MCID: PTT006
MIFTS: 52

Pituitary Adenoma malady

Endocrine diseases category

Aliases & Classifications for Pituitary Adenoma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 61UMLS, 39NCIt, 33MeSH, 56SNOMED-CT
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Aliases & Descriptions for Pituitary Adenoma:

Name: Pituitary Adenoma 8 10 44 61
 
Adenoma of the Pituitary Gland 8


Classifications:



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Disease Ontology8 DOID:3829
NCIt39 C3329
MeSH33 D010911

Summaries for Pituitary Adenoma

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Wikipedia:64 Pituitary adenomas are tumors that occur in the pituitary gland. Pituitary adenomas are generally... more...

MalaCards based summary: Pituitary Adenoma, also known as adenoma of the pituitary gland, is related to chromophobe adenoma and pituitary apoplexy. An important gene associated with Pituitary Adenoma is AIP (aryl hydrocarbon receptor interacting protein), and among its related pathways are Hormone ligand-binding receptors and Salivary secretion. The compounds ghrp and buserelin have been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and endothelial, and related mouse phenotypes are tumorigenesis and adipose tissue.

Related Diseases for Pituitary Adenoma

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Diseases related to Pituitary Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 263)
idRelated DiseaseScoreTop Affiliating Genes
1chromophobe adenoma31.7GH1, PRL
2pituitary apoplexy31.5GNRH1, POMC, PRL
3cushing's syndrome31.2POMC, SST, GH1
4craniopharyngioma31.2IGF1, POMC, PRL, GH1
5empty sella syndrome31.1POMC, PRL
6ovarian hyperstimulation syndrome30.9GNRH1, CGA
7paraganglioma30.9SSTR2, SST, CHGA
8acth-independent macronodular adrenal hyperplasia30.8GNAS
9gigantism30.8AIP, IGF1, GNAS, PRL, SST, GH1
10pituitary carcinoma30.7POMC, PRL
11multiple endocrine neoplasia30.7GNAS, CHGA, PRKAR1A
12mccune-albright syndrome, somatic, mosaic30.6GNAS, PRL, GH1
13gynecomastia30.4CGA, PRL, GNRH1
14fibrous dysplasia30.4GH1, GHR, GNAS
15ovarian cyst30.4GNAS, GNRH1, CGA
16growth hormone deficiency30.4IGF1, POMC, PRL, GHR, GH1
17leiomyoma30.3ADM, GNRH1, MKI67
18anovulation30.2IGF1, GNRH1, PRL, CGA
19prostate cancer30.2IGF1, MKI67, GNRH1, CHGA, GHR
20hyperprolactinemia30.2POMC, PRL, SST, GH1, CGA, GNRH1
21hypopituitarism30.2IGF1, GNRH1, POMC, PRL, SST, GHR
22neuroendocrine tumor30.1MKI67, GNAS, POMC, CHGA, SST, SSTR2
23hypothyroidism29.9IGF1, GNAS, GNRH1, POMC, PRL, GHR
24multiple endocrine neoplasia 129.9AIP, CHGA, PRKAR1A, SST
25breast cancer29.9MKI67, GNRH1, CHGA, SSTR2, GAPDH
26hypogonadism29.8IGF1, GNRH1, POMC, PRL, GH1, CGA
27melanoma29.8MKI67, POMC, SSTR2, GHR, GAPDH
28pheochromocytoma29.8GNAS, POMC, ADM, CHGA, SSTR5, SSTR1
29hyperthyroidism29.8IGF1, GNAS, ADM, PRL, SST, GHR
30obesity29.8IGF1, GNAS, POMC, GHR, GH1, GAPDH
31adenocarcinoma29.8MKI67, ADM, CHGA, SSTR1, SST, SSTR2
32adrenal gland hyperfunction29.6POMC, PRL, PRKAR1A, SST, GHR, GH1
33acromegaly29.5AIP, GH1, GHR, IGF1, GNAS, GNRH1
34adenoma29.4IGF1, MKI67, GNAS, GNRH1, POMC, CHGA
35hypoglycemia29.3GH1, GHR, SST, PRL, CHGA, POMC
36insulinoma28.9SSTR1, SST, SSTR2, SSTR3, GHR, GH1
37pituitary tumors28.5AIP, IGF1, GNAS, GNRH1, POMC, CHGA
38prolactinoma28.3SSTR2, SSTR3, GH1, GAPDH, CGA, SST
39functioning pituitary adenoma11.0
40non-functioning pituitary adenoma11.0
41familial isolated pituitary adenoma10.8
42thyroiditis10.7
43gangliocytoma10.6
44aneurysm10.6
45endotheliitis10.6
46pituitary adenoma, growth hormone-secreting10.5
47endogenous depression10.5POMC
48pituitary adenoma, acth-secreting10.5
49neuronitis10.5
50headache10.5

Graphical network of the top 20 diseases related to Pituitary Adenoma:



Diseases related to pituitary adenoma

Symptoms for Pituitary Adenoma

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Drugs & Therapeutics for Pituitary Adenoma

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Drug clinical trials:

Search ClinicalTrials for Pituitary Adenoma

Search NIH Clinical Center for Pituitary Adenoma

Genetic Tests for Pituitary Adenoma

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Anatomical Context for Pituitary Adenoma

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MalaCards organs/tissues related to Pituitary Adenoma:

31
Pituitary, Thyroid, Endothelial, Bone, Prostate, Testes, Brain, Breast, B cells, Bone marrow, Colon, Kidney, Liver, Lung, Salivary gland, Skin, Ovary, Monocytes, T cells, Hypothalamus, Pons

Animal Models for Pituitary Adenoma or affiliated genes

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Publications for Pituitary Adenoma

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Articles related to Pituitary Adenoma:

(show top 50)    (show all 1416)
idTitleAuthorsYear
1
Ectopic ACTH-secreting pituitary adenoma of the sphenoid sinus: case report of endoscopic endonasal resection and systematic review of the literature. (25639312)
2015
2
Unusual case of Cowden-like syndrome, neck paraganglioma, and pituitary adenoma. (23804288)
2014
3
Treatment protocols for growth hormone-secreting pituitary adenomas combined with craniofacial fibrous dysplasia: A case report of atypical McCune-Albright syndrome. (25120617)
2014
4
Analysis of operative efficacy for giant pituitary adenoma. (25163653)
2014
5
Medical management of functioning pituitary adenoma: an update. (25446388)
2014
6
Melanoma of the sellar region mimicking pituitary adenoma. (22624497)
2013
7
mTOR is frequently active in GH-secreting pituitary adenomas without influencing their morphopathological features. (23296986)
2013
8
Somatotroph pituitary adenoma with acromegaly and autosomal dominant polycystic kidney disease: SSTR5 polymorphism and PKD1 mutation. (21744088)
2012
9
Radiation-associated sarcoma of the skull base after irradiation for pituitary adenoma. (22532923)
2012
10
Mutation and genomic amplification of the PIK3CA proto-oncogene in pituitary adenomas. (22782554)
2012
11
Glucocorticoid replacement and mortality in patients with nonfunctioning pituitary adenoma. (22872686)
2012
12
Spontaneous cerebrospinal fluid rhinorrhea as the initial presentation of growth hormone-secreting pituitary adenoma. (20888068)
2011
13
An ACTH-secreting pituitary adenoma within the sphenoid sinus. (20424367)
2010
14
Down-regulation of Wee1 kinase by a specific subset of microRNA in human sporadic pituitary adenomas. (20668041)
2010
15
Differential gene expression by fiber-optic beadarray and pathway in adrenocorticotrophin-secreting pituitary adenomas. (22166531)
2010
16
Immunohistochemical expression of pituitary tumor transforming gene (PTTG) in pituitary adenomas: a correlative study of tumor subtypes. (20106827)
2010
17
Familial isolated pituitary adenoma: evidence for genetic heterogeneity. (20616498)
2010
18
Use of morning serum cortisol level after transsphenoidal resection of pituitary adenoma to predict the need for long-term glucocorticoid supplementation. (19326985)
2009
19
Younger age is a good predictor of better executive function after surgery for pituitary adenoma in adults. (19638252)
2009
20
Extensive spherical amyloid deposition of pituitary adenoma presenting as pituitary apoplexy. (18280642)
2008
21
Expression of MSX1 in human normal pituitaries and pituitary adenomas. (18379900)
2008
22
Ghrelin stimulates adrenocorticotrophic hormone (ACTH) secretion by human ACTH-secreting pituitary adenomas in vitro. (17280594)
2007
23
Pituitary tumour transforming gene (PTTG) expression correlates with the proliferative activity and recurrence status of pituitary adenomas: a clinical and immunohistochemical study. (16984249)
2006
24
An unusual somatotropin and thyreotropin secreting pituitary adenoma efficiently controlled by Octreotide and Pegvisomant. (16840917)
2006
25
The effect of selective sst1, sst2, sst5 somatostatin receptors agonists, a somatostatin/dopamine (SST/DA) chimera and bromocriptine on the "clinically non-functioning" pituitary adenomas in vitro. (16115652)
2006
26
Chemokine stromal cell-derived factor 1alpha induces proliferation and growth hormone release in GH4C1 rat pituitary adenoma cell line through multiple intracellular signals. (16258074)
2006
27
Effectiveness of treating ovarian hyperstimulation syndrome with cabergoline in two patients with gonadotropin-producing pituitary adenomas. (16952513)
2006
28
Thyroid color flow Doppler sonography: an adjunctive tool for differentiating patients with inappropriate thyrotropin (TSH) secretion due to TSH-secreting pituitary adenoma or resistance to thyroid hormone. (17042684)
2006
29
Immunohistochemical staining of cathepsins B, L and stefin A in human hypophysis and pituitary adenomas. (15816632)
2005
30
Non-functioning pituitary adenomas: clinical features and immunohistochemistry]. (16400431)
2005
31
Prolactin-producing pituitary adenoma with incomplete neuronal transformation: an intermediate adenoma-neuronal tumor. (15173951)
2004
32
Chromogranin A in pituitary adenomas: immunohistochemical detection and plasma concentrations. (15704652)
2004
33
Preoperative lanreotide treatment for GH-secreting pituitary adenomas: effect on tumour volume and predictive factors of significant tumour shrinkage. (12641631)
2003
34
Preliminary study of p16 gene expression in pituitary adenomas]. (12600300)
2003
35
Gamma knife radiosurgery for pituitary adenoma. (12487277)
2002
36
Genesis of pituitary adenomas: state of the art. (11761437)
2001
37
Non-random trisomies of chromosomes 5, 8 and 12 in the prolactinoma sub-type of pituitary adenomas: conventional cytogenetics and interphase FISH study. (10760821)
2000
38
Expression of P27kip1 and Ki-67 in pituitary adenomas: an investigation of marker of adenoma invasiveness. (10189502)
1999
39
Expression of the members of the Ptx family of transcription factors in human pituitary adenomas. (10372733)
1999
40
Expression of an orphan nuclear receptor DAX-1 in human pituitary adenomas. (9666878)
1998
41
A case of non-functioning pituitary adenoma accompanied by a large cyst. (9638270)
1998
42
Plasma chromogranin A in pheochromocytoma, primary hyperparathyroidism and pituitary adenoma in comparison with catecholamine, parathyroid hormone and pituitary hormones. (9228469)
1997
43
Immunohistochemical detection of human natural killer cell like immunoreactivity in human pituitary adenomas, using monoclonal antibody NK-1. (9266438)
1997
44
Pancreastatin secretion by pituitary adenomas and regulation of chromogranin B mRNA expression. (8669489)
1996
45
Interleukin-2 (IL-2) and IL-6 regulate c-fos protooncogene expression in human pituitary adenoma explants. (9027322)
1996
46
Effects of long-term treatment with the gonadotropin-releasing hormone analog nafarelin in patients with non-functioning pituitary adenomas. (8162161)
1994
47
Prolactin-producing pituitary adenoma in a male-to-female transsexual patient with protracted estrogen administration. A morphologic study. (8192565)
1994
48
Pulsatile thyrotropin and prolactin secretion in a patient with a mixed thyrotropin- and prolactin-secreting pituitary adenoma. (8130883)
1994
49
Clinical application of 11C-NMSP to the patients with pituitary adenoma other than prolactinoma]. (8345693)
1993
50
Pituitary adenomas of patients with acromegaly express thyrotropin- releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene. (8396925)
1993

Variations for Pituitary Adenoma

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Expression for genes affiliated with Pituitary Adenoma

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Search GEO for disease gene expression data for Pituitary Adenoma.

Pathways for genes affiliated with Pituitary Adenoma

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Pathways related to Pituitary Adenoma according to GeneCards Suite gene sharing:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9GNRH1, CGA
2
Show member pathways
9.8GNAS, SST, SSTR2
39.8GNAS, PRKAR1A
4
Show member pathways
Transcription Receptor mediated HIF regulation59
Development CNTF receptor signaling59
Class IB PI3K non-lipid kinase events36
ErbB2/ErbB3 signaling events36
Development Growth hormone signaling via PI3K AKT and MAPK cascades59
Translation Regulation activity of EIF259
Regulation of lipid metabolism Insulin signaling generic cascades59
Transcription PPAR Pathway59
Cell adhesion PLAU signaling59
Translation Regulation activity of EIF4F59
9.8GNAS, PRKAR1A
5
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling59
Leptin signaling pathway36
9.7PRL, GH1, CGA
69.7CGA, PRL, POMC
79.6GH1, GHR, PRL
8
Show member pathways
9.6GH1, GHR, PRL
9
Show member pathways
Type III interferon signaling36
9.6PRL, GHR, GH1
109.6IGF1, GNAS, CGA
119.5IGF1, GHR, GH1
12
Show member pathways
Apoptosis and survival BAD phosphorylation59
Development Alpha 2 adrenergic receptor activation of ERK59
Chemotaxis CXCR4 signaling pathway59
9.4PRKAR1A, GNAS, IGF1
13
Show member pathways
Development Ligand independent activation of ESR1 and ESR259
9.4GNAS, PRKAR1A, IGF1
149.3GH1, IGF1, PRL, GHR
15
Show member pathways
9.3POMC, IGF1, GH1, CGA
16
Show member pathways
Cytoskeleton remodeling FAK signaling59
Development Endothelin 1 EDNRA transactivation of EGFR59
9.3GNAS, GNRH1, CGA, IGF1
17
Show member pathways
9.2PRKAR1A, POMC, CGA, GNAS
18
Show member pathways
9.1GNRH1, IGF1, PRKAR1A, GH1
19
Show member pathways
9.1GNRH1, PRKAR1A, IGF1, GH1
209.1ADM, POMC, CGA, GNAS
21
Show member pathways
9.0GNRH1, GH1, IGF1, PRL, GHR
22
Show member pathways
8.8IGF1, PRL, PRKAR1A, GHR, GH1
238.1PRKAR1A, SSTR1, SSTR2, GAPDH, SST
24
Show member pathways
6.0SSTR3, GNAS, GHR, GH1, CGA, SST
25
Show member pathways
5.2POMC, ADM, PRL, PRKAR1A, SSTR5, SSTR1

Compounds for genes affiliated with Pituitary Adenoma

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Compounds related to Pituitary Adenoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 220)
idCompoundScoreTop Affiliating Genes
1ghrp449.4GH1, GHR, SST, PRL, IGF1
2buserelin44 28 1111.4PRL, IGF1, CGA, SST, GNRH1
3quinagolide449.4PRL, SST, GH1, IGF1
4naltrexone44 28 50 1112.3IGF1, GNRH1, POMC, GH1, PRL
5clomiphene citrate449.3GNRH1, IGF1, GH1, CGA, PRL
6naloxone44 28 50 1112.2PRL, CGA, GNRH1, POMC, SST, GH1
7hexarelin44 2810.2IGF1, POMC, GH1, GHR, SST, PRL
8leuprolide acetate449.1GH1, GNRH1, IGF1, PRL, CGA, GHR
9som-230289.0SSTR5, SSTR1, SSTR3, SSTR2
10111in-pentetreotide449.0CHGA, SSTR2, SSTR5, SST, SSTR1
11cabergoline44 28 1110.9PRL, GNRH1, SST, GHR, GH1, CGA
12pasireotide44 119.9SST, SSTR1, SSTR2, SSTR3, SSTR5
13ke 108288.9SSTR5, SSTR1, SSTR2, SSTR3
14cyn 154806608.9SSTR2, SSTR3, SST, SSTR1, SSTR5
15cyclosomatostatin608.9SSTR3, SSTR2, SST, SSTR1, SSTR5
16(1r,1s,3r/1r,1r,3s)-l-054,264608.9SSTR3, SSTR2, SST, SSTR1, SSTR5
17[125i]cgp 23996288.8SSTR1, SSTR3, SSTR2, SSTR5
18somatostatin60 249.8SST, SSTR3, SSTR2, SSTR1, SSTR5
19bim 23627288.8SSTR3, SSTR2, SSTR1, SSTR5
20dehydroepiandrosterone sulfate448.8POMC, GH1, GHR, PRL, IGF1, GNRH1
21bim 23454288.8SSTR3, SSTR2, SSTR1, SSTR5
22androstenedione44 249.7GNRH1, IGF1, POMC, GH1, CGA, GHR
23cgp 23996288.7SSTR5, SSTR3, SSTR2, SSTR1
24bim 23052288.7SSTR3, SSTR2, SSTR1, SSTR5
25bromocriptine44 28 1110.6CGA, GH1, GHR, SST, PRL, POMC
26thyroxine44 249.5PRL, GH1, GHR, CGA, IGF1, GNRH1
27clonidine44 50 28 1111.5IGF1, POMC, CHGA, PRL, SST, GHR
28cst-17288.4SSTR3, SSTR2, SSTR1, SSTR5
29acetylcholine44 50 28 24 1111.8GNRH1, ADM, CGA, CHGA, SST, GH1
30norepinephrine44 24 119.5GH1, GAPDH, CGA, SST, PRL, GNAS
31epinephrine44 24 119.5MKI67, GNRH1, POMC, ADM, CHGA, PRL
32gnrh447.5CHGA, PRL, SST, SSTR2, GHR, GH1
33dexamethasone44 50 28 1110.4GNRH1, GH1, IGF1, POMC, ADM, CHGA
34paraffin447.3MKI67, CGA, ADM, CHGA, SSTR1, POMC
35creatinine447.3CGA, GAPDH, GNRH1, GH1, GHR, IGF1
36acth447.3GH1, GHR, SSTR2, SST, GNRH1, GNAS
37lanreotide44 288.3GH1, GHR, SSTR3, SSTR2, SST, SSTR1
38vegf447.3CGA, SSTR2, SST, ADM, CHGA, GH1
39cycloheximide447.2ADM, IGF1, MKI67, POMC, CGA, GAPDH
40progesterone44 28 60 24 1111.1IGF1, MKI67, GNAS, GNRH1, POMC, PRL
41tamoxifen44 50 28 1110.1CGA, IGF1, MKI67, GAPDH, GH1, GHR
42steroid446.9MKI67, POMC, ADM, CHGA, PRL, PRKAR1A
43testosterone44 60 24 119.8CGA, GAPDH, GH1, IGF1, MKI67, GNRH1
44estrogen446.7IGF1, CGA, GAPDH, GH1, GHR, SSTR2
45arginine446.7IGF1, MKI67, GNAS, GNRH1, POMC, ADM
46ribonucleic acid446.3PRL, SSTR5, SSTR1, SSTR2, GHR, GH1
47adenylate446.2GNAS, GNRH1, POMC, ADM, PRKAR1A, SSTR1
48dopamine44 28 24 119.1CHGA, PRL, SSTR5, SSTR1, SST, SSTR2
49glucose445.6CHGA, SST, SSTR2, GHR, GH1, GAPDH
50octreotide44 60 28 118.6GNRH1, GNAS, MKI67, IGF1, CHGA, PRL

GO Terms for genes affiliated with Pituitary Adenoma

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Cellular components related to Pituitary Adenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.1IGF1, GNRH1, POMC, ADM, SST, GHR
2extracellular regionGO:00055767.0CGA, IGF1, GNAS, GNRH1, POMC, ADM
3cytoplasmGO:00057376.8MKI67, GNAS, POMC, ADM, SSTR1, SSTR2
4plasma membraneGO:00058866.2AIP, IGF1, GNAS, PRKAR1A, SSTR5, SSTR1

Biological processes related to Pituitary Adenoma according to GeneCards Suite gene sharing:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1growth hormone receptor signaling pathwayGO:006039610.1GHR, GH1
2somatostatin signaling pathwayGO:003817010.0SSTR5, SSTR3
3positive regulation of insulin-like growth factor receptor signaling pathwayGO:004356810.0IGF1, GH1
4hormone-mediated apoptotic signaling pathwayGO:000862810.0SST, SSTR3
5JAK-STAT cascade involved in growth hormone signaling pathwayGO:006039710.0GHR, GH1, PRL
6positive regulation of JAK-STAT cascadeGO:00464279.9PRL, GH1
7positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.9GHR, GH1, IGF1
8regulation of multicellular organism growthGO:00400149.9IGF1, GHR, PRL
9cAMP biosynthetic processGO:00061719.9GNAS, ADM
10cellular response to glucocorticoid stimulusGO:00713859.8SSTR2, SSTR3
11insulin-like growth factor receptor signaling pathwayGO:00480099.8IGF1, GHR
12positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.8GH1, GHR, IGF1
13regulation of insulin secretionGO:00507969.7SSTR5, GNAS, PRKAR1A
14developmental growthGO:00485899.7ADM, GNAS, CGA
15peptide hormone processingGO:00164869.6POMC, CGA
16female pregnancyGO:00075659.5GNAS, PRL, GNRH1, ADM
17digestionGO:00075869.5SST, SSTR2, SSTR1
18response to nutrientGO:00075849.4SSTR1, SST, SSTR2
19cellular response to estradiol stimulusGO:00713929.3SSTR3, SSTR1, SSTR2
20cell surface receptor signaling pathwayGO:00071669.2PRL, SSTR1, SST
21cerebellum developmentGO:00215499.2SSTR2, SSTR3, SSTR1
22forebrain developmentGO:00309009.2SSTR1, SSTR3, SSTR2
23G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00071879.1SSTR1, SSTR5, SSTR3, SSTR2
24response to starvationGO:00425948.7SSTR1, SSTR2, SSTR3, ADM
25signal transductionGO:00071658.4GNRH1, POMC, ADM, AIP, PRKAR1A, CGA
26negative regulation of cell proliferationGO:00082857.7GNRH1, ADM, SSTR5, SSTR1, SST, SSTR2
27cell-cell signalingGO:00072677.6POMC, CGA, SSTR3, SST, SSTR1, SSTR2

Molecular functions related to Pituitary Adenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1prolactin receptor bindingGO:000514810.0GH1, PRL
2somatostatin receptor activityGO:00049948.6SSTR5, SSTR1, SSTR2, SSTR3
3hormone activityGO:00051798.0CGA, IGF1, GNRH1, POMC, ADM, PRL
4protein bindingGO:00055155.6AIP, IGF1, MKI67, GNAS, ADM, PRL

Sources for Pituitary Adenoma

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet