MCID: PTT008
MIFTS: 51

Pituitary Carcinoma

Categories: Rare diseases, Cancer diseases, Endocrine diseases

Aliases & Classifications for Pituitary Carcinoma

MalaCards integrated aliases for Pituitary Carcinoma:

Name: Pituitary Carcinoma 12 49 55 14 69
Malignant Neoplasm of Pituitary Gland 69
Carcinoma of the Pituitary Gland 12
Pituitary Cancer 49

Characteristics:

Orphanet epidemiological data:

55
pituitary carcinoma
Prevalence: <1/1000000 (Europe),1-9/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

Disease Ontology 12 DOID:4916
MeSH 41 D010911
NCIt 46 C4536
SNOMED-CT 64 128665000 254955001
Orphanet 55 ORPHA300385
UMLS via Orphanet 70 C0346300
ICD10 via Orphanet 33 C75.1
ICD10 32 C75.1

Summaries for Pituitary Carcinoma

MalaCards based summary : Pituitary Carcinoma, also known as malignant neoplasm of pituitary gland, is related to hormone producing pituitary cancer and functioning pituitary adenoma, and has symptoms including prolactin excess, headache and increased circulating acth level. An important gene associated with Pituitary Carcinoma is POMC (Proopiomelanocortin), and among its related pathways/superpathways are Peptide ligand-binding receptors and Salivary secretion. The drugs nivolumab and Lapatinib have been mentioned in the context of this disorder. Affiliated tissues include pituitary, spinal cord and liver, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Pituitary Carcinoma

Diseases related to Pituitary Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 hormone producing pituitary cancer 32.4 GNAS SST SSTR2
2 functioning pituitary adenoma 29.8 POMC SST
3 pituitary tumors 29.5 GNAS POMC SST
4 adrenal gland hyperfunction 29.3 CRH POMC SST
5 adenoma 29.1 GNAS POMC SST SSTR2
6 pituitary adenoma, prolactin-secreting 28.7 GNAS POMC SST SSTR2
7 acromegaly 28.6 GNAS POMC SST SSTR2
8 pituitary adenoma 28.4 CRH GNAS POMC SST SSTR2
9 prolactin producing pituitary tumor 10.9
10 bronchus adenoma 10.4 POMC SST
11 bronchial adenomas/carcinoids childhood 10.4 POMC SST
12 acidophil adenoma 10.4 POMC SST
13 pituitary infarct 10.4 POMC SST
14 chiasmal syndrome 10.3 POMC SST
15 hyperpituitarism 10.3 POMC SST
16 acute thyroiditis 10.3 CHGA POMC
17 gastrointestinal neuroendocrine benign tumor 10.3 CHGA SST
18 gastric neuroendocrine neoplasm 10.3 CHGA SST
19 adenoma of the pancreas 10.3 CHGA SST
20 syndrome of inappropriate antidiuretic hormone 10.3 CHGA POMC
21 endocrine pancreas disease 10.3 POMC SST
22 glucagonoma 10.3 CHGA SST
23 hyperinsulinemic hypoglycemia, familial, 2 10.3 CHGA SST
24 cervix small cell carcinoma 10.3 CHGA POMC
25 vipoma 10.3 CHGA SST
26 pancreatoblastoma 10.3 CHGA SST
27 hypothalamic disease 10.3 CRH POMC
28 somatostatinoma 10.3 CHGA SST
29 pancreas disease 10.3 POMC SST
30 acth deficiency, isolated 10.3 CRH POMC
31 carcinoid syndrome 10.3 CHGA SST
32 sheehan syndrome 10.3 CRH POMC
33 hypoadrenalism 10.3 CRH POMC
34 zollinger-ellison syndrome 10.3 CHGA SST
35 organ system benign neoplasm 10.2 POMC SST
36 fasting hypoglycemia 10.2 CRH POMC
37 type c thymoma 10.2 SST SSTR2
38 gastrinoma 10.2 CHGA SST
39 adrenal cortical hypofunction 10.2 CRH POMC
40 pancreatic endocrine carcinoma 10.2 SST SSTR2
41 pancreatic gastrinoma 10.2 CHGA SST
42 islet cell tumor 10.2 CHGA SST
43 withdrawal disorder 10.2 CRH POMC
44 persistent fetal circulation syndrome 10.2 CRH POMC
45 serotonin syndrome 10.2 CHGA SST
46 premenstrual tension 10.2 CRH POMC
47 hypoadrenocorticism, familial 10.2 CRH POMC
48 hyperprolactinemia 10.2 POMC SST
49 mental depression 10.2 CRH POMC
50 olfactory neuroblastoma 10.2 CHGA SSTR2

Graphical network of the top 20 diseases related to Pituitary Carcinoma:



Diseases related to Pituitary Carcinoma

Symptoms & Phenotypes for Pituitary Carcinoma

Human phenotypes related to Pituitary Carcinoma:

55 31 (show all 24)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 pituitary carcinoma 55 31 obligate (100%) Obligate (100%) HP:0011763
2 prolactin excess 55 31 hallmark (90%) Very frequent (99-80%) HP:0000870
3 headache 55 31 hallmark (90%) Very frequent (99-80%) HP:0002315
4 increased circulating acth level 55 31 hallmark (90%) Very frequent (99-80%) HP:0003154
5 pituitary prolactin cell adenoma 55 31 hallmark (90%) Very frequent (99-80%) HP:0006767
6 pituitary corticotropic cell adenoma 55 31 hallmark (90%) Very frequent (99-80%) HP:0008291
7 malignant neoplasm of the central nervous system 55 31 hallmark (90%) Very frequent (99-80%) HP:0100836
8 progressive visual field defects 55 31 frequent (33%) Frequent (79-30%) HP:0007987
9 enlarged pituitary gland 55 31 frequent (33%) Frequent (79-30%) HP:0012505
10 hypopituitarism 55 31 frequent (33%) Frequent (79-30%) HP:0040075
11 hearing impairment 55 31 occasional (7.5%) Occasional (29-5%) HP:0000365
12 growth hormone excess 55 31 occasional (7.5%) Occasional (29-5%) HP:0000845
13 ataxia 55 31 occasional (7.5%) Occasional (29-5%) HP:0001251
14 pituitary growth hormone cell adenoma 55 31 occasional (7.5%) Occasional (29-5%) HP:0011760
15 spinal cord lesion 55 31 occasional (7.5%) Occasional (29-5%) HP:0100561
16 diabetes insipidus 55 31 very rare (1%) Very rare (<4-1%) HP:0000873
17 pituitary gonadotropic cell adenoma 55 31 very rare (1%) Very rare (<4-1%) HP:0011759
18 pituitary thyrotropic cell adenoma 55 31 very rare (1%) Very rare (<4-1%) HP:0011762
19 mildly reduced visual acuity 55 Frequent (79-30%)
20 hemianopsia 55 Frequent (79-30%)
21 hyperpituitarism 55 Occasional (29-5%)
22 abnormality of central motor function 55 Occasional (29-5%)
23 reduced visual acuity 31 frequent (33%) HP:0007663
24 hemianopia 31 frequent (33%) HP:0012377

MGI Mouse Phenotypes related to Pituitary Carcinoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.85 THRB CRH GNAS POMC SST SSTR2
2 growth/size/body region MP:0005378 9.73 CHGA THRB CRH GNAS POMC SST
3 endocrine/exocrine gland MP:0005379 9.72 CHGA THRB CRH GNAS POMC
4 homeostasis/metabolism MP:0005376 9.7 THRB CRH GNAS POMC SST SSTR2
5 nervous system MP:0003631 9.43 THRB CRH GNAS POMC SST SSTR2
6 no phenotypic analysis MP:0003012 9.1 CRH GNAS POMC SST CHGA THRB

Drugs & Therapeutics for Pituitary Carcinoma

Drugs for Pituitary Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2
Lapatinib Approved March 2007, Investigational Phase 2 231277-92-2, 388082-78-8 208908 9941095
3 Protein Kinase Inhibitors Phase 2
4 Antibodies Phase 2
5 Antibodies, Monoclonal Phase 2
6 Immunoglobulins Phase 2
7
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
8
Dactinomycin Approved, Investigational 50-76-0 457193 2019
9
Doxorubicin Approved, Investigational 23214-92-8 31703
10
Ifosfamide Approved 3778-73-2 3690
11
Vincristine Approved, Investigational 2068-78-2, 57-22-7 5978
12
Doxil Approved June 1999 31703
13 Isophosphamide mustard 0

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Targeted Therapy With Lapatinib in Patients With Recurrent Pituitary Tumors Resistant to Standard Therapy Recruiting NCT00939523 Phase 2 Lapatinib
2 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
3 Identification of GENEtic Markers of Aggressiveness and Malignancy by Array Comparative Genomic Hybrization Analysis (CGH) Completed NCT01903967
4 PITUItary Carcinoma or Aggressive Tumors REgistry -Lyon Recruiting NCT02854228
5 International PPB Registry for PPB, DICER1 and Associated Conditions Recruiting NCT03382158

Search NIH Clinical Center for Pituitary Carcinoma

Genetic Tests for Pituitary Carcinoma

Anatomical Context for Pituitary Carcinoma

MalaCards organs/tissues related to Pituitary Carcinoma:

38
Pituitary, Spinal Cord, Liver, Lymph Node, Thyroid, Lung, Bone

Publications for Pituitary Carcinoma

Articles related to Pituitary Carcinoma:

(show top 50) (show all 71)
# Title Authors Year
1
Malignant transformation in non-functioning pituitary adenomas (pituitary carcinoma). ( 29299820 )
2018
2
Neuro-Ophthalmic Manifestations of Pituitary Carcinoma. ( 29315125 )
2018
3
Corticotrophic pituitary carcinoma with cervical metastases: case series and literature review. ( 29404894 )
2018
4
Successful treatment of pituitary carcinoma with concurrent radiation, temozolomide, and bevacizumab after resection. ( 28291643 )
2017
5
Cytomorphology of metastatic pituitary carcinoma to the bone. ( 28267302 )
2017
6
Pituitary Carcinoma in a Patient with an SDHB Mutation. ( 28284009 )
2017
7
Successful treatment of leptomeningeally metastasised pituitary carcinoma with temozolomide. ( 29256415 )
2017
8
Temozolomide treatment can improve overall survival in aggressive pituitary tumors and pituitary carcinomas. ( 28432119 )
2017
9
Meningeal dissemination of a pituitary carcinoma to the cauda equina in a dog. ( 28761190 )
2017
10
Corticotroph pituitary carcinoma in a patient with Lynch syndrome (LS) and pituitary tumors in a nationwide LS cohort. ( 28938458 )
2017
11
Significant response of pituitary carcinoma to carboplatin, leucovorin and fluorouracil chemotherapy: a pediatric case report and review of the literature. ( 28667593 )
2017
12
A Case of Pituitary Carcinoma Initially Diagnosed as an Ectopic Growth Hormone Producing Pituitary Adenoma with a High Ki-67 Labeling Index. ( 28586933 )
2017
13
Seeding of a Pituitary Adenoma or Atypical Pituitary Carcinoma? ( 28589060 )
2017
14
Metastatic Pituitary Carcinoma to Cervical Lymph Node: Diagnosis by Fine Needle Aspiration and Review of the Literature. ( 28399532 )
2017
15
Case report: ACTH-secreting pituitary carcinoma metastatic to the liver in a patient with a history of atypical pituitary adenoma and Cushing's disease. ( 28420444 )
2017
16
Failure of a second temozolomide cycle in a patient with a prolactin-secreting pituitary carcinoma. ( 29137963 )
2017
17
Pituitary carcinoma: A case report and discussion of potential value of combined use of Ga-68 DOTATATE and F-18 FDG PET/CT scan to better choose therapy. ( 28840066 )
2017
18
Genetic aspects of pituitary carcinoma: A systematic review. ( 27893664 )
2016
19
Secreting Follicle-Stimulating Hormone Pituitary Carcinoma with Cervical Metastasis. ( 27449685 )
2016
20
Radiotherapy with concurrent temozolomide for the management of extraneural metastases in pituitary carcinoma. ( 27106209 )
2016
21
Response of silent corticotroph pituitary carcinoma to chemotherapy: case report. ( 27150544 )
2016
22
Temozolomide therapy: Focus on patients with pituitary carcinoma. ( 27365946 )
2016
23
Prolactin-Secreting Pituitary Carcinoma with Dural Metastasis: Diagnosis, Treatment, and Future Directions. ( 27157283 )
2016
24
Diagnosis and Treatment of Pituitary Carcinoma. ( 26564466 )
2015
25
Progression of an Invasive ACTH Pituitary Macroadenoma with Cushing's Disease to Pituitary Carcinoma. ( 26366311 )
2015
26
MicroRNA involvement in a metastatic non-functioning pituitary carcinoma. ( 25862551 )
2015
27
Long-term outcome and MGMT as a predictive marker in 24 patients with atypical pituitary adenomas and pituitary carcinomas given treatment with temozolomide. ( 25646794 )
2015
28
Pituitary carcinoma with intraspinal metastasis: report of two cases and review of the literature. ( 26464743 )
2015
29
Drop metastasis of adrenocorticotropic hormone-producing pituitary carcinoma to the cauda equina. ( 25346823 )
2014
30
A case report of feline pituitary carcinoma with hypercortisolism. ( 24025433 )
2014
31
Multiple cerebral hemorrhagic foci from metastases during temozolomide treatment in a patient with corticotroph pituitary carcinoma. ( 24823463 )
2014
32
Invasive adenoma and pituitary carcinoma: a SEER database analysis. ( 24526366 )
2014
33
Pituitary carcinoma with fourth ventricle metastasis: treatment by excision and Gamma-knife radiosurgery. ( 24272034 )
2014
34
Pituitary carcinoma with endolymphatic sac metastasis. ( 23645293 )
2014
35
The Use of 68Ga DOTATATE PET/CT for Diagnostic Assessment and Monitoring of 177Lu DOTATATE Therapy in Pituitary Carcinoma. ( 25275413 )
2014
36
Lesions of the petrous ridge: metastatic pituitary carcinoma with discussion of differential diagnosis. ( 24622018 )
2014
37
Improvement in Diagnosis of Metastatic Pituitary Carcinoma by 68Ga DOTATATE PET/CT. ( 24873798 )
2014
38
Pituitary carcinoma: a devastating disease in need of an earlier diagnosis and of effective therapies. ( 22120355 )
2013
39
Long-term follow-up of growth hormone-producing pituitary carcinoma with multiple spinal metastases following multiple surgeries: case report. ( 24077272 )
2013
40
Chemotherapy-induced regression of an adrenocorticotropin-secreting pituitary carcinoma accompanied by secondary adrenal insufficiency. ( 24455332 )
2013
41
The significance of MEN1 mutations in pituitary carcinomas. ( 23905891 )
2013
42
Pituitary carcinoma in situ. ( 23425649 )
2013
43
DNA mismatch repair protein (MSH6) correlated with the responses of atypical pituitary adenomas and pituitary carcinomas to temozolomide: the national cooperative study by the Japan Society for Hypothalamic and Pituitary Tumors. ( 23365123 )
2013
44
Tumor-to-tumor metastasis from pituitary carcinoma to radiation-induced meningioma. ( 22989053 )
2013
45
Molecular status of pituitary carcinoma and atypical adenoma that contributes the effectiveness of temozolomide. ( 23955641 )
2013
46
Pituitary carcinoma recurrent to the lumbar intradural extramedullary space: case report. ( 22333938 )
2012
47
Long-term control of a MEN1 prolactin secreting pituitary carcinoma after temozolomide treatment. ( 22520146 )
2012
48
Metastatic pituitary carcinoma in a patient with acromegaly: a case report. ( 23009369 )
2012
49
A case of nonfunctioning pituitary carcinoma that responded to temozolomide treatment. ( 23091742 )
2012
50
What causes a prolactinoma to be aggressive or to become a pituitary carcinoma? ( 23422771 )
2012

Variations for Pituitary Carcinoma

Expression for Pituitary Carcinoma

Search GEO for disease gene expression data for Pituitary Carcinoma.

GO Terms for Pituitary Carcinoma

Cellular components related to Pituitary Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 CHGA CRH GNAS POMC SST

Biological processes related to Pituitary Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.77 CRH GNAS POMC SSTR2 THRB
2 response to drug GO:0042493 9.5 CRH GNAS SST
3 response to nutrient GO:0007584 9.48 SST SSTR2
4 regulation of blood pressure GO:0008217 9.46 CHGA POMC
5 digestion GO:0007586 9.43 SST SSTR2
6 cell-cell signaling GO:0007267 9.43 POMC SST SSTR2
7 positive regulation of cAMP biosynthetic process GO:0030819 9.4 CRH GNAS
8 G-protein coupled receptor signaling pathway GO:0007186 9.35 CRH GNAS POMC SST SSTR2
9 positive regulation of cAMP-mediated signaling GO:0043950 9.16 CRH GNAS
10 hormone-mediated apoptotic signaling pathway GO:0008628 8.62 CRH SST

Molecular functions related to Pituitary Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 9.16 CRH POMC
2 hormone activity GO:0005179 9.13 CRH POMC SST
3 corticotropin-releasing hormone receptor 1 binding GO:0051430 8.62 CRH GNAS

Sources for Pituitary Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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