Pituitary Apoplexy malady

Wikipedia: Pituitary apoplexy or pituitary tumor apoplexy is bleeding into or impaired blood supply of the...⁴⁴ more...

MalaCards: Pituitary Apoplexy, also known as pituitary apoplexy (disorder), is related to prolactinoma and sinusitis. An important gene associated with Pituitary Apoplexy is GNRH1 (gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)), and among its related pathways are G alpha (s) signalling events and mTOR Pathway. The compounds glucose and testosterone have been mentioned in the context of this disorder. Affiliated tissues include brain, thyroid and adrenal gland, and related mouse phenotypes are liver/biliary system and adipose tissue.

Aliases & Descriptions:

pituitary apoplexy 6 8 32 43 pituitary apoplexy (disorder) 6

Diseases related to pituitary apoplexy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 241)

id	Related Disease	Score	Top Affiliating Genes
1	prolactinoma	26.6	INS, GNRH1, GH1, TRH, PRL, POMC
2	sinusitis	26.3	AVP, INS, GH1, PRL, POMC, NPPA
3	thyroiditis	25.6	INS, GNRH1, GH1, TRH, PRL, POMC
4	hypopituitarism	25.5	BRD2, AVP, INS, GNRH1, GH1, TRH
5	adenoma	25.1	BRD2, INS, GNRH1, GH1, TRH, PRL
6	carcinoma	24.5	BRD2, AVP, INS, GNRH1, GH1, TRH
7	fragile x-associated primary ovarian insufficiency	13.3	GNRH1, PRL
8	penis paget's disease	13.3	BRD2, PRL
9	sexual disorder	13.2	BRD2, PRL
10	generalized resistance to thyroid hormone	13.2	TRH, PRL
11	delayed puberty	13.2	GNRH1, PRL
12	impotence	13.2	GNRH1, PRL
13	premature ovarian failure	13.2	GNRH1, PRL
14	robinow syndrome	13.2	GNRH1, GH1
15	tsh producing pituitary tumor	13.2	GH1, PRL
16	chromophobe adenoma	13.2	GH1, PRL
17	hyperthyroxinemia	13.2	TRH, PRL
18	y chromosome infertility	13.2	GNRH1, PRL
19	pituitary gland disease	13.1	GH1, PRL
20	mccune albright syndrome	13.1	GH1, PRL
21	empty sella syndrome	13.1	GH1, PRL
22	fetal adenoma	13.1	GH1, PRL
23	spinocerebellar degeneration	13.1	TRH, PRL
24	somatotrophinoma	13.1	GH1, PRL
25	arachnoid cysts	13.1	GNRH1, GH1
26	tetrahydrobiopterin deficiency	13.1	GH1, PRL
27	granulosa cell tumor of the ovary	13.1	INS, PRL
28	borderline personality disorder	13.1	TRH, PRL
29	androgenetic alopecia	13.0	INS, PRL
30	transsexualism	13.0	GNRH1, PRL
31	germinoma	13.0	AVP, PRL
32	testicular disease	13.0	BRD2, GNRH1, PRL
33	growth hormone secreting pituitary adenoma	13.0	GH1, PRL
34	myxedema	13.0	AVP, NPPA
35	rabson-mendenhall syndrome	13.0	INS, GH1
36	varicocele	12.9	BRD2, GNRH1, PRL
37	enuresis	12.9	AVP, NPPA
38	hypersomnia	12.9	INS, GH1
39	myelomeningocele	12.9	GNRH1, TRH, PRL
40	laron syndrome	12.9	INS, GH1
41	hypothalamic disease	12.9	GNRH1, GH1, PRL
42	hypothalamic hamartomas	12.9	INS, GNRH1, PRL
43	gonadotropin deficiency	12.9	GNRH1, GH1, PRL
44	postural hypotension	12.8	INS, NPPA
45	dumping syndrome	12.8	INS, NPPA
46	lymphocytic hypophysitis	12.8	PRL, POMC
47	nelson syndrome	12.8	PRL, POMC
48	adrenal gland hyperfunction	12.8	AVP, INS, PRL
49	arachnoiditis	12.8	GNRH1, GH1
50	abrikosov's tumor	12.8	INS, GNRH1, PRL

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to pituitary apoplexy:

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MGI Mouse Phenotypes related to pituitary apoplexy:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system phenotype	MP:0005370	8.2	PRL, GH1, GNRH1, INS, BRD2
2	adipose tissue phenotype	MP:0005375	8.2	BRD2, INS, GH1, POMC
3	renal/urinary system phenotype	MP:0005367	7.5	NPPA, POMC, GNRH1, INS, AVP
4	nervous system phenotype	MP:0003631	7.2	POMC, PRL, TRH, GNRH1, INS, AVP
5	endocrine/exocrine gland phenotype	MP:0005379	7.1	POMC, PRL, TRH, GH1, GNRH1, INS
6	homeostasis/metabolism phenotype	MP:0005376	6.2	BRD2, NPPA, POMC, PRL, TRH, GH1

Articles related to pituitary apoplexy:

(show all 12)

id	Title	Authors	Year	Affiliating Genes
1	A case of macroprolactinoma encasing an internal carotid artery aneurysm, presenting as pituitary apoplexy. (17899387)	Soni A.... Wass J.A.	2008	PRL
2	A case of ruptured internal carotid artery aneurysm mimicking pituitary apoplexy (18080517)	Okawara M.... Okawara S.	2007	PRL
3	Pituitary apoplexy after leuprolide. (16832587)	Davis A.... Lavis V.	2006	GNRH1
4	Pituitary apoplexy due to prolactinoma in a Taiwanese boy: patient report and review of the literature. (14714755)	Yang M.H.... Lo F.S.	2003	PRL
5	Corticotroph cell adenoma without typical manifestations of Cushing's disease presenting with cavernous sinus syndrome following pituitary apoplexy. (11603575)	Abe M.... Sano T.	2001	POMC, GH1
6	Gonadotropin-releasing hormone-induced partial empty sella clinically mimicking pituitary apoplexy in a woman with a suspected non-s ecreting macroadenoma. (10800766)	Foppiani L.... Giusti M.	2000	GNRH1
7	Symptoms of pituitary apoplexy rapidly reversed with bromocriptine. Case report. (8929510)	Brisman M.H.... Post K.D.	1996	PRL
8	Pituitary apoplexy after leuprolide administration for carcinoma of the prostate. (8706284)	Morsi A.... Silverberg J.D.	1996	GNRH1
9	Pituitary apoplexy after pituitary function test: a report of two cases and review of the literature. (7892662)	Masago A.... Umemura S.	1995	INS, GNRH1
10	Pituitary apoplexy: analysis of endocrine function in 17 cases (2051802)	FernA!ndez Real J.M.... Soler J.	1991	PRL, INS
11	An unusual association of transient resolving thyrot oxicosis due to painless thyroiditis, hypopituitarism and central diabetes insi pidus associated with spontaneous pituitary apoplexy (2307257)	Sasaki H.... Okumura M.	1990	GH1
12	An interesting case of pituitary apoplexy showing abnormality in water-electrolyte before and after surgery (2149644)	Morinaga K.... Okawara S.	1990	AVP, NPPA

Genes related to pituitary apoplexy according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	GNRH1	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)	11.0	Publications
2	PRL	prolactin	11.0	Publications
3	AVP	arginine vasopressin	11.0	Publications
4	TRH	thyrotropin-releasing hormone	11.0
5	BRD2	bromodomain containing 2	11.0
6	GH1	growth hormone 1	11.0	Publications
7	NPPA	natriuretic peptide A	11.0	Publications
8	POMC	proopiomelanocortin	11.0	Publications
9	INS	insulin	11.0	Publications

Pathways related to pituitary apoplexy according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	G alpha (s) signalling events38	9.3	AVP, POMC
2	mTOR Pathway36	9.2	INS, GNRH1, GH1
3	Development_Leptin signaling via JAK/STAT and MAPK cascades41	9.1	POMC, TRH
4	eIF2 Pathway36	9.1	INS, GNRH1, GH1
5	Development Leptin signaling via JAK/STAT and MAPK cascades10	8.9	POMC, TRH

Compounds related to pituitary apoplexy according to GeneDecks:

(show top 50)    (show all 99)

id	Compound	Score	Top Affiliating Genes
1	glucose32	9.8	AVP, TRH
2	testosterone32 9 18 9	12.8	PRL, TRH, GNRH1
3	haloperidol32 34 9 9	12.8	TRH, NPPA
4	quinagolide32	9.6	GH1, PRL
5	leuprolide acetate32	9.6	PRL, GNRH1, GH1
6	cabergoline32 9 9	11.6	GH1, PRL, GNRH1
7	ghrp32	9.6	PRL, TRH, GH1
8	pyridostigmine32 9 9	11.6	TRH, PRL, GH1
9	cyproteroneacetate32	9.5	INS, PRL, GNRH1
10	sulpiride32 9 9	11.5	GH1, PRL, TRH
11	creatinine32	9.5	POMC, GH1
12	apomorphine32 9 9	11.4	PRL, GH1, TRH
13	fenfluramine32 9 9	11.2	TRH, POMC, PRL
14	17-hydroxyprogesterone32 18	10.2	PRL, GNRH1, POMC
15	estradiol32 9 18 9	12.2	TRH, PRL, POMC
16	clomiphene citrate32	9.2	GNRH1, PRL, GH1, INS
17	melatonin32 42 9 18 9	13.2	AVP, GH1, TRH, PRL
18	hexarelin32	9.1	GH1, PRL, POMC
19	pitressin32	8.9	NPPA, POMC
20	spironolactone32 42 34 9 9	12.9	NPPA, GNRH1, POMC
21	naltrexone32 34 9 9	11.9	PRL, GNRH1, GH1, POMC
22	cortisone32 18	9.9	INS, GH1, POMC
23	opiate32	8.8	GH1, POMC, GNRH1, PRL
24	cocaine32 9 9	10.8	POMC, PRL, GNRH1, TRH
25	clonidine32 9 9	10.8	POMC, TRH, PRL, GH1
26	triiodothyronine32	8.7	POMC, GH1, TRH, PRL
27	ibmx32	8.7	INS, GH1, TRH, NPPA
28	metoclopramide32 9 9	10.7	GH1, GNRH1, NPPA, PRL, TRH
29	metformin32 34 9 9	11.7	GNRH1, GH1, POMC, INS
30	dhea32	8.6	POMC, PRL, GH1, INS
31	gnrh32	8.6	POMC, GH1, TRH, INS
32	diazepam32 34 9 9	11.6	TRH, NPPA, POMC
33	desmopressin32 42 9 9	11.5	POMC, GH1, AVP, NPPA
34	bromocriptine32 9 9	10.5	PRL, GH1, TRH, POMC, GNRH1
35	naloxone32 34 9 9	11.5	GH1, TRH, PRL, GNRH1, POMC
36	dehydroepiandrosterone sulfate32	8.4	GNRH1, POMC, INS, GH1, PRL
37	androstenedione32 18	9.4	INS, GH1, PRL, POMC, GNRH1
38	hydrocortisone32 9 9	10.3	INS, GH1, TRH, PRL, POMC
39	ribonucleic acid32	8.2	POMC, PRL, GH1, GNRH1
40	progesterone32 42 9 18 9	12.1	GH1, GNRH1, POMC, TRH, PRL
41	glycerol32 9 18 9	11.1	NPPA, POMC, GH1, INS
42	octreotide32 42 9 9	11.0	POMC, TRH, PRL, GH1, GNRH1, INS
43	thyroxine32 18	9.0	PRL, GH1, POMC, GNRH1, INS, TRH
44	dopamine32 9 18 9	10.8	GNRH1, NPPA, PRL, GH1, POMC, TRH
45	epinephrine32 9 18 9	10.7	INS, NPPA, GNRH1, GH1, POMC, PRL
46	dexamethasone32 42 34 9 9	11.6	TRH, POMC, INS, AVP, PRL, GNRH1
47	estrogen32	7.3	NPPA, POMC, PRL, GH1, GNRH1, INS
48	acth32	7.0	TRH, GH1, INS, AVP, PRL, POMC
49	norepinephrine32 9 18 9	10.0	GH1, GNRH1, PRL, POMC, TRH, NPPA
50	arginine32	7.0	GH1, INS, GNRH1, TRH, PRL, POMC

Cellular components related to pituitary apoplexy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	secretory granule	GO:030141	8.0	POMC, TRH, INS, AVP
2	extracellular space	GO:005615	7.9	AVP, INS, GNRH1, GH1, POMC
3	extracellular region	GO:005576	6.4	AVP, NPPA, POMC, PRL, TRH, GH1

Biological processes related to pituitary apoplexy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	JAK-STAT cascade involved in growth hormone signaling pathway	GO:060397	9.6	GH1, PRL
2	positive regulation of JAK-STAT cascade	GO:046427	9.3	GH1, PRL
3	response to ethanol	GO:045471	9.3	AVP, GNRH1, TRH
4	female pregnancy	GO:007565	9.2	NPPA, PRL, GNRH1
5	cell-cell signaling	GO:007267	8.1	AVP, INS, GNRH1, TRH, POMC

Molecular functions related to pituitary apoplexy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	neuropeptide hormone activity	GO:005184	9.7	AVP, TRH
2	prolactin receptor binding	GO:005148	9.3	GH1, PRL
3	hormone activity	GO:005179	7.2	INS, NPPA, POMC, PRL, GH1, GNRH1