MCID: PTT004
MIFTS: 46

Pituitary Apoplexy malady

Categories: Endocrine diseases, Rare diseases

Aliases & Classifications for Pituitary Apoplexy

Aliases & Descriptions for Pituitary Apoplexy:

Name: Pituitary Apoplexy 12 56 52 42 14 69

Characteristics:

Orphanet epidemiological data:

56
pituitary apoplexy
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 56  
Rare endocrine diseases


External Ids:

Disease Ontology 12 DOID:1129
MeSH 42 D010899
NCIt 47 C26853
SNOMED-CT 64 237701005
Orphanet 56 ORPHA95613
MESH via Orphanet 43 D010899
UMLS via Orphanet 70 C0032001
ICD10 via Orphanet 34 E23.6
UMLS 69 C0032001

Summaries for Pituitary Apoplexy

MalaCards based summary : Pituitary Apoplexy is related to acromegaly and adenoma, and has symptoms including fatigue, fever and photophobia. An important gene associated with Pituitary Apoplexy is PRL (Prolactin), and among its related pathways/superpathways are Glucocorticoid receptor regulatory network and Signaling events mediated by PTP1B. The drugs Hormone Antagonists and Hormones have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and testes, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Wikipedia : 71 Pituitary apoplexy or pituitary tumor apoplexy is bleeding into or impaired blood supply of the... more...

Related Diseases for Pituitary Apoplexy

Diseases related to Pituitary Apoplexy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
id Related Disease Score Top Affiliating Genes
1 acromegaly 10.4
2 adenoma 10.4
3 pituitary adenoma 10.3
4 cerebritis 10.2
5 meningitis 10.2
6 aneurysm 10.2
7 endometriosis 10.1 GNRH1 PRL
8 diverticulitis 10.1 GNRH1 PRL
9 glaucoma, hereditary adult type 1a 10.1 AIP PRL
10 bowen-conradi syndrome 10.1 AIP PRL
11 hypopituitarism 10.1
12 prostatitis 10.1
13 pituitary adenoma, acth-secreting 10.1 AIP PRL
14 diabetes insipidus 10.1
15 haverhill fever 10.1 GNRH1 PRL
16 cockayne syndrome type i 10.1 INS PRL
17 growth retardation hydrocephaly lung hypoplasia 10.1 INS PRL
18 cranial nerve palsy 10.1
19 headache 10.1
20 gaucher's disease 10.1 GNRH1 PRL
21 adams-oliver syndrome 6 10.1 GNRH1 INS
22 retroperitoneal sarcoma 10.1 GNRH1 PRL
23 prostate cancer 10.0
24 hypoglycemic coma 10.0 GNRH1 INS
25 congenital tricuspid stenosis 10.0 POMC PRL
26 wheat allergy 10.0 POMC PRL
27 pancreatic colloid cystadenoma 10.0 POMC PRL
28 nonparalytic poliomyelitis 10.0 POMC PRL
29 caudal regression syndrome 10.0 POMC PRL
30 bone benign neoplasm 10.0 POMC PRL
31 lymphoma 10.0
32 glomangiomyoma 10.0 INS PRL
33 acute laryngitis 10.0 POMC PRL
34 esophagus squamous cell papilloma 10.0 POMC PRL
35 capillary disease 10.0 POMC PRL
36 rheumatic encephalitis 10.0 POMC PRL
37 benign peritoneal mesothelioma 10.0 GNRH1 POMC
38 adult i blood group with or without congenital cataract 10.0 POMC PRL
39 cone-rod dystrophy 5 10.0 AIP POMC
40 mucopolysaccharidosis type vi 10.0 POMC PRL
41 hyperlipoproteinemia type iii 10.0 INS POMC
42 bacterial meningitis 10.0
43 ptosis 10.0
44 thrombocytopenia 10.0
45 transmitted_by 9.9 POMC PRL
46 basal ganglia cerebrovascular disease 9.9 INS POMC
47 epidural spinal canal meningioma 9.9 GNRH1 INS PRL
48 papillary craniopharyngioma 9.9 GNRH1 INS PRL
49 pinguecula 9.9 GNRH1 INS PRL
50 primary biliary cirrhosis 9.9 GNRH1 INS PRL

Graphical network of the top 20 diseases related to Pituitary Apoplexy:



Diseases related to Pituitary Apoplexy

Symptoms & Phenotypes for Pituitary Apoplexy

Human phenotypes related to Pituitary Apoplexy:

56 32 (show all 43)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fatigue 56 32 Occasional (29-5%) HP:0012378
2 fever 56 32 Occasional (29-5%) HP:0001945
3 photophobia 56 32 Occasional (29-5%) HP:0000613
4 blurred vision 56 32 Occasional (29-5%) HP:0000622
5 nausea and vomiting 56 32 Frequent (79-30%) HP:0002017
6 mydriasis 56 32 Occasional (29-5%) HP:0011499
7 ptosis 56 32 Occasional (29-5%) HP:0000508
8 diplopia 56 32 Frequent (79-30%) HP:0000651
9 hypertension 56 32 Frequent (79-30%) HP:0000822
10 hypotension 56 32 Frequent (79-30%) HP:0002615
11 cranial nerve paralysis 56 32 Frequent (79-30%) HP:0006824
12 hypoglycemia 56 32 Frequent (79-30%) HP:0001943
13 pallor 56 32 Occasional (29-5%) HP:0000980
14 reduced visual acuity 56 32 Occasional (29-5%) HP:0007663
15 hypergonadotropic hypogonadism 56 32 Frequent (79-30%) HP:0000815
16 coma 56 32 Occasional (29-5%) HP:0001259
17 hyponatremia 56 32 Frequent (79-30%) HP:0002902
18 growth hormone excess 56 32 Very rare (<4-1%) HP:0000845
19 pituitary adenoma 56 32 Frequent (79-30%) HP:0002893
20 impotence 56 32 Frequent (79-30%) HP:0000802
21 galactorrhea 56 32 Occasional (29-5%) HP:0100829
22 pituitary hypothyroidism 56 32 Frequent (79-30%) HP:0008245
23 confusion 56 32 Very rare (<4-1%) HP:0001289
24 abnormality of the cerebrospinal fluid 56 32 Occasional (29-5%) HP:0002921
25 adrenocorticotropic hormone deficiency 56 32 Frequent (79-30%) HP:0011748
26 bitemporal hemianopia 56 32 Very frequent (99-80%) HP:0030521
27 abnormal kinetic perimetry test 56 32 Frequent (79-30%) HP:0030591
28 prolactin excess 56 32 Occasional (29-5%) HP:0000870
29 growth hormone deficiency 56 32 Occasional (29-5%) HP:0000824
30 central diabetes insipidus 56 32 Very rare (<4-1%) HP:0000863
31 oligomenorrhea 56 32 Frequent (79-30%) HP:0000876
32 trigeminal neuralgia 56 32 Very rare (<4-1%) HP:0100661
33 prolactin deficiency 56 32 Frequent (79-30%) HP:0008202
34 thunderclap headache 56 32 Very frequent (99-80%) HP:0030907
35 normochromic anemia 56 32 Very rare (<4-1%) HP:0001895
36 abnormal static automated perimetry test 56 32 Frequent (79-30%) HP:0030595
37 abnormality of the caudate nucleus 56 32 Very rare (<4-1%) HP:0002339
38 headache 56 Frequent (79-30%)
39 excessive daytime somnolence 32 HP:0001262
40 hypercortisolism 56 Very rare (<4-1%)
41 somnolence 56 Very rare (<4-1%)
42 increased circulating cortisol level 32 HP:0003118
43 hypopituitarism 56 Occasional (29-5%)

MGI Mouse Phenotypes related to Pituitary Apoplexy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.72 AIP GNRH1 INS POMC PRL
2 homeostasis/metabolism MP:0005376 9.65 PRL AIP GNRH1 INS POMC
3 integument MP:0010771 9.55 AIP GNRH1 INS POMC PRL
4 liver/biliary system MP:0005370 9.35 AIP GNRH1 INS POMC PRL
5 neoplasm MP:0002006 8.92 AIP GNRH1 POMC PRL

Drugs & Therapeutics for Pituitary Apoplexy

Drugs for Pituitary Apoplexy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormone Antagonists Phase 4,Early Phase 1
2 Hormones Phase 4,Early Phase 1
3 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Early Phase 1
4
Oxytocin Approved, Vet_approved Phase 2 50-56-6 439302 53477758
5 Oxytocics Phase 2
6
Hydrocortisone Approved, Vet_approved 50-23-7 5754 657311
7
Zinc Approved 7440-66-6 32051 23994
8
Butyric Acid Experimental 107-92-6 264
9 Anti-Inflammatory Agents
10 Cortisol succinate
11 Gastrointestinal Agents
12 glucagon
13 Glucagon-Like Peptide 1
14 Hydrocortisone 17-butyrate 21-propionate
15 Hydrocortisone acetate
16 Hydrocortisone-17-butyrate
17 Hypoglycemic Agents
18 Incretins
19 insulin
20 Insulin, Globin Zinc
21 Adrenocorticotropic Hormone Early Phase 1
22 Corticotropin-Releasing Hormone Early Phase 1
23 Mitogens
24 Growth Hormone-Releasing Hormone
25 arginine Nutraceutical

Interventional clinical trials:

(show all 16)
id Name Status NCT ID Phase
1 Changes of Left Ventricular Mass and Cardiac Function in Patients With Active Acromegaly During Treatment With the Growth Hormone Receptor Antagonist Pegvisomant Unknown status NCT00552851 Phase 4
2 The Penumbra Liberty Trial: Safety and Effectiveness in the Treatment of Wide-Neck Intracranial Aneurysms Active, not recruiting NCT01636453 Phase 3
3 An Efficacy Study of Vagitocin in Postmenopausal Women With Symptoms of Vaginal Atrophy Completed NCT02497547 Phase 2
4 Pegvisomant With Glucagon Test to Assess for Adult Growth Hormone Deficiency Unknown status NCT01804413
5 Evaluation of Factors in Human Brain Tumors Completed NCT00001171
6 Pelvic Pain in Women With Endometriosis Completed NCT00073801
7 Cardiac and Skeletal Muscle Energy Metabolism in Abnormal Growth Hormone States Completed NCT00461240
8 Prevalence of a High-intensity Signal of the Oculomotor Nerve on T2 MRI Sequence in Patients With Ophthalmoplegia Recruiting NCT03135574
9 Effects of Hormone Stimulation on Brain Scans for Cushing s Disease Recruiting NCT01459237 Early Phase 1
10 Prospective Study of Clinically Nonfunctioning Pituitary Adenomas Recruiting NCT01556230
11 Evaluation and Treatment of Neurosurgical Disorders Recruiting NCT00060541
12 Late Effects of Radiosurgery on Acromegaly Study Recruiting NCT02296216
13 Testing the Developmental Origins Hypothesis Recruiting NCT01545492
14 Cardiac (CMRI) Assessment of Acromegaly Recruiting NCT02948322
15 Cushing´s Disease Epidemiology in Sweden Active, not recruiting NCT02350153
16 Adult Growth Hormone Deficiency and Cardiovascular Risk Terminated NCT00720902

Search NIH Clinical Center for Pituitary Apoplexy

Cochrane evidence based reviews: pituitary apoplexy

Genetic Tests for Pituitary Apoplexy

Anatomical Context for Pituitary Apoplexy

MalaCards organs/tissues related to Pituitary Apoplexy:

39
Pituitary, Brain, Testes, Prostate, Caudate Nucleus, Thyroid, Lung

Publications for Pituitary Apoplexy

Articles related to Pituitary Apoplexy:

(show top 50) (show all 539)
id Title Authors Year
1
Pituitary Apoplexy Mimicking Bacterial Meningitis with Intracranial Hypertension. ( 27756666 )
2017
2
A case of pituitary apoplexy masquerading as subarachnoid hemorrhage. ( 27014446 )
2016
3
Pituitary Apoplexy After Initial Leuprolide Injection. ( 27586180 )
2016
4
Management of pituitary apoplexy. ( 27006559 )
2016
5
Pituitary Apoplexy Associated with Carotid Compression and a Large Ischemic Penumbra. ( 27319311 )
2016
6
Poster 329 Rehabilitation of Horizontal Diplopia due to Abducens Nerve Palsy in an Idiopathic Pituitary Apoplexy: A Case Report. ( 27673084 )
2016
7
Pituitary apoplexy complicated by vasospasm and bilateral cerebral infarction. ( 27329099 )
2016
8
Prolactinoma and pregnancy - a series of cases including pituitary apoplexy. ( 27866462 )
2016
9
Pituitary apoplexy: considerations on a single center experience and review of the literature. ( 26733212 )
2016
10
Pituitary apoplexy presenting as diabetic ketoacidosis: A great simulator? Case Report. ( 26994379 )
2016
11
A pediatric case of pituitary macroadenoma presenting with pituitary apoplexy and cranial nerve involvement: case report. ( 27738402 )
2016
12
Pituitary Apoplexy- Bespoke Patient Management Allows Good Clinical Outcome. ( 27038242 )
2016
13
Pituitary apoplexy as presentation of atypical teratoid/rhabdoid tumor in an adult. ( 27349334 )
2016
14
Pituitary tuberculoma: A consideration in the differential diagnosis in a patient manifesting with pituitary apoplexy-like syndrome. ( 27516966 )
2016
15
Pituitary apoplexy causing spontaneous remission of acromegaly following long-acting octreotide therapy: a rare drug side effect or just a coincidence. ( 27123308 )
2016
16
Multidisciplinary Management of Pituitary Apoplexy. ( 28074095 )
2016
17
Spontaneous pituitary apoplexy during the second trimester of pregnancy, with sensory loss. ( 26884071 )
2016
18
SOCIETY FOR ENDOCRINOLOGY ENDOCRINE EMERGENCY GUIDANCE: Emergency management of pituitary apoplexy in adult patients. ( 27935817 )
2016
19
A primer on pituitary injury for the obstetrician gynecologist: Simmonds disease, Sheehan's syndrome, Traumatic injury, Dahan' s syndrome, Pituitary Apoplexy and Lymphocytic Hypophysitis. ( 27405776 )
2016
20
Third, Fourth, and Sixth Cranial Nerve Palsies in Pituitary Apoplexy. ( 27436207 )
2016
21
PITUITARY APOPLEXY DUE TO DAIGNOSTIC TEST IN CUSHING'S DISEASE PATIENT. ( 27593808 )
2016
22
Primary immune thrombocytopenia accompanied by pituitary apoplexy. ( 27498733 )
2016
23
Surgical versus non-surgical treatment for pituitary apoplexy: A systematic review and meta-analysis. ( 27772771 )
2016
24
Gonadotropin-releasing hormone agonist-induced pituitary apoplexy. ( 27284452 )
2016
25
Pituitary apoplexy masquerading as functional decline in an older person. ( 27810852 )
2016
26
Pituitary apoplexy causing clival and spinal haematoma. ( 26743947 )
2016
27
Epistaxis and pituitary apoplexy due to ruptured internal carotid artery aneurysm embedded within pituitary adenoma. ( 26823732 )
2015
28
Pituitary apoplexy presenting with anorexia and hyponatraemia. ( 25858941 )
2015
29
Postpartum pituitary apoplexy with isolated oculomotor nerve palsy: A rare medical emergency. ( 26752912 )
2015
30
A case of pituitary apoplexy following posterior lumbar fusion surgery. ( 26252784 )
2015
31
Pituitary Apoplexy After Intravitreal Injection of Vascular Endothelial Growth Factor Inhibitor: A Novel Complication. ( 26623228 )
2015
32
Recurrent pituitary apoplexy due to two successive neoplasms presenting with ocular paresis and epistaxis. ( 25755879 )
2015
33
Incidence of Pituitary Apoplexy and Its Risk Factors in Chinese People: A Database Study of Patients with Pituitary Adenoma. ( 26407083 )
2015
34
Management and outcomes of pituitary apoplexy. ( 25859804 )
2015
35
Spontaneous retroclival hematoma in pituitary apoplexy: case series. ( 26140487 )
2015
36
Isolated abducens nerve palsy due to pituitary apoplexy after mild head trauma. ( 26314216 )
2015
37
Spontaneous remission of acromegaly and Cushing&rsquo;s disease following pituitary apoplexy: Two case reports. ( 26087804 )
2015
38
Pituitary apoplexy presenting with bilateral oculomotor nerve palsy. ( 26475871 )
2015
39
Endoscopic Endonasal Transsphenoidal Treatment of Pituitary Apoplexy: Outcomes in a Series of 20 Patients. ( 26623212 )
2015
40
Rapid pituitary apoplexy regression: what is the time course of clot resolution? ( 25861507 )
2015
41
Pituitary apoplexy following gonadotropin-releasing hormone agonist administration with gonadotropin-secreting pituitary adenoma. ( 25455737 )
2015
42
Pituitary apoplexy in pregnancy: A case series and literature review. ( 27512477 )
2015
43
Pituitary apoplexy in a pregnant woman with cystic microprolactinoma. ( 25732323 )
2015
44
Pituitary apoplexy induced by triptorelin in patient with prostate cancer. ( 26184059 )
2015
45
Pituitary apoplexy following mitral valvuloplasty. ( 25932297 )
2015
46
Pituitary apoplexy: pathophysiology, diagnosis and management. ( 26154095 )
2015
47
On the Origins of Pituitary Apoplexy. ( 26111492 )
2015
48
Surgical treatment of pituitary apoplexy in association with hemispheric infarction. ( 26213287 )
2015
49
An unexpected headache: pituitary apoplexy in a pregnant woman on anticoagulation. ( 26002671 )
2015
50
Pituitary apoplexy. ( 25732655 )
2015

Variations for Pituitary Apoplexy

Expression for Pituitary Apoplexy

Search GEO for disease gene expression data for Pituitary Apoplexy.

Pathways for Pituitary Apoplexy

Pathways related to Pituitary Apoplexy according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.87 POMC PRL
2 10.32 INS PRL

GO Terms for Pituitary Apoplexy

Cellular components related to Pituitary Apoplexy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 secretory granule lumen GO:0034774 9.16 INS POMC
2 secretory granule GO:0030141 8.96 POMC PRL
3 endosome lumen GO:0031904 8.62 INS PRL

Biological processes related to Pituitary Apoplexy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to organic cyclic compound GO:0014070 9.32 GNRH1 PRL
2 response to ethanol GO:0045471 9.26 GNRH1 PRL
3 female pregnancy GO:0007565 9.16 GNRH1 PRL
4 cell-cell signaling GO:0007267 9.13 GNRH1 INS POMC
5 ovulation cycle GO:0042698 8.62 GNRH1 PRL

Molecular functions related to Pituitary Apoplexy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.92 GNRH1 INS POMC PRL

Sources for Pituitary Apoplexy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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