MCID: PTT004
MIFTS: 51

Pituitary Apoplexy malady

Endocrine diseases category

Summaries for Pituitary Apoplexy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Pituitary apoplexy or pituitary tumor apoplexy is bleeding into or impaired blood supply of the... more...

MalaCards: Pituitary Apoplexy is related to acromegaly and pituitary adenoma. An important gene associated with Pituitary Apoplexy is GNRH1 (gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)), and among its related pathways are Glycoprotein hormones and Development Prolactin receptor signaling. The compounds dopamine and leuprolide acetate have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and testes, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Aliases & Classifications for Pituitary Apoplexy

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8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Characteristics (Orphanet epidemiological data):

48
pituitary apoplexy:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

pituitary apoplexy 8 10 44 48 60


External Ids:

Disease Ontology8 DOID:1129
MeSH34 D010899
NCIt39 C26853
MESH via Orphanet35 D010899
SNOMED-CT56 237701005
SNOMED-CT via Orphanet57 237701005
UMLS via Orphanet61 C0032001
ICD10 via Orphanet26 E23.0

Related Diseases for Pituitary Apoplexy

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17GeneCards, 18GeneDecks
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Diseases related to Pituitary Apoplexy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1acromegaly31.1GH1, PRL
2pituitary adenoma31.1GNRH1, PRL, TRH, POMC, GH1
3adenoma31.1POMC, GH1, INS, GNRH1, PRL, TRH
4diabetes insipidus30.7POMC, TRH, PRL, AVP
5hypopituitarism30.7GNRH1, INS, AVP, POMC, TRH, PRL
6prolactinoma30.6PRL, GNRH1, GH1, TRH, POMC
7prostate cancer30.6GNRH1
8pituitary cancer30.6PRL, POMC
9panhypopituitarism30.5GH1, AVP, PRL, POMC
10empty sella syndrome30.4GH1, PRL
11thyrotoxicosis30.4INS, TRH
12thyroiditis30.4TRH, POMC
13neuropathy30.3INS
14leukemia30.3BRD2
15cushing's syndrome30.3GH1, POMC
16amenorrhea30.3INS, POMC, GNRH1, PRL, TRH
17goiter30.1TRH
18myocardial infarction30.1NPPA
19chromophobe adenoma30.1PRL, GH1
20hyperglycemia30.1GH1, POMC, INS
21diabetes mellitus30.0NPPA, GH1, POMC, INS
22hypoglycemia30.0GNRH1, GH1, INS, PRL, TRH, AVP
23cerebritis10.6
24pituitary infarct10.6
25meningitis10.6
26prostatitis10.5
27cranial nerve palsy10.5
28carotid artery occlusion10.3
29adenocarcinoma10.3
30bacterial meningitis10.3
31functioning pituitary adenoma10.3
32meningioma10.3
33ophthalmoplegia10.3
34thrombocytopenia10.3
35dengue hemorrhagic fever10.2
36meningoencephalitis10.2
37neuritis10.2
38optic neuritis10.2
39purpura10.2
40angina pectoris10.1
41intracranial vasospasm10.1
42hellp syndrome10.1
43carotid stenosis10.1
44prostatic adenoma10.1
45status epilepticus10.1
46diabetic ketoacidosis10.1
47androgen insensitivity syndrome10.1
48central nervous system lymphoma10.1
49acute myeloid leukemia10.1
50aseptic meningitis10.1

Graphical network of the top 20 diseases related to Pituitary Apoplexy:



Diseases related to pituitary apoplexy

Clinical Features for Pituitary Apoplexy

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Drugs & Therapeutics for Pituitary Apoplexy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pituitary Apoplexy

Drug clinical trials:

Search ClinicalTrials for Pituitary Apoplexy

Search NIH Clinical Center for Pituitary Apoplexy

Search CenterWatch for Pituitary Apoplexy

Genetic Tests for Pituitary Apoplexy

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Anatomical Context for Pituitary Apoplexy

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32MalaCards
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MalaCards organs/tissues related to Pituitary Apoplexy:

32
Pituitary, Brain, Testes, Prostate, Thyroid, Liver, Myeloid, Lung, Heart, B cells, Eye

Animal Models for Pituitary Apoplexy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pituitary Apoplexy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.0BRD2
2MP:00053679.3AVP, POMC
3MP:00053759.1POMC, GH1, BRD2
4MP:00053707.7BRD2, GNRH1, GH1, PRL, POMC, INS
5MP:00036316.6BRD2, GNRH1, GH1, PRL, TRH, POMC
6MP:00053766.2AVP, BRD2, GNRH1, NPPA, GH1, PRL

Publications for Pituitary Apoplexy

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50PubMed
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Articles related to Pituitary Apoplexy:

(show top 50)    (show all 483)
idTitleAuthorsYear
1
Stroke associated with pituitary apoplexy in a giant prolactinoma: A case report. (24309150)
2014
2
Pituitary apoplexy associated with cabergoline therapy. (24113159)
2013
3
An unusual case of pituitary apoplexy. (23625527)
2013
4
Spontaneous regression of non-functioning pituitary adenoma due to pituitary apoplexy following anticoagulation treatment - a case report and review of the literature. (23450448)
2013
5
Retroclival subdural haematoma secondary to pituitary apoplexy. (23730978)
2013
6
An unusual case of sudden onset headache due to pituitary apoplexy: a case report and review of the new UK guidelines. (22693695)
2012
7
Imaging diagnosis: pituitary apoplexy in a cat. (22548279)
2012
8
Delayed postoperative pituitary apoplexy after endoscopic transsphenoidal resection of a giant pituitary macroadenoma. (22721888)
2012
9
High altitude-induced pituitary apoplexy. (22711047)
2012
10
The temporal association of sphenoid sinus mucosal thickening on MR imaging with pituitary apoplexy. (23208917)
2012
11
Pituitary apoplexy associated with endocrine stimulation test: endocrine stimulation test, treatment, and outcome. (22934202)
2012
12
Endoscopic surgical treatment for pituitary apoplexy in three elderly patients over the age of 80. (21725796)
2011
13
Pituitary apoplexy in non-functioning pituitary adenomas: long term follow up is important because of significant numbers of tumour recurrences. (21521336)
2011
14
A case of pituitary apoplexy masquerading as hyperemesis gravidarum. (21973146)
2011
15
Pituitary apoplexy: evaluation, management, and prognosis. (19809320)
2009
16
Manifestation, management and outcome of subclinical pituitary adenoma apoplexy. (19577475)
2009
17
Bilateral internal carotid artery aneurysm simulating pituitary apoplexy: case report. (19934939)
2009
18
Pituitary Apoplexy due to Pituitary Adenoma Infarction. (19096606)
2008
19
Optic tract hemorrhage after pituitary apoplexy. (17213443)
2007
20
Pituitary apoplexy. (16174890)
2005
21
Pituitary apoplexy and idiopathic thrombocytopenic purpura: a new case and review of the literature. (16328568)
2004
22
Pituitary apoplexy: a pathologic entity from an otolaryngologist's view. (12824735)
2003
23
Full-blown Cushing's disease after an episode of pituitary apoplexy. (14614205)
2003
24
Pituitary apoplexy caused by ruptured internal carotid artery aneurysm. (11157198)
2001
25
Pituitary apoplexy caused by luteinizing hormone-releasing hormone in prolactin-producing adenoma. (11518116)
2001
26
Intrasellar tuberculoma presenting as pituitary apoplexy. (11799419)
2001
27
Pituitary apoplexy with optic tract oedema and haemorrhage in a patient with idiopathic thrombocytopenic purpura. (11326563)
2001
28
Empty sella syndrome following pituitary apoplexy. (10819270)
2000
29
Pituitary apoplexy in a patient with acute myeloid leukemia and thrombocytopenia. (11141694)
2000
30
Pituitary apoplexy following mitral valve repair. (9856739)
1998
31
Pituitary apoplexy as a first manifestation of pituitary adenomas following intensive thrombolytic and antithrombotic therapy. (9462623)
1998
32
The dialysis patient with headache and sudden hypotension: consider pituitary apoplexy. (9550672)
1998
33
Osmotic demyelination syndrome in a patient with pituitary apoplexy. (8902332)
1996
34
Pituitary apoplexy after subtotal thyroidectomy in an acromegalic patient with a large goiter. (8835599)
1996
35
Pituitary apoplexy into nonadenomatous tissue: case report and review. (7631646)
1995
36
Metastatic prostatic adenocarcinoma presenting as complete ophthalmoplegia from pituitary apoplexy. (8199122)
1994
37
Sudden blindness from pituitary apoplexy: a report of two cases. (8258474)
1993
38
A case of pituitary apoplexy. (2115724)
1990
39
Intracranial arterial vasospasm associated with pituitary apoplexy after head trauma--case report. (1699153)
1990
40
Spontaneous remission of acromegaly after pituitary apoplexy following head trauma. (3209821)
1988
41
Acromegaly after pituitary apoplexy. (3560376)
1987
42
Pituitary apoplexy: an unusual cause of stroke. (3816071)
1987
43
Development of acromegaly after pituitary apoplexy. (3773218)
1986
44
Pituitary apoplexy: a review. (6369168)
1984
45
Pituitary apoplexy following chlorpromazine stimulation. (718334)
1978
46
Pituitary apoplexy. Association of degenerative change in pituitary ademona with radiotherapy and detection by cerebral computed tomography. (879188)
1977
47
A case of acromegaly improved by pituitary apoplexy. (168061)
1975
48
Regression of the Forbes-Albright syndrome after pituitary apoplexy. (4633595)
1973
49
Pituitary apoplexy. (5551489)
1971
50
Occurrence of growth-hormone deficiency in acromegaly as a result of pituitary apoplexy. (5662169)
1968

Genetic Variations for Pituitary Apoplexy

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Expression for genes affiliated with Pituitary Apoplexy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pituitary Apoplexy

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Pathways for genes affiliated with Pituitary Apoplexy

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Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN
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Compounds for genes affiliated with Pituitary Apoplexy

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Pituitary Apoplexy according to GeneCards/GeneDecks:

(show top 50)    (show all 102)
idCompoundScoreTop Affiliating Genes
1dopamine44 28 11 2412.7TRH, GNRH1
2leuprolide acetate449.7GNRH1, GH1, PRL
3cabergoline28 44 1111.7GNRH1, PRL, GH1
4hexarelin44 2810.6PRL, GH1, POMC
517-hydroxyprogesterone44 2410.6POMC, PRL, GNRH1
6pitressin449.5POMC, NPPA
7cyproteroneacetate449.4PRL, GNRH1, INS
8naltrexone44 49 28 1112.4GNRH1, GH1, POMC, PRL
9spironolactone49 44 59 28 1113.4NPPA, POMC, GNRH1
10gnrh449.4GH1, TRH, GNRH1
11opiate449.3GH1, GNRH1, POMC, PRL
12cortisone44 2410.3GH1, POMC, INS
13ghrp449.3PRL, GH1, TRH
14pyridostigmine44 1110.2TRH, PRL, GH1
15sulpiride44 28 1111.2GH1, PRL, TRH
16clomiphene citrate449.2GNRH1, INS, PRL, GH1
17fenfluramine28 44 1111.2PRL, TRH, POMC
18desmopressin44 59 28 1112.1AVP, POMC, GH1, NPPA
19metformin44 49 1111.0POMC, GH1, INS, GNRH1
20apomorphine44 28 1111.0PRL, TRH, GH1
21dhea449.0INS, GH1, PRL, POMC
22bromocriptine28 44 1111.0POMC, TRH, PRL, GNRH1
23melatonin44 59 28 11 2412.9PRL, TRH, AVP, GH1
24ribonucleic acid448.8GNRH1, GH1, PRL, POMC
25clonidine44 28 1110.8POMC, PRL, GH1, TRH
26cocaine44 119.8POMC, TRH, GNRH1, PRL
27triiodothyronine448.8POMC, TRH, GH1, PRL
28dehydroepiandrosterone sulfate448.8GH1, PRL, POMC, INS, GNRH1
29androstenedione44 249.7POMC, PRL, GH1, GNRH1, INS
30diazepam44 49 28 1111.7TRH, NPPA, POMC
31haloperidol44 28 2 49 1112.7TRH, NPPA, POMC, PRL
32norepinephrine44 11 2410.6GNRH1, POMC, AVP, TRH, PRL
33glycerol44 11 2410.6POMC, GH1, NPPA, INS
34naloxone44 49 28 1111.6POMC, TRH, PRL, GH1, GNRH1
35metoclopramide44 119.5GH1, TRH, NPPA, GNRH1, PRL
36estradiol44 11 2410.4POMC, PRL, GH1, GNRH1, TRH
37ibmx44 28 5910.4INS, TRH, GH1, NPPA
38steroid448.3GH1, GNRH1, PRL, POMC, AVP
39hydrocortisone44 2 59 1111.2POMC, GH1, INS, TRH, PRL
40epinephrine44 11 2410.2INS, POMC, PRL, GH1, NPPA, GNRH1
41progesterone44 59 28 11 2412.2TRH, POMC, GNRH1, PRL, GH1
42creatinine448.2GH1, NPPA, AVP, POMC, GNRH1, INS
43octreotide44 59 28 1110.9INS, POMC, TRH, GNRH1, PRL, GH1
44thyroxine44 248.9POMC, GH1, INS, GNRH1, PRL, TRH
45acth447.7AVP, POMC, PRL, GH1, TRH, NPPA
46glucose447.6PRL, GH1, AVP, TRH, INS, POMC
47dexamethasone44 49 28 1110.5POMC, AVP, INS, TRH, PRL, GH1
48testosterone44 59 11 2410.4INS, POMC, GNRH1, NPPA, TRH, PRL
49estrogen447.4TRH, PRL, GH1, NPPA, GNRH1, POMC
50arginine447.0AVP, PRL, NPPA, GNRH1, POMC, INS

GO Terms for genes affiliated with Pituitary Apoplexy

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16Gene Ontology
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Cellular components related to Pituitary Apoplexy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.4INS, POMC
2secretory granuleGO:0301418.4PRL, TRH, POMC, AVP
3extracellular spaceGO:0056157.5GNRH1, NPPA, GH1, POMC, INS, AVP
4extracellular regionGO:0055766.6AVP, GNRH1, NPPA, GH1, PRL, TRH

Biological processes related to Pituitary Apoplexy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.7PRL, GH1
2ovulation cycleGO:0426989.7PRL, GNRH1
3positive regulation of JAK-STAT cascadeGO:0464279.4PRL, GH1
4female pregnancyGO:0075659.3GNRH1, NPPA, PRL
5response to ethanolGO:0454718.7GNRH1, PRL, TRH, AVP
6cell-cell signalingGO:0072678.0AVP, INS, POMC, TRH, GNRH1

Molecular functions related to Pituitary Apoplexy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1prolactin receptor bindingGO:0051489.6GH1, PRL
2receptor bindingGO:0051029.1AVP, POMC, NPPA
3neuropeptide hormone activityGO:0051849.0AVP, TRH
4hormone activityGO:0051797.8INS, POMC, PRL, GH1, NPPA, GNRH1

Products for genes affiliated with Pituitary Apoplexy

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Sources for Pituitary Apoplexy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet