MCID: PNC056
MIFTS: 40

Pineocytoma malady

Rare diseases, Neuronal diseases, Cancer diseases, Endocrine diseases categories

Summaries for Pineocytoma

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NIH Rare Diseases:41 A pineocytoma is a tumor of the pineal gland, a small organ in the brain that makes melatonin (a sleep-regulating hormone). pineocytomas most often occur in adults as a solid mass, although they may appear to have fluid-filled (cystic) spaces on images of the brain. signs and symptoms of pineocytomas include headaches, nausea, hydrocephalus, vision abnormalities, and parinaud syndrome. pineocytomas are usually slow-growing and rarely spread to other parts of the body. treatment includes surgery to remove the pineocytoma; most of these tumors do not regrow (recur) after surgery. last updated: 11/13/2014

MalaCards based summary: Pineocytoma, also known as tumor of the pineal region, is related to pineoblastoma and retinoblastoma. An important gene associated with Pineocytoma is ASMT (acetylserotonin O-methyltransferase), and among its related pathways are The phototransduction cascade and tryptophan utilization II. The compounds reticulin and smcc have been mentioned in the context of this disorder. Affiliated tissues include pineal, brain and spinal cord, and related mouse phenotype nervous system.

Wikipedia:63 Pineocytoma, also known as a pinealocytoma, is a benign, slowly growing tumor of the pineal gland.... more...

Aliases & Classifications for Pineocytoma

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Sources:
41NIH Rare Diseases, 43Novoseek, 47Orphanet, 60UMLS, 61UMLS via Orphanet
See all sources

Pineocytoma, Aliases & Descriptions:

Name: Pineocytoma 41 43 47 60
Tumor of the Pineal Region 60
Pineal Gland Neoplasm 60
 
Pinealocytoma 41
Pinealoma 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases, Endocrine diseases


External Ids:

Orphanet47 251912
UMLS via Orphanet61 C0917890

Related Diseases for Pineocytoma

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Diseases related to Pineocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1pineoblastoma30.6GFAP, SAG, ASMT, SYP
2retinoblastoma29.2GFAP, LINC01194, SAG, ASMT, AANAT, SYP
3melanotic neuroectodermal tumor10.5SYP
4dysembryoplastic neuroepithelial tumor10.5SYP
5giant cell glioblastoma10.5GFAP
6somatostatinoma10.5CHGA
7ewing's family of tumors10.5ENO2
8glomus tumor10.5SYP
9epulis10.5ENO2
10alexander disease10.4GFAP
11choroid plexus papilloma10.4GFAP
12secondary progressive multiple sclerosis10.4MBP
13hereditary night blindness10.4SAG, RHO
14acute disseminated encephalomyelitis10.4MBP
15subependymal giant cell astrocytoma10.4SYP, S100B
16islet cell tumor10.4CHGA, SYP
17endocrine gland cancer10.3CHGA, SYP
18retinitis10.3RHO, SAG
19spiradenoma10.3SAG, RHO
20binswanger's disease10.3GFAP, SYP
21night blindness10.3SAG, RHO
22neuroblastoma10.3SYP, ENO2
23myxopapillary ependymoma10.3S100B, GFAP
24anaplastic ependymoma10.3GFAP, S100B
25gemistocytic astrocytoma10.3GFAP, S100B
26amyotrophic lateral sclerosis 110.3SYP, GFAP
27syringoma10.3GFAP, S100B
28sertoli cell tumor10.3SYP, ENO2
29neuroectodermal tumor10.3SYP, ENO2
30myoepithelioma10.3GFAP, S100B
31neuronitis10.3
32glucagonoma10.3CHGA, ENO2
33neurilemmoma10.3ENO2, GFAP
34germinoma10.3
35chordoma10.3GFAP, S100B
36creutzfeldt-jakob disease10.2S100B, ENO2
37pleomorphic adenoma10.2GFAP, S100B
38neonatal hypoxic and ischemic brain injury10.2MBP, ENO2
39retinal degeneration10.2RHO, SAG, GFAP
40central neurocytoma10.2GFAP, CHGA, SYP
41neurofibromatosis10.2S100B, ENO2
42papillary ependymoma10.2S100B, SYP, GFAP
43adrenocortical carcinoma10.2SYP, CHGA
44merkel cell carcinoma10.2ENO2, SYP, CHGA
45pilocytic astrocytoma10.2GFAP, SYP, S100B
46tubular adenocarcinoma10.2CHGA, SYP, ENO2
47gastrinoma10.2ENO2, SYP, CHGA
48large cell carcinoma10.2ENO2, SYP, CHGA
49tuberous sclerosis10.2GFAP, SYP, S100B
50olfactory neuroblastoma10.2SYP, S100B, ENO2

Graphical network of the top 20 diseases related to Pineocytoma:



Diseases related to pineocytoma

Symptoms for Pineocytoma

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Drugs & Therapeutics for Pineocytoma

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Drug clinical trials:

Search ClinicalTrials for Pineocytoma

Search NIH Clinical Center for Pineocytoma

Genetic Tests for Pineocytoma

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Anatomical Context for Pineocytoma

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MalaCards organs/tissues related to Pineocytoma:

31
Pineal, Brain, Spinal cord

Animal Models for Pineocytoma or affiliated genes

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MGI Mouse Phenotypes related to Pineocytoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.6ENO2, MBP, RHO, SYP, AANAT, SAG

Publications for Pineocytoma

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Articles related to Pineocytoma:

(show all 45)
idTitleAuthorsYear
1
Sleep disturbance after pinealectomy in patients with pineocytoma WHOA^I. (22706841)
2012
2
Familial pineocytoma. (22699425)
2012
3
Pineocytoma with diffuse dissemination to the leptomeninges. (22355508)
2011
4
Pineocytoma in a lowland anoa (Bubalus depressicornis). (20961555)
2011
5
Contemporary management of pineocytoma. (21801989)
2011
6
Pleomorphic pineocytoma associated with normal pineal parenchyma: report of a case in a 70-year-old man. (20573029)
2011
7
Factors influencing overall survival rates for patients with pineocytoma. (20461445)
2010
8
Tumor control after surgery and radiotherapy for pineocytoma. (20136388)
2010
9
In-111 pentetreotide in recurrent pineocytoma. (19352270)
2009
10
Pineocytoma mimicking a pineal cyst on imaging: true diagnostic dilemma or a case of incomplete imaging? (17925371)
2008
11
Pineocytoma and pineal parenchymal tumors of intermediate differentiation presenting cytologic pleomorphism: a multicenter study. (18371183)
2008
12
Papillary pineocytoma in child: a case report. (17690754)
2007
13
Pineal parenchymal tumours: I. Pineocytoma: a tumour responsive to platinum-based chemotherapy. (15214646)
2004
14
Pineal epidermoid coinciding with pineocytoma. (14505106)
2003
15
Surgical treatment of a mixed pineocytoma/pineoblastoma in a 72-year-old patient. (12021888)
2002
16
Dorsal midbrain syndrome secondary to a pineocytoma. (11338448)
2001
17
Neuroradiological characteristics of pineocytoma and pineoblastoma. (10952183)
2000
18
Cytogenetic and ultrastructural study of a pineocytoma case report. (11083076)
2000
19
Immunohistochemical, ultrastructural, biochemical and in vitro studies of a pineocytoma. (9600600)
1998
20
Characteristic patterns of Tl-201 chloride and Tc-99m MIBI uptake in a pineocytoma. (9814568)
1998
21
Case report: pineocytoma in a male Fischer 344 rat. (9547871)
1998
22
Pineocytoma with massive intratumoral hemorrhage after ventriculoperitoneal shunt--case report. (9465590)
1997
23
Clinicopathological study on pineocytoma. (7795727)
1995
24
Acquired double elevator palsy in a child with a pineocytoma. (7977612)
1994
25
Pleomorphic pineocytoma with extensive neuronal differentiation: report of two cases. (7847074)
1994
26
Metastatic pineocytoma of the spinal cord after long-term dormancy. (7866570)
1994
27
Pineocytoma with intratumoral hemorrhage following ventriculoperitoneal shunt--case report. (7512231)
1993
28
Chromosomal abnormalities in a pineocytoma. (8281527)
1993
29
Concurrent uveoretinitis and pineocytoma in a child suggests a causal relationship. (1420067)
1992
30
Cystic pineocytoma--case report. (1377802)
1992
31
Immunohistochemical characterization of pineocytomas. (1473313)
1992
32
Cytogenetic study of a pineocytoma. (1486561)
1992
33
Spontaneous malignant pineocytoma in a female Wistar rat. (1832044)
1991
34
MR imaging of pineocytoma: report of two cases. (2105605)
1990
35
Pineocytoma with neuronal differentiation--case report. (1694277)
1990
36
Papillary pineocytoma. Case report. (2352014)
1990
37
Responses of pineocytoma to radiation therapy and chemotherapy--report of two cases. (2480541)
1989
38
Pineocytoma with neuronal differentiation demonstrated immunocytochemically. A case report. (3111171)
1987
39
S-antigen-like immunoreactivity in a human pineocytoma. (3515828)
1986
40
Pineocytoma. Observation of an autopsy case by electron microscopy and cell markers. (6485805)
1984
41
Malignant pineocytoma with prominent papillary features. (7116304)
1982
42
The separation of pineocytoma from pineoblastoma. (6986979)
1980
43
Pineocytoma with astrocytomatous differentiation. (438866)
1979
44
Experimental pineocytoma of the Syrian hamster induced by a human papovavirus (JC). A light and electron microscopic study. (941681)
1976
45
Gangliogliomatous differentiation in a pineocytoma. (4101025)
1970

Variations for Pineocytoma

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Expression for genes affiliated with Pineocytoma

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Search GEO for disease gene expression data for Pineocytoma.

Pathways for genes affiliated with Pineocytoma

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Pathways related to Pineocytoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9RHO, SAG
2
Show member pathways
tryptophan degradation X (mammalian, via tryptamine)36
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA36
tryptophan degradation36
glutaryl-CoA degradation36
serotonin degradation36
NAD de novo biosynthesis36
superpathway of melatonin degradation36
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde36
tryptophan utilization I36
melatonin degradation I36
9.8AANAT, ASMT
3
Show member pathways
catecholamine biosynthesis36
9.8ASMT, AANAT
4
Show member pathways
serotonin and melatonin biosynthesis36
9.8AANAT, ASMT
5
Show member pathways
9.7S100B, GFAP
68.2ENO2, S100B, RHO, SYP, SAG, GFAP

Compounds for genes affiliated with Pineocytoma

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Compounds related to Pineocytoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 112)
idCompoundScoreTop Affiliating Genes
1reticulin439.6GFAP, SYP, S100B
2smcc439.6ENO2, CHGA, SYP
32,3-cyclic nucleotide439.4S100B, MBP, GFAP
4edss439.3MBP, ENO2, S100B
55-hydroxyindoleacetic acid43 2410.2CHGA, ENO2, ASMT
6homovanillic acid43 2410.2CHGA, GFAP, ENO2
7l-amino acid439.2CHGA, SYP, S100B, ENO2
8catecholamine439.0CHGA, SYP, S100B, ENO2
9guanine43 24 1210.9SYP, RHO, CHGA, SAG, ENO2
10phospholipid438.9SAG, MBP, S100B, RHO, SYP
11ganglioside438.9MBP, ENO2, GFAP, SYP
12s 100438.9GFAP, CHGA, SYP, S100B, ENO2
13amine438.8CHGA, AANAT, SYP, RHO, ENO2
14hematoxylin438.8S100B, SYP, CHGA, GFAP, ENO2
15acth438.8CHGA, S100B, SYP, ENO2, GFAP
16hydrogen43 249.8SYP, CHGA, S100B, RHO, AANAT, SAG
17bromodeoxyuridine438.6ENO2, S100B, CHGA, GFAP
18choline43 24 1210.6SYP, S100B, ENO2, MBP, GFAP
19glycogen43 249.6SYP, CHGA, GFAP, S100B, ENO2
20dbc-amp438.5GFAP, ENO2, ASMT, AANAT, SYP, S100B
21cyclic amp43 249.4GFAP, AANAT, SYP, ASMT, SAG, CHGA
22formaldehyde43 249.3CHGA, MBP, GFAP, SYP, S100B, ENO2
23aspartate438.3RHO, ENO2, SAG, MBP, GFAP, S100B
24adenylate438.2MBP, S100B, SAG, CHGA, GFAP, ENO2
25norepinephrine43 24 1210.2AANAT, SYP, ENO2, CHGA, S100B, MBP
26creatinine438.2MBP, SYP, S100B, GFAP, ENO2, CHGA
275-hydroxytryptamine438.2ENO2, GFAP, SAG, ASMT, AANAT, SYP
28threonine438.2S100B, MBP, SAG, AANAT, RHO, GFAP
29dexamethasone43 49 28 1211.1ENO2, GFAP, CHGA, SYP, AANAT, S100B
30leucine438.1SYP, S100B, ENO2, RHO, AANAT, SAG
31glutamine438.1GFAP, RHO, S100B, MBP, ENO2, SYP
32gaba438.0MBP, S100B, GFAP, ENO2, SYP, CHGA
33acetylcholine43 49 28 24 1212.0ENO2, GFAP, MBP, S100B, RHO, SYP
34lactate437.9GFAP, CHGA, S100B, ENO2, MBP
35progesterone43 28 59 24 1211.9LINC01194, SYP, S100B, ENO2, GFAP, CHGA
36silver437.9ENO2, MBP, SYP, CHGA, GFAP, LINC01194
37testosterone43 59 24 1210.9CHGA, SYP, GFAP, LINC01194, ENO2, S100B
38dopamine43 28 24 1210.8GFAP, CHGA, SAG, AANAT, RHO, S100B
39thymidine43 248.7MBP, ENO2, GFAP, LINC01194, S100B
40glutamate437.7RHO, S100B, GFAP, MBP, ENO2, SYP
41lipid437.7GFAP, MBP, S100B, RHO, SYP, SAG
42vegf437.7LINC01194, GFAP, CHGA, RHO, S100B, SYP
43tyrosine437.4SYP, S100B, ENO2, MBP, SAG, CHGA
44estrogen437.4LINC01194, CHGA, SYP, S100B, MBP, GFAP
45cysteine437.3AANAT, MBP, GFAP, S100B, RHO, SYP
46paraffin437.2S100B, CHGA, LINC01194, GFAP, SAG, MBP
47retinoic acid43 248.2S100B, MBP, RHO, ENO2, SYP, CHGA
48alanine437.1SAG, AANAT, RHO, S100B, MBP, LINC01194
49forskolin43 49 129.0CHGA, LINC01194, GFAP, SYP, S100B, AANAT
50serine437.0SAG, GFAP, LINC01194, AANAT, CHGA, SYP

GO Terms for genes affiliated with Pineocytoma

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Cellular components related to Pineocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1photoreceptor inner segmentGO:00019179.6ENO2, RHO

Biological processes related to Pineocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1rhodopsin mediated signaling pathwayGO:00160569.9RHO, SAG
2melatonin biosynthetic processGO:00301879.9AANAT, ASMT
3indolalkylamine biosynthetic processGO:00462199.8AANAT, ASMT
4regulation of neuronal synaptic plasticityGO:00481689.8S100B, SYP
5long-term synaptic potentiationGO:00602919.6GFAP, S100B
6regulation of rhodopsin mediated signaling pathwayGO:00224009.6RHO, SAG

Products for genes affiliated with Pineocytoma

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Sources for Pineocytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet