MCID: PNB001
MIFTS: 44

Pineoblastoma malady

Categories: Rare diseases, Neuronal diseases, Cancer diseases, Endocrine diseases

Aliases & Classifications for Pineoblastoma

Aliases & Descriptions for Pineoblastoma:

Name: Pineoblastoma 12 50 56 52 14 69
Tumor of the Pineal Region 69
Pineal Gland Neoplasm 69
Pineal Pnet 12
Pineocytoma 69
Pinealoma 42

Characteristics:

Orphanet epidemiological data:

56
pineoblastoma
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: Adolescent,Adult,Childhood,Infancy; Age of death: adolescent,late childhood;

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:1664
MeSH 42 D010871
NCIt 47 C9344
SNOMED-CT 64 31671006
Orphanet 56 ORPHA251909
UMLS via Orphanet 70 C0205898
ICD10 via Orphanet 34 C75.3
UMLS 69 C0205898

Summaries for Pineoblastoma

NIH Rare Diseases : 50 pineoblastoma is a cancerous (malignant) tumor that develops in the pineal gland.  the pineal gland is located in the brain and makes the hormone melatonin to regulate the body's sleep patterns.  pineoblastoma is a type of primitive neuroectodermal tumor (pnet).  pineoblastoma mainly affects children, but can also occur in adults.  treatment of pineoblastoma includes surgery to remove as much of the tumor as possible, followed by radiation therapy and chemotherapy. last updated: 12/15/2011

MalaCards based summary : Pineoblastoma, also known as tumor of the pineal region, is related to pineoblastoma, childhood and adult pineoblastoma, and has symptoms including headache, seizures and lethargy. An important gene associated with Pineoblastoma is DICER1 (Dicer 1, Ribonuclease III), and among its related pathways/superpathways is Neuroscience. The drugs Carboplatin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include pineal, brain and bone, and related phenotype is nervous system.

Disease Ontology : 12 A pineal gland neoplasm located in the brain.

Related Diseases for Pineoblastoma

Diseases in the Pineoblastoma family:

Adult Pineoblastoma

Diseases related to Pineoblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)
id Related Disease Score Top Affiliating Genes
1 pineoblastoma, childhood 12.2
2 adult pineoblastoma 12.0
3 pineal gland cancer 10.8
4 bone deterioration disease 10.2 DICER1 SYP
5 infiltrating renal pelvis transitional cell carcinoma 10.2 AFP SYP
6 esophagus liposarcoma 10.2 AFP POU5F1
7 exudative glomerulonephritis 10.2 DICER1 SYP
8 pediatric liposarcoma 10.2 AFP POU5F1
9 atrophic rhinitis 10.2 AFP POU5F1
10 duodenal obstruction 10.2 DICER1 SYP
11 ovarian germ cell teratoma 10.2 AFP SYP
12 biliary tract neoplasm 10.2 AFP DICER1
13 rectum leiomyoma 10.2 AFP SYP
14 inhibited male orgasm 10.2 AFP POU5F1
15 adult botryoid rhabdomyosarcoma 10.2 AFP SYP
16 fallopian tube leiomyoma 10.2 AFP POU5F1
17 medullomyoblastoma 10.2 AFP SYP
18 testicular trophoblastic tumor 10.1 AFP SYP
19 gastric duplication cysts 10.1 POU5F1 SYP
20 central nervous system disease 10.1 AFP POU5F1
21 breast mucoepidermoid carcinoma 10.1 POU5F1 SYP
22 subendocardial myocardial infarction 10.1 AFP POU5F1
23 acinar cell cystadenocarcinoma 10.1 POU5F1 SYP
24 retinoblastoma 10.1
25 struma ovarii 10.1 AFP SYP
26 thrombophlebitis 10.1 AFP GFAP
27 proliferative glomerulonephritis 10.1 AFP DICER1 SYP
28 nipple neoplasm 10.1 AFP DICER1 SYP
29 sex differentiation disease 10.1 AFP DICER1 SYP
30 spindle cell rhabdomyosarcoma 10.1 AFP DICER1 SYP
31 toxascariasis 10.0 AFP POU5F1
32 diabetes hypogonadism deafness mental retardation 10.0 GFAP SYP
33 papillary tumor of the pineal region 10.0 GFAP SYP
34 brain stem ependymoma 10.0 GFAP SYP
35 intrahepatic bile duct adenoma 10.0 GFAP SYP
36 pilocytic astrocytoma of cerebellum 10.0 GFAP SYP
37 children's interstitial lung disease 10.0 GFAP SYP
38 cervical benign neoplasm 10.0 GFAP SYP
39 myxopapillary ependymoma 10.0 GFAP SYP
40 epidermal appendage tumor 10.0 GFAP SYP
41 microinvasive cervical squamous cell carcinoma 10.0 GFAP SYP
42 nephrogenic adenoma of urinary bladder 10.0 GFAP SYP
43 paternal uniparental disomy of chromosome 1 10.0 GFAP SYP
44 cerebral folate receptor alpha deficiency 10.0 GFAP SYP
45 adenofibroma 10.0 GFAP SYP
46 pilocytic astrocytoma 10.0 GFAP SYP
47 behcet's syndrome arthropathy 10.0 GFAP SYP
48 blood group incompatibility 10.0 GFAP SYP
49 aneurysm of sinus of valsalva 10.0 GFAP SYP
50 male reproductive system disease 10.0 GFAP SYP

Graphical network of the top 20 diseases related to Pineoblastoma:



Diseases related to Pineoblastoma

Symptoms & Phenotypes for Pineoblastoma

Human phenotypes related to Pineoblastoma:

56 32 (show all 19)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 headache 56 32 Very frequent (99-80%) HP:0002315
2 seizures 56 32 Occasional (29-5%) HP:0001250
3 lethargy 56 32 Very rare (<4-1%) HP:0001254
4 amaurosis fugax 56 32 Occasional (29-5%) HP:0100576
5 behavioral abnormality 56 32 Frequent (79-30%) HP:0000708
6 increased intracranial pressure 56 32 Frequent (79-30%) HP:0002516
7 sensory neuropathy 56 32 Occasional (29-5%) HP:0000763
8 reduced visual acuity 56 32 Occasional (29-5%) HP:0007663
9 memory impairment 56 32 Frequent (79-30%) HP:0002354
10 paralysis 56 32 Occasional (29-5%) HP:0003470
11 retinoblastoma 56 32 Occasional (29-5%) HP:0009919
12 papilledema 56 32 Occasional (29-5%) HP:0001085
13 pinealoma 56 32 Obligate (100%) HP:0010799
14 progressive neurologic deterioration 56 32 Frequent (79-30%) HP:0002344
15 impaired convergence 56 32 Occasional (29-5%) HP:0000619
16 midline brain calcifications 56 32 Occasional (29-5%) HP:0007045
17 progressive visual field defects 56 32 Occasional (29-5%) HP:0007987
18 reduced consciousness/confusion 56 Very rare (<4-1%)
19 cognitive impairment 56 Frequent (79-30%)

MGI Mouse Phenotypes related to Pineoblastoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.1 CADPS DICER1 GFAP POU5F1 SAG SYP

Drugs & Therapeutics for Pineoblastoma

Drugs for Pineoblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 192)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 2, Phase 3, Phase 1 41575-94-4 10339178 498142 38904
2
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
3
Etoposide Approved Phase 2, Phase 3, Phase 1 33419-42-0 36462
4
Melphalan Approved Phase 2, Phase 3,Phase 1 148-82-3 4053 460612
5
Thiotepa Approved Phase 2, Phase 3, Phase 1 52-24-4 5453
6
Cisplatin Approved Phase 3,Phase 2 15663-27-1 84093 441203 2767
7
Lenograstim Approved Phase 3,Phase 1 135968-09-1
8
Methotrexate Approved Phase 3,Phase 2 1959-05-2, 59-05-2 126941
9
Temozolomide Approved, Investigational Phase 3,Phase 2,Phase 1 85622-93-1 5394
10
Vincristine Approved, Investigational Phase 3,Phase 2 2068-78-2, 57-22-7 5978
11
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
12
Donepezil Approved Phase 3,Phase 2 120014-06-4 3152
13
Isotretinoin Approved Phase 3 4759-48-2 5538 5282379
14
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
15
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
16
Ondansetron Approved Phase 3 99614-02-5 4595
17
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037
18
leucovorin Approved, Nutraceutical Phase 3,Phase 2 58-05-9 54575, 6560146 143
19 Etoposide phosphate Phase 2, Phase 3, Phase 1
20 Alkylating Agents Phase 3,Phase 2,Phase 1
21 Antimetabolites Phase 3,Phase 2
22 Antimetabolites, Antineoplastic Phase 3,Phase 2
23 Antimitotic Agents Phase 3,Phase 2,Phase 1
24 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
25 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
26 Antirheumatic Agents Phase 3,Phase 2,Phase 1
27 Dermatologic Agents Phase 3,Phase 2,Phase 1
28 Folic Acid Antagonists Phase 3,Phase 2
29 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
30 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
31 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
32 Vitamin B Complex Phase 3,Phase 2,Phase 1
33 Adjuvants, Anesthesia Phase 3
34 Analgesics Phase 3,Phase 2,Phase 1
35 Analgesics, Opioid Phase 3
36 Anesthetics Phase 3
37 Anesthetics, General Phase 3
38 Anesthetics, Intravenous Phase 3
39 Central Nervous System Depressants Phase 3,Phase 2
40 Liver Extracts Phase 3,Phase 1,Phase 2
41 Narcotics Phase 3
42 pancreatic polypeptide Phase 3,Phase 1
43 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
44 Cholinergic Agents Phase 3,Phase 2
45 Cholinesterase Inhibitors Phase 3,Phase 2
46 Neurotransmitter Agents Phase 3,Phase 2
47 Nootropic Agents Phase 3,Phase 2
48 Gastrointestinal Agents Phase 3,Phase 1
49 Adjuvants, Immunologic Phase 3,Phase 1
50 Antiemetics Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 65)
id Name Status NCT ID Phase
1 Stem Cell Transplant for High Risk Central Nervous System (CNS) Tumors Unknown status NCT00179803 Phase 2, Phase 3
2 Combination Chemotherapy With or Without Etoposide Followed By an Autologous Stem Cell Transplant in Treating Young Patients With Previously Untreated Malignant Brain Tumors Unknown status NCT00392886 Phase 3
3 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
4 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3
5 Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma Recruiting NCT00392327 Phase 3
6 Treatment of Patients With Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor Active, not recruiting NCT00085202 Phase 3
7 Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With Cancer Active, not recruiting NCT01987596 Phase 3
8 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Active, not recruiting NCT01346267 Phase 3
9 Phenylbutyrate to Treat Children With Progressive or Recurrent Brain Tumors Completed NCT00006450 Phase 2
10 Levetiracetam or Pregabalin in Treating Seizures in Patients Undergoing Chemotherapy and/or Radiation Therapy For Primary Brain Tumors Completed NCT00629889 Phase 2
11 Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor Completed NCT00070161 Phase 2
12 Prospective Pilot Trial to Assess a Multimodal Molecular Targeted Therapy in Children, Adolescent and Young Adults With Relapsed or Refractory High-grade Pineoblastoma Recruiting NCT02596828 Phase 2
13 Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors Recruiting NCT00983398 Phase 1, Phase 2
14 Plerixafor After Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed High Grade Glioma Recruiting NCT01977677 Phase 1, Phase 2
15 Proton Beam Radiation Therapy in Treating Young Patients Who Have Undergone Biopsy or Surgery for Medulloblastoma or Pineoblastoma Active, not recruiting NCT00105560 Phase 2
16 Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal Tumors Active, not recruiting NCT01217437 Phase 2
17 Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer Active, not recruiting NCT00445965 Phase 2
18 Risk-Adapted Therapy for Young Children With Embryonal Brain Tumors, Choroid Plexus Carcinoma, High Grade Glioma or Ependymoma Active, not recruiting NCT00602667 Phase 2
19 Crizotinib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma Active, not recruiting NCT00939770 Phase 1, Phase 2
20 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2
21 Phase II Pediatric Study With Dabrafenib in HGG Patients Not yet recruiting NCT02684058 Phase 2
22 Immune Checkpoint Inhibitor Nivolumab in People With Select Rare CNS Cancers Not yet recruiting NCT03173950 Phase 2
23 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1
24 Erlotinib Alone or in Combination With Radiation Therapy in Treating Young Patients With Refractory or Relapsed Malignant Brain Tumors or Newly Diagnosed Brain Stem Glioma Unknown status NCT00360854 Phase 1
25 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma Completed NCT01119599 Phase 1
26 Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors Completed NCT01076530 Phase 1
27 Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma Completed NCT00994500 Phase 1
28 ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors Completed NCT00946335 Phase 1
29 AZD2171 in Treating Young Patients With Recurrent, Progressive, or Refractory Primary CNS Tumors Completed NCT00326664 Phase 1
30 Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors Completed NCT00100880 Phase 1
31 Cilengitide in Treating Children With Refractory Primary Brain Tumors Completed NCT00063973 Phase 1
32 Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors Completed NCT00052780 Phase 1
33 Bortezomib and Temozolomide in Treating Patients With Brain Tumors or Other Solid Tumors That Have Not Responded to Treatment Completed NCT00544284 Phase 1
34 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1
35 Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation or Bone Marrow Transplantation in Treating Patients With Brain Cancer Completed NCT00025558 Phase 1
36 Carboxyamidotriazole and Paclitaxel in Treating Patients With Advanced Solid Tumors or Refractory Lymphomas Completed NCT00019019 Phase 1
37 Calcitriol Plus Carboplatin in Treating Patients With Advanced Solid Tumors Completed NCT00008086 Phase 1
38 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
39 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1
40 PTC299 in Treating Young Patients With Refractory or Recurrent Primary Central Nervous System Tumors Completed NCT01158300 Phase 1
41 Enzastaurin in Treating Young Patients With Refractory Primary CNS Tumors Completed NCT00503724 Phase 1
42 Palbociclib Isethionate in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors Recruiting NCT02255461 Phase 1
43 Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Newly Diagnosed Brain Tumors Terminated NCT00110032 Phase 1
44 Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia Terminated NCT01088763 Phase 1
45 Melphalan With BBBD in Treating Patients With Brain Malignancies Terminated NCT00253721 Phase 1
46 MT2004-30: Tomotherapy for Solid Tumors Terminated NCT00623077 Phase 1
47 MK0752 in Treating Young Patients With Recurrent or Refractory CNS Cancer Terminated NCT00572182 Phase 1
48 Topotecan in Treating Young Patients With Neoplastic Meningitis Due to Leukemia, Lymphoma, or Solid Tumors Terminated NCT00112619 Phase 1
49 Talotrexin in Treating Young Patients With Recurrent Solid Tumors or Leukemia That is Recurrent or Does Not Respond to Treatment Withdrawn NCT00458744 Phase 1
50 Morphological Analysis of the Pineal Gland in Pediatric Retinoblastoma Patients Using Magnetic Resonance Imaging Completed NCT01884194

Search NIH Clinical Center for Pineoblastoma

Cochrane evidence based reviews: pinealoma

Genetic Tests for Pineoblastoma

Anatomical Context for Pineoblastoma

MalaCards organs/tissues related to Pineoblastoma:

39
Pineal, Brain, Bone, Spinal Cord

The Foundational Model of Anatomy Ontology organs/tissues related to Pineoblastoma:

18
The Brain

Publications for Pineoblastoma

Articles related to Pineoblastoma:

(show top 50) (show all 78)
id Title Authors Year
1
A rare case of a pineoblastoma with a rhabdomyoblastic component. ( 27775846 )
2016
2
Isolation and characterization of tumorspheres from a recurrent pineoblastoma patient: Feasibility of a patient-derived xenograft. ( 27277549 )
2016
3
MRI-based assessment of the pineal gland in a large population of children aged 0-5A years and comparison with pineoblastoma: part I, the solid gland. ( 27130616 )
2016
4
Clinical Reasoning: Left hemiparesis, ataxia, and optic neuritis in a child previously treated for pineoblastoma. ( 27163667 )
2016
5
MRI-based assessment of the pineal gland in a large population of children aged 0-5A years and comparison with pineoblastoma: part II, the cystic gland. ( 27130617 )
2016
6
Evaluation of age-dependent treatment strategies for children and young adults with pineoblastoma: analysis of pooled European Society for Paediatric Oncology (SIOP-E) and US Head Start data. ( 28011926 )
2016
7
Leptomeningeal metastases in pineoblastoma. ( 26123467 )
2015
8
Complete regression of adult pineoblastoma following radiotherapy: A case report and review of the literature. ( 26622845 )
2015
9
Magnetic resonance imaging based morphologic evaluation of the pineal gland for suspected pineoblastoma in retinoblastoma patients and age-matched controls. ( 26671110 )
2015
10
The postirradiation incidence of cavernous angioma is higher in patients with childhood pineoblastoma or primitive neuroectodermal tumors than medulloblastoma. ( 25690449 )
2015
11
A Case of Radiation-Induced Osteosarcoma after the Treatment of Pineoblastoma. ( 26605276 )
2015
12
Intraosseous Metastasizing of Pineoblastoma into the Anterior Skull Base, Calvarial Bones, and Vertebrae. ( 26858918 )
2015
13
Clinical Outcomes and Patterns of Failure in Pineoblastoma: A 30-year Single Institution Retrospective Review. ( 25045788 )
2014
14
From a Suspicious Cystic Pineal Gland to Pineoblastoma in a Patient with Familial Unilateral Retinoblastoma. ( 24940935 )
2014
15
Germ-line and somatic DICER1 mutations in pineoblastoma. ( 25022261 )
2014
16
Incidence of pineal gland cyst and pineoblastoma in children with retinoblastoma during the chemoreduction era. ( 23876864 )
2013
17
Incidence of pineal gland cyst and pineoblastoma in children with retinoblastoma during the chemoreduction era. ( 24238207 )
2013
18
Germline DICER1 mutation and associated loss of heterozygosity in a pineoblastoma. ( 22717647 )
2012
19
Donor transmission of pineoblastoma in a two-yr-old male recipient of a multivisceral transplant: a case report. ( 21281415 )
2012
20
The long-term postsurgical prognosis of patients with pineoblastoma. ( 21717450 )
2012
21
Contemporary management of pineoblastoma. ( 21801990 )
2011
22
Genome-wide molecular characterization of central nervous system primitive neuroectodermal tumor and pineoblastoma. ( 21798848 )
2011
23
Post-chemotherapy maturation of a pineoblastoma. ( 20224924 )
2010
24
Post-radiation reactive changes in a single vertebral body mimicking metastatic pineoblastoma. ( 19877784 )
2009
25
Severe cytomegalic pneumonitis associated with pulmonary aspergillosis in a child with immunosuppression due to chemotherapy for treating pineoblastoma. ( 19287944 )
2009
26
Transformation of a low-grade pineal parenchymal tumour to secondary pineoblastoma. ( 19284482 )
2009
27
Response of an adult patient with pineoblastoma to vorinostat and retinoic acid. ( 19506816 )
2009
28
Outcome of pediatric pineoblastoma after surgery, radiation and chemotherapy. ( 18415046 )
2008
29
Diffusion-weighted MR images and pineoblastoma: diagnosis and follow-up. ( 18392417 )
2008
30
Childhood pineoblastoma: experiences from the prospective multicenter trials HIT-SKK87, HIT-SKK92 and HIT91. ( 16941074 )
2007
31
Cytogenetics of pineoblastoma: four new cases and a literature review. ( 17011992 )
2006
32
Congenital pineoblastoma and parameningeal rhabdomyosarcoma: concurrent two embryonal tumors in a young infant. ( 16283194 )
2006
33
Molecular genetics of supratentorial primitive neuroectodermal tumors and pineoblastoma. ( 16398467 )
2005
34
Management and survival of pineoblastoma: an analysis of 34 adults from the brain tumor registry of Japan. ( 15782004 )
2005
35
Osseous metastasis of pineoblastoma: a case report and review of the literature. ( 16078108 )
2005
36
Pineal parenchymal tumours: II. On the aggressive behaviour of pineoblastoma in patients with an inherited mutation of the RB1 gene. ( 15214647 )
2004
37
Pathologic quiz case: a 15-year-old girl with an intracranial midline mass. Pineoblastoma, World Health Organization Grade IV. ( 15163221 )
2004
38
Pathology case of the month. Tumor of the pineal region. Pineoblastoma, recurrent. ( 15233382 )
2004
39
Surgical treatment of a mixed pineocytoma/pineoblastoma in a 72-year-old patient. ( 12021888 )
2002
40
Detection of a pineoblastoma with large central cyst in a young child. ( 11981625 )
2002
41
Screening for pineoblastoma in patients with retinoblastoma. ( 12470168 )
2002
42
Vertebral metastases from pineoblastoma. ( 11419982 )
2001
43
Non-resective management of pineoblastoma. ( 11108118 )
2000
44
Neuroradiological characteristics of pineocytoma and pineoblastoma. ( 10952183 )
2000
45
Long-term survival following extra-neural metastasis from a pineoblastoma. ( 11083078 )
2000
46
Pineoblastoma showing unusual ventricular extension in a young adult--case report. ( 10487041 )
1999
47
F-18 FDG PET scan of a metastatic pineoblastoma. ( 10069738 )
1999
48
Pineoblastoma presenting in familial adenomatous polyposis (FAP): random association, FAP variant or Turcot syndrome? ( 10070471 )
1998
49
A new pineoblastoma cell line, PER-480, with der(10)t(10;17), der(16)t(1;16), and enhanced MYC expression in the absence of gene amplification. ( 9428362 )
1998
50
Astrocytoma and pineoblastoma arising sequentially in the fourth ventricle of the same patient. Case report and molecular analysis. ( 9361116 )
1997

Variations for Pineoblastoma

ClinVar genetic disease variations for Pineoblastoma:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 DICER1 NM_177438.2(DICER1): c.5103C> A (p.Tyr1701Ter) single nucleotide variant Pathogenic rs875989780 GRCh38 Chromosome 14, 95094149: 95094149
2 DICER1 NM_177438.2(DICER1): c.4754C> G (p.Ser1585Ter) single nucleotide variant Pathogenic rs875989779 GRCh37 Chromosome 14, 95562503: 95562503
3 DICER1 NM_177438.2(DICER1): c.4633dupT (p.Ser1545Phefs) duplication Pathogenic rs875989781 GRCh38 Chromosome 14, 95096287: 95096287
4 DICER1 NM_177438.2(DICER1): c.4407_4410delTTCT (p.Ser1470Leufs) deletion Pathogenic rs875989784 GRCh37 Chromosome 14, 95562847: 95562850
5 DICER1 NM_177438.2(DICER1): c.4050+1G> A single nucleotide variant Pathogenic rs875989783 GRCh38 Chromosome 14, 95103345: 95103345
6 DICER1 NM_177438.2(DICER1): c.1498A> T (p.Lys500Ter) single nucleotide variant Pathogenic rs875989782 GRCh38 Chromosome 14, 95117633: 95117633

Expression for Pineoblastoma

Search GEO for disease gene expression data for Pineoblastoma.

Pathways for Pineoblastoma

Pathways related to Pineoblastoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.31 GFAP SAG SYP

GO Terms for Pineoblastoma

Cellular components related to Pineoblastoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.17 AFP ASMT CADPS DICER1 GFAP POU5F1

Sources for Pineoblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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