MCID: PTT004
MIFTS: 54

Pituitary Apoplexy malady

Endocrine diseases, Rare diseases categories
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Summaries for Pituitary Apoplexy

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65Wikipedia, 33MalaCards
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Wikipedia:65 Pituitary apoplexy or pituitary tumor apoplexy is bleeding into or impaired blood supply of the... more...

MalaCards: Pituitary Apoplexy is related to acromegaly and adenoma. An important gene associated with Pituitary Apoplexy is GNRH1 (gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)), and among its related pathways are Nuclear signaling by ERBB4 and Growth hormone receptor signaling. The compounds leuprolide acetate and cabergoline have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and testes, and related mouse phenotypes are tumorigenesis and renal/urinary system.

Aliases & Classifications for Pituitary Apoplexy

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8Disease Ontology, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH, 36MESH via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Endocrine diseases


Characteristics (Orphanet epidemiological data):

49
pituitary apoplexy:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

pituitary apoplexy 8 10 45 49 62


External Ids:

Disease Ontology8 DOID:1129
NCIt40 C26853
MeSH35 D010899
MESH via Orphanet36 D010899
SNOMED-CT58 237701005
SNOMED-CT via Orphanet59 237701005
UMLS via Orphanet63 C0032001
ICD10 via Orphanet26 E23.0

Related Diseases for Pituitary Apoplexy

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17GeneCards, 18GeneDecks
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Diseases related to Pituitary Apoplexy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1acromegaly31.3GH1, PRL
2adenoma30.9GNRH1, TRH, POMC, PRL, INS, GH1
3pituitary adenoma30.9TRH, AIP, GNRH1, POMC, PRL, GH1
4diabetes insipidus30.8AVP, PRL, POMC, TRH
5empty sella syndrome30.6GH1, PRL
6panhypopituitarism30.6GH1, AVP, POMC, PRL
7prolactinoma30.6POMC, PRL, GH1, TRH, GNRH1, AIP
8thyroiditis30.6POMC, TRH
9hypopituitarism30.6TRH, POMC, GNRH1, INS, AVP, PRL
10thyrotoxicosis30.5INS, TRH
11chromophobe adenoma30.3PRL, GH1
12amenorrhea30.2INS, GNRH1, POMC, PRL, TRH
13cushing's syndrome30.2GH1, POMC
14pituitary tumors30.2POMC, TRH, PRL, GNRH1, AIP, GH1
15gigantism30.2AIP, GH1, PRL
16hyperglycemia30.1INS, POMC, GH1
17growth hormone deficiency30.1POMC, PRL, INS, GH1
18diabetes mellitus30.0GH1, INS, POMC, NPPA
19hypoglycemia29.9AVP, INS, GNRH1, POMC, PRL, GH1
20cerebritis10.6
21meningitis10.6
22aneurysm10.6
23blindness10.6
24prostatitis10.6
25cranial nerve palsy10.5
26prostate cancer10.5
27headache10.5
28carotid artery occlusion10.3
29adenocarcinoma10.3
30bacterial meningitis10.3
31functioning pituitary adenoma10.3
32meningioma10.3
33ophthalmoplegia10.3
34thrombocytopenia10.3
35non-functioning pituitary adenoma10.3
36meningoencephalitis10.3
37dengue hemorrhagic fever10.3
38leukemia10.3
39neuritis10.3
40neuropathy10.3
41optic neuritis10.3
42purpura10.3
43hemorrhagic fever10.3
44lymphocytic hypophysitis10.3
45thunderclap headache10.3
46head injury10.3
47exophthalmos10.1TRH
48hyperthyroxinemia10.1TRH
49euthyroid sick syndrome10.1TRH
50turner syndrome10.1GNRH1

Graphical network of the top 20 diseases related to Pituitary Apoplexy:



Diseases related to pituitary apoplexy

Symptoms for Pituitary Apoplexy

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Drugs & Therapeutics for Pituitary Apoplexy

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Pituitary Apoplexy

Search NIH Clinical Center for Pituitary Apoplexy

Genetic Tests for Pituitary Apoplexy

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Anatomical Context for Pituitary Apoplexy

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33MalaCards
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MalaCards organs/tissues related to Pituitary Apoplexy:

33
Pituitary, Brain, Testes, Prostate, Thyroid, Myeloid, Liver, Eye, B cells, Lung, Heart

Animal Models for Pituitary Apoplexy or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Pituitary Apoplexy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5PRL, POMC, GNRH1, AIP
2MP:00053678.2AVP, INS, GNRH1, POMC, NPPA
3MP:00107717.8AIP, INS, GNRH1, POMC, PRL
4MP:00053707.6AIP, INS, GNRH1, POMC, PRL, GH1
5MP:00036317.5AVP, INS, GNRH1, POMC, PRL, GH1
6MP:00053797.1AIP, INS, GNRH1, POMC, PRL, GH1
7MP:00053787.0AIP, INS, GNRH1, POMC, GH1, TRH
8MP:00053766.3TRH, AVP, AIP, INS, GNRH1, POMC

Publications for Pituitary Apoplexy

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52PubMed
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Articles related to Pituitary Apoplexy:

(show top 50)    (show all 460)
idTitleAuthorsYear
1
Presentation, management and outcomes in acute pituitary apoplexy: a large single-centre experience from the United Kingdom. (23909507)
2013
2
A case of acromegaly complicated with diabetic ketoacidosis, pituitary apoplexy, and lymphoma. (24296058)
2013
3
Pituitary apoplexy. A case report. (22520169)
2013
4
Pituitary apoplexy associated with cabergoline therapy. (24113159)
2013
5
Pituitary apoplexy caused by hemorrhage from pituitary metastatic melanoma: case report. (24077271)
2013
6
Sellar and parasellar intravascular lymphoma mimicking pituitary apoplexy. (22173269)
2012
7
An unusual case of sudden onset headache due to pituitary apoplexy: a case report and review of the new UK guidelines. (22693695)
2012
8
Pituitary apoplexy presenting atypical time course of ophthalmic symptoms. (22576705)
2012
9
Pituitary metastasis presenting as ischemic pituitary apoplexy following heparin-induced thrombocytopenia. (23129546)
2012
10
Pituitary apoplexy. (21415110)
2011
11
Pituitary apoplexy can mimic acute meningoencephalitis or subarachnoid haemorrhage. (21975129)
2011
12
Manifestation of a sellar hemangioblastoma due to pituitary apoplexy: a case report. (21970745)
2011
13
Pituitary apoplexy. (22029023)
2011
14
Pituitary apoplexy following coronary artery bypass grafting: report of a case. (20919675)
2010
15
Development of pituitary apoplexy during TRH/GnRH test in a patient with pituitary macroadenoma. (21140103)
2010
16
Isolated unilateral abducens cranial nerve palsy: a rare presentation of pituitary apoplexy. (19882540)
2010
17
Pituitary abscess with panhypopituitarism showing T1 signal hyperintensity of the marginal pituitary area: a non-invasive differential diagnosis of pituitary abscess and pituitary apoplexy. (19293544)
2009
18
Hypothalamic lymphoma with symptoms mimicking pituitary apoplexy. (19293554)
2009
19
Primary central nervous system lymphoma mimicking pituitary apoplexy: case report. (18205050)
2009
20
Extensive spherical amyloid deposition of pituitary adenoma presenting as pituitary apoplexy. (18280642)
2008
21
A case of macroprolactinoma encasing an internal carotid artery aneurysm, presenting as pituitary apoplexy. (17899387)
2008
22
Blindness following pituitary apoplexy: timing of surgery and neuro-ophthalmic outcome. (18502643)
2008
23
Transient central diabetes insipidus followed by pituitary apoplexy treated in a conservative way. (18641885)
2008
24
Pituitary apoplexy and CABG: should we change our strategy? (17889010)
2007
25
Optic tract hemorrhage after pituitary apoplexy. (17213443)
2007
26
Perirolandic sparing and pituitary apoplexy in adult brain with global hypoxia. A case report. (24299937)
2007
27
Pituitary apoplexy after aortic abdominal aneurysm surgery: a case report. (16612920)
2006
28
Pituitary apoplexy after leuprolide. (16832587)
2006
29
Pituitary apoplexy and idiopathic thrombocytopenic purpura: a new case and review of the literature. (16328568)
2004
30
Cerebral infarction following pituitary apoplexy--case report. (15600283)
2004
31
Pituitary apoplexy presenting as unilateral third cranial nerve palsy after coronary artery bypass surgery. (14693581)
2004
32
Coexistence of aneurysmal subarachnoid haemorrhage and pituitary apoplexy: Case report and review of the literature. (12852891)
2003
33
Suspected pituitary apoplexy in a German shorthaired pointer. (14635962)
2003
34
Pituitary apoplexy presenting as postoperative stupor. (11839866)
2002
35
Perioperative management of a patient requiring surgery for pituitary apoplexy and severe angina pectoris. (11094603)
2000
36
Spontaneous haemorrhage into an empty sella turcica mimicking pituitary apoplexy. (11029243)
2000
37
Subacute pituitary apoplexy-analysis of 17 cases. (10089716)
1999
38
Acute painful oculomotor nerve paresis caused by pituitary apoplexy--a case report. (10465926)
1999
39
Pituitary apoplexy after spinal anaesthesia. (9924246)
1998
40
Pituitary apoplexy after leuprolide administration for carcinoma of the prostate. (8706284)
1996
41
A retrospective analysis of pituitary apoplexy. (8232799)
1993
42
Pituitary apoplexy and the conflicting perioperative goals of anticoagulation and hemostasis. (8452252)
1993
43
Pituitary apoplexy: endocrine, surgical and oncological emergency. Incidence, clinical course and treatment with reference to 799 cases of pituitary adenomas. (8460561)
1993
44
Pituitary apoplexy in a patient with prolactinoma following computerized tomography scan. (1341487)
1992
45
Visual recovery after blindness from pituitary apoplexy. (2178757)
1990
46
Pituitary apoplexy after combined test of anterior pituitary function. (3926050)
1985
47
Pituitary apoplexy. (3926251)
1985
48
Pituitary apoplexy: a review. (6369168)
1984
49
Pituitary apoplexy. The importance of skull roentgenograms and computerized tomography in diagnosis. (7382057)
1980
50
A case of acromegaly improved by pituitary apoplexy. (168061)
1975

Variations for Pituitary Apoplexy

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Expression for genes affiliated with Pituitary Apoplexy

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pituitary Apoplexy

Search GEO for disease gene expression data for Pituitary Apoplexy.

Pathways for genes affiliated with Pituitary Apoplexy

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Sources:
50PathCards, 55Reactome, 38NCBI BioSystems Database, 60Thomson Reuters, 12EMD Millipore, 53QIAGEN, 30KEGG
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Pathways related to Pituitary Apoplexy according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7PRL, GH1
29.7PRL, GH1
39.5PRL, INS
4
Show member pathways
9.5TRH, POMC
59.5INS, AVP
6
Show member pathways
9.3TRH, GNRH1, AVP
7
Show member pathways
9.1INS, GNRH1, GH1
8
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
9.1GH1, PRL, INS
99.1GH1, PRL, INS
10
Show member pathways
9.0INS, POMC, GH1
11
Show member pathways
8.8INS, GNRH1, PRL, GH1
12
Show member pathways
8.0TRH, GH1, PRL, POMC, GNRH1, AVP
13
Show member pathways
7.4AVP, INS, GNRH1, POMC, PRL, GH1

Compounds for genes affiliated with Pituitary Apoplexy

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45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 61Tocris Bioscience, 51PharmGKB, 3BitterDB
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Compounds related to Pituitary Apoplexy according to GeneCards/GeneDecks:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
1leuprolide acetate459.7GNRH1, PRL, GH1
2cabergoline45 29 1111.6GNRH1, PRL, GH1
3hexarelin45 2910.6POMC, PRL, GH1
417-hydroxyprogesterone45 2410.6PRL, POMC, GNRH1
5ghrp459.6GH1, PRL, TRH
6pyridostigmine45 1110.5PRL, TRH, GH1
7sulpiride45 29 1111.5GH1, TRH, PRL
8fenfluramine45 29 1111.5TRH, PRL, POMC
9cyproteroneacetate459.4INS, GNRH1, PRL
10spironolactone45 61 29 51 1113.4POMC, GNRH1, NPPA
11naltrexone45 29 51 1112.4GH1, GNRH1, POMC, PRL
12opiate459.3GH1, PRL, POMC, GNRH1
13apomorphine29 45 1111.3TRH, GH1, PRL
14cortisone45 2410.2INS, POMC, GH1
15clomiphene citrate459.2GH1, GNRH1, INS, PRL
16melatonin45 29 61 24 1113.2PRL, AVP, GH1, TRH
17clonidine45 51 29 1112.1POMC, TRH, PRL, GH1
18cocaine45 1110.1PRL, TRH, GNRH1, POMC
19desmopressin45 61 29 1112.1AVP, POMC, GH1, NPPA
20triiodothyronine459.1GH1, POMC, PRL, TRH
21metformin45 51 1111.0POMC, GNRH1, INS, GH1
22dhea459.0INS, POMC, PRL, GH1
23haloperidol45 51 29 3 1113.0PRL, NPPA, TRH, POMC
24bromocriptine45 29 1110.9PRL, POMC, GNRH1, GH1, TRH
25naloxone45 29 51 1111.9GNRH1, TRH, GH1, PRL, POMC
26ribonucleic acid458.8GNRH1, PRL, GH1, POMC
27metoclopramide45 51 1110.8TRH, GNRH1, PRL, GH1, NPPA
28dehydroepiandrosterone sulfate458.8POMC, GNRH1, INS, GH1, PRL
29androstenedione45 249.7GH1, INS, GNRH1, PRL, POMC
30estradiol45 24 1110.7POMC, GH1, TRH, GNRH1, PRL
31diazepam45 29 51 1111.7POMC, TRH, NPPA
32ibmx45 61 2910.7TRH, NPPA, GH1, INS
33glycerol45 24 1110.6GH1, NPPA, POMC, INS
34steroid458.6GH1, PRL, POMC, AVP, GNRH1
35progesterone45 29 61 24 1112.5POMC, GNRH1, GH1, PRL, TRH
36hydrocortisone45 3 61 1111.5PRL, TRH, POMC, INS, GH1
37dopamine45 29 24 1111.3GNRH1, GH1, TRH, POMC, PRL, NPPA
38alanine458.3GH1, POMC, AVP, GNRH1, INS
39octreotide45 61 29 1111.2GH1, POMC, PRL, GNRH1, INS, TRH
40thyroxine45 249.2POMC, INS, PRL, GH1, TRH, GNRH1
41gnrh458.2GH1, INS, GNRH1, POMC, TRH, PRL
42epinephrine45 24 1110.2GH1, NPPA, PRL, INS, POMC, GNRH1
43creatinine458.2GH1, NPPA, AVP, POMC, GNRH1, INS
44glucose458.0AVP, INS, POMC, PRL, GH1, TRH
45dexamethasone45 51 29 1110.8AVP, TRH, GH1, INS, POMC, PRL
46testosterone45 61 24 1110.7TRH, INS, PRL, NPPA, GNRH1, POMC
47estrogen457.7TRH, POMC, PRL, GH1, GNRH1, INS
48norepinephrine45 24 119.4PRL, GH1, TRH, NPPA, POMC, GNRH1
49acth457.4TRH, NPPA, PRL, POMC, GNRH1, GH1
50arginine457.3AVP, TRH, NPPA, POMC, GNRH1, INS

GO Terms for genes affiliated with Pituitary Apoplexy

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16Gene Ontology
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Cellular components related to Pituitary Apoplexy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.4POMC, INS
2secretory granuleGO:0301418.8TRH, POMC, AVP
3extracellular spaceGO:0056157.7AVP, INS, GNRH1, POMC, GH1, NPPA
4extracellular regionGO:0055766.9TRH, AVP, INS, GNRH1, POMC, PRL

Biological processes related to Pituitary Apoplexy according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of JAK-STAT cascadeGO:0464279.9GH1, PRL
2JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.9GH1, PRL
3generation of precursor metabolites and energyGO:0060919.7AVP, POMC
4positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.6GH1, INS
5female pregnancyGO:0075659.5GNRH1, PRL, NPPA
6negative regulation of feeding behaviorGO:20002529.5INS, TRH
7regulation of blood pressureGO:0082179.5NPPA, POMC
8response to ethanolGO:0454719.5TRH, GNRH1, AVP
9positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.4GH1, INS
10glucose transportGO:0157589.3GH1, INS
11positive regulation of cell growthGO:0303079.2INS, AVP
12cell-cell signalingGO:0072678.4TRH, POMC, GNRH1, INS, AVP
13signal transductionGO:0071658.2AVP, AIP, GNRH1, POMC, TRH

Molecular functions related to Pituitary Apoplexy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1prolactin receptor bindingGO:0051489.6PRL, GH1
2neuropeptide hormone activityGO:0051849.3TRH, AVP
3receptor bindingGO:0051029.1NPPA, POMC, AVP
4hormone activityGO:0051797.8NPPA, GH1, PRL, POMC, GNRH1, INS

Products for genes affiliated with Pituitary Apoplexy

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Sources for Pituitary Apoplexy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet