MCID: PTT003
MIFTS: 41

Pituitary-Dependent Cushing's Disease malady

Summaries for Pituitary-Dependent Cushing's Disease

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MalaCards: Pituitary-Dependent Cushing's Disease, also known as pituitary-dependent cushings disease, is related to acth-secreting pituitary adenoma and cushing's syndrome. An important gene associated with Pituitary-Dependent Cushing's Disease is CRH (corticotropin releasing hormone), and among its related pathways are Prolactin receptor signaling and Glucocorticoid Pathway (HPA Axis), Pharmacodynamics. The compounds gnrh and dopamine have been mentioned in the context of this disorder. Affiliated tissues include pituitary and testes, and related mouse phenotypes are endocrine/exocrine gland and integument.

Aliases & Classifications for Pituitary-Dependent Cushing's Disease

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

pituitary-dependent cushing's disease 8 60
pituitary-dependent cushings disease 10 44
overproduction of acth 8


External Ids:

Disease Ontology8 DOID:3946
SNOMED-CT56 9545009, 190502001
MeSH34 D047748

Related Diseases for Pituitary-Dependent Cushing's Disease

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17GeneCards, 18GeneDecks
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Diseases related to Pituitary-Dependent Cushing's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 113)
idRelated DiseaseScoreTop Affiliating Genes
1acth-secreting pituitary adenoma30.5CRH, GH1, POMC, NR3C1, PRL
2cushing's syndrome30.3CRH, PRL, NR3C1, SST, POMC
3fibromyalgia10.0CRH
4irritable bowel syndrome10.0CRH
5seasonal affective disorder10.0CRH
6anxiety disorder10.0CRH
7substance abuse10.0CRH
8carney complex10.0POMC
9cocaine dependence10.0POMC
10thyroiditis10.0POMC
11multiple sclerosis10.0POMC
12cholera10.0POMC
13fibrous dysplasia10.0GH1
14arthritis10.0POMC
15adrenal carcinoma10.0POMC
16alcohol dependence10.0CRH
17meningioma10.0SST
18prion disease10.0POMC
19prader-willi syndrome10.0GH1
20dementia10.0NR3C1
21zollinger-ellison syndrome10.0SST
22essential hypertension10.0NR3C1
23leukemia10.0NR3C1
24ganglioneuroma10.0POMC
25osteosarcoma10.0NR3C1
26infertility10.0PRL
27addison's disease10.0CRH, POMC
28hypogonadotropism10.0PRL
29melancholia10.0CRH, POMC
30endogenous depression10.0POMC, CRH
31infantile epileptic encephalopathy10.0POMC, CRH
32prostate cancer10.0NR3C1
33panic disorder10.0CRH, POMC
34pancreatitis10.0SST
35alzheimer's disease10.0CRH, SST
36anovulation10.0PRL
37bronchial endocrine tumor10.0SST, POMC
38gastrinoma10.0SST, GH1
39lung cancer10.0SST, POMC
40hypokalemia10.0NR3C1, POMC
41systemic lupus erythematosus10.0PRL
42leydig cell tumor10.0POMC
43gynecomastia10.0PRL
44hyperinsulinism10.0SST, GH1
45glucose intolerance10.0NR3C1, GH1
46adrenocortical carcinoma10.0CRH, POMC
47vipoma10.0GH1, SST
48bipolar disorder10.0CRH, NR3C1
49glucocorticoid-remediable aldosteronism10.0POMC, NR3C1
50adrenal adenoma10.0POMC, CRH

Graphical network of the top 20 diseases related to Pituitary-Dependent Cushing's Disease:



Diseases related to pituitary-dependent cushing's disease

Clinical Features for Pituitary-Dependent Cushing's Disease

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Drugs & Therapeutics for Pituitary-Dependent Cushing's Disease

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Pituitary-Dependent Cushing's Disease

Genetic Tests for Pituitary-Dependent Cushing's Disease

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Anatomical Context for Pituitary-Dependent Cushing's Disease

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32MalaCards
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MalaCards organs/tissues related to Pituitary-Dependent Cushing's Disease:

32
Pituitary, Testes

Animal Models for Pituitary-Dependent Cushing's Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pituitary-Dependent Cushing's Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.0NR3C1
2MP:00107718.2POMC, NR3C1, PRL, CRH
3MP:00053708.1POMC, NR3C1, PRL, GH1
4MP:00053867.6CRH, PRL, NR3C1, SST, POMC
5MP:00053787.6CRH, GH1, NR3C1, SST, POMC
6MP:00053877.5POMC, SST, NR3C1, PRL, CRH
7MP:00036317.3POMC, CRH, GH1, PRL, NR3C1, SST
8MP:00053767.2CRH, GH1, PRL, NR3C1, SST, POMC

Publications for Pituitary-Dependent Cushing's Disease

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50PubMed
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Articles related to Pituitary-Dependent Cushing's Disease:

(show all 13)
idTitleAuthorsYear
1
Treatment of pituitary-dependent Cushing's disease with the multireceptor ligand somatostatin analog pasireotide (SOM230): a multicenter, phase II trial. (18957506)
2009
2
Greater disorderliness of ACTH and cortisol release accompanies pituitary-dependent Cushing's disease. (9150699)
1997
3
Risk factors and long-term outcome in pituitary-dependent Cushing's disease. (8675592)
1996
4
Failure of hypophysectomy to correct pituitary-dependent Cushing's disease in two patients. (3190383)
1988
5
Corticotrophin-releasing factor-test used with bilateral, simultaneous inferior petrosal sinus blood-sampling for the diagnosis of pituitary-dependent Cushing's disease. (2820618)
1986
6
Is it possible to diagnose pituitary-dependent Cushing's disease? (3000267)
1985
7
A case of pituitary dependent Cushing's disease with clinical and biochemical features of the ectopic ACTH syndrome. (2985302)
1985
8
Sodium valproate and metyrapone for pituitary-dependent Cushing's disease. (6147673)
1984
9
Simultaneous bilateral venous sampling for adrenocorticotropin in pituitary-dependent cushing's disease: evidence for lateralization of pituitary venous drainage. (6311861)
1983
10
Responsiveness of the hypophyseal-adrenocortical axis to corticotropin-releasing factor in pituitary-dependent Cushing's disease. (6308029)
1983
11
Remission of pituitary-dependent Cushing's disease after removal of nonneoplastyic pituitary gland. (6252859)
1980
12
Pituitary-dependent Cushing's disease. (858043)
1977
13
Pituitary-dependent Cushing's disease. (193608)
1977

Genetic Variations for Pituitary-Dependent Cushing's Disease

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Expression for genes affiliated with Pituitary-Dependent Cushing's Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pituitary-Dependent Cushing's Disease

Search GEO for disease gene expression data for Pituitary-Dependent Cushing's Disease.

Pathways for genes affiliated with Pituitary-Dependent Cushing's Disease

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53Reactome, 49PharmGKB, 51QIAGEN, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG
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Compounds for genes affiliated with Pituitary-Dependent Cushing's Disease

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Pituitary-Dependent Cushing's Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 133)
idCompoundScoreTop Affiliating Genes
1gnrh4410.3GH1
2dopamine44 28 11 2412.9NR3C1, CRH
3norepinephrine44 11 2411.5POMC, PRL
4estradiol44 11 2411.5POMC, PRL
5pitressin449.5SST, POMC, CRH
6acth 1-24449.1PRL, POMC, CRH
7bromocriptine28 44 1111.1POMC, SST, PRL
8fenfluramine28 44 1111.0POMC, CRH, PRL
9quinagolide449.0GH1, SST, PRL
10sulpiride44 28 1111.0CRH, PRL, GH1
11spironolactone49 44 59 28 1113.0NR3C1, CRH, POMC
12proliferin449.0CRH, NR3C1, PRL
13ghrp448.9SST, PRL, GH1
14clomiphene citrate448.9CRH, GH1, PRL
15betamethasone44 119.9POMC, CRH, GH1, NR3C1
16metyrapone59 44 1110.9CRH, NR3C1, SST, POMC
17cortisone44 249.9NR3C1, POMC, CRH, GH1
18lanreotide44 289.9SST, GH1, PRL
1911beta-hydroxysteroid448.9POMC, NR3C1, GH1, CRH
2017-hydroxyprogesterone44 249.9CRH, PRL, POMC
21ketoconazole44 28 11 2411.8NR3C1, POMC, SST, CRH
22desmopressin44 59 28 1111.8GH1, CRH, POMC
23cabergoline28 44 1110.8PRL, SST, GH1
24naltrexone44 49 28 1111.7POMC, CRH, GH1, PRL
25dehydroepiandrosterone sulfate448.6POMC, CRH, PRL, GH1
265-hydroxytryptophan448.6GH1, SST, PRL, CRH
27pyridostigmine44 119.6PRL, GH1, CRH, SST
2811 deoxycortisol448.6POMC, NR3C1, PRL, CRH
29mirtazapine49 44 1110.6POMC, NR3C1, CRH, PRL
30androstenedione44 249.6POMC, PRL, GH1, CRH
31clonidine44 28 1110.5POMC, PRL, GH1, SST
325-hydroxytryptamine448.5CRH, PRL, SST, POMC
33gaba448.5CRH, NR3C1, POMC, SST
34mifepristone44 59 28 1111.4NR3C1, PRL, CRH, POMC
35cocaine44 119.4NR3C1, CRH, PRL, POMC
36acetylcholine44 49 28 11 2412.3SST, CRH, GH1, POMC, NR3C1
37hexarelin44 289.2CRH, POMC, SST, GH1, PRL
38naloxone44 49 28 1111.2PRL, SST, CRH, GH1, POMC
39octreotide44 59 28 1111.2POMC, SST, CRH, GH1, PRL
40thyroxine44 249.1GH1, POMC, SST, PRL, CRH
41epinephrine44 11 2410.1GH1, POMC, CRH, SST, PRL
42opiate448.1CRH, PRL, NR3C1, POMC, GH1
43dhea448.1GH1, POMC, NR3C1, PRL, CRH
44corticosterone44 59 2410.1PRL, CRH, NR3C1, GH1, POMC
45progesterone44 59 28 11 2411.8GH1, POMC, CRH, NR3C1, PRL
46hydrocortisone44 2 59 1110.6SST, CRH, GH1, PRL, NR3C1, POMC
47acth447.6NR3C1, SST, POMC, PRL, CRH, GH1
48steroid447.5CRH, POMC, NR3C1, GH1, PRL
49testosterone44 59 11 2410.5POMC, SST, NR3C1, PRL, GH1, CRH
50dexamethasone44 49 28 1110.5GH1, POMC, PRL, CRH, NR3C1, SST

GO Terms for genes affiliated with Pituitary-Dependent Cushing's Disease

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16Gene Ontology
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Cellular components related to Pituitary-Dependent Cushing's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.2POMC, PRL
2extracellular spaceGO:0056158.3CRH, GH1, SST, POMC
3extracellular regionGO:0055767.6POMC, SST, PRL, GH1, CRH

Biological processes related to Pituitary-Dependent Cushing's Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1hormone-mediated apoptotic signaling pathwayGO:0086289.7SST, CRH
2adrenal gland developmentGO:0303259.5NR3C1, CRH
3parturitionGO:0075679.4PRL, CRH
4positive regulation of JAK-STAT cascadeGO:0464279.2PRL, GH1
5JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.1GH1, PRL
6response to nutrientGO:0075849.1SST, PRL
7response to estradiol stimulusGO:0323558.8PRL, GH1
8response to drugGO:0424938.6SST, PRL, CRH

Molecular functions related to Pituitary-Dependent Cushing's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1prolactin receptor bindingGO:0051489.1PRL, GH1
2hormone activityGO:0051797.4POMC, SST, PRL, GH1, CRH

Products for genes affiliated with Pituitary-Dependent Cushing's Disease

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Sources for Pituitary-Dependent Cushing's Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet