MCID: PNB001
MIFTS: 32

Pineoblastoma malady

Neuronal, Cancer categories

Summaries for Pineoblastoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Pineoblastoma is a cancerous (malignant) tumor that develops in the pineal gland.  the pineal gland is located in the brain and makes the hormone melatonin to regulate the body's sleep patterns.  pineoblastoma is a type of primitive neuroectodermal tumor (pnet).  pineoblastoma mainly affects children, but can also occur in adults.  treatment of pineoblastoma includes surgery to remove as much of the tumor as possible, followed by radiation therapy and chemotherapy. last updated: 12/15/2011

MalaCards: Pineoblastoma, also known as pineal pnet, is related to pineocytoma and medulloepithelioma. An important gene associated with Pineoblastoma is ASMT (acetylserotonin O-methyltransferase). The compounds n-acetylaspartate and s 100 have been mentioned in the context of this disorder. Affiliated tissues include the brain.

Disease Ontology:8 A pineal gland neoplasm located in the brain.

Wikipedia:64 Pinealoblastoma is a tumor of the pineal gland. more...

Aliases & Classifications for Pineoblastoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 40NCIt, 35MeSH, 57SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Neuronal


Aliases & Descriptions:

pineoblastoma 8 43 10 45 49 61
pineal pnet 8


External Ids:

Disease Ontology8 DOID:1664
NCIt40 C9344
SNOMED-CT57 31671006
MeSH35 D010871

Related Diseases for Pineoblastoma

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Pineoblastoma family:

adult pineoblastoma

Diseases related to Pineoblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1pineocytoma30.3GFAP, SAG, SYP, ASMT
2medulloepithelioma29.9SYP
3adenoma29.9SAG, TP53, SYP, CGA
4pineoblastoma, childhood10.4
5adult pineoblastoma10.4
6trilateral retinoblastoma10.1
7pineal cyst10.1
8dysembryoplastic neuroepithelial tumor10.0SYP
9ganglioneuroblastoma10.0SYP
10giant cell glioblastoma10.0GFAP
11melanotic neuroectodermal tumor10.0SYP
12rhabdoid tumor10.0SYP
13gemistocytic astrocytoma10.0GFAP
14gliomatosis cerebri10.0GFAP
15myoepithelioma10.0GFAP
16subependymal giant cell astrocytoma10.0GFAP, SYP
17binswanger's disease10.0GFAP, SYP
18papillary ependymoma10.0SYP, GFAP
19leydig cell tumor10.0CGA
20ganglioglioma10.0SYP, GFAP
21hemangioblastoma10.0GFAP, SYP
22central neurocytoma10.0SYP, GFAP
23pilocytic astrocytoma10.0SYP, GFAP
24anaplastic oligodendroglioma10.0GFAP
25ependymoma10.0SYP, GFAP
26teratocarcinoma10.0POU5F1, SYP
27placental site trophoblastic tumor10.0LNPEP, CGA
28trophoblastic neoplasm10.0CGA, LNPEP
29teratoma10.0GFAP, CGA, POU5F1
30choriocarcinoma10.0LNPEP, CGA
31choroid plexus papilloma10.0GFAP, TP53
32neuroblastoma10.0SYP, TP53
33brain cancer10.0GFAP, TP53, SYP
34pituitary adenoma10.0SYP, POU5F1, CGA
35seminoma10.0LNPEP, POU5F1, CGA
36germinoma10.0POU5F1, CGA
37tuberous sclerosis10.0SYP, GFAP
38medulloblastoma10.0TP53, GFAP, SYP, SAG
39oligodendroglioma10.0TP53, SYP, GFAP
40gestational trophoblastic neoplasm10.0LNPEP, CGA
41chordoid glioma10.0RGS16, ZFHX4, RFX3
42bilateral retinoblastoma10.0
43unilateral retinoblastoma10.0
44familial adenomatous polyposis10.0
45supratentorial primitive neuroectodermal tumor10.0
46aspergillosis10.0
47astrocytoma10.0
48turcot syndrome10.0
49retinoblastoma10.0TP53, SYP, GFAP, ASMT, SAG
50childhood medulloblastoma10.0FAM129A, CADPS, OR4C12

Graphical network of the top 20 diseases related to Pineoblastoma:



Diseases related to pineoblastoma

Clinical Features for Pineoblastoma

Drugs & Therapeutics for Pineoblastoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Pineoblastoma

Drug clinical trials:

Search ClinicalTrials for Pineoblastoma

Search NIH Clinical Center for Pineoblastoma

Search CenterWatch for Pineoblastoma

Genetic Tests for Pineoblastoma

Anatomical Context for Pineoblastoma

Sources:
14FMA
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FMA organs/tissues related to Pineoblastoma:

14
The brain

Animal Models for Pineoblastoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Pineoblastoma

Sources:
51PubMed
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Articles related to Pineoblastoma:

(show top 50)    (show all 63)
idTitleAuthorsYear
1
Incidence of pineal gland cyst and pineoblastoma in children with retinoblastoma during the chemoreduction era. (23876864)
2013
2
Incidence of pineal gland cyst and pineoblastoma in children with retinoblastoma during the chemoreduction era. (24238207)
2013
3
Germline DICER1 mutation and associated loss of heterozygosity in a pineoblastoma. (22717647)
2012
4
The long-term postsurgical prognosis of patients with pineoblastoma. (21717450)
2012
5
Contemporary management of pineoblastoma. (21801990)
2011
6
Genome-wide molecular characterization of central nervous system primitive neuroectodermal tumor and pineoblastoma. (21798848)
2011
7
Post-chemotherapy maturation of a pineoblastoma. (20224924)
2010
8
Severe cytomegalic pneumonitis associated with pulmonary aspergillosis in a child with immunosuppression due to chemotherapy for treating pineoblastoma. (19287944)
2009
9
Response of an adult patient with pineoblastoma to vorinostat and retinoic acid. (19506816)
2009
10
Post-radiation reactive changes in a single vertebral body mimicking metastatic pineoblastoma. (19877784)
2009
11
Transformation of a low-grade pineal parenchymal tumour to secondary pineoblastoma. (19284482)
2009
12
Outcome of pediatric pineoblastoma after surgery, radiation and chemotherapy. (18415046)
2008
13
Diffusion-weighted MR images and pineoblastoma: diagnosis and follow-up. (18392417)
2008
14
Congenital pineoblastoma and parameningeal rhabdomyosarcoma: concurrent two embryonal tumors in a young infant. (16283194)
2006
15
Cytogenetics of pineoblastoma: four new cases and a literature review. (17011992)
2006
16
Molecular genetics of supratentorial primitive neuroectodermal tumors and pineoblastoma. (16398467)
2005
17
Management and survival of pineoblastoma: an analysis of 34 adults from the brain tumor registry of Japan. (15782004)
2005
18
Pathologic quiz case: a 15-year-old girl with an intracranial midline mass. Pineoblastoma, World Health Organization Grade IV. (15163221)
2004
19
Surgical treatment of a mixed pineocytoma/pineoblastoma in a 72-year-old patient. (12021888)
2002
20
Detection of a pineoblastoma with large central cyst in a young child. (11981625)
2002
21
Screening for pineoblastoma in patients with retinoblastoma. (12470168)
2002
22
Vertebral metastases from pineoblastoma. (11419982)
2001
23
Long-term survival following extra-neural metastasis from a pineoblastoma. (11083078)
2000
24
Non-resective management of pineoblastoma. (11108118)
2000
25
F-18 FDG PET scan of a metastatic pineoblastoma. (10069738)
1999
26
Pineoblastoma showing unusual ventricular extension in a young adult--case report. (10487041)
1999
27
A new pineoblastoma cell line, PER-480, with der(10)t(10;17), der(16)t(1;16), and enhanced MYC expression in the absence of gene amplification. (9428362)
1998
28
Pineoblastoma presenting in familial adenomatous polyposis (FAP): random association, FAP variant or Turcot syndrome? (10070471)
1998
29
Astrocytoma and pineoblastoma arising sequentially in the fourth ventricle of the same patient. Case report and molecular analysis. (9361116)
1997
30
Treatment of patients with pineoblastoma with high dose cyclophosphamide. (8614374)
1996
31
Lack of efficacy of postoperative chemotherapy and delayed radiation in very young children with pineoblastoma. Pediatric Oncology Group. (7753001)
1995
32
Enhanced MYCN expression and isochromosome 17q in pineoblastoma cell lines. (7513543)
1994
33
Peritoneal metastases in two patients with pineoblastoma and ventriculo-peritoneal shunts. (8152405)
1994
34
Response to neoadjuvant chemotherapy in children with pineoblastoma. (8348511)
1993
35
Metastatic pineoblastoma via a ventriculoperitoneal shunt: CT demonstration. (1394082)
1992
36
Concurrent benign teratoid medulloepithelioma and pineoblastoma. (1513537)
1992
37
Implantation metastasis of pineoblastoma after stereotactic biopsy. Case report. (2195142)
1990
38
Phase II treatment of medulloblastoma and pineoblastoma with melphalan: clinical therapy based on experimental models of human medulloblastoma. (2738624)
1989
39
Pineoblastoma in a cockatiel. (3196277)
1988
40
Pineoblastoma with neuronal differentiation--immunohistochemical and immunocytochemical studies. (3066852)
1988
41
Pineoblastoma with an unusually long survival. Case report. (3392573)
1988
42
Computed tomography of familial pineoblastoma. (3944313)
1986
43
Familial pineoblastoma. Report of two cases. (3998847)
1985
44
Congenital pineoblastoma in the newborn: ultrasound evaluation. (3880907)
1985
45
Trilateral retinoblastoma. Pineoblastoma (ectopic intracranial retinoblastoma) associated with bilateral retinoblastoma. (6544387)
1984
46
Pineoblastoma, a primitive neuroectodermal tumor in the brain of a horse. (7147618)
1982
47
Pineoblastoma with ganglionic and glial differentiation: report of two cases. (7349581)
1981
48
The separation of pineocytoma from pineoblastoma. (6986979)
1980
49
Pineoblastoma: an electron microscopic study. (498040)
1979
50
Pineoblastoma with spontaneous intra and extracranial metastasis. (4548088)
1974

Genetic Variations for Pineoblastoma

Expression for genes affiliated with Pineoblastoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pineoblastoma

Search GEO for disease gene expression data for Pineoblastoma.

Pathways for genes affiliated with Pineoblastoma

Compounds for genes affiliated with Pineoblastoma

Sources:
45Novoseek, 50PharmGKB, 60Tocris Bioscience, 11DrugBank, 24HMDB, 29IUPHAR
See all sources

Compounds related to Pineoblastoma according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1n-acetylaspartate4510.2GFAP, SYP
2s 1004510.2GFAP, SYP
3reticulin4510.0GFAP, SYP
48-bromo-cyclic amp4510.0CGA, GFAP
5dutp459.9TP53, GFAP, SYP
6letrozole45 50 60 1112.9SYP, CGA
7dbc-amp459.7ASMT, GFAP, SYP, CGA
8carboplatin45 50 1111.5TP53, LNPEP, CGA
9cyclic amp45 2410.5SAG, CGA, SYP, GFAP, ASMT
105-hydroxytryptamine459.4ASMT, GFAP, RGS16, SYP, SAG
11paraffin459.4SAG, CGA, SYP, GFAP, TP53
12norepinephrine45 11 2411.3CADPS, CGA, SYP, POU5F1
13vegf459.2TP53, GFAP, POU5F1, SYP, CGA
14forskolin45 50 1111.1GFAP, LNPEP, SYP, CGA
15cisplatin45 50 60 1112.1CGA, SYP, LNPEP, GFAP, TP53
16progesterone45 60 29 11 2413.0CGA, SYP, LNPEP, GFAP, TP53
17dopamine45 29 11 2412.0CADPS, SAG, CGA, SYP, POU5F1, GFAP
18leucine458.9GFAP, LNPEP, SYP, SAG
19alanine458.6SAG, CGA, LNPEP, RGS16, GFAP

GO Terms for genes affiliated with Pineoblastoma

Sources:
16Gene Ontology
See all sources

Molecular functions related to Pineoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription regulatory region DNA bindingGO:0442129.1RFX3, TP53, POU5F1

Products for genes affiliated with Pineoblastoma

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  • Lysates
  • Antibodies

Sources for Pineoblastoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet