MCID: PNC056
MIFTS: 37

Pineocytoma malady

Neuronal diseases, Cancer diseases, Endocrine diseases categories

Summaries for Pineocytoma

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 A pineocytoma is a tumor of the pineal gland, a small organ in the brain that makes melatonin, a hormone which regulates sleep.  pineocytomas most often occur in adults as a solid mass, though it may appear to have fluid-filled (cystic) spaces on images of the brain.  pineocytomas are usually slow-growing and do not usually spread to other parts of the body.  treatment includes surgery to remove the pineocytoma; most of these tumors do not regrow (recur) after surgery. last updated: 12/20/2011

MalaCards: Pineocytoma, also known as pineal gland neoplasm, is related to pineoblastoma and retinoblastoma. An important gene associated with Pineocytoma is ASMT (acetylserotonin O-methyltransferase), and among its related pathways are Regulation of thyroid hormone activity and Neuroscience. The compounds estrogen and guanine have been mentioned in the context of this disorder. Affiliated tissues include pineal and brain.

Wikipedia:63 Pineocytoma, also known as a pinealocytoma, is a benign, slowly growing tumor of the pineal gland.... more...

Aliases & Classifications for Pineocytoma

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42NIH Rare Diseases, 44Novoseek, 48Orphanet, 60UMLS, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases, Endocrine diseases


Aliases & Descriptions:

pineocytoma 42 44 48 60
pineal gland neoplasm 60
pinealocytoma 42
pinealoma 42


External Ids:

SNOMED-CT via Orphanet57 89096009, 255045009

Related Diseases for Pineocytoma

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17GeneCards, 18GeneDecks
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Diseases related to Pineocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1pineoblastoma30.3ASMT, GFAP, SYP, SAG
2retinoblastoma30.1SAG, CT49, RHO, SYP, GFAP, AANAT
3neuronitis10.2
4panhypopituitarism10.1
5pineal parenchymal tumor of intermediate differentiation10.0
6melanotic neuroectodermal tumor10.0SYP
7rhabdoid tumor10.0SYP
8dysembryoplastic neuroepithelial tumor10.0SYP
9papilloma10.0CT49
10malignant mesothelioma10.0CT49
11medulloepithelioma10.0SYP
12phaeochromocytoma10.0CHGA
13cerebral primitive neuroectodermal tumor10.0ENO2
14leiomyoma10.0S100B
15stroke, ischemic10.0S100B
16pick's disease10.0CHGA
17giant cell glioblastoma10.0GFAP
18epulis10.0ENO2
19somatostatinoma10.0CHGA
20glomus tumor10.0SYP
21gliosarcoma10.0GFAP
22glaucoma10.0MBP
23optic neuritis10.0MBP
24retinal detachment10.0GFAP
25breast cancer10.0MBP
26neuropathy10.0MBP
27down syndrome10.0S100B
28neuritis10.0MBP
29choroid plexus papilloma10.0GFAP
30retinitis10.0SAG, RHO
31acute disseminated encephalomyelitis10.0MBP
32subependymal giant cell astrocytoma10.0S100B, SYP
33diabetic retinopathy10.0RHO, SAG
34oguchi disease 110.0SAG, RHO
35neuroblastoma10.0ENO2, SYP
36pituitary tumors10.0CHGA
37gastrointestinal stromal tumor10.0ENO2, S100B
38dementia10.0GFAP, SYP
39endocrine gland cancer10.0SYP, CHGA
40leiomyosarcoma10.0ENO2, S100B
41chorioretinitis10.0SAG
42aids dementia complex10.0MBP
43binswanger's disease10.0GFAP, SYP
44chondrosarcoma10.0S100B, ENO2
45neuromyelitis optica10.0MBP
46amyotrophic lateral sclerosis10.0GFAP, SYP
47neuroepithelioma10.0SYP, ENO2
48sarcoma10.0ENO2, S100B
49myxopapillary ependymoma10.0S100B, GFAP
50uveitis10.0SAG, RHO

Graphical network of the top 20 diseases related to Pineocytoma:



Diseases related to pineocytoma

Clinical Features for Pineocytoma

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Drugs & Therapeutics for Pineocytoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Pineocytoma

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Anatomical Context for Pineocytoma

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32MalaCards
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MalaCards organs/tissues related to Pineocytoma:

32
Pineal, Brain

Animal Models for Pineocytoma or affiliated genes

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Publications for Pineocytoma

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Genetic Variations for Pineocytoma

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Expression for genes affiliated with Pineocytoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pineocytoma

Search GEO for disease gene expression data for Pineocytoma.

Pathways for genes affiliated with Pineocytoma

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Sources:
53Reactome, 37NCBI BioSystems Database, 4Cell Signaling Technology
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Pathways related to Pineocytoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.8ASMT, AANAT
28.0ENO2, GFAP, SYP, RHO, SAG, S100B

Compounds for genes affiliated with Pineocytoma

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Pineocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1estrogen4410.4GFAP
2guanine44 11 2412.2SAG, RHO
3reticulin449.7GFAP, S100B, SYP
4phosphorhodopsin449.5RHO, SAG
52,3-cyclic nucleotide449.5S100B, MBP, GFAP
6b 723449.5CHGA, SYP, S100B
7smcc449.4CHGA, ENO2, SYP
8edss449.2ENO2, MBP, S100B
95-hydroxyindoleacetic acid44 2410.2CHGA, ENO2, ASMT
10l-amino acid449.1SYP, ENO2, S100B, CHGA
11homovanillic acid44 2410.1ENO2, CHGA, GFAP
12dopamine44 28 11 2412.0SAG, CHGA, GFAP, ENO2
13catecholamine448.9ENO2, CHGA, S100B, SYP
14phospholipid448.9MBP, SYP, RHO, SAG, S100B
15hydrogen44 249.8S100B, CHGA, AANAT, SYP, SAG, RHO
16ganglioside448.7ENO2, GFAP, SYP, MBP
17s 100448.7ENO2, S100B, SYP, CHGA, GFAP
18hematoxylin448.7S100B, SYP, CHGA, GFAP, ENO2
19acth448.6S100B, SYP, CHGA, ENO2, GFAP
20amine448.6SYP, ENO2, AANAT, CHGA, RHO
21bromodeoxyuridine448.6ENO2, GFAP, CHGA, S100B
22choline44 11 2410.5S100B, SYP, GFAP, MBP, ENO2
23cyclic amp44 249.5S100B, ASMT, SAG, SYP, CHGA, GFAP
24dbc-amp448.4ASMT, ENO2, AANAT, GFAP, SYP, S100B
25glycogen44 249.3CHGA, GFAP, ENO2, SYP, S100B
26formaldehyde44 249.2S100B, MBP, SYP, CHGA, GFAP, ENO2
27norepinephrine44 11 2410.1AANAT, ENO2, MBP, S100B, CHGA, SYP
28aspartate448.1S100B, ENO2, GFAP, SAG, MBP, RHO
29creatinine448.1ENO2, S100B, MBP, GFAP, CHGA, SYP
30adenylate448.0S100B, SAG, MBP, CHGA, GFAP, ENO2
31threonine448.0GFAP, S100B, SAG, MBP, RHO, AANAT
325-hydroxytryptamine448.0CHGA, ENO2, AANAT, GFAP, SYP, SAG
33leucine448.0ENO2, SAG, SYP, S100B, GFAP, AANAT
34progesterone44 59 28 11 2411.9ENO2, CT49, CHGA, SYP, S100B, GFAP
35dexamethasone44 49 28 1110.9S100B, SYP, ENO2, GFAP, CHGA, AANAT
36glutamine447.9GFAP, S100B, SAG, MBP, ENO2, RHO
37testosterone44 59 11 2410.9CT49, SYP, CHGA, GFAP, ENO2, S100B
38silver447.9CHGA, GFAP, ENO2, SYP, CT49, MBP
39gaba447.8CHGA, S100B, RHO, SYP, ENO2, GFAP
40acetylcholine44 49 28 11 2411.8RHO, GFAP, S100B, CHGA, MBP, SYP
41vegf447.7CHGA, S100B, CT49, RHO, SYP, ENO2
42cysteine447.5AANAT, GFAP, CHGA, SYP, RHO, CT49
43glutamate447.5CHGA, ENO2, GFAP, S100B, RHO, MBP
44lipid447.5RHO, ENO2, GFAP, MBP, CHGA, SYP
45paraffin447.3GFAP, MBP, ENO2, S100B, SAG, CT49
46tyrosine447.2GFAP, SAG, MBP, AANAT, SYP, CHGA
47serine447.2S100B, RHO, CT49, GFAP, SAG, SYP
48retinoic acid44 248.2GFAP, SYP, RHO, CT49, MBP, S100B
49forskolin44 49 119.1GFAP, AANAT, ENO2, SYP, CHGA, CT49
50alanine447.1ENO2, S100B, MBP, CT49, RHO, GFAP

GO Terms for genes affiliated with Pineocytoma

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16Gene Ontology
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Cellular components related to Pineocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1photoreceptor outer segmentGO:0017509.8RHO, SAG
2photoreceptor inner segmentGO:0019178.7ENO2, RHO, SAG

Biological processes related to Pineocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of rhodopsin mediated signaling pathwayGO:0224009.8RHO, SAG
2melatonin biosynthetic processGO:0301879.8ASMT, AANAT
3indolalkylamine biosynthetic processGO:0462199.7ASMT, AANAT
4long-term synaptic potentiationGO:0602919.4GFAP, S100B

Products for genes affiliated with Pineocytoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pineocytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet