MCID: PTT003
MIFTS: 31

Pituitary-Dependent Cushing's Disease malady

Summaries for Pituitary-Dependent Cushing's Disease

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33MalaCards
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MalaCards: Pituitary-Dependent Cushing's Disease, also known as pituitary-dependent cushings disease, is related to fibromyalgia and irritable bowel syndrome. An important gene associated with Pituitary-Dependent Cushing's Disease is CRH (corticotropin releasing hormone), and among its related pathways are Prolactin receptor signaling and Glucocorticoid Pathway (HPA Axis), Pharmacodynamics. The compounds gnrh and dopamine have been mentioned in the context of this disorder. Affiliated tissues include pituitary, and related mouse phenotypes are endocrine/exocrine gland and integument.

Aliases & Classifications for Pituitary-Dependent Cushing's Disease

Sources:
8Disease Ontology, 61UMLS, 10DISEASES, 45Novoseek, 57SNOMED-CT, 35MeSH
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Aliases & Descriptions:

pituitary-dependent cushing's disease 8 61
pituitary-dependent cushings disease 10 45
overproduction of acth 8


External Ids:

Disease Ontology8 DOID:3946
SNOMED-CT57 9545009, 190502001
MeSH35 D047748

Related Diseases for Pituitary-Dependent Cushing's Disease

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17GeneCards, 18GeneDecks
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Diseases related to Pituitary-Dependent Cushing's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 113)
idRelated DiseaseScoreTop Affiliating Genes
1fibromyalgia10.0CRH
2irritable bowel syndrome10.0CRH
3seasonal affective disorder10.0CRH
4anxiety disorder10.0CRH
5substance abuse10.0CRH
6carney complex10.0POMC
7cocaine dependence10.0POMC
8thyroiditis10.0POMC
9multiple sclerosis10.0POMC
10cholera10.0POMC
11fibrous dysplasia10.0GH1
12arthritis10.0POMC
13adrenal carcinoma10.0POMC
14alcohol dependence10.0CRH
15meningioma10.0SST
16prion disease10.0POMC
17prader-willi syndrome10.0GH1
18dementia10.0NR3C1
19zollinger-ellison syndrome10.0SST
20essential hypertension10.0NR3C1
21leukemia10.0NR3C1
22ganglioneuroma10.0POMC
23osteosarcoma10.0NR3C1
24infertility10.0PRL
25addison's disease10.0CRH, POMC
26hypogonadotropism10.0PRL
27melancholia10.0CRH, POMC
28endogenous depression10.0POMC, CRH
29infantile epileptic encephalopathy10.0POMC, CRH
30prostate cancer10.0NR3C1
31panic disorder10.0CRH, POMC
32pancreatitis10.0SST
33alzheimer's disease10.0CRH, SST
34anovulation10.0PRL
35bronchial endocrine tumor10.0SST, POMC
36gastrinoma10.0SST, GH1
37lung cancer10.0SST, POMC
38hypokalemia10.0NR3C1, POMC
39systemic lupus erythematosus10.0PRL
40leydig cell tumor10.0POMC
41gynecomastia10.0PRL
42hyperinsulinism10.0SST, GH1
43glucose intolerance10.0NR3C1, GH1
44adrenocortical carcinoma10.0CRH, POMC
45vipoma10.0GH1, SST
46dopa-responsive cervical dystonia10.0CRH, NR3C1
47glucocorticoid-remediable aldosteronism10.0POMC, NR3C1
48adrenal adenoma10.0POMC, CRH
49adenocarcinoma10.0SST, NR3C1
50glucagonoma10.0SST, GH1

Graphical network of the top 20 diseases related to Pituitary-Dependent Cushing's Disease:



Diseases related to pituitary-dependent cushing's disease

Clinical Features for Pituitary-Dependent Cushing's Disease

Drugs & Therapeutics for Pituitary-Dependent Cushing's Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Pituitary-Dependent Cushing's Disease

Drug clinical trials:

Search ClinicalTrials for Pituitary-Dependent Cushing's Disease

Search NIH Clinical Center for Pituitary-Dependent Cushing's Disease

Search CenterWatch for Pituitary-Dependent Cushing's Disease

Genetic Tests for Pituitary-Dependent Cushing's Disease

Anatomical Context for Pituitary-Dependent Cushing's Disease

Sources:
33MalaCards
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MalaCards organs/tissues related to Pituitary-Dependent Cushing's Disease:

33
Pituitary

Animal Models for Pituitary-Dependent Cushing's Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Pituitary-Dependent Cushing's Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.0NR3C1
2MP:00107718.2CRH, NR3C1, POMC, PRL
3MP:00053708.1NR3C1, GH1, PRL, POMC
4MP:00053867.6CRH, PRL, NR3C1, SST, POMC
5MP:00053787.6SST, NR3C1, GH1, POMC, CRH
6MP:00053877.5POMC, SST, NR3C1, PRL, CRH
7MP:00036317.3NR3C1, SST, PRL, GH1, CRH, POMC
8MP:00053767.2PRL, SST, CRH, POMC, GH1, NR3C1

Publications for Pituitary-Dependent Cushing's Disease

Sources:
51PubMed
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Articles related to Pituitary-Dependent Cushing's Disease:

idTitleAuthorsYear
1
Treatment of pituitary-dependent Cushing's disease with the multireceptor ligand somatostatin analog pasireotide (SOM230): a multicenter, phase II trial. (18957506)
2009
2
Corticotrophin-releasing factor-test used with bilateral, simultaneous inferior petrosal sinus blood-sampling for the diagnosis of pituitary-dependent Cushing's disease. (2820618)
1986
3
A case of pituitary dependent Cushing's disease with clinical and biochemical features of the ectopic ACTH syndrome. (2985302)
1985
4
Sodium valproate and metyrapone for pituitary-dependent Cushing's disease. (6147673)
1984
5
Simultaneous bilateral venous sampling for adrenocorticotropin in pituitary-dependent cushing's disease: evidence for lateralization of pituitary venous drainage. (6311861)
1983

Genetic Variations for Pituitary-Dependent Cushing's Disease

Expression for genes affiliated with Pituitary-Dependent Cushing's Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pituitary-Dependent Cushing's Disease

Search GEO for disease gene expression data for Pituitary-Dependent Cushing's Disease.

Pathways for genes affiliated with Pituitary-Dependent Cushing's Disease

Sources:
54Reactome, 50PharmGKB, 52QIAGEN, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG
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Compounds for genes affiliated with Pituitary-Dependent Cushing's Disease

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
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Compounds related to Pituitary-Dependent Cushing's Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 133)
idCompoundScoreTop Affiliating Genes
1gnrh4510.3GH1
2dopamine45 29 11 2412.9NR3C1, CRH
3norepinephrine45 11 2411.5POMC, PRL
4estradiol45 11 2411.5POMC, PRL
5pitressin459.5SST, POMC, CRH
6acth 1-24459.1PRL, POMC, CRH
7bromocriptine29 45 1111.1POMC, SST, PRL
8fenfluramine29 45 1111.0POMC, CRH, PRL
9quinagolide459.0GH1, SST, PRL
10sulpiride45 29 1111.0CRH, PRL, GH1
11spironolactone50 45 60 29 1113.0NR3C1, CRH, POMC
12proliferin459.0CRH, NR3C1, PRL
13ghrp458.9SST, PRL, GH1
14clomiphene citrate458.9CRH, GH1, PRL
15betamethasone45 119.9POMC, CRH, GH1, NR3C1
16metyrapone60 45 1110.9CRH, NR3C1, SST, POMC
17cortisone45 249.9NR3C1, POMC, CRH, GH1
18lanreotide45 299.9SST, GH1, PRL
1911beta-hydroxysteroid458.9POMC, NR3C1, GH1, CRH
2017-hydroxyprogesterone45 249.9CRH, PRL, POMC
21ketoconazole45 29 11 2411.8NR3C1, POMC, SST, CRH
22desmopressin45 60 29 1111.8GH1, CRH, POMC
23cabergoline29 45 1110.8PRL, SST, GH1
24naltrexone45 50 29 1111.7POMC, CRH, GH1, PRL
25dehydroepiandrosterone sulfate458.6POMC, CRH, PRL, GH1
265-hydroxytryptophan458.6GH1, SST, PRL, CRH
27pyridostigmine45 119.6PRL, GH1, CRH, SST
2811 deoxycortisol458.6POMC, NR3C1, PRL, CRH
29mirtazapine50 45 1110.6POMC, NR3C1, CRH, PRL
30androstenedione45 249.6POMC, PRL, GH1, CRH
31clonidine45 29 1110.5POMC, PRL, GH1, SST
325-hydroxytryptamine458.5CRH, PRL, SST, POMC
33gaba458.5CRH, NR3C1, POMC, SST
34mifepristone45 60 29 1111.4NR3C1, PRL, CRH, POMC
35cocaine45 119.4NR3C1, CRH, PRL, POMC
36acetylcholine45 50 29 11 2412.3SST, CRH, GH1, POMC, NR3C1
37hexarelin45 299.2CRH, POMC, SST, GH1, PRL
38naloxone45 50 29 1111.2PRL, SST, CRH, GH1, POMC
39octreotide45 60 29 1111.2POMC, SST, CRH, GH1, PRL
40thyroxine45 249.1GH1, POMC, SST, PRL, CRH
41epinephrine45 11 2410.1GH1, POMC, CRH, SST, PRL
42opiate458.1CRH, PRL, NR3C1, POMC, GH1
43dhea458.1GH1, POMC, NR3C1, PRL, CRH
44corticosterone45 60 2410.1PRL, CRH, NR3C1, GH1, POMC
45progesterone45 60 29 11 2411.8GH1, POMC, CRH, NR3C1, PRL
46hydrocortisone45 2 60 1110.6SST, CRH, GH1, PRL, NR3C1, POMC
47acth457.6NR3C1, SST, POMC, PRL, CRH, GH1
48steroid457.5CRH, POMC, NR3C1, GH1, PRL
49testosterone45 60 11 2410.5POMC, SST, NR3C1, PRL, GH1, CRH
50dexamethasone45 50 29 1110.5GH1, POMC, PRL, CRH, NR3C1, SST

GO Terms for genes affiliated with Pituitary-Dependent Cushing's Disease

Sources:
16Gene Ontology
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Cellular components related to Pituitary-Dependent Cushing's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.2POMC, PRL
2extracellular spaceGO:0056158.3CRH, GH1, SST, POMC
3extracellular regionGO:0055767.6POMC, SST, PRL, GH1, CRH

Biological processes related to Pituitary-Dependent Cushing's Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1hormone-mediated apoptotic signaling pathwayGO:0086289.7SST, CRH
2adrenal gland developmentGO:0303259.5NR3C1, CRH
3parturitionGO:0075679.4PRL, CRH
4positive regulation of JAK-STAT cascadeGO:0464279.2PRL, GH1
5JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.1GH1, PRL
6response to nutrientGO:0075849.1SST, PRL
7response to estradiol stimulusGO:0323558.8PRL, GH1
8response to drugGO:0424938.6SST, PRL, CRH

Molecular functions related to Pituitary-Dependent Cushing's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1prolactin receptor bindingGO:0051489.1PRL, GH1
2hormone activityGO:0051797.4POMC, SST, PRL, GH1, CRH

Products for genes affiliated with Pituitary-Dependent Cushing's Disease

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  • Proteins
  • Lysates
  • Antibodies

Sources for Pituitary-Dependent Cushing's Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet