain or spinal cord. the tumor may be in the form of a cyst and usually does not spread to nearby tissues. symptoms vary depending upon the size and location of the tumor. most symptoms result from increased pressure on the brain and include headaches, nausea, vomiting, balance problems, and vision abnormalities. the underlying cause of a pilocytic astrocytoma is unknown. it most commonly occurs in children and young adults, and in people with neurofibromatosis type 1 (nf1), li-fraumeni syndrome, and tuberous sclerosis. this type of tumor can often be cured with surgery. last updated: 8/9/2013

MalaCards based summary: Pilocytic Astrocytoma, also known as juvenile pilocytic astrocytoma, is related to dysembryoplastic neuroepithelial tumor and oligodendroglioma. An important gene associated with Pilocytic Astrocytoma is KIAA1549 (KIAA1549), and among its related pathways are Long-term depression and Signalling to ERKs. The compounds regorafenib and sorafenib have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and cerebellum, and related mouse phenotypes are pigmentation and embryogenesis.

Wikipedia:64 Pilocytic astrocytoma or juvenile pilocytic astrocytoma or cystic cerebellar astrocytoma (and its... more...

Related Diseases for Pilocytic Astrocytoma

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Diseases in the Pilocytic Astrocytoma family:

Juvenile Pilocytic Astrocytoma

Diseases related to Pilocytic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1dysembryoplastic neuroepithelial tumor31.4KIAA1549, SYP
2oligodendroglioma31.4GFAP, BRAF
3neurofibromatosis31.2KRAS, S100B, RAF1
4gliosarcoma31.0PDGFRB, GFAP
5myxopapillary ependymoma30.9S100B, GFAP
6choroid plexus carcinoma30.9S100B, GFAP
7glioblastoma multiforme30.8THBS1, GFAP, TNC, NES, PDGFRB
8hemangioblastoma30.7GFAP, NES, SYP, S100B
9medulloblastoma30.6GFAP, TIMP3, NES, NTRK2, SYP, S100B
10ependymoma30.6GFAP, TIMP3, DCX, NES, SYP, S100B
11astrocytoma30.6IDH1, THBS1, GFAP, TNC, FGFR1, S100B
12anaplastic oligodendroglioma30.4GFAP, LGALS3
13ganglioglioma30.3S100B, SYP, NTRK2, DCX, APOD, GFAP
14leukemia30.0IDH1, NES, PDGFRB, RAF1, KRAS, FGFR1
15glioblastoma29.3FGFR1, S100B, RAF1, PDGFRB, NTRK2, LGALS3
16adenocarcinoma28.5THBS1, TNC, TIMP3, FGFR1, KRAS, RAF1
17malignant glioma28.0FGFR1, S100B, RAF1, PDGFRB, SYP, NTRK2
18juvenile pilocytic astrocytoma11.0
19giant cell glioblastoma10.6GFAP
20glomus tumor10.6SYP
21gliomatosis cerebri10.6GFAP
22pilocytic astrocytoma of cerebellum10.6
23childhood pilocytic astrocytoma10.6
24medulloepithelioma10.5SYP
25neurofibromatosis, type 110.5
26melanotic neuroectodermal tumor10.5SYP
27cerebritis10.5
28pilomyxoid astrocytoma10.5
29binswanger's disease10.5SYP, GFAP
30central neurocytoma10.4GFAP, SYP
31breast cancer10.4APOD, SYP
32endotheliitis10.4
33anaplastic ependymoma10.4GFAP, S100B
34gemistocytic astrocytoma10.4GFAP, S100B
35subependymal giant cell astrocytoma10.4SYP, S100B
36olfactory neuroblastoma10.4SYP, S100B
37choroid plexus papilloma10.4GFAP
38clear cell sarcoma10.4BRAF, S100B
39pleomorphic adenoma10.4GFAP, TNC, S100B
40vitreoretinopathy, neovascular inflammatory10.4THBS1, GFAP, TNC
41papillary ependymoma10.4GFAP, SYP, S100B
42syringoma10.4GFAP, S100B
43pineocytoma10.4GFAP, SYP, S100B
44cardiofaciocutaneous syndrome10.3BRAF, KRAS
45amelanotic melanoma10.3THBS1, S100B
46vascular cancer10.3THBS1, PDGFRB
47paraganglioma10.3GFAP, SYP, S100B
48autism spectrum disorder10.3
49cervicitis10.3
50craniopharyngioma10.3

Graphical network of the top 20 diseases related to Pilocytic Astrocytoma:



Diseases related to pilocytic astrocytoma

Symptoms for Pilocytic Astrocytoma

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Drugs & Therapeutics for Pilocytic Astrocytoma

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Drug clinical trials:

Search ClinicalTrials for Pilocytic Astrocytoma

Search NIH Clinical Center for Pilocytic Astrocytoma

Genetic Tests for Pilocytic Astrocytoma

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Anatomical Context for Pilocytic Astrocytoma

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MalaCards organs/tissues related to Pilocytic Astrocytoma:

31
Brain, Spinal cord, Cerebellum, Pineal, Endothelial, Ovary, Temporal lobe, Medulla oblongata, Tongue, Bone, Retina, Breast, Hypothalamus, Pituitary

Animal Models for Pilocytic Astrocytoma or affiliated genes

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MGI Mouse Phenotypes related to Pilocytic Astrocytoma:

35 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.6KRAS, BRAF, SOX10, TIMP3
2MP:00053809.0FGFR1, NES, KRAS, RAF1, PDGFRB, BRAF
3MP:00053678.9THBS1, TIMP3, BRAF, LGALS3, KRAS, PDGFRB
4MP:00053908.8NTRK2, LGALS3, BRAF, THBS1, FGFR1, RAF1
5MP:00053888.8TIMP3, KRAS, THBS1, RAF1, NTRK2, LGALS3
6MP:00053698.7GFAP, TIMP3, BRAF, PDGFRB, RAF1, FGFR1
7MP:00053798.7THBS1, TIMP3, SOX10, BRAF, PDGFRB, KRAS
8MP:00053818.6KRAS, PDGFRB, LGALS3, BRAF, SOX10, THBS1
9MP:00053918.6TIMP3, GFAP, THBS1, BRAF, FGFR1, NTRK2
10MP:00053898.3NTRK2, KRAS, PDGFRB, LGALS3, BRAF, DCX
11MP:00028738.3NTRK2, SOX10, TNC, S100B, PDGFRB, GFAP
12MP:00053978.3TIMP3, LGALS3, KRAS, RAF1, PDGFRB, THBS1
13MP:00053858.2RAF1, PDGFRB, LGALS3, BRAF, KRAS, FGFR1
14MP:00107718.1THBS1, TIMP3, SOX10, BRAF, KRAS, LGALS3
15MP:00053878.1RAF1, LGALS3, BRAF, TIMP3, GFAP, IDH1
16MP:00053787.9PDGFRB, RAF1, NTRK2, KRAS, FGFR1, BRAF
17MP:00053847.8NTRK2, SOX10, FGFR1, KRAS, RAF1, PDGFRB
18MP:00053867.7DCX, TIMP3, GFAP, APOD, TNC, SOX10
19MP:00036317.4NTRK2, FGFR1, KRAS, RAF1, PDGFRB, SYP
20MP:00053767.4APOD, TNC, GFAP, IDH1, THBS1, TIMP3
21MP:00107687.2TIMP3, THBS1, FGFR1, KRAS, RAF1, PDGFRB

Publications for Pilocytic Astrocytoma

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Articles related to Pilocytic Astrocytoma:

(show top 50)    (show all 320)
idTitleAuthorsYear
1
Long survival in a child with a mutated K27M-H3.3 pilocytic astrocytoma. (25909089)
2015
2
Anaplastic pilocytic astrocytoma. (24954244)
2014
3
A pilocytic astrocytoma mimicking a clinoidal meningioma. (24744944)
2014
4
A case of central precocious puberty due to concomitant hypothalamic hamartoma and juvenile pilocytic astrocytoma. (25241615)
2014
5
A 10year retrospective study of surgical outcomes of adult intracranial pilocytic astrocytoma. (25065843)
2014
6
Transformation of adult cerebellar pilocytic astrocytoma to glioblastoma. (23884731)
2013
7
Differential expression of the tumor suppressor A-kinase anchor protein 12 in human diffuse and pilocytic astrocytomas is regulated by promoter methylation. (24042196)
2013
8
Cerebellar metastasis from serous adenocarcinoma of the ovary mimicking pilocytic astrocytoma. (23293670)
2012
9
Juvenile pilocytic astrocytoma in association with arteriovenous malformation. (22681727)
2012
10
MAPK pathway activation in pilocytic astrocytoma. (22159586)
2012
11
Pilocytic astrocytoma with extensive psammomatous calcification in the lateral ventricle: a case report. (22167267)
2012
12
Vascular endothelial growth factor receptor 2 (VEGFR-2) signalling activity in paediatric pilocytic astrocytoma is restricted to tumour endothelial cells. (21208252)
2011
13
Primary cerebellar pilocytic astrocytoma with anaplastic features in a patient with neurofibromatosis type 1 - case report - . (21515958)
2011
14
An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice. (21403401)
2011
15
Proteomics studies of childhood pilocytic astrocytoma. (21466243)
2011
16
Immune cell infiltrate differences in pilocytic astrocytoma and glioblastoma: evidence of distinct immunological microenvironments that reflect tumor biology. (21663411)
2011
17
Magnetic resonance imaging features of pilocytic astrocytoma of the brain mimicking high-grade gliomas. (20657231)
2010
18
Management of intramedullary cystic pilocytic astrocytoma with rhenium-186 intracavitary irradiation: case report. (20404673)
2010
19
Acute v pattern esotropia without abduction deficit, secondary to a posterior fossa pilocytic astrocytoma. (19645405)
2009
20
Somatic mitochondrial mutations in pilocytic astrocytoma. (19480934)
2009
21
Histopathologic predictors of pilocytic astrocytoma event-free survival. (19271226)
2009
22
Real-time quantitative polymerase chain reaction (qPCR) analysis with fluorescence resonance energy transfer (FRET) probes reveals differential expression of the four ERBB4 juxtamembrane region variants between medulloblastoma and pilocytic astrocytoma. (19017278)
2009
23
Long-term functional outcome of surgical treatment of juvenile pilocytic astrocytoma of the cerebellum in children. (19418058)
2009
24
Diurnally fluctuating frontal dysequilibrium secondary to a pineal pilocytic astrocytoma: is this symptom associated with a check-valve mechanism in a pineal region tumor? (18972117)
2009
25
Cerebellar pilocytic astrocytoma presenting with intratumor bleeding, subarachnoid hemorrhage, and subdural hematoma. (18629510)
2009
26
Calcified pilocytic astrocytoma of the medulla mimicking a brainstem "stone". (19253601)
2008
27
Pilocytic astrocytoma with spontaneous intracranial hemorrhages in an elderly adult. (16621238)
2007
28
Occurrence of a spinal anaplastic pilocytic astrocytoma and a supratentorial PNET in an adolescent. (18090931)
2007
29
Paired overexpression of ErbB3 and Sox10 in pilocytic astrocytoma. (16896310)
2006
30
Large cystic cavernous angioma of the cerebellum mimicking pilocytic astrocytoma. (16821089)
2006
31
Disseminated pilocytic astrocytoma involving brain stem and diencephalon: a history of atypical eating disorder and diagnostic delay. (16598421)
2006
32
Radical resection for intrinsic midbrain pilocytic astrocytoma: report of two cases. (15309583)
2005
33
No aberrant methylation of neurofibromatosis 1 gene (NF1) promoter in pilocytic astrocytoma in childhood. (15770836)
2005
34
Exophytic pilocytic astrocytoma of the brain stem in an adult with encasement of the caudal cranial nerve complex (IX-XII): presurgical anatomical neuroimaging using MRI. (14740164)
2004
35
Juvenile pilocytic astrocytoma 'pilomyxoid variant' with spinal metastases. (15261239)
2004
36
Juvenile pilocytic astrocytoma. (12880155)
2003
37
Mutational and expression analysis of the NF1 gene argues against a role as tumor suppressor in sporadic pilocytic astrocytomas. (12387455)
2002
38
Pilocytic astrocytomas do not show most of the genetic changes commonly seen in diffuse astrocytomas. (11119125)
2000
39
Involution of diencephalic pilocytic astrocytoma after partial resection. Report of two cases in adults. (10969949)
2000
40
Low grade pilocytic astrocytoma presenting as a spontaneous intracerebral haemorrhage in a child. (11013653)
1998
41
Hypothalamic pilocytic astrocytoma presenting with intratumoral and subarachnoid hemorrhage. (9414929)
1997
42
Transient amnestic syndrome after spontaneous haemorrhage into a hypothalamic pilocytic astrocytoma. (7608691)
1995
43
The significance of atypia and histologic malignancy in pilocytic astrocytoma of the cerebellum: a clinicopathologic and flow cytometric study. (7930411)
1994
44
Fatal hemorrhage in a cerebral pilocytic astrocytoma-adult type. (1882644)
1991
45
Metastatic juvenile pilocytic astrocytoma. Case report. (1941128)
1991
46
Treatment results of juvenile pilocytic astrocytoma. (3392563)
1988
47
Anaplastic evolution of childhood optico-hypothalamic pilocytic astrocytoma: report of an autopsy case. (3208464)
1988
48
Cerebral pilocytic astrocytoma. (4016701)
1985
49
Pilocytic astrocytoma of the optic nerve with hemorrhage and extreme cystic degeneration. (7304696)
1981
50
Malignant evolution of childhood chiasmal pilocytic astrocytoma. (944389)
1976

Variations for Pilocytic Astrocytoma

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Expression for genes affiliated with Pilocytic Astrocytoma

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Search GEO for disease gene expression data for Pilocytic Astrocytoma.

Pathways for genes affiliated with Pilocytic Astrocytoma

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Pathways related to Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 59)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0BRAF, RAF1, KRAS
2
Show member pathways
10.0KRAS, BRAF, RAF1
310.0KRAS, RAF1, BRAF
4
Show member pathways
10.0BRAF, KRAS, RAF1
510.0KRAS, BRAF, RAF1
610.0BRAF, KRAS, RAF1
7
Show member pathways
10.0KRAS, RAF1, FGFR1
89.8BRAF, RAF1, PDGFRB
9
Show member pathways
9.8FGFR1, KRAS, RAF1, BRAF
109.8FGFR1, PDGFRB, NTRK2
119.7TNC, FGFR1, THBS1
12
Show member pathways
MAPK Cascade36
Immune response Oncostatin M signaling via MAPK in human cells59
Oncostatin M Signaling Pathway36
9.7RAF1, TIMP3, BRAF, KRAS
13
Show member pathways
9.7KRAS, RAF1, FGFR1, TIMP3
14
Show member pathways
Development EDNRB signaling59
Development ACM2 and ACM4 activation of ERK59
Cell adhesion Integrin inside out signaling59
Development G Proteins mediated regulation MARK ERK signaling59
Signal transduction IP3 signaling59
Development Angiotensin signaling via PYK259
Development EPO induced MAPK pathway59
9.7KRAS, PDGFRB, RAF1, BRAF
15
Show member pathways
9.7BRAF, KRAS, RAF1, PDGFRB
16
Show member pathways
Transcription Receptor mediated HIF regulation59
Development CNTF receptor signaling59
Class IB PI3K non-lipid kinase events36
ErbB2/ErbB3 signaling events36
Development Growth hormone signaling via PI3K AKT and MAPK cascades59
Translation Regulation activity of EIF259
Regulation of lipid metabolism Insulin signaling generic cascades59
Transcription PPAR Pathway59
Cell adhesion PLAU signaling59
Translation Regulation activity of EIF4F59
9.7KRAS, RAF1, BRAF, PDGFRB
179.6FGFR1, NTRK2, PDGFRB, KRAS
18
Show member pathways
9.6KRAS, PDGFRB, NTRK2, FGFR1
19
Show member pathways
9.6RAF1, FGFR1, NTRK2, PDGFRB
209.5KRAS, FGFR1, THBS1, RAF1
21
Show member pathways
9.5DCX, FGFR1, KRAS, RAF1, SRGAP3
22
Show member pathways
9.5BRAF, PDGFRB, RAF1, KRAS, FGFR1
239.5RAF1, FGFR1, BRAF, PDGFRB, KRAS
24
Show member pathways
9.5PDGFRB, FGFR1, KRAS, RAF1, BRAF
259.5TNC, TIMP3, FGFR1, PDGFRB
26
Show member pathways
Development EGFR signaling via PIP359
Development PDGF signaling via MAPK cascades59
Apoptosis and survival Anti apoptotic action of membrane bound ESR159
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases59
Development Neurotrophin family signaling59
Apoptosis and survival NGF signaling pathway59
Apoptosis and survival Role of CDK5 in neuronal death and survival59
9.5BRAF, NTRK2, PDGFRB, RAF1, KRAS
27
Show member pathways
9.5PDGFRB, NTRK2, BRAF, RAF1, FGFR1
28
Show member pathways
9.5FGFR1, BRAF, PDGFRB, RAF1, NTRK2
29
Show member pathways
9.3TIMP3, NTRK2, FGFR1, RAF1, PDGFRB
30
Show member pathways
9.3TIMP3, RAF1, PDGFRB, FGFR1, NTRK2
31
Show member pathways
9.3FGFR1, TIMP3, NTRK2, PDGFRB, RAF1
32
Show member pathways
MAPK signaling pathway36
9.3KRAS, FGFR1, BRAF, NTRK2, PDGFRB, RAF1
339.2BRAF, PDGFRB, IDH1, FGFR1, KRAS, RAF1
34
Show member pathways
Integrin-mediated cell adhesion36
Focal Adhesion36
9.2THBS1, TNC, BRAF, PDGFRB, RAF1
35
Show member pathways
9.2FGFR1, RAF1, PDGFRB, NTRK2, BRAF, TIMP3
36
Show member pathways
9.2TIMP3, NTRK2, RAF1, BRAF, PDGFRB, FGFR1
37
Show member pathways
9.2RAF1, FGFR1, BRAF, NTRK2, PDGFRB, TIMP3
38
Show member pathways
9.2NTRK2, PDGFRB, RAF1, BRAF, TIMP3, FGFR1
399.1BRAF, TIMP3, FGFR1, KRAS, RAF1, THBS1
40
Show member pathways
Signaling Pathways in Glioblastoma36
9.1THBS1, BRAF, PDGFRB, RAF1, KRAS, FGFR1
41
Show member pathways
9.1KRAS, FGFR1, RAF1, PDGFRB, BRAF, THBS1
429.0THBS1, TNC, RAF1, FGFR1, PDGFRB, KRAS
43
Show member pathways
9.0GFAP, PDGFRB, RAF1, S100B, FGFR1, KRAS
44
Show member pathways
9.0TNC, FGFR1, RAF1, PDGFRB, NTRK2, BRAF
458.9SYP, S100B, GFAP, TNC, DCX, NTRK2
468.9PDGFRB, KRAS, TIMP3, TNC, THBS1, RAF1
47
Show member pathways
8.9TIMP3, BRAF, NTRK2, PDGFRB, DCX, FGFR1
48
Show member pathways
8.9THBS1, BRAF, NTRK2, PDGFRB, RAF1, KRAS
49
Show member pathways
8.5RAF1, TNC, TIMP3, BRAF, NTRK2, GFAP
50
Show member pathways
8.1S100B, THBS1, FGFR1, KRAS, RAF1, PDGFRB

Compounds for genes affiliated with Pilocytic Astrocytoma

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Compounds related to Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 107)
idCompoundScoreTop Affiliating Genes
1regorafenib50 1110.9FGFR1, KRAS, RAF1, PDGFRB, BRAF
2sorafenib44 50 1111.8RAF1, FGFR1, PDGFRB, BRAF
3o6-methylguanine449.7THBS1, BRAF, KRAS, TIMP3
4s 100449.7GFAP, SYP, S100B
5streptozotocin449.7GFAP, NES, RAF1, SYP
6kainate44 2810.5NTRK2, GFAP, NES, DCX, SYP
7imatinib44 50 1111.5RAF1, S100B, KRAS, FGFR1, BRAF, PDGFRB
8chondroitin sulfate44 2410.5FGFR1, THBS1, TIMP3, TNC, GFAP
9choline44 24 1111.4GFAP, RAF1, S100B, SYP, NES
10gaba449.3SYP, NTRK2, S100B, NES, TNC, GFAP
11formaldehyde44 2410.2GFAP, SYP, LGALS3, S100B, TNC
12bromodeoxyuridine449.2GFAP, FGFR1, S100B, PDGFRB, DCX, NES
13forskolin44 50 1111.2GFAP, BRAF, NTRK2, SYP, RAF1, S100B
14pd 98,059449.2TIMP3, FGFR1, RAF1, NTRK2, BRAF, THBS1
15dopamine44 28 24 1112.1GFAP, NES, NTRK2, SYP, RAF1, S100B
16agar449.0LGALS3, RAF1, THBS1, GFAP, BRAF, FGFR1
17cisplatin44 50 60 1112.0KRAS, GFAP, BRAF, PDGFRB, NTRK2, SYP
18hematoxylin448.9GFAP, LGALS3, SYP, S100B
19gtp44 289.9BRAF, THBS1, RAF1, S100B, SYP, KRAS
20phosphoinositide448.9BRAF, KRAS, NTRK2, LGALS3, THBS1, RAF1
21genistein44 28 60 1 24 1113.9TIMP3, THBS1, PDGFRB, SYP, FGFR1, RAF1
22methionine448.9S100B, PDGFRB, FGFR1, TIMP3, THBS1, GFAP
23fatty acid448.9BRAF, KRAS, S100B, LGALS3, APOD, IDH1
24glutamine448.8LGALS3, SYP, S100B, GFAP, IDH1, RAF1
25ly294002448.8KRAS, TIMP3, BRAF, PDGFRB, NTRK2, FGFR1
26heparin44 28 24 1111.8THBS1, TNC, FGFR1, S100B, TIMP3, LGALS3
27paclitaxel44 50 1110.7THBS1, GFAP, SOX10, BRAF, PDGFRB, KRAS
28h2o2448.6NTRK2, TNC, LGALS3, SYP, KRAS, FGFR1
29dexamethasone44 50 28 1111.5S100B, RAF1, TNC, THBS1, GFAP, TIMP3
30alanine448.5GFAP, PDGFRB, S100B, RAF1, NTRK2, LGALS3
31matrigel448.5PDGFRB, TIMP3, NES, THBS1, LGALS3, BRAF
32nitric oxide44 24 1110.5S100B, SYP, NTRK2, NES, THBS1, LGALS3
33wortmannin448.4RAF1, PDGFRB, BRAF, LGALS3, S100B, KRAS
34threonine448.4BRAF, THBS1, NTRK2, PDGFRB, RAF1, GFAP
35phosphatidylinositol448.4THBS1, TIMP3, BRAF, TNC, KRAS, FGFR1
36oligonucleotide448.4FGFR1, APOD, TIMP3, TNC, THBS1, BRAF
37oxygen44 249.2PDGFRB, THBS1, GFAP, TIMP3, NES, LGALS3
38glucose448.2FGFR1, THBS1, NES, S100B, PDGFRB, NTRK2
39testosterone44 60 24 1111.2THBS1, FGFR1, NTRK2, RAF1, PDGFRB, SYP
40glutamate448.1TNC, S100B, FGFR1, NES, NTRK2, IDH1
41cysteine448.0FGFR1, TNC, THBS1, GFAP, RAF1, PDGFRB
42paraffin447.6THBS1, GFAP, TNC, APOD, BRAF, NES
43progesterone44 28 60 24 1111.6PDGFRB, FGFR1, S100B, SYP, THBS1, GFAP
44serine447.6GFAP, TNC, DCX, BRAF, LGALS3, NTRK2
45calcium44 50 24 1110.4THBS1, TIMP3, DCX, BRAF, LGALS3, NTRK2
46tyrosine447.3BRAF, S100B, TIMP3, NES, NTRK2, SYP
47lipid447.3TNC, FGFR1, KRAS, S100B, PDGFRB, APOD
48retinoic acid44 248.1THBS1, GFAP, TNC, APOD, TIMP3, BRAF
49estrogen447.1APOD, TNC, GFAP, THBS1, TIMP3, BRAF
50vegf447.1FGFR1, KRAS, S100B, RAF1, PDGFRB, SYP

GO Terms for genes affiliated with Pilocytic Astrocytoma

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Cellular components related to Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1presynaptic active zoneGO:004878610.0SYP, NTRK2
2extracellular matrixGO:00310129.1LGALS3, TIMP3, TNC, THBS1
3cytosolGO:00058298.5IDH1, GFAP, DCX, BRAF, SRGAP3, NTRK2

Biological processes related to Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1peripheral nervous system axon regenerationGO:001401210.3APOD, TNC
2activation of MAPKK activityGO:000018610.3BRAF, RAF1, KRAS
3positive regulation of phospholipase C activityGO:001086310.2FGFR1, PDGFRB
4MAPK cascadeGO:000016510.2FGFR1, KRAS, RAF1
5positive regulation of MAP kinase activityGO:004340610.2KRAS, PDGFRB, FGFR1
6positive regulation of phosphatidylinositol 3-kinase signalingGO:001406810.1NTRK2, FGFR1, PDGFRB
7positive regulation of gene expressionGO:001062810.1TNC, BRAF, NTRK2, KRAS
8negative regulation of neuron apoptotic processGO:004352410.1BRAF, NES, NTRK2, KRAS
9negative regulation of focal adhesion assemblyGO:005189510.1APOD, THBS1
10oligodendrocyte differentiationGO:004870910.1SOX10, NTRK2
11wound healingGO:004206010.1RAF1, TNC, PDGFRB
12long-term synaptic potentiationGO:006029110.0GFAP, NTRK2, S100B
13positive regulation of calcium ion importGO:009028010.0LGALS3, PDGFRB
14Fc-epsilon receptor signaling pathwayGO:003809510.0PDGFRB, RAF1, KRAS, FGFR1
15epidermal growth factor receptor signaling pathwayGO:000717310.0RAF1, PDGFRB, KRAS, FGFR1
16neuron migrationGO:000176410.0DCX, NTRK2, FGFR1
17small GTPase mediated signal transductionGO:00072649.9BRAF, SRGAP3, RAF1, KRAS
18positive regulation of chemotaxisGO:00509219.9PDGFRB, THBS1
19fibroblast growth factor receptor signaling pathwayGO:00085439.9BRAF, RAF1, PDGFRB, KRAS, FGFR1
20axon guidanceGO:00074119.8FGFR1, KRAS, RAF1, DCX
21regulation of neuronal synaptic plasticityGO:00481689.7S100B, SYP
22neurotrophin TRK receptor signaling pathwayGO:00480119.7PDGFRB, FGFR1, KRAS, RAF1, NTRK2, BRAF
23central nervous system developmentGO:00074179.6NES, DCX, S100B
24negative regulation of apoptotic processGO:00430669.5PDGFRB, BRAF, SOX10, THBS1, RAF1
25extracellular matrix organizationGO:00301989.5THBS1, LGALS3, TNC, GFAP
26positive regulation of cell proliferationGO:00082849.4TNC, PDGFRB, S100B, KRAS, NTRK2, FGFR1
27innate immune responseGO:00450879.3RAF1, LGALS3, KRAS, PDGFRB, FGFR1, S100B
28cell migrationGO:00164779.3FGFR1, PDGFRB, THBS1

Molecular functions related to Pilocytic Astrocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mitogen-activated protein kinase kinase bindingGO:003143410.1RAF1, BRAF
2small GTPase bindingGO:00312679.8RAF1, BRAF
3identical protein bindingGO:00428028.7FGFR1, THBS1, SOX10, BRAF, SYP, RAF1
4protein bindingGO:00055157.3THBS1, APOD, TIMP3, SOX10, BRAF, SRGAP3

Sources for Pilocytic Astrocytoma

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
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27ICD9CM
28IUPHAR
29KEGG
33MeSH
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35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
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46OMIM
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61UMLS
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