MCID: PTT004
MIFTS: 46

Pituitary Apoplexy

Categories: Endocrine diseases, Rare diseases

Aliases & Classifications for Pituitary Apoplexy

Summaries for Pituitary Apoplexy

MalaCards based summary : Pituitary Apoplexy is related to acromegaly and adenoma, and has symptoms including diplopia, ptosis and fatigue. An important gene associated with Pituitary Apoplexy is PRL (Prolactin), and among its related pathways/superpathways are Glucocorticoid receptor regulatory network and Signaling events mediated by PTP1B. The drugs Oxytocin and Oxytocics have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and testes, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Wikipedia : 72 Pituitary apoplexy or pituitary tumor apoplexy is bleeding into or impaired blood supply of the... more...

Related Diseases for Pituitary Apoplexy

Diseases related to Pituitary Apoplexy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
id Related Disease Score Top Affiliating Genes
1 acromegaly 10.4
2 adenoma 10.4
3 pituitary adenoma 10.3
4 prostate leiomyoma 10.3 GNRH1 PRL
5 adenomatoid tumor 10.3 GNRH1 PRL
6 sifrim-hitz-weiss syndrome 10.3 AIP PRL
7 glassy cell carcinoma of the cervix 10.3 AIP PRL
8 internal hemorrhoid 10.3 GNRH1 PRL
9 pituitary adenoma, prolactin-secreting 10.2 AIP PRL
10 cerebritis 10.2
11 meningitis 10.2
12 aneurysm 10.2
13 prostatitis 10.2
14 group b strep disease in newborns 10.2 INS PRL
15 hypopituitarism 10.1
16 retroperitoneal sarcoma 10.1 GNRH1 PRL
17 diabetes insipidus 10.1
18 headache 10.1
19 cranial nerve palsy 10.1
20 prostate cancer 10.1
21 aromatase excess syndrome 10.1 GNRH1 INS
22 haverhill fever 10.1 GNRH1 PRL
23 lymphoma 10.0
24 aortic valve atresia 10.0 POMC PRL
25 olfactory nerve neoplasm 10.0 POMC PRL
26 osteoclast-like giant cell neoplasm of the pancreas 10.0 POMC PRL
27 actinobacillosis 10.0 POMC PRL
28 hypothyroidism, congenital, nongoitrous 4 10.0 POMC PRL
29 hemorrhagic fever 10.0
30 dengue hemorrhagic fever 10.0
31 thrombocytopenia 10.0
32 bacterial meningitis 10.0
33 ptosis 10.0
34 immune system organ benign neoplasm 10.0 POMC PRL
35 adrenoleukodystrophy 9.9 GNRH1 PRL
36 trabecular follicular adenocarcinoma 9.9 POMC PRL
37 bronchiectasis 9.9 POMC PRL
38 hypoglycemic coma 9.9 GNRH1 INS
39 mucositis 9.9
40 functioning pituitary adenoma 9.9
41 thyroiditis 9.9
42 adenocarcinoma 9.9
43 carotid artery occlusion 9.9
44 lymphocytic hypophysitis 9.9
45 empty sella syndrome 9.9
46 non-functioning pituitary adenoma 9.9
47 acute myeloid leukemia, susceptibility, gata2-related 9.9 POMC PRL
48 psychogenic movement 9.9 POMC PRL
49 molybdenum cofactor deficiency b 9.9 POMC PRL
50 benign peritoneal mesothelioma 9.8 GNRH1 POMC

Graphical network of the top 20 diseases related to Pituitary Apoplexy:



Diseases related to Pituitary Apoplexy

Symptoms & Phenotypes for Pituitary Apoplexy

Human phenotypes related to Pituitary Apoplexy:

56 32 (show all 43)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 diplopia 56 32 frequent (33%) Frequent (79-30%) HP:0000651
2 ptosis 56 32 occasional (7.5%) Occasional (29-5%) HP:0000508
3 fatigue 56 32 occasional (7.5%) Occasional (29-5%) HP:0012378
4 reduced visual acuity 56 32 occasional (7.5%) Occasional (29-5%) HP:0007663
5 coma 56 32 occasional (7.5%) Occasional (29-5%) HP:0001259
6 hypoglycemia 56 32 frequent (33%) Frequent (79-30%) HP:0001943
7 hyponatremia 56 32 frequent (33%) Frequent (79-30%) HP:0002902
8 photophobia 56 32 occasional (7.5%) Occasional (29-5%) HP:0000613
9 hypertension 56 32 frequent (33%) Frequent (79-30%) HP:0000822
10 confusion 56 32 very rare (1%) Very rare (<4-1%) HP:0001289
11 fever 56 32 occasional (7.5%) Occasional (29-5%) HP:0001945
12 blurred vision 56 32 occasional (7.5%) Occasional (29-5%) HP:0000622
13 growth hormone deficiency 56 32 occasional (7.5%) Occasional (29-5%) HP:0000824
14 hypergonadotropic hypogonadism 56 32 frequent (33%) Frequent (79-30%) HP:0000815
15 impotence 56 32 frequent (33%) Frequent (79-30%) HP:0000802
16 hypotension 56 32 frequent (33%) Frequent (79-30%) HP:0002615
17 oligomenorrhea 56 32 frequent (33%) Frequent (79-30%) HP:0000876
18 normochromic anemia 56 32 very rare (1%) Very rare (<4-1%) HP:0001895
19 central diabetes insipidus 56 32 very rare (1%) Very rare (<4-1%) HP:0000863
20 pallor 56 32 occasional (7.5%) Occasional (29-5%) HP:0000980
21 cranial nerve paralysis 56 32 frequent (33%) Frequent (79-30%) HP:0006824
22 pituitary adenoma 56 32 frequent (33%) Frequent (79-30%) HP:0002893
23 nausea and vomiting 56 32 frequent (33%) Frequent (79-30%) HP:0002017
24 trigeminal neuralgia 56 32 very rare (1%) Very rare (<4-1%) HP:0100661
25 galactorrhea 56 32 occasional (7.5%) Occasional (29-5%) HP:0100829
26 growth hormone excess 56 32 very rare (1%) Very rare (<4-1%) HP:0000845
27 pituitary hypothyroidism 56 32 frequent (33%) Frequent (79-30%) HP:0008245
28 mydriasis 56 32 occasional (7.5%) Occasional (29-5%) HP:0011499
29 abnormality of the cerebrospinal fluid 56 32 occasional (7.5%) Occasional (29-5%) HP:0002921
30 adrenocorticotropic hormone deficiency 56 32 frequent (33%) Frequent (79-30%) HP:0011748
31 bitemporal hemianopia 56 32 hallmark (90%) Very frequent (99-80%) HP:0030521
32 abnormal kinetic perimetry test 56 32 frequent (33%) Frequent (79-30%) HP:0030591
33 prolactin excess 56 32 occasional (7.5%) Occasional (29-5%) HP:0000870
34 prolactin deficiency 56 32 frequent (33%) Frequent (79-30%) HP:0008202
35 thunderclap headache 56 32 hallmark (90%) Very frequent (99-80%) HP:0030907
36 abnormal static automated perimetry test 56 32 frequent (33%) Frequent (79-30%) HP:0030595
37 abnormality of the caudate nucleus 56 32 very rare (1%) Very rare (<4-1%) HP:0002339
38 headache 56 Frequent (79-30%)
39 hypopituitarism 56 Occasional (29-5%)
40 somnolence 56 Very rare (<4-1%)
41 hypercortisolism 56 Very rare (<4-1%)
42 increased circulating cortisol level 32 very rare (1%) HP:0003118
43 excessive daytime somnolence 32 very rare (1%) HP:0001262

MGI Mouse Phenotypes related to Pituitary Apoplexy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.72 AIP GNRH1 INS POMC PRL
2 homeostasis/metabolism MP:0005376 9.65 POMC PRL AIP GNRH1 INS
3 integument MP:0010771 9.55 AIP GNRH1 INS POMC PRL
4 liver/biliary system MP:0005370 9.35 AIP GNRH1 INS POMC PRL
5 neoplasm MP:0002006 8.92 AIP GNRH1 POMC PRL

Drugs & Therapeutics for Pituitary Apoplexy

Drugs for Pituitary Apoplexy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxytocin Approved, Vet_approved Phase 2 50-56-6 439302 53477758
2 Oxytocics Phase 2
3
Hydrocortisone Approved, Vet_approved 50-23-7 5754 657311
4
Zinc Approved 7440-66-6 32051 23994
5
Butyric Acid Experimental 107-92-6 264
6 Anti-Inflammatory Agents
7 Cortisol succinate
8 Gastrointestinal Agents
9 glucagon
10 Glucagon-Like Peptide 1
11 Hormone Antagonists Early Phase 1
12 Hormones Early Phase 1
13 Hormones, Hormone Substitutes, and Hormone Antagonists Early Phase 1
14 Hydrocortisone 17-butyrate 21-propionate
15 Hydrocortisone acetate
16 Hydrocortisone-17-butyrate
17 Hypoglycemic Agents
18 Incretins
19 insulin
20 Insulin, Globin Zinc
21 Adrenocorticotropic Hormone Early Phase 1
22 Corticotropin-Releasing Hormone Early Phase 1
23 Growth Hormone-Releasing Hormone
24 arginine Nutraceutical

Interventional clinical trials:

(show all 14)

id Name Status NCT ID Phase Drugs
1 The Penumbra Liberty Trial: Safety and Effectiveness in the Treatment of Wide-Neck Intracranial Aneurysms Active, not recruiting NCT01636453 Phase 3
2 An Efficacy Study of Vagitocin in Postmenopausal Women With Symptoms of Vaginal Atrophy Completed NCT02497547 Phase 2 Oxytocin;Placebo
3 Pegvisomant With Glucagon Test to Assess for Adult Growth Hormone Deficiency Unknown status NCT01804413 Pegvisomant;Regular insulin
4 Evaluation of Factors in Human Brain Tumors Completed NCT00001171
5 Pelvic Pain in Women With Endometriosis Completed NCT00073801
6 Cardiac and Skeletal Muscle Energy Metabolism in Abnormal Growth Hormone States Completed NCT00461240
7 Prevalence of a High-intensity Signal of the Oculomotor Nerve on T2 MRI Sequence in Patients With Ophthalmoplegia Recruiting NCT03135574
8 Effects of Hormone Stimulation on Brain Scans for Cushing s Disease Recruiting NCT01459237 Early Phase 1 Acthrel
9 Prospective Study of Clinically Nonfunctioning Pituitary Adenomas Recruiting NCT01556230
10 Evaluation and Treatment of Neurosurgical Disorders Recruiting NCT00060541
11 Late Effects of Radiosurgery on Acromegaly Study Recruiting NCT02296216
12 Testing the Developmental Origins Hypothesis Recruiting NCT01545492
13 Prevalence of Contrast Enhancement of the Oculomotor Nerve on 3D PD T1 MRI Sequence in Patients With Ophthalmoplegia Not yet recruiting NCT03269682
14 Adult Growth Hormone Deficiency and Cardiovascular Risk Terminated NCT00720902 Growth hormone releasing hormone (GHRH) and arginine

Search NIH Clinical Center for Pituitary Apoplexy

Cochrane evidence based reviews: pituitary apoplexy

Genetic Tests for Pituitary Apoplexy

Anatomical Context for Pituitary Apoplexy

MalaCards organs/tissues related to Pituitary Apoplexy:

39
Pituitary, Brain, Testes, Prostate, Skeletal Muscle, Caudate Nucleus, Thyroid

Publications for Pituitary Apoplexy

Articles related to Pituitary Apoplexy:

(show top 50) (show all 557)
id Title Authors Year
1
Pituitary apoplexy and rivaroxaban. ( 28831662 )
2017
2
Pituitary Apoplexy Presenting as Status Migrainosus. ( 28181226 )
2017
3
Pituitary Apoplexy Mimicking Bacterial Meningitis with Intracranial Hypertension. ( 27756666 )
2017
4
Sphenoid sinus mucosal thickening in the acute phase of pituitary apoplexy. ( 28421421 )
2017
5
Endoscopic Endonasal Surgery for Pituitary Apoplexy: Evidence On a 75-Case Series From a Tertiary Care Center. ( 28669873 )
2017
6
Surgical intervention for pituitary apoplexy: an analysis of functional outcomes. ( 28946177 )
2017
7
Repeated Headache as Presentation of Pituitary Apoplexy in the Adolescent Population: Unusual Entity with Review of Literature. ( 28936095 )
2017
8
Intrasellar dermoid cyst mimicking pituitary apoplexy: A case report and review of the literature. ( 28601571 )
2017
9
Pituitary apoplexy: a rare complication of leuprolide therapy in prostate cancer treatment. ( 28710301 )
2017
10
Gestational Pituitary Apoplexy. ( 28553611 )
2017
11
Sphenoid sinus microbiota in pituitary apoplexy: a preliminary study. ( 28853001 )
2017
12
Acute Ischaemic Stroke as a Manifestation of Pituitary Apoplexy in a Young Lady. ( 28658829 )
2017
13
Management dilemmas in a rare case of pituitary apoplexy in the setting of dengue hemorrhagic fever. ( 28217383 )
2017
14
A rare case of spontaneous Cushing disease remission induced by pituitary apoplexy. ( 28251551 )
2017
15
Pituitary apoplexy presenting as a peripheral rim enhancing parasellar mass lesion with dural enhancement along the tentorium. ( 28581357 )
2017
16
Endoscopic Endonasal Surgery for Treatment of Pituitary Apoplexy: 16 Years of Experience in a Specialized Pituitary Center: Endoscopic Surgery for Pituitary Apoplexy. ( 28867316 )
2017
17
New Oral Anticoagulants and Pituitary Apoplexy. ( 28437880 )
2017
18
The impact of surgical timing on visual outcome in pituitary apoplexy: Literature review and case illustration. ( 28217395 )
2017
19
Presenting Symptoms of Pituitary Apoplexy. ( 28437813 )
2017
20
Primary immune thrombocytopenia accompanied by pituitary apoplexy. ( 27498733 )
2016
21
Management of pituitary apoplexy. ( 27006559 )
2016
22
Pituitary tuberculoma: A consideration in the differential diagnosis in a patient manifesting with pituitary apoplexy-like syndrome. ( 27516966 )
2016
23
A case of pituitary apoplexy masquerading as subarachnoid hemorrhage. ( 27014446 )
2016
24
SOCIETY FOR ENDOCRINOLOGY ENDOCRINE EMERGENCY GUIDANCE: Emergency management of pituitary apoplexy in adult patients. ( 27935817 )
2016
25
Gonadotropin-releasing hormone agonist-induced pituitary apoplexy. ( 27284452 )
2016
26
Pituitary Apoplexy After Initial Leuprolide Injection. ( 27586180 )
2016
27
Pituitary apoplexy presenting as diabetic ketoacidosis: A great simulator? Case Report. ( 26994379 )
2016
28
Pituitary apoplexy: considerations on a single center experience and review of the literature. ( 26733212 )
2016
29
Poster 329 Rehabilitation of Horizontal Diplopia due to Abducens Nerve Palsy in an Idiopathic Pituitary Apoplexy: A Case Report. ( 27673084 )
2016
30
Pituitary apoplexy complicated by vasospasm and bilateral cerebral infarction. ( 27329099 )
2016
31
A pediatric case of pituitary macroadenoma presenting with pituitary apoplexy and cranial nerve involvement: case report. ( 27738402 )
2016
32
Third, Fourth, and Sixth Cranial Nerve Palsies in Pituitary Apoplexy. ( 27436207 )
2016
33
Pituitary apoplexy masquerading as functional decline in an older person. ( 27810852 )
2016
34
Multidisciplinary Management of Pituitary Apoplexy. ( 28074095 )
2016
35
Pituitary Apoplexy Associated with Carotid Compression and a Large Ischemic Penumbra. ( 27319311 )
2016
36
Pituitary apoplexy causing clival and spinal haematoma. ( 26743947 )
2016
37
Spontaneous pituitary apoplexy during the second trimester of pregnancy, with sensory loss. ( 26884071 )
2016
38
Pituitary apoplexy as presentation of atypical teratoid/rhabdoid tumor in an adult. ( 27349334 )
2016
39
Pituitary apoplexy causing spontaneous remission of acromegaly following long-acting octreotide therapy: a rare drug side effect or just a coincidence. ( 27123308 )
2016
40
Pituitary Apoplexy- Bespoke Patient Management Allows Good Clinical Outcome. ( 27038242 )
2016
41
Prolactinoma and pregnancy - a series of cases including pituitary apoplexy. ( 27866462 )
2016
42
PITUITARY APOPLEXY DUE TO DAIGNOSTIC TEST IN CUSHING'S DISEASE PATIENT. ( 27593808 )
2016
43
Surgical versus non-surgical treatment for pituitary apoplexy: A systematic review and meta-analysis. ( 27772771 )
2016
44
A primer on pituitary injury for the obstetrician gynecologist: Simmonds disease, Sheehan's syndrome, Traumatic injury, Dahan' s syndrome, Pituitary Apoplexy and Lymphocytic Hypophysitis. ( 27405776 )
2016
45
Pituitary apoplexy: pathophysiology, diagnosis and management. ( 26154095 )
2015
46
Recurrent pituitary apoplexy due to two successive neoplasms presenting with ocular paresis and epistaxis. ( 25755879 )
2015
47
Pituitary apoplexy induced by triptorelin in patient with prostate cancer. ( 26184059 )
2015
48
Rapid pituitary apoplexy regression: what is the time course of clot resolution? ( 25861507 )
2015
49
Incidence of Pituitary Apoplexy and Its Risk Factors in Chinese People: A Database Study of Patients with Pituitary Adenoma. ( 26407083 )
2015
50
Pituitary apoplexy. ( 25732655 )
2015

Variations for Pituitary Apoplexy

Expression for Pituitary Apoplexy

Search GEO for disease gene expression data for Pituitary Apoplexy.

Pathways for Pituitary Apoplexy

Pathways related to Pituitary Apoplexy according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.87 POMC PRL
2 10.32 INS PRL

GO Terms for Pituitary Apoplexy

Cellular components related to Pituitary Apoplexy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 secretory granule lumen GO:0034774 8.96 INS POMC
2 endosome lumen GO:0031904 8.62 INS PRL

Biological processes related to Pituitary Apoplexy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 female pregnancy GO:0007565 8.96 GNRH1 PRL
2 glucose homeostasis GO:0042593 8.85 INS
3 cell-cell signaling GO:0007267 8.8 GNRH1 INS POMC

Molecular functions related to Pituitary Apoplexy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.92 GNRH1 INS POMC PRL

Sources for Pituitary Apoplexy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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