MCID: PTT001
MIFTS: 29

Pituitary Hypoplasia malady

Category: Endocrine diseases

Aliases & Classifications for Pituitary Hypoplasia

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Aliases & Descriptions for Pituitary Hypoplasia:

Name: Pituitary Hypoplasia 10 12
 
Hypoplasia of the Pituitary Gland 65

Classifications:



External Ids:

Disease Ontology10 DOID:7378
NCIt42 C27343
UMLS65 C0948740

Summaries for Pituitary Hypoplasia

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MalaCards based summary: Pituitary Hypoplasia, also known as hypoplasia of the pituitary gland, is related to septooptic dysplasia and holoprosencephaly-9. An important gene associated with Pituitary Hypoplasia is HESX1 (HESX Homeobox 1). Affiliated tissues include pituitary, cortex and heart, and related mouse phenotypes are hearing/vestibular/ear and craniofacial.

Related Diseases for Pituitary Hypoplasia

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Diseases related to Pituitary Hypoplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
idRelated DiseaseScoreTop Affiliating Genes
1septooptic dysplasia29.9HESX1, LHX3, POU1F1
2holoprosencephaly-910.3
3panhypopituitarism, x-linked10.3
4meningitis10.1
5anophthalmos with limb anomalies10.0HESX1, OTX2
6lung cancer9.9
7essential tremor9.9
8cartilage-hair hypoplasia9.9
9keratitis9.9
10lipoprotein glomerulopathy9.9
11premature ovarian failure9.9
12fragile x syndrome9.9
13behcet's disease9.9
14leukemia9.9
15lymphoblastic lymphoma9.9
16lymphoma9.9
17cystinosis9.9
18chlamydia9.9
19trachoma9.9
20arteriosclerosis9.9
21hemangiopericytoma9.9
22phimosis9.9
23monkeypox9.9
24cerebritis9.9
25choriocarcinoma9.9
26placental insufficiency9.9
27neuronitis9.9
28smallpox9.9
29cowpox9.9
30congenital human immunodeficiency virus9.9
31horseshoe kidney9.9
32pseudoangiomatous stromal hyperplasia9.9
33cardiomyopathy9.9
34cavernous malformation9.9
35tremor9.9
36meningococcal meningitis9.9
37epispadias9.9
38mesocardia9.8HESX1, LHX4, SOX3
39aortic valve atresia9.5HESX1, LHX4, OTX2, POU1F1
40eyelid disease9.5HESX1, LHX3, SOX3
41growth retardation alopecia pseudoanodontia optic9.5GHRHR, HESX1, SOX3
42acute myeloid leukemia, flt3-related9.5HESX1, LHX3, POU1F1
43inherited predisposition to essential thrombocythemia9.3HESX1, LHX3, LHX4, POU1F1
44complement component 8 deficiency9.3HESX1, LHX3, LHX4, POU1F1
45molybdenum cofactor deficiency b9.1HESX1, LHX3, LHX4, POU1F1, SOX3
46pituitary adenoma, growth hormone-secreting 29.0HESX1, LHX3, LHX4, POU1F1, SOX3
47strictly posterior acute myocardial infarction9.0HESX1, LHX3, LHX4, POU1F1, SOX3
48isolated levocardia8.9GHRHR, HESX1, LHX4, OTX2, POU1F1, SOX3
49female urethral cancer8.4GHRHR, HESX1, LHX3, LHX4, OTX2, POU1F1

Graphical network of the top 20 diseases related to Pituitary Hypoplasia:



Diseases related to pituitary hypoplasia

Symptoms for Pituitary Hypoplasia

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Drugs & Therapeutics for Pituitary Hypoplasia

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Drugs for Pituitary Hypoplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1HormonesPhase 411748
2
Ironapproved10217439-89-623925
Synonyms:
02583_FLUKA
12310_ALDRICH
12310_RIEDEL
129048-51-7
14067-02-8
161135-39-3
190454-13-8
195161-83-2
199281-22-6
209309_ALDRICH
209309_SIAL
255637_ALDRICH
266213_ALDRICH
266256_ALDRICH
267945_ALDRICH
267953_ALDRICH
26Fe
338141_ALDRICH
356808_ALDRICH
356824_ALDRICH
356832_ALDRICH
39344-71-3
3ZhP
413054_ALDRICH
443783-52-6
44890_ALDRICH
44890_FLUKA
675141-17-0
70884-35-4
73135-38-3
7439-89-6
8011-79-8
8053-60-9
AC1L2N38
ATW 230
ATW 432
Ancor B
Ancor en 80/150
Armco iron
Atomel 28
Atomel 300M200
Atomel 500M
Atomel 95
Atomiron 44MR
Atomiron 5M
Atomiron AFP 25
Atomiron AFP 5
C00023
C3518_SIAL
C3518_SIGMA
CCRIS 1580
CHEBI:18248
CID23925
Carbonyl iron
Copy Powder CS 105-175
D007501
DB01592
DSP 1000
DSP 128B
DSP 135
DSP 135C
DSP 138
Dexiron
Diseases (animal), iron overload
Diseases, iron overload
EF 1000
EF 250
EFV 200/300
EFV 250
EFV 250/400
EINECS 231-096-4
Ed-In-Sol
 
Eisen
F 60 (metal)
FE
FT 3 (element)
Fe
Fe-40
Fe1+
Feraheme
Feronate
Ferretts
Ferrlecit
Ferro-Caps
Ferro-Time
Ferrousal
Ferrovac E
Ferrum
GS 6
HF 2 (element)
HL (iron)
HQ (metal)
HS (iron)
HS 4849
HSDB 604
Hemocyte
Hierro
Hoeganaes ATW 230
Hoeganaes EH
IRMM524A_FLUKA
IRMM524B_FLUKA
IRON
Infufer
Iron
Iron (Fe)
Iron (Fe1+)
Iron ion (Fe+)
Iron ion(1+)
Iron monocation
Iron standard for AAS
Iron(1+)
Iron(1+) ion
Iron(III) nitrate solution
Iron, elemental
Iron, ion (Fe1+)
Iron, ion (Fe1+) (8CI,9CI)
LOHA
LS-3196
MolPort-003-925-001
NC 100
PZh-1M3
PZh-2
PZh1M1
PZh2M
PZh2M1
PZh2M2
PZh3
PZh3M
PZh4M
PZhO
Remko
SUY-B 2
Siderol
UNII-E1UOL152H7
Venofer
Vitedyn-Slo
Yieronia
fer
ferrous ascorbate
ferrous fumarate
ferrous gluconate
ferrous glycine sulfate
ferrous iron
ferrous succinate
ferrous sulfate
hierro
3Liver Extracts3572

Interventional clinical trials:

idNameStatusNCT IDPhase
1Endocrine Dysfunction and Growth Hormone Deficiency in Children With Optic Nerve HypoplasiaCompletedNCT00140413Phase 4
2Growth Arrest in Focal Dermal HypoplasiaActive, not recruitingNCT02463656
3Multi-Center Study of Iron Overload: Pilot StudyActive, not recruitingNCT01114776

Search NIH Clinical Center for Pituitary Hypoplasia

Genetic Tests for Pituitary Hypoplasia

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Anatomical Context for Pituitary Hypoplasia

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MalaCards organs/tissues related to Pituitary Hypoplasia:

33
Pituitary, Cortex, Heart, Colon, Lung, Breast, Liver

Animal Models for Pituitary Hypoplasia or affiliated genes

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MGI Mouse Phenotypes related to Pituitary Hypoplasia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.4HESX1, LHX3, OTX2, POU1F1
2MP:00053828.1HESX1, LHX3, OTX2, POU1F1, SOX3
3MP:00053897.9GHRHR, LHX3, OTX2, POU1F1, SOX3
4MP:00107687.5HESX1, LHX3, LHX4, OTX2, POU1F1, SOX3
5MP:00053767.2GHRHR, LHX3, LHX4, OTX2, POU1F1, SOX3
6MP:00053797.1GHRHR, HESX1, LHX3, LHX4, OTX2, POU1F1
7MP:00036316.9GHRHR, HESX1, LHX3, LHX4, OTX2, POU1F1
8MP:00053786.9GHRHR, HESX1, LHX3, OTX2, POU1F1, SOX3

Publications for Pituitary Hypoplasia

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Articles related to Pituitary Hypoplasia:

(show all 34)
idTitleAuthorsYear
1
Plasma clusterin as a candidate pre-diagnosis marker of colorectal cancer risk in the Florence cohort of the European Prospective Investigation into Cancer and Nutrition: a pilot study. (25884309)
2015
2
Prestroke Dementia: Characteristics and Clinical Features in Consecutive Series of Patients. (24401477)
2014
3
MicroRNA-195 inhibits non-small cell lung cancer cell proliferation, migration and invasion by targeting MYB. (24486218)
2014
4
Spontaneous Coronary Artery Dissection: Revascularization Versus Conservative Therapy. (25406203)
2014
5
Submucous uterine fibroid mimicking ruptured ectopic gestation: a case report. (25177608)
2014
6
CD22 monoclonal antibody therapies in relapsed/refractory acute lymphoblastic leukemia. (23633448)
2013
7
Vaccinations for healthcare personnel: update on influenza, hepatitis B, and pertussis. (23806899)
2013
8
Case-control studies on the relationship between onchocerciasis and epilepsy: systematic review and meta-analysis. (23556028)
2013
9
CYP2C19 polymorphisms and antiplatelet effects of clopidogrel in acute ischemic stroke in China. (23640828)
2013
10
Diet and carbohydrate food knowledge of multi-ethnic women: a comparative analysis of pregnant women with and without Gestational Diabetes Mellitus. (24069200)
2013
11
Pilot study of vapotherm oxygen delivery in moderately severe bronchiolitis. (22100741)
2012
12
Glycosphingolipid profile of the apical pole of human placental capillaries: the relevancy of the observed data to Fabry disease. (22319058)
2012
13
How Dravet syndrome became a model for studying childhood genetic epilepsies. (22843408)
2012
14
Management of noninfectious mixed cryoglobulinemia vasculitis: data from 242 cases included in the CryoVas survey. (22474249)
2012
15
The obesity gene and colorectal cancer risk: a population study in Northern Italy. (22153534)
2012
16
Incidence and predictors of congestive heart failure after autologous hematopoietic cell transplantation. (21976673)
2011
17
Drug-induced lichenoid dermatitis with histopathologic features of mycosis fungoides in a patient with psoriasis. (21084025)
2010
18
Endoplasmic reticulum chaperone protein GRP-78 mediates endocytosis of dentin matrix protein 1. (18757373)
2008
19
Chemically induced model of hypermethioninemia in rats. (16978704)
2007
20
Differential expression of genes in amyotrophic lateral sclerosis revealed by profiling the post mortem cortex. (17127558)
2006
21
Peutz-Jeghers Syndrome with multiple genital tract tumors and breast cancer: a case report with a review of literatures. (16891826)
2006
22
BDNF rescues myosin heavy chain IIB muscle fibers after neonatal nerve injury. (14973145)
2004
23
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties. (15454239)
2004
24
Gastric neurostimulation for gastroparesis: time to pick up the pace. (12949743)
2003
25
Clastogenic effects of streptozotocin on human colon cancer cell lines with gene amplification. (14669907)
2003
26
Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells. (11870500)
2002
27
Advances in the immunopathogenesis of pulmonary tuberculosis. (11371766)
2001
28
Cardiolipin provides specificity for targeting of tBid to mitochondria. (11025668)
2000
29
Molecular analysis of neisserial Opa protein interactions with the CEA family of receptors: identification of determinants contributing to the differential specificities of binding. (11207550)
1999
30
Cholesterol embolism: a fatal complication after thrombolytic therapy for acute myocardial infarction. (9679800)
1998
31
Comparison of sialic acids excretion in spot urines and 24-hour-urines of children and adults. (9156567)
1997
32
New autosomal-recessive syndrome of Leber congenital amaurosis, short stature, growth hormone insufficiency, mental retardation, hepatic dysfunction, and metabolic acidosis. (9268092)
1997
33
Two high-performance liquid chromatographic assays for the determination of free and total silibinin diastereomers in plasma using column switching with electrochemical detection and reversed-phase chromatography with ultraviolet detection. (8548017)
1995
34
Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with Ramsay Hunt syndrome: report of a case and review of the literature. (2543853)
1989

Variations for Pituitary Hypoplasia

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Expression for genes affiliated with Pituitary Hypoplasia

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Search GEO for disease gene expression data for Pituitary Hypoplasia.

Pathways for genes affiliated with Pituitary Hypoplasia

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GO Terms for genes affiliated with Pituitary Hypoplasia

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Biological processes related to Pituitary Hypoplasia according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1motor neuron axon guidanceGO:000804510.1LHX3, LHX4
2pituitary gland developmentGO:002198310.1LHX3, SOX3
3organ morphogenesisGO:00098879.9LHX3, LHX4
4somatotropin secreting cell developmentGO:00601339.8GHRHR, POU1F1
5determination of adult lifespanGO:00083409.6GHRHR, POU1F1
6positive regulation of multicellular organism growthGO:00400189.6GHRHR, POU1F1
7positive regulation of transcription, DNA-templatedGO:00458939.2LHX3, OTX2, POU1F1
8transcription, DNA-templatedGO:00063519.1LHX3, LHX4, SOX3
9positive regulation of transcription from RNA polymerase II promoterGO:00459448.5LHX3, OTX2, POU1F1

Sources for Pituitary Hypoplasia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet