MCID: PTT008
MIFTS: 46

Pituitary Carcinoma

Categories: Rare diseases, Cancer diseases, Endocrine diseases

Aliases & Classifications for Pituitary Carcinoma

MalaCards integrated aliases for Pituitary Carcinoma:

Name: Pituitary Carcinoma 12 50 56 14 69
Malignant Neoplasm of Pituitary Gland 69
Carcinoma of the Pituitary Gland 12
Pituitary Cancer 50

Characteristics:

Orphanet epidemiological data:

56
pituitary carcinoma
Prevalence: <1/1000000 (Europe),1-9/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:



Summaries for Pituitary Carcinoma

MalaCards based summary : Pituitary Carcinoma, also known as malignant neoplasm of pituitary gland, is related to prolactin producing pituitary tumor and hormone producing pituitary cancer, and has symptoms including prolactin excess, headache and increased circulating acth level. An important gene associated with Pituitary Carcinoma is POMC (Proopiomelanocortin), and among its related pathways/superpathways are Peptide ligand-binding receptors and Salivary secretion. The drugs nivolumab and Lapatinib have been mentioned in the context of this disorder. Affiliated tissues include pituitary, spinal cord and liver, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Pituitary Carcinoma

Diseases related to Pituitary Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)
id Related Disease Score Top Affiliating Genes
1 prolactin producing pituitary tumor 32.0 POMC SST
2 hormone producing pituitary cancer 11.8
3 functioning pituitary adenoma 10.6 POMC SST
4 african histoplasmosis 10.5 POMC SST
5 lymphoepithelioma-like carcinoma 10.5 POMC SST
6 protein s deficiency 10.5 POMC SST
7 strabismus 10.5 POMC SST
8 parietal lobe neoplasm 10.5 CHGA POMC
9 primary syphilis 10.5 CHGA SST
10 bone giant cell sarcoma 10.5 CHGA SST
11 synovial chondromatosis 10.5 CHGA POMC
12 glutamate decarboxylase deficiency 10.5 CHGA SST
13 neurogenic arthropathy 10.4 POMC SST
14 spinal muscular atrophy 10.4 CHGA SST
15 internal auditory canal lipoma 10.4 CHGA POMC
16 gastric gastrinoma 10.4 CHGA SST
17 rete ovarii cystadenofibroma 10.4 CHGA SST
18 chondroma 10.4 POMC SST
19 intermittent squint 10.4 CRH POMC
20 ulcerative blepharitis 10.4 CRH POMC
21 hypodermyasis 10.4 CRH POMC
22 carcinoma of unknown primary site, childhood 10.4 CHGA SST
23 primary progressive multiple sclerosis 10.4 CHGA SST
24 febrile infection-related epilepsy syndrome 10.4 CRH POMC
25 dressler's syndrome 10.4 CRH POMC
26 oral leukoedema 10.4 SST SSTR2
27 neuritis 10.4 SST SSTR2
28 lung giant cell carcinoma 10.4 CHGA SST
29 volkmann contracture 10.4 CHGA SST
30 kartagener syndrome 10.4 CHGA SST
31 autoimmune disease of central nervous system 10.4 CRH POMC
32 alpha-methylacyl-coa racemase deficiency 10.4 POMC SST
33 traumatic glaucoma 10.4 CRH POMC
34 acquired aneurysmal subarachnoid hemorrhage 10.4 CHGA SST
35 uterine corpus adenocarcinofibroma 10.4 CRH POMC
36 acute myeloid leukemia, susceptibility, gata2-related 10.3 CRH POMC
37 seminoma 10.3 SST SSTR2
38 keratosis 10.3 CRH POMC
39 posterior uveal melanoma 10.3 CRH POMC
40 anal canal adenocarcinoma 10.3 CHGA SSTR2
41 capillary lymphangioma 10.3 CRH POMC
42 adrenal cortical adenocarcinoma 10.3 CRH POMC
43 extrinsic cardiomyopathy 10.3 CHGA SST
44 hypertensive encephalopathy 10.2 CRH POMC
45 acute gonococcal salpingitis 10.2 CRH POMC
46 fibrolamellar carcinoma 10.2 POMC THRB
47 opitz-gbbb syndrome 10.2 CHGA SST
48 hypermobility syndrome 10.2 CRH POMC
49 hallucinogen dependence 10.1 CRH POMC
50 myositis fibrosa 10.1 CHGA CRH

Graphical network of the top 20 diseases related to Pituitary Carcinoma:



Diseases related to Pituitary Carcinoma

Symptoms & Phenotypes for Pituitary Carcinoma

Human phenotypes related to Pituitary Carcinoma:

56 32 (show all 24)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 pituitary carcinoma 56 32 obligate (100%) Obligate (100%) HP:0011763
2 prolactin excess 56 32 hallmark (90%) Very frequent (99-80%) HP:0000870
3 headache 56 32 hallmark (90%) Very frequent (99-80%) HP:0002315
4 increased circulating acth level 56 32 hallmark (90%) Very frequent (99-80%) HP:0003154
5 pituitary prolactin cell adenoma 56 32 hallmark (90%) Very frequent (99-80%) HP:0006767
6 pituitary corticotropic cell adenoma 56 32 hallmark (90%) Very frequent (99-80%) HP:0008291
7 malignant neoplasm of the central nervous system 56 32 hallmark (90%) Very frequent (99-80%) HP:0100836
8 progressive visual field defects 56 32 frequent (33%) Frequent (79-30%) HP:0007987
9 enlarged pituitary gland 56 32 frequent (33%) Frequent (79-30%) HP:0012505
10 hypopituitarism 56 32 frequent (33%) Frequent (79-30%) HP:0040075
11 hearing impairment 56 32 occasional (7.5%) Occasional (29-5%) HP:0000365
12 growth hormone excess 56 32 occasional (7.5%) Occasional (29-5%) HP:0000845
13 ataxia 56 32 occasional (7.5%) Occasional (29-5%) HP:0001251
14 pituitary growth hormone cell adenoma 56 32 occasional (7.5%) Occasional (29-5%) HP:0011760
15 spinal cord lesion 56 32 occasional (7.5%) Occasional (29-5%) HP:0100561
16 diabetes insipidus 56 32 very rare (1%) Very rare (<4-1%) HP:0000873
17 pituitary gonadotropic cell adenoma 56 32 very rare (1%) Very rare (<4-1%) HP:0011759
18 pituitary thyrotropic cell adenoma 56 32 very rare (1%) Very rare (<4-1%) HP:0011762
19 mildly reduced visual acuity 56 Frequent (79-30%)
20 hemianopsia 56 Frequent (79-30%)
21 hyperpituitarism 56 Occasional (29-5%)
22 abnormality of central motor function 56 Occasional (29-5%)
23 reduced visual acuity 32 frequent (33%) HP:0007663
24 hemianopia 32 frequent (33%) HP:0012377

MGI Mouse Phenotypes related to Pituitary Carcinoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.85 CRH GNAS POMC SST SSTR2 THRB
2 growth/size/body region MP:0005378 9.73 CHGA CRH GNAS POMC SST THRB
3 endocrine/exocrine gland MP:0005379 9.72 CHGA CRH GNAS POMC THRB
4 homeostasis/metabolism MP:0005376 9.7 CHGA CRH GNAS POMC SST SSTR2
5 nervous system MP:0003631 9.43 CRH GNAS POMC SST SSTR2 THRB
6 no phenotypic analysis MP:0003012 9.02 CRH GNAS POMC SST THRB

Drugs & Therapeutics for Pituitary Carcinoma

Drugs for Pituitary Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2
Lapatinib Approved March 2007, Investigational Phase 2 231277-92-2, 388082-78-8 208908 9941095
3 Protein Kinase Inhibitors Phase 2
4 Antibodies Phase 2
5 Antibodies, Monoclonal Phase 2
6 Immunoglobulins Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Targeted Therapy With Lapatinib in Patients With Recurrent Pituitary Tumors Resistant to Standard Therapy Recruiting NCT00939523 Phase 2 Lapatinib
2 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
3 Antineoplaston Therapy in Treating Patients With Neuroendocrine Tumor That Is Metastatic or Unlikely to Respond to Surgery or Radiation Therapy Withdrawn NCT00003514 Phase 2 antineoplaston A10;antineoplaston AS2-1
4 Identification of GENEtic Markers of Aggressiveness and Malignancy by Array Comparative Genomic Hybrization Analysis (CGH) Completed NCT01903967
5 PITUItary Carcinoma or Aggressive Tumors REgistry -Lyon Recruiting NCT02854228
6 Nasopharyngeal Carcinoma Post IMRT Active, not recruiting NCT02597426

Search NIH Clinical Center for Pituitary Carcinoma

Genetic Tests for Pituitary Carcinoma

Anatomical Context for Pituitary Carcinoma

MalaCards organs/tissues related to Pituitary Carcinoma:

39
Pituitary, Spinal Cord, Liver, Lymph Node, Thyroid, Lung, Bone

Publications for Pituitary Carcinoma

Articles related to Pituitary Carcinoma:

(show top 50) (show all 66)
id Title Authors Year
1
Meningeal dissemination of a pituitary carcinoma to the cauda equina in a dog. ( 28761190 )
2017
2
A Case of Pituitary Carcinoma Initially Diagnosed as an Ectopic Growth Hormone Producing Pituitary Adenoma with a High Ki-67 Labeling Index. ( 28586933 )
2017
3
Case report: ACTH-secreting pituitary carcinoma metastatic to the liver in a patient with a history of atypical pituitary adenoma and Cushing's disease. ( 28420444 )
2017
4
Corticotroph pituitary carcinoma in a patient with Lynch syndrome (LS) and pituitary tumors in a nationwide LS cohort. ( 28938458 )
2017
5
Seeding of a Pituitary Adenoma or Atypical Pituitary Carcinoma? ( 28589060 )
2017
6
Successful treatment of pituitary carcinoma with concurrent radiation, temozolomide, and bevacizumab after resection. ( 28291643 )
2017
7
Pituitary Carcinoma in a Patient with an SDHB Mutation. ( 28284009 )
2017
8
Cytomorphology of metastatic pituitary carcinoma to the bone. ( 28267302 )
2017
9
Metastatic Pituitary Carcinoma to Cervical Lymph Node: Diagnosis by Fine Needle Aspiration and Review of the Literature. ( 28399532 )
2017
10
Temozolomide treatment can improve overall survival in aggressive pituitary tumors and pituitary carcinomas. ( 28432119 )
2017
11
Significant response of pituitary carcinoma to carboplatin, leucovorin and fluorouracil chemotherapy: a pediatric case report and review of the literature. ( 28667593 )
2017
12
Pituitary carcinoma: A case report and discussion of potential value of combined use of Ga-68 DOTATATE and F-18 FDG PET/CT scan to better choose therapy. ( 28840066 )
2017
13
Genetic aspects of pituitary carcinoma: A systematic review. ( 27893664 )
2016
14
Response of silent corticotroph pituitary carcinoma to chemotherapy: case report. ( 27150544 )
2016
15
Radiotherapy with concurrent temozolomide for the management of extraneural metastases in pituitary carcinoma. ( 27106209 )
2016
16
Temozolomide therapy: Focus on patients with pituitary carcinoma. ( 27365946 )
2016
17
Prolactin-Secreting Pituitary Carcinoma with Dural Metastasis: Diagnosis, Treatment, and Future Directions. ( 27157283 )
2016
18
Secreting Follicle-Stimulating Hormone Pituitary Carcinoma with Cervical Metastasis. ( 27449685 )
2016
19
Pituitary carcinoma with intraspinal metastasis: report of two cases and review of the literature. ( 26464743 )
2015
20
MicroRNA involvement in a metastatic non-functioning pituitary carcinoma. ( 25862551 )
2015
21
Diagnosis and Treatment of Pituitary Carcinoma. ( 26564466 )
2015
22
Progression of an Invasive ACTH Pituitary Macroadenoma with Cushing's Disease to Pituitary Carcinoma. ( 26366311 )
2015
23
Long-term outcome and MGMT as a predictive marker in 24 patients with atypical pituitary adenomas and pituitary carcinomas given treatment with temozolomide. ( 25646794 )
2015
24
A case report of feline pituitary carcinoma with hypercortisolism. ( 24025433 )
2014
25
Pituitary carcinoma with fourth ventricle metastasis: treatment by excision and Gamma-knife radiosurgery. ( 24272034 )
2014
26
Drop metastasis of adrenocorticotropic hormone-producing pituitary carcinoma to the cauda equina. ( 25346823 )
2014
27
The Use of 68Ga DOTATATE PET/CT for Diagnostic Assessment and Monitoring of 177Lu DOTATATE Therapy in Pituitary Carcinoma. ( 25275413 )
2014
28
Pituitary carcinoma with endolymphatic sac metastasis. ( 23645293 )
2014
29
Invasive adenoma and pituitary carcinoma: a SEER database analysis. ( 24526366 )
2014
30
Improvement in Diagnosis of Metastatic Pituitary Carcinoma by 68Ga DOTATATE PET/CT. ( 24873798 )
2014
31
Lesions of the petrous ridge: metastatic pituitary carcinoma with discussion of differential diagnosis. ( 24622018 )
2014
32
Multiple cerebral hemorrhagic foci from metastases during temozolomide treatment in a patient with corticotroph pituitary carcinoma. ( 24823463 )
2014
33
Pituitary carcinoma in situ. ( 23425649 )
2013
34
Molecular status of pituitary carcinoma and atypical adenoma that contributes the effectiveness of temozolomide. ( 23955641 )
2013
35
Long-term follow-up of growth hormone-producing pituitary carcinoma with multiple spinal metastases following multiple surgeries: case report. ( 24077272 )
2013
36
DNA mismatch repair protein (MSH6) correlated with the responses of atypical pituitary adenomas and pituitary carcinomas to temozolomide: the national cooperative study by the Japan Society for Hypothalamic and Pituitary Tumors. ( 23365123 )
2013
37
Tumor-to-tumor metastasis from pituitary carcinoma to radiation-induced meningioma. ( 22989053 )
2013
38
The significance of MEN1 mutations in pituitary carcinomas. ( 23905891 )
2013
39
Chemotherapy-induced regression of an adrenocorticotropin-secreting pituitary carcinoma accompanied by secondary adrenal insufficiency. ( 24455332 )
2013
40
Pituitary carcinoma: a devastating disease in need of an earlier diagnosis and of effective therapies. ( 22120355 )
2013
41
What causes a prolactinoma to be aggressive or to become a pituitary carcinoma? ( 23422771 )
2012
42
A case of nonfunctioning pituitary carcinoma that responded to temozolomide treatment. ( 23091742 )
2012
43
Pituitary carcinoma recurrent to the lumbar intradural extramedullary space: case report. ( 22333938 )
2012
44
Metastatic pituitary carcinoma in a patient with acromegaly: a case report. ( 23009369 )
2012
45
Long-term control of a MEN1 prolactin secreting pituitary carcinoma after temozolomide treatment. ( 22520146 )
2012
46
A mechanism of acquiring temozolomide resistance during transformation of atypical prolactinoma into prolactin-producing pituitary carcinoma: case report. ( 21389894 )
2011
47
MicroRNA expression in ACTH-producing pituitary tumors: up-regulation of microRNA-122 and -493 in pituitary carcinomas. ( 20960104 )
2010
48
Temozolomide treatment in aggressive pituitary tumors and pituitary carcinomas: a French multicenter experience. ( 20660056 )
2010
49
Multiple endocrine neoplasia type 1-associated thyrotropin-producing pituitary carcinoma: report of a probable de novo example. ( 18755492 )
2009
50
[Pituitary carcinomas and aggressive adenomas: an overview and new therapeutic options]. ( 19878763 )
2009

Variations for Pituitary Carcinoma

Expression for Pituitary Carcinoma

Search GEO for disease gene expression data for Pituitary Carcinoma.

GO Terms for Pituitary Carcinoma

Cellular components related to Pituitary Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 CHGA CRH GNAS POMC SST

Biological processes related to Pituitary Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.65 CRH GNAS POMC SSTR2 THRB
2 response to drug GO:0042493 9.5 CRH GNAS SST
3 regulation of blood pressure GO:0008217 9.4 CHGA POMC
4 digestion GO:0007586 9.37 SST SSTR2
5 cell-cell signaling GO:0007267 9.33 POMC SST SSTR2
6 positive regulation of cAMP biosynthetic process GO:0030819 8.96 CRH GNAS
7 hormone-mediated apoptotic signaling pathway GO:0008628 8.62 CRH SST

Molecular functions related to Pituitary Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.13 CRH POMC SST
2 neuropeptide hormone activity GO:0005184 8.85 CRH
3 corticotropin-releasing hormone receptor 1 binding GO:0051430 8.62 CRH GNAS

Sources for Pituitary Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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