Pituitary-dependent Cushing's Disease malady

MalaCards: Pituitary-dependent Cushing's Disease, also known as pituitary-dependent cushings disease, is related to cushing's syndrome and post-traumatic stress disorder. An important gene associated with Pituitary-dependent Cushing's Disease is CRH (corticotropin releasing hormone), and among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics and Development Prolactin receptor signaling. The compounds epinephrine and gnrh have been mentioned in the context of this disorder. Affiliated tissues include pituitary, and related mouse phenotypes are nervous system and immune system.

Aliases & Descriptions:

pituitary-dependent cushing's disease 6 43 pituitary-dependent cushings disease 8 32

overproduction of acth 6

Diseases related to pituitary-dependent cushing's disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 224)

id	Related Disease	Score	Top Affiliating Genes
1	cushing's syndrome	27.8	POMC, PRL, CRH, NR3C1, SST, GH1
2	post-traumatic stress disorder	13.0	CRH, NR3C1
3	vipoma	13.0	GH1, SST
4	adrenocorticotropic hormone deficiency	13.0	POMC, CRH
5	adrenocortical insufficiency	13.0	CRH, POMC
6	ganglioneuroblastoma	13.0	SST, CRH
7	infantile epileptic encephalopathy	13.0	POMC, CRH
8	panic disorder	12.9	CRH, POMC
9	abcb11-related intrahepatic cholestasis	12.9	CRH, POMC
10	glucagonoma	12.9	GH1, SST
11	adrenocortical hyperplasia	12.9	POMC, CRH
12	isolated growth hormone deficiency	12.9	POMC, GH1
13	short bowel syndrome	12.9	GH1, SST
14	glucocorticoid-remediable aldosteronism	12.9	NR3C1, POMC
15	zollinger-ellison syndrome	12.8	SST, POMC
16	primary pigmented nodular adrenocortical disease	12.8	POMC, NR3C1
17	adrenocortical carcinoma	12.8	CRH, POMC
18	orthostatic hypotension	12.8	POMC, SST
19	adrenal hypoplasia	12.8	POMC, NR3C1
20	allergic encephalomyelitis	12.8	CRH, POMC
21	chromophobe adenoma	12.8	PRL, GH1
22	tsh producing pituitary tumor	12.8	PRL, GH1
23	mccune albright syndrome	12.7	PRL, GH1
24	pituitary gland disease	12.7	PRL, GH1
25	postpartum depression	12.7	CRH, PRL
26	adrenal adenoma	12.7	CRH, POMC
27	pseudohypoparathyroidism type ia	12.7	PRL, GH1
28	empty sella syndrome	12.7	PRL, GH1
29	fetal adenoma	12.7	PRL, GH1
30	borderline personality disorder	12.7	PRL, CRH
31	somatotrophinoma	12.7	GH1, PRL
32	gonadotropin deficiency	12.7	GH1, PRL
33	tetrahydrobiopterin deficiency	12.7	PRL, GH1
34	anovulation	12.7	PRL, CRH
35	substance dependence	12.7	POMC, CRH
36	ganglioneuroma	12.7	POMC, SST
37	personality disorder	12.7	PRL, CRH
38	fragile x-associated primary ovarian insufficiency	12.6	GH1, PRL
39	acanthosis nigricans	12.6	PRL, GH1
40	pseudohypoparathyroidism	12.6	PRL, GH1
41	familial medullary thyroid carcinoma	12.6	SST, POMC
42	back pain	12.6	PRL, CRH
43	polycystic ovary syndrome	12.6	GH1, PRL
44	gonadal disease	12.6	POMC, CRH, GH1
45	delayed puberty	12.6	PRL, GH1
46	hypoadrenalism	12.6	POMC, CRH, GH1
47	focal epilepsy	12.6	SST, PRL
48	lymphocytic hypophysitis	12.6	POMC, PRL
49	neurogenic diabetes insipidus	12.6	POMC, PRL
50	wermer syndrome	12.5	SST, PRL

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to pituitary-dependent cushing's disease:

²²

MGI Mouse Phenotypes related to pituitary-dependent cushing's disease:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system phenotype	MP:0003631	8.1	NR3C1, CRH, PRL, POMC
2	immune system phenotype	MP:0005387	7.6	SST, NR3C1, CRH, PRL, POMC
3	behavior/neurological phenotype	MP:0005386	7.3	POMC, PRL, CRH, NR3C1, SST
4	homeostasis/metabolism phenotype	MP:0005376	7.0	POMC, PRL, CRH, NR3C1, SST, GH1

Articles related to pituitary-dependent cushing's disease:

id	Title	Authors	Year	Affiliating Genes
1	Treatment of pituitary-dependent Cushing's disease with the multireceptor ligand somatostatin analog pasireotide (SOM230): a multicenter, phase II trial. (18957506)	Boscaro M.... Bertherat J.	2009	SST

Genes related to pituitary-dependent cushing's disease according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	CRH	corticotropin releasing hormone	11.0
2	GH1	growth hormone 1	11.0
3	NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	11.0
4	POMC	proopiomelanocortin	11.0
5	PRL	prolactin	11.0
6	SST	somatostatin	11.0	Publications

Pathways related to pituitary-dependent cushing's disease according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Glucocorticoid Pathway (HPA Axis), Pharmacodynamics34	9.1	CRH, POMC
2	Development Prolactin receptor signaling10	8.7	GH1, PRL, NR3C1
3	Neuroactive ligand-receptor interaction20	8.7	GH1, NR3C1, PRL
4	Development_Prolactin receptor signaling41	8.6	PRL, NR3C1, GH1

Compounds related to pituitary-dependent cushing's disease according to GeneDecks:

(show top 50)    (show all 126)

id	Compound	Score	Top Affiliating Genes
1	epinephrine32 9 18 9	12.8	POMC, CRH
2	gnrh32	9.4	POMC, GH1, CRH
3	pitressin32	9.3	POMC, CRH, SST
4	testosterone32 9 18 9	12.1	PRL, SST, CRH
5	proliferin32	9.1	PRL, NR3C1, CRH
6	quinagolide32	9.1	PRL, SST, GH1
7	sulpiride32 9 9	11.0	GH1, CRH, PRL
8	ghrp32	9.0	SST, PRL, GH1
9	clomiphene citrate32	9.0	CRH, PRL, GH1
10	acth 1-2432	9.0	CRH, PRL, POMC
11	lanreotide32	8.9	PRL, SST, GH1
12	betamethasone32 9 9	10.9	NR3C1, GH1, CRH, POMC
13	cortisone32 18	9.9	NR3C1, POMC, CRH, GH1
14	11beta-hydroxysteroid32	8.9	CRH, GH1, NR3C1, POMC
15	fenfluramine32 9 9	10.9	PRL, POMC, CRH
16	cabergoline32 9 9	10.8	GH1, SST, PRL
17	spironolactone32 42 34 9 9	12.8	NR3C1, POMC, CRH
18	metyrapone32 42 9 9	11.8	SST, CRH, NR3C1, POMC
19	ketoconazole32 42 9 18 9	12.8	CRH, NR3C1, POMC, SST
20	pyridostigmine32 9 9	10.7	PRL, SST, GH1, CRH
21	5-hydroxytryptophan32	8.7	GH1, SST, CRH, PRL
22	17-hydroxyprogesterone32 18	9.7	CRH, POMC, PRL
23	desmopressin32 42 9 9	11.7	POMC, CRH, GH1
24	naltrexone32 34 9 9	11.6	PRL, POMC, CRH, GH1
25	11 deoxycortisol32	8.5	CRH, PRL, POMC, NR3C1
26	dehydroepiandrosterone sulfate32	8.5	POMC, PRL, CRH, GH1
27	mirtazapine32 34 9 9	11.5	NR3C1, CRH, PRL, POMC
28	androstenedione32 18	9.5	GH1, CRH, PRL, POMC
29	bromocriptine32 9 9	10.4	PRL, GH1, POMC, SST
30	clonidine32 9 9	10.4	GH1, POMC, SST, PRL
31	estradiol32 9 18 9	11.4	NR3C1, POMC, CRH, PRL
32	mifepristone32 42 9 9	11.4	PRL, CRH, NR3C1, POMC
33	cocaine32 9 9	10.3	PRL, POMC, NR3C1, CRH
34	5-hydroxytryptamine32	8.3	CRH, SST, POMC, PRL
35	acetylcholine32 9 18 9	11.3	GH1, POMC, CRH, NR3C1, SST
36	hexarelin32	8.1	POMC, CRH, PRL, SST, GH1
37	naloxone32 34 9 9	11.1	PRL, POMC, SST, GH1, CRH
38	octreotide32 42 9 9	11.1	SST, PRL, POMC, CRH, GH1
39	opiate32	8.1	GH1, POMC, CRH, PRL, NR3C1
40	dhea32	8.1	GH1, NR3C1, PRL, POMC, CRH
41	corticosterone32 18	9.1	NR3C1, POMC, GH1, PRL, CRH
42	cycloheximide32	8.1	SST, CRH, NR3C1, POMC, GH1
43	thyroxine32 18	9.0	PRL, CRH, SST, GH1, POMC
44	norepinephrine32 9 18 9	11.0	PRL, SST, GH1, CRH, POMC
45	progesterone32 42 9 18 9	11.6	NR3C1, CRH, PRL, POMC, GH1
46	steroid32	7.6	GH1, CRH, PRL, POMC, NR3C1
47	hydrocortisone32 9 9	9.6	PRL, POMC, CRH, NR3C1, SST, GH1
48	acth32	7.6	CRH, NR3C1, SST, GH1, PRL, POMC
49	dopamine32 9 18 9	10.5	PRL, POMC, NR3C1, CRH, SST, GH1
50	dexamethasone32 42 34 9 9	11.5	PRL, CRH, NR3C1, GH1, SST, POMC

Cellular components related to pituitary-dependent cushing's disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	8.5	GH1, SST, CRH, POMC
2	extracellular region	GO:005576	7.3	GH1, SST, CRH, PRL, POMC

Biological processes related to pituitary-dependent cushing's disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	induction of apoptosis by hormones	GO:008628	9.5	SST, CRH
2	adrenal gland development	GO:030325	9.2	NR3C1, CRH
3	JAK-STAT cascade involved in growth hormone signaling pathway	GO:060397	9.2	GH1, PRL
4	positive regulation of JAK-STAT cascade	GO:046427	9.1	GH1, PRL

Molecular functions related to pituitary-dependent cushing's disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	prolactin receptor binding	GO:005148	9.2	GH1, PRL
2	hormone activity	GO:005179	7.3	GH1, SST, CRH, PRL, POMC