MCID: PTT006
MIFTS: 64

Pituitary Adenoma malady

Endocrine diseases category

Summaries for Pituitary Adenoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Pituitary adenomas are noncancerous tumors that occur in the pituitary gland. Pituitary adenomas are... more...

MalaCards: Pituitary Adenoma, also known as pituitary adenoma, no icd-o subtype, is related to adenoma and growth hormone secreting pituitary adenoma. An important gene associated with Pituitary Adenoma is AVPR1B (arginine vasopressin receptor 1B), and among its related pathways are Signaling by GPCR and Class A/1 (Rhodopsin-like receptors). The compounds octreotide and ribonucleic acid have been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and endothelial, and related mouse phenotypes are homeostasis/metabolism and nervous system.

Aliases & Classifications for Pituitary Adenoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

pituitary adenoma 8 10 44 60
pituitary adenoma, no icd-o subtype 8
adenoma of the pituitary gland 8
pituitary adenoma - disorder 8


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Disease Ontology8 DOID:3829
MeSH34 D010911
NCIt39 C3329

Related Diseases for Pituitary Adenoma

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17GeneCards, 18GeneDecks
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Diseases related to Pituitary Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 284)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma32.3CGA, GHR, MKI67, AVPR1B, GAPDH, GNRH1
2growth hormone secreting pituitary adenoma31.4AIP, RA9
3acromegaly31.1PRL, IGF1, SST, GH1
4acth-secreting pituitary adenoma31.1RA9, AIP
5pituitary apoplexy31.0GNRH1, POMC, PRL
6prolactinoma30.9AIP, RA9
7chromophobe adenoma30.9PRL, GH1
8thyroiditis30.9POMC, CGA
9meningioma30.9SST, MKI67, SSTR2, SSTR5, GAPDH
10craniopharyngioma30.8IGF1, GH1, POMC, PRL
11hypopituitarism30.7GNRH1, CGA, GHR, GH1, PRL, SST
12mccune albright syndrome30.7PRL, GH1, GNAS
13cushing's syndrome30.7POMC, SST, GH1
14hyperprolactinemia30.6GNRH1, GNAS, POMC, IGF1, SST, PRL
15adenocarcinoma30.5SST, SSTR2, CHGA, GAPDH, GHR, MKI67
16carney complex30.5POMC, AIP, GNAS
17pituitary cancer30.5PRL, POMC
18hypothyroidism30.5CGA, GNAS, GNRH1, IGF1, GHR, GH1
19prostate cancer30.5CHGA, GHR, GNRH1, MKI67, IGF1
20empty sella syndrome30.5PRL, POMC
21hyperthyroidism30.4IGF1, SST, PRL, GH1, GHR, CGA
22papillary carcinoma30.4SSTR2, GAPDH, CHGA, GNAS, MKI67
23paraganglioma30.4SST, CHGA, SSTR2
24sarcoma30.4SSTR2, MKI67, GAPDH
25pituitary tumors30.3GHR, GH1, CHGA, SSTR5, SSTR2, SSTR1
26neuroendocrine tumor30.3GNAS, GH1, SST, POMC, MKI67, SSTR2
27pheochromocytoma30.3CHGA, SST, SSTR5, SSTR2, SSTR1, GNAS
28parathyroid adenoma30.3GNAS, CHGA
29pituitary gland disease30.2CGA, GH1, PRL, IGF1
30graves' disease30.2CGA, GNAS
31leukemia30.2GHR, GAPDH
32adrenal adenoma30.2MKI67, CHGA, POMC
33insulinoma30.0GHR, SSTR5, CHGA, GH1, SSTR1, SSTR2
34hypoglycemia30.0SST, CHGA, IGF1, PRL, GH1, POMC
35hypogonadism30.0CGA, GH1, GNRH1, POMC, PRL, IGF1
36adrenal gland hyperfunction30.0SST, PRL, POMC, GH1, GHR
37panhypopituitarism30.0POMC, IGF1, GHR, PRL, GH1
38melanoma30.0SSTR2, MKI67, POMC, GHR, GAPDH
39anovulation30.0IGF1, GNRH1, CGA, PRL
40gynecomastia30.0GNRH1, CGA, PRL
41ovarian cyst30.0GNAS, GNRH1, CGA
42hyperparathyroidism29.9CHGA
43breast cancer29.9GNRH1, MKI67, SSTR2, CHGA, GAPDH
44leiomyoma29.9GNRH1, MKI67
45functioning pituitary adenoma11.0
46gangliocytoma10.5
47familial isolated pituitary adenoma10.5
48neuronitis10.5
49fetal adenoma10.4
50pregnancy adenoma10.4

Graphical network of the top 20 diseases related to Pituitary Adenoma:



Diseases related to pituitary adenoma

Clinical Features for Pituitary Adenoma

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Drugs & Therapeutics for Pituitary Adenoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Pituitary Adenoma

Genetic Tests for Pituitary Adenoma

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Anatomical Context for Pituitary Adenoma

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32MalaCards
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MalaCards organs/tissues related to Pituitary Adenoma:

32
Pituitary, Thyroid, Endothelial, Testes, Prostate, Bone, Ovary, Brain, Skin, B cells, Colon, Lung, Breast, Hypothalamus, Salivary gland, T cells, Monocytes, Kidney, Liver, Pons

Animal Models for Pituitary Adenoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pituitary Adenoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.3AVPR1B, GNAS, GNRH1, GAPDH, CGA, GHR
2MP:000363111.8GNAS, GNRH1, CGA, GHR, GH1, PRL
3MP:000537811.7GHR, CGA, GAPDH, GNRH1, GNAS, GH1
4MP:000538511.3GAPDH, GHR, CHGA, SSTR2, IGF1, AIP
5MP:000537011.2GNAS, GNRH1, GAPDH, GHR, GH1, PRL
6MP:000537911.0GHR, SSTR5, AIP, AVPR1B
7MP:000536710.9GNAS, GNRH1, GAPDH, GHR, CHGA, IGF1

Publications for Pituitary Adenoma

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50PubMed
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Articles related to Pituitary Adenoma:

(show top 50)    (show all 1538)
idTitleAuthorsYear
1
Melanoma of the sellar region mimicking pituitary adenoma. (22624497)
2013
2
Multiple melanonychia as a sign of pituitary adenoma. (23758550)
2013
3
Thyroid-stimulating hormone-secreting pituitary adenoma presenting with recurrent hyperthyroidism in post-treated Graves' disease: a case report. (23336522)
2013
4
Re: visual hallucinations (Charles Bonnet syndrome) as the presenting sign of pituitary adenoma. (23217505)
2012
5
A pituitary adenoma secreting follicle-stimulating hormone with ovarian hyperstimulation: treatment using a gonadotropin-releasing hormone antagonist. (22118994)
2012
6
Sellar collision tumor involving pituitary gonadotroph adenoma and chondroma: a potential clinical diagnosis. (19760170)
2011
7
No evidence of RET germline mutations in familial pituitary adenoma. (20956458)
2011
8
Complete biochemical control and pituitary adenoma disappearance in a child with gigantism: efficacy of octreotide therapy. (21502798)
2011
9
Prolactin-producing pituitary adenoma with abundant spherical amyloid deposition masquerading as extensive calcification. (21123991)
2010
10
O-methylguanine-DNA methyltransferase immunoexpression in a double pituitary adenoma: case report. (20087113)
2010
11
SIADH following pituitary adenoma apoplexy. (20119738)
2010
12
Cyclic Cushing syndrome due to an ectopic pituitary adenoma. (19107133)
2009
13
Mutations of the gene for the aryl hydrocarbon receptor-interacting protein in pituitary adenomas. (19188737)
2009
14
Lymphocytic hypophysitis occurring simultaneously with a functioning pituitary adenoma. (18497455)
2008
15
Medical therapy for clinically non-functioning pituitary adenomas. (18780796)
2008
16
Effect of somatostatin on repair of ionizing radiation-induced DNA damage in pituitary adenoma cells GH3. (17552875)
2008
17
Acromegaly in a patient with normal pituitary gland and somatotropic adenoma located in the sphenoid sinus. (18777506)
2008
18
B-RAF mutations are a rare event in pituitary adenomas. (17318013)
2007
19
Altered cyclin D1 genotype distribution in human sporadic pituitary adenomas. (17901853)
2007
20
Chemokine stromal cell-derived factor 1alpha induces proliferation and growth hormone release in GH4C1 rat pituitary adenoma cell line through multiple intracellular signals. (16258074)
2006
21
Concurrent lymphocytic hypophysitis and pituitary adenoma. Case report and review of the literature. (17219839)
2006
22
PTTG overexpression is correlated with angiogenesis in human pituitary adenomas. (17159247)
2006
23
Natural course of incidentally found nonfunctioning pituitary adenoma, with special reference to pituitary apoplexy during follow-up examination. (16776331)
2006
24
Results of transsphenoidal surgery in a large series of patients with pituitary adenoma. (15918938)
2005
25
Thyrotropin-producing pituitary adenoma associated with Graves' disease. (15538937)
2004
26
Expression of MMPPs and TIMP and invasiveness in pituitary adenomas]. (16114548)
2004
27
Genetic changes in human pituitary adenomas]. (12621361)
2003
28
New mechanisms involved in the pathogenesis of pituitary adenomas]. (12793085)
2003
29
Downregulation of E-cadherin and its undercoat proteins in pituitary growth hormone cell adenomas with prominent fibrous bodies. (12665652)
2002
30
Carney complex: report of a Japanese case associated with cutaneous superficial angiomyxomas, labial lentigines, and a pituitary adenoma. (12532046)
2002
31
Functional PPAR-gamma receptor is a novel therapeutic target for ACTH-secreting pituitary adenomas. (12379847)
2002
32
Loss of expression of GADD45 gamma, a growth inhibitory gene, in human pituitary adenomas: implications for tumorigenesis. (11889197)
2002
33
Topoisomerase IIalpha expression in pituitary adenomas and carcinomas: relationship to tumor behavior. (12429800)
2002
34
Surgical management of pituitary adenomas. (12380732)
2002
35
Leptin in pituitary adenomas--a novel paracrine regulatory system. (11824507)
2001
36
Pituitary adenoma associated with gigantism and hyperprolactinemia. (11786701)
2001
37
Loss of pRb expression in pituitary adenomas is associated with methylation of the RB1 CpG island. (10728677)
2000
38
Prolactin-producing pituitary adenoma and carcinoma with neuronal components--a metaplastic lesion. (11081198)
1999
39
Ultrastructural and immunoelectron microscopic study of three unusual plurihormonal pituitary adenomas. (10445280)
1999
40
Protein kinase C and growth regulation of pituitary adenomas. (8738488)
1996
41
An audit of selected patients with non-functioning pituitary adenoma treated by transsphenoidal surgery without irradiation. (7828355)
1994
42
Gonadotropin-releasing hormone induced Ca2+ influx in nonsecreting pituitary adenoma cells: role of voltage-dependent Ca2+ channels and protein kinase C. (7704445)
1994
43
Presence and characterization of the somatostatin precursor in normal human pituitaries and in growth hormone secreting adenomas. (8093621)
1993
44
Molecular screening of pituitary adenomas for gene mutations and rearrangements. (8100831)
1993
45
Human pituitary null cell adenomas and oncocytomas in vitro: effects of adenohypophysiotropic hormones and gonadal steroids on hormone secretion and tumor cell morphology. (1569159)
1992
46
Hypothalamic peptides modulate cytosolic free Ca2+ levels and adenylyl cyclase activity in human nonfunctioning pituitary adenomas. (1679762)
1991
47
Adenohypophysis hormone gene products in 14 pituitary adenomas: analysis by immunohistochemistry and northern blotting. (1713495)
1991
48
Patterns of gastrin secretion in patients with nonfunctioning pituitary adenomas. (1802924)
1991
49
Screening for multiple endocrine neoplasia type 1 in patients with recognized pituitary adenoma. (1982864)
1990
50
The chromophobe adenoma of the pituitary; an evaluation of its treatment of some case reports. (18869132)
1948

Genetic Variations for Pituitary Adenoma

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Expression for genes affiliated with Pituitary Adenoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pituitary Adenoma

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Pathways for genes affiliated with Pituitary Adenoma

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN, 12EMD Millipore
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Compounds for genes affiliated with Pituitary Adenoma

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Pituitary Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 174)
idCompoundScoreTop Affiliating Genes
1octreotide44 59 28 1115.5SSTR3, SST, SSTR1, SSTR2, SSTR5, CHGA
2ribonucleic acid4412.3CGA, SSTR5, GH1, POMC, GHR, IGF1
3gnrh4412.2MKI67, POMC, IGF1, SST, SSTR2, CHGA
4acth4412.2SST, IGF1, POMC, GNAS, GNRH1, GHR
5arginine4412.1SST, IGF1, POMC, MKI67, AVPR1B, CHGA
6progesterone44 59 28 11 2416.0GH1, CGA, POMC, IGF1, SSTR2, GNAS
7testosterone44 59 11 2415.0CHGA, SST, CGA, GHR, GH1, IGF1
8lanreotide44 2813.0GHR, GH1, PRL, CHGA, SSTR5, SSTR2
9tamoxifen44 49 28 1115.0GH1, IGF1, SSTR2, CHGA, PRL, MKI67
10adenylate4411.9SSTR1, SST, SSTR2, POMC, CHGA, GH1
11dopamine44 28 11 2414.9IGF1, SSTR5, SSTR2, SSTR1, CHGA, GHR
12epinephrine44 11 2413.8MKI67, CHGA, POMC, SST, CGA, GAPDH
13norepinephrine44 11 2413.8PRL, CHGA, SST, GH1, GAPDH, GNAS
14clonidine44 28 1113.8POMC, IGF1, SST, CHGA, PRL, GH1
15thyroxine44 2412.7SST, POMC, IGF1, PRL, GH1, GHR
16cabergoline28 44 1113.7GHR, CGA, GNRH1, GH1, PRL, SST
17dehydroepiandrosterone sulfate4411.6PRL, GH1, GHR, CGA, GNRH1, POMC
18androstenedione44 2412.6GHR, CGA, POMC, PRL, GH1, GNRH1
19bromocriptine28 44 1113.6GNRH1, CGA, GHR, SST, POMC, PRL
20hexarelin44 2812.5PRL, SST, GH1, POMC, GHR, IGF1
21leuprolide acetate4411.5GNRH1, CGA, GHR, GH1, PRL, IGF1
22naloxone44 49 28 1114.5GH1, CGA, POMC, GNRH1, PRL, SST
23steroid4411.4GNAS, GNRH1, CGA, GHR, GH1, MKI67
24pasireotide44 1112.4SSTR2, SSTR1, SST, SSTR3, SSTR5
25(1r,1s,3r/1r,1r,3s)-l-054,2645911.4SSTR3, SST, SSTR1, SSTR2, SSTR5
26cyn 1548065911.4SSTR3, SST, SSTR2, SSTR5, SSTR1
27cyclosomatostatin5911.4SSTR3, SST, SSTR1, SSTR2, SSTR5
28somatostatin59 2412.4SSTR2, SST, SSTR3, SSTR5, SSTR1
29ghrp4411.4IGF1, PRL, GH1, GHR, SST
30buserelin44 28 1113.3GNRH1, IGF1, SST, PRL, CGA
31glucose4411.3GAPDH, SSTR2, POMC, IGF1
32som-2302811.2SSTR1, SSTR3, SSTR2, SSTR5
33ke 1082811.2SSTR3, SSTR5, SSTR2, SSTR1
34[125i]cgp 239962811.2SSTR3, SSTR1, SSTR2, SSTR5
35bim 230522811.2SSTR3, SSTR1, SSTR2, SSTR5
36111in-pentetreotide4411.2CHGA, SST, SSTR5
37cgp 239962811.2SSTR3, SSTR2, SSTR5, SSTR1
38l-362,8552811.2SSTR3, SSTR1, SSTR2, SSTR5
39[l-tyr8]cyn 1548062811.2SSTR3, SSTR1, SSTR2, SSTR5
40[d-tyr8]cyn 1548062811.2SSTR3, SSTR1, SSTR2, SSTR5
41bim 234542811.1SSTR2, SSTR1, SSTR3, SSTR5
42bim 236272811.1SSTR5, SSTR3, SSTR1, SSTR2
43cst-172811.1SSTR5, SSTR2, SSTR1, SSTR3
44[125i]tyr10-cst142811.1SSTR1, SSTR3, SSTR2, SSTR5
45[125i]ltt-srif-282811.0SSTR5, SSTR2, SSTR1, SSTR3
46quinagolide4411.0SST, IGF1, PRL, GH1
47naltrexone44 49 28 1114.0GNRH1, POMC, IGF1, PRL, GH1
48srif-282811.0SSTR5, SSTR2, SSTR1, SSTR3
49srif-142810.9SSTR5, SSTR2, SSTR1, SSTR3
50clomiphene citrate4410.7IGF1, GNRH1, CGA, GH1, PRL

GO Terms for genes affiliated with Pituitary Adenoma

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16Gene Ontology
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Cellular components related to Pituitary Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.5POMC, GNAS, GNRH1, CGA, GHR, GH1
2plasma membraneGO:00588611.5GAPDH, GHR, SSTR5, SSTR2, SSTR1, SSTR3
3extracellular spaceGO:00561510.8GNRH1, GHR, GH1, SST, IGF1, POMC
4secretory granuleGO:03014110.7PRL, CHGA, POMC

Biological processes related to Pituitary Adenoma according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1cell-cell signalingGO:00726711.6POMC, GNRH1, CGA, SSTR2, SSTR1, SST
2negative regulation of cell proliferationGO:00828511.6GNRH1, SSTR5, SSTR2, SSTR1, SST, SSTR3
3G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718711.2SSTR5, SSTR2, SSTR1, SSTR3
4response to nutrientGO:00758411.2PRL, SSTR2, SSTR1, SST
5cellular response to estradiol stimulusGO:07139211.1SSTR3, SSTR1, SSTR2
6positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252311.1GHR, GH1, IGF1
7JAK-STAT cascade involved in growth hormone signaling pathwayGO:06039711.1PRL, GH1, GHR
8regulation of multicellular organism growthGO:04001411.1GHR, PRL, IGF1
9cerebellum developmentGO:02154911.1SSTR2, SSTR1, SSTR3
10response to starvationGO:04259411.1SSTR3, SSTR1, SSTR2
11digestionGO:00758611.0SST, SSTR1, SSTR2
12forebrain developmentGO:03090011.0SSTR3, SSTR1, SSTR2
13response to estradiol stimulusGO:03235511.0GHR, GH1, PRL
14positive regulation of peptidyl-tyrosine phosphorylationGO:05073111.0IGF1, GH1, GHR
15somatostatin signaling pathwayGO:03817011.0SSTR3, SSTR5
16hormone-mediated apoptotic signaling pathwayGO:00862810.9SST, SSTR3
17female pregnancyGO:00756510.9GNAS, GNRH1, PRL
18ovulation cycleGO:04269810.8PRL, GNRH1
19growth hormone receptor signaling pathwayGO:06039610.8GH1, GHR
20positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.7IGF1, GH1
21insulin-like growth factor receptor signaling pathwayGO:04800910.7IGF1, GHR
22positive regulation of JAK-STAT cascadeGO:04642710.6PRL, GH1
23cellular response to glucocorticoid stimulusGO:07138510.4SSTR3, SSTR2

Molecular functions related to Pituitary Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517911.1POMC, GNRH1, CGA, GH1, PRL, SST
2prolactin receptor bindingGO:00514810.7PRL, GH1
3somatostatin receptor activityGO:00499410.6SSTR3, SSTR1, SSTR2, SSTR5

Products for genes affiliated with Pituitary Adenoma

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Sources for Pituitary Adenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet