MCID: PNC056
MIFTS: 43

Pineocytoma malady

Rare diseases, Neuronal diseases, Cancer diseases categories

Summaries for Pineocytoma

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NIH Rare Diseases:42 A pineocytoma is a tumor of the pineal gland, a small organ in the brain that makes melatonin (a sleep-regulating hormone). pineocytomas most often occur in adults as a solid mass, although they may appear to have fluid-filled (cystic) spaces on images of the brain. signs and symptoms of pineocytomas include headaches, nausea, hydrocephalus, vision abnormalities, and parinaud syndrome. pineocytomas are usually slow-growing and rarely spread to other parts of the body. treatment includes surgery to remove the pineocytoma; most of these tumors do not regrow (recur) after surgery. last updated: 11/13/2014

MalaCards based summary: Pineocytoma, also known as pinealocytoma, is related to pineoblastoma and retinoblastoma. An important gene associated with Pineocytoma is ASMT (acetylserotonin O-methyltransferase), and among its related pathways are The phototransduction cascade and tryptophan utilization II. The compounds reticulin and smcc have been mentioned in the context of this disorder. Affiliated tissues include pineal, brain and spinal cord, and related mouse phenotype nervous system.

Wikipedia:64 Pineocytoma, also known as a pinealocytoma, is a benign, slowly growing tumor of the pineal gland.... more...

Aliases & Classifications for Pineocytoma

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Sources:
42NIH Rare Diseases, 44Novoseek, 48Orphanet, 61UMLS, 62UMLS via Orphanet
See all sources

Pineocytoma, Aliases & Descriptions:

Name: Pineocytoma 42 44 48 61
Pinealocytoma 42 61
 
Pinealoma 42 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


External Ids:

UMLS via Orphanet62 C0917890

Related Diseases for Pineocytoma

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Diseases related to Pineocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 104)
idRelated DiseaseScoreTop Affiliating Genes
1pineoblastoma30.6ASMT, SYP, SAG, GFAP
2retinoblastoma29.2ENO2, SYP, AANAT, ASMT, SAG, LINC01194
3melanotic neuroectodermal tumor10.5SYP
4dysembryoplastic neuroepithelial tumor10.5SYP
5giant cell glioblastoma10.5GFAP
6somatostatinoma10.5CHGA
7cerebral primitive neuroectodermal tumor10.5ENO2
8paraganglioma10.5SYP
9epulis10.5ENO2
10alexander disease10.5GFAP
11choroid plexus papilloma10.5GFAP
12secondary progressive multiple sclerosis10.4MBP
13oguchi disease 110.4SAG, RHO
14acute disseminated encephalomyelitis10.4MBP
15pancreatic islet cell tumors10.4CHGA, SYP
16subependymal giant cell astrocytoma10.4SYP, S100B
17endocrine gland cancer10.4CHGA, SYP
18retinitis10.4RHO, SAG
19spiradenoma10.3RHO, SAG
20binswanger's disease10.3GFAP, SYP
21night blindness10.3RHO, SAG
22neuroblastoma10.3SYP, ENO2
23myxopapillary ependymoma10.3GFAP, S100B
24gemistocytic astrocytoma10.3GFAP, S100B
25anaplastic ependymoma10.3GFAP, S100B
26amyotrophic lateral sclerosis type 1410.3SYP, GFAP
27sertoli cell tumor10.3SYP, ENO2
28syringoma10.3S100B, GFAP
29myoepithelioma10.3GFAP, S100B
30neuroectodermal tumor10.3ENO2, SYP
31neuronitis10.3
32glucagonoma10.3ENO2, CHGA
33neurilemmoma10.3ENO2, GFAP
34chordoma10.3GFAP, S100B
35germinoma10.3
36creutzfeldt-jakob disease10.2ENO2, S100B
37pleomorphic adenoma10.2GFAP, S100B
38neonatal hypoxic and ischemic brain injury10.2MBP, ENO2
39retinal degeneration10.2GFAP, SAG, RHO
40central neurocytoma10.2SYP, CHGA, GFAP
41neurofibromatosis10.2S100B, ENO2
42papillary ependymoma10.2GFAP, SYP, S100B
43adrenocortical carcinoma10.2SYP, CHGA
44merkel cell carcinoma10.2SYP, ENO2, CHGA
45pilocytic astrocytoma10.2S100B, SYP, GFAP
46tubular adenocarcinoma10.2ENO2, CHGA, SYP
47gastrinoma10.2ENO2, SYP, CHGA
48large cell carcinoma10.2CHGA, SYP, ENO2
49olfactory neuroblastoma10.2SYP, S100B, ENO2
50tuberous sclerosis10.2S100B, SYP, GFAP

Graphical network of the top 20 diseases related to Pineocytoma:



Diseases related to pineocytoma

Symptoms for Pineocytoma

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Drugs & Therapeutics for Pineocytoma

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Drug clinical trials:

Search ClinicalTrials for Pineocytoma

Search NIH Clinical Center for Pineocytoma

Genetic Tests for Pineocytoma

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Anatomical Context for Pineocytoma

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MalaCards organs/tissues related to Pineocytoma:

32
Pineal, Brain, Spinal cord

Animal Models for Pineocytoma or affiliated genes

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MGI Mouse Phenotypes related to Pineocytoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.6ENO2, MBP, RHO, SYP, AANAT, SAG

Publications for Pineocytoma

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Articles related to Pineocytoma:

(show all 45)
idTitleAuthorsYear
1
Sleep disturbance after pinealectomy in patients with pineocytoma WHOA^I. (22706841)
2012
2
Familial pineocytoma. (22699425)
2012
3
Pineocytoma with diffuse dissemination to the leptomeninges. (22355508)
2011
4
Pineocytoma in a lowland anoa (Bubalus depressicornis). (20961555)
2011
5
Contemporary management of pineocytoma. (21801989)
2011
6
Pleomorphic pineocytoma associated with normal pineal parenchyma: report of a case in a 70-year-old man. (20573029)
2011
7
Factors influencing overall survival rates for patients with pineocytoma. (20461445)
2010
8
Tumor control after surgery and radiotherapy for pineocytoma. (20136388)
2010
9
In-111 pentetreotide in recurrent pineocytoma. (19352270)
2009
10
Pineocytoma mimicking a pineal cyst on imaging: true diagnostic dilemma or a case of incomplete imaging? (17925371)
2008
11
Pineocytoma and pineal parenchymal tumors of intermediate differentiation presenting cytologic pleomorphism: a multicenter study. (18371183)
2008
12
Papillary pineocytoma in child: a case report. (17690754)
2007
13
Pineal parenchymal tumours: I. Pineocytoma: a tumour responsive to platinum-based chemotherapy. (15214646)
2004
14
Pineal epidermoid coinciding with pineocytoma. (14505106)
2003
15
Surgical treatment of a mixed pineocytoma/pineoblastoma in a 72-year-old patient. (12021888)
2002
16
Dorsal midbrain syndrome secondary to a pineocytoma. (11338448)
2001
17
Neuroradiological characteristics of pineocytoma and pineoblastoma. (10952183)
2000
18
Cytogenetic and ultrastructural study of a pineocytoma case report. (11083076)
2000
19
Immunohistochemical, ultrastructural, biochemical and in vitro studies of a pineocytoma. (9600600)
1998
20
Characteristic patterns of Tl-201 chloride and Tc-99m MIBI uptake in a pineocytoma. (9814568)
1998
21
Case report: pineocytoma in a male Fischer 344 rat. (9547871)
1998
22
Pineocytoma with massive intratumoral hemorrhage after ventriculoperitoneal shunt--case report. (9465590)
1997
23
Clinicopathological study on pineocytoma. (7795727)
1995
24
Acquired double elevator palsy in a child with a pineocytoma. (7977612)
1994
25
Pleomorphic pineocytoma with extensive neuronal differentiation: report of two cases. (7847074)
1994
26
Metastatic pineocytoma of the spinal cord after long-term dormancy. (7866570)
1994
27
Pineocytoma with intratumoral hemorrhage following ventriculoperitoneal shunt--case report. (7512231)
1993
28
Chromosomal abnormalities in a pineocytoma. (8281527)
1993
29
Concurrent uveoretinitis and pineocytoma in a child suggests a causal relationship. (1420067)
1992
30
Cystic pineocytoma--case report. (1377802)
1992
31
Immunohistochemical characterization of pineocytomas. (1473313)
1992
32
Cytogenetic study of a pineocytoma. (1486561)
1992
33
Spontaneous malignant pineocytoma in a female Wistar rat. (1832044)
1991
34
MR imaging of pineocytoma: report of two cases. (2105605)
1990
35
Pineocytoma with neuronal differentiation--case report. (1694277)
1990
36
Papillary pineocytoma. Case report. (2352014)
1990
37
Responses of pineocytoma to radiation therapy and chemotherapy--report of two cases. (2480541)
1989
38
Pineocytoma with neuronal differentiation demonstrated immunocytochemically. A case report. (3111171)
1987
39
S-antigen-like immunoreactivity in a human pineocytoma. (3515828)
1986
40
Pineocytoma. Observation of an autopsy case by electron microscopy and cell markers. (6485805)
1984
41
Malignant pineocytoma with prominent papillary features. (7116304)
1982
42
The separation of pineocytoma from pineoblastoma. (6986979)
1980
43
Pineocytoma with astrocytomatous differentiation. (438866)
1979
44
Experimental pineocytoma of the Syrian hamster induced by a human papovavirus (JC). A light and electron microscopic study. (941681)
1976
45
Gangliogliomatous differentiation in a pineocytoma. (4101025)
1970

Variations for Pineocytoma

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Expression for genes affiliated with Pineocytoma

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Expression patterns in normal tissues for genes affiliated with Pineocytoma

Search GEO for disease gene expression data for Pineocytoma.

Pathways for genes affiliated with Pineocytoma

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Pathways related to Pineocytoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9RHO, SAG
2
Show member pathways
tryptophan degradation X (mammalian, via tryptamine)37
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA37
tryptophan degradation37
glutaryl-CoA degradation37
serotonin degradation37
NAD de novo biosynthesis37
superpathway of melatonin degradation37
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde37
tryptophan utilization I37
melatonin degradation I37
9.8AANAT, ASMT
3
Show member pathways
catecholamine biosynthesis37
9.8ASMT, AANAT
4
Show member pathways
serotonin and melatonin biosynthesis37
9.8AANAT, ASMT
5
Show member pathways
9.7S100B, GFAP
68.2ENO2, S100B, RHO, SYP, SAG, GFAP

Compounds for genes affiliated with Pineocytoma

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Compounds related to Pineocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 112)
idCompoundScoreTop Affiliating Genes
1reticulin449.6GFAP, SYP, S100B
2smcc449.5CHGA, SYP, ENO2
32,3-cyclic nucleotide449.4MBP, S100B, GFAP
4edss449.3S100B, MBP, ENO2
55-hydroxyindoleacetic acid44 2510.2ENO2, ASMT, CHGA
6homovanillic acid44 2510.2ENO2, CHGA, GFAP
7l-amino acid449.2CHGA, SYP, S100B, ENO2
8catecholamine449.0ENO2, S100B, SYP, CHGA
9guanine44 25 1210.9CHGA, SAG, SYP, RHO, ENO2
10phospholipid448.9MBP, S100B, RHO, SYP, SAG
11ganglioside448.9GFAP, SYP, MBP, ENO2
12s 100448.9ENO2, S100B, SYP, CHGA, GFAP
13amine448.8CHGA, AANAT, SYP, RHO, ENO2
14hematoxylin448.8GFAP, CHGA, SYP, S100B, ENO2
15acth448.8GFAP, CHGA, SYP, S100B, ENO2
16hydrogen44 259.8CHGA, SAG, AANAT, SYP, RHO, S100B
17bromodeoxyuridine448.6GFAP, CHGA, S100B, ENO2
18choline44 25 1210.6GFAP, SYP, S100B, MBP, ENO2
19glycogen44 259.6GFAP, CHGA, SYP, S100B, ENO2
20dbc-amp448.5GFAP, ASMT, AANAT, SYP, S100B, ENO2
21cyclic amp44 259.4GFAP, CHGA, SAG, ASMT, AANAT, SYP
22formaldehyde44 259.3GFAP, CHGA, SYP, S100B, MBP, ENO2
23aspartate448.3GFAP, SAG, RHO, S100B, MBP, ENO2
24adenylate448.2GFAP, CHGA, SAG, S100B, MBP, ENO2
25norepinephrine44 25 1210.2CHGA, AANAT, SYP, S100B, MBP, ENO2
26creatinine448.2GFAP, CHGA, SYP, S100B, MBP, ENO2
275-hydroxytryptamine448.2GFAP, CHGA, SAG, ASMT, AANAT, SYP
28threonine448.2GFAP, SAG, AANAT, RHO, S100B, MBP
29dexamethasone44 50 29 1211.1GFAP, CHGA, AANAT, SYP, S100B, ENO2
30leucine448.1GFAP, SAG, AANAT, SYP, RHO, S100B
31glutamine448.1GFAP, SAG, SYP, RHO, S100B, MBP
32gaba448.0GFAP, CHGA, SYP, RHO, S100B, MBP
33acetylcholine44 50 29 25 1212.0GFAP, CHGA, SYP, RHO, S100B, MBP
34lactate447.9GFAP, CHGA, S100B, MBP, ENO2
35progesterone44 29 60 25 1211.9GFAP, LINC01194, CHGA, SYP, S100B, ENO2
36silver447.9GFAP, LINC01194, CHGA, SYP, MBP, ENO2
37testosterone44 60 25 1210.9GFAP, LINC01194, CHGA, SYP, S100B, ENO2
38dopamine44 29 25 1210.8GFAP, CHGA, SAG, AANAT, SYP, RHO
39thymidine44 258.7ENO2, MBP, S100B, LINC01194, GFAP
40glutamate447.7GFAP, CHGA, SAG, SYP, RHO, S100B
41lipid447.7GFAP, CHGA, SAG, SYP, RHO, S100B
42vegf447.7GFAP, LINC01194, CHGA, SYP, RHO, S100B
43tyrosine447.4GFAP, CHGA, SAG, AANAT, SYP, S100B
44estrogen447.4GFAP, LINC01194, CHGA, SYP, S100B, MBP
45cysteine447.3GFAP, LINC01194, CHGA, AANAT, SYP, RHO
46paraffin447.2GFAP, LINC01194, CHGA, SAG, SYP, S100B
47retinoic acid44 258.2GFAP, LINC01194, CHGA, SYP, RHO, S100B
48alanine447.1GFAP, LINC01194, SAG, AANAT, RHO, S100B
49forskolin44 50 129.0GFAP, LINC01194, CHGA, AANAT, SYP, S100B
50serine447.0GFAP, LINC01194, CHGA, SAG, AANAT, SYP

GO Terms for genes affiliated with Pineocytoma

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Cellular components related to Pineocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1photoreceptor inner segmentGO:0019179.6ENO2, RHO

Biological processes related to Pineocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1rhodopsin mediated signaling pathwayGO:0160569.9RHO, SAG
2melatonin biosynthetic processGO:0301879.9AANAT, ASMT
3indolalkylamine biosynthetic processGO:0462199.8AANAT, ASMT
4regulation of neuronal synaptic plasticityGO:0481689.8S100B, SYP
5long-term synaptic potentiationGO:0602919.6GFAP, S100B
6regulation of rhodopsin mediated signaling pathwayGO:0224009.6RHO, SAG

Products for genes affiliated with Pineocytoma

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Sources for Pineocytoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet