MCID: PLM021
MIFTS: 35

Pilomyxoid Astrocytoma malady

Categories: Neuronal diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Pilomyxoid Astrocytoma

Aliases & Descriptions for Pilomyxoid Astrocytoma:

Name: Pilomyxoid Astrocytoma 12 56 14 69

Characteristics:

Orphanet epidemiological data:

56
pilomyxoid astrocytoma
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:4845
NCIt 47 C40315
SNOMED-CT 64 388600004
Orphanet 56 ORPHA251615
UMLS via Orphanet 70 C1519086
ICD10 via Orphanet 34 C71.9
UMLS 69 C1519086

Summaries for Pilomyxoid Astrocytoma

MalaCards based summary : Pilomyxoid Astrocytoma is related to pilocytic astrocytoma and astrocytoma. An important gene associated with Pilomyxoid Astrocytoma is SYP (Synaptophysin), and among its related pathways/superpathways are Spinal Cord Injury and Neural Crest Differentiation. The drugs Histamine and Cyproheptadine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and cerebellum, and related phenotype is normal.

Related Diseases for Pilomyxoid Astrocytoma

Diseases related to Pilomyxoid Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
id Related Disease Score Top Affiliating Genes
1 pilocytic astrocytoma 32.4 GFAP SYP
2 astrocytoma 10.8
3 diabetes hypogonadism deafness mental retardation 10.2 GFAP SYP
4 papillary tumor of the pineal region 10.2 GFAP SYP
5 brain stem ependymoma 10.2 GFAP SYP
6 intrahepatic bile duct adenoma 10.2 GFAP SYP
7 children's interstitial lung disease 10.2 GFAP SYP
8 cervical benign neoplasm 10.2 GFAP SYP
9 myxopapillary ependymoma 10.2 GFAP SYP
10 epidermal appendage tumor 10.2 GFAP SYP
11 microinvasive cervical squamous cell carcinoma 10.2 GFAP SYP
12 clear cell meningioma 10.2 GFAP SYP
13 nephrogenic adenoma of urinary bladder 10.2 GFAP SYP
14 paternal uniparental disomy of chromosome 1 10.2 GFAP SYP
15 cerebral folate receptor alpha deficiency 10.2 GFAP SYP
16 vulvar benign neoplasm 10.2 GFAP SYP
17 adenofibroma 10.2 GFAP SYP
18 behcet's syndrome arthropathy 10.2 GFAP SYP
19 blood group incompatibility 10.2 GFAP SYP
20 aneurysm of sinus of valsalva 10.2 GFAP SYP
21 male reproductive system disease 10.2 GFAP SYP
22 pleomorphic xanthoastrocytoma 10.2 GFAP SYP
23 mediastinal granular cell myoblastoma 10.2 GFAP SYP
24 central neurocytoma 10.2 GFAP SYP
25 mast-cell sarcoma 10.2 GFAP SYP
26 olfactory neuroblastoma 10.2 GFAP SYP
27 hypogonadotropic hypogonadism-retinitis pigmentosa syndrome 10.2 GFAP SYP
28 superior vena cava syndrome 10.1 GFAP SYP
29 pineoblastoma 10.1 GFAP SYP
30 piussan lenaerts mathieu syndrome 10.1 GFAP SYP
31 pneumothorax 10.1 GFAP SYP
32 brain stem astrocytic neoplasm 10.1 GFAP SYP
33 calcific tendinitis 10.1 GFAP SYP
34 auricular cancer 10.1 GFAP SYP
35 dysgerminoma of ovary 10.1 GFAP SYP
36 pediculus humanus corporis infestation 10.1 GFAP SYP
37 brain oligodendroglioma 10.1 GFAP SYP
38 arthus reaction 10.1 GFAP SYP
39 childhood central nervous system primitive neuroectodermal neoplasm 10.1 GFAP SYP
40 bone dysplasia azouz type 10.1 GFAP SYP
41 pancreatic cancer 10.1 GFAP SYP
42 pacinian tumor 10.1 GFAP SYP
43 temporal lobe neoplasm 10.1 GFAP SYP
44 melanotic neurilemmoma 10.1 GFAP SYP
45 clear cell variant infiltrating bladder urothelial carcinoma 10.1 GFAP SYP
46 myoepithelial carcinoma 10.1 GFAP SYP
47 inner ear cancer 10.1 GFAP SYP
48 pharynx cancer 10.1 GFAP SYP
49 focal cortical dysplasia, taylor balloon cell type 10.1 GFAP SYP
50 childhood medulloblastoma 10.1 GFAP SYP

Graphical network of the top 20 diseases related to Pilomyxoid Astrocytoma:



Diseases related to Pilomyxoid Astrocytoma

Symptoms & Phenotypes for Pilomyxoid Astrocytoma

MGI Mouse Phenotypes related to Pilomyxoid Astrocytoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 8.92 COL1A1 COL2A1 GFAP SYP

Drugs & Therapeutics for Pilomyxoid Astrocytoma

Drugs for Pilomyxoid Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 58)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
2
Cyproheptadine Approved Phase 3 129-03-3 2913
3 Dermatologic Agents Phase 3,Phase 1
4
Histamine Phosphate Phase 3 51-74-1 65513
5
Serotonin Phase 3 50-67-9 5202
6 Serotonin Agents Phase 3
7 Serotonin Antagonists Phase 3
8 Gastrointestinal Agents Phase 3
9 Neurotransmitter Agents Phase 3
10 Histamine Antagonists Phase 3
11 Histamine H1 Antagonists Phase 3
12 Anti-Allergic Agents Phase 3
13 Antipruritics Phase 3
14
Vincristine Approved, Investigational Phase 1, Phase 2 2068-78-2, 57-22-7 5978
15
Irinotecan Approved, Investigational Phase 1, Phase 2 97682-44-5, 100286-90-6 60838
16
Carboplatin Approved Phase 1, Phase 2 41575-94-4 10339178 498142 38904
17
Cetuximab Approved Phase 1, Phase 2 205923-56-4 56842117 2333
18
Dacarbazine Approved, Investigational Phase 1, Phase 2 4342-03-4 5351166
19
Temozolomide Approved, Investigational Phase 1, Phase 2 85622-93-1 5394
20
Piperazine Approved, Vet_approved Phase 1, Phase 2 110-85-0 4837
21
Mebendazole Approved, Vet_approved Phase 1, Phase 2 31431-39-7 4030
22
Bevacizumab Approved, Investigational Phase 1, Phase 2 216974-75-3
23
Crizotinib Approved Phase 1, Phase 2 877399-52-5 11626560 10366136 10366137 10366138 10366139 10366140 10366141
24 Alkylating Agents Phase 1, Phase 2
25 topoisomerase I inhibitors Phase 1, Phase 2
26 Topoisomerase Inhibitors Phase 1, Phase 2
27 Angiogenesis Inhibitors Phase 1, Phase 2
28 Angiogenesis Modulating Agents Phase 1, Phase 2
29 Anthelmintics Phase 1, Phase 2
30 Piperazine citrate Phase 1, Phase 2
31 Anti-Infective Agents Phase 1, Phase 2
32 Anticonvulsants Phase 1, Phase 2
33 Antimitotic Agents Phase 1, Phase 2
34 Antineoplastic Agents, Alkylating Phase 1, Phase 2
35 Antineoplastic Agents, Phytogenic Phase 1, Phase 2
36 Antiparasitic Agents Phase 1, Phase 2
37 Protein Kinase Inhibitors Phase 1, Phase 2
38 Citrate Nutraceutical Phase 1, Phase 2
39
Citric Acid Nutraceutical, Vet_approved Phase 1, Phase 2 77-92-9 311
40
Verteporfin Approved, Investigational Phase 1 129497-78-5
41
Trioxsalen Approved Phase 1 3902-71-4 5585
42
Niacin Approved, Investigational, Nutraceutical Phase 1 59-67-6 938
43
Nicotinamide Approved, Nutraceutical Phase 1 98-92-0 936
44
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
45 Dihematoporphyrin Ether Phase 1
46 Photosensitizing Agents Phase 1
47 Nicotinic Acids Phase 1
48 Trace Elements Phase 1
49 Vitamin B Complex Phase 1
50 Vitamins Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3
2 A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas Recruiting NCT01837862 Phase 1, Phase 2
3 Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22 Recruiting NCT01884740 Phase 1, Phase 2
4 Crizotinib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma Active, not recruiting NCT00939770 Phase 1, Phase 2
5 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1
6 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1
7 18F-FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly-Diagnosed or Recurrent Gliomas Terminated NCT02175745
8 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452

Search NIH Clinical Center for Pilomyxoid Astrocytoma

Genetic Tests for Pilomyxoid Astrocytoma

Anatomical Context for Pilomyxoid Astrocytoma

MalaCards organs/tissues related to Pilomyxoid Astrocytoma:

39
Spinal Cord, Brain, Cerebellum, Pineal, Hypothalamus

Publications for Pilomyxoid Astrocytoma

Articles related to Pilomyxoid Astrocytoma:

(show top 50) (show all 67)
id Title Authors Year
1
Parietal pilomyxoid astrocytoma with recurrence in 10 months: A case report and review of literature. ( 27366287 )
2016
2
Cytopathological features of pilomyxoid astrocytoma: a case report. ( 27018339 )
2016
3
SOX10 Distinguishes Pilocytic and Pilomyxoid Astrocytomas From Ependymomas but Shows No Differences in Expression Level in Ependymomas From Infants Versus Older Children or Among Molecular Subgroups. ( 26945037 )
2016
4
Spontaneous intratumoural and intraventricular haemorrhage associated with a pilomyxoid astrocytoma in the hypothalamic/chiasmatic region. ( 27450285 )
2016
5
Pilomyxoid astrocytoma involving the entire spinal cord in a newborn. ( 27106533 )
2016
6
Single-Agent Carboplatin for a Rare Case of Pilomyxoid Astrocytoma of the Spinal Cord in an Adult with Neurofibromatosis Type 1. ( 27920686 )
2016
7
Disseminated pilomyxoid astrocytoma in infancy with novel MUTYH mutation. ( 27797849 )
2016
8
Pilomyxoid astrocytoma in the adult cerebellum. ( 26777083 )
2016
9
Cystic pilomyxoid astrocytoma on suprasellar region in 7-year-old girl: Treatment and strategy. ( 25972955 )
2015
10
Optic nerve pilomyxoid astrocytoma in a patient with Noonan syndrome. ( 25585602 )
2015
11
Pilomyxoid astrocytoma in an adult woman: Case report. ( 26458706 )
2015
12
Pilomyxoid Astrocytoma Occurring in the Third Ventricle. ( 26312139 )
2015
13
Pilomyxoid Astrocytoma (PMA) Shows Significant Differences in Gene Expression vs. Pilocytic Astrocytoma (PA) and Variable Tendency Toward Maturation to PA. ( 25521223 )
2014
14
Pilomyxoid astrocytoma of the pineal region: Cytopathological features and differential diagnostic considerations by intraoperative smear preparation. ( 24578310 )
2014
15
Pilomyxoid astrocytoma in an elderly patient: A case report and review of literature. ( 25387630 )
2014
16
Pilomyxoid astrocytoma treated successfully with vemurafenib. ( 24821190 )
2014
17
Pilomyxoid astrocytoma of the cerebellar vermis in an elderly patient. ( 24778917 )
2014
18
Pilomyxoid astrocytoma presenting as diencephalic syndrome. ( 25672198 )
2014
19
Sustained response to weekly vinblastine in 2 children with pilomyxoid astrocytoma associated with diencephalic syndrome. ( 23042016 )
2013
20
Pilomyxoid astrocytoma. ( 23495811 )
2013
21
Response. Pilomyxoid astrocytoma. ( 23767070 )
2013
22
Pilomyxoid astrocytoma with high proliferation index. ( 24470824 )
2013
23
Pilomyxoid astrocytoma of the cerebellum with Williams syndrome: a case report. ( 23604363 )
2013
24
Primary pilomyxoid astrocytoma of the thoracolumbar spinal cord in an adult. ( 24441351 )
2013
25
Occurrence and distribution of pilomyxoid astrocytoma. ( 23281683 )
2013
26
Pediatric spinal pilomyxoid astrocytoma. ( 24053650 )
2013
27
Response. Pilomyxoid astrocytoma. ( 23767069 )
2013
28
Significance of radical resection for pilomyxoid astrocytoma of the cerebellum: a case report and review of the literature. ( 23503634 )
2013
29
Insulin-like growth factor 2 mRNA binding protein 3 expression is an independent prognostic factor in pediatric pilocytic and pilomyxoid astrocytoma. ( 23584203 )
2013
30
Pilomyxoid astrocytoma of the brainstem. ( 23888217 )
2013
31
T2 and DWI in pilocytic and pilomyxoid astrocytoma with pathologic correlation. ( 22728857 )
2012
32
Intramedullary pilomyxoid astrocytoma with intracerebral metastasis exhibiting oligoden-droglioma-like features. ( 22826787 )
2012
33
Intermediate pilomyxoid astrocytoma and diencephalic syndrome: imaging findings. ( 23052462 )
2012
34
Temporal and optic pathway pilomyxoid astrocytoma mimicking dural-based lesion: case report and review of the literature. ( 23548417 )
2012
35
Successful treatment of leptomeningeal gliomatosis of pilomyxoid astrocytoma after failed frontline chemotherapy. ( 22217612 )
2012
36
Diencephalic juvenile pilomyxoid astrocytoma with leptomeningeal dissemination. ( 21534206 )
2011
37
Pilomyxoid astrocytoma of the cerebellum. ( 21529196 )
2011
38
Pilomyxoid astrocytoma in cerebellum. ( 23467810 )
2011
39
Pilomyxoid astrocytoma of the cervical spinal cord in a child with rapid progression into glioblastoma: case report and literature review. ( 20461521 )
2011
40
Pilomyxoid astrocytoma. ( 20551536 )
2010
41
Pilomyxoid astrocytoma in unusual location in a child with neurofibromatosis type 1: case report and review of the literature. ( 20496528 )
2010
42
Pilomyxoid astrocytoma of the cervical spinal cord successfully treated with chemotherapy: case report. ( 21030812 )
2010
43
Juvenile pilomyxoid astrocytoma in the opticohypothalamus. ( 21286484 )
2010
44
A case of pilomyxoid astrocytoma presenting with CSF rhinorrhoea in a 15-year-old. ( 19718549 )
2009
45
Pilomyxoid astrocytoma with involvement of the sella turcica in an adolescent. ( 19766001 )
2009
46
Hemorrhagic onset of pilocytic astrocytoma and pilomyxoid astrocytoma. ( 19408090 )
2009
47
Clinicopathological features and global genomic copy number alterations of pilomyxoid astrocytoma in the hypothalamus/optic pathway: comparative analysis with pilocytic astrocytoma using array-based comparative genomic hybridization. ( 18622384 )
2008
48
Magnetic resonance imaging characteristics of pilomyxoid astrocytoma. ( 18662499 )
2008
49
Pilomyxoid astrocytoma of the spinal cord with cerebrospinal fluid and peritoneal metastasis. ( 19165714 )
2008
50
Pilomyxoid astrocytoma in a patient presenting with fatal hemorrhage. Case report. ( 18352771 )
2008

Variations for Pilomyxoid Astrocytoma

Copy number variations for Pilomyxoid Astrocytoma from CNVD:

7 (show all 14)
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 38162 10 1 3000000 Gain DIP2C Pilomyxoid astrocytoma
2 97080 15 98500000 102531392 Loss LASS3 Pilomyxoid astrocytoma
3 121279 18 41800000 46400000 Microdeletion TCF4 Pilomyxoid astrocytoma
4 234564 8 136400000 146364022 Gain COL22A1 Pilomyxoid astrocytoma
5 234874 8 139900000 146364022 Gain CYHR1 Pilomyxoid astrocytoma
6 234879 8 139900000 146364022 Gain FOXH1 Pilomyxoid astrocytoma
7 234882 8 139900000 146364022 Gain GPT Pilomyxoid astrocytoma
8 234885 8 139900000 146364022 Gain KIFC2 Pilomyxoid astrocytoma
9 234887 8 139900000 146364022 Gain LRRC14 Pilomyxoid astrocytoma
10 234889 8 139900000 146364022 Gain LRRC24 Pilomyxoid astrocytoma
11 234891 8 139900000 146364022 Gain MFSD3 Pilomyxoid astrocytoma
12 234894 8 139900000 146364022 Gain PPP1R16A Pilomyxoid astrocytoma
13 234898 8 139900000 146364022 Gain RECQL4 Pilomyxoid astrocytoma
14 244901 9 1 2200000 Loss ANKRD15 Pilomyxoid astrocytoma

Expression for Pilomyxoid Astrocytoma

Search GEO for disease gene expression data for Pilomyxoid Astrocytoma.

Pathways for Pilomyxoid Astrocytoma

Pathways related to Pilomyxoid Astrocytoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.34 COL2A1 GFAP
2 11.16 COL2A1 GFAP
3 10.86 GFAP SYP
4 10.41 COL1A1 COL2A1

GO Terms for Pilomyxoid Astrocytoma

Cellular components related to Pilomyxoid Astrocytoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 collagen trimer GO:0005581 8.62 COL1A1 COL2A1

Biological processes related to Pilomyxoid Astrocytoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sensory perception of sound GO:0007605 9.4 COL1A1 COL2A1
2 ossification GO:0001503 9.37 COL1A1 COL2A1
3 collagen catabolic process GO:0030574 9.32 COL1A1 COL2A1
4 skeletal system morphogenesis GO:0048705 9.26 COL1A1 COL2A1
5 collagen fibril organization GO:0030199 9.16 COL1A1 COL2A1
6 endochondral ossification GO:0001958 8.96 COL1A1 COL2A1
7 cartilage development involved in endochondral bone morphogenesis GO:0060351 8.62 COL1A1 COL2A1

Molecular functions related to Pilomyxoid Astrocytoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.26 COL1A1 COL2A1 GFAP SYP
2 extracellular matrix structural constituent GO:0005201 9.16 COL1A1 COL2A1
3 platelet-derived growth factor binding GO:0048407 8.62 COL1A1 COL2A1

Sources for Pilomyxoid Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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