MCID: PTT004
MIFTS: 51

Pituitary Apoplexy malady

Endocrine diseases category

Summaries for Pituitary Apoplexy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Pituitary apoplexy or pituitary tumor apoplexy is bleeding into or impaired blood supply of the... more...

MalaCards: Pituitary Apoplexy is related to acromegaly and pituitary adenoma. An important gene associated with Pituitary Apoplexy is GNRH1 (gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)), and among its related pathways are Glycoprotein hormones and Development Prolactin receptor signaling. The compounds dopamine and leuprolide acetate have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and testes, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Aliases & Classifications for Pituitary Apoplexy

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8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Characteristics (Orphanet epidemiological data):

48
pituitary apoplexy:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

pituitary apoplexy 8 10 44 48 60


External Ids:

Disease Ontology8 DOID:1129
MeSH34 D010899
NCIt39 C26853
MESH via Orphanet35 D010899
SNOMED-CT56 237701005
SNOMED-CT via Orphanet57 237701005
UMLS via Orphanet61 C0032001
ICD10 via Orphanet26 E23.0

Related Diseases for Pituitary Apoplexy

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17GeneCards, 18GeneDecks
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Diseases related to Pituitary Apoplexy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1acromegaly31.1GH1, PRL
2pituitary adenoma31.1GNRH1, PRL, TRH, POMC, GH1
3adenoma31.1POMC, GH1, INS, GNRH1, PRL, TRH
4diabetes insipidus30.7POMC, TRH, PRL, AVP
5hypopituitarism30.7GNRH1, INS, AVP, POMC, TRH, PRL
6prolactinoma30.6PRL, GNRH1, GH1, TRH, POMC
7prostate cancer30.6GNRH1
8pituitary cancer30.6PRL, POMC
9panhypopituitarism30.5GH1, AVP, PRL, POMC
10empty sella syndrome30.4GH1, PRL
11thyrotoxicosis30.4INS, TRH
12thyroiditis30.4TRH, POMC
13neuropathy30.3INS
14leukemia30.3BRD2
15cushing's syndrome30.3GH1, POMC
16amenorrhea30.3INS, POMC, GNRH1, PRL, TRH
17goiter30.1TRH
18myocardial infarction30.1NPPA
19chromophobe adenoma30.1PRL, GH1
20hyperglycemia30.1GH1, POMC, INS
21diabetes mellitus30.0NPPA, GH1, POMC, INS
22hypoglycemia30.0GNRH1, GH1, INS, PRL, TRH, AVP
23cerebritis10.6
24pituitary infarct10.6
25meningitis10.6
26prostatitis10.5
27cranial nerve palsy10.5
28carotid artery occlusion10.3
29adenocarcinoma10.3
30bacterial meningitis10.3
31functioning pituitary adenoma10.3
32meningioma10.3
33ophthalmoplegia10.3
34thrombocytopenia10.3
35dengue hemorrhagic fever10.2
36meningoencephalitis10.2
37neuritis10.2
38optic neuritis10.2
39purpura10.2
40angina pectoris10.1
41intracranial vasospasm10.1
42hellp syndrome10.1
43carotid stenosis10.1
44prostatic adenoma10.1
45status epilepticus10.1
46diabetic ketoacidosis10.1
47androgen insensitivity syndrome10.1
48central nervous system lymphoma10.1
49acute myeloid leukemia10.1
50aseptic meningitis10.1

Graphical network of the top 20 diseases related to Pituitary Apoplexy:



Diseases related to pituitary apoplexy

Clinical Features for Pituitary Apoplexy

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Drugs & Therapeutics for Pituitary Apoplexy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pituitary Apoplexy

Drug clinical trials:

Search ClinicalTrials for Pituitary Apoplexy

Search NIH Clinical Center for Pituitary Apoplexy

Search CenterWatch for Pituitary Apoplexy

Genetic Tests for Pituitary Apoplexy

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Anatomical Context for Pituitary Apoplexy

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32MalaCards
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MalaCards organs/tissues related to Pituitary Apoplexy:

32
Pituitary, Brain, Testes, Prostate, Thyroid, Liver, Myeloid, Lung, Heart, B cells, Eye

Animal Models for Pituitary Apoplexy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pituitary Apoplexy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.0BRD2
2MP:00053679.3AVP, POMC
3MP:00053759.1POMC, GH1, BRD2
4MP:00053707.7BRD2, GNRH1, GH1, PRL, POMC, INS
5MP:00036316.6BRD2, GNRH1, GH1, PRL, TRH, POMC
6MP:00053766.2AVP, BRD2, GNRH1, NPPA, GH1, PRL

Publications for Pituitary Apoplexy

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50PubMed
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Articles related to Pituitary Apoplexy:

(show top 50)    (show all 483)
idTitleAuthorsYear
1
Pituitary macroadenoma presenting with pituitary apoplexy, acromegaly and secondary diabetes mellitus - a case report. (24062868)
2013
2
Combined chronic lymphocytic leukemia and prolactinoma: a rare occurrence in a patient presenting with pituitary apoplexy. (23683075)
2013
3
Pituitary apoplexy masquerading as acute mountain sickness. (23246345)
2013
4
Giant necrotic pituitary apoplexy. (23623615)
2013
5
Pituitary metastasis presenting as ischemic pituitary apoplexy following heparin-induced thrombocytopenia. (23129546)
2012
6
Pituitary apoplexy can mimic acute meningoencephalitis or subarachnoid haemorrhage. (21975129)
2011
7
Selective pituitary tumor apoplexy apparently reversed acromegaly in Governor Pio Pico between 1858 and 1873. (20446046)
2010
8
Primary central nervous system lymphoma mimicking pituitary apoplexy: case report. (18205050)
2009
9
Pituitary apoplexy after joint arthroplasty. (18947970)
2009
10
A case of macroprolactinoma encasing an internal carotid artery aneurysm, presenting as pituitary apoplexy. (17899387)
2008
11
Pituitary apoplexy during induction chemotherapy for acute myeloid leukaemia. (18699855)
2008
12
Pituitary apoplexy as a cause of internal carotid artery occlusion. (18262423)
2008
13
Pituitary apoplexy-like disease in 4 dogs. (18196734)
2007
14
Carotid cavernous aneurysm presenting as pituitary apoplexy. (16678729)
2006
15
Pituitary tuberculosis presenting as pituitary apoplexy. (16413219)
2006
16
Surgical treatment for severe visual compromised patients after pituitary apoplexy. (16645717)
2006
17
Visual outcome of blind eyes in pituitary apoplexy after transsphenoidal surgery: a series of 14 eyes. (15639521)
2005
18
Hemorrhagic pituitary apoplexy in an 18 year-old male presenting as non-ketotic hyperglycemic coma (NKHC). (16042331)
2005
19
Pituitary apoplexy occurring during large volume liposuction surgery. (15206436)
2004
20
Pituitary apoplexy presenting as chemical meningitis. (15302191)
2004
21
Pituitary apoplexy in the setting of coronary angiography. (12889178)
2003
22
Male prolactinoma with pituitary apoplexy concomitant with intracerebral hemorrhage--case report. (11936054)
2002
23
Spontaneous haemorrhage into an empty sella turcica mimicking pituitary apoplexy. (11029243)
2000
24
Pituitary apoplexy induced by a combined anterior pituitary test: case report and literature review. (9790275)
1998
25
Pituitary apoplexy in acromegaly, a long-term follow-up study in two patients. (9648051)
1998
26
Pituitary apoplexy after leuprolide administration for carcinoma of the prostate: what's new? (9156052)
1997
27
Clomiphene-induced pituitary apoplexy in a patient with acromegaly. (8731710)
1996
28
Pituitary apoplexy after stimulation tests. (7724428)
1995
29
Atypical presentation of vascular events in pituitary tumours: "non-apoplectic" pituitary apoplexy. (7964837)
1994
30
Pituitary apoplexy and sudden blindness following the administration of gonadotrophin releasing hormone. (8435878)
1993
31
Pituitary apoplexy precipitating acute angle closure. (1463404)
1992
32
Simultaneous occurrence of transient resolving thyrotoxicosis due to painless thyroiditis, hypopituitarism and diabetes insipidus following pituitary apoplexy. (2057436)
1991
33
Bleeding intracranial aneurysm? Pituitary apoplexy! (1793704)
1991
34
Regression of pituitary macroadenoma after pituitary apoplexy: CT and MR studies. (1885805)
1991
35
Clinical versus subclinical pituitary apoplexy: presentation, surgical management, and outcome in 21 patients. (2362675)
1990
36
Stuttering pituitary apoplexy resembling meningitis. (2351979)
1990
37
Pituitary apoplexy presenting as aseptic meningitis without visual loss or ophthalmoplegia. (2222354)
1990
38
Pituitary apoplexy following coronary artery bypass surgery. (2342378)
1990
39
Empty sella syndrome and pituitary apoplexy. (2895306)
1988
40
Subclinical pituitary apoplexy. (3468387)
1986
41
Pituitary apoplexy treated by transsphenoidal surgery. A clinicopathological and immunocytochemical study. (6827315)
1983
42
Clinically asymptomatic pituitary adenoma manifesting as pituitary apoplexy and fatal third-ventricular hemorrhage. (6983489)
1982
43
Pituitary apoplexy: its incidence and clinical significance. (7252541)
1981
44
Intraventricular hemorrhage from pituitary apoplexy. (7336321)
1981
45
Pituitary apoplexy. The importance of skull roentgenograms and computerized tomography in diagnosis. (7382057)
1980
46
Pituitary apoplexy in five patients with pituitary tumours. (5572390)
1971
47
Hemorrhagic necrosis in pituitary tumors. (Pituitary apoplexy). (5232978)
1967
48
Pituitary apoplexy in a patient with acromegaly. (13735518)
1961
49
Spontaneous necrosis in pituitary tumours (pituitary apoplexy). (13632015)
1959
50
Apoplexy in a pituitary chromophobe adenoma producing the syndrome of middle cerebral artery thrombosis; case report. (14908656)
1952

Genetic Variations for Pituitary Apoplexy

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Expression for genes affiliated with Pituitary Apoplexy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pituitary Apoplexy

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Pathways for genes affiliated with Pituitary Apoplexy

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Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN
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Compounds for genes affiliated with Pituitary Apoplexy

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Pituitary Apoplexy according to GeneCards/GeneDecks:

(show top 50)    (show all 102)
idCompoundScoreTop Affiliating Genes
1dopamine44 28 11 2412.7TRH, GNRH1
2leuprolide acetate449.7GNRH1, GH1, PRL
3cabergoline28 44 1111.7GNRH1, PRL, GH1
4hexarelin44 2810.6PRL, GH1, POMC
517-hydroxyprogesterone44 2410.6POMC, PRL, GNRH1
6pitressin449.5POMC, NPPA
7cyproteroneacetate449.4PRL, GNRH1, INS
8naltrexone44 49 28 1112.4GNRH1, GH1, POMC, PRL
9spironolactone49 44 59 28 1113.4NPPA, POMC, GNRH1
10gnrh449.4GH1, TRH, GNRH1
11opiate449.3GH1, GNRH1, POMC, PRL
12cortisone44 2410.3GH1, POMC, INS
13ghrp449.3PRL, GH1, TRH
14pyridostigmine44 1110.2TRH, PRL, GH1
15sulpiride44 28 1111.2GH1, PRL, TRH
16clomiphene citrate449.2GNRH1, INS, PRL, GH1
17fenfluramine28 44 1111.2PRL, TRH, POMC
18desmopressin44 59 28 1112.1AVP, POMC, GH1, NPPA
19metformin44 49 1111.0POMC, GH1, INS, GNRH1
20apomorphine44 28 1111.0PRL, TRH, GH1
21dhea449.0INS, GH1, PRL, POMC
22bromocriptine28 44 1111.0POMC, TRH, PRL, GNRH1
23melatonin44 59 28 11 2412.9PRL, TRH, AVP, GH1
24ribonucleic acid448.8GNRH1, GH1, PRL, POMC
25clonidine44 28 1110.8POMC, PRL, GH1, TRH
26cocaine44 119.8POMC, TRH, GNRH1, PRL
27triiodothyronine448.8POMC, TRH, GH1, PRL
28dehydroepiandrosterone sulfate448.8GH1, PRL, POMC, INS, GNRH1
29androstenedione44 249.7POMC, PRL, GH1, GNRH1, INS
30diazepam44 49 28 1111.7TRH, NPPA, POMC
31haloperidol44 28 2 49 1112.7TRH, NPPA, POMC, PRL
32norepinephrine44 11 2410.6GNRH1, POMC, AVP, TRH, PRL
33glycerol44 11 2410.6POMC, GH1, NPPA, INS
34naloxone44 49 28 1111.6POMC, TRH, PRL, GH1, GNRH1
35metoclopramide44 119.5GH1, TRH, NPPA, GNRH1, PRL
36estradiol44 11 2410.4POMC, PRL, GH1, GNRH1, TRH
37ibmx44 28 5910.4INS, TRH, GH1, NPPA
38steroid448.3GH1, GNRH1, PRL, POMC, AVP
39hydrocortisone44 2 59 1111.2POMC, GH1, INS, TRH, PRL
40epinephrine44 11 2410.2INS, POMC, PRL, GH1, NPPA, GNRH1
41progesterone44 59 28 11 2412.2TRH, POMC, GNRH1, PRL, GH1
42creatinine448.2GH1, NPPA, AVP, POMC, GNRH1, INS
43octreotide44 59 28 1110.9INS, POMC, TRH, GNRH1, PRL, GH1
44thyroxine44 248.9POMC, GH1, INS, GNRH1, PRL, TRH
45acth447.7AVP, POMC, PRL, GH1, TRH, NPPA
46glucose447.6PRL, GH1, AVP, TRH, INS, POMC
47dexamethasone44 49 28 1110.5POMC, AVP, INS, TRH, PRL, GH1
48testosterone44 59 11 2410.4INS, POMC, GNRH1, NPPA, TRH, PRL
49estrogen447.4TRH, PRL, GH1, NPPA, GNRH1, POMC
50arginine447.0AVP, PRL, NPPA, GNRH1, POMC, INS

GO Terms for genes affiliated with Pituitary Apoplexy

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16Gene Ontology
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Cellular components related to Pituitary Apoplexy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.4INS, POMC
2secretory granuleGO:0301418.4PRL, TRH, POMC, AVP
3extracellular spaceGO:0056157.5GNRH1, NPPA, GH1, POMC, INS, AVP
4extracellular regionGO:0055766.6AVP, GNRH1, NPPA, GH1, PRL, TRH

Biological processes related to Pituitary Apoplexy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.7PRL, GH1
2ovulation cycleGO:0426989.7PRL, GNRH1
3positive regulation of JAK-STAT cascadeGO:0464279.4PRL, GH1
4female pregnancyGO:0075659.3GNRH1, NPPA, PRL
5response to ethanolGO:0454718.7GNRH1, PRL, TRH, AVP
6cell-cell signalingGO:0072678.0AVP, INS, POMC, TRH, GNRH1

Molecular functions related to Pituitary Apoplexy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1prolactin receptor bindingGO:0051489.6GH1, PRL
2receptor bindingGO:0051029.1AVP, POMC, NPPA
3neuropeptide hormone activityGO:0051849.0AVP, TRH
4hormone activityGO:0051797.8INS, POMC, PRL, GH1, NPPA, GNRH1

Products for genes affiliated with Pituitary Apoplexy

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Sources for Pituitary Apoplexy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet