MCID: PTT006
MIFTS: 56

Pituitary Adenoma malady

Summaries for Pituitary Adenoma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Pituitary adenomas are noncancerous tumors that occur in the pituitary gland. Pituitary adenomas are... more...

MalaCards: Pituitary Adenoma, also known as pituitary adenoma, no icd-o subtype, is related to adenoma and growth hormone secreting pituitary adenoma. An important gene associated with Pituitary Adenoma is AVPR1B (arginine vasopressin receptor 1B), and among its related pathways are Signaling by GPCR and Class A/1 (Rhodopsin-like receptors). The compounds octreotide and ribonucleic acid have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and nervous system.

Aliases & Classifications for Pituitary Adenoma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 40NCIt, 57SNOMED-CT
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Aliases & Descriptions:

pituitary adenoma 8 10 45 61
pituitary adenoma, no icd-o subtype 8
adenoma of the pituitary gland 8
pituitary adenoma - disorder 8


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Disease Ontology8 DOID:3829
MeSH35 D010911
NCIt40 C3329

Related Diseases for Pituitary Adenoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pituitary Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 269)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma32.4CGA, GHR, MKI67, AVPR1B, GAPDH, GNRH1
2growth hormone secreting pituitary adenoma31.5AIP, RA9
3acromegaly31.2GNAS, GHR, GH1, PRL, SSTR5, SSTR2
4acth-secreting pituitary adenoma31.1RA9, AIP
5pituitary apoplexy31.1GNRH1, POMC, PRL
6pituitary tumors31.0GHR, GH1, CHGA, SSTR5, SSTR2, SSTR1
7prolactinoma31.0AIP, RA9
8chromophobe adenoma31.0PRL, GH1
9cushing's syndrome30.8POMC, SST, GH1
10multiple endocrine neoplasia30.7CHGA, GNAS
11mccune albright syndrome30.7PRL, GH1, GNAS
12gigantism30.7GH1, PRL, SST, IGF1, AIP, GNAS
13hyperprolactinemia30.6GNRH1, GNAS, POMC, IGF1, SST, PRL
14adenocarcinoma30.6SST, SSTR2, CHGA, GAPDH, GHR, MKI67
15carney complex30.6POMC, AIP, GNAS
16empty sella syndrome30.5PRL, POMC
17papillary carcinoma30.4SSTR2, GAPDH, CHGA, GNAS, MKI67
18paraganglioma30.4SST, CHGA, SSTR2
19pheochromocytoma30.4CHGA, SST, SSTR5, SSTR2, SSTR1, GNAS
20growth hormone deficiency30.4IGF1, PRL, GH1, POMC, GHR
21nelson syndrome30.2POMC, SST, PRL
22graves' disease30.2CGA, GNAS
23adrenal adenoma30.2MKI67, CHGA, POMC
24insulinoma30.0GHR, SSTR5, CHGA, GH1, SSTR1, SSTR2
25hypoglycemia30.0SST, CHGA, IGF1, PRL, GH1, POMC
26adrenal gland hyperfunction30.0SST, PRL, POMC, GH1, GHR
27panhypopituitarism30.0POMC, IGF1, GHR, PRL, GH1
28anovulation30.0IGF1, GNRH1, CGA, PRL
29gynecomastia30.0GNRH1, CGA, PRL
30thyroiditis30.0POMC, CGA
31teratoma30.0CGA
32somatostatin analog10.8
33familial isolated pituitary adenoma10.7
34thyroid adenoma10.6
35silent pituitary adenoma10.6
36gangliocytoma10.6
37n syndrome10.5
38mccune–albright syndrome10.5
39hypoxia10.5
40headache10.5
41choristoma10.4
42fetal adenoma10.4
43pregnancy adenoma10.4
44papillary adenoma10.4
45pituitary tumor, invasive10.4
46intracranial aneurysm10.4
47lymphocytic hypophysitis10.4
48mixed cell adenoma10.3
49ovarian hyperstimulation syndrome10.3
50aip-related familial isolated pituitary adenomas10.3

Graphical network of the top 20 diseases related to Pituitary Adenoma:



Diseases related to pituitary adenoma

Clinical Features for Pituitary Adenoma

Drugs & Therapeutics for Pituitary Adenoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Pituitary Adenoma

Drug clinical trials:

Search ClinicalTrials for Pituitary Adenoma

Search NIH Clinical Center for Pituitary Adenoma

Search CenterWatch for Pituitary Adenoma

Genetic Tests for Pituitary Adenoma

Anatomical Context for Pituitary Adenoma

Animal Models for Pituitary Adenoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Pituitary Adenoma

Sources:
51PubMed
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Articles related to Pituitary Adenoma:

(show top 50)    (show all 1548)
idTitleAuthorsYear
1
Incidental Superior Hypophygeal Artery Aneurysm Embedded within Pituitary Adenoma. (24278658)
2013
2
Peptide receptor radionuclide therapy in a patient with disabling non-functioning pituitary adenoma. (23740146)
2013
3
Cushing's disease due to mixed pituitary adenoma-gangliocytoma of the posterior pituitary gland presenting with Aspergillus sp. sinus infection. (23611590)
2013
4
Inhibition of PI3K/AKT/mTOR pathway enhances temozolomide-induced cytotoxicity in pituitary adenoma cell lines in vitro and xenografted pituitary adenoma in female nude mice. (23384836)
2013
5
Undifferentiated sarcoma of the cavernous sinus after gamma knife radiosurgery for pituitary adenoma. (23587603)
2013
6
Follicle-stimulating hormone-secreting pituitary adenoma manifesting as recurrent ovarian cysts in a young woman--latent risk of unidentified ovarian hyperstimulation: a case report. (24119690)
2013
7
Somatotroph pituitary adenoma with acromegaly and autosomal dominant polycystic kidney disease: SSTR5 polymorphism and PKD1 mutation. (21744088)
2012
8
Nelfinavir induces radiation sensitization in pituitary adenoma cells. (21811091)
2011
9
Visual vignette. Ectopic ACTH-secreting pituitary adenoma. (21803709)
2011
10
Evidence of improved surgical outcome following endoscopy for nonfunctioning pituitary adenoma removal. (21456922)
2011
11
Pituitary apoplexy in non-functioning pituitary adenomas: long term follow up is important because of significant numbers of tumour recurrences. (21521336)
2011
12
Metabolic, cardiovascular, and cerebrovascular outcomes in growth hormone-deficient subjects with previous cushing's disease or non-functioning pituitary adenoma. (20022992)
2010
13
The CXCR4 antagonist AMD3100 suppresses hypoxia-mediated growth hormone production in GH3 rat pituitary adenoma cells. (20309720)
2010
14
Possible relevance between prohormone convertase 2 expression and tumor growth in human adrenocorticotropin-producing pituitary adenoma. (20501680)
2010
15
Analysis of differential gene expression by bead-based fiber-optic array in growth-hormone-secreting pituitary adenomas. (22993617)
2010
16
A rare case of follicular thyroid carcinoma in a patient with thyrotropin-secreting pituitary adenoma. (19390430)
2009
17
Expression of survivin in invasive pituitary adenoma. (18998006)
2008
18
Effects of selective somatostatin analogs and cortistatin on cell viability in cultured human non-functioning pituitary adenomas. (18276067)
2008
19
PTTG is a secretory protein in human pituitary adenomas and in mouse pituitary tumor cell lines. (17652795)
2007
20
Nonfunctioning pituitary adenoma: incidence, causes of death and quality of life in relation to pituitary function. (17356906)
2007
21
Silent growth hormone secreting pituitary adenomas: IGF-1 is not sufficient to exclude growth hormone excess. (17270100)
2007
22
Does the prevalence of gsp mutations in GH-secreting pituitary adenomas differ geographically or racially? Prevalence of gsp mutations in Japanese patients revisited. (16402935)
2006
23
Pituitary adenoma: a DNA flow cytometric study of 192 clinicopathologically characterized tumors. (15803804)
2005
24
"Honeycomb Golgi" in pituitary adenomas: not a marker of gonadotroph adenomas. (14739492)
2003
25
Sarcomatous change after sellar irradiation in a growth hormone-secreting pituitary adenoma. (14672272)
2003
26
Pituitary adenoma in Carney complex: an immunohistochemical, ultrastructural, and immunoelectron microscopic study. (12537759)
2002
27
Pituitary adenomas in man and mouse: oncogenic potential of a truncated fibroblast growth factor receptor 4. (11781345)
2002
28
In vitro effect of human recombinant leptin and expression of leptin receptors on growth hormone-secreting human pituitary adenomas. (12354126)
2002
29
Expression of cyclic adenosine 3',5'-monophosphate (cAMP)-responsive element binding protein and inducible-cAMP early repressor genes in growth hormone-secreting pituitary adenomas with or without mutations of the Gsalpha gene. (11344215)
2001
30
Coexistence of thyrotropin-producing pituitary adenoma with papillary adenocarcinoma of the thyroid--a case report and surgical strategy. (12501979)
2001
31
Absence of somatostatin receptor type 2 A mutations and gip oncogene in pituitary somatotroph adenomas. (10651751)
2000
32
Growth promoting effect of human plasma ultrafiltrate bioactive fraction (TBP) for human non-functioning pituitary adenoma cells in vitro. (11194707)
2000
33
New medical approaches in pituitary adenomas. (10971110)
2000
34
Long-term treatment with the dopamine agonist quinagolide of patients with clinically non-functioning pituitary adenoma. (11078985)
2000
35
Proliferation markers in different types of clinically non-secreting pituitary adenomas. (11081200)
1999
36
Expression of calcium-sensing receptor and characterization of intracellular signaling in human pituitary adenomas. (10443690)
1999
37
A case of non-functioning pituitary adenoma accompanied by a large cyst. (9638270)
1998
38
Pituitary adenylate-cyclase-activating polypeptide (PACAP) binding sites and PACAP/vasoactive intestinal polypeptide receptor expression in human pituitary adenomas. (9846969)
1998
39
Pituitary adenoma and bilateral male breast cancer: an unusual association. (9040805)
1997
40
Immunohistochemical expression of retinoid X receptor isoforms in human pituitaries and pituitary adenomas. (9143002)
1997
41
TSH-Secreting Pituitary Adenoma: Current Management and Review. (17170995)
1997
42
Differentiating neuroblastoma of pituitary gland: neuroblastic transformation of epithelial adenoma cells. Case report. (8893739)
1996
43
Pediatric pituitary adenomas. (7731505)
1995
44
Pulsatile thyrotropin and prolactin secretion in a patient with a mixed thyrotropin- and prolactin-secreting pituitary adenoma. (8130883)
1994
45
Recovery of visual and endocrine function following transsphenoidal surgery of large nonfunctioning pituitary adenomas. (7868814)
1994
46
Congenital gigantism due to growth hormone-releasing hormone excess and pituitary hyperplasia with adenomatous transformation. (8421089)
1993
47
GH-secreting pituitary adenomas--correlation between clinical features, growth potential and histopathological studies]. (7507690)
1993
48
Inhibition of basal and corticotropin-releasing hormone-stimulated adenylate cyclase activity and cytosolic Ca2+ levels by somatostatin in human corticotropin-secreting pituitary adenomas. (1970828)
1990
49
Acromegalic gigantism with verified pituitary adenoma in a fourteen-year-old boy. (13229942)
1954
50
BASOPHIL ADENOMA OF THE PITUITARY GLAND WITH RENAL CHANGES. (20778876)
1935

Genetic Variations for Pituitary Adenoma

Expression for genes affiliated with Pituitary Adenoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pituitary Adenoma

Search GEO for disease gene expression data for Pituitary Adenoma.

Pathways for genes affiliated with Pituitary Adenoma

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 52QIAGEN, 12EMD Millipore
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Compounds for genes affiliated with Pituitary Adenoma

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB
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Compounds related to Pituitary Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 174)
idCompoundScoreTop Affiliating Genes
1octreotide45 60 29 1115.5SSTR3, SST, SSTR1, SSTR2, SSTR5, CHGA
2ribonucleic acid4512.3CGA, SSTR5, GH1, POMC, GHR, IGF1
3gnrh4512.2MKI67, POMC, IGF1, SST, SSTR2, CHGA
4acth4512.2SST, IGF1, POMC, GNAS, GNRH1, GHR
5arginine4512.1SST, IGF1, POMC, MKI67, AVPR1B, CHGA
6progesterone45 60 29 11 2416.0GH1, CGA, POMC, IGF1, SSTR2, GNAS
7testosterone45 60 11 2415.0CHGA, SST, CGA, GHR, GH1, IGF1
8lanreotide45 2913.0GHR, GH1, PRL, CHGA, SSTR5, SSTR2
9tamoxifen45 50 29 1115.0GH1, IGF1, SSTR2, CHGA, PRL, MKI67
10adenylate4511.9SSTR1, SST, SSTR2, POMC, CHGA, GH1
11dopamine45 29 11 2414.9IGF1, SSTR5, SSTR2, SSTR1, CHGA, GHR
12epinephrine45 11 2413.8MKI67, CHGA, POMC, SST, CGA, GAPDH
13norepinephrine45 11 2413.8PRL, CHGA, SST, GH1, GAPDH, GNAS
14clonidine45 29 1113.8POMC, IGF1, SST, CHGA, PRL, GH1
15thyroxine45 2412.7SST, POMC, IGF1, PRL, GH1, GHR
16cabergoline29 45 1113.7GHR, CGA, GNRH1, GH1, PRL, SST
17dehydroepiandrosterone sulfate4511.6PRL, GH1, GHR, CGA, GNRH1, POMC
18androstenedione45 2412.6GHR, CGA, POMC, PRL, GH1, GNRH1
19bromocriptine29 45 1113.6GNRH1, CGA, GHR, SST, POMC, PRL
20hexarelin45 2912.5PRL, SST, GH1, POMC, GHR, IGF1
21leuprolide acetate4511.5GNRH1, CGA, GHR, GH1, PRL, IGF1
22naloxone45 50 29 1114.5GH1, CGA, POMC, GNRH1, PRL, SST
23steroid4511.4GNAS, GNRH1, CGA, GHR, GH1, MKI67
24pasireotide45 1112.4SSTR2, SSTR1, SST, SSTR3, SSTR5
25(1r,1s,3r/1r,1r,3s)-l-054,2646011.4SSTR3, SST, SSTR1, SSTR2, SSTR5
26cyn 1548066011.4SSTR3, SST, SSTR2, SSTR5, SSTR1
27cyclosomatostatin6011.4SSTR3, SST, SSTR1, SSTR2, SSTR5
28somatostatin60 2412.4SSTR2, SST, SSTR3, SSTR5, SSTR1
29ghrp4511.4IGF1, PRL, GH1, GHR, SST
30buserelin45 29 1113.3GNRH1, IGF1, SST, PRL, CGA
31glucose4511.3GAPDH, SSTR2, POMC, IGF1
32som-2302911.2SSTR1, SSTR3, SSTR2, SSTR5
33ke 1082911.2SSTR3, SSTR5, SSTR2, SSTR1
34[125i]cgp 239962911.2SSTR3, SSTR1, SSTR2, SSTR5
35bim 230522911.2SSTR3, SSTR1, SSTR2, SSTR5
36111in-pentetreotide4511.2CHGA, SST, SSTR5
37cgp 239962911.2SSTR3, SSTR2, SSTR5, SSTR1
38l-362,8552911.2SSTR3, SSTR1, SSTR2, SSTR5
39[l-tyr8]cyn 1548062911.2SSTR3, SSTR1, SSTR2, SSTR5
40[d-tyr8]cyn 1548062911.2SSTR3, SSTR1, SSTR2, SSTR5
41bim 234542911.1SSTR2, SSTR1, SSTR3, SSTR5
42bim 236272911.1SSTR5, SSTR3, SSTR1, SSTR2
43cst-172911.1SSTR5, SSTR2, SSTR1, SSTR3
44[125i]tyr10-cst142911.1SSTR1, SSTR3, SSTR2, SSTR5
45[125i]ltt-srif-282911.0SSTR5, SSTR2, SSTR1, SSTR3
46quinagolide4511.0SST, IGF1, PRL, GH1
47naltrexone45 50 29 1114.0GNRH1, POMC, IGF1, PRL, GH1
48srif-282911.0SSTR5, SSTR2, SSTR1, SSTR3
49srif-142910.9SSTR5, SSTR2, SSTR1, SSTR3
50clomiphene citrate4510.7IGF1, GNRH1, CGA, GH1, PRL

GO Terms for genes affiliated with Pituitary Adenoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Pituitary Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.5POMC, GNAS, GNRH1, CGA, GHR, GH1
2plasma membraneGO:00588611.5AIP, GNAS, GAPDH, GHR, SSTR5, AVPR1B
3extracellular spaceGO:00561510.8GH1, POMC, IGF1, GHR, SST, GNRH1
4secretory granuleGO:03014110.7CHGA, POMC, PRL

Biological processes related to Pituitary Adenoma according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1cell-cell signalingGO:00726711.6SSTR2, GNRH1, CGA, SSTR1, SST, SSTR3
2negative regulation of cell proliferationGO:00828511.6SSTR3, SST, SSTR1, SSTR2, SSTR5, GNRH1
3G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718711.2SSTR1, SSTR2, SSTR3, SSTR5
4response to nutrientGO:00758411.2SSTR1, SST, PRL, SSTR2
5cellular response to estradiol stimulusGO:07139211.1SSTR3, SSTR2, SSTR1
6positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252311.1IGF1, GH1, GHR
7JAK-STAT cascade involved in growth hormone signaling pathwayGO:06039711.1GH1, GHR, PRL
8regulation of multicellular organism growthGO:04001411.1PRL, IGF1, GHR
9cerebellum developmentGO:02154911.1SSTR2, SSTR3, SSTR1
10response to starvationGO:04259411.1SSTR1, SSTR2, SSTR3
11digestionGO:00758611.0SSTR2, SST, SSTR1
12forebrain developmentGO:03090011.0SSTR1, SSTR2, SSTR3
13response to estradiol stimulusGO:03235511.0GHR, GH1, PRL
14positive regulation of peptidyl-tyrosine phosphorylationGO:05073111.0GHR, GH1, IGF1
15somatostatin signaling pathwayGO:03817011.0SSTR5, SSTR3
16hormone-mediated apoptotic signaling pathwayGO:00862810.9SST, SSTR3
17female pregnancyGO:00756510.9GNRH1, PRL, GNAS
18growth hormone receptor signaling pathwayGO:06039610.8GH1, GHR
19ovulation cycleGO:04269810.8GNRH1, PRL
20positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.7GH1, IGF1
21insulin-like growth factor receptor signaling pathwayGO:04800910.7GHR, IGF1
22positive regulation of JAK-STAT cascadeGO:04642710.6GH1, PRL
23cellular response to glucocorticoid stimulusGO:07138510.4SSTR3, SSTR2

Molecular functions related to Pituitary Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517911.1GNRH1, CGA, GH1, PRL, SST, IGF1
2prolactin receptor bindingGO:00514810.7GH1, PRL
3somatostatin receptor activityGO:00499410.6SSTR5, SSTR2, SSTR1, SSTR3

Products for genes affiliated with Pituitary Adenoma

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Sources for Pituitary Adenoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet