MCID: PTT004
MIFTS: 46

Pituitary Apoplexy malady

Endocrine diseases, Rare diseases categories

Aliases & Classifications for Pituitary Apoplexy

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Pituitary Apoplexy, Aliases & Descriptions:

Name: Pituitary Apoplexy 9 11 43 47 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Endocrine diseases


Characteristics (Orphanet epidemiological data):

47
pituitary apoplexy:
Inheritance: Not applicable; Age of onset: All ages


External Ids:

Disease Ontology9 DOID:1129
MeSH33 D010899
NCIt38 C26853
Orphanet47 95613
SNOMED-CT55 237701005
MESH via Orphanet34 D010899
ICD10 via Orphanet26 E23.0
UMLS via Orphanet61 C0032001

Summaries for Pituitary Apoplexy

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Wikipedia:63 Pituitary apoplexy or pituitary tumor apoplexy is bleeding into or impaired blood supply of the... more...

MalaCards based summary: Pituitary Apoplexy is related to empty sella syndrome and thyroiditis. An important gene associated with Pituitary Apoplexy is GNRH1 (gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)), and among its related pathways are Nuclear signaling by ERBB4 and Growth hormone receptor signaling. The compounds leuprolide acetate and cabergoline have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and testes, and related mouse phenotypes are tumorigenesis and renal/urinary system.

Related Diseases for Pituitary Apoplexy

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Diseases related to Pituitary Apoplexy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1empty sella syndrome31.0GH1, PRL
2thyroiditis30.8POMC, TRH
3diabetes insipidus30.8AVP, PRL, POMC, TRH
4thyrotoxicosis30.8INS, TRH
5chromophobe adenoma30.7PRL, GH1
6cushing's syndrome30.5GH1, POMC
7pituitary adenoma30.5TRH, AIP, GNRH1, POMC, PRL, GH1
8gigantism30.3AIP, GH1, PRL
9prolactinoma30.1POMC, PRL, GH1, TRH, GNRH1, AIP
10acromegaly30.1PRL, TRH, GH1, POMC, GNRH1, INS
11adenoma30.0GNRH1, TRH, POMC, PRL, INS, GH1
12hyperglycemia29.9INS, POMC, GH1
13amenorrhea29.8INS, GNRH1, POMC, PRL, TRH
14hypopituitarism29.8TRH, POMC, GNRH1, INS, AVP, PRL
15growth hormone deficiency29.8POMC, PRL, INS, GH1
16pituitary tumors29.7POMC, TRH, PRL, GNRH1, AIP, GH1
17hypoglycemia29.1AVP, INS, GNRH1, POMC, PRL, GH1
18cerebritis10.7
19meningitis10.7
20aneurysm10.6
21blindness10.6
22prostatitis10.6
23cranial nerve palsy10.5
24headache10.5
25prostate cancer10.5
26exophthalmos10.5TRH
27hyperthyroxinemia10.5TRH
28euthyroid sick syndrome10.5TRH
29turner syndrome10.5GNRH1
30congestive heart failure10.4AVP
31hypoaldosteronism10.4POMC
32laron dwarfism10.4GH1
33ptosis10.4
34dumping syndrome10.4NPPA
35penile disease10.4PRL, GNRH1
36sexual disorder10.4PRL, GNRH1
37hypogonadotropism10.4GNRH1, PRL
38dengue hemorrhagic fever10.4
39thrombocytopenia10.4
40carotid artery occlusion10.4
41bacterial meningitis10.4
42functioning pituitary adenoma10.4
43ophthalmoplegia10.4
44hemorrhagic fever10.4
45non-functioning pituitary adenoma10.4
46varicocele10.4GNRH1, PRL
47ovarian disease10.3PRL, GNRH1
48premature ovarian failure10.3PRL, GNRH1
49mccune-albright syndrome, somatic, mosaic10.3PRL, GH1
50pituitary gland disease10.3GH1, PRL

Graphical network of the top 20 diseases related to Pituitary Apoplexy:



Diseases related to pituitary apoplexy

Symptoms for Pituitary Apoplexy

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Drugs & Therapeutics for Pituitary Apoplexy

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Drug clinical trials:

Search ClinicalTrials for Pituitary Apoplexy

Search NIH Clinical Center for Pituitary Apoplexy

Genetic Tests for Pituitary Apoplexy

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Anatomical Context for Pituitary Apoplexy

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MalaCards organs/tissues related to Pituitary Apoplexy:

31
Pituitary, Brain, Testes, Prostate, Thyroid, Liver, Lung, Myeloid, Eye, Heart, B cells

Animal Models for Pituitary Apoplexy or affiliated genes

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MGI Mouse Phenotypes related to Pituitary Apoplexy:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5PRL, POMC, GNRH1, AIP
2MP:00053678.2AVP, INS, GNRH1, POMC, NPPA
3MP:00107717.8AIP, INS, GNRH1, POMC, PRL
4MP:00053707.6AIP, INS, GNRH1, POMC, PRL, GH1
5MP:00036317.5AVP, INS, GNRH1, POMC, PRL, GH1
6MP:00053797.1AIP, INS, GNRH1, POMC, PRL, GH1
7MP:00053787.0AIP, INS, GNRH1, POMC, GH1, TRH
8MP:00053766.3TRH, AVP, AIP, INS, GNRH1, POMC

Publications for Pituitary Apoplexy

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Articles related to Pituitary Apoplexy:

(show top 50)    (show all 493)
idTitleAuthorsYear
1
Presentation, management and outcomes in acute pituitary apoplexy: a large single-centre experience from the United Kingdom. (23909507)
2013
2
A case of acromegaly complicated with diabetic ketoacidosis, pituitary apoplexy, and lymphoma. (24296058)
2013
3
Pituitary apoplexy. A case report. (22520169)
2013
4
Pituitary apoplexy associated with cabergoline therapy. (24113159)
2013
5
Pituitary apoplexy caused by hemorrhage from pituitary metastatic melanoma: case report. (24077271)
2013
6
Sellar and parasellar intravascular lymphoma mimicking pituitary apoplexy. (22173269)
2012
7
An unusual case of sudden onset headache due to pituitary apoplexy: a case report and review of the new UK guidelines. (22693695)
2012
8
Pituitary apoplexy presenting atypical time course of ophthalmic symptoms. (22576705)
2012
9
Pituitary metastasis presenting as ischemic pituitary apoplexy following heparin-induced thrombocytopenia. (23129546)
2012
10
Pituitary apoplexy. (21415110)
2011
11
Pituitary apoplexy can mimic acute meningoencephalitis or subarachnoid haemorrhage. (21975129)
2011
12
Manifestation of a sellar hemangioblastoma due to pituitary apoplexy: a case report. (21970745)
2011
13
Pituitary apoplexy. (22029023)
2011
14
Pituitary apoplexy following coronary artery bypass grafting: report of a case. (20919675)
2010
15
Development of pituitary apoplexy during TRH/GnRH test in a patient with pituitary macroadenoma. (21140103)
2010
16
Isolated unilateral abducens cranial nerve palsy: a rare presentation of pituitary apoplexy. (19882540)
2010
17
Pituitary abscess with panhypopituitarism showing T1 signal hyperintensity of the marginal pituitary area: a non-invasive differential diagnosis of pituitary abscess and pituitary apoplexy. (19293544)
2009
18
Hypothalamic lymphoma with symptoms mimicking pituitary apoplexy. (19293554)
2009
19
Primary central nervous system lymphoma mimicking pituitary apoplexy: case report. (18205050)
2009
20
Extensive spherical amyloid deposition of pituitary adenoma presenting as pituitary apoplexy. (18280642)
2008
21
A case of macroprolactinoma encasing an internal carotid artery aneurysm, presenting as pituitary apoplexy. (17899387)
2008
22
Blindness following pituitary apoplexy: timing of surgery and neuro-ophthalmic outcome. (18502643)
2008
23
Transient central diabetes insipidus followed by pituitary apoplexy treated in a conservative way. (18641885)
2008
24
Pituitary apoplexy and CABG: should we change our strategy? (17889010)
2007
25
Optic tract hemorrhage after pituitary apoplexy. (17213443)
2007
26
Perirolandic sparing and pituitary apoplexy in adult brain with global hypoxia. A case report. (24299937)
2007
27
Pituitary apoplexy after aortic abdominal aneurysm surgery: a case report. (16612920)
2006
28
Pituitary apoplexy after leuprolide. (16832587)
2006
29
Pituitary apoplexy and idiopathic thrombocytopenic purpura: a new case and review of the literature. (16328568)
2004
30
Cerebral infarction following pituitary apoplexy--case report. (15600283)
2004
31
Pituitary apoplexy presenting as unilateral third cranial nerve palsy after coronary artery bypass surgery. (14693581)
2004
32
Coexistence of aneurysmal subarachnoid haemorrhage and pituitary apoplexy: Case report and review of the literature. (12852891)
2003
33
Suspected pituitary apoplexy in a German shorthaired pointer. (14635962)
2003
34
Pituitary apoplexy presenting as postoperative stupor. (11839866)
2002
35
Perioperative management of a patient requiring surgery for pituitary apoplexy and severe angina pectoris. (11094603)
2000
36
Spontaneous haemorrhage into an empty sella turcica mimicking pituitary apoplexy. (11029243)
2000
37
Subacute pituitary apoplexy-analysis of 17 cases. (10089716)
1999
38
Acute painful oculomotor nerve paresis caused by pituitary apoplexy--a case report. (10465926)
1999
39
Pituitary apoplexy after spinal anaesthesia. (9924246)
1998
40
Pituitary apoplexy after leuprolide administration for carcinoma of the prostate. (8706284)
1996
41
A retrospective analysis of pituitary apoplexy. (8232799)
1993
42
Pituitary apoplexy and the conflicting perioperative goals of anticoagulation and hemostasis. (8452252)
1993
43
Pituitary apoplexy: endocrine, surgical and oncological emergency. Incidence, clinical course and treatment with reference to 799 cases of pituitary adenomas. (8460561)
1993
44
Pituitary apoplexy in a patient with prolactinoma following computerized tomography scan. (1341487)
1992
45
Visual recovery after blindness from pituitary apoplexy. (2178757)
1990
46
Pituitary apoplexy after combined test of anterior pituitary function. (3926050)
1985
47
Pituitary apoplexy. (3926251)
1985
48
Pituitary apoplexy: a review. (6369168)
1984
49
Pituitary apoplexy. The importance of skull roentgenograms and computerized tomography in diagnosis. (7382057)
1980
50
A case of acromegaly improved by pituitary apoplexy. (168061)
1975

Variations for Pituitary Apoplexy

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Expression for genes affiliated with Pituitary Apoplexy

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Search GEO for disease gene expression data for Pituitary Apoplexy.

Pathways for genes affiliated with Pituitary Apoplexy

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Pathways related to Pituitary Apoplexy according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7PRL, GH1
29.7PRL, GH1
39.5PRL, INS
4
Show member pathways
9.5TRH, POMC
5
Show member pathways
9.3TRH, GNRH1, AVP
6
Show member pathways
9.1INS, GNRH1, GH1
7
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling58
Leptin signaling pathway36
9.1GH1, PRL, INS
89.1GH1, PRL, INS
9
Show member pathways
9.0INS, POMC, GH1
10
Show member pathways
8.8INS, GNRH1, PRL, GH1
11
Show member pathways
8.0TRH, GH1, PRL, POMC, GNRH1, AVP
12
Show member pathways
7.4AVP, INS, GNRH1, POMC, PRL, GH1

Compounds for genes affiliated with Pituitary Apoplexy

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Compounds related to Pituitary Apoplexy according to GeneCards Suite gene sharing:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
1leuprolide acetate439.7GNRH1, PRL, GH1
2cabergoline43 28 1211.6GNRH1, PRL, GH1
3hexarelin43 2810.6POMC, PRL, GH1
417-hydroxyprogesterone43 2410.6PRL, POMC, GNRH1
5ghrp439.6GH1, PRL, TRH
6pyridostigmine43 1210.5PRL, TRH, GH1
7sulpiride43 28 1211.5GH1, TRH, PRL
8fenfluramine43 28 1211.5TRH, PRL, POMC
9cyproteroneacetate439.4INS, GNRH1, PRL
10spironolactone43 59 28 49 1213.4POMC, GNRH1, NPPA
11naltrexone43 28 49 1212.4GH1, GNRH1, POMC, PRL
12opiate439.3GH1, PRL, POMC, GNRH1
13apomorphine28 43 1211.3TRH, GH1, PRL
14cortisone43 2410.2INS, POMC, GH1
15clomiphene citrate439.2GH1, GNRH1, INS, PRL
16melatonin43 28 59 24 1213.2PRL, AVP, GH1, TRH
17clonidine43 49 28 1212.1POMC, TRH, PRL, GH1
18cocaine43 1210.1PRL, TRH, GNRH1, POMC
19desmopressin43 59 28 1212.1AVP, POMC, GH1, NPPA
20triiodothyronine439.1GH1, POMC, PRL, TRH
21metformin43 49 1211.0POMC, GNRH1, INS, GH1
22dhea439.0INS, POMC, PRL, GH1
23haloperidol43 49 28 2 1213.0PRL, NPPA, TRH, POMC
24bromocriptine43 28 1210.9PRL, POMC, GNRH1, GH1, TRH
25naloxone43 28 49 1211.9GNRH1, TRH, GH1, PRL, POMC
26ribonucleic acid438.8GNRH1, PRL, GH1, POMC
27metoclopramide43 49 1210.8TRH, GNRH1, PRL, GH1, NPPA
28dehydroepiandrosterone sulfate438.8POMC, GNRH1, INS, GH1, PRL
29androstenedione43 249.7GH1, INS, GNRH1, PRL, POMC
30estradiol43 24 1210.7POMC, GH1, TRH, GNRH1, PRL
31diazepam43 28 49 1211.7POMC, TRH, NPPA
32ibmx43 59 2810.7TRH, NPPA, GH1, INS
33glycerol43 24 1210.6GH1, NPPA, POMC, INS
34steroid438.6GH1, PRL, POMC, AVP, GNRH1
35progesterone43 28 59 24 1212.5POMC, GNRH1, GH1, PRL, TRH
36hydrocortisone43 2 59 1211.5PRL, TRH, POMC, INS, GH1
37dopamine43 28 24 1211.3GNRH1, GH1, TRH, POMC, PRL, NPPA
38alanine438.3GH1, POMC, AVP, GNRH1, INS
39octreotide43 59 28 1211.2GH1, POMC, PRL, GNRH1, INS, TRH
40thyroxine43 249.2POMC, INS, PRL, GH1, TRH, GNRH1
41gnrh438.2GH1, INS, GNRH1, POMC, TRH, PRL
42epinephrine43 24 1210.2GH1, NPPA, PRL, INS, POMC, GNRH1
43creatinine438.2GH1, NPPA, AVP, POMC, GNRH1, INS
44glucose438.0AVP, INS, POMC, PRL, GH1, TRH
45dexamethasone43 49 28 1210.8AVP, TRH, GH1, INS, POMC, PRL
46testosterone43 59 24 1210.7TRH, INS, PRL, NPPA, GNRH1, POMC
47estrogen437.7TRH, POMC, PRL, GH1, GNRH1, INS
48norepinephrine43 24 129.4PRL, GH1, TRH, NPPA, POMC, GNRH1
49acth437.4TRH, NPPA, PRL, POMC, GNRH1, GH1
50arginine437.3AVP, TRH, NPPA, POMC, GNRH1, INS

GO Terms for genes affiliated with Pituitary Apoplexy

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Cellular components related to Pituitary Apoplexy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:00347749.4POMC, INS
2secretory granuleGO:00301418.8TRH, POMC, AVP
3extracellular spaceGO:00056157.7AVP, INS, GNRH1, POMC, GH1, NPPA
4extracellular regionGO:00055766.9TRH, AVP, INS, GNRH1, POMC, PRL

Biological processes related to Pituitary Apoplexy according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of JAK-STAT cascadeGO:00464279.9GH1, PRL
2JAK-STAT cascade involved in growth hormone signaling pathwayGO:00603979.9GH1, PRL
3generation of precursor metabolites and energyGO:00060919.7AVP, POMC
4positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.6GH1, INS
5female pregnancyGO:00075659.5GNRH1, PRL, NPPA
6negative regulation of feeding behaviorGO:020002529.5INS, TRH
7regulation of blood pressureGO:00082179.5NPPA, POMC
8response to ethanolGO:00454719.5TRH, GNRH1, AVP
9positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.4GH1, INS
10glucose transportGO:00157589.3GH1, INS
11positive regulation of cell growthGO:00303079.2INS, AVP
12cell-cell signalingGO:00072678.4TRH, POMC, GNRH1, INS, AVP
13signal transductionGO:00071658.2AVP, AIP, GNRH1, POMC, TRH

Molecular functions related to Pituitary Apoplexy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1prolactin receptor bindingGO:00051489.6PRL, GH1
2neuropeptide hormone activityGO:00051849.3TRH, AVP
3receptor bindingGO:00051029.1NPPA, POMC, AVP
4hormone activityGO:00051797.8NPPA, GH1, PRL, POMC, GNRH1, INS

Products for genes affiliated with Pituitary Apoplexy

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Sources for Pituitary Apoplexy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet