MCID: PTT006
MIFTS: 64

Pituitary Adenoma malady

Endocrine diseases category

Summaries for Pituitary Adenoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Pituitary adenomas are noncancerous tumors that occur in the pituitary gland. Pituitary adenomas are... more...

MalaCards: Pituitary Adenoma, also known as pituitary adenoma, no icd-o subtype, is related to adenoma and growth hormone secreting pituitary adenoma. An important gene associated with Pituitary Adenoma is AVPR1B (arginine vasopressin receptor 1B), and among its related pathways are Signaling by GPCR and Class A/1 (Rhodopsin-like receptors). The compounds octreotide and ribonucleic acid have been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and endothelial, and related mouse phenotypes are homeostasis/metabolism and nervous system.

Aliases & Classifications for Pituitary Adenoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

pituitary adenoma 8 10 44 60
pituitary adenoma, no icd-o subtype 8
adenoma of the pituitary gland 8
pituitary adenoma - disorder 8


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Disease Ontology8 DOID:3829
MeSH34 D010911
NCIt39 C3329

Related Diseases for Pituitary Adenoma

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17GeneCards, 18GeneDecks
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Diseases related to Pituitary Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 284)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma32.3CGA, GHR, MKI67, AVPR1B, GAPDH, GNRH1
2growth hormone secreting pituitary adenoma31.4AIP, RA9
3acromegaly31.1PRL, IGF1, SST, GH1
4acth-secreting pituitary adenoma31.1RA9, AIP
5pituitary apoplexy31.0GNRH1, POMC, PRL
6prolactinoma30.9AIP, RA9
7chromophobe adenoma30.9PRL, GH1
8thyroiditis30.9POMC, CGA
9meningioma30.9SST, MKI67, SSTR2, SSTR5, GAPDH
10craniopharyngioma30.8IGF1, GH1, POMC, PRL
11hypopituitarism30.7GNRH1, CGA, GHR, GH1, PRL, SST
12mccune albright syndrome30.7PRL, GH1, GNAS
13cushing's syndrome30.7POMC, SST, GH1
14hyperprolactinemia30.6GNRH1, GNAS, POMC, IGF1, SST, PRL
15adenocarcinoma30.5SST, SSTR2, CHGA, GAPDH, GHR, MKI67
16carney complex30.5POMC, AIP, GNAS
17pituitary cancer30.5PRL, POMC
18hypothyroidism30.5CGA, GNAS, GNRH1, IGF1, GHR, GH1
19prostate cancer30.5CHGA, GHR, GNRH1, MKI67, IGF1
20empty sella syndrome30.5PRL, POMC
21hyperthyroidism30.4IGF1, SST, PRL, GH1, GHR, CGA
22papillary carcinoma30.4SSTR2, GAPDH, CHGA, GNAS, MKI67
23paraganglioma30.4SST, CHGA, SSTR2
24sarcoma30.4SSTR2, MKI67, GAPDH
25pituitary tumors30.3GHR, GH1, CHGA, SSTR5, SSTR2, SSTR1
26neuroendocrine tumor30.3GNAS, GH1, SST, POMC, MKI67, SSTR2
27pheochromocytoma30.3CHGA, SST, SSTR5, SSTR2, SSTR1, GNAS
28parathyroid adenoma30.3GNAS, CHGA
29pituitary gland disease30.2CGA, GH1, PRL, IGF1
30graves' disease30.2CGA, GNAS
31leukemia30.2GHR, GAPDH
32adrenal adenoma30.2MKI67, CHGA, POMC
33insulinoma30.0GHR, SSTR5, CHGA, GH1, SSTR1, SSTR2
34hypoglycemia30.0SST, CHGA, IGF1, PRL, GH1, POMC
35hypogonadism30.0CGA, GH1, GNRH1, POMC, PRL, IGF1
36adrenal gland hyperfunction30.0SST, PRL, POMC, GH1, GHR
37panhypopituitarism30.0POMC, IGF1, GHR, PRL, GH1
38melanoma30.0SSTR2, MKI67, POMC, GHR, GAPDH
39anovulation30.0IGF1, GNRH1, CGA, PRL
40gynecomastia30.0GNRH1, CGA, PRL
41ovarian cyst30.0GNAS, GNRH1, CGA
42hyperparathyroidism29.9CHGA
43breast cancer29.9GNRH1, MKI67, SSTR2, CHGA, GAPDH
44leiomyoma29.9GNRH1, MKI67
45functioning pituitary adenoma11.0
46gangliocytoma10.5
47familial isolated pituitary adenoma10.5
48neuronitis10.5
49fetal adenoma10.4
50pregnancy adenoma10.4

Graphical network of the top 20 diseases related to Pituitary Adenoma:



Diseases related to pituitary adenoma

Clinical Features for Pituitary Adenoma

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Drugs & Therapeutics for Pituitary Adenoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Pituitary Adenoma

Genetic Tests for Pituitary Adenoma

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Anatomical Context for Pituitary Adenoma

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32MalaCards
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MalaCards organs/tissues related to Pituitary Adenoma:

32
Pituitary, Thyroid, Endothelial, Testes, Prostate, Bone, Ovary, Brain, B cells, Lung, Colon, Skin, Breast, Kidney, Liver, T cells, Salivary gland, Hypothalamus, Pons, Monocytes

Animal Models for Pituitary Adenoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pituitary Adenoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.3AVPR1B, GNAS, GNRH1, GAPDH, CGA, GHR
2MP:000363111.8GNAS, GNRH1, CGA, GHR, GH1, PRL
3MP:000537811.7GHR, CGA, GAPDH, GNRH1, GNAS, GH1
4MP:000538511.3GAPDH, GHR, CHGA, SSTR2, IGF1, AIP
5MP:000537011.2GNAS, GNRH1, GAPDH, GHR, GH1, PRL
6MP:000537911.0GHR, SSTR5, AIP, AVPR1B
7MP:000536710.9GNAS, GNRH1, GAPDH, GHR, CHGA, IGF1

Publications for Pituitary Adenoma

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50PubMed
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Articles related to Pituitary Adenoma:

(show top 50)    (show all 1538)
idTitleAuthorsYear
1
Molecular status of pituitary carcinoma and atypical adenoma that contributes the effectiveness of temozolomide. (23955641)
2013
2
Characterization of SNARE Proteins in Human Pituitary Adenomas: Targeted Secretion Inhibitors as a New Strategy for the Treatment of Acromegaly? (24152687)
2013
3
Ectopic pituitary adenoma associated with an empty sella: a case report and review of the literature. (21699614)
2013
4
A primary proteomic analysis of serum from patients with nonfunctioning pituitary adenoma. (22429349)
2012
5
Growth hormone secreting pituitary adenoma associated with Rathke's cleft cyst. (22824691)
2012
6
Immunohistochemical detection of FSH receptors in pituitary adenomas and adrenal tumors. (23042261)
2012
7
Differential expression of folate receptor alpha in pituitary adenomas and its relationship to tumor behavior. (22089756)
2012
8
Transsphenoidal surgery for pituitary adenoma: indications and outcomes. (23275332)
2012
9
Coexistence of intracranial aneurysm in 800 patients with surgically confirmed pituitary adenoma. (22304451)
2012
10
Spontaneous cerebrospinal fluid rhinorrhea as the initial presentation of growth hormone-secreting pituitary adenoma. (20888068)
2011
11
Ghrelin immunoexpression in pituitary adenomas. (21340501)
2011
12
Co-expression of somatostatin receptor subtypes and estrogen receptor-I+ mRNAs by non-functioning pituitary adenomas in young patients. (20797424)
2011
13
Thyrotropin secreting pituitary adenoma accompanying a silent somatotropinoma. (21845579)
2011
14
Hyperthyroidism caused by a pituitary adenoma. (21464161)
2011
15
Extralabel use of cabergoline in the treatment of a pituitary adenoma in a rat. (21879967)
2011
16
Thyrotropin-secreting pituitary adenoma in an adolescent boy: challenges in management. (20624809)
2010
17
An aged bull with concurrent thyroid C cell carcinoma, adrenal pheochromocytoma and pituitary chromophobe adenoma. (19262038)
2009
18
Radiation-induced optic neuritis after pituitary adenoma radiosurgery in a patient with multiple sclerosis: case report. (19099198)
2009
19
Surgical results of growth hormone-secreting pituitary adenoma. (19516943)
2009
20
Long-term results of stereotactic radiosurgery in secretory pituitary adenomas. (19509108)
2009
21
Pathology, pathogenesis and therapy of growth hormone (GH)-producing pituitary adenomas: technical advances in histochemistry and their contribution. (19759870)
2009
22
Cranial autonomic symptoms in patients with pituitary adenoma presenting with headaches. (19673362)
2009
23
Development of thyroid storm after surgical resection of a thyrotropin-secreting pituitary adenoma. (18996794)
2008
24
Delayed chiasmal herniation after transsphenoidal removal of a pituitary adenoma - case report. (18365965)
2008
25
Expression of survivin in invasive pituitary adenoma. (18998006)
2008
26
Control of pituitary adenoma cell proliferation by somatostatin analogs, dopamine agonists and novel chimeric compounds. (17413185)
2007
27
Discovery of a pituitary adenoma following treatment with a gonadotropin-releasing hormone agonist in a patient with prostate cancer. (16448441)
2006
28
Ectopic pituitary adenoma located at the pituitary stalk. Case report. (15990716)
2005
29
Preliminary study of p16 gene expression in pituitary adenomas]. (12600300)
2003
30
Expression of mPOU protein in the human pituitary adenomas. (15141147)
2003
31
Metamorphosis of a non-functioning pituitary adenoma to Cushing's disease. (12138984)
2001
32
Detection of gonadotropin-releasing hormone receptor in normal human pituitary cells and pituitary adenomas using immunohistochemistry. (11037346)
2000
33
New medical approaches in pituitary adenomas. (10971110)
2000
34
Pit-1 positive alpha-subunit positive nonfunctioning human pituitary adenomas: a dedifferentiated GH cell lineage? (11081207)
1999
35
Activity of growth hormone-releasing peptide-2 in cultured cells of human pituitary adenoma and its interaction with growth hormone-releasing hormone and somatostatin]. (9559140)
1998
36
Preoperative treatment of growth hormone-producing pituitary adenoma with continuous subcutaneous infusion of octreotide. (9700482)
1998
37
Cushing's disease due to a giant pituitary adenoma in early infancy: CT and MRI features. (8598995)
1996
38
Expression of the transferrin receptor in human anterior pituitary adenomas is confined to gonadotrophinomas. (8706315)
1996
39
Increased serum thyrotropin in a subacute thyroiditis patients after incomplete removal of thyrotropin-producing pituitary adenoma. (8915707)
1996
40
Expression of three somatostatin receptor subtypes in pituitary adenomas: evidence for preferential SSTR5 expression in the mammosomatotroph lineage. (7521350)
1994
41
Ubiquitin immunoreactivity in corticotrophs following glucocorticoid treatment and in pituitary adenomas. (8382913)
1993
42
Hormonal and radiological effects of megavoltage radiotherapy in patients with growth hormone-secreting pituitary adenoma. (8258643)
1993
43
Effect of the GABAA agonist muscimol on prolactin secretion from human prolactin-secreting adenomas and GH3 rat pituitary tumour cells. (1335954)
1992
44
Immunohistochemical studies of chromogranins (A and C) in pituitary adenomas. (1717962)
1991
45
Pituitary Cushing's disease arising from a previously non-functional corticotrophic chromophobe adenoma. (2985300)
1985
46
Multiple endocrine neoplasia. Pituitary adenoma, multicentric papillary thyroid carcinoma, bilateral carotid body paraganglioma, parathyroid hyperplasia, gastric leiomyoma, and systemic amyloidosis. (7137085)
1982
47
Letter: Pituitary adenoma in McCune-Albright syndrome: follow-up information. (932890)
1976
48
The fine structure of the human pituitary chromophobe adenoma with special reference to the classification of this tumor. (5690234)
1968
49
RELATIONSHIP BETWEEN VISUAL FIELD DEFECTS AND ENCEPHALOGRAPHIC CHANGES IN 48 CASES OF PITUITARY CHROMOPHOBE ADENOMA. (14213934)
1964
50
BASOPHIL ADENOMA OF THE PITUITARY GLAND WITH RENAL CHANGES. (20778876)
1935

Genetic Variations for Pituitary Adenoma

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Expression for genes affiliated with Pituitary Adenoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pituitary Adenoma

Search GEO for disease gene expression data for Pituitary Adenoma.

Pathways for genes affiliated with Pituitary Adenoma

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 12EMD Millipore
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Compounds for genes affiliated with Pituitary Adenoma

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Pituitary Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 174)
idCompoundScoreTop Affiliating Genes
1octreotide44 59 28 1115.5SSTR3, SST, SSTR1, SSTR2, SSTR5, CHGA
2ribonucleic acid4412.3CGA, SSTR5, GH1, POMC, GHR, IGF1
3gnrh4412.2MKI67, POMC, IGF1, SST, SSTR2, CHGA
4acth4412.2SST, IGF1, POMC, GNAS, GNRH1, GHR
5arginine4412.1SST, IGF1, POMC, MKI67, AVPR1B, CHGA
6progesterone44 59 28 11 2416.0GH1, CGA, POMC, IGF1, SSTR2, GNAS
7testosterone44 59 11 2415.0CHGA, SST, CGA, GHR, GH1, IGF1
8lanreotide44 2813.0GHR, GH1, PRL, CHGA, SSTR5, SSTR2
9tamoxifen44 49 28 1115.0GH1, IGF1, SSTR2, CHGA, PRL, MKI67
10adenylate4411.9SSTR1, SST, SSTR2, POMC, CHGA, GH1
11dopamine44 28 11 2414.9IGF1, SSTR5, SSTR2, SSTR1, CHGA, GHR
12epinephrine44 11 2413.8MKI67, CHGA, POMC, SST, CGA, GAPDH
13norepinephrine44 11 2413.8PRL, CHGA, SST, GH1, GAPDH, GNAS
14clonidine44 28 1113.8POMC, IGF1, SST, CHGA, PRL, GH1
15thyroxine44 2412.7SST, POMC, IGF1, PRL, GH1, GHR
16cabergoline28 44 1113.7GHR, CGA, GNRH1, GH1, PRL, SST
17dehydroepiandrosterone sulfate4411.6PRL, GH1, GHR, CGA, GNRH1, POMC
18androstenedione44 2412.6GHR, CGA, POMC, PRL, GH1, GNRH1
19bromocriptine28 44 1113.6GNRH1, CGA, GHR, SST, POMC, PRL
20hexarelin44 2812.5PRL, SST, GH1, POMC, GHR, IGF1
21leuprolide acetate4411.5GNRH1, CGA, GHR, GH1, PRL, IGF1
22naloxone44 49 28 1114.5GH1, CGA, POMC, GNRH1, PRL, SST
23steroid4411.4GNAS, GNRH1, CGA, GHR, GH1, MKI67
24pasireotide44 1112.4SSTR2, SSTR1, SST, SSTR3, SSTR5
25(1r,1s,3r/1r,1r,3s)-l-054,2645911.4SSTR3, SST, SSTR1, SSTR2, SSTR5
26cyn 1548065911.4SSTR3, SST, SSTR2, SSTR5, SSTR1
27cyclosomatostatin5911.4SSTR3, SST, SSTR1, SSTR2, SSTR5
28somatostatin59 2412.4SSTR2, SST, SSTR3, SSTR5, SSTR1
29ghrp4411.4IGF1, PRL, GH1, GHR, SST
30buserelin44 28 1113.3GNRH1, IGF1, SST, PRL, CGA
31glucose4411.3GAPDH, SSTR2, POMC, IGF1
32som-2302811.2SSTR1, SSTR3, SSTR2, SSTR5
33ke 1082811.2SSTR3, SSTR5, SSTR2, SSTR1
34[125i]cgp 239962811.2SSTR3, SSTR1, SSTR2, SSTR5
35bim 230522811.2SSTR3, SSTR1, SSTR2, SSTR5
36111in-pentetreotide4411.2CHGA, SST, SSTR5
37cgp 239962811.2SSTR3, SSTR2, SSTR5, SSTR1
38l-362,8552811.2SSTR3, SSTR1, SSTR2, SSTR5
39[l-tyr8]cyn 1548062811.2SSTR3, SSTR1, SSTR2, SSTR5
40[d-tyr8]cyn 1548062811.2SSTR3, SSTR1, SSTR2, SSTR5
41bim 234542811.1SSTR2, SSTR1, SSTR3, SSTR5
42bim 236272811.1SSTR5, SSTR3, SSTR1, SSTR2
43cst-172811.1SSTR5, SSTR2, SSTR1, SSTR3
44[125i]tyr10-cst142811.1SSTR1, SSTR3, SSTR2, SSTR5
45[125i]ltt-srif-282811.0SSTR5, SSTR2, SSTR1, SSTR3
46quinagolide4411.0SST, IGF1, PRL, GH1
47naltrexone44 49 28 1114.0GNRH1, POMC, IGF1, PRL, GH1
48srif-282811.0SSTR5, SSTR2, SSTR1, SSTR3
49srif-142810.9SSTR5, SSTR2, SSTR1, SSTR3
50clomiphene citrate4410.7IGF1, GNRH1, CGA, GH1, PRL

GO Terms for genes affiliated with Pituitary Adenoma

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16Gene Ontology
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Cellular components related to Pituitary Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.5POMC, GNAS, GNRH1, CGA, GHR, GH1
2plasma membraneGO:00588611.5GAPDH, GHR, SSTR5, SSTR2, SSTR1, SSTR3
3extracellular spaceGO:00561510.8GNRH1, GHR, GH1, SST, IGF1, POMC
4secretory granuleGO:03014110.7PRL, CHGA, POMC

Biological processes related to Pituitary Adenoma according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1cell-cell signalingGO:00726711.6POMC, GNRH1, CGA, SSTR2, SSTR1, SST
2negative regulation of cell proliferationGO:00828511.6GNRH1, SSTR5, SSTR2, SSTR1, SST, SSTR3
3G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718711.2SSTR5, SSTR2, SSTR1, SSTR3
4response to nutrientGO:00758411.2PRL, SSTR2, SSTR1, SST
5cellular response to estradiol stimulusGO:07139211.1SSTR3, SSTR1, SSTR2
6positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252311.1GHR, GH1, IGF1
7JAK-STAT cascade involved in growth hormone signaling pathwayGO:06039711.1PRL, GH1, GHR
8regulation of multicellular organism growthGO:04001411.1GHR, PRL, IGF1
9cerebellum developmentGO:02154911.1SSTR2, SSTR1, SSTR3
10response to starvationGO:04259411.1SSTR3, SSTR1, SSTR2
11digestionGO:00758611.0SST, SSTR1, SSTR2
12forebrain developmentGO:03090011.0SSTR3, SSTR1, SSTR2
13response to estradiol stimulusGO:03235511.0GHR, GH1, PRL
14positive regulation of peptidyl-tyrosine phosphorylationGO:05073111.0IGF1, GH1, GHR
15somatostatin signaling pathwayGO:03817011.0SSTR3, SSTR5
16hormone-mediated apoptotic signaling pathwayGO:00862810.9SST, SSTR3
17female pregnancyGO:00756510.9GNAS, GNRH1, PRL
18ovulation cycleGO:04269810.8PRL, GNRH1
19growth hormone receptor signaling pathwayGO:06039610.8GH1, GHR
20positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.7IGF1, GH1
21insulin-like growth factor receptor signaling pathwayGO:04800910.7IGF1, GHR
22positive regulation of JAK-STAT cascadeGO:04642710.6PRL, GH1
23cellular response to glucocorticoid stimulusGO:07138510.4SSTR3, SSTR2

Molecular functions related to Pituitary Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517911.1POMC, GNRH1, CGA, GH1, PRL, SST
2prolactin receptor bindingGO:00514810.7PRL, GH1
3somatostatin receptor activityGO:00499410.6SSTR3, SSTR1, SSTR2, SSTR5

Products for genes affiliated with Pituitary Adenoma

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  • Antibodies
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Sources for Pituitary Adenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet