Pituitary Hormone Deficiency malady

MalaCards: Pituitary Hormone Deficiency, also known as hypopituitarism, is related to combined pituitary hormone deficiency and hypopituitarism. An important gene associated with Pituitary Hormone Deficiency is PROP1 (PROP paired-like homeobox 1), and among its related pathways are Glucocorticoid Pathway (HPA Axis), Pharmacodynamics and Transcription Receptor-mediated HIF regulation. The compounds quinagolide and acth 1-24 have been mentioned in the context of this disorder. Affiliated tissues include thyroid, adrenal gland and pituitary, and related mouse phenotypes are hearing/vestibular/ear and endocrine/exocrine gland.

pituitary hormone deficiency 7 hypopituitarism 43

Diseases related to pituitary hormone deficiency by text searches and GeneDecks gene sharing:

(show top 50)    (show all 306)

id	Related Disease	Score	Top Affiliating Genes
1	combined pituitary hormone deficiency	32.0	RBM28, PBX1, LHX3, LHX4, INS, IGFBP3
2	hypopituitarism	30.8	PBX1, LHX3, LHX4, INS, IGFBP3, IGF1
3	septooptic dysplasia	29.6	HESX1, SOD1
4	borjeson-forssman-lehmann syndrome	28.3	LHX3, LHX4, PHF6, HESX1, PROP1, SOX3
5	sheehan syndrome	28.2	INS, IGF1, CRH, PRL, POMC
6	adrenal hypoplasia	28.0	NR0B1, NR5A1, POMC
7	traumatic brain injury	27.7	INS, IGF1, GH1, CRH, PRL, SOD1
8	brain injury	27.6	INS, IGF1, GH1, CRH, PRL, SOD1
9	pituitary hypoplasia	27.6	PBX1, LHX3, LHX4, GH1, OTX2, HESX1
10	anophthalmia	27.5	LHX4, INS, OTX2, HESX1, PRL, SOD1
11	adrenocorticotropic hormone deficiency	27.3	CRH, POMC
12	acid-labile subunit	27.1	IGFBP3, IGF1, GH1
13	turner syndrome	27.0	IGFBP3, IGF1, GH1
14	lymphocytic hypophysitis	27.0	IGF1, PRL, POMC
15	panhypopituitarism	26.8	LHX3, LHX4, IGF1, GH1, HESX1, TSHB
16	hemorrhagic fever with renal syndrome	26.8	INS, IGF1, PRL
17	pituitary apoplexy	26.6	INS, GH1, PRL, POMC
18	empty sella syndrome	26.5	INS, IGFBP3, PRL, POMC
19	headache	26.2	INS, IGF1, PRL, SOD1
20	growth hormone deficiency	25.6	PBX1, LHX3, LHX4, INS, IGFBP3, IGF1
21	21-hydroxylase deficiency	25.4	NR0B1, NR5A1, CRH, POMC
22	hyperprolactinemia	25.2	INS, IGFBP3, IGF1, GH1, CRH, PRL
23	klinefelter's syndrome	24.6	INS, NR0B1, NR5A1, PRL, PROP1, POMC
24	myotonic dystrophy	24.5	INS, IGFBP3, IGF1, GH1, CRH, PRL
25	acromegaly	24.4	PBX1, INS, IGFBP3, IGF1, GH1, CRH
26	anorexia nervosa	24.0	PBX1, INS, IGFBP3, IGF1, GH1, CRH
27	hypothyroidism	23.7	PBX1, LHX3, LHX4, INS, IGFBP3, IGF1
28	obesity	22.7	PBX1, INS, IGFBP3, IGF1, GH1, NR0B1
29	pituitary adenoma	22.1	PBX1, INS, IGFBP3, IGF1, GH1, NR0B1
30	adenoma	22.0	PBX1, INS, IGFBP3, IGF1, GH1, NR0B1
31	thyroiditis	21.9	PBX1, LHX3, INS, IGFBP3, IGF1, GH1
32	neonatal thyrotoxicosis	13.6	LHX3, PROP1
33	growth hormone deficient dwarfism	13.6	GH1, POU1F1
34	tsh producing pituitary tumor	13.5	GH1, PRL
35	chromophobe adenoma	13.5	GH1, PRL
36	mccune albright syndrome	13.5	GH1, PRL
37	laron dwarfism	13.4	IGF1, GH1
38	prolactin producing pituitary tumor	13.4	PRL, POMC
39	insulin-like growth factor i deficiency	13.3	IGF1, GH1
40	marasmus	13.3	IGFBP3, GH1
41	obstructive hydrocephalus	13.3	IGF1, PRL
42	sexual disorder	13.3	INS, PRL
43	robinow syndrome	13.3	IGF1, GH1
44	fetal adenoma	13.3	GH1, PRL
45	adrenal gland hyperfunction	13.3	INS, PRL
46	hypothalamic disease	13.3	GH1, CRH, PRL
47	neurogenic diabetes insipidus	13.2	PRL, POMC
48	diffuse idiopathic skeletal hyperostosis	13.2	IGFBP3, IGF1
49	congenital hypothyroidism	13.2	IGF1, TSHB, POU1F1
50	cushing's syndrome	13.2	GH1, CRH, POMC

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to pituitary hormone deficiency:

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MGI Mouse Phenotypes related to pituitary hormone deficiency:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hearing/vestibular/ear phenotype	MP:0005377	8.8	HESX1, OTX2, IGF1, LHX3, PBX1, SOD1
2	endocrine/exocrine gland phenotype	MP:0005379	8.5	OTX2, LHX3, LHX4, NR5A1, HESX1, PROP1
3	respiratory system phenotype	MP:0005388	7.9	PROP1, HESX1, CRH, OTX2, TBCE, IGF1
4	growth/size phenotype	MP:0005378	7.3	INS, GH1, NR5A1, CRH, PROP1, SOX3
5	mortality/aging	MP:0010768	7.3	OTX2, PBX1, POU1F1, SOX3, PROP1, NR5A1
6	behavior/neurological phenotype	MP:0005386	7.2	POMC, PROP1, PBX1, TBCE, OTX2, NR5A1
7	nervous system phenotype	MP:0003631	6.3	CRH, HESX1, PRL, PROP1, SOX3, POU1F1
8	reproductive system phenotype	MP:0005389	6.1	LHX3, INS, IGF1, GH1, OTX2, NR0B1
9	homeostasis/metabolism phenotype	MP:0005376	5.0	NR5A1, CRH, PRL, PROP1, SOD1, SOX3

Articles related to pituitary hormone deficiency:

(show top 50)    (show all 90)

id	Title	Authors	Year	Affiliating Genes
1	A large deletion of PROP1 gene in patients with combi ned pituitary hormone deficiency from two unrelated Chinese pedigrees. (20395664)	Zhang H.... Shi D.	2010	PROP1
2	A novel mutation (V101A) of the LHX4 gene in a Japane se patient with combined pituitary hormone deficiency. (19856252)	Tajima T.... Fujieda K.	2010	LHX4
3	ANE syndrome caused by mutated RBM28 gene: a novel et iology of combined pituitary hormone deficiency. (20231366)	Spiegel R.... Tenenbaum-Rakover Y.	2010	RBM28
4	Molecular analysis of novel PROP1 mutations associated with combined pituitary hormone deficiency (CPHD). (19128366)	Kelberman D.... Dattani M.T.	2009	PROP1
5	A novel recessive splicing mutation in the POU1F1 gen e causing combined pituitary hormone deficiency. (19498317)	Carlomagno Y.... Giordano M.	2009	GH1, POU1F1
6	Sex steroid replacement for induction of puberty in multiple pituitary hormone deficiency. (19337185)	Walvoord E.	2009	PRL
7	A novel germline mutation, IVS4+1G>A, of the POU1F1 gene underlying combined pituitary hormone deficiency. (18059085)	Snabboon T.... Shotelersuk V.	2008	PRL, TSHB, GH1
8	Three novel missense mutations within the LHX4 gene are associated with variable pituitary hormone deficiencies. (18073311)	Pfaeffle R.W.... Rhodes S.J.	2008	LHX4
9	A novel dominant negative mutation of OTX2 associated with combined pituitary hormone deficiency. (18728160)	Diaczok D.... Radovick S.	2008	OTX2, LHX3, PROP1
10	Prevalence of GH and other anterior pituitary hormone deficiencies in adults with nonsecreting pituitary microadenomas and normal serum IGF-1 levels. (18221393)	Yuen K.C.... Friedman T.C.	2008	IGF1
11	Molecular analysis of PROP1, PIT1, HESX1, LHX3, and LHX4 shows high frequency of PROP1 mutations in patients with familial forms of combined pituitary hormone deficiency. (18157385)	Vieira T.C.... Abucham J.	2007	LHX3, PROP1, POU1F1
12	A novel missense mutation (P366T) of the LHX4 gene causes severe combined pituitary hormone deficiency with pituitary hypoplasia, ectopic posterior lobe and a poorly developed sella turcica. (17527005)	Tajima T.... Fujieda K.	2007	PBX1, GH1, LHX4
13	Long-term follow-up of combined pituitary hormone deficiency in two siblings with a Prophet of Pit-1 gene mutation. (17162714)	Georgopoulos N.A.... Panidis D.	2006	PRL, PROP1, POU1F1
14	Clinical case seminar: a novel LHX3 mutation presenting as combined pituitary hormonal deficiency. (16394081)	Bhangoo A.P.... Rhodes S.J.	2006	IGF1, IGFBP3, PRL
15	Identification and functional analysis of the novel S179R POU1F1 mutation associated with combined pituitary hormone deficiency. (16968807)	Miyata I.... Brue T.	2006	PRL, TSHB, GH1
16	Waxing and waning of a pituitary mass in a young woman with combined pituitary hormone deficiency (CPHD) due to a PROP-1 mutation. (16703408)	Nascif S.O.... Abucham J.	2006	PROP1
17	The natural history of the R120C PROP1 mutation reveals a wide phenotypic variability in two untreated adult brothers with combined pituitary hormone deficiency. (17526949)	Vieira T.C.... Abucham J.	2006	PROP1
18	Genetic screening of combined pituitary hormone deficiency: experience in 195 patients. (16735499)	Reynaud R.... Barlier A.	2006	LHX3, PROP1, POU1F1
19	Novel mutations within the POU1F1 gene associated with variable combined pituitary hormone deficiency. (15928241)	Turton J.P.... Dattani M.T.	2005	PRL, GH1, POU1F1
20	Mutation analysis of POUF-1, PROP-1 and HESX-1 show low frequency of mutations in children with sporadic forms of combined pituitary hormone deficiency and septo-optic dysplasia. (15670191)	Rainbow L.A.... Kirk J.M.	2005	SOD1, PROP1, POU1F1
21	Three novel mutations in POU1F1 in Israeli patients with combined pituitary hormone deficiency. (15844473)	Gat-Yablonski G.... Phillip M.	2005	PRL, POU1F1
22	A novel PROP1 gene mutation (157delA) in Japanese siblings with combined anterior pituitary hormone deficiency. (15521968)	Tatsumi K.I.... Amino N.	2004	PROP1
23	The de novo Q167K mutation in the POU1F1 gene leads to combined pituitary hormone deficiency in an Italian patient. (12904605)	Malvagia S.... Zammarchi E.	2003	PRL, GH1, POU1F1
24	Familial combined pituitary hormone deficiency due to a novel mutation R99Q in the hot spot region of Prophet of Pit-1 presenting as constitutional growth delay. (12519826)	Vieira T.C.... Abucham J.	2003	PROP1, POU1F1
25	New N-terminal located mutation (Q4ter) within the POU1F1-gene (PIT-1) causes recessive combined pituitary hormone deficiency and variable phenotype. (12932747)	Salemi S.... Mullis P.E.	2003	POU1F1
26	PROP-1 gene mutation (R120C) causing combined pituitary hormone deficiencies with variable clinical course in eight siblings of one Jewish Moroccan family. (14614227)	Lazar L.... Phillip M.	2003	PROP1
27	Growth without growth hormone: growth pattern and final height of five patients with idiopathic combined pituitary hormone deficiency. (12807508)	Lazar L.... Phillip M.	2003	IGF1, GH1
28	A novel mutation in PIT-1: phenotypic variability in familial combined pituitary hormone deficiencies. (11924936)	Gat-Yablonski G.... Phillip M.	2002	POU1F1
29	Adrenal hypoplasia congenita with multiple pituitary hormone deficiency without documented mutation in DAX1 or SF1 gene. (12083815)	Shalitin S.... Weintrob N.	2002	NR5A1, NR0B1
30	Familial combined pituitary hormone deficiency caused by PROP-1 gene mutation. Growth patterns and MRI studies in untreated subjects. (12006708)	Crone J.... Frisch H.	2002	PROP1, POU1F1
31	Adrenocorticotrope deficiency with clinical evidence for late onset in combined pituitary hormone deficiency caused by a homozygous 301-302delAG mutation of the PROP1 gene. (12812307)	Lamesch C.... Paschke R.	2002	POMC, PRL, GH1
32	LHX3 transcription factor mutations associated with combined pituitary hormone deficiency impair the activation of pituitary target genes. (11255008)	Sloop K.W.... Rhodes S.J.	2001	LHX3
33	Insufficient adrenarche in patients with combined pituitary hormone deficiency caused by a PROP-1 gene defect. (11592567)	Voutetakis A.... Dacou-Voutetakis C.	2001	CRH, PROP1
34	Combined pituitary hormone deficiency and pituitary hypoplasia due to a mutation of the Pit-1 gene. (10792348)	Frisch H.... PfAoffle R.	2000	POU1F1
35	Central hypocortisolism as part of combined pituitary hormone deficiency due to mutations of PROP-1 gene. (11022176)	Asteria C.... Beck-Peccoz P.	2000	POMC, PRL, INS
36	MR imaging of the pituitary gland in children and young adults with congenital combined pituitary hormone deficiency associated with PROP1 mutations. (10658742)	Fofanova O.... Yamashita S.	2000	PROP1, POU1F1
37	Cloning, characterization, and physical mapping of the canine Prop-1 gene (PROP1): exclusion as a candidate for combined pituitary hormone deficiency in German shepherd dogs. (10773688)	Lantinga-van Leeuwen I.S.... van Oost B.A.	2000	PROP1, POU1F1
38	Molecular analysis of LHX3 and PROP-1 in pituitary hormone deficiency patients with posterior pituitary ectopia. (10946868)	Sloop K.W.... Rhodes S.J.	2000	LHX3, PROP1
39	'Hot spot' in the PROP1 gene responsible for combined pituitary hormone deficiency. (10323394)	Deladoey J.... Mullis P.E.	1999	PROP1
40	Combined pituitary hormone deficiency in an inbred Brazilian kindred associated with a mutation in the PROP-1 gene. (10329025)	Nogueira C.R.... Kopp P.	1999	PROP1
41	Combined pituitary hormone deficiency: role of Pit-1 and Prop-1. (10626543)	Pfaffle R.W.... Kentrup H.	1999	PRL, PROP1, POU1F1
42	Mutations in PROP1 cause familial combined pituitary hormone deficiency. (9462743)	Wu W.... Rosenfeld M.G.	1998	PROP1, POU1F1
43	Compound heterozygous deletion of the PROP-1 gene in children with combined pituitary hormone deficiency. (9661653)	Fofanova O.... Yamashita S.	1998	PRL, PROP1, POU1F1
44	Rarity of PIT1 involvement in children from Russia with combined pituitary hormone deficiency. (9632165)	Fofanova O.V.... Yamashita S.	1998	PRL, POU1F1
45	A mutational hot spot in the Prop-1 gene in Russian children with combined pituitary hormone deficiency. (11081182)	Fofanova O.V.... Yamashita S.	1998	PRL, PROP1
46	Congenital multiple anterior pituitary hormone deficiencies. An approach of pituitary ontogenesis (9686002)	Brue T.... Enjalbert A.	1997	NR5A1, POU1F1
47	A new mutation of the gene encoding the transcription factor Pit-1 is responsible for combined pituitary hormone deficiency. (8768831)	Pellegrini-Bouiller I.... Enjalbert A.	1996	PRL, TSHB, GH1
48	A novel E250X mutation of the PIT1 gene in a patient with combined pituitary hormone deficiency. (7670563)	Irie Y.... Amino N.	1995	POU1F1
49	A 'hot spot' in the Pit-1 gene responsible for combined pituitary hormone deficiency: clinical and molecular correlates. (7852536)	Cohen L.E.... Radovick S.	1995	PRL, TSHB, GH1
50	Evaluation of adult idiopathic growth hormone deficiency with other pituitary hormones deficiency (2171885)	Gao T.S.... Gao S.M.	1990	POMC

Genes related to pituitary hormone deficiency according to GeneCards:

(show all 22)

id	Symbol	Description	Score	GeneCards Section Context
1	PROP1	PROP paired-like homeobox 1	11.1	Summaries, Publications
2	LHX3	LIM homeobox 3	11.1	Publications, Summaries
3	POU1F1	POU class 1 homeobox 1	11.1	Summaries, Publications
4	LHX4	LIM homeobox 4	11.1	Publications, Summaries
5	HESX1	HESX homeobox 1	11.1	Summaries, Publications
6	OTX2	orthodenticle homeobox 2	11.1	Summaries, Publications
7	TSHB	thyroid stimulating hormone, beta	11.0	Publications
8	SOX3	SRY (sex determining region Y)-box 3	11.0	Publications
9	RBM28	RNA binding motif protein 28	11.0	Publications
10	GH1	growth hormone 1	11.0	Publications
11	PRL	prolactin	11.0	Publications
12	CRH	corticotropin releasing hormone	11.0	Publications
13	POMC	proopiomelanocortin	11.0	Publications
14	IGFBP3	insulin-like growth factor binding protein 3	11.0	Publications
15	PBX1	pre-B-cell leukemia homeobox 1	11.0	Publications
16	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0	Publications
17	SOD1	superoxide dismutase 1, soluble	11.0	Publications
18	INS	insulin	11.0	Publications
19	PHF6	PHD finger protein 6	11.0	Publications
20	NR0B1	nuclear receptor subfamily 0, group B, member 1	11.0	Publications
21	NR5A1	nuclear receptor subfamily 5, group A, member 1	11.0	Publications
22	TBCE	tubulin folding cofactor E	11.0	Publications

Pathways related to pituitary hormone deficiency according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Glucocorticoid Pathway (HPA Axis), Pharmacodynamics34	9.9	CRH, POMC
2	Transcription Receptor-mediated HIF regulation10	9.4	INS, IGF1, IGFBP3
3	Transcription_Receptor-mediated HIF regulation41	9.3	IGF1, IGFBP3, INS
4	Development_Role of Activin A in cell differentiation and proliferation41	9.0	NR5A1, LHX3, PBX1
5	Transcription factors in neurogenesis10	9.0	SOX3, NR5A1, OTX2, PBX1
6	Development Role of Activin A in cell differentiation and proliferation10	8.8	NR5A1, LHX3, PBX1

Compounds related to pituitary hormone deficiency according to GeneDecks:

(show top 50)    (show all 92)

id	Compound	Score	Top Affiliating Genes
1	quinagolide32	9.9	IGF1, GH1, PRL
2	acth 1-2432	9.9	PRL, CRH, POMC
3	11 deoxycortisol32	9.7	PRL, POMC, CRH
4	fenfluramine32 9 9	11.7	POMC, PRL, IGFBP3, CRH
5	mecasermin32 9 9	11.6	INS, IGFBP3, IGF1
6	naloxone32 34 9 9	12.6	POMC, CRH, PRL, GH1
7	lanreotide32	9.6	IGFBP3, IGF1, GH1, PRL
8	cabergoline32 9 9	11.6	GH1, PRL, IGF1, IGFBP3
9	17-hydroxyprogesterone32 18	10.6	POMC, PRL, CRH, PBX1
10	carbamazepine32 34 9 9	12.5	CRH, PRL, POMC, IGFBP3
11	oxandrolone32 9 9	11.5	IGF1, IGFBP3, GH1, INS
12	pyridostigmine32 9 9	11.4	IGFBP3, IGF1, PRL, CRH, GH1
13	ptx132	9.4	POMC, POU1F1, NR5A1
14	megestrol acetate32	9.4	POMC, IGF1, IGFBP3
15	5-hydroxytryptophan32	9.4	PRL, GH1, CRH
16	opiate32	9.4	CRH, PRL, POMC, GH1
17	ghrp32	9.3	IGF1, IGFBP3, GH1, PRL, PBX1
18	l-nmma32	9.3	CRH, IGF1, SOD1, GH1
19	clonidine32 9 9	11.3	IGFBP3, PRL, POMC, GH1, IGF1
20	cortisone32 18	10.2	INS, GH1, POMC, CRH, IGF1
21	creatinine32	9.2	GH1, CRH, POMC, IGFBP3, IGF1
22	bromocriptine32 9 9	11.2	POU1F1, POMC, PRL, IGF1, IGFBP3, GH1
23	triiodothyronine32	9.1	IGF1, POMC, TSHB, IGFBP3, PRL, GH1
24	naltrexone32 34 9 9	12.1	IGF1, POMC, GH1, CRH, IGFBP3, PRL
25	metformin32 34 9 9	12.1	INS, IGF1, GH1, POMC
26	clomiphene citrate32	9.0	PRL, GH1, IGF1, CRH, IGFBP3, INS
27	epinephrine32 9 18 9	11.9	CRH, GH1, POMC, IGFBP3, INS, PRL
28	corticosterone32 18	9.9	PRL, CRH, GH1, NR5A1, POMC
29	estradiol32 9 18 9	11.8	PRL, POMC, PBX1, NR5A1, CRH
30	hexarelin32	8.8	CRH, POMC, PRL, PBX1, IGFBP3, IGF1
31	norepinephrine32 9 18 9	11.7	IGFBP3, POMC, CRH, INS, PRL, GH1
32	estrone32 9 18 9	11.7	NR5A1, GH1, IGFBP3, IGF1, PRL
33	octreotide32 42 9 9	11.7	CRH, POMC, PRL, GH1, IGF1, IGFBP3
34	hydrocortisone32 9 9	10.6	PBX1, CRH, IGF1, GH1, INS, PRL
35	glycerol32 9 18 9	11.6	INS, IGFBP3, GH1, NR0B1, POMC, CRH
36	vitamin d32	8.4	IGFBP3, CRH, IGF1, GH1, POU1F1, NR5A1
37	thyroxine32 18	9.4	INS, IGFBP3, IGF1, GH1, CRH, TSHB
38	androstenedione32 18	9.3	POMC, PBX1, INS, IGFBP3, IGF1, PRL
39	alanine32	8.1	POMC, POU1F1, INS, IGFBP3, SOX3, SOD1
40	testosterone32 9 18 9	11.1	PRL, NR5A1, PBX1, IGFBP3, NR0B1, PROP1
41	ribonucleic acid32	7.9	POU1F1, POMC, PRL, GH1, IGFBP3, IGF1
42	dhea32	7.8	POMC, PRL, CRH, GH1, IGF1, IGFBP3
43	arginine32	7.7	PBX1, INS, CRH, SOD1, IGF1, GH1
44	dehydroepiandrosterone sulfate32	7.5	POMC, PRL, PBX1, INS, IGFBP3, IGF1
45	dexamethasone32 42 34 9 9	11.4	NR0B1, CRH, PBX1, PRL, INS, POMC
46	progesterone32 42 9 18 9	11.1	IGF1, PBX1, IGFBP3, CRH, PRL, NR5A1
47	steroid32	6.9	PRL, PBX1, POU1F1, POMC, PROP1, IGFBP3
48	gnrh32	6.6	POMC, PROP1, HESX1, CRH, NR5A1, NR0B1
49	estrogen32	6.4	NR5A1, NR0B1, GH1, CRH, TSHB, PRL
50	acth32	6.1	POU1F1, PROP1, PRL, POMC, TSHB, INS

Cellular components related to pituitary hormone deficiency according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	insulin-like growth factor binding protein complex	GO:016942	9.5	IGFBP3, IGF1
2	extracellular space	GO:005615	8.1	IGFBP3, IGF1, GH1, CRH, SOD1, POMC
3	extracellular region	GO:005576	7.5	INS, POMC, SOD1, PRL, TSHB, CRH

Biological processes related to pituitary hormone deficiency according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	medial motor column neuron differentiation	GO:021526	10.2	LHX3, LHX4
2	positive regulation of insulin-like growth factor receptor signaling pathway	GO:043568	9.7	IGFBP3, IGF1, GH1
3	positive regulation of glycolysis	GO:045821	9.6	IGF1, INS
4	pituitary gland development	GO:021983	9.6	LHX3, NR0B1, SOX3
5	regulation of multicellular organism growth	GO:040014	9.5	SOD1, PRL, IGF1
6	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.4	GH1, IGF1, INS
7	positive regulation of MAPK cascade	GO:043410	9.2	IGF1, IGFBP3, INS
8	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.1	INS, IGF1, GH1
9	adrenal gland development	GO:030325	8.9	NR0B1, NR5A1, CRH
10	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.4	PROP1, POMC, POU1F1, NR5A1, IGF1, LHX3

Molecular functions related to pituitary hormone deficiency according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	prolactin receptor binding	GO:005148	9.7	PRL, GH1
2	sequence-specific DNA binding transcription factor activity	GO:003700	9.0	LHX3, LHX4, OTX2, HESX1, PROP1, POU1F1
3	hormone activity	GO:005179	8.3	CRH, PRL, GH1, IGF1, INS, POMC
4	sequence-specific DNA binding	GO:043565	7.6	LHX3, LHX4, OTX2, NR0B1, NR5A1, HESX1