MCID: PNB001
MIFTS: 51

Pineoblastoma

Categories: Rare diseases, Cancer diseases, Endocrine diseases, Neuronal diseases

Aliases & Classifications for Pineoblastoma

MalaCards integrated aliases for Pineoblastoma:

Name: Pineoblastoma 12 49 55 51 14 69
Tumor of the Pineal Region 69
Pineal Gland Neoplasm 69
Pineal Pnet 12
Pineocytoma 69
Pinealoma 41

Characteristics:

Orphanet epidemiological data:

55
pineoblastoma
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: Adolescent,Adult,Childhood,Infancy; Age of death: adolescent,late childhood;

Classifications:

Orphanet: 55  
Rare neurological diseases


Summaries for Pineoblastoma

NIH Rare Diseases : 49 Pineoblastoma is a cancerous (malignant) tumor that develops in the pineal gland.  The pineal gland is located in the brain and makes the hormonemelatonin to regulate the body's sleep patterns.  Pineoblastoma is a type of primitive neuroectodermal tumor (PNET).  Pineoblastoma mainly affects children, but can also occur in adults.  Treatment of pineoblastoma includes surgery to remove as much of the tumor as possible, followed by radiation therapy and chemotherapy. Last updated: 12/15/2011

MalaCards based summary : Pineoblastoma, also known as tumor of the pineal region, is related to medulloepithelioma and pineocytoma, and has symptoms including pinealoma, headache and behavioral abnormality. An important gene associated with Pineoblastoma is DICER1 (Dicer 1, Ribonuclease III), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Carboplatin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include the brain, brain and pineal, and related phenotype is nervous system.

Disease Ontology : 12 A pineal gland neoplasm located in the brain.

Related Diseases for Pineoblastoma

Diseases in the Pineoblastoma family:

Adult Pineoblastoma

Diseases related to Pineoblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 medulloepithelioma 29.5 GFAP SYP
2 pineocytoma 28.7 ASMT GFAP SAG SYP
3 pineal gland cancer 28.0 ASMT DICER1 GFAP SAG SYP
4 pineoblastoma, childhood 12.4
5 adult pineoblastoma 12.1
6 sertoli-leydig cell tumor 10.3 AFP DICER1
7 reproductive organ benign neoplasm 10.3 AFP DICER1
8 malignant sertoli cell tumor 10.3 AFP SYP
9 extragonadal germ cell cancer 10.3 AFP POU5F1
10 embryonal testis carcinoma 10.2 AFP POU5F1
11 ovarian embryonal carcinoma 10.2 AFP POU5F1
12 pulmonary blastoma 10.2 DICER1 SYP
13 intratubular embryonal carcinoma 10.2 AFP POU5F1
14 atypical choroid plexus papilloma 10.2 DICER1 SYP
15 endometrial small cell carcinoma 10.2 AFP SYP
16 testicular infarct 10.2 AFP POU5F1
17 mediastinal cancer 10.2 AFP SYP
18 mature teratoma 10.2 AFP POU5F1
19 seminal vesicle tumor 10.2 AFP SYP
20 pancreatoblastoma 10.2 AFP SYP
21 blastoma 10.2 DICER1 SYP
22 retinoblastoma 10.2
23 mixed germ cell cancer 10.2 AFP POU5F1
24 pancreatic cystadenocarcinoma 10.2 AFP SYP
25 extragonadal seminoma 10.1 AFP POU5F1
26 venous hemangioma 10.1 POU5F1 SYP
27 non-functioning pancreatic endocrine tumor 10.1 POU5F1 SYP
28 germ cell and embryonal cancer 10.1 AFP POU5F1
29 aging 10.1
30 melanotic medulloblastoma 10.0 AFP GFAP
31 botryoid rhabdomyosarcoma 10.0 AFP DICER1 SYP
32 sex cord-gonadal stromal tumor 10.0 AFP DICER1 SYP
33 desmoplastic infantile ganglioglioma 10.0 GFAP SYP
34 extraventricular neurocytoma 10.0 GFAP SYP
35 lung combined type small cell carcinoma 9.9 GFAP SYP
36 cellular ependymoma 9.9 GFAP SYP
37 testicular yolk sac tumor 9.9 AFP POU5F1
38 gangliocytoma 9.9 GFAP SYP
39 rhabdoid meningioma 9.9 GFAP SYP
40 pilomyxoid astrocytoma 9.9 GFAP SYP
41 chordoid meningioma 9.9 GFAP SYP
42 subependymal glioma 9.9 GFAP SYP
43 chiari malformation 9.9 GFAP SYP
44 dysembryoplastic neuroepithelial tumor 9.9 GFAP SYP
45 cerebral neuroblastoma 9.9 GFAP SYP
46 benign ependymoma 9.9 GFAP SYP
47 astroblastoma 9.9 GFAP SYP
48 cerebral ventricle cancer 9.9 GFAP SYP
49 cerebrum cancer 9.9 GFAP SYP
50 melanotic neuroectodermal tumor 9.9 GFAP SYP

Graphical network of the top 20 diseases related to Pineoblastoma:



Diseases related to Pineoblastoma

Symptoms & Phenotypes for Pineoblastoma

Human phenotypes related to Pineoblastoma:

55 31 (show all 19)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 pinealoma 55 31 obligate (100%) Obligate (100%) HP:0010799
2 headache 55 31 hallmark (90%) Very frequent (99-80%) HP:0002315
3 behavioral abnormality 55 31 frequent (33%) Frequent (79-30%) HP:0000708
4 progressive neurologic deterioration 55 31 frequent (33%) Frequent (79-30%) HP:0002344
5 memory impairment 55 31 frequent (33%) Frequent (79-30%) HP:0002354
6 increased intracranial pressure 55 31 frequent (33%) Frequent (79-30%) HP:0002516
7 impaired convergence 55 31 occasional (7.5%) Occasional (29-5%) HP:0000619
8 sensory neuropathy 55 31 occasional (7.5%) Occasional (29-5%) HP:0000763
9 papilledema 55 31 occasional (7.5%) Occasional (29-5%) HP:0001085
10 seizures 55 31 occasional (7.5%) Occasional (29-5%) HP:0001250
11 paralysis 55 31 occasional (7.5%) Occasional (29-5%) HP:0003470
12 midline brain calcifications 55 31 occasional (7.5%) Occasional (29-5%) HP:0007045
13 reduced visual acuity 55 31 occasional (7.5%) Occasional (29-5%) HP:0007663
14 progressive visual field defects 55 31 occasional (7.5%) Occasional (29-5%) HP:0007987
15 retinoblastoma 55 31 occasional (7.5%) Occasional (29-5%) HP:0009919
16 amaurosis fugax 55 31 occasional (7.5%) Occasional (29-5%) HP:0100576
17 lethargy 55 31 very rare (1%) Very rare (<4-1%) HP:0001254
18 cognitive impairment 55 Frequent (79-30%)
19 reduced consciousness/confusion 55 Very rare (<4-1%)

MGI Mouse Phenotypes related to Pineoblastoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.1 CADPS DICER1 GFAP POU5F1 SAG SYP

Drugs & Therapeutics for Pineoblastoma

Drugs for Pineoblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 191)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 2, Phase 3, Phase 1 41575-94-4 10339178 38904 498142
2
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
3
Etoposide Approved Phase 2, Phase 3, Phase 1 33419-42-0 36462
4
Melphalan Approved Phase 2, Phase 3,Phase 1 148-82-3 460612 4053
5 Thiotepa Approved, Investigational Phase 2, Phase 3, Phase 1 52-24-4 5453
6
Cisplatin Approved Phase 3,Phase 2 15663-27-1 2767 441203 84093
7
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1 135968-09-1
8
Methotrexate Approved Phase 3,Phase 2 1959-05-2, 59-05-2 126941
9
Temozolomide Approved, Investigational Phase 3,Phase 2,Phase 1 85622-93-1 5394
10
Vincristine Approved, Investigational Phase 3,Phase 2 2068-78-2, 57-22-7 5978
11
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
12
Donepezil Approved Phase 3,Phase 2 120014-06-4 3152
13
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
14
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
15
Ondansetron Approved Phase 3 99614-02-5 4595
16
Isotretinoin Approved Phase 3 4759-48-2 5282379 5538
17
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 59-30-3 6037
18
leucovorin Approved, Nutraceutical Phase 3,Phase 2 58-05-9 143 6006
19 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
20 Etoposide phosphate Phase 2, Phase 3, Phase 1
21 Alkylating Agents Phase 3,Phase 2,Phase 1
22 Antimetabolites Phase 3,Phase 2
23 Antimetabolites, Antineoplastic Phase 3,Phase 2
24 Antimitotic Agents Phase 3,Phase 2,Phase 1
25 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
26 Antirheumatic Agents Phase 3,Phase 2,Phase 1
27 Dermatologic Agents Phase 3,Phase 2,Phase 1
28 Folic Acid Antagonists Phase 3,Phase 2
29 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
30 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
31 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
32 Vitamin B Complex Phase 3,Phase 2
33 Adjuvants, Anesthesia Phase 3
34 Analgesics Phase 3,Phase 2,Phase 1
35 Analgesics, Opioid Phase 3
36 Anesthetics Phase 3
37 Anesthetics, General Phase 3
38 Anesthetics, Intravenous Phase 3
39 Central Nervous System Depressants Phase 3,Phase 2
40 Liver Extracts Phase 3,Phase 1,Phase 2
41 Narcotics Phase 3
42 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
43 Cholinergic Agents Phase 3,Phase 2
44 Cholinesterase Inhibitors Phase 3,Phase 2
45 Neurotransmitter Agents Phase 3,Phase 2
46 Nootropic Agents Phase 3,Phase 2
47 Antiemetics Phase 3,Phase 1
48 Autonomic Agents Phase 3,Phase 1
49 BB 1101 Phase 3,Phase 2,Phase 1
50 Dexamethasone acetate Phase 3,Phase 2,Phase 1 1177-87-3

Interventional clinical trials:

(show top 50) (show all 81)

# Name Status NCT ID Phase Drugs
1 Stem Cell Transplant for High Risk Central Nervous System (CNS) Tumors Unknown status NCT00179803 Phase 2, Phase 3
2 Combination Chemotherapy With or Without Etoposide Followed By an Autologous Stem Cell Transplant in Treating Young Patients With Previously Untreated Malignant Brain Tumors Unknown status NCT00392886 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide;methotrexate;temozolomide;thiotepa;vincristine sulfate
3 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
4 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
5 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
6 Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma Recruiting NCT00392327 Phase 3 Vincristine Sulfate;Carboplatin;Cisplatin;Cyclophosphamide;Isotretinoin
7 Treatment of Patients With Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor Active, not recruiting NCT00085202 Phase 3 cisplatin;cyclophosphamide;vincristine
8 Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With Cancer Active, not recruiting NCT01987596 Phase 3
9 Proton Beam Radiation Therapy in Treating Patients With Low Grade Gliomas Unknown status NCT01024907 Phase 1, Phase 2
10 Phenylbutyrate to Treat Children With Progressive or Recurrent Brain Tumors Completed NCT00006450 Phase 2 Phenylbutyrate
11 Levetiracetam or Pregabalin in Treating Seizures in Patients Undergoing Chemotherapy and/or Radiation Therapy For Primary Brain Tumors Completed NCT00629889 Phase 2 levetiracetam;pregabalin
12 Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor Completed NCT00070161 Phase 2 donepezil hydrochloride
13 Combination Chemotherapy, Surgery or Radiation Therapy, and Peripheral Stem Cell Transplant in Treating Patients With Recurrent Medulloblastoma or Primitive Neuroectodermal and Pineal Tumors Completed NCT00025077 Phase 2 carboplatin;cyclophosphamide;thiotepa
14 Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer Completed NCT00492089 Phase 2 bevacizumab;placebo
15 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Tumors Completed NCT00003461 Phase 1, Phase 2
16 Prospective Pilot Trial to Assess a Multimodal Molecular Targeted Therapy in Children, Adolescent and Young Adults With Relapsed or Refractory High-grade Pineoblastoma Recruiting NCT02596828 Phase 2 Temozolomide;Irinotecan;Dasatinib;Rapamycin
17 Phase II Pediatric Study With Dabrafenib in Combination With Trametinib in Patients With HGG Recruiting NCT02684058 Phase 2 dabrafenib;trametinib
18 Immune Checkpoint Inhibitor Nivolumab in People With Select Rare CNS Cancers Recruiting NCT03173950 Phase 2 Nivolumab
19 Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors Recruiting NCT00983398 Phase 1, Phase 2 Carboplatin;Mannitol;Melphalan;Sodium Thiosulfate
20 Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal Tumors Active, not recruiting NCT01217437 Phase 2 Irinotecan Hydrochloride;Temozolomide
21 Plerixafor After Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed High Grade Glioma Active, not recruiting NCT01977677 Phase 1, Phase 2 temozolomide;plerixafor
22 Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer Active, not recruiting NCT00445965 Phase 2
23 Risk-Adapted Therapy for Young Children With Embryonal Brain Tumors, Choroid Plexus Carcinoma, High Grade Glioma or Ependymoma Active, not recruiting NCT00602667 Phase 2 Induction Chemotherapy;Low-Risk Therapy;High-Risk Therapy;Intermediate-Risk Therapy
24 Crizotinib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma Active, not recruiting NCT00939770 Phase 1, Phase 2 crizotinib
25 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
26 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
27 Erlotinib Alone or in Combination With Radiation Therapy in Treating Young Patients With Refractory or Relapsed Malignant Brain Tumors or Newly Diagnosed Brain Stem Glioma Unknown status NCT00360854 Phase 1 erlotinib hydrochloride
28 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
29 Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors Completed NCT01076530 Phase 1 vorinostat;temozolomide
30 Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma Completed NCT00994500 Phase 1 vorinostat;bortezomib
31 ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors Completed NCT00946335 Phase 1 veliparib;temozolomide
32 AZD2171 in Treating Young Patients With Recurrent, Progressive, or Refractory Primary CNS Tumors Completed NCT00326664 Phase 1 Cediranib Maleate
33 Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors Completed NCT00100880 Phase 1 lenalidomide
34 Cilengitide in Treating Children With Refractory Primary Brain Tumors Completed NCT00063973 Phase 1 cilengitide
35 Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors Completed NCT00052780 Phase 1 O6-benzylguanine;temozolomide
36 Bortezomib and Temozolomide in Treating Patients With Brain Tumors or Other Solid Tumors That Have Not Responded to Treatment Completed NCT00544284 Phase 1 bortezomib;temozolomide
37 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
38 Calcitriol Plus Carboplatin in Treating Patients With Advanced Solid Tumors Completed NCT00008086 Phase 1 carboplatin
39 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1 docetaxel;thalidomide
40 Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation or Bone Marrow Transplantation in Treating Patients With Brain Cancer Completed NCT00025558 Phase 1 carboplatin;temozolomide;thiotepa
41 Carboxyamidotriazole and Paclitaxel in Treating Patients With Advanced Solid Tumors or Refractory Lymphomas Completed NCT00019019 Phase 1 carboxyamidotriazole;paclitaxel
42 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
43 PTC299 in Treating Young Patients With Refractory or Recurrent Primary Central Nervous System Tumors Completed NCT01158300 Phase 1 VEGF inhibitor PTC299
44 Enzastaurin in Treating Young Patients With Refractory Primary CNS Tumors Completed NCT00503724 Phase 1 enzastaurin hydrochloride
45 Stereotactic Radiosurgery in Treating Patients With Brain Tumors Completed NCT00019578 Phase 1
46 Liposomal Doxorubicin in Treating Children With Refractory Solid Tumors Completed NCT00019630 Phase 1 doxorubicin HCl liposome
47 Radiolabeled Monoclonal Antibody Therapy After Radiation Therapy in Treating Patients With Primary Brain Tumors Completed NCT00003484 Phase 1 carmustine;irinotecan hydrochloride
48 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1 entinostat
49 Molecularly-Driven Doublet Therapy for Recurrent CNS Malignant Neoplasms Recruiting NCT03434262 Phase 1 Gemcitabine;ribociclib;sonidegib;trametinib
50 Palbociclib Isethionate in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors Recruiting NCT02255461 Phase 1 palbociclib isethionate

Search NIH Clinical Center for Pineoblastoma

Cochrane evidence based reviews: pinealoma

Genetic Tests for Pineoblastoma

Anatomical Context for Pineoblastoma

The Foundational Model of Anatomy Ontology organs/tissues related to Pineoblastoma:

18
The Brain

MalaCards organs/tissues related to Pineoblastoma:

38
Brain, Pineal, Bone, Bone Marrow, Spinal Cord, Liver, Endothelial

Publications for Pineoblastoma

Articles related to Pineoblastoma:

(show top 50) (show all 79)
# Title Authors Year
1
Pineoblastoma-The Experience at St. Jude Children's Research Hospital. ( 28327927 )
2017
2
Evaluation of age-dependent treatment strategies for children and young adults with pineoblastoma: analysis of pooled European Society for Paediatric Oncology (SIOP-E) and US Head Start data. ( 28011926 )
2016
3
MRI-based assessment of the pineal gland in a large population of children aged 0-5A years and comparison with pineoblastoma: part II, the cystic gland. ( 27130617 )
2016
4
MRI-based assessment of the pineal gland in a large population of children aged 0-5A years and comparison with pineoblastoma: part I, the solid gland. ( 27130616 )
2016
5
A rare case of a pineoblastoma with a rhabdomyoblastic component. ( 27775846 )
2016
6
Clinical Reasoning: Left hemiparesis, ataxia, and optic neuritis in a child previously treated for pineoblastoma. ( 27163667 )
2016
7
Isolation and characterization of tumorspheres from a recurrent pineoblastoma patient: Feasibility of a patient-derived xenograft. ( 27277549 )
2016
8
Complete regression of adult pineoblastoma following radiotherapy: A case report and review of the literature. ( 26622845 )
2015
9
Magnetic resonance imaging based morphologic evaluation of the pineal gland for suspected pineoblastoma in retinoblastoma patients and age-matched controls. ( 26671110 )
2015
10
Leptomeningeal metastases in pineoblastoma. ( 26123467 )
2015
11
A Case of Radiation-Induced Osteosarcoma after the Treatment of Pineoblastoma. ( 26605276 )
2015
12
The postirradiation incidence of cavernous angioma is higher in patients with childhood pineoblastoma or primitive neuroectodermal tumors than medulloblastoma. ( 25690449 )
2015
13
Intraosseous Metastasizing of Pineoblastoma into the Anterior Skull Base, Calvarial Bones, and Vertebrae. ( 26858918 )
2015
14
Germ-line and somatic DICER1 mutations in pineoblastoma. ( 25022261 )
2014
15
Clinical Outcomes and Patterns of Failure in Pineoblastoma: A 30-year Single Institution Retrospective Review. ( 25045788 )
2014
16
From a Suspicious Cystic Pineal Gland to Pineoblastoma in a Patient with Familial Unilateral Retinoblastoma. ( 24940935 )
2014
17
Incidence of pineal gland cyst and pineoblastoma in children with retinoblastoma during the chemoreduction era. ( 24238207 )
2013
18
Incidence of pineal gland cyst and pineoblastoma in children with retinoblastoma during the chemoreduction era. ( 23876864 )
2013
19
The long-term postsurgical prognosis of patients with pineoblastoma. ( 21717450 )
2012
20
Donor transmission of pineoblastoma in a two-yr-old male recipient of a multivisceral transplant: a case report. ( 21281415 )
2012
21
Germline DICER1 mutation and associated loss of heterozygosity in a pineoblastoma. ( 22717647 )
2012
22
Contemporary management of pineoblastoma. ( 21801990 )
2011
23
Genome-wide molecular characterization of central nervous system primitive neuroectodermal tumor and pineoblastoma. ( 21798848 )
2011
24
Post-chemotherapy maturation of a pineoblastoma. ( 20224924 )
2010
25
Post-radiation reactive changes in a single vertebral body mimicking metastatic pineoblastoma. ( 19877784 )
2009
26
Response of an adult patient with pineoblastoma to vorinostat and retinoic acid. ( 19506816 )
2009
27
Severe cytomegalic pneumonitis associated with pulmonary aspergillosis in a child with immunosuppression due to chemotherapy for treating pineoblastoma. ( 19287944 )
2009
28
Transformation of a low-grade pineal parenchymal tumour to secondary pineoblastoma. ( 19284482 )
2009
29
Outcome of pediatric pineoblastoma after surgery, radiation and chemotherapy. ( 18415046 )
2008
30
Diffusion-weighted MR images and pineoblastoma: diagnosis and follow-up. ( 18392417 )
2008
31
Childhood pineoblastoma: experiences from the prospective multicenter trials HIT-SKK87, HIT-SKK92 and HIT91. ( 16941074 )
2007
32
Cytogenetics of pineoblastoma: four new cases and a literature review. ( 17011992 )
2006
33
Congenital pineoblastoma and parameningeal rhabdomyosarcoma: concurrent two embryonal tumors in a young infant. ( 16283194 )
2006
34
Osseous metastasis of pineoblastoma: a case report and review of the literature. ( 16078108 )
2005
35
Molecular genetics of supratentorial primitive neuroectodermal tumors and pineoblastoma. ( 16398467 )
2005
36
Management and survival of pineoblastoma: an analysis of 34 adults from the brain tumor registry of Japan. ( 15782004 )
2005
37
Pineal parenchymal tumours: II. On the aggressive behaviour of pineoblastoma in patients with an inherited mutation of the RB1 gene. ( 15214647 )
2004
38
Pathologic quiz case: a 15-year-old girl with an intracranial midline mass. Pineoblastoma, World Health Organization Grade IV. ( 15163221 )
2004
39
Pathology case of the month. Tumor of the pineal region. Pineoblastoma, recurrent. ( 15233382 )
2004
40
Surgical treatment of a mixed pineocytoma/pineoblastoma in a 72-year-old patient. ( 12021888 )
2002
41
Screening for pineoblastoma in patients with retinoblastoma. ( 12470168 )
2002
42
Detection of a pineoblastoma with large central cyst in a young child. ( 11981625 )
2002
43
Vertebral metastases from pineoblastoma. ( 11419982 )
2001
44
Non-resective management of pineoblastoma. ( 11108118 )
2000
45
Neuroradiological characteristics of pineocytoma and pineoblastoma. ( 10952183 )
2000
46
Long-term survival following extra-neural metastasis from a pineoblastoma. ( 11083078 )
2000
47
F-18 FDG PET scan of a metastatic pineoblastoma. ( 10069738 )
1999
48
Pineoblastoma showing unusual ventricular extension in a young adult--case report. ( 10487041 )
1999
49
A new pineoblastoma cell line, PER-480, with der(10)t(10;17), der(16)t(1;16), and enhanced MYC expression in the absence of gene amplification. ( 9428362 )
1998
50
Pineoblastoma presenting in familial adenomatous polyposis (FAP): random association, FAP variant or Turcot syndrome? ( 10070471 )
1998

Variations for Pineoblastoma

ClinVar genetic disease variations for Pineoblastoma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 DICER1 NM_177438.2(DICER1): c.5103C> A (p.Tyr1701Ter) single nucleotide variant Pathogenic rs875989780 GRCh38 Chromosome 14, 95094149: 95094149
2 DICER1 NM_177438.2(DICER1): c.4754C> G (p.Ser1585Ter) single nucleotide variant Pathogenic rs875989779 GRCh37 Chromosome 14, 95562503: 95562503
3 DICER1 NM_177438.2(DICER1): c.4633dupT (p.Ser1545Phefs) duplication Pathogenic rs875989781 GRCh38 Chromosome 14, 95096287: 95096287
4 DICER1 NM_177438.2(DICER1): c.4407_4410delTTCT (p.Ser1470Leufs) deletion Pathogenic rs875989784 GRCh37 Chromosome 14, 95562847: 95562850
5 DICER1 NM_177438.2(DICER1): c.4050+1G> A single nucleotide variant Pathogenic/Likely pathogenic rs875989783 GRCh38 Chromosome 14, 95103345: 95103345
6 DICER1 NM_177438.2(DICER1): c.1498A> T (p.Lys500Ter) single nucleotide variant Pathogenic rs875989782 GRCh38 Chromosome 14, 95117633: 95117633

Expression for Pineoblastoma

Search GEO for disease gene expression data for Pineoblastoma.

Pathways for Pineoblastoma

Pathways related to Pineoblastoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.33 GFAP SAG SYP
2 10.85 GFAP SYP

GO Terms for Pineoblastoma

Cellular components related to Pineoblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.17 AFP ASMT CADPS DICER1 GFAP POU5F1

Biological processes related to Pineoblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to wounding GO:0009611 8.62 GFAP POU5F1

Sources for Pineoblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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