MCID: PTT046
MIFTS: 54

Pituitary Hormone Deficiency, Combined, 2

Categories: Genetic diseases, Reproductive diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Pituitary Hormone Deficiency, Combined, 2

MalaCards integrated aliases for Pituitary Hormone Deficiency, Combined, 2:

Name: Pituitary Hormone Deficiency, Combined, 2 54 71 13
Panhypopituitarism 12 56 71 29 52 14 69
Pituitary Hormone Deficiency, Combined 2 29
Combined Pituitary Hormone Deficiency 42
Ateliotic Dwarfism with Hypogonadism 71
Pituitary Dwarfism Type 3 69
Panhypopituitarism Nos 12
Pituitary Dwarfism Iii 71
Simmond's Disease 12
Simmonds' Disease 12
Sheehan Syndrome 69
Hanhart Dwarfism 71
Cphd2 71

Characteristics:

Orphanet epidemiological data:

56
panhypopituitarism
Inheritance: Autosomal recessive,X-linked recessive;

OMIM:

54
Inheritance:
autosomal recessive


HPO:

32
pituitary hormone deficiency, combined, 2:
Inheritance autosomal recessive inheritance


Classifications:



Summaries for Pituitary Hormone Deficiency, Combined, 2

UniProtKB/Swiss-Prot : 71 Pituitary hormone deficiency, combined, 2: Combined pituitary hormone deficiency is defined as the impaired production of growth hormone and one or more of the other five anterior pituitary hormones. CPHD2 is characterized by pleiotropic deficiencies of growth hormone, thyroid-stimulating hormone, follicle- stimulating hormone, luteinizing hormone, prolactin and adrenocorticotropic hormone.

MalaCards based summary : Pituitary Hormone Deficiency, Combined, 2, also known as panhypopituitarism, is related to panhypopituitarism, x-linked and mental retardation, x-linked, with isolated growth hormone deficiency, and has symptoms including short stature, fatigue and hypoglycemia. An important gene associated with Pituitary Hormone Deficiency, Combined, 2 is PROP1 (PROP Paired-Like Homeobox 1), and among its related pathways/superpathways are Jak-STAT signaling pathway (KEGG) and G alpha (s) signalling events. The drugs Hormone Antagonists and Hormones have been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and testes, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Description from OMIM: 262600

Related Diseases for Pituitary Hormone Deficiency, Combined, 2

Diseases related to Pituitary Hormone Deficiency, Combined, 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 219)
id Related Disease Score Top Affiliating Genes
1 panhypopituitarism, x-linked 12.2
2 mental retardation, x-linked, with isolated growth hormone deficiency 11.5
3 combined pituitary hormone deficiency 11.4
4 sheehan syndrome 11.1
5 hypopituitarism 11.1
6 lhx3-related combined pituitary hormone deficiency 11.0
7 holoprosencephaly 9 10.8
8 bile acid synthesis defect, congenital, 2 10.8
9 rolandic epilepsy, mental retardation, and speech dyspraxia 10.6 HESX1 SOX3
10 potter's syndrome 10.6 LHX3 PROP1
11 african histoplasmosis 10.4 POMC PRL
12 prolactin producing pituitary tumor 10.4 IGF1 POMC
13 g6pc3 deficiency 10.4 GH1 PRL
14 lymphoepithelioma-like carcinoma 10.4 POMC PRL
15 olfactory nerve neoplasm 10.4 POMC PRL
16 osteoclast-like giant cell neoplasm of the pancreas 10.4 POMC PRL
17 vertebral artery occlusion 10.3 POMC PRL
18 acyl-coa dehydrogenase, short-chain, deficiency of 10.3 GHR IGF1
19 actinobacillosis 10.3 POMC PRL
20 lymphoma, gastric non hodgkins type 10.3 GH1 POMC
21 lipase deficiency, combined 10.2 GH1 IGF1
22 glassy cell carcinoma of the cervix 10.2 GH1 PRL
23 febrile infection-related epilepsy syndrome 10.2 IGF1 POMC
24 selenium poisoning 10.2 AVP IGF1
25 complement receptor deficiency 10.2 HESX1 LHX4 POU1F1 PROP1
26 simple cryoglobulinemia 10.2 GH1 GHR
27 cervical alveolar soft part sarcoma 10.2 AVP POMC
28 bagassosis 10.2 AVP POMC
29 epidural spinal canal angiolipoma 10.2 HESX1 LHX3 PROP1
30 diabetes insipidus 10.2
31 carotid artery thrombosis 10.1 AVP POMC
32 macular retinal edema 10.1 AVP POMC
33 hypodermyasis 10.1 GH1 POMC
34 ulcerative blepharitis 10.1 IGF1 POMC PRL
35 seminal vesicle chronic gonorrhea 10.1 AVP POMC
36 cardiovascular organ benign neoplasm 10.1 IGF1 POMC PRL
37 traumatic glaucoma 10.1 IGF1 POMC
38 vestibular gland benign neoplasm 10.0 IGF1 POMC PRL
39 epiphyseal chondrodysplasia, miura type 10.0 GHR IGF1
40 pelvic muscle wasting 10.0 IGF1 POMC PRL
41 male reproductive organ benign neoplasm 10.0 IGF1 POMC PRL
42 sphingolipidosis 10.0 POMC PRL
43 bronchiectasis 10.0 POMC PRL
44 survival motor neuron spinal muscular atrophy 10.0 IGF1 POMC PRL
45 pituitary adenoma, prolactin-secreting 10.0 GH1 IGF1 PRL
46 osseous heteroplasia, progressive 10.0 GH1 IGF1 PRL
47 worth's syndrome 10.0 GH1 IGF1 PRL
48 synovial chondromatosis 10.0 AVP POMC
49 aortic valve atresia 10.0 GH1 POMC PRL
50 adamantinous craniopharyngioma 10.0 IGF1 POU1F1 PRL PROP1

Comorbidity relations with Pituitary Hormone Deficiency, Combined, 2 via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Diabetes Insipidus Hypothyroidism
Premature Ovarian Failure 7

Graphical network of the top 20 diseases related to Pituitary Hormone Deficiency, Combined, 2:



Diseases related to Pituitary Hormone Deficiency, Combined, 2

Symptoms & Phenotypes for Pituitary Hormone Deficiency, Combined, 2

Symptoms via clinical synopsis from OMIM:

54

Endocrine Features:
hypogonadism
hypothyroidism
sequential loss of anterior pituitary tropic hormones
panhypopituitarism
hypoadrenalism

Growth- Height:
short stature (if untreated)

Metabolic Features:
neonatal hypoglycemia

Laboratory- Abnormalities:
low or absent growth hormone (gh)
low or absent thyroid-stimulating hormone (tsh)
low or absent luteinizing hormone (lh)
low or absent adrenocorticotropic hormone (acth)
low or absent follicle-stimulating hormone (fsh)
more
Neurologic- Central Nervous System:
hypoglycemic seizures


Clinical features from OMIM:

262600

Human phenotypes related to Pituitary Hormone Deficiency, Combined, 2:

56 32 (show all 34)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 short stature 56 32 Frequent (79-30%) HP:0004322
2 fatigue 56 32 frequent (33%) Frequent (79-30%) HP:0012378
3 hypoglycemia 56 32 frequent (33%) Frequent (79-30%) HP:0001943
4 amenorrhea 56 32 frequent (33%) Frequent (79-30%) HP:0000141
5 infertility 56 32 frequent (33%) Frequent (79-30%) HP:0000789
6 delayed puberty 56 32 occasional (7.5%) Occasional (29-5%) HP:0000823
7 osteopenia 56 32 occasional (7.5%) Occasional (29-5%) HP:0000938
8 constipation 56 32 occasional (7.5%) Occasional (29-5%) HP:0002019
9 delayed skeletal maturation 56 32 occasional (7.5%) Occasional (29-5%) HP:0002750
10 anterior pituitary hypoplasia 56 32 frequent (33%) Frequent (79-30%) HP:0010627
11 ectopic posterior pituitary 56 32 very rare (1%) Very rare (<4-1%) HP:0011755
12 hypotension 56 32 frequent (33%) Frequent (79-30%) HP:0002615
13 osteoporosis of vertebrae 56 32 occasional (7.5%) Occasional (29-5%) HP:0005625
14 decreased testicular size 56 32 frequent (33%) Frequent (79-30%) HP:0008734
15 depressed nasal ridge 56 32 frequent (33%) Frequent (79-30%) HP:0000457
16 pituitary dwarfism 56 32 occasional (7.5%) Occasional (29-5%) HP:0000839
17 hypogonadotrophic hypogonadism 56 32 frequent (33%) Frequent (79-30%) HP:0000044
18 absence of secondary sex characteristics 56 32 occasional (7.5%) Occasional (29-5%) HP:0008187
19 pituitary hypothyroidism 56 32 frequent (33%) Frequent (79-30%) HP:0008245
20 decreased circulating acth level 56 32 frequent (33%) Frequent (79-30%) HP:0002920
21 abnormality of secondary sexual hair 56 32 frequent (33%) Frequent (79-30%) HP:0009888
22 aplasia/hypoplasia of the breasts 56 32 frequent (33%) Frequent (79-30%) HP:0010311
23 abnormal prolactin level 56 32 frequent (33%) Frequent (79-30%) HP:0040086
24 ectopic anterior pituitary gland 56 32 very rare (1%) Very rare (<4-1%) HP:0012731
25 hypogonadism 32 HP:0000135
26 growth hormone deficiency 56 Frequent (79-30%)
27 hypothyroidism 32 HP:0000821
28 hypopituitarism 56 Obligate (100%)
29 hypoglycemic seizures 32 HP:0002173
30 neonatal hypoglycemia 32 HP:0001998
31 panhypopituitarism 32 HP:0000871
32 adrenal insufficiency 32 HP:0000846
33 growth delay 56 Frequent (79-30%)
34 prolactin deficiency 32 HP:0008202

MGI Mouse Phenotypes related to Pituitary Hormone Deficiency, Combined, 2:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.07 GHR HESX1 IGF1 LHX3 LHX4 POMC
2 growth/size/body region MP:0005378 9.97 HESX1 IGF1 LHX3 POMC POU1F1 PROP1
3 homeostasis/metabolism MP:0005376 9.96 AVP GHR IGF1 LHX3 LHX4 POMC
4 mortality/aging MP:0010768 9.85 AVP GHR HESX1 IGF1 LHX3 LHX4
5 nervous system MP:0003631 9.7 AVP GHR HESX1 IGF1 LHX3 LHX4
6 reproductive system MP:0005389 9.23 IGF1 LHX3 POU1F1 PRL PROP1 SOX3

Drugs & Therapeutics for Pituitary Hormone Deficiency, Combined, 2

Drugs for Pituitary Hormone Deficiency, Combined, 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormone Antagonists Phase 3,Phase 2
2 Hormones Phase 3,Phase 2
3 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
4 insulin Phase 3,Phase 2
5 Insulin, Globin Zinc Phase 3,Phase 2
6 Growth Hormone-Releasing Hormone Phase 3
7 arginine Nutraceutical Phase 3
8
Amitriptyline Approved Phase 2 50-48-6 2160
9
Fluoxetine Approved, Vet_approved Phase 2 54910-89-3 3386
10
Perphenazine Approved Phase 2 58-39-9 4748
11
Tramadol Approved, Investigational Phase 2 27203-92-5 33741
12 Adrenergic Agents Phase 2
13 Amitriptyline, perphenazine drug combination Phase 2
14 Analgesics Phase 2
15 Analgesics, Non-Narcotic Phase 2
16 Analgesics, Opioid Phase 2
17 Antidepressive Agents Phase 2
18 Antidepressive Agents, Second-Generation Phase 2
19 Antidepressive Agents, Tricyclic Phase 2
20 Antipsychotic Agents Phase 2
21 Central Nervous System Depressants Phase 2
22 Cytochrome P-450 CYP2D6 Inhibitors Phase 2
23 Cytochrome P-450 Enzyme Inhibitors Phase 2
24 Narcotics Phase 2
25 Neurotransmitter Agents Phase 2
26 Neurotransmitter Uptake Inhibitors Phase 2
27 Peripheral Nervous System Agents Phase 2
28 Psychotropic Drugs Phase 2
29
Serotonin Phase 2 50-67-9 5202
30 Serotonin Agents Phase 2
31 Serotonin Uptake Inhibitors Phase 2
32 Tranquilizing Agents Phase 2
33 Mitogens Phase 2
34
Hydrocortisone Approved, Vet_approved 50-23-7 5754 657311
35
Zinc Approved 7440-66-6 32051 23994
36
Butyric Acid Experimental 107-92-6 264
37 Anti-Inflammatory Agents
38 Cortisol succinate
39 Gastrointestinal Agents
40 glucagon
41 Glucagon-Like Peptide 1
42 Hydrocortisone 17-butyrate 21-propionate
43 Hydrocortisone acetate
44 Hydrocortisone-17-butyrate
45 Hypoglycemic Agents
46 Incretins
47 Vitamins

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Comparative Validation of the Growth Hormone Releasing Hormone and Arginine Test for the Diagnosis of Adult Growth Hormone Deficiency Completed NCT01060488 Phase 3
2 Growth Hormone as Add-on Treatment in Severe Fibromyalgia With Low IGF-1 Serum Levels (56 Characters) Completed NCT00497562 Phase 2 sc recombinant growth hormone + amitriptyline, fluoxetine and tramadol (treated group);amitriptyline, fluoxetine and tramadol alone (control group)
3 rhGH and rhIGF-1 Combination Therapy in Children With Short Stature Associated With IGF-1 Deficiency Terminated NCT00572156 Phase 2 NutropinAq® (Somatropin [rDNA origin]);Increlex® (Mecasermin [rDNA origin] injection) + NutropinAq® (Somatropin [rDNA origin]);Increlex® (Mecasermin [rDNA origin] injection) + NutropinAq® (Somatropin [rDNA origin]);Increlex® (Mecasermin [rDNA origin] injection) + NutropinAq® (Somatropin [rDNA origin])
4 Pegvisomant With Glucagon Test to Assess for Adult Growth Hormone Deficiency Unknown status NCT01804413 Pegvisomant;Regular insulin
5 Effect of Nutritional Formula Supplementation on Growth Rate of Growth Hormone (GH) Treated Children With Growth Hormone Deficiency (GHD) After the Second Year of Therapy Not yet recruiting NCT03053687

Search NIH Clinical Center for Pituitary Hormone Deficiency, Combined, 2

Cochrane evidence based reviews: combined pituitary hormone deficiency

Genetic Tests for Pituitary Hormone Deficiency, Combined, 2

Genetic tests related to Pituitary Hormone Deficiency, Combined, 2:

id Genetic test Affiliating Genes
1 Pituitary Hormone Deficiency, Combined 2 29
2 Panhypopituitarism 29

Anatomical Context for Pituitary Hormone Deficiency, Combined, 2

MalaCards organs/tissues related to Pituitary Hormone Deficiency, Combined, 2:

39
Pituitary, Thyroid, Testes

Publications for Pituitary Hormone Deficiency, Combined, 2

Variations for Pituitary Hormone Deficiency, Combined, 2

UniProtKB/Swiss-Prot genetic disease variations for Pituitary Hormone Deficiency, Combined, 2:

71
id Symbol AA change Variation ID SNP ID
1 PROP1 p.Arg73Cys VAR_003768 rs121917843
2 PROP1 p.Phe117Ile VAR_003769 rs121917840
3 PROP1 p.Arg120Cys VAR_003770 rs121917839
4 PROP1 p.Arg73His VAR_012746 rs121917842
5 PROP1 p.Arg125Trp VAR_054973 rs146918863
6 PROP1 p.Phe88Ser VAR_063235 rs121917841
7 PROP1 p.Arg99Gln VAR_063236 rs137853100

ClinVar genetic disease variations for Pituitary Hormone Deficiency, Combined, 2:

6 (show all 23)
id Gene Variation Type Significance SNP ID Assembly Location
1 PROP1 NM_006261.4(PROP1): c.358C> T (p.Arg120Cys) single nucleotide variant Pathogenic/Likely pathogenic rs121917839 GRCh37 Chromosome 5, 177420033: 177420033
2 PROP1 NM_006261.4(PROP1): c.349T> A (p.Phe117Ile) single nucleotide variant Pathogenic/Likely pathogenic rs121917840 GRCh37 Chromosome 5, 177420042: 177420042
3 PROP1 NM_006261.4(PROP1): c.150_151delAG (p.Gly52Glufs) deletion Pathogenic rs587776681 GRCh38 Chromosome 5, 177994297: 177994298
4 PROP1 NM_006261.4(PROP1): c.301_302delAG (p.Leu102Cysfs) deletion Pathogenic rs193922688 GRCh37 Chromosome 5, 177421147: 177421148
5 PROP1 NM_006261.4(PROP1): c.263T> C (p.Phe88Ser) single nucleotide variant Pathogenic rs121917841 GRCh37 Chromosome 5, 177421186: 177421186
6 PROP1 NM_006261.4(PROP1): c.112_124delTCGAGTGCTCCAC (p.Ser38Profs) deletion Pathogenic/Likely pathogenic rs587776682 GRCh38 Chromosome 5, 177994324: 177994336
7 PROP1 NM_006261.4(PROP1): c.150delA (p.Arg53Aspfs) deletion Pathogenic rs587776683 GRCh38 Chromosome 5, 177994298: 177994298
8 PROP1 NM_006261.4(PROP1): c.218G> A (p.Arg73His) single nucleotide variant Pathogenic rs121917842 GRCh37 Chromosome 5, 177421231: 177421231
9 PROP1 NM_006261.4(PROP1): c.217C> T (p.Arg73Cys) single nucleotide variant Pathogenic rs121917843 GRCh37 Chromosome 5, 177421232: 177421232
10 PROP1 NM_006261.4(PROP1): c.295C> T (p.Arg99Ter) single nucleotide variant Pathogenic rs121917844 GRCh37 Chromosome 5, 177421154: 177421154
11 PROP1 NM_006261.4(PROP1): c.296G> A (p.Arg99Gln) single nucleotide variant Pathogenic rs137853100 GRCh37 Chromosome 5, 177421153: 177421153
12 PROP1 NM_006261.4(PROP1): c.582G> A (p.Trp194Ter) single nucleotide variant Pathogenic/Likely pathogenic rs121917845 GRCh37 Chromosome 5, 177419809: 177419809
13 PROP1 NM_006261.4(PROP1): c.274C> T (p.Gln92Ter) single nucleotide variant Likely pathogenic rs794726693 GRCh38 Chromosome 5, 177994174: 177994174
14 PROP1 NM_006261.4(PROP1): c.334C> T (p.Arg112Ter) single nucleotide variant Likely pathogenic rs766673446 GRCh38 Chromosome 5, 177994114: 177994114
15 PROP1 NM_006261.4(PROP1): c.310delC (p.Arg104Glyfs) deletion Likely pathogenic rs786204663 GRCh38 Chromosome 5, 177994138: 177994138
16 46;X;t(X;5)(q24;q13)dn Translocation Pathogenic
17 PROP1 NM_006261.4(PROP1): c.557delC (p.Ala186Valfs) deletion Likely pathogenic rs762529663 GRCh38 Chromosome 5, 177992833: 177992833
18 PROP1 NM_006261.4(PROP1): c.390_391delAC (p.Leu131Alafs) deletion Likely pathogenic rs1057517027 GRCh37 Chromosome 5, 177420000: 177420001
19 PROP1 NM_006261.4(PROP1): c.343-2A> T single nucleotide variant Likely pathogenic rs1057517041 GRCh37 Chromosome 5, 177420050: 177420050
20 PROP1 NM_006261.4(PROP1): c.288_289delCT (p.Ile96Metfs) deletion Likely pathogenic rs1057516832 GRCh38 Chromosome 5, 177994159: 177994160
21 PROP1 NM_006261.4(PROP1): c.197dupC (p.His67Alafs) duplication Likely pathogenic rs1057517424 GRCh37 Chromosome 5, 177421252: 177421252
22 PROP1 NM_006261.4(PROP1): c.110-2A> G single nucleotide variant Likely pathogenic rs1057516846 GRCh38 Chromosome 5, 177994340: 177994340
23 PROP1 NM_006261.4(PROP1): c.3G> C (p.Met1Ile) single nucleotide variant Likely pathogenic rs1064797071 GRCh37 Chromosome 5, 177422932: 177422932

Expression for Pituitary Hormone Deficiency, Combined, 2

Search GEO for disease gene expression data for Pituitary Hormone Deficiency, Combined, 2.

Pathways for Pituitary Hormone Deficiency, Combined, 2

GO Terms for Pituitary Hormone Deficiency, Combined, 2

Cellular components related to Pituitary Hormone Deficiency, Combined, 2 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 AVP GH1 GHR IGF1 POMC TSHB
2 extracellular region GO:0005576 9.7 AVP GH1 GHR IGF1 POMC PRL
3 transcription factor complex GO:0005667 9.43 LHX3 POU1F1 PROP1
4 endosome lumen GO:0031904 8.96 GH1 PRL
5 growth hormone receptor complex GO:0070195 8.62 GH1 GHR

Biological processes related to Pituitary Hormone Deficiency, Combined, 2 according to GeneCards Suite gene sharing:

(show all 22)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.91 IGF1 LHX3 POMC POU1F1 PROP1
2 negative regulation of apoptotic process GO:0043066 9.83 AVP IGF1 LHX3 LHX4 PROP1
3 animal organ morphogenesis GO:0009887 9.73 LHX3 LHX4 PROP1
4 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.7 GH1 GHR IGF1
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.63 GH1 GHR IGF1
6 JAK-STAT cascade GO:0007259 9.61 GH1 GHR
7 hormone-mediated signaling pathway GO:0009755 9.6 GHR TSHB
8 ERK1 and ERK2 cascade GO:0070371 9.59 AVP IGF1
9 peptide hormone processing GO:0016486 9.58 POMC TSHB
10 motor neuron axon guidance GO:0008045 9.58 LHX3 LHX4
11 negative regulation of release of cytochrome c from mitochondria GO:0090201 9.57 AVP IGF1
12 insulin-like growth factor receptor signaling pathway GO:0048009 9.55 GHR IGF1
13 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.54 GH1 IGF1
14 positive regulation of multicellular organism growth GO:0040018 9.54 GH1 GHR POU1F1
15 adenohypophysis development GO:0021984 9.49 POU1F1 PROP1
16 growth hormone receptor signaling pathway GO:0060396 9.48 GH1 GHR
17 regulation of multicellular organism growth GO:0040014 9.43 GHR IGF1 PRL
18 somatotropin secreting cell differentiation GO:0060126 9.4 POU1F1 PROP1
19 positive regulation of JAK-STAT cascade GO:0046427 9.33 GH1 GHR PRL
20 medial motor column neuron differentiation GO:0021526 9.32 LHX3 LHX4
21 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.13 GH1 GHR PRL
22 pituitary gland development GO:0021983 8.92 HESX1 LHX3 POU1F1 SOX3

Molecular functions related to Pituitary Hormone Deficiency, Combined, 2 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.55 HESX1 LHX3 LHX4 POU1F1 PROP1
2 hormone activity GO:0005179 9.1 AVP GH1 IGF1 POMC PRL TSHB
3 neuropeptide hormone activity GO:0005184 8.96 AVP
4 prolactin receptor binding GO:0005148 8.96 GH1 PRL

Sources for Pituitary Hormone Deficiency, Combined, 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....