MCID: PTT004
MIFTS: 48

Pituitary Apoplexy malady

Endocrine category

Summaries for Pituitary Apoplexy

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Pituitary apoplexy or pituitary tumor apoplexy is bleeding into or impaired blood supply of the... more...

MalaCards: Pituitary Apoplexy is related to acromegaly and adenoma. An important gene associated with Pituitary Apoplexy is GNRH1 (gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)), and among its related pathways are Glycoprotein hormones and Development Prolactin receptor signaling. The compounds dopamine and leuprolide acetate have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and lung, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Aliases & Classifications for Pituitary Apoplexy

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 35MeSH, 40NCIt, 57SNOMED-CT, 36MESH via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine


Characteristics (Orphanet epidemiological data):

49
pituitary apoplexy:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

pituitary apoplexy 8 10 45 49 61


External Ids:

Disease Ontology8 DOID:1129
MeSH35 D010899
NCIt40 C26853
MESH via Orphanet36 D010899
SNOMED-CT57 237701005
SNOMED-CT via Orphanet58 237701005
UMLS via Orphanet62 C0032001
ICD10 via Orphanet26 E23.0

Related Diseases for Pituitary Apoplexy

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pituitary Apoplexy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 181)
idRelated DiseaseScoreTop Affiliating Genes
1acromegaly31.2GNRH1, GH1, PRL, TRH, POMC, INS
2adenoma31.1GNRH1, GH1, PRL, TRH, POMC, INS
3blindness30.8INS
4diabetes insipidus30.8PRL, TRH, POMC, AVP
5prolactinoma30.7GNRH1, GH1, PRL, TRH, POMC
6panhypopituitarism30.5GH1, PRL, POMC, AVP
7empty sella syndrome30.5GH1, PRL
8thyrotoxicosis30.5INS, TRH
9thyroiditis30.5TRH, POMC
10cushing's syndrome30.3GH1, POMC
11pituitary tumors30.3GNRH1, GH1, PRL, TRH, POMC
12amenorrhea30.3GNRH1, PRL, TRH, POMC, INS
13gigantism30.1PRL, GH1
14chromophobe adenoma30.1GH1, PRL
15growth hormone deficiency30.1INS, POMC, PRL, GH1
16hypoglycemia30.1GNRH1, GH1, PRL, TRH, POMC, INS
17headache10.4
18carotid artery occlusion10.3
19adenocarcinoma10.3
20bacterial meningitis10.3
21thrombocytopenia10.3
22hemorrhage, intracerebral10.3
23dengue hemorrhagic fever10.2
24meningoencephalitis10.2
25lymphocytic hypophysitis10.2
26thunderclap headache10.2
27hemorrhagic fever10.2
28head injury10.2
29angina pectoris10.1
30intracranial vasospasm10.1
31hellp syndrome10.1
32carotid stenosis10.1
33prostatic adenoma10.1
34status epilepticus10.1
35diabetic ketoacidosis10.1
36androgen insensitivity syndrome10.1
37central nervous system lymphoma10.1
38acute myeloid leukemia10.1
39aseptic meningitis10.1
40middle cerebral artery infarction10.1
41small cell carcinoma10.1
42intracranial aneurysm10.1
43carotid artery dissection10.1
44abdominal aortic aneurysm10.1
45suprasellar meningioma10.1
46n syndrome10.1
47acute leukemia10.1
48horner's syndrome10.1
49amblyopia10.1
50aortic aneurysm10.1

Graphical network of the top 20 diseases related to Pituitary Apoplexy:



Diseases related to pituitary apoplexy

Clinical Features for Pituitary Apoplexy

Drugs & Therapeutics for Pituitary Apoplexy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pituitary Apoplexy

Drug clinical trials:

Search ClinicalTrials for Pituitary Apoplexy

Search NIH Clinical Center for Pituitary Apoplexy

Search CenterWatch for Pituitary Apoplexy

Genetic Tests for Pituitary Apoplexy

Anatomical Context for Pituitary Apoplexy

Sources:
33MalaCards
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MalaCards organs/tissues related to Pituitary Apoplexy:

33
Liver, Brain, Lung, Heart, Thyroid, Adrenal gland, Prostate, Myeloid, B cells, Temporal lobe, Pituitary

Animal Models for Pituitary Apoplexy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Pituitary Apoplexy

Sources:
51PubMed
See all sources

Articles related to Pituitary Apoplexy:

(show top 50)    (show all 483)
idTitleAuthorsYear
1
Complex visual illusions in a patient with pituitary apoplexy. (23174459)
2013
2
Idiopathic granulomatous hypophysitis presenting as pituitary apoplexy. (24071055)
2013
3
Sudden death in custody due to pituitary apoplexy during long restriction in a sitting position: a case report and review of the literature. (24112326)
2013
4
Bromocriptine or cabergoline induced pituitary apoplexy: Rare but life-threatening catastrophe. (21772748)
2011
5
Visual vignette. Pituitary apoplexy. (21803712)
2011
6
Pituitary apoplexy following coronary artery bypass grafting: report of a case. (20919675)
2010
7
Pituitary apoplexy following endoscopic sinus surgery. (19930782)
2010
8
Vasospasm and cerebral infarction from pituitary apoplexy. A case report. (24148592)
2010
9
Midbrain hemorrhage mimicking pituitary apoplexy in patient using anticoagulation therapy. (21049201)
2010
10
Hypothalamic lymphoma with symptoms mimicking pituitary apoplexy. (19293554)
2009
11
Hyponatraemia after orthopaedic surgery - a case of pituitary apoplexy. (19335965)
2009
12
Pituitary apoplexy presenting as isolated third cranial nerve palsy with ptosis : two case reports. (19274125)
2009
13
Pituitary apoplexy and CABG: should we change our strategy? (17889010)
2007
14
Gonadotropin-releasing hormone agonist-induced pituitary apoplexy in treatment of prostate cancer: case report and review of literature. (17954421)
2007
15
Apoplexy of clinically silent pituitary adenoma during prostate cancer treatment with LHRH analog. (17159826)
2006
16
Pituitary apoplexy goes to the bar: litigation for delayed diagnosis, deficient vision, and death. (16845315)
2006
17
Massive stroke in a patient with pituitary apoplexy, cervical carotid artery stenosis and hypotension. (17041531)
2006
18
Pituitary apoplexy. (15617587)
2005
19
Pituitary apoplexy during therapy with cabergoline in an adolescent male with prolactin-secreting macroadenoma. (15761656)
2004
20
Management of pituitary apoplexy. (15163274)
2004
21
Intra-suprasellar meningioma mimicking pituitary apoplexy. (15118889)
2004
22
Coexistence of aneurysmal subarachnoid haemorrhage and pituitary apoplexy: Case report and review of the literature. (12852891)
2003
23
Acute sterile meningitis as a primary manifestation of pituitary apoplexy. (14669831)
2003
24
Laparoscopic anterior lumbar interbody fusion precipitating pituitary apoplexy. (11460919)
2001
25
Corticotroph cell adenoma without typical manifestations of Cushing's disease presenting with cavernous sinus syndrome following pituitary apoplexy. (11603575)
2001
26
Apoplexy of pituitary macroadenoma after combined test of anterior pituitary function. (11036877)
2000
27
Subarachnoid haemorrhage and vasospasm due to pituitary apoplexy after pituitary function tests. (10526084)
1999
28
Hemorrhagic chondroid chordoma mimicking pituitary apoplexy. (9860121)
1998
29
Pituitary apoplexy after leuprolide administration for carcinoma of the prostate. (8706284)
1996
30
Pituitary apoplexy followed by panhypopituitarism presenting as a psychiatric disorder. (8775543)
1996
31
Internal carotid artery dissection associated with pituitary apoplexy: MR findings. (7822536)
1995
32
Pituitary apoplexy following cardiopulmonary bypass: considerations for a staged cardiac and neurosurgical procedure. (8086180)
1994
33
Pituitary apoplexy and the conflicting perioperative goals of anticoagulation and hemostasis. (8452252)
1993
34
Pituitary apoplexy after coronary artery surgery. (8452282)
1993
35
Typical blood-fluid level formation on computerized tomogram in pituitary apoplexy: case report. (2334887)
1990
36
Subacute pituitary apoplexy: clinical and magnetic resonance imaging characteristics. (2385339)
1990
37
Pituitary apoplexy presenting as monocular blindness. (2610735)
1989
38
Pituitary apoplexy with intracerebral hemorrhage simulating rupture of an anterior cerebral artery aneurysm. (3353845)
1988
39
Emergency diagnosis of pituitary apoplexy. (3620035)
1987
40
Pituitary apoplexy. (3926251)
1985
41
Planum sphenoidale meningioma mimicking pituitary apoplexy: a case report. (6514160)
1984
42
Pituitary apoplexy following closed head trauma. Case report. (6886789)
1983
43
Pituitary apoplexy (spontaneous pituitary necrosis). (7301668)
1981
44
Clinical aspects of spontaneous necrosis of pituitary tumors (pituitary apoplexy). (6162928)
1981
45
Pituitary apoplexy following open-heart surgery. (6928544)
1980
46
Pituitary apoplexy. (246857)
1978
47
Simulated pituitary apoplexy: report of an unusual case due to hemorrhage into hypothalamic astrocytoma. (843014)
1977
48
Hypothalamic hypopituitarism after pituitary apoplexy in acromegaly. (197898)
1977
49
Pituitary apoplexy: a review and reappraisal. (5069376)
1972
50
Pituitary apoplexy: a case report. (5008388)
1972

Genetic Variations for Pituitary Apoplexy

Expression for genes affiliated with Pituitary Apoplexy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pituitary Apoplexy

Search GEO for disease gene expression data for Pituitary Apoplexy.

Pathways for genes affiliated with Pituitary Apoplexy

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database, 12EMD Millipore, 52QIAGEN
See all sources

Compounds for genes affiliated with Pituitary Apoplexy

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Pituitary Apoplexy according to GeneCards/GeneDecks:

(show top 50)    (show all 102)
idCompoundScoreTop Affiliating Genes
1dopamine45 29 11 2412.7GNRH1, TRH
2leuprolide acetate459.7PRL, GH1, GNRH1
3cabergoline29 45 1111.7PRL, GH1, GNRH1
4hexarelin45 2910.6GH1, PRL, POMC
517-hydroxyprogesterone45 2410.6POMC, PRL, GNRH1
6pitressin459.5POMC, NPPA
7cyproteroneacetate459.4GNRH1, PRL, INS
8naltrexone45 50 29 1112.4GNRH1, GH1, PRL, POMC
9spironolactone50 45 60 29 1113.4GNRH1, NPPA, POMC
10gnrh459.4TRH, GH1, GNRH1
11opiate459.3GNRH1, GH1, PRL, POMC
12cortisone45 2410.3GH1, POMC, INS
13ghrp459.3TRH, PRL, GH1
14pyridostigmine45 1110.2GH1, PRL, TRH
15sulpiride45 29 1111.2TRH, PRL, GH1
16clomiphene citrate459.2INS, PRL, GH1, GNRH1
17fenfluramine29 45 1111.2PRL, TRH, POMC
18desmopressin45 60 29 1112.1AVP, POMC, GH1, NPPA
19metformin45 50 1111.0INS, POMC, GH1, GNRH1
20apomorphine45 29 1111.0TRH, PRL, GH1
21dhea459.0INS, POMC, PRL, GH1
22bromocriptine29 45 1111.0GNRH1, PRL, TRH, POMC
23melatonin45 60 29 11 2412.9GH1, PRL, TRH, AVP
24ribonucleic acid458.8POMC, PRL, GH1, GNRH1
25clonidine45 29 1110.8GH1, PRL, TRH, POMC
26cocaine45 119.8POMC, TRH, PRL, GNRH1
27triiodothyronine458.8GH1, PRL, TRH, POMC
28dehydroepiandrosterone sulfate458.8GNRH1, GH1, PRL, POMC, INS
29androstenedione45 249.7GNRH1, GH1, PRL, POMC, INS
30diazepam45 50 29 1111.7NPPA, TRH, POMC
31haloperidol45 29 2 50 1112.7NPPA, PRL, TRH, POMC
32norepinephrine45 11 2410.6GNRH1, PRL, TRH, POMC, AVP
33glycerol45 11 2410.6NPPA, GH1, POMC, INS
34naloxone45 50 29 1111.6GNRH1, GH1, PRL, TRH, POMC
35metoclopramide45 119.5GNRH1, NPPA, GH1, PRL, TRH
36estradiol45 11 2410.4POMC, TRH, PRL, GH1, GNRH1
37ibmx45 29 6010.4NPPA, GH1, TRH, INS
38steroid458.3GNRH1, GH1, PRL, POMC, AVP
39hydrocortisone45 2 60 1111.2GH1, PRL, TRH, POMC, INS
40epinephrine45 11 2410.2GNRH1, NPPA, GH1, PRL, POMC, INS
41progesterone45 60 29 11 2412.2POMC, TRH, PRL, GH1, GNRH1
42creatinine458.2GNRH1, NPPA, GH1, POMC, INS, AVP
43octreotide45 60 29 1110.9GNRH1, GH1, PRL, TRH, POMC, INS
44thyroxine45 248.9GNRH1, GH1, PRL, TRH, POMC, INS
45acth457.7AVP, POMC, TRH, PRL, GH1, NPPA
46glucose457.6GH1, PRL, TRH, POMC, INS, AVP
47dexamethasone45 50 29 1110.5GNRH1, GH1, PRL, TRH, POMC, INS
48testosterone45 60 11 2410.4GNRH1, NPPA, GH1, PRL, TRH, POMC
49estrogen457.4GNRH1, NPPA, GH1, PRL, TRH, POMC
50arginine457.0GNRH1, NPPA, GH1, PRL, TRH, POMC

GO Terms for genes affiliated with Pituitary Apoplexy

Sources:
16Gene Ontology
See all sources

Cellular components related to Pituitary Apoplexy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.4INS, POMC
2secretory granuleGO:0301418.4PRL, TRH, POMC, AVP
3extracellular spaceGO:0056157.5GNRH1, NPPA, GH1, POMC, INS, AVP
4extracellular regionGO:0055766.6AVP, GNRH1, NPPA, GH1, PRL, TRH

Biological processes related to Pituitary Apoplexy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.7PRL, GH1
2ovulation cycleGO:0426989.7PRL, GNRH1
3positive regulation of JAK-STAT cascadeGO:0464279.4PRL, GH1
4female pregnancyGO:0075659.3GNRH1, NPPA, PRL
5response to ethanolGO:0454718.7GNRH1, PRL, TRH, AVP
6cell-cell signalingGO:0072678.0AVP, INS, POMC, TRH, GNRH1

Molecular functions related to Pituitary Apoplexy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1prolactin receptor bindingGO:0051489.6GH1, PRL
2receptor bindingGO:0051029.1AVP, POMC, NPPA
3neuropeptide hormone activityGO:0051849.0AVP, TRH
4hormone activityGO:0051797.8INS, POMC, PRL, GH1, NPPA, GNRH1

Products for genes affiliated with Pituitary Apoplexy

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  • Proteins
  • Lysates
  • Antibodies

Sources for Pituitary Apoplexy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet