MCID: PTT048
MIFTS: 50

Pituitary Adenoma, Prolactin-Secreting malady

Categories: Genetic diseases, Rare diseases, Reproductive diseases, Endocrine diseases, Cancer diseases

Aliases & Classifications for Pituitary Adenoma, Prolactin-Secreting

About this section
Sources:
11Disease Ontology, 12diseasecard, 13DISEASES, 26GTR, 30ICD10 via Orphanet, 36MedGen, 38MeSH, 39MESH via Orphanet, 44NCIt, 47NIH Rare Diseases, 49Novoseek, 51OMIM, 53Orphanet, 61SNOMED-CT, 67UMLS, 68UMLS via Orphanet, 69UniProtKB/Swiss-Prot
See all MalaCards sources

Aliases & Descriptions for Pituitary Adenoma, Prolactin-Secreting:

Name: Pituitary Adenoma, Prolactin-Secreting 51 11 12
Prolactinoma 11 47 53 69 49 38 13 67
Prolactin-Secreting Pituitary Adenoma 47 53 69
Prl-Secreting Pituitary Adenoma 47 53
Pituitary Lactotrophic Adenoma 47 53
Familial Prolactinoma 11 26
 
Lactotroph Adenoma 47 53
Prloma 47 53
Prolactin-Producing Pituitary Gland Adenoma 47
Prolactinoma of Pituitary Gland 11
Pspa 69

Characteristics:

Orphanet epidemiological data:

53
prolactinoma:
Inheritance: Not applicable; Prevalence: 1-5/10000 (United Kingdom),6-9/10000 (Belgium),1-5/10000 (Switzerland),1-9/100000 (Malta); Age of onset: Adolescent,Adult,Childhood,Elderly; Age of death: normal life expectancy

Classifications:



External Ids:

OMIM51 600634
Disease Ontology11 DOID:5394
MeSH38 D015175
NCIt44 C3342
Orphanet53 ORPHA2965
MESH via Orphanet39 D015175
UMLS via Orphanet68 C0033375
ICD10 via Orphanet30 D35.2, E22.1
MedGen36 C0033375

Summaries for Pituitary Adenoma, Prolactin-Secreting

About this section
OMIM:51 Prolactin-secreting pituitary adenoma, or prolactinoma, is the most common type of hormonally active pituitary adenoma.... (600634) more...

MalaCards based summary: Pituitary Adenoma, Prolactin-Secreting, also known as prolactinoma, is related to prolactin producing pituitary tumor and hyperprolactinemia, and has symptoms including Array, Array and Array. An important gene associated with Pituitary Adenoma, Prolactin-Secreting is AIP (Aryl Hydrocarbon Receptor Interacting Protein), and among its related pathways are Transcription_CREM signaling in testis and SIDS Susceptibility Pathways. Affiliated tissues include pituitary and t cells, and related mouse phenotypes are liver/biliary system and adipose tissue.

UniProtKB/Swiss-Prot:69 Prolactin-secreting pituitary adenoma: Most common type of hormonally active pituitary adenoma.

Related Diseases for Pituitary Adenoma, Prolactin-Secreting

About this section

Diseases related to Pituitary Adenoma, Prolactin-Secreting via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1prolactin producing pituitary tumor29.8AIP, DRD2, IGF1, MEN1, PRKAR1A, PRL
2hyperprolactinemia11.2
3lethal arteriopathy syndrome due to fibulin-4 deficiency10.7AIP, MEN1
4medich giant platelet syndrome10.7AIP, MEN1
5genetic lipodystrophy10.6PRL, TRH
6pearson syndrome10.5MEN1, SST
7erysipelas10.5DRD2, PRL
8isolated levocardia10.5MEN1, SST
9brain angioma10.5POMC, SST
10malignant granular cell skin tumor10.5POMC, TRH
11lung large cell carcinoma10.5SST, SSTR2
12lactic acidosis10.5POMC, PRL
13colloid carcinoma of the pancreas10.4POMC, PRL
14retinal microaneurysm10.4AIP, POMC, PRL
15prosopagnosia10.4POMC, SST
16postpartum depression10.4POMC, PRL
17autoimmune oophoritis10.4GH1, POMC
18bardet-biedl syndrome10.4POMC, PRL, TRH
19strabismus10.4DRD2, PRL, SST
20pituitary deficiency due to rathke's pouch cysts10.4GH1, SST
21als2-related disorders10.4AIP, GNAS
2210.4POMC, SST
23hypothalamic neoplasm10.4POMC, PRL, TRH
24acute myeloid leukemia, kit-related10.4POMC, PRL, TRH
25symmastia10.4DRD2, PRL
26lipid-rich carcinoma10.4POMC, PRL, SST
27benign paroxysmal positional nystagmus10.3POMC, PRL, TRH
28ovarian mucinous malignant adenofibroma10.3GH1, PRL, SST
29avoidant personality disorder10.3DRD2, POMC, PRL
30glaucoma iridogoniodysgenesia10.3AIP, IGF1, SST
31ossifying fibroma10.3SST, SSTR2, SSTR5
32endocrine gland cancer10.3MEN1, SST, SSTR2
33carcinoma of the vocal tract10.3IGF1, MEN1, SST
34pneumonia10.3
35immune system organ benign neoplasm10.3IGF1, POMC, PRL
36diabetes insipidus10.2IGF1, POMC, PRL
37dental pulp necrosis10.2IGF1, POMC, PRL
38hidradenitis10.2IGF1, POMC, PRL
39morphine dependence10.2DRD2, IGF1, POMC
40fibrosclerosis of breast10.2IGF1, PRL
41mobitz type ii atrioventricular block10.2AIP, POMC, PRL, SST
42echolalia10.2GNAS, PRL, TRH
43patellofemoral pain syndrome10.2IGF1, POMC, SST
44onychotrichodysplasia and neutropenia10.2SSTR1, SSTR5
45primary progressive multiple sclerosis10.2MEN1, SST
46adrenal carcinoma10.2POMC, PRL, SST, TRH
47adenoma10.1
48femoral neuropathy10.1IGF1, POMC, SST
49fumarate hydratase deficiency10.1GH1, GNAS, PRL
50ehlers-danlos syndrome, type viii10.1AIP, MEN1, PRKAR1A, PRL

Graphical network of the top 20 diseases related to Pituitary Adenoma, Prolactin-Secreting:



Diseases related to pituitary adenoma, prolactin-secreting

Symptoms for Pituitary Adenoma, Prolactin-Secreting

About this section

Symptoms by clinical synopsis from OMIM:

600634

Clinical features from OMIM:

600634

Human phenotypes related to Pituitary Adenoma, Prolactin-Secreting:

 53 63 (show all 52)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 male hypogonadism53 Very frequent (99-80%)
2 hypogonadotrophic hypogonadism53 Very frequent (99-80%)
3 amenorrhea53 Very frequent (99-80%)
4 female hypogonadism53 Very frequent (99-80%)
5 hypogonadism53 Very frequent (99-80%)
6 abnormality of the menstrual cycle53 Very frequent (99-80%)
7 ptosis53 Occasional (29-5%)
8 progressive visual loss53 Frequent (79-30%)
9 blindness53 Occasional (29-5%)
10 diplopia53 Occasional (29-5%)
11 gynecomastia53 Frequent (79-30%)
12 impotence53 Very frequent (99-80%)
13 delayed puberty53 Occasional (29-5%)
14 anterior hypopituitarism53 Occasional (29-5%)
15 growth hormone excess53 Occasional (29-5%)
16 menstrual irregularities53 Very frequent (99-80%)
17 decreased fertility in females53 Very frequent (99-80%)
18 osteopenia53 Frequent (79-30%)
19 osteoporosis53 Frequent (79-30%)
20 pallor53 Frequent (79-30%)
21 sudden central visual loss53 Occasional (29-5%)
22 seizures53 Occasional (29-5%)
23 headache53 Frequent (79-30%)
24 cranial nerve paralysis53 Occasional (29-5%)
25 vomiting53 Frequent (79-30%)
26 nausea and vomiting53 Frequent (79-30%)
27 vertigo53 Occasional (29-5%)
28 hypotension53 Frequent (79-30%)
29 decreased circulating acth level53 Frequent (79-30%)
30 low gonadotropins (secondary hypogonadism)53 Very frequent (99-80%)
31 easy fatigability53 Frequent (79-30%)
32 cranial nerve vi palsy53 Occasional (29-5%)
33 fourth cranial nerve palsy53 Occasional (29-5%)
34 internal ophthalmoplegia53 Occasional (29-5%)
35 secondary growth hormone deficiency53 Frequent (79-30%)
36 pituitary hypothyroidism53 Frequent (79-30%)
37 abnormality of hair density53 Frequent (79-30%)
38 central adrenal insufficiency53 Frequent (79-30%)
39 adrenocorticotropin (acth) deficient adrenal insufficiency53 Frequent (79-30%)
40 adrenocorticotropic hormone deficiency53 Frequent (79-30%)
41 decreased fertility in males53 Very frequent (99-80%)
42 oculomotor nerve palsy53 Occasional (29-5%)
43 hemianopsia53 Occasional (29-5%)
44 fatigue53 Frequent (79-30%)
45 abnormality of the pituitary gland53 Very frequent (99-80%)
46 decreased female libido53 Very frequent (99-80%)
47 dyspareunia53 Frequent (79-30%)
48 heteronymous hemianopia53 Occasional (29-5%)
49 bitemporal hemianopia53 Occasional (29-5%)
50 erectile abnormalities53 Very frequent (99-80%)
51 galactorrhea53 Very frequent (99-80%)
52 pituitary prolactin cell adenoma63 HP:0006767

Drugs & Therapeutics for Pituitary Adenoma, Prolactin-Secreting

About this section

Drugs for Pituitary Adenoma, Prolactin-Secreting (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
DopamineapprovedPhase 4, Phase 2, Phase 3375951-61-6, 62-31-7681
Synonyms:
(3H)-Dopamine
.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane
1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)
1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride
1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium
153C5321-5FEE-4B0B-8925-F388F0EEEBD1
2-(3,4-Dihydroxyphenyl)ethylamine
2-(3,4-dihydroxyphenyl)ethylamine
2-benzenediol
3,4-Dihydroxyphenethylamine
3,4-Dihydroxyphenethylamine hydrochloride
3,4-Dihydroxyphenylethylamine
3,4-dihydroxyphenethylamine
3-Hydroxtyramine
3-Hydroxytyramine
3-Hydroxytyramine Hydrobromide
3-Hydroxytyramine hydrochloride
4-(2-Aminoethyl)-1,
4-(2-Aminoethyl)-1,2-benzenediol
4-(2-Aminoethyl)-1,2-bezenediol
4-(2-Aminoethyl)-Pyrocatechol
4-(2-Aminoethyl)benzene-1,2-diol
4-(2-Aminoethyl)catechol
4-(2-Aminoethyl)pyrocatechol
4-(2-Aminoethyl)pyrocatechol hydrochloride
4-(2-aminoethyl)-pyrocatechol
50444-17-2
51-61-6
62-31-7 (HYDROCHLORIDE)
AC1L19S5
AC1Q54AX
AC1Q54AY
AKOS003790978
ASL 279
BIDD:ER0506
BPBio1_001123
BSPBio_001932
Biomol-NT_000001
C03758
CHEBI:18243
CHEMBL59
CID681
D07870
DB00988
Deoxyepinephrine
DivK1c_000780
Dopamin
Dopamina
Dopamina [INN-Spanish]
Dopamine
Dopamine (INN)
Dopamine (USAN)(*hydrochloride*)
Dopamine [INN:BAN]
Dopaminum
Dopaminum [INN-Latin]
Dopastat
Dophamine
Dynatra
EINECS 200-110-0
HSDB 3068
Hydroxytyramin
Hydroxytyramine
IDI1_000780
IP 498
Intropin
Intropin [*hydrochloride*]
KBio1_000780
 
KBio2_001492
KBio2_002388
KBio2_002484
KBio2_004060
KBio2_004956
KBio2_005052
KBio2_006628
KBio2_007524
KBio2_007620
KBio3_001152
KBio3_002867
KBio3_002962
KBioGR_001129
KBioGR_002388
KBioGR_002484
KBioSS_001492
KBioSS_002393
KBioSS_002491
KW-3-060
L-DOPAMINE
L000232
LDP
LS-159
Lopac-H-8502
Lopac0_000586
Medopa (TN)
MolPort-001-641-000
NCGC00015519-01
NCGC00015519-08
NCGC00096050-01
NCGC00096050-02
NCGC00096050-03
NCGC00096050-04
NCGC00096050-05
NINDS_000780
NSC 173182
NSC169105
NSC173182
Oprea1_088821
Oxytyramine
Pyrocatechol, 4-(2-aminoethyl)- (8CI)
Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride
Revimine
Revivan
SPBio_001205
SPECTRUM1505155
ST048774
STK301601
Spectrum2_001023
Spectrum3_000406
Spectrum4_000525
Spectrum5_000945
Spectrum_001012
UNII-VTD58H1Z2X
UPCMLD0ENAT5885989:001
a-(3,4-Dihydroxyphenyl)-b-aminoethane
alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane
cMAP_000036
cMAP_000065
dopamine
hydroxytyramine
intropin
m-Hydroxytyramine hydrochloride
nchembio.105-comp9
nchembio.107-comp4
nchembio.284-comp1
nchembio.78-comp16
nchembio.89-comp3
nchembio705-8
nchembio801-comp8
2
CabergolineapprovedPhase 4, Phase 2, Phase 34681409-90-754746
Synonyms:
(8R)-6-Allyl-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)ergoline-8-carboxamide
(8R)-6-allyl-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)ergoline-8-carboxamide
(8beta)-N-[3-(dimethylamino)Propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-ergoline-8-carboxamide
(8beta)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-6-(prop-2-en-1-yl)ergoline-8-carboxamide
(8beta)-N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-ergoline-8-carboxamide
(8beta)-N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-prop-2-en-1-ylergoline-8-carboxamide
1-((6-Allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea
1-Ethyl-3-(3'-dimethylamionpropyl)-2-(6'-allylergoline-8'beta-carbonyl)urea
1-[(6-Allylergoline-8beta-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea
1-[(6-allylergoline-8beta-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea
1-ethyl-2-(3'-dimethylaminopropyl)-3-(6'-allylergoline-8'-beta-carbonyl)urea diphosphate
1-ethyl-3-(3'-dimethylamionpropyl)-2-(6'-allylergoline-8'beta-carbonyl)urea
81409-90-7
85329-89-1 (diphosphate)
AC-14150
AC1L1HO0
AC1Q5OQ0
BIDD:GT0775
BRD-K86882815-001-01-6
BRN 6020775
C08187
C26H37N5O2
CG-101
CHEBI:3286
 
CHEMBL1201087
CID54746
Cabaser
Cabaser (TN)
Cabaseril
Cabergolina
Cabergolina [Spanish]
Cabergoline
Cabergoline (JAN/USAN/INN)
Cabergoline [USAN:BAN:INN]
Cabergolinum
Cabergolinum [Latin]
D00987
DB00248
Dostinex
Dostinex (TN)
FCE-21336
FT-0081285
Galastop
HMS2090A09
LS-64370
MolPort-003-845-557
Sogilen
UNII-LL60K9J05T
cabergoline
3Antiparkinson AgentsPhase 4, Phase 2, Phase 31527
4Neurotransmitter AgentsPhase 4, Phase 2, Phase 317734
5Dopamine agonistsPhase 4, Phase 2, Phase 3618
6Dopamine AgentsPhase 4, Phase 2, Phase 33759
7
SomatostatinapprovedPhase 2, Phase 322938916-34-6, 51110-01-153481605
Synonyms:
growth hormone-inhibiting hormone (GHIH)
 
somatotropin release-inhibiting factor (SRIF)
somatotropin release-inhibiting hormone
8Peripheral Nervous System AgentsPhase 2, Phase 3, Phase 122776
9HormonesPhase 2, Phase 3, Phase 113979
10Protective AgentsPhase 2, Phase 37190
11Hormone AntagonistsPhase 2, Phase 3, Phase 112778
12Autonomic AgentsPhase 2, Phase 3, Phase 19774
13Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 2, Phase 3, Phase 112767
14
Bromocriptineapproved, investigationalPhase 23125614-03-331101
Synonyms:
(5'alpha)-2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-3',6',18-trioxoergotaman
(5'alpha)-2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)ergotaman-3',6',18-trione
(5'alpha)-2-bromo-12'-hydroxy-5'-(2-methylpropyl)-2'-(propan-2-yl)-3',6',18-trioxoergotaman
(5'alpha)-2-bromo-12'-hydroxy-5'-isobutyl-2'-isopropyl-3',6',18-trioxoergotaman
(6aR,9R)-5-Bromo-N-((2R,5S,10aS,10bS)-10b-hydroxy-5-isobutyl-2-isopropyl-3,6-dioxooctahydro-2H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
2-Bromo-12'-hydroxy-2'-(1-methylethyl)-5'-alpha-(2-methylpropyl)ergotamin-3',6',18-trione
2-Bromo-alpha-ergocryptine
2-Bromo-alpha-ergokryptin
2-Bromo-alpha-ergokryptine
2-Bromoergocryptine Methanesulfonate
2-Bromoergokryptine
2-bromo-α-ergocryptine
2-bromo-α-ergokryptin
2-bromo-α-ergokryptine
22260-51-1 (mesylate (salt))
25614-03-3
AC-13601
AC1L1KXS
AC1Q2716
Alti-Bromocriptine
Apo-Bromocriptine
BIDD:GT0464
BPBio1_001131
BRD-K14496212-001-01-1
Bagren
Biomol-NT_000005
Bromergocryptine
Bromocriptin
Bromocriptina
Bromocriptina [INN-Spanish]
Bromocriptine (USAN/INN)
Bromocriptine Methanesulfonate
Bromocriptine [BAN]
Bromocriptine [USAN:BAN:INN]
 
Bromocriptine methanesulfonate
Bromocriptinum
Bromocriptinum [INN-Latin]
Bromocryptin
Bromocryptine
Bromoergocriptine
Bromoergocryptine
C06856
C32H40BrN5O5
CB-154
CCRIS 3244
CHEBI:3181
CHEMBL493
CID31101
D03165
DB01200
EINECS 247-128-5
Ergocryptine, 2-bromo- (8CI)
Ergoset
LS-64540
Lopac0_000171
MolPort-002-512-064
NCGC00024584-04
NCI60_001365
NSC169774
PDSP2_001500
Parlodel
Parlodel Snaptabs
Prestwick0_000121
Prestwick1_000121
Prestwick2_000121
SPBio_002101
UNII-3A64E3G5ZO
bromocriptine
nchembio873-comp18
15
EnclomipheneinvestigationalPhase 216215690-57-0
Synonyms:
 
Clomiphene trans-form
16
Lapatinibapproved, investigational, Approved March 2007Phase 2296231277-92-2, 388082-78-8208908, 9941095
Synonyms:
1xkk
231277-92-2
388082-78-8
4-[[3-Chloro-4-(3-fluorobenzyloxy)phenyl]amino]-6-[5-[[(2-methanesulfonylethyl)amino]methyl]furan-2-yl]quinazoline
AB1004631
AC-1314
AC1L4LL4
AKOS005145766
CHEBI:49603
CHEMBL1201179
CHEMBL554
CID11557040
CID208908
D04024
D08108
DB01259
DB02584
EN002712
FMM
GSK 572016
GSK572016
GW 572016
GW 572016X
GW-2016
GW-572016
GW-572016F
GW2016
GW572016
HMS2089H10
I01-1247
 
Kinome_3684
Kinome_3685
LAPATINIB DITOSYLATE MONOHYDRATE
LS-187029
LS-187771
Lapatinib
Lapatinib (INN)
Lapatinib Ditosylate
Lapatinib [INN]
Lapatinib ditosylate
Lapatinib ditosylate (USAN)
Lapatinib tosilate hydrate
Lapatinib tosilate hydrate (JAN)
Lapatinib, Tykerb, GW572016
N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-((2-methylsulfonylethylamino)methyl)-2-furyl)quinazolin-4-amine
N-(3-Chloro-4-{[(3-fluorophenyl)methyl]oxy}phenyl)-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furanyl]-4-quinazolinamine
N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine
N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine
N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE
N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine
NCGC00167507-01
NSC745750
TL80090051
Tycerb
Tykerb
Tykerb (TN)
Tyverb
UNII-0VUA21238F
lapatinib
lapatinib ditosylate
nchembio866-comp20
17Selective Estrogen Receptor ModulatorsPhase 2586
18ClomiphenePhase 2162
19Fertility AgentsPhase 2493
20ZuclomiphenePhase 2162
21Estrogen AntagonistsPhase 21315
22Estrogen Receptor ModulatorsPhase 2630
23EstrogensPhase 22470
24Protein Kinase InhibitorsPhase 23612
25CitrateNutraceuticalPhase 21106
26
Citric Acidnutraceutical, vet_approvedPhase 2110677-92-9311
Synonyms:
2-Hydroxy-1,2,3-propanetricarboxylate
2-Hydroxy-1,2,3-propanetricarboxylic acid
2-Hydroxytricarballylic acid
3-Carboxy-3-hydroxypentane-1,5-dioate
3-Carboxy-3-hydroxypentane-1,5-dioic acid
Aciletten
Anhydrous citrate
Anhydrous citric acid
Chemfill
Citraclean
 
Citrate
Citretten
Citric acid
Citro
Citronensäure
E 330
Hydrocerol A
Kyselina citronova
Suby G
Uro-trainer
beta-Hydroxytricarballylate
beta-Hydroxytricarballylic acid
27
Dexamethasoneapproved, investigational, vet_approvedPhase 1208450-02-25743
Synonyms:
(3H)-Dexamethasone
.delta.(sup 1)-9-.alpha.-Fluoro-16-.alpha.-methylcortisol
.gamma.corten
1-Dehydro-16.alpha.-methyl-9.alpha.-fluorohydrocortisone
1-Dehydro-16alpha -methyl-9alpha -fluorohydrocortisone
1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone
1-Dehydro-16α-methyl-9α-fluorohydrocortisone
137098-19-2
16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol
16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone
16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone
16-alpha-Methyl-9-alpha-fluoroprednisolone
16.alpha.-Methyl-9.alpha.-fluoro-1-dehydrocortisol
16.alpha.-Methyl-9.alpha.-fluoroprednisolone
16alpha -Methyl-9alpha -fluoro-1-dehydrocortisol
16alpha -Methyl-9alpha -fluoroprednisolone
16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol
16alpha-Methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone
16alpha-Methyl-9alpha-fluoroprednisolone
16α-Methyl-9α-fluoro-1-dehydrocortisol
23495-06-9
31375_FLUKA
46165_FLUKA
46165_RIEDEL
50-02-2
8054-59-9
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11alpha -methylpregna-1,4-diene-3,20-dione
9-Fluoro-16-methylprednisolone
9-alpha-Fluoro-16-alpha-methylprednisolone
9.alpha.-Fluoro-16.alpha.-methylprednisolone
906422-84-2
9A-FLUORO-16BETA-METHYLPREDNISOLONE
9alpha -Fluoro-16alpha -methylprednisolone
9alpha-Fluoro-16alpha-methylprednisolone
9alpha-fluoro-16alpha-methyl-Prednisolone
9α-Fluoro-16α-methylprednisolone
AC-11056
AC1L1L1H
AC1Q29DM
AI3-50934
Adexone
Aeroseb-D
Aeroseb-Dex
Aeroseb-dex
Ak Dex Oph Otic Soln 0.1%
Alcon Brand of Dexamethasone
Anaflogistico
Aphtasolon
Aphthasolone
Apo-dexamethasone
Auxiron
Azimycin (veterinary)
Azium
Azium (Veterinary)
Azium (veterinary)
BIDD:ER0494
BIDD:PXR0060
BRD-K38775274-001-02-3
BRD-K38775274-001-06-4
BSPBio_000995
Bisu DS
Bisu Ds
C15643
C22H29FO5
CCRIS 7067
CHEBI:41879
CHEMBL384467
CID5743
CPD-10549
CPD001227192
Calonat
Corson
Corsone
Cortisumman
D00292
D003907
D1756_SIGMA
D4902_SIGMA
D6645_SIGMA
D8893_SIGMA
D9184_SIGMA
DB01234
DEX
DEXA
DEXONE 0.5
DEXONE 0.75
DEXONE 1.5
DEXONE 4
DXM
DXMS
Decacort
Decacortin
Decaderm
Decadron
Decadron (TN)
Decadron Tablets, Elixir
Decadron, Dexamethasone
Decadron-LA
Decadron-La
Decagel
Decaject
Decaject L.A.
Decaject-L.A.
Decalix
Decameth
Decasone
Decaspray
Dectancyl
Dekacort
Delta1-9alpha-Fluoro-16alpha-methylcortisol
Deltafluorene
Dergramin
Deronil
Desadrene
Desametasone
Desametasone [DCIT]
Desametasone [Dcit]
Desamethasone
Desameton
Deseronil
Dex-Ide
Dex-ide
Dexa
Dexa Mamallet
Dexa mamallet
Dexa-Cortidelt
Dexa-Cortisyl
Dexa-Mamallet
Dexa-Scheroson
Dexa-Sine
Dexa-cortidelt
Dexa-cortisyl
Dexa-scheroson
Dexa-sine
Dexacen-4
Dexacidin
Dexacort
Dexacortal
Dexacortin
Dexadeltone
Dexafarma
Dexair
Dexalona
Dexaltin
Dexametasona
Dexametasona [INN-Spanish]
Dexametasone
 
Dexameth
Dexamethansone
Dexamethasone
Dexamethasone (JP15/USP/INN)
Dexamethasone Acetate
Dexamethasone Alcohol
Dexamethasone Base
Dexamethasone Intensol
Dexamethasone Sodium Phosphate
Dexamethasone [INN:BAN:JAN]
Dexamethasone alcohol
Dexamethasone base
Dexamethasone intensol
Dexamethasone-omega
Dexamethasonum
Dexamethasonum [INN-Latin]
Dexamethazone
Dexamonozon
Dexapolcort
Dexapos
Dexaprol
Dexason
Dexasone
Dexasone 0.5mg
Dexasone 0.75mg
Dexasone 4mg
Dexasporin
Dexinolon
Dexinoral
Dexone
Dexone 0.5
Dexone 0.75
Dexone 1.5
Dexone 4
Dexonium
Dexpak
Dextelan
Dezone
Dinormon
Dxms
ECR Brand of Dexamethasone
EINECS 200-003-9
FT-0080377
Fluormethylprednisolone
Fluormone
Fluorocort
Fortecortin
Foy Brand of Dexamethasone
Gammacorten
HL-dex
HMS1792A17
HMS1990A17
HMS2089N13
HSDB 3053
Hexadecadrol
Hexadrol
Hexadrol Elixir
Hexadrol Tablets
Hexadrol elixir
Hl-Dex
Hl-dex
I06-1196
ICN Brand of Dexamethasone
IontoDex
Isopto-Dex
Isopto-dex
LS-7300
Lokalison F
Lokalison f
Loverine
Luxazone
MK 125
MLS001055412
MLS001332507
MLS001332508
Maxidex
Maxidex Ont 0.1%
Maxidex Sus 0.1%
Maxitrol
Mediamethasone
Merck Brand of Dexamethasone
Merz Brand 1 of Dexamethasone
Merz Brand 2 of Dexamethasone
Methylfluorprednisolone
Mexidex
Millicorten
MolMap_000018
MolPort-003-846-433
Mymethasone
NCGC00091019-01
NCGC00091019-02
NCGC00091019-03
NCGC00091019-04
NCGC00091019-05
NCI60_003067
NSC 34521
NSC34521
Naquasone (veterinary)
Neomycin and polymyxin b sulfates and dexamethasone
Neomycin and polymyxin b sulphates and dexamethasone
OTO-104
Ocu-Trol
Ocu-trol
Oradexon
PHL-dexamethasone
PMS-dexamethasone
Pet Derm III
Pet Derm Iii
Pet derm III
Pet-Derm Iii
Pms Dexamethasone Elixir 0.5mg/5ml
Policort
Posurdex
Prednisolon F
Prednisolon f
Prednisolone F
Prednisolone f
Prodex
S1322_Selleck
SAM002548948
SGCUT00126
SK-Dexamethasone
SK-dexamethasone
SMP1_000092
SMR000857119
SMR001227192
ST50307091
Sandoz dexamethasone
Sk-Dexamethasone
Spectrum5_002019
Spoloven
Sunia Sol D
Sunia sol D
Superprednol
TL8003317
Tobradex
Tobramycin and dexamethasone
Tresaderm (veterinary)
Turbinaire
UNII-7S5I7G3JQL
Visumetazone
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ G1
ZINC03875332
alpha -Fluoro-16-alpha -methylcortisol
delta(Sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta1-9alpha-Fluoro-16alpha-methylcortisol
dexamethasone
nchembio809-comp2
to_000038
28Antirheumatic AgentsPhase 110627
29Turmeric extractPhase 166
30
CurcuminPhase 1137458-37-7969516
Synonyms:
1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
1,9-Bis(4-hydroxy-3-methoxyphenyl)-2,7-nonadiene-4,6-dione
C.I. Natural Yellow 3
CI Natural Yellow 3
Cucurmin
Curcuma
Curcumin
Curcumin I
Diferaloylmethane
Diferuloylmethane
Gelbwurz
Golden seal
Haidr
Halad
Haldar
Halud
Hydrastis
 
Indian saffron
Indian turmeric
Kacha haldi
Kurkumin [czech]
Merita earth
Natural yellow 3
Orange root
Safran D'inde
Souchet
Terra merita
Tumeric yellow
Turmeric
Turmeric (>98% curcurmin)
Turmeric oleoresin (79%-85% curcumin)
Turmeric yellow
Yellow ginger
Yellow puccoon
Yellow root
Yo-kin
Zlut prirodni 3 [Czech]
31AnalgesicsPhase 111287
32Analgesics, Non-NarcoticPhase 16260
33Anti-Inflammatory Agents, Non-SteroidalPhase 14295
34Anti-Inflammatory AgentsPhase 110355
35Gastrointestinal AgentsPhase 18109
36HIV Protease InhibitorsPhase 15319
37
protease inhibitorsPhase 15320
Synonyms:
 
protease inhibitors
38Dexamethasone acetatePhase 120841177-87-3
39glucocorticoidsPhase 14920
40Dexamethasone 21-phosphatePhase 12084
41AntiemeticsPhase 13888
42Antineoplastic Agents, HormonalPhase 15407
43BB 1101Phase 12084
44TurmericNutraceuticalPhase 174
45Insulin, Globin Zinc4523
46insulin4524
47Hypoglycemic Agents5733

Interventional clinical trials:

(show all 17)
idNameStatusNCT IDPhase
1Cardiac Valve Complications in Prolactinomas Treated With CabergolineCompletedNCT00460616Phase 4
2Response to Cabergoline and Pasireotide in Non-functioning Pituitary Adenomas and Resistant ProlactinomasCompletedNCT01620138Phase 2, Phase 3
3Clomiphene in Males With Prolactinomas and Persistent HypogonadismCompletedNCT00697814Phase 2
4Targeted Therapy With Lapatinib in Patients With Recurrent Pituitary Tumors Resistant to Standard TherapyRecruitingNCT00939523Phase 2
5Bromocriptine Quick Release (BCQR) as Adjunct Therapy in Type 1 DiabetesRecruitingNCT02544321Phase 2
6Temozolomide in Treating Patients With Invasive Pituitary TumorsWithdrawnNCT00601289Phase 2
7Turmeric Effect on Reduction of Serum Prolactin and Related Hormonal Change and Adenoma Size in Prolactinoma PatientsUnknown statusNCT01344291Phase 1
8Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell LeukemiaTerminatedNCT01088763Phase 1
9Efficacy of Rapid Escalation of Cabergoline in Comparison to Conventional Dosing in Prolactin Secreting Macroadenomas.Unknown statusNCT01143584
10Prevalence of Pituitary Incidentaloma in Relatives of Patients With Pituitary AdenomaUnknown statusNCT00598949
11Aryl Hydrocarbon Receptor Interacting Protein (AIP) Gene Mutations in AcromegalyUnknown statusNCT01902420
12Insulin Resistance in Women With ProlactinomaCompletedNCT00481299
13Dopamine Agonists Withdrawal Study of Invasive Prolactinomas Involving the Cavernous SinusRecruitingNCT02536261
14Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPARecruitingNCT00461188
15Interdisciplinary Pituitary Disorders Centre of Excellence: Assessment of Patient Education ToolsRecruitingNCT01775332
16PITUItary Carcinoma or Aggressive Tumors REgistry -LyonRecruitingNCT02854228
17Rhinological Outcomes in Endonasal Pituitary SurgeryActive, not recruitingNCT01504399

Search NIH Clinical Center for Pituitary Adenoma, Prolactin-Secreting


Cochrane evidence based reviews: prolactinoma

Genetic Tests for Pituitary Adenoma, Prolactin-Secreting

About this section

Genetic tests related to Pituitary Adenoma, Prolactin-Secreting:

id Genetic test Affiliating Genes
1 Prolactinoma, Familial26

Anatomical Context for Pituitary Adenoma, Prolactin-Secreting

About this section

MalaCards organs/tissues related to Pituitary Adenoma, Prolactin-Secreting:

35
Pituitary, T cells

Animal Models for Pituitary Adenoma, Prolactin-Secreting or affiliated genes

About this section

MGI Mouse Phenotypes related to Pituitary Adenoma, Prolactin-Secreting:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.5AIP, DRD2, GNAS, MEN1, POMC, PRL
2MP:00053758.7DRD2, GHSR, GNAS, IGF1, POMC, PRKAR1A
3MP:00020068.6AIP, DRD2, GNAS, IGF1, MEN1, POMC
4MP:00053858.5AIP, DRD2, GNAS, IGF1, MEN1, POMC
5MP:00053867.4DRD2, GHSR, GNAS, POMC, PRL, SST
6MP:00053797.3AIP, DRD2, GNAS, IGF1, MEN1, POMC
7MP:00036317.1DRD2, GNAS, IGF1, MEN1, POMC, PRL
8MP:00053786.6AIP, DRD2, GHSR, GNAS, IGF1, MEN1
9MP:00053765.4AIP, DRD2, GHSR, GNAS, IGF1, MEN1

Publications for Pituitary Adenoma, Prolactin-Secreting

About this section

Variations for Pituitary Adenoma, Prolactin-Secreting

About this section

Clinvar genetic disease variations for Pituitary Adenoma, Prolactin-Secreting:

5
id Gene Variation Type Significance SNP ID Assembly Location
1AIPNM_003977.3(AIP): c.40C> T (p.Gln14Ter)SNVPathogenicrs104894194GRCh37Chr 11, 67250669: 67250669

Cosmic variations for Pituitary Adenoma, Prolactin-Secreting:

8
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1COSM27887GNASpituitary,NS,adenoma,GHc.601C>Tp.R201C19
2COSM27888GNASpituitary,NS,adenoma,GHc.680A>Tp.Q227L19
3COSM27896GNASpituitary,NS,adenoma,GHc.680A>Gp.Q227R19
4COSM27899GNASpituitary,NS,adenoma,GHc.601C>Ap.R201S19
5COSM27895GNASpituitary,NS,adenoma,GHc.602G>Ap.R201H19
6COSM483HRASpituitary,NS,adenoma,GHc.35G>Tp.G12V19
7COSM482HRASpituitary,NS,adenoma,PRLc.34G>Cp.G12R19
8COSM760PIK3CApituitary,NS,adenoma,PRLc.1624G>Ap.E542K19
9COSM771PIK3CApituitary,NS,adenoma,PRLc.3073A>Gp.T1025A19

Expression for genes affiliated with Pituitary Adenoma, Prolactin-Secreting

About this section
Search GEO for disease gene expression data for Pituitary Adenoma, Prolactin-Secreting.

Pathways for genes affiliated with Pituitary Adenoma, Prolactin-Secreting

About this section

GO Terms for genes affiliated with Pituitary Adenoma, Prolactin-Secreting

About this section

Cellular components related to Pituitary Adenoma, Prolactin-Secreting according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuron projectionGO:00430058.9GHSR, SSTR1, SSTR2, SSTR5
2plasma membraneGO:00058866.2AIP, DRD2, GHSR, GNAS, IGF1, SSTR1

Biological processes related to Pituitary Adenoma, Prolactin-Secreting according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1JAK-STAT cascade involved in growth hormone signaling pathwayGO:006039710.4GH1, PRL
2positive regulation of JAK-STAT cascadeGO:004642710.3GH1, PRL
3positive regulation of tyrosine phosphorylation of Stat5 proteinGO:004252310.2GH1, IGF1
4decidualizationGO:004669710.1GHSR, MEN1
5somatostatin signaling pathwayGO:003817010.1SSTR1, SSTR2, SSTR5
6peristalsisGO:00304329.9DRD2, SSTR2
7digestionGO:00075869.8SST, SSTR1, SSTR2
8neuropeptide signaling pathwayGO:00072189.8POMC, SSTR1, SSTR2
9positive regulation of insulin-like growth factor receptor signaling pathwayGO:00435689.7GH1, GHSR, IGF1
10cellular response to estradiol stimulusGO:00713929.7IGF1, SSTR1, SSTR2
11G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00071879.5SSTR1, SSTR2, SSTR5
12response to nutrientGO:00075849.4IGF1, SST, SSTR1, SSTR2
13forebrain developmentGO:00309009.3DRD2, SSTR1, SSTR2
14chemical synaptic transmissionGO:00072689.3SST, SSTR1, SSTR2, SSTR5
15cell-cell signalingGO:00072679.1POMC, SST, SSTR1, SSTR2, TRH
16positive regulation of multicellular organism growthGO:00400188.9DRD2, GH1, GHSR
17negative regulation of cell proliferationGO:00082858.6DRD2, MEN1, SST, SSTR1, SSTR2, SSTR5
18G-protein coupled receptor signaling pathwayGO:00071867.3DRD2, GHSR, SST, SSTR1, SSTR2, SSTR5

Molecular functions related to Pituitary Adenoma, Prolactin-Secreting according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1prolactin receptor bindingGO:000514810.4GH1, PRL
2insulin-like growth factor receptor bindingGO:00051599.9GNAS, IGF1
3somatostatin receptor activityGO:00049949.9SSTR1, SSTR2, SSTR5
4neuropeptide bindingGO:00429239.8SSTR1, SSTR2, SSTR5
5hormone activityGO:00051798.8GH1, IGF1, POMC, PRL, SST

Sources for Pituitary Adenoma, Prolactin-Secreting

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet