Pineoblastoma malady

NIH Rare Diseases: Pineoblastoma is a cancerous (malignant) tumor that develops in the pineal gland.  The pineal gland is located in the brain and makes the hormone melatonin to regulate the body's sleep patterns.  Pineoblastoma is a type of primitive neuroectodermal tumor (PNET).  Pineoblastoma mainly affects children, but can also occur in adults.  Treatment of pineoblastoma includes surgery to remove as much of the tumor as possible, followed by radiation therapy and chemotherapy.³⁰

MalaCards: Pineoblastoma, also known as pineoblastoma (morphologic abnormality), is related to neuroectodermal tumors and papillary ependymoma. An important gene associated with Pineoblastoma is ASMT (acetylserotonin O-methyltransferase). The compounds n-acetylaspartate and s 100 have been mentioned in the context of this disorder. Affiliated tissues include the brain, brain and pineal.

Disease Ontology: A pineal gland neoplasm located in the brain.⁶

Wikipedia: Pinealoblastoma is a tumor of the pineal gland.⁴⁴ more...

Aliases & Descriptions:

pineoblastoma 6 30 8 32 43 pineoblastoma (morphologic abnormality) 6

pineal pnet 6

Diseases related to pineoblastoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 77)

id	Related Disease	Score	Top Affiliating Genes
1	neuroectodermal tumors	26.9	SYP, GFAP, TP53, CADPS
2	papillary ependymoma	13.4	GFAP, SYP
3	pilomyxoid astrocytoma	13.4	SYP, GFAP
4	central neurocytoma	13.4	SYP, GFAP
5	cerebellar medulloblastoma	13.3	GFAP, SAG
6	binswanger's disease	13.3	SYP, GFAP
7	hereditary cerebral hemorrhage with amyloidosis	13.3	SYP, GFAP
8	mesenchymal cell neoplasm	13.3	SYP, GFAP
9	large cell medulloblastoma	13.2	SYP, SAG
10	yaws	13.2	RGS16, POU5F1
11	pineal gland cancer	13.2	SYP, GFAP, ASMT
12	neuroendocrine carcinoma of the cervix	13.2	TP53, SYP
13	cerebrum cancer	13.1	TP53, GFAP
14	ewing's family of tumors	13.1	SYP, GFAP
15	choroid plexus carcinoma	13.1	SYP, TP53
16	pulmonary blastoma	13.1	SYP, TP53
17	gemistocytic astrocytoma	13.1	GFAP, TP53
18	oligoastrocytoma	13.0	GFAP, TP53
19	placental site trophoblastic tumor	13.0	CGA, LNPEP
20	gliomatosis cerebri	13.0	GFAP, TP53
21	mixed cell type cancer	13.0	GFAP, TP53
22	trophoblastic neoplasm	13.0	LNPEP, CGA
23	granulosa cell tumor of the ovary	13.0	SYP, TP53
24	epithelioid trophoblastic tumor	13.0	LNPEP, CGA
25	pineocytoma	12.9	SYP, GFAP, ASMT, SAG
26	sacrococcygeal teratoma	12.9	CGA, GFAP, POU5F1
27	cerebellar liponeurocytoma	12.9	SYP, GFAP, TP53
28	giant cell glioblastoma	12.9	TP53, GFAP, SYP
29	choroid plexus papilloma	12.9	GFAP, TP53
30	pleomorphic xanthoastrocytoma	12.9	SYP, GFAP, TP53
31	subependymal giant cell astrocytoma	12.9	TP53, GFAP, SYP
32	atypical teratoid rhabdoid tumor	12.9	SYP, GFAP, TP53
33	dysembryoplastic neuroepithelial tumor	12.9	SYP, GFAP, TP53
34	supratentorial primitive neuroectodermal tumor	12.9	TP53, GFAP, SYP
35	triploidy	12.9	CGA, TP53
36	ganglioneuroblastoma	12.9	TP53, GFAP, SYP
37	diffuse astrocytoma	12.9	TP53, GFAP, SYP
38	blastoma	12.9	SYP, GFAP, TP53
39	ganglioglioma	12.9	TP53, GFAP, SYP
40	hemangioblastoma	12.8	SYP, GFAP, TP53
41	head injury	12.8	TP53, GFAP, SYP
42	gliosis	12.8	TP53, GFAP, SYP
43	rhabdoid tumors	12.8	TP53, GFAP, SYP
44	pilocytic astrocytoma	12.8	SYP, GFAP, TP53
45	malignant fibrous histiocytoma	12.7	TP53, GFAP, SYP
46	serous cystadenoma	12.7	TP53, SYP
47	myoepithelioma	12.7	GFAP, TP53
48	ependymoma	12.7	TP53, GFAP, SYP
49	large cell carcinoma	12.6	SYP, TP53, CGA
50	germ cell cancer	12.6	CGA, TP53, SYP

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to pineoblastoma:

²²

FMA organs/tissues related to pineoblastoma:

¹¹

Articles related to pineoblastoma:

id	Title	Authors	Year	Affiliating Genes
1	Genome-wide molecular characterization of central ner vous system primitive neuroectodermal tumor and pineoblastoma. (21798848)	MILLER S.... Grundy R.G.	2011	CADPS
2	Astrocytoma and pineoblastoma arising sequentially in the fourth ventricle of the same patient. Case report and molecular analysis. (9361116)	Brockmeyer D.L.... Fults D.W.	1997	TP53
3	A case of pineoblastoma successfully treated with surgery, combined chemotherapy of cisplatin and etoposide, and radiotherapy (7477703)	Akiyama Y.... Nishikawa M.	1995	CGA, LNPEP

Genes related to pineoblastoma according to GeneCards:

(show all 15)

id	Symbol	Description	Score	GeneCards Section Context
1	ASMT	acetylserotonin O-methyltransferase	11.0	Disorders
2	POU5F1	POU class 5 homeobox 1	11.0
3	SAG	S-antigen; retina and pineal gland (arrestin)	11.0
4	SYP	synaptophysin	11.0
5	GFAP	glial fibrillary acidic protein	11.0
6	PCDHG@	protocadherin gamma cluster	11.0
7	RGS16	regulator of G-protein signaling 16	11.0
8	OR4C12	olfactory receptor, family 4, subfamily C, member 12	11.0
9	LNPEP	leucyl/cystinyl aminopeptidase	11.0	Publications
10	ZFHX4	zinc finger homeobox 4	11.0
11	FAM129A	family with sequence similarity 129, member A	11.0	Disorders
12	CGA	glycoprotein hormones, alpha polypeptide	11.0	Publications
13	RFX3	regulatory factor X, 3 (influences HLA class II expression)	11.0
14	CADPS	Ca++-dependent secretion activator	11.0	Publications
15	TP53	tumor protein p53	11.0	Publications

Compounds related to pineoblastoma according to GeneDecks:

(show all 18)

id	Compound	Score	Top Affiliating Genes
1	n-acetylaspartate32	10.2	SYP, GFAP
2	s 10032	10.1	SYP, GFAP
3	reticulin32	10.0	SYP, GFAP
4	8-bromo-cyclic amp32	9.8	CGA, GFAP
5	dutp32	9.7	TP53, GFAP, SYP
6	dbc-amp32	9.5	CGA, ASMT, GFAP, SYP
7	5-hydroxytryptamine32	9.4	SAG, ASMT, GFAP, SYP, RGS16
8	letrozole32 42 9 9	12.4	CGA, SYP
9	carboplatin32 34 9 9	12.3	LNPEP, CGA, TP53
10	cyclic amp32 18	10.2	SAG, CGA, ASMT, GFAP, SYP
11	forskolin32 42 9 9	11.9	SYP, GFAP, CGA, LNPEP
12	paraffin32	8.9	SYP, GFAP, TP53, CGA, SAG
13	cisplatin32 34 9 9	11.8	SYP, GFAP, TP53, CGA, LNPEP
14	norepinephrine32 9 18 9	11.8	CGA, CADPS, SYP, POU5F1
15	alanine32	8.7	LNPEP, SAG, CGA, GFAP, RGS16
16	progesterone32 42 9 18 9	12.7	SYP, GFAP, TP53, CGA, LNPEP
17	vegf32	8.6	CGA, TP53, GFAP, SYP, POU5F1
18	dopamine32 9 18 9	11.4	POU5F1, SYP, GFAP, CADPS, CGA, SAG