MCID: PNB001
MIFTS: 40

Pineoblastoma malady

Neuronal diseases, Cancer diseases categories

Summaries for Pineoblastoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Pineoblastoma is a cancerous (malignant) tumor that develops in the pineal gland.  the pineal gland is located in the brain and makes the hormone melatonin to regulate the body's sleep patterns.  pineoblastoma is a type of primitive neuroectodermal tumor (pnet).  pineoblastoma mainly affects children, but can also occur in adults.  treatment of pineoblastoma includes surgery to remove as much of the tumor as possible, followed by radiation therapy and chemotherapy. last updated: 12/15/2011

MalaCards: Pineoblastoma, also known as pineal pnet, is related to retinoblastoma and medulloepithelioma. An important gene associated with Pineoblastoma is ASMT (acetylserotonin O-methyltransferase). The compounds n-acetylaspartate and s 100 have been mentioned in the context of this disorder. Affiliated tissues include the brain, pineal and brain.

Disease Ontology:8 A pineal gland neoplasm located in the brain.

Wikipedia:63 Pinealoblastoma is a tumor of the pineal gland. more...

Aliases & Classifications for Pineoblastoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

pineoblastoma 8 42 10 44 48 60
pineal pnet 8


External Ids:

Disease Ontology8 DOID:1664
NCIt39 C9344
SNOMED-CT56 31671006
MeSH34 D010871
SNOMED-CT via Orphanet57 31671006

Related Diseases for Pineoblastoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Pineoblastoma family:

Adult Pineoblastoma

Diseases related to Pineoblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1retinoblastoma30.4TP53, SYP, GFAP, ASMT, SAG
2medulloepithelioma29.9SYP
3medulloblastoma29.9TP53, GFAP, SYP, SAG
4adult pineoblastoma10.4
5pineoblastoma, childhood10.4
6primitive neuroectodermal tumor10.2
7trilateral retinoblastoma10.1
8dysembryoplastic neuroepithelial tumor10.0SYP
9ganglioneuroblastoma10.0SYP
10giant cell glioblastoma10.0GFAP
11melanotic neuroectodermal tumor10.0SYP
12rhabdoid tumor10.0SYP
13gemistocytic astrocytoma10.0GFAP
14gliomatosis cerebri10.0GFAP
15myoepithelioma10.0GFAP
16subependymal giant cell astrocytoma10.0GFAP, SYP
17binswanger's disease10.0GFAP, SYP
18papillary ependymoma10.0SYP, GFAP
19leydig cell tumor10.0CGA
20ganglioglioma10.0SYP, GFAP
21hemangioblastoma10.0GFAP, SYP
22central neurocytoma10.0SYP, GFAP
23pilocytic astrocytoma10.0SYP, GFAP
24anaplastic oligodendroglioma10.0GFAP
25ependymoma10.0SYP, GFAP
26teratocarcinoma10.0POU5F1, SYP
27placental site trophoblastic tumor10.0LNPEP, CGA
28trophoblastic neoplasm10.0CGA, LNPEP
29pineocytoma10.0GFAP, SAG, SYP, ASMT
30teratoma10.0GFAP, CGA, POU5F1
31choriocarcinoma10.0LNPEP, CGA
32choroid plexus papilloma10.0GFAP, TP53
33neuroblastoma10.0SYP, TP53
34brain cancer10.0GFAP, TP53, SYP
35pituitary adenoma10.0SYP, POU5F1, CGA
36seminoma10.0LNPEP, POU5F1, CGA
37germinoma10.0POU5F1, CGA
38tuberous sclerosis10.0SYP, GFAP
39oligodendroglioma10.0TP53, SYP, GFAP
40gestational trophoblastic neoplasm10.0LNPEP, CGA
41chordoid glioma10.0RGS16, ZFHX4, RFX3
42adenoma10.0SAG, TP53, SYP, CGA
43childhood medulloblastoma10.0FAM129A, CADPS, OR4C12
44bilateral retinoblastoma9.9
45unilateral retinoblastoma9.9
46familial adenomatous polyposis9.9
47supratentorial primitive neuroectodermal tumor9.9
48neuronitis9.9
49aspergillosis9.9
50astrocytoma9.9

Graphical network of the top 20 diseases related to Pineoblastoma:



Diseases related to pineoblastoma

Clinical Features for Pineoblastoma

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Drugs & Therapeutics for Pineoblastoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Pineoblastoma

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Genetic Tests for Pineoblastoma

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Anatomical Context for Pineoblastoma

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Pineoblastoma:

32
Pineal, Brain, Bone, Spinal cord

FMA organs/tissues related to Pineoblastoma:

14
The brain

Animal Models for Pineoblastoma or affiliated genes

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Publications for Pineoblastoma

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Sources:
50PubMed
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Articles related to Pineoblastoma:

(show top 50)    (show all 63)
idTitleAuthorsYear
1
Incidence of pineal gland cyst and pineoblastoma in children with retinoblastoma during the chemoreduction era. (23876864)
2013
2
Incidence of pineal gland cyst and pineoblastoma in children with retinoblastoma during the chemoreduction era. (24238207)
2013
3
Donor transmission of pineoblastoma in a two-yr-old male recipient of a multivisceral transplant: a case report. (21281415)
2012
4
Germline DICER1 mutation and associated loss of heterozygosity in a pineoblastoma. (22717647)
2012
5
The long-term postsurgical prognosis of patients with pineoblastoma. (21717450)
2012
6
Contemporary management of pineoblastoma. (21801990)
2011
7
Post-chemotherapy maturation of a pineoblastoma. (20224924)
2010
8
Severe cytomegalic pneumonitis associated with pulmonary aspergillosis in a child with immunosuppression due to chemotherapy for treating pineoblastoma. (19287944)
2009
9
Post-radiation reactive changes in a single vertebral body mimicking metastatic pineoblastoma. (19877784)
2009
10
Transformation of a low-grade pineal parenchymal tumour to secondary pineoblastoma. (19284482)
2009
11
Outcome of pediatric pineoblastoma after surgery, radiation and chemotherapy. (18415046)
2008
12
Congenital pineoblastoma and parameningeal rhabdomyosarcoma: concurrent two embryonal tumors in a young infant. (16283194)
2006
13
Cytogenetics of pineoblastoma: four new cases and a literature review. (17011992)
2006
14
Molecular genetics of supratentorial primitive neuroectodermal tumors and pineoblastoma. (16398467)
2005
15
Pineal parenchymal tumours: II. On the aggressive behaviour of pineoblastoma in patients with an inherited mutation of the RB1 gene. (15214647)
2004
16
Pathologic quiz case: a 15-year-old girl with an intracranial midline mass. Pineoblastoma, World Health Organization Grade IV. (15163221)
2004
17
Pathology case of the month. Tumor of the pineal region. Pineoblastoma, recurrent. (15233382)
2004
18
Surgical treatment of a mixed pineocytoma/pineoblastoma in a 72-year-old patient. (12021888)
2002
19
Detection of a pineoblastoma with large central cyst in a young child. (11981625)
2002
20
Screening for pineoblastoma in patients with retinoblastoma. (12470168)
2002
21
Vertebral metastases from pineoblastoma. (11419982)
2001
22
Long-term survival following extra-neural metastasis from a pineoblastoma. (11083078)
2000
23
Non-resective management of pineoblastoma. (11108118)
2000
24
Neuroradiological characteristics of pineocytoma and pineoblastoma. (10952183)
2000
25
F-18 FDG PET scan of a metastatic pineoblastoma. (10069738)
1999
26
Pineoblastoma showing unusual ventricular extension in a young adult--case report. (10487041)
1999
27
A new pineoblastoma cell line, PER-480, with der(10)t(10;17), der(16)t(1;16), and enhanced MYC expression in the absence of gene amplification. (9428362)
1998
28
Pineoblastoma presenting in familial adenomatous polyposis (FAP): random association, FAP variant or Turcot syndrome? (10070471)
1998
29
Astrocytoma and pineoblastoma arising sequentially in the fourth ventricle of the same patient. Case report and molecular analysis. (9361116)
1997
30
Treatment of patients with pineoblastoma with high dose cyclophosphamide. (8614374)
1996
31
Pineoblastoma in adults. (7501100)
1995
32
Lack of efficacy of postoperative chemotherapy and delayed radiation in very young children with pineoblastoma. Pediatric Oncology Group. (7753001)
1995
33
A case of pineoblastoma successfully treated with surgery, combined chemotherapy of cisplatin and etoposide, and radiotherapy]. (7477703)
1995
34
Pineoblastoma imaged during bone scintigraphy. (8565362)
1995
35
Nonresective treatment of pineoblastoma: a case report. (8553260)
1995
36
Peritoneal metastases in two patients with pineoblastoma and ventriculo-peritoneal shunts. (8152405)
1994
37
Successful combination chemotherapy (cisplatin, vinblastine, and bleomycin) with small-dose irradiation in the treatment of pineoblastoma metastasized into spinal cord: case report. (7688912)
1993
38
Metastatic pineoblastoma via a ventriculoperitoneal shunt: CT demonstration. (1394082)
1992
39
Concurrent benign teratoid medulloepithelioma and pineoblastoma. (1513537)
1992
40
Phase II treatment of medulloblastoma and pineoblastoma with melphalan: clinical therapy based on experimental models of human medulloblastoma. (2738624)
1989
41
Interstitial deletion of chromosome 11q in a pineoblastoma. (2731139)
1989
42
Pineoblastoma in a cockatiel. (3196277)
1988
43
Pineoblastoma with neuronal differentiation--immunohistochemical and immunocytochemical studies. (3066852)
1988
44
Computed tomography of familial pineoblastoma. (3944313)
1986
45
Concurrent pineoblastoma and unilateral retinoblastoma: a forme fruste of trilateral retinoblastoma? (4047365)
1985
46
Trilateral retinoblastoma. Pineoblastoma (ectopic intracranial retinoblastoma) associated with bilateral retinoblastoma. (6544387)
1984
47
Pineoblastoma with ganglionic and glial differentiation: report of two cases. (7349581)
1981
48
The separation of pineocytoma from pineoblastoma. (6986979)
1980
49
Pineoblastoma: an electron microscopic study. (498040)
1979
50
Pineoblastoma with spontaneous intra and extracranial metastasis. (4548088)
1974

Genetic Variations for Pineoblastoma

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Expression for genes affiliated with Pineoblastoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pineoblastoma

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Pathways for genes affiliated with Pineoblastoma

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Compounds for genes affiliated with Pineoblastoma

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44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Pineoblastoma according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1n-acetylaspartate4410.2GFAP, SYP
2s 1004410.2GFAP, SYP
3reticulin4410.0GFAP, SYP
48-bromo-cyclic amp4410.0CGA, GFAP
5dutp449.9TP53, GFAP, SYP
6letrozole44 49 59 1112.9SYP, CGA
7dbc-amp449.7ASMT, GFAP, SYP, CGA
8carboplatin44 49 1111.5TP53, LNPEP, CGA
9cyclic amp44 2410.5SAG, CGA, SYP, GFAP, ASMT
105-hydroxytryptamine449.4ASMT, GFAP, RGS16, SYP, SAG
11paraffin449.4SAG, CGA, SYP, GFAP, TP53
12norepinephrine44 11 2411.3CADPS, CGA, SYP, POU5F1
13vegf449.2TP53, GFAP, POU5F1, SYP, CGA
14forskolin44 49 1111.1GFAP, LNPEP, SYP, CGA
15cisplatin44 49 59 1112.1CGA, SYP, LNPEP, GFAP, TP53
16progesterone44 59 28 11 2413.0CGA, SYP, LNPEP, GFAP, TP53
17dopamine44 28 11 2412.0CADPS, SAG, CGA, SYP, POU5F1, GFAP
18leucine448.9GFAP, LNPEP, SYP, SAG
19alanine448.6SAG, CGA, LNPEP, RGS16, GFAP

GO Terms for genes affiliated with Pineoblastoma

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16Gene Ontology
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Molecular functions related to Pineoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription regulatory region DNA bindingGO:0442129.1RFX3, TP53, POU5F1

Products for genes affiliated with Pineoblastoma

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Sources for Pineoblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet