MCID: PTT006
MIFTS: 62

Pituitary Adenoma malady

Cancer diseases, Endocrine diseases categories
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Summaries for Pituitary Adenoma

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Wikipedia:65 Pituitary adenomas are tumors that occur in the pituitary gland. Pituitary adenomas are generally... more...

MalaCards based summary: Pituitary Adenoma, also known as adenoma of the pituitary gland, is related to chromophobe adenoma and acth-secreting pituitary adenoma. An important gene associated with Pituitary Adenoma is AIP (aryl hydrocarbon receptor interacting protein), and among its related pathways are Hormone ligand-binding receptors and Salivary secretion. The compounds ghrp and buserelin have been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and endothelial, and related mouse phenotypes are tumorigenesis and adipose tissue.

Aliases & Classifications for Pituitary Adenoma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 39NCIt, 34MeSH
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Pituitary Adenoma, Aliases & Descriptions:

Name: Pituitary Adenoma 8 10 44 62
 
Adenoma of the Pituitary Gland 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


External Ids:

Disease Ontology8 DOID:3829
NCIt39 C3329
MeSH34 D010911

Related Diseases for Pituitary Adenoma

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Diseases related to Pituitary Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 266)
idRelated DiseaseScoreTop Affiliating Genes
1chromophobe adenoma31.7PRL, GH1
2acth-secreting pituitary adenoma31.7POMC, PRL, GH1
3acromegaly31.6GH1, SST, PRL, IGF1
4pituitary apoplexy31.4POMC, PRL, GNRH1
5mccune albright syndrome31.4PRL, GH1, GNAS
6cushing's syndrome31.2POMC, SST, GH1
7meningioma31.2SST, SSTR5, SSTR2, GAPDH, MKI67
8craniopharyngioma31.2IGF1, POMC, PRL, GH1
9empty sella syndrome31.1POMC, PRL
10ovarian hyperstimulation syndrome30.9GNRH1, CGA
11acth-independent macronodular adrenal hyperplasia30.8GNAS
12gigantism30.8AIP, IGF1, GNAS, PRL, SST, GH1
13paraganglioma30.8CHGA, SST, SSTR2
14pituitary carcinoma30.7POMC, PRL
15multiple endocrine neoplasia30.7CHGA, GNAS, PRKAR1A
16carney complex30.7PRKAR1A, GNAS, POMC, AIP
17gynecomastia30.4PRL, CGA, GNRH1
18fibrous dysplasia30.4GNAS, GHR, GH1
19ovarian cyst30.4GNRH1, CGA, GNAS
20growth hormone deficiency30.4IGF1, POMC, PRL, GH1, GHR
21leiomyoma30.3MKI67, GNRH1, ADM
22prostate cancer30.2IGF1, GNRH1, MKI67, CHGA, GHR
23anovulation30.2IGF1, GNRH1, PRL, CGA
24hyperprolactinemia30.2GH1, PRL, SST, CGA, GNAS, IGF1
25hypopituitarism30.2CGA, IGF1, GNRH1, GH1, GHR, SST
26neuroendocrine tumor30.1GH1, SSTR2, SST, CHGA, POMC, GNAS
27panhypopituitarism30.0IGF1, GH1, GHR, PRL, POMC
28hypothyroidism29.9GHR, GH1, IGF1, GNRH1, POMC, PRL
29breast cancer29.9SSTR2, CHGA, GNRH1, MKI67, GAPDH
30hypogonadism29.9CGA, IGF1, GH1, PRL, POMC, GNRH1
31melanoma29.8SSTR2, POMC, MKI67, GAPDH, GHR
32hyperthyroidism29.8CGA, IGF1, GH1, GHR, SST, PRL
33adenocarcinoma29.8SSTR2, SSTR1, CHGA, MKI67, SST, GHR
34pheochromocytoma29.7CHGA, SSTR2, SST, GNAS, POMC, SSTR1
35adrenal gland hyperfunction29.6GHR, SST, POMC, PRKAR1A, PRL, GH1
36adenoma29.4POMC, CHGA, PRL, PRKAR1A, SSTR5, SSTR1
37hypoglycemia29.3CHGA, PRL, GNRH1, IGF1, SST, GHR
38insulinoma28.9SSTR5, SSTR1, SST, SSTR2, SSTR3, GHR
39pituitary tumors28.6AIP, IGF1, GNAS, GNRH1, POMC, CHGA
40prolactinoma28.5CGA, GAPDH, GH1, SSTR3, SSTR2, SST
41functioning pituitary adenoma11.0
42non-functioning pituitary adenoma11.0
43growth hormone secreting pituitary adenoma11.0
44familial isolated pituitary adenoma10.8
45somatostatin analog10.7
46thyroiditis10.7
47gangliocytoma10.6
48endotheliitis10.6
49aneurysm10.6
50endogenous depression10.5POMC

Graphical network of the top 20 diseases related to Pituitary Adenoma:



Diseases related to pituitary adenoma

Symptoms for Pituitary Adenoma

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Drugs & Therapeutics for Pituitary Adenoma

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Drug clinical trials:

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Search NIH Clinical Center for Pituitary Adenoma

Genetic Tests for Pituitary Adenoma

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Anatomical Context for Pituitary Adenoma

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MalaCards organs/tissues related to Pituitary Adenoma:

32
Pituitary, Thyroid, Endothelial, Prostate, Testes, Bone, Brain, Breast, B cells, Colon, Kidney, Liver, Lung, Salivary gland, Skin, Ovary, Monocytes, T cells, Hypothalamus, Pons

Animal Models for Pituitary Adenoma or affiliated genes

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Publications for Pituitary Adenoma

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Articles related to Pituitary Adenoma:

(show top 50)    (show all 1383)
idTitleAuthorsYear
1
Unusual case of Cowden-like syndrome, neck paraganglioma, and pituitary adenoma. (23804288)
2014
2
Treatment protocols for growth hormone-secreting pituitary adenomas combined with craniofacial fibrous dysplasia: A case report of atypical McCune-Albright syndrome. (25120617)
2014
3
Analysis of operative efficacy for giant pituitary adenoma. (25163653)
2014
4
Melanoma of the sellar region mimicking pituitary adenoma. (22624497)
2013
5
mTOR is frequently active in GH-secreting pituitary adenomas without influencing their morphopathological features. (23296986)
2013
6
Lycopene and beta-carotene induce growth inhibition and proapoptotic effects on ACTH-secreting pituitary adenoma cells. (23667519)
2013
7
Somatotroph pituitary adenoma with acromegaly and autosomal dominant polycystic kidney disease: SSTR5 polymorphism and PKD1 mutation. (21744088)
2012
8
Radiation-associated sarcoma of the skull base after irradiation for pituitary adenoma. (22532923)
2012
9
Mutation and genomic amplification of the PIK3CA proto-oncogene in pituitary adenomas. (22782554)
2012
10
Glucocorticoid replacement and mortality in patients with nonfunctioning pituitary adenoma. (22872686)
2012
11
A primary proteomic analysis of serum from patients with nonfunctioning pituitary adenoma. (22429349)
2012
12
Spontaneous cerebrospinal fluid rhinorrhea as the initial presentation of growth hormone-secreting pituitary adenoma. (20888068)
2011
13
An ACTH-secreting pituitary adenoma within the sphenoid sinus. (20424367)
2010
14
Down-regulation of Wee1 kinase by a specific subset of microRNA in human sporadic pituitary adenomas. (20668041)
2010
15
Differential gene expression by fiber-optic beadarray and pathway in adrenocorticotrophin-secreting pituitary adenomas. (22166531)
2010
16
Immunohistochemical expression of pituitary tumor transforming gene (PTTG) in pituitary adenomas: a correlative study of tumor subtypes. (20106827)
2010
17
Familial isolated pituitary adenoma: evidence for genetic heterogeneity. (20616498)
2010
18
Use of morning serum cortisol level after transsphenoidal resection of pituitary adenoma to predict the need for long-term glucocorticoid supplementation. (19326985)
2009
19
Younger age is a good predictor of better executive function after surgery for pituitary adenoma in adults. (19638252)
2009
20
Extensive spherical amyloid deposition of pituitary adenoma presenting as pituitary apoplexy. (18280642)
2008
21
Expression of MSX1 in human normal pituitaries and pituitary adenomas. (18379900)
2008
22
Ghrelin stimulates adrenocorticotrophic hormone (ACTH) secretion by human ACTH-secreting pituitary adenomas in vitro. (17280594)
2007
23
Pituitary tumour transforming gene (PTTG) expression correlates with the proliferative activity and recurrence status of pituitary adenomas: a clinical and immunohistochemical study. (16984249)
2006
24
An unusual somatotropin and thyreotropin secreting pituitary adenoma efficiently controlled by Octreotide and Pegvisomant. (16840917)
2006
25
The effect of selective sst1, sst2, sst5 somatostatin receptors agonists, a somatostatin/dopamine (SST/DA) chimera and bromocriptine on the "clinically non-functioning" pituitary adenomas in vitro. (16115652)
2006
26
Chemokine stromal cell-derived factor 1alpha induces proliferation and growth hormone release in GH4C1 rat pituitary adenoma cell line through multiple intracellular signals. (16258074)
2006
27
Effectiveness of treating ovarian hyperstimulation syndrome with cabergoline in two patients with gonadotropin-producing pituitary adenomas. (16952513)
2006
28
Thyroid color flow Doppler sonography: an adjunctive tool for differentiating patients with inappropriate thyrotropin (TSH) secretion due to TSH-secreting pituitary adenoma or resistance to thyroid hormone. (17042684)
2006
29
Immunohistochemical staining of cathepsins B, L and stefin A in human hypophysis and pituitary adenomas. (15816632)
2005
30
Non-functioning pituitary adenomas: clinical features and immunohistochemistry]. (16400431)
2005
31
Prolactin-producing pituitary adenoma with incomplete neuronal transformation: an intermediate adenoma-neuronal tumor. (15173951)
2004
32
Chromogranin A in pituitary adenomas: immunohistochemical detection and plasma concentrations. (15704652)
2004
33
Preoperative lanreotide treatment for GH-secreting pituitary adenomas: effect on tumour volume and predictive factors of significant tumour shrinkage. (12641631)
2003
34
Preliminary study of p16 gene expression in pituitary adenomas]. (12600300)
2003
35
Gamma knife radiosurgery for pituitary adenoma. (12487277)
2002
36
Genesis of pituitary adenomas: state of the art. (11761437)
2001
37
Non-random trisomies of chromosomes 5, 8 and 12 in the prolactinoma sub-type of pituitary adenomas: conventional cytogenetics and interphase FISH study. (10760821)
2000
38
Expression of P27kip1 and Ki-67 in pituitary adenomas: an investigation of marker of adenoma invasiveness. (10189502)
1999
39
Expression of the members of the Ptx family of transcription factors in human pituitary adenomas. (10372733)
1999
40
Expression of an orphan nuclear receptor DAX-1 in human pituitary adenomas. (9666878)
1998
41
A case of non-functioning pituitary adenoma accompanied by a large cyst. (9638270)
1998
42
Plasma chromogranin A in pheochromocytoma, primary hyperparathyroidism and pituitary adenoma in comparison with catecholamine, parathyroid hormone and pituitary hormones. (9228469)
1997
43
Immunohistochemical detection of human natural killer cell like immunoreactivity in human pituitary adenomas, using monoclonal antibody NK-1. (9266438)
1997
44
Pancreastatin secretion by pituitary adenomas and regulation of chromogranin B mRNA expression. (8669489)
1996
45
Interleukin-2 (IL-2) and IL-6 regulate c-fos protooncogene expression in human pituitary adenoma explants. (9027322)
1996
46
Effects of long-term treatment with the gonadotropin-releasing hormone analog nafarelin in patients with non-functioning pituitary adenomas. (8162161)
1994
47
Prolactin-producing pituitary adenoma in a male-to-female transsexual patient with protracted estrogen administration. A morphologic study. (8192565)
1994
48
Pulsatile thyrotropin and prolactin secretion in a patient with a mixed thyrotropin- and prolactin-secreting pituitary adenoma. (8130883)
1994
49
Clinical application of 11C-NMSP to the patients with pituitary adenoma other than prolactinoma]. (8345693)
1993
50
Pituitary adenomas of patients with acromegaly express thyrotropin- releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene. (8396925)
1993

Variations for Pituitary Adenoma

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Expression for genes affiliated with Pituitary Adenoma

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Expression patterns in normal tissues for genes affiliated with Pituitary Adenoma

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Pathways for genes affiliated with Pituitary Adenoma

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Pathways related to Pituitary Adenoma according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9GNRH1, CGA
2
Show member pathways
9.8GNAS, SST, SSTR2
39.8GNAS, PRKAR1A
4
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
9.8GNAS, PRKAR1A
5
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
9.7PRL, GH1, CGA
69.7CGA, PRL, POMC
79.6GH1, GHR, PRL
8
Show member pathways
9.6GH1, GHR, PRL
9
Show member pathways
Type III interferon signaling37
9.6PRL, GHR, GH1
109.6IGF1, GNAS, CGA
119.5IGF1, GHR, GH1
12
Show member pathways
Apoptosis and survival BAD phosphorylation60
Development Alpha 2 adrenergic receptor activation of ERK60
Chemotaxis CXCR4 signaling pathway60
9.4PRKAR1A, GNAS, IGF1
13
Show member pathways
Development Ligand independent activation of ESR1 and ESR260
9.4GNAS, PRKAR1A, IGF1
149.3GH1, IGF1, PRL, GHR
15
Show member pathways
9.3POMC, IGF1, GH1, CGA
16
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
9.3GNAS, GNRH1, CGA, IGF1
17
Show member pathways
9.2PRKAR1A, POMC, CGA, GNAS
18
Show member pathways
9.1GNRH1, IGF1, PRKAR1A, GH1
19
Show member pathways
9.1GNRH1, PRKAR1A, IGF1, GH1
209.1ADM, POMC, CGA, GNAS
21
Show member pathways
9.0GNRH1, GH1, IGF1, PRL, GHR
22
Show member pathways
8.8IGF1, PRL, PRKAR1A, GHR, GH1
23
Show member pathways
Peptide GPCRs37
8.7SSTR5, SSTR1, SSTR2, SSTR3
248.1PRKAR1A, SSTR1, SSTR2, GAPDH, SST
25
Show member pathways
6.0SSTR3, GNAS, GHR, GH1, CGA, SST
26
Show member pathways
5.2POMC, ADM, PRL, PRKAR1A, SSTR5, SSTR1

Compounds for genes affiliated with Pituitary Adenoma

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Compounds related to Pituitary Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 220)
idCompoundScoreTop Affiliating Genes
1ghrp449.4IGF1, SST, PRL, GHR, GH1
2buserelin44 28 1111.4CGA, SST, PRL, GNRH1, IGF1
3naltrexone44 28 50 1112.3POMC, GH1, PRL, GNRH1, IGF1
4clomiphene citrate449.3GH1, CGA, IGF1, GNRH1, PRL
5naloxone44 28 50 1112.2SST, CGA, GH1, GNRH1, POMC, PRL
6hexarelin44 2810.2IGF1, POMC, GH1, GHR, SST, PRL
7leuprolide acetate449.1GH1, GNRH1, IGF1, PRL, CGA, GHR
8111in-pentetreotide449.0SST, CHGA, SSTR5, SSTR1, SSTR2
9som-230289.0SSTR5, SSTR3, SSTR2, SSTR1
10cabergoline44 28 1110.9PRL, GNRH1, SST, GHR, GH1, CGA
11pasireotide44 119.9SST, SSTR1, SSTR2, SSTR3, SSTR5
12bim 23454288.9SSTR1, SSTR2, SSTR3, SSTR5
13cyclosomatostatin618.9SSTR2, SSTR5, SSTR1, SST, SSTR3
14cyn 154806618.9SSTR3, SSTR2, SSTR5, SSTR1, SST
15(1r,1s,3r/1r,1r,3s)-l-054,264618.9SSTR5, SSTR1, SST, SSTR2, SSTR3
16[l-tyr8]cyn 154806288.8SSTR3, SSTR2, SSTR1, SSTR5
17somatostatin61 249.8SSTR2, SST, SSTR5, SSTR1, SSTR3
18[d-tyr8]cyn 154806288.8SSTR3, SSTR2, SSTR1, SSTR5
19dehydroepiandrosterone sulfate448.8POMC, GH1, GHR, PRL, IGF1, GNRH1
20l-362,855288.8SSTR5, SSTR3, SSTR2, SSTR1
21androstenedione44 249.7PRL, GHR, GH1, CGA, IGF1, POMC
22bim 23627288.7SSTR5, SSTR1, SSTR3, SSTR2
23srif-14288.7SSTR3, SSTR2, SSTR1, SSTR5
24[125i]ltt-srif-28288.6SSTR2, SSTR1, SSTR5, SSTR3
25bromocriptine44 28 1110.6CGA, GH1, GHR, SST, PRL, POMC
26thyroxine44 249.5CGA, GH1, GHR, IGF1, GNRH1, PRL
27clonidine44 50 28 1111.5IGF1, POMC, CHGA, PRL, SST, GHR
28[125i]tyr10-cst14288.4SSTR3, SSTR2, SSTR1, SSTR5
29acetylcholine44 50 28 24 1111.8CGA, GH1, GAPDH, SST, CHGA, POMC
30norepinephrine44 24 119.5GH1, GAPDH, CGA, SST, PRL, GNAS
31epinephrine44 24 119.5MKI67, GNRH1, POMC, ADM, CHGA, PRL
32gnrh447.5CHGA, PRL, SST, SSTR2, GHR, GH1
33dexamethasone44 50 28 1110.4PRL, CHGA, IGF1, GNRH1, POMC, ADM
34paraffin447.3ADM, CGA, SSTR2, SSTR1, CHGA, POMC
35creatinine447.3POMC, ADM, CHGA, GHR, GH1, GNRH1
36acth447.3GH1, GHR, SSTR2, SST, GNRH1, GNAS
37lanreotide44 288.3GH1, GHR, SSTR3, SSTR2, SST, SSTR1
38vegf447.3SST, SSTR2, GH1, GAPDH, CHGA, ADM
39cycloheximide447.2CGA, GAPDH, GH1, CHGA, SST, GHR
40progesterone44 28 61 24 1111.1IGF1, MKI67, GNAS, GNRH1, POMC, PRL
41tamoxifen44 50 28 1110.1CGA, IGF1, MKI67, GAPDH, GH1, GHR
42steroid446.9MKI67, POMC, ADM, CHGA, PRL, PRKAR1A
43testosterone44 61 24 119.8CGA, GAPDH, GH1, IGF1, MKI67, GNRH1
44estrogen446.7GAPDH, GH1, GHR, SSTR2, PRL, CHGA
45arginine446.7IGF1, MKI67, GNAS, GNRH1, POMC, ADM
46ribonucleic acid446.3PRL, SSTR5, SSTR1, SSTR2, GHR, GH1
47adenylate446.2GNAS, GNRH1, POMC, ADM, PRKAR1A, SSTR1
48dopamine44 28 24 119.1CHGA, PRL, SSTR5, SSTR1, SST, SSTR2
49glucose445.6CHGA, SST, SSTR2, GHR, GH1, GAPDH
50octreotide44 61 28 118.6GNRH1, GNAS, MKI67, IGF1, CHGA, PRL

GO Terms for genes affiliated with Pituitary Adenoma

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Cellular components related to Pituitary Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.1IGF1, GNRH1, POMC, ADM, SST, GHR
2extracellular regionGO:0055767.0CGA, IGF1, GNAS, GNRH1, POMC, ADM
3cytoplasmGO:0057376.8MKI67, GNAS, POMC, ADM, SSTR1, SSTR2
4plasma membraneGO:0058866.2AIP, IGF1, GNAS, PRKAR1A, SSTR5, SSTR1

Biological processes related to Pituitary Adenoma according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1growth hormone receptor signaling pathwayGO:06039610.1GH1, GHR
2somatostatin signaling pathwayGO:03817010.0SSTR3, SSTR5
3positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.0GH1, IGF1
4hormone-mediated apoptotic signaling pathwayGO:00862810.0SSTR3, SST
5JAK-STAT cascade involved in growth hormone signaling pathwayGO:06039710.0GH1, GHR, PRL
6positive regulation of JAK-STAT cascadeGO:0464279.9PRL, GH1
7positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.9IGF1, GHR, GH1
8regulation of multicellular organism growthGO:0400149.9IGF1, PRL, GHR
9cAMP biosynthetic processGO:0061719.9GNAS, ADM
10cellular response to glucocorticoid stimulusGO:0713859.8SSTR2, SSTR3
11insulin-like growth factor receptor signaling pathwayGO:0480099.8IGF1, GHR
12positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.8GH1, GHR, IGF1
13regulation of insulin secretionGO:0507969.7SSTR5, PRKAR1A, GNAS
14developmental growthGO:0485899.7CGA, ADM, GNAS
15peptide hormone processingGO:0164869.6CGA, POMC
16female pregnancyGO:0075659.5GNAS, GNRH1, ADM, PRL
17digestionGO:0075869.5SSTR1, SST, SSTR2
18response to nutrientGO:0075849.4SSTR1, SST, SSTR2
19cellular response to estradiol stimulusGO:0713929.3SSTR1, SSTR2, SSTR3
20cell surface receptor signaling pathwayGO:0071669.2SST, SSTR1, PRL
21cerebellum developmentGO:0215499.2SSTR1, SSTR2, SSTR3
22forebrain developmentGO:0309009.2SSTR1, SSTR2, SSTR3
23G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.1SSTR5, SSTR1, SSTR2, SSTR3
24response to starvationGO:0425948.7ADM, SSTR1, SSTR2, SSTR3
25signal transductionGO:0071658.4AIP, IGF1, GNRH1, POMC, ADM, PRKAR1A
26negative regulation of cell proliferationGO:0082857.7IGF1, GNRH1, ADM, SSTR5, SSTR1, SST
27cell-cell signalingGO:0072677.6CGA, GNRH1, POMC, ADM, SSTR1, SST

Molecular functions related to Pituitary Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1prolactin receptor bindingGO:00514810.0GH1, PRL
2somatostatin receptor activityGO:0049948.6SSTR5, SSTR1, SSTR2, SSTR3
3hormone activityGO:0051798.0CGA, IGF1, GNRH1, POMC, ADM, PRL
4protein bindingGO:0055155.6AIP, IGF1, MKI67, GNAS, ADM, PRL

Products for genes affiliated with Pituitary Adenoma

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3CDC
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25ICD10
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27ICD9CM
28IUPHAR
29KEGG
34MeSH
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36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
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52QIAGEN
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