MCID: PTT003
MIFTS: 43

Pituitary-Dependent Cushing's Disease

Categories: Endocrine diseases

Aliases & Classifications for Pituitary-Dependent Cushing's Disease

MalaCards integrated aliases for Pituitary-Dependent Cushing's Disease:

Name: Pituitary-Dependent Cushing's Disease 12 14 69
Pituitary-Dependent Cushing Disease 12
Pituitary Acth Hypersecretion 41
Overproduction of Acth 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3946
ICD10 32 E24.0
MeSH 41 D047748
NCIt 46 C113210
SNOMED-CT 64 190502001 9545009
UMLS 69 C0221406

Summaries for Pituitary-Dependent Cushing's Disease

MalaCards based summary : Pituitary-Dependent Cushing's Disease, also known as pituitary-dependent cushing disease, is related to acth-secreting pituitary adenoma and bronchus adenoma. An important gene associated with Pituitary-Dependent Cushing's Disease is SST (Somatostatin), and among its related pathways/superpathways are Peptide ligand-binding receptors and Corticotropin-releasing hormone signaling pathway. The drugs Somatostatin and Liraglutide have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and testes, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Related Diseases for Pituitary-Dependent Cushing's Disease

Diseases related to Pituitary-Dependent Cushing's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 acth-secreting pituitary adenoma 32.7 CRH POMC PRL
2 bronchus adenoma 10.6 POMC SST
3 bronchial adenomas/carcinoids childhood 10.6 POMC SST
4 acidophil adenoma 10.6 POMC SST
5 tsh producing pituitary tumor 10.6 PRL SST
6 generalized resistance to thyroid hormone 10.5 PRL TRH
7 suprasellar meningioma 10.5 POMC TRH
8 pituitary adenoma 1, multiple types 10.5 PRL SST
9 pituitary carcinoma 10.5 CRH POMC SST
10 ectopic cushing syndrome 10.5 CRH POMC SST
11 prolactin producing pituitary tumor 10.5 PRL SST
12 pseudohypoparathyroidism, type ia 10.5 PRL TRH
13 pituitary tumors 10.5 POMC PRL SST
14 adenohypophysitis 10.4 POMC PRL TRH
15 acth deficiency, isolated 10.4 CRH POMC
16 scleredema adultorum 10.4 INS POMC
17 endometriosis of uterus 10.4 GNRH1 PRL
18 sella turcica neoplasm 10.4 GHRH POMC PRL
19 tuberculum sellae meningioma 10.4 GHRH POMC PRL
20 hypogonadotropism 10.4 GNRH1 PRL
21 pancreatic islet cell tumors 10.4 INS SST
22 duodenal somatostatinoma 10.4 INS SST
23 postgastrectomy syndrome 10.4 INS SST
24 postural hypotension 10.4 INS SST
25 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 10.4 CYP21A2 POMC
26 pituitary adenoma 4, acth-secreting 10.3
27 gigantism 10.3 GHRH PRL
28 nelson syndrome 10.3 CRH POMC PRL SST
29 acute adrenal insufficiency 10.3 CYP21A2 POMC
30 glucagonoma 10.3 GHRH SST
31 adrenal cortex disease 10.3 CRH POMC PRL SST
32 diabetes insipidus, neurohypophyseal 10.3 GNRH1 POMC PRL
33 pylorospasm 10.3 HTR4 SST
34 cytochrome p450 oxidoreductase deficiency 10.3 CYP21A2 POMC
35 melancholia 10.3 CRH PRL
36 organ system benign neoplasm 10.3 POMC PRL SST TRH
37 pancreas disease 10.3 INS POMC SST
38 pituitary adenoma, prolactin-secreting 10.3 POMC PRL SST TRH
39 glucose metabolism disease 10.3 INS POMC SST
40 urinary system disease 10.3 CRH INS POMC
41 burns 10.3 CRH INS
42 multiple endocrine neoplasia, type i 10.3 INS PRL SST
43 panic disorder 10.2 CRH GHRH POMC
44 adrenal cortical hypofunction 10.2 CRH CYP21A2 POMC
45 pituitary infarct 10.2 GNRH1 POMC PRL SST
46 chiasmal syndrome 10.2 GNRH1 POMC PRL SST
47 hyperinsulinemic hypoglycemia, familial, 2 10.2 INS SST
48 hypoadrenocorticism, familial 10.2 CRH CYP21A2 POMC
49 laryngeal tuberculosis 10.2 CD59 POMC
50 adrenal carcinoma 10.2 CRH CYP21A2 POMC

Graphical network of the top 20 diseases related to Pituitary-Dependent Cushing's Disease:



Diseases related to Pituitary-Dependent Cushing's Disease

Symptoms & Phenotypes for Pituitary-Dependent Cushing's Disease

MGI Mouse Phenotypes related to Pituitary-Dependent Cushing's Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.22 APEX1 CD59 CRH CYP27A1 GHR GHRH
2 endocrine/exocrine gland MP:0005379 10.18 PRL TRH APEX1 CD59 CRH CYP27A1
3 growth/size/body region MP:0005378 10.15 APEX1 CRH GHR GHRH GNRH1 HSD11B1
4 behavior/neurological MP:0005386 10.13 CRH GHR HSD11B1 HTR4 INS MC3R
5 immune system MP:0005387 10.03 APEX1 CRH GHR GHRH GNRH1 HSD11B1
6 adipose tissue MP:0005375 10 INS MC3R POMC CRH GHR HSD11B1
7 liver/biliary system MP:0005370 9.9 PRL SERPINA6 APEX1 CRH CYP27A1 GHR
8 nervous system MP:0003631 9.73 CRH CYP27A1 GHR GHRH GNRH1 HSD11B1
9 renal/urinary system MP:0005367 9.23 CD59 CRH CYP27A1 GHR GNRH1 INS

Drugs & Therapeutics for Pituitary-Dependent Cushing's Disease

Drugs for Pituitary-Dependent Cushing's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 112)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Somatostatin Approved, Investigational Phase 4,Phase 3,Phase 2 38916-34-6, 51110-01-1 53481605
2
Liraglutide Approved Phase 4 204656-20-2 44147092
3
Metformin Approved Phase 4 657-24-9 4091 14219
4
Zinc Approved, Investigational Phase 4 7440-66-6 32051 23994
5
Lactitol Investigational Phase 4 585-86-4 3871
6 Hormone Antagonists Phase 4,Phase 3,Phase 2,Early Phase 1
7 Hormones Phase 4,Phase 3,Phase 2,Early Phase 1
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Early Phase 1
9 insulin Phase 4
10 Insulin, Globin Zinc Phase 4
11 Dipeptidyl-Peptidase IV Inhibitors Phase 4
12 HIV Protease Inhibitors Phase 4
13 Hypoglycemic Agents Phase 4,Phase 2
14 Incretins Phase 4
15
protease inhibitors Phase 4
16 Sitagliptin Phosphate Phase 4
17
Hydrocortisone Approved, Vet_approved Phase 3,Phase 2 50-23-7 657311 5754
18
Cabergoline Approved Phase 3,Phase 2 81409-90-7 54746
19
Dopamine Approved Phase 3,Phase 2 51-61-6, 62-31-7 681
20
Mifepristone Approved, Investigational Phase 3,Phase 2 84371-65-3 55245
21
Epinephrine Approved, Vet_approved Phase 3,Phase 2 51-43-4 5816
22 Racepinephrine Approved Phase 3,Phase 2 329-65-7
23
Octreotide Approved, Investigational Phase 3 83150-76-9 6400441 383414
24 Orange Approved, Nutraceutical Phase 3
25 Cortisol succinate Phase 3,Phase 2
26 Hydrocortisone 17-butyrate 21-propionate Phase 3,Phase 2
27 Hydrocortisone acetate Phase 3,Phase 2
28 Adrenocorticotropic Hormone Phase 3,Phase 2,Early Phase 1
29 beta-endorphin Phase 3,Phase 2
30 Melanocyte-Stimulating Hormones Phase 3,Phase 2
31 Pharmaceutical Solutions Phase 3
32 Antiparkinson Agents Phase 3,Phase 2
33 Dopamine Agents Phase 3,Phase 2
34 Dopamine agonists Phase 3,Phase 2
35 Neurotransmitter Agents Phase 3,Phase 2
36 Contraceptive Agents Phase 3,Phase 2
37 Contraceptives, Oral Phase 3,Phase 2
38 Contraceptives, Postcoital Phase 3,Phase 2
39 Luteolytic Agents Phase 3,Phase 2
40 Epinephryl borate Phase 3,Phase 2
41 Antineoplastic Agents, Hormonal Phase 3,Phase 2
42 Edotreotide Phase 3
43 Gastrointestinal Agents Phase 3,Phase 2
44 Radiopharmaceuticals Phase 3
45
Bexarotene Approved, Investigational Phase 1, Phase 2 153559-49-0 82146
46
Gefitinib Approved, Investigational Phase 2 184475-35-2 123631
47
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
48
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
49
Rosiglitazone Approved, Investigational Phase 2 122320-73-4 77999
50
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037

Interventional clinical trials:

(show top 50) (show all 56)

# Name Status NCT ID Phase Drugs
1 Adipokine Profile in Patients With Cushing's Disease on Pasireotide Treatment Completed NCT03080181 Phase 4 Pasireotide 0.6 MG/ML
2 Study of Management of Pasireotide-induced Hyperglycemia in Adult Patients With Cushing's Disease or Acromegaly Recruiting NCT02060383 Phase 4 Pasireotide s.c.;Sitagliptin;Liraglutide;Insulin;Pasireotide LAR;Metformin
3 Study to Allow Access to Pasireotide for Patients Benefiting From Pasireotide Treatment in a Novartis-sponsored Study. Recruiting NCT01794793 Phase 4 Pasireotide
4 Efficacy and Safety of Pasireotide Administered Monthly in Patients With Cushing's Disease Completed NCT01374906 Phase 3 SOM230 LAR 30 mg;SOM230 LAR 10 mg
5 Safety and Efficacy of Different Dose Levels of Pasireotide in Patients With de Novo, Persistent or Recurrent Cushing's Disease Completed NCT00434148 Phase 3 Pasireotide
6 An Open-label, Multi-center, Expanded Access Study of Pasireotide s.c. in Patients With Cushing's Disease. Completed NCT01582061 Phase 3 Pasireotide sub-cutaneous
7 Study of Cabergoline in Treatment of Corticotroph Pituitary Tumor Completed NCT00889525 Phase 3 Cabergoline
8 Compassionate Use of CORLUX® (Mifepristone) in the Treatment of Signs and Symptoms of Endogenous Cushing's Syndrome Completed NCT01371565 Phase 3 Mifepristone
9 An Extension Study of CORLUX in the Treatment of Endogenous Cushing's Syndrome Completed NCT00936741 Phase 3 mifepristone
10 A Study of the Efficacy and Safety of CORLUX in the Treatment of Endogenous Cushing's Syndrome Completed NCT00569582 Phase 3 mifepristone
11 Efficacy and Safety Evaluation of Osilodrostat in Cushing's Disease Recruiting NCT02697734 Phase 3 osilodrostat;osilodrostat Placebo
12 Ga-68-DOTATOC -PET in the Management of Pituitary Tumours Recruiting NCT02419664 Phase 3
13 Safety and Efficacy of LCI699 for the Treatment of Patients With Cushing's Disease Active, not recruiting NCT02180217 Phase 3 LCI699
14 Mifepristone in Children With Refractory Cushing's Disease Withdrawn NCT01925092 Phase 3 mifepristone
15 Preoperative Bexarotene Treatment for Cushing's Disease Unknown status NCT00845351 Phase 1, Phase 2 Bexarotene
16 Targeted Therapy With Gefitinib in Patients With USP8-mutated Cushing's Disease Unknown status NCT02484755 Phase 2 Gefitinib
17 Reduction by Pasireotide of the Effluent Volume in High-output Enterostomy in Patients Refractory to Usual Medical Treatment Unknown status NCT02713776 Phase 2 Pasireotide;Placebo
18 Extension Study to Assess the Safety and Efficacy of Pasireotide in Patients With Cushing's Disease Completed NCT00171951 Phase 2 Pasireotide
19 A Study to Assess SOM230 in Patients With Pituitary Cushing's Disease Completed NCT00088608 Phase 2 SOM230 s.c.
20 Treatment of Cushing's Disease With R-roscovitine Recruiting NCT02160730 Phase 2 R-roscovitine
21 Targeting Iatrogenic Cushing's Syndrome With 11β-hydroxysteroid Dehydrogenase Type 1 Inhibition Recruiting NCT03111810 Phase 2 AZD4017 and prednisolone;Placebo Oral Tablet and prednisolone
22 Study of Efficacy and Safety of Osilodrostat in Cushing's Syndrome Recruiting NCT02468193 Phase 2 Osilodrostat
23 Targeted Therapy With Lapatinib in Patients With Recurrent Pituitary Tumors Resistant to Standard Therapy Recruiting NCT00939523 Phase 2 Lapatinib
24 Study to Evaluate CORT125134 in Patients With Cushing's Syndrome Recruiting NCT02804750 Phase 2 CORT125134
25 Study of the Efficacy and Safety of Pasireotide s.c. +/- Cabergoline in Patients With Cushing's Disease Active, not recruiting NCT01915303 Phase 2 Pasireotide with or without cabergoline
26 Safety and Efficacy of LCI699 in Cushing's Disease Patients. Active, not recruiting NCT01331239 Phase 2 LCI699
27 Rosiglitazone in Treating Patients With Newly Diagnosed ACTH-Secreting Pituitary Tumor (Cushing Disease) Terminated NCT00612066 Phase 2 rosiglitazone maleate
28 Rosiglitazone in Treating Patients With Pituitary Tumors Terminated NCT00616642 Phase 2 rosiglitazone maleate
29 Pasireotide Therapy in Patients With Nelson's Syndrome Terminated NCT01617733 Phase 2 Pasireotide
30 Prospective, Open-Label, Multicenter, International Study of Mifepristone for Symptomatic Treatment of Cushing's Syndrome Caused by Ectopic Adrenal Corticotrophin Hormone (ACTH) Secretion Terminated NCT00422201 Phase 2 Mifepristone
31 Phase II Study of SOM230 in Patients With Recurrent or Progressive Meningioma Terminated NCT00813592 Phase 2 SOM230B
32 Assessment of Persistent Cognitive Impairment After Cure of Cushing's Disease Unknown status NCT02603653
33 Study of Depression, Peptides, and Steroids in Cushing's Syndrome Unknown status NCT00004334
34 Anesthesia Management of Retroperitoneal Adrenalectomies Unknown status NCT00894335
35 The Factors Associated With the Recurrence in Patients With Cushing Disease Completed NCT02233335
36 Cognition, Steroids, and Imaging in Cushings Disease Completed NCT00081341
37 Effects of Hormone Stimulation on Brain Scans for Cushing s Disease Completed NCT01459237 Early Phase 1 Acthrel
38 Jugular Vein Sampling for Hormone Levels for the Diagnosis of Cushing Syndrome Completed NCT00001453
39 Examination of Brain Serotonin Receptors in Patients With Mood Disorders Completed NCT00026832
40 Obesity as a Risk Factor for Musculoskeletal Diseases in the U.S. Air Force: Associations and Implications for Force Readiness Completed NCT01613001
41 Cushing's Disease Complications Recruiting NCT02568982
42 Long Term Safety and Efficacy of Pasireotide s.c. in Patients With Cushing's Disease Recruiting NCT02310269 SOM230
43 Adrenal Venous Sampling in Patients With Overt or Subclinical Cushings Syndrome, and Bilateral Adrenal Tumors Recruiting NCT02543697
44 Collecting Information About Treatment Results for Patients With Cushing's Syndrome Recruiting NCT03364803
45 Mutations of Glucocorticoid Receptor in Bilateral Adrenal Hyperplasia Recruiting NCT02810496
46 Mifepristone for Breast Cancer Patients With Higher Levels of Progesterone Receptor Isoform A Than Isoform B. Recruiting NCT02651844 Mifepristone
47 An Investigation of Pituitary Tumors and Related Hypothalmic Disorders Recruiting NCT00001595
48 Quality of Life, Fatigue and Cognitive, Affective and Emotional Dysfunction in Patients With Cushing's Syndrome Recruiting NCT03211624
49 The Circadian Rhythm in CusHing SyndrOme in Active Phase and dUring RemiSsion (TheHOURS) Recruiting NCT03343470
50 Dynamic Hormone Diagnostics in Endocrine Disease Recruiting NCT02934399

Search NIH Clinical Center for Pituitary-Dependent Cushing's Disease

Cochrane evidence based reviews: pituitary acth hypersecretion

Genetic Tests for Pituitary-Dependent Cushing's Disease

Anatomical Context for Pituitary-Dependent Cushing's Disease

MalaCards organs/tissues related to Pituitary-Dependent Cushing's Disease:

38
Pituitary, Brain, Testes

Publications for Pituitary-Dependent Cushing's Disease

Articles related to Pituitary-Dependent Cushing's Disease:

(show all 13)
# Title Authors Year
1
Treatment of pituitary-dependent Cushing's disease with the multireceptor ligand somatostatin analog pasireotide (SOM230): a multicenter, phase II trial. ( 18957506 )
2009
2
Greater disorderliness of ACTH and cortisol release accompanies pituitary-dependent Cushing's disease. ( 9150699 )
1997
3
Risk factors and long-term outcome in pituitary-dependent Cushing's disease. ( 8675592 )
1996
4
Failure of hypophysectomy to correct pituitary-dependent Cushing's disease in two patients. ( 3190383 )
1988
5
Corticotrophin-releasing factor-test used with bilateral, simultaneous inferior petrosal sinus blood-sampling for the diagnosis of pituitary-dependent Cushing's disease. ( 2820618 )
1986
6
Is it possible to diagnose pituitary-dependent Cushing's disease? ( 3000267 )
1985
7
A case of pituitary dependent Cushing's disease with clinical and biochemical features of the ectopic ACTH syndrome. ( 2985302 )
1985
8
Sodium valproate and metyrapone for pituitary-dependent Cushing's disease. ( 6147673 )
1984
9
Responsiveness of the hypophyseal-adrenocortical axis to corticotropin-releasing factor in pituitary-dependent Cushing's disease. ( 6308029 )
1983
10
Simultaneous bilateral venous sampling for adrenocorticotropin in pituitary-dependent cushing's disease: evidence for lateralization of pituitary venous drainage. ( 6311861 )
1983
11
Remission of pituitary-dependent Cushing's disease after removal of nonneoplastyic pituitary gland. ( 6252859 )
1980
12
Pituitary-dependent Cushing's disease. ( 193608 )
1977
13
Pituitary-dependent Cushing's disease. ( 858043 )
1977

Variations for Pituitary-Dependent Cushing's Disease

Expression for Pituitary-Dependent Cushing's Disease

Search GEO for disease gene expression data for Pituitary-Dependent Cushing's Disease.

Pathways for Pituitary-Dependent Cushing's Disease

GO Terms for Pituitary-Dependent Cushing's Disease

Cellular components related to Pituitary-Dependent Cushing's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 CD59 CRH GHR GHRH GNRH1 INS
2 extracellular region GO:0005576 9.36 CD59 CRH GHR GHRH GNRH1 INS
3 endosome lumen GO:0031904 9.16 INS PRL

Biological processes related to Pituitary-Dependent Cushing's Disease according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor signaling pathway GO:0007186 9.81 CRH GHRH GNRH1 HTR4 INS MC3R
2 cell-cell signaling GO:0007267 9.73 GHRH GNRH1 INS POMC SST TRH
3 steroid metabolic process GO:0008202 9.71 CRH CYP21A2 HSD11B1
4 response to ethanol GO:0045471 9.69 CRH GNRH1 TRH
5 female pregnancy GO:0007565 9.63 CRH GNRH1 PRL
6 positive regulation of JAK-STAT cascade GO:0046427 9.52 GHR PRL
7 positive regulation of cAMP biosynthetic process GO:0030819 9.5 CRH GHRH MC3R
8 regulation of receptor activity GO:0010469 9.5 GHRH GNRH1 INS POMC PRL SST
9 response to corticosterone GO:0051412 9.49 CRH TRH
10 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.48 GHR PRL
11 regulation of appetite GO:0032098 9.43 HTR4 POMC
12 negative regulation of feeding behavior GO:2000252 9.4 INS TRH
13 hormone-mediated apoptotic signaling pathway GO:0008628 9.37 CRH SST
14 glucocorticoid biosynthetic process GO:0006704 8.8 CRH CYP21A2 HSD11B1

Molecular functions related to Pituitary-Dependent Cushing's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.35 APEX1 CYP21A2 CYP27A1 HSD11B1 NNT
2 hormone activity GO:0005179 9.17 CRH GNRH1 INS POMC PRL SST

Sources for Pituitary-Dependent Cushing's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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