MCID: PTT004
MIFTS: 47

Pituitary Apoplexy

Categories: Endocrine diseases, Rare diseases

Aliases & Classifications for Pituitary Apoplexy

MalaCards integrated aliases for Pituitary Apoplexy:

Name: Pituitary Apoplexy 12 55 51 41 14 69

Characteristics:

Orphanet epidemiological data:

55
pituitary apoplexy
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 55  
Rare endocrine diseases


Summaries for Pituitary Apoplexy

MalaCards based summary : Pituitary Apoplexy is related to adenoma and pituitary adenoma, and has symptoms including bitemporal hemianopia, thunderclap headache and diplopia. An important gene associated with Pituitary Apoplexy is PRL (Prolactin), and among its related pathways/superpathways are Glucocorticoid receptor regulatory network and Signaling events mediated by PTP1B. Affiliated tissues include pituitary, brain and testes, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Wikipedia : 72 Pituitary apoplexy or pituitary tumor apoplexy is bleeding into or impaired blood supply of the... more...

Related Diseases for Pituitary Apoplexy

Diseases related to Pituitary Apoplexy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 adenoma 30.0 AIP POMC PRL
2 pituitary adenoma 29.9 AIP POMC PRL
3 gigantism 29.8 AIP PRL
4 pituitary hormone deficiency, combined, 2 29.8 POMC PRL
5 pituitary adenoma, prolactin-secreting 29.6 AIP POMC PRL
6 diabetes insipidus 29.5 INS POMC PRL
7 adenohypophysitis 29.5 POMC PRL
8 acromegaly 29.4 AIP INS POMC PRL
9 functioning pituitary adenoma 29.4 AIP POMC PRL
10 diabetes insipidus, neurohypophyseal 29.2 GNRH1 POMC PRL
11 pituitary tumors 29.2 AIP POMC PRL
12 amenorrhea 29.2 GNRH1 POMC PRL
13 hypopituitarism 29.0 GNRH1 INS POMC PRL
14 empty sella syndrome 28.7 GNRH1 INS POMC PRL
15 chromophobe adenoma 28.3 GNRH1 INS POMC PRL
16 cerebritis 10.3
17 meningitis 10.3
18 aneurysm 10.3
19 prostatitis 10.2
20 stroke, ischemic 10.2
21 headache 10.2
22 endometriosis of uterus 10.2 GNRH1 PRL
23 hypogonadotropism 10.2 GNRH1 PRL
24 pituitary adenoma 1, multiple types 10.2 AIP PRL
25 cranial nerve palsy 10.2
26 multiple endocrine neoplasia, type iv 10.1 AIP PRL
27 growth hormone secreting pituitary adenoma 10.1 AIP PRL
28 lymphoma 10.1
29 granulosa cell tumor of the ovary 10.0 INS PRL
30 varicocele 10.0 GNRH1 PRL
31 prostate cancer 10.0
32 graves disease 1 10.0
33 dengue hemorrhagic fever 10.0
34 thrombocytopenia 10.0
35 ptosis 10.0
36 mucositis 10.0
37 bacterial meningitis 10.0
38 hemorrhagic fever 10.0
39 aromatase deficiency 10.0 GNRH1 INS
40 meningioma, familial 10.0
41 adenocarcinoma 10.0
42 thyroiditis 10.0
43 carotid artery occlusion 10.0
44 lymphocytic hypophysitis 10.0
45 non-functioning pituitary adenoma 10.0
46 sella turcica neoplasm 9.9 POMC PRL
47 tuberculum sellae meningioma 9.9 POMC PRL
48 nelson syndrome 9.9 POMC PRL
49 hypothyroidism, congenital, nongoitrous, 4 9.9 POMC PRL
50 acth-secreting pituitary adenoma 9.9 POMC PRL

Graphical network of the top 20 diseases related to Pituitary Apoplexy:



Diseases related to Pituitary Apoplexy

Symptoms & Phenotypes for Pituitary Apoplexy

Human phenotypes related to Pituitary Apoplexy:

55 31 (show all 42)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 bitemporal hemianopia 55 31 hallmark (90%) Very frequent (99-80%) HP:0030521
2 thunderclap headache 55 31 hallmark (90%) Very frequent (99-80%) HP:0030907
3 diplopia 55 31 frequent (33%) Frequent (79-30%) HP:0000651
4 impotence 55 31 frequent (33%) Frequent (79-30%) HP:0000802
5 hypergonadotropic hypogonadism 55 31 frequent (33%) Frequent (79-30%) HP:0000815
6 hypertension 55 31 frequent (33%) Frequent (79-30%) HP:0000822
7 oligomenorrhea 55 31 frequent (33%) Frequent (79-30%) HP:0000876
8 hypoglycemia 55 31 frequent (33%) Frequent (79-30%) HP:0001943
9 nausea and vomiting 55 31 frequent (33%) Frequent (79-30%) HP:0002017
10 hypotension 55 31 frequent (33%) Frequent (79-30%) HP:0002615
11 pituitary adenoma 55 31 frequent (33%) Frequent (79-30%) HP:0002893
12 hyponatremia 55 31 frequent (33%) Frequent (79-30%) HP:0002902
13 cranial nerve paralysis 55 31 frequent (33%) Frequent (79-30%) HP:0006824
14 prolactin deficiency 55 31 frequent (33%) Frequent (79-30%) HP:0008202
15 pituitary hypothyroidism 55 31 frequent (33%) Frequent (79-30%) HP:0008245
16 adrenocorticotropic hormone deficiency 55 31 frequent (33%) Frequent (79-30%) HP:0011748
17 abnormal kinetic perimetry test 55 31 frequent (33%) Frequent (79-30%) HP:0030591
18 abnormal static automated perimetry test 55 31 frequent (33%) Frequent (79-30%) HP:0030595
19 ptosis 55 31 occasional (7.5%) Occasional (29-5%) HP:0000508
20 photophobia 55 31 occasional (7.5%) Occasional (29-5%) HP:0000613
21 blurred vision 55 31 occasional (7.5%) Occasional (29-5%) HP:0000622
22 growth hormone deficiency 55 31 occasional (7.5%) Occasional (29-5%) HP:0000824
23 prolactin excess 55 31 occasional (7.5%) Occasional (29-5%) HP:0000870
24 pallor 55 31 occasional (7.5%) Occasional (29-5%) HP:0000980
25 coma 55 31 occasional (7.5%) Occasional (29-5%) HP:0001259
26 fever 55 31 occasional (7.5%) Occasional (29-5%) HP:0001945
27 abnormality of the cerebrospinal fluid 55 31 occasional (7.5%) Occasional (29-5%) HP:0002921
28 reduced visual acuity 55 31 occasional (7.5%) Occasional (29-5%) HP:0007663
29 mydriasis 55 31 occasional (7.5%) Occasional (29-5%) HP:0011499
30 fatigue 55 31 occasional (7.5%) Occasional (29-5%) HP:0012378
31 galactorrhea 55 31 occasional (7.5%) Occasional (29-5%) HP:0100829
32 growth hormone excess 55 31 very rare (1%) Very rare (<4-1%) HP:0000845
33 central diabetes insipidus 55 31 very rare (1%) Very rare (<4-1%) HP:0000863
34 excessive daytime somnolence 55 31 very rare (1%) Very rare (<4-1%) HP:0001262
35 confusion 55 31 very rare (1%) Very rare (<4-1%) HP:0001289
36 normochromic anemia 55 31 very rare (1%) Very rare (<4-1%) HP:0001895
37 abnormality of the caudate nucleus 55 31 very rare (1%) Very rare (<4-1%) HP:0002339
38 trigeminal neuralgia 55 31 very rare (1%) Very rare (<4-1%) HP:0100661
39 headache 55 Frequent (79-30%)
40 hypopituitarism 55 Occasional (29-5%)
41 hypercortisolism 55 Very rare (<4-1%)
42 increased circulating cortisol level 31 very rare (1%) HP:0003118

MGI Mouse Phenotypes related to Pituitary Apoplexy:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.72 POMC PRL AIP GNRH1 INS
2 homeostasis/metabolism MP:0005376 9.65 INS POMC PRL AIP GNRH1
3 integument MP:0010771 9.55 POMC PRL AIP GNRH1 INS
4 liver/biliary system MP:0005370 9.35 POMC PRL AIP GNRH1 INS
5 neoplasm MP:0002006 8.92 POMC PRL AIP GNRH1

Drugs & Therapeutics for Pituitary Apoplexy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prevalence of a High-intensity Signal of the Oculomotor Nerve on T2 MRI Sequence in Patients With Ophthalmoplegia Recruiting NCT03135574
2 Prevalence of Contrast Enhancement of the Oculomotor Nerve on 3D PD T1 MRI Sequence in Patients With Ophthalmoplegia Recruiting NCT03269682

Search NIH Clinical Center for Pituitary Apoplexy

Cochrane evidence based reviews: pituitary apoplexy

Genetic Tests for Pituitary Apoplexy

Anatomical Context for Pituitary Apoplexy

MalaCards organs/tissues related to Pituitary Apoplexy:

38
Pituitary, Brain, Testes, Prostate, Caudate Nucleus, Thyroid, Lung

Publications for Pituitary Apoplexy

Articles related to Pituitary Apoplexy:

(show top 50) (show all 567)
# Title Authors Year
1
Corrigendum to "In Reply to the Letter to the Editor Regarding "Endoscopic Endonasal Surgery for Pituitary Apoplexy: Evidence On a 75 Case-Series From a Tertiary Care Center" [World Neurosurgery 109 (2018) 502]. ( 29398620 )
2018
2
In Reply to the Letter to the Editor Regarding "Endoscopic Endonasal Surgery for Pituitary Apoplexy: Evidence On a 75 Case-Series From a Tertiary Care Center". ( 29232810 )
2018
3
Letter to the Editor Regarding "Endoscopic Endonasal Surgery for Pituitary Apoplexy: Evidence On a 75 Case-Series From a Tertiary Care Center". ( 29232809 )
2018
4
A rare case of spontaneous Cushing disease remission induced by pituitary apoplexy. ( 28251551 )
2017
5
Sphenoid sinus microbiota in pituitary apoplexy: a preliminary study. ( 28853001 )
2017
6
Pituitary apoplexy: a rare complication of leuprolide therapy in prostate cancer treatment. ( 28710301 )
2017
7
Endoscopic Endonasal Surgery for Treatment of Pituitary Apoplexy: 16 Years of Experience in a Specialized Pituitary Center: Endoscopic Surgery for Pituitary Apoplexy. ( 28867316 )
2017
8
Management dilemmas in a rare case of pituitary apoplexy in the setting of dengue hemorrhagic fever. ( 28217383 )
2017
9
Indomethacin-Responsive Paroxysmal Hemicrania in an Elderly Man: An Unusual Presentation of Pituitary Apoplexy. ( 28980712 )
2017
10
The impact of surgical timing on visual outcome in pituitary apoplexy: Literature review and case illustration. ( 28217395 )
2017
11
Pituitary apoplexy - A single center retrospective study from the neurosurgical perspective and review of the literature. ( 29055223 )
2017
12
Intrasellar dermoid cyst mimicking pituitary apoplexy: A case report and review of the literature. ( 28601571 )
2017
13
Hypersomatotropism induced secondary polycythaemia leading to spontaneous pituitary apoplexy resulting in cure of acromegaly and remission of polycythaemia: 'The virtuous circle'. ( 29222208 )
2017
14
Pituitary Ring Sign Plus Sphenoid Sinus Mucosal Thickening: Neuroimaging Signs of Pituitary Apoplexy. ( 29344069 )
2017
15
Gestational Pituitary Apoplexy. ( 28553611 )
2017
16
Repeated Headache as Presentation of Pituitary Apoplexy in the Adolescent Population: Unusual Entity with Review of Literature. ( 28936095 )
2017
17
Endoscopic Endonasal Surgery for Pituitary Apoplexy: Evidence On a 75-Case Series From a Tertiary Care Center. ( 28669873 )
2017
18
Pituitary apoplexy presenting as a peripheral rim enhancing parasellar mass lesion with dural enhancement along the tentorium. ( 28581357 )
2017
19
Pituitary Apoplexy: Should Endoscopic Surgery Be the Gold Standard? ( 29288106 )
2017
20
Delayed Onset of Isolated Unilateral Oculomotor Nerve Palsy Caused by Post-Traumatic Pituitary Apoplexy: A Case Report. ( 28979174 )
2017
21
Pituitary Apoplexy Presenting as Status Migrainosus. ( 28181226 )
2017
22
Surgical intervention for pituitary apoplexy: an analysis of functional outcomes. ( 28946177 )
2017
23
Pituitary Apoplexy Mimicking Bacterial Meningitis with Intracranial Hypertension. ( 27756666 )
2017
24
Presenting Symptoms of Pituitary Apoplexy. ( 28437813 )
2017
25
New Oral Anticoagulants and Pituitary Apoplexy. ( 28437880 )
2017
26
Postoperative Neurologic Outcome in Patients with Pituitary Apoplexy After Transsphenoidal Surgery. ( 29191540 )
2017
27
Sphenoid sinus mucosal thickening in the acute phase of pituitary apoplexy. ( 28421421 )
2017
28
Pituitary apoplexy and rivaroxaban. ( 28831662 )
2017
29
Acute Ischaemic Stroke as a Manifestation of Pituitary Apoplexy in a Young Lady. ( 28658829 )
2017
30
Pituitary apoplexy as presentation of atypical teratoid/rhabdoid tumor in an adult. ( 27349334 )
2016
31
Pituitary apoplexy presenting as diabetic ketoacidosis: A great simulator? Case Report. ( 26994379 )
2016
32
SOCIETY FOR ENDOCRINOLOGY ENDOCRINE EMERGENCY GUIDANCE: Emergency management of pituitary apoplexy in adult patients. ( 27935817 )
2016
33
Pituitary Apoplexy- Bespoke Patient Management Allows Good Clinical Outcome. ( 27038242 )
2016
34
Management of pituitary apoplexy. ( 27006559 )
2016
35
Pituitary apoplexy causing clival and spinal haematoma. ( 26743947 )
2016
36
Pituitary Apoplexy After Initial Leuprolide Injection. ( 27586180 )
2016
37
A primer on pituitary injury for the obstetrician gynecologist: Simmonds disease, Sheehan's syndrome, Traumatic injury, Dahan' s syndrome, Pituitary Apoplexy and Lymphocytic Hypophysitis. ( 27405776 )
2016
38
Pituitary Apoplexy Associated with Carotid Compression and a Large Ischemic Penumbra. ( 27319311 )
2016
39
Pituitary tuberculoma: A consideration in the differential diagnosis in a patient manifesting with pituitary apoplexy-like syndrome. ( 27516966 )
2016
40
Pituitary apoplexy causing spontaneous remission of acromegaly following long-acting octreotide therapy: a rare drug side effect or just a coincidence. ( 27123308 )
2016
41
Pituitary apoplexy masquerading as functional decline in an older person. ( 27810852 )
2016
42
Poster 329 Rehabilitation of Horizontal Diplopia due to Abducens Nerve Palsy in an Idiopathic Pituitary Apoplexy: A Case Report. ( 27673084 )
2016
43
Surgical versus non-surgical treatment for pituitary apoplexy: A systematic review and meta-analysis. ( 27772771 )
2016
44
A pediatric case of pituitary macroadenoma presenting with pituitary apoplexy and cranial nerve involvement: case report. ( 27738402 )
2016
45
PITUITARY APOPLEXY DUE TO DAIGNOSTIC TEST IN CUSHING'S DISEASE PATIENT. ( 27593808 )
2016
46
Spontaneous pituitary apoplexy during the second trimester of pregnancy, with sensory loss. ( 26884071 )
2016
47
Pituitary apoplexy: considerations on a single center experience and review of the literature. ( 26733212 )
2016
48
Primary immune thrombocytopenia accompanied by pituitary apoplexy. ( 27498733 )
2016
49
Gonadotropin-releasing hormone agonist-induced pituitary apoplexy. ( 27284452 )
2016
50
A case of pituitary apoplexy masquerading as subarachnoid hemorrhage. ( 27014446 )
2016

Variations for Pituitary Apoplexy

Expression for Pituitary Apoplexy

Search GEO for disease gene expression data for Pituitary Apoplexy.

Pathways for Pituitary Apoplexy

Pathways related to Pituitary Apoplexy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.87 POMC PRL
2 10.32 INS PRL

GO Terms for Pituitary Apoplexy

Cellular components related to Pituitary Apoplexy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule lumen GO:0034774 8.96 INS POMC
2 endosome lumen GO:0031904 8.62 INS PRL

Biological processes related to Pituitary Apoplexy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glucose homeostasis GO:0042593 9.26 INS POMC
2 female pregnancy GO:0007565 9.16 GNRH1 PRL
3 cell-cell signaling GO:0007267 9.13 GNRH1 INS POMC
4 regulation of receptor activity GO:0010469 8.92 GNRH1 INS POMC PRL

Molecular functions related to Pituitary Apoplexy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.92 GNRH1 INS POMC PRL

Sources for Pituitary Apoplexy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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