MCID: PNC056
MIFTS: 39

Pineocytoma malady

Categories: Rare diseases, Neuronal diseases, Endocrine diseases, Cancer diseases

Aliases & Classifications for Pineocytoma

Aliases & Descriptions for Pineocytoma:

Name: Pineocytoma 50 56 52 69
Tumor of the Pineal Region 69
Pineal Gland Neoplasm 69
Pinealocytoma 50
Pinealoma 50

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Orphanet 56 ORPHA251912
UMLS via Orphanet 70 C0917890
ICD10 via Orphanet 34 D44.5

Summaries for Pineocytoma

NIH Rare Diseases : 50 a pineocytoma is a tumor of the pineal gland, a small organ in the brain that makes melatonin (a sleep-regulating hormone). pineocytomas most often occur in adults as a solid mass, although they may appear to have fluid-filled (cystic) spaces on images of the brain. signs and symptoms of pineocytomas include headaches, nausea, hydrocephalus, vision abnormalities, and parinaud syndrome. pineocytomas are usually slow-growing and rarely spread to other parts of the body. treatment includes surgery to remove the pineocytoma; most of these tumors do not regrow (recur) after surgery. last updated: 11/13/2014

MalaCards based summary : Pineocytoma, also known as tumor of the pineal region, is related to pineoblastoma and pineal gland cancer. An important gene associated with Pineocytoma is SYP (Synaptophysin), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Etoposide and Melphalan have been mentioned in the context of this disorder. Affiliated tissues include pineal, brain and spinal cord.

Wikipedia : 71 Pineocytoma, also known as a pinealocytoma, is a benign, slowly growing tumor of the pineal gland.... more...

Related Diseases for Pineocytoma

Diseases related to Pineocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
id Related Disease Score Top Affiliating Genes
1 pineoblastoma 32.1 GFAP SYP
2 pineal gland cancer 10.8
3 conjunctivitis 10.3 SYP TUBB3
4 diabetes hypogonadism deafness mental retardation 10.3 GFAP SYP
5 papillary tumor of the pineal region 10.3 GFAP SYP
6 intrahepatic bile duct adenoma 10.3 GFAP SYP
7 pilocytic astrocytoma of cerebellum 10.3 GFAP SYP
8 children's interstitial lung disease 10.3 GFAP SYP
9 corneal intraepithelial neoplasm 10.3 S100B SYP
10 hypoparathyroidism-intellectual disability-dysmorphism syndrome 10.3 S100B SYP
11 cervical benign neoplasm 10.3 GFAP SYP
12 infiltrating renal pelvis transitional cell carcinoma 10.3 ENO2 SYP
13 myxopapillary ependymoma 10.3 GFAP SYP
14 skeletal-extraskeletal angiomatosis 10.3 ENO2 SYP
15 epidermal appendage tumor 10.3 GFAP SYP
16 monkeypox 10.3 S100B SYP
17 nemaline myopathy 10.3 GFAP TUBB3
18 glomus tumor 10.3 ENO2 SYP
19 movement disease 10.3 S100B SYP
20 paternal uniparental disomy of chromosome 1 10.3 GFAP SYP
21 cerebral folate receptor alpha deficiency 10.3 GFAP SYP
22 pemphigus foliaceus 10.3 ENO2 SYP
23 vulvar benign neoplasm 10.3 GFAP SYP
24 autosomal recessive stickler syndrome 10.3 ENO2 SYP
25 ampullary signet ring cell adenocarcinoma 10.3 ENO2 SYP
26 male reproductive system disease 10.3 GFAP SYP
27 early-onset parkinson disease 10.3 S100B SYP
28 bronchial mucus gland adenoma 10.3 GFAP S100B
29 bone deterioration disease 10.3 S100B SYP
30 pleomorphic xanthoastrocytoma 10.3 GFAP SYP
31 spleen angiosarcoma 10.3 GFAP S100B
32 central neurocytoma 10.3 GFAP SYP
33 ovarian cystadenoma 10.3 GFAP S100B
34 mast-cell sarcoma 10.3 GFAP SYP
35 olfactory neuroblastoma 10.3 GFAP SYP
36 biliary papillomatosis 10.3 GFAP S100B
37 benign schwannoma 10.3 ENO2 S100B
38 porokeratosis 10.3 GFAP S100B
39 sternum cancer 10.3 GFAP S100B
40 thrombophlebitis 10.2 ENO2 GFAP
41 rectum leiomyoma 10.2 ENO2 SYP
42 vulvar squamous papilloma 10.2 GFAP S100B
43 gallbladder pleomorphic giant cell adenocarcinoma 10.2 ENO2 SYP
44 adult epithelioid sarcoma 10.2 ENO2 SYP
45 thymoma 10.2 ENO2 SYP
46 peroneal nerve paralysis 10.2 CHGA SYP
47 thoracic benign neoplasm 10.2 ENO2 SYP
48 jejunal somatostatinoma 10.2 ENO2 GFAP
49 non specific chronic endometritis 10.2 CHGA SYP
50 extrahepatic biliary papillomatosis 10.2 CHGA SYP

Graphical network of the top 20 diseases related to Pineocytoma:



Diseases related to Pineocytoma

Symptoms & Phenotypes for Pineocytoma

Drugs & Therapeutics for Pineocytoma

Drugs for Pineocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 177)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 2, Phase 3,Phase 1 33419-42-0 36462
2
Melphalan Approved Phase 2, Phase 3,Phase 1 148-82-3 4053 460612
3
Carboplatin Approved Phase 2, Phase 3, Phase 1 41575-94-4 10339178 498142 38904
4
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
5
Thiotepa Approved Phase 2, Phase 3 52-24-4 5453
6
Donepezil Approved Phase 3,Phase 2 120014-06-4 3152
7
Lenograstim Approved Phase 3,Phase 2,Phase 1 135968-09-1
8
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
9
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
10
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
11
Isotretinoin Approved Phase 3 4759-48-2 5538 5282379
12 Dermatologic Agents Phase 3,Phase 2,Phase 1
13 Etoposide phosphate Phase 2, Phase 3,Phase 1
14 pancreatic polypeptide Phase 3,Phase 1
15 Analgesics Phase 3,Phase 2,Phase 1
16 Alkylating Agents Phase 3,Phase 2,Phase 1
17 Cholinergic Agents Phase 3,Phase 2
18 Adjuvants, Anesthesia Phase 3
19 Cholinesterase Inhibitors Phase 3,Phase 2
20 Narcotics Phase 3
21 Neurotransmitter Agents Phase 3,Phase 2
22 Nootropic Agents Phase 3,Phase 2
23 Analgesics, Opioid Phase 3
24 Anesthetics Phase 3
25 Anesthetics, General Phase 3
26 Anesthetics, Intravenous Phase 3
27 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
28 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
29 Liver Extracts Phase 3,Phase 1,Phase 2
30 Antimitotic Agents Phase 3,Phase 1
31 Antirheumatic Agents Phase 3,Phase 2,Phase 1
32 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
33 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
34 Central Nervous System Depressants Phase 3,Phase 2
35 Adjuvants, Immunologic Phase 3
36 Cola Nutraceutical Phase 3,Phase 1
37
Irinotecan Approved, Investigational Phase 2,Phase 1 97682-44-5, 100286-90-6 60838
38 Piracetam Approved Phase 2 7491-74-9
39
Miconazole Approved, Investigational, Vet_approved Phase 2,Phase 1 22916-47-8 4189
40
Dacarbazine Approved, Investigational Phase 1, Phase 2 4342-03-4 5351166
41
Everolimus Approved Phase 2,Phase 1 159351-69-6 6442177
42
Temozolomide Approved, Investigational Phase 2,Phase 1 85622-93-1 5394
43
Pregabalin Approved, Illicit, Investigational Phase 2 148553-50-8 5486971
44
Bevacizumab Approved, Investigational Phase 2 216974-75-3
45
Sirolimus Approved, Investigational Phase 2,Phase 1 53123-88-9 5284616 6436030 46835353
46
Ethanol Approved Phase 2 64-17-5 702
47
Mannitol Approved, Investigational Phase 1, Phase 2 69-65-8 453 6251
48
Dasatinib Approved, Investigational Phase 2,Phase 1 302962-49-8 3062316
49
Mechlorethamine Approved Phase 1, Phase 2 51-75-2 4033
50
Benzocaine Approved Phase 2 1994-09-7, 94-09-7 2337

Interventional clinical trials:

(show top 50) (show all 61)
id Name Status NCT ID Phase
1 Stem Cell Transplant for High Risk Central Nervous System (CNS) Tumors Unknown status NCT00179803 Phase 2, Phase 3
2 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
3 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3
4 Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma Recruiting NCT00392327 Phase 3
5 Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With Cancer Active, not recruiting NCT01987596 Phase 3
6 Combination Chemotherapy, Surgery or Radiation Therapy, and Peripheral Stem Cell Transplant in Treating Patients With Recurrent Medulloblastoma or Primitive Neuroectodermal and Pineal Tumors Completed NCT00025077 Phase 2
7 Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer Completed NCT00492089 Phase 2
8 Levetiracetam or Pregabalin in Treating Seizures in Patients Undergoing Chemotherapy and/or Radiation Therapy For Primary Brain Tumors Completed NCT00629889 Phase 2
9 Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor Completed NCT00070161 Phase 2
10 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Tumors Completed NCT00003461 Phase 1, Phase 2
11 Prospective Pilot Trial to Assess a Multimodal Molecular Targeted Therapy in Children, Adolescent and Young Adults With Relapsed or Refractory High-grade Pineoblastoma Recruiting NCT02596828 Phase 2
12 Plerixafor After Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed High Grade Glioma Recruiting NCT01977677 Phase 1, Phase 2
13 Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors Recruiting NCT00983398 Phase 1, Phase 2
14 Proton Beam Radiation Therapy in Treating Patients With Low Grade Gliomas Active, not recruiting NCT01024907 Phase 1, Phase 2
15 Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal Tumors Active, not recruiting NCT01217437 Phase 2
16 Proton Beam Radiation Therapy in Treating Young Patients Who Have Undergone Biopsy or Surgery for Medulloblastoma or Pineoblastoma Active, not recruiting NCT00105560 Phase 2
17 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2
18 Phase II Pediatric Study With Dabrafenib in HGG Patients Not yet recruiting NCT02684058 Phase 2
19 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1
20 Stereotactic Radiosurgery in Treating Patients With Brain Tumors Completed NCT00019578 Phase 1
21 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma Completed NCT01119599 Phase 1
22 Bortezomib and Temozolomide in Treating Patients With Brain Tumors or Other Solid Tumors That Have Not Responded to Treatment Completed NCT00544284 Phase 1
23 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1
24 Carboxyamidotriazole and Paclitaxel in Treating Patients With Advanced Solid Tumors or Refractory Lymphomas Completed NCT00019019 Phase 1
25 Calcitriol Plus Carboplatin in Treating Patients With Advanced Solid Tumors Completed NCT00008086 Phase 1
26 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
27 Liposomal Doxorubicin in Treating Children With Refractory Solid Tumors Completed NCT00019630 Phase 1
28 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1
29 Radiolabeled Monoclonal Antibody Therapy After Radiation Therapy in Treating Patients With Primary Brain Tumors Completed NCT00003484 Phase 1
30 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1
31 PTC299 in Treating Young Patients With Refractory or Recurrent Primary Central Nervous System Tumors Completed NCT01158300 Phase 1
32 Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors Completed NCT01076530 Phase 1
33 Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma Completed NCT00994500 Phase 1
34 ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors Completed NCT00946335 Phase 1
35 AZD2171 in Treating Young Patients With Recurrent, Progressive, or Refractory Primary CNS Tumors Completed NCT00326664 Phase 1
36 Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors Completed NCT00100880 Phase 1
37 Cilengitide in Treating Children With Refractory Primary Brain Tumors Completed NCT00063973 Phase 1
38 Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors Completed NCT00052780 Phase 1
39 Entinostat in Treating Pediatric Patients With Recurrent or Refractory Solid Tumors Recruiting NCT02780804 Phase 1
40 Palbociclib Isethionate in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors Recruiting NCT02255461 Phase 1
41 Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Newly Diagnosed Brain Tumors Terminated NCT00110032 Phase 1
42 Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia Terminated NCT01088763 Phase 1
43 A Phase I Study of IMC-A12 in Combination With Temsirolimus in Pediatric Patients With Recurrent or Refractory Solid Tumors Withdrawn NCT01182883 Phase 1
44 Study of Genes and Environment in Patients With Cancer in East Anglia, Trent, or West Midlands Regions of the United Kingdom Unknown status NCT00757614
45 Morphological Analysis of the Pineal Gland in Pediatric Retinoblastoma Patients Using Magnetic Resonance Imaging Completed NCT01884194
46 Study of Blood and Cheek Cell Samples From Patients With Glioma Completed NCT01009307
47 Study of Tissue Samples From Patients With Glioma or Other Brain Tumors Completed NCT00967200
48 A Feasibility, Dose-Escalation Study Using Intracerebral Microdialysis to Assess the Neuropharmacodynamics of Temsirolimus in Patients With Primary or Metastatic Brain Tumors Completed NCT00784914
49 Changes in Semen or Sperm Caused by Temozolomide in Patients With Newly Diagnosed, Progressive, or Recurrent Primary Malignant Brain Tumors Completed NCT00499798
50 Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders Completed NCT00255671

Search NIH Clinical Center for Pineocytoma

Genetic Tests for Pineocytoma

Anatomical Context for Pineocytoma

MalaCards organs/tissues related to Pineocytoma:

39
Pineal, Brain, Spinal Cord

Publications for Pineocytoma

Articles related to Pineocytoma:

(show all 46)
id Title Authors Year
1
Progressive supranuclear palsy motor phenotype in a patient with pineocytoma. ( 27432179 )
2016
2
Familial pineocytoma. ( 22699425 )
2012
3
Sleep disturbance after pinealectomy in patients with pineocytoma WHOA^I. ( 22706841 )
2012
4
Pineocytoma with diffuse dissemination to the leptomeninges. ( 22355508 )
2011
5
Pineocytoma in a lowland anoa (Bubalus depressicornis). ( 20961555 )
2011
6
Pleomorphic pineocytoma associated with normal pineal parenchyma: report of a case in a 70-year-old man. ( 20573029 )
2011
7
Contemporary management of pineocytoma. ( 21801989 )
2011
8
Factors influencing overall survival rates for patients with pineocytoma. ( 20461445 )
2010
9
Tumor control after surgery and radiotherapy for pineocytoma. ( 20136388 )
2010
10
In-111 pentetreotide in recurrent pineocytoma. ( 19352270 )
2009
11
Pineocytoma and pineal parenchymal tumors of intermediate differentiation presenting cytologic pleomorphism: a multicenter study. ( 18371183 )
2008
12
Pineocytoma mimicking a pineal cyst on imaging: true diagnostic dilemma or a case of incomplete imaging? ( 17925371 )
2008
13
Papillary pineocytoma in child: a case report. ( 17690754 )
2007
14
Pineal parenchymal tumours: I. Pineocytoma: a tumour responsive to platinum-based chemotherapy. ( 15214646 )
2004
15
Pineal epidermoid coinciding with pineocytoma. ( 14505106 )
2003
16
Surgical treatment of a mixed pineocytoma/pineoblastoma in a 72-year-old patient. ( 12021888 )
2002
17
Dorsal midbrain syndrome secondary to a pineocytoma. ( 11338448 )
2001
18
Cytogenetic and ultrastructural study of a pineocytoma case report. ( 11083076 )
2000
19
Neuroradiological characteristics of pineocytoma and pineoblastoma. ( 10952183 )
2000
20
Case report: pineocytoma in a male Fischer 344 rat. ( 9547871 )
1998
21
Immunohistochemical, ultrastructural, biochemical and in vitro studies of a pineocytoma. ( 9600600 )
1998
22
Characteristic patterns of Tl-201 chloride and Tc-99m MIBI uptake in a pineocytoma. ( 9814568 )
1998
23
Pineocytoma with massive intratumoral hemorrhage after ventriculoperitoneal shunt--case report. ( 9465590 )
1997
24
Clinicopathological study on pineocytoma. ( 7795727 )
1995
25
Metastatic pineocytoma of the spinal cord after long-term dormancy. ( 7866570 )
1994
26
Pleomorphic pineocytoma with extensive neuronal differentiation: report of two cases. ( 7847074 )
1994
27
Acquired double elevator palsy in a child with a pineocytoma. ( 7977612 )
1994
28
Chromosomal abnormalities in a pineocytoma. ( 8281527 )
1993
29
Pineocytoma with intratumoral hemorrhage following ventriculoperitoneal shunt--case report. ( 7512231 )
1993
30
Concurrent uveoretinitis and pineocytoma in a child suggests a causal relationship. ( 1420067 )
1992
31
Cystic pineocytoma--case report. ( 1377802 )
1992
32
Immunohistochemical characterization of pineocytomas. ( 1473313 )
1992
33
Cytogenetic study of a pineocytoma. ( 1486561 )
1992
34
Spontaneous malignant pineocytoma in a female Wistar rat. ( 1832044 )
1991
35
Papillary pineocytoma. Case report. ( 2352014 )
1990
36
Pineocytoma with neuronal differentiation--case report. ( 1694277 )
1990
37
MR imaging of pineocytoma: report of two cases. ( 2105605 )
1990
38
Responses of pineocytoma to radiation therapy and chemotherapy--report of two cases. ( 2480541 )
1989
39
Pineocytoma with neuronal differentiation demonstrated immunocytochemically. A case report. ( 3111171 )
1987
40
S-antigen-like immunoreactivity in a human pineocytoma. ( 3515828 )
1986
41
Pineocytoma. Observation of an autopsy case by electron microscopy and cell markers. ( 6485805 )
1984
42
Malignant pineocytoma with prominent papillary features. ( 7116304 )
1982
43
The separation of pineocytoma from pineoblastoma. ( 6986979 )
1980
44
Pineocytoma with astrocytomatous differentiation. ( 438866 )
1979
45
Experimental pineocytoma of the Syrian hamster induced by a human papovavirus (JC). A light and electron microscopic study. ( 941681 )
1976
46
Gangliogliomatous differentiation in a pineocytoma. ( 4101025 )
1970

Variations for Pineocytoma

Expression for Pineocytoma

Search GEO for disease gene expression data for Pineocytoma.

Pathways for Pineocytoma

GO Terms for Pineocytoma

Cellular components related to Pineocytoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 photoreceptor inner segment GO:0001917 8.8 ENO2 RHO SAG

Biological processes related to Pineocytoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of rhodopsin mediated signaling pathway GO:0022400 9.37 RHO SAG
2 response to light stimulus GO:0009416 9.32 AANAT RHO
3 regulation of neuronal synaptic plasticity GO:0048168 9.26 S100B SYP
4 rhodopsin mediated signaling pathway GO:0016056 9.16 RHO SAG
5 indolalkylamine biosynthetic process GO:0046219 8.96 AANAT ASMT
6 melatonin biosynthetic process GO:0030187 8.62 AANAT ASMT

Sources for Pineocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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