Pituitary Tumor malady

MedlinePlus: Your pituitary gland is a pea-sized gland at the base of your brain. the pituitary is the "master control gland" - it makes hormones that affect growth and the functions of other glands in the body. pituitary tumors are fairly common. about 1 in 10,000 people get them. they grow slowly, do not spread and are usually not cancerous. the most common type of pituitary tumor produces hormones and disrupts the balance of hormones in your body. this can cause endocrine diseases such as cushing's syndrome and hyperthyroidism. symptoms of pituitary tumors include headaches vision problems nausea and vomiting any of the problems caused by the production of too many hormones pituitary tumors are usually curable. treatment is often surgery to remove the tumor. other options include medicines and radiation.²³

MalaCards: Pituitary Tumor, also known as pituitary tumors, is related to prolactin producing pituitary tumor and thyroid cancer. An important gene associated with Pituitary Tumor is PTTG1IP (pituitary tumor-transforming 1 interacting protein), and among its related pathways are Neuroactive ligand-receptor interaction and CREB Pathway. The drugs octreotide acetate and octreotide and the compounds glucose and levodopa have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and liver, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

NINDS: The pituitary is a small, bean-sized gland that is below the hypothalamus, a structure at the base of the brain, by a thread-like stalk that contains both blood vessels and nerves.³¹

Wikipedia: Pituitary adenomas are noncancerous tumors that occur in the pituitary gland. Pituitary adenomas are...⁴⁴ more...

pituitary tumor 7 pituitary tumors 31 32 23

pituitary neoplasms 43

Diseases related to pituitary tumor by text searches and GeneDecks gene sharing:

(show top 50)    (show all 914)

id	Related Disease	Score	Top Affiliating Genes
1	prolactin producing pituitary tumor	33.8	AIP, TRH, SST, PRL, POMC
2	thyroid cancer	31.8	RET, LGALS3, APC, CALCA, DYT10, PPARG
3	hormone producing pituitary cancer	31.8	RAB18, CDK2AP2, ARG2, IGF1, AIP, SST
4	prolactinoma	31.8	NCAM1, VIP, MYC, BMP2, LIF, PBX1
5	multiple endocrine neoplasia	30.6	RET, CNC, VIP, PBX1, CHGB, CHGA
6	acromegaly	30.5	CNC, VIP, VEGFA, RAB18, PBX1, SCG5
7	somatotrophinoma	29.7	RB1, CDKN2A, MEN1, APC, IGF1, GNAS
8	squamous cell carcinoma	29.7	LGALS3, MKI67, CCND1, CYP2D6, EGF, EGFR
9	growth hormone secreting pituitary adenoma	29.7	RB1, VEGFA, CGA, MEN1, IGF1, GNAS
10	carney complex	29.7	NCAM1, NCOA2, CNC, CHGA, CDKN1B, CDK2AP2
11	nelson syndrome	29.6	MGMT, PTTG1, SST, PPARG, CRH, PRL
12	pituitary gland disease	29.4	CGA, IGF1, GH1, PRL
13	pituitary apoplexy	28.8	INS, GNRH1, GH1, TRH, PRL, POMC
14	diabetes insipidus	28.6	LNPEP, SCG5, CGA, AVPR1B, INS, IGF1
15	pituitary carcinoma	28.5	PCNA, LGALS3, CHGA, MIR122, MIR493, MGMT
16	hypothyroidism	28.5	RET, LGALS3, CGA, FSHR, CALCA, TRH
17	empty sella syndrome	28.5	INS, IGFBP3, TRH, PRL, POMC
18	hyperthyroidism	28.3	PCSK2, PCSK1, CHGA, CGA, CGB7, FSHR
19	t-cell leukemia	28.3	CNTN2, MYC, BIRC5, LGALS3, FOS, CCND2
20	gigantism	28.2	CDKN2A, INS, MEN1, IL6, IGFBP3, IGF1
21	pituitary adenoma	27.8	NCAM1, RET, CNC, PCSK2, PCNA, PCSK1
22	hyperprolactinemia	27.0	VIP, CGA, INS, IL6, IGFBP3, IGF1
23	hypogonadism	26.7	PCSK1, RAB18, PBX1, LEPR, CGA, FSHB
24	pancreatic cancer	26.7	RET, VIP, VEGFA, BIRC5, KDR, LGALS3
25	craniopharyngioma	26.6	PCNA, LGALS3, CGA, MKI67, INS, IL6
26	colorectal cancer	26.5	GSTM1, GSTT1, APC, CCND1, TP53, TNF
27	growth hormone deficiency	26.3	VIP, PBX1, LEPR, MMP2, MMP9, INS
28	breast cancer	25.7	PIK3CA, NCOA2, SFRP2, MYC, AURKA, CDKN1B
29	testicular cancer	25.6	CGA, FSHR, CDKN1A, CDKN1B, MMP2, MMP9
30	myxoma	25.6	CNC, VEGFA, BIRC5, MMP2, MMP9, IL6
31	human t-cell leukemia virus type 1	24.8	CNTN2, RB1, MYC, LIF, BIRC5, JAK2
32	non-small cell lung carcinoma	24.1	NCAM1, PCNA, RB1, VEGFA, MYC, BMP2
33	adenoma	23.5	PIK3CA, NCAM1, NCOA2, NCOR2, RET, CNC
34	squamous cell carcinoma of the head and neck	21.7	PIK3CA, NCAM1, PCNA, VEGFA, MYC, PARP1
35	thyroiditis	21.7	PIK3CA, PIK3R1, NCAM1, NCOA2, NCOR2, RET
36	lung carcinoma	21.3	PIK3CA, PIK3R1, NCAM1, PCNA, RB1, VEGFA
37	carcinoma	20.5	PIK3CA, PIK3R1, NCAM1, NCOA2, NCOR2, RET
38	leiomyoma	20.4	PIK3R1, PCNA, VEGFA, MYC, BMP2, LIF
39	esophagitis	20.2	PIK3CA, NCAM1, RET, SFRP2, SFRP4, PCNA
40	esophageal squamous cell carcinoma	19.9	PIK3CA, NCAM1, PCNA, RB1, VEGFA, MYC
41	multiple myeloma	19.6	PIK3CA, PIK3R1, NCAM1, NCOR2, SFRP2, SFRP4
42	esophageal cancer	19.5	PIK3CA, PCNA, RB1, VEGFA, MYC, BIRC5
43	endometrial carcinoma	19.3	PIK3CA, NCOR2, PCNA, RB1, VEGFA, LNPEP
44	hepatitis b	18.8	PIK3CA, PIK3R1, CNTN2, PCNA, RB1, VIP
45	retinoblastoma	18.8	PIK3CA, PIK3R1, NCAM1, SFRP2, PCNA, RB1
46	retinitis	18.5	PIK3CA, SFRP2, PCNA, RB1, VIP, VEGFA
47	endometrial cancer	18.4	PIK3CA, PIK3R1, RET, SFRP4, PCNA, RB1
48	astrocytoma	18.4	PIK3CA, PIK3R1, NCAM1, RET, PCNA, RB1
49	myeloma	18.3	PIK3CA, PIK3R1, NCAM1, NCOR2, CNTN2, SFRP2
50	hepatocellular carcinoma	17.2	PIK3CA, PIK3R1, NCAM1, RET, CNC, SFRP2

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 octreotide, octreotide acetate

MalaCards organs/tissues related to pituitary tumor:

²²

MGI Mouse Phenotypes related to pituitary tumor:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.9	NCOA2, RET, SFRP2, PCSK2, PCSK1, SCG5
2	respiratory system phenotype	MP:0005388	10.7	RET, SFRP4, LIF, SCG5, LEPR, FST
3	craniofacial phenotype	MP:0005382	10.5	NCOR2, PBX1, FST, INSM1, MEN1, GNAS
4	hematopoietic system phenotype	MP:0005397	9.8	PCNA, PCSK1, LGALS3, FSHR, CDKN1A, FGF2
5	other phenotype	MP:0005395	9.2	PBX1, KDR, LEPR, FSHR, JAK2, CDKN2A
6	limbs/digits/tail phenotype	MP:0005371	9.0	RET, SFRP2, RB1, VEGFA, BMP2, PBX1
7	pigmentation phenotype	MP:0001186	8.8	RB1, MYC, CDKN1B, CDKN2A, APC, CASR
8	normal phenotype	MP:0002873	8.6	PIK3R1, RET, SFRP2, VIP, VEGFA, MYC
9	reproductive system phenotype	MP:0005389	8.5	PIK3CA, NCOA2, RET, SFRP2, SFRP4, PCSK2
10	hearing/vestibular/ear phenotype	MP:0005377	8.5	RB1, MYC, BMP2, PBX1, PARP1, CDKN1A
11	embryogenesis phenotype	MP:0005380	8.4	PIK3CA, NCOA2, RET, SFRP2, MYC, BIRC5
12	renal/urinary system phenotype	MP:0005367	8.1	RET, SFRP4, PBX1, LEPR, CHGA, CDKN1A
13	nervous system phenotype	MP:0003631	7.8	CNTN2, SFRP2, RB1, MYC, BMP2, LIF
14	liver/biliary system phenotype	MP:0005370	7.8	NCOR2, VEGFA, LIF, PBX1, SCG5, IRS1
15	integument phenotype	MP:0010771	7.8	NCOA2, PCSK2, RB1, MYC, LIF, PBX1
16	immune system phenotype	MP:0005387	7.6	NCOA2, PCSK1, PBX1, KDR, SCG5, LGALS3
17	no phenotypic analysis	MP:0003012	7.3	PIK3R1, NCOA2, RET, SFRP2, PCNA, RB1
18	behavior/neurological phenotype	MP:0005386	7.0	PIK3CA, NCAM1, NCOA2, NCOR2, CNTN2, PCSK2
19	digestive/alimentary phenotype	MP:0005381	6.9	NCOR2, RET, SFRP4, PCSK1, RB1, VEGFA
20	mortality/aging	MP:0010768	6.7	PIK3CA, NCAM1, NCOR2, RET, SFRP2, SFRP4
21	adipose tissue phenotype	MP:0005375	6.5	PIK3CA, PIK3R1, NCOR2, PCSK1, RB1, MYC
22	growth/size phenotype	MP:0005378	5.5	PIK3CA, PIK3R1, NCOA2, NCOR2, RET, SFRP2
23	tumorigenesis	MP:0002006	4.8	PIK3CA, PIK3R1, RET, RB1, MYC, LEPR
24	skeleton phenotype	MP:0005390	4.7	RB1, VEGFA, MYC, BMP2, LIF, PBX1
25	muscle phenotype	MP:0005369	4.5	PIK3CA, PIK3R1, RET, SFRP2, PCSK1, RB1
26	cardiovascular system phenotype	MP:0005385	4.3	PIK3CA, PIK3R1, NCOR2, RET, SFRP2, SFRP4
27	vision/eye phenotype	MP:0005391	3.9	PIK3CA, NCAM1, RB1, VEGFA, LIF, KDR
28	cellular phenotype	MP:0005384	3.1	PIK3CA, PIK3R1, NCAM1, NCOR2, RET, SFRP2
29	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3CA, PIK3R1, NCOR2, RET, SFRP2, SFRP4

Articles related to pituitary tumor:

(show top 50)    (show all 286)

id	Title	Authors	Year	Affiliating Genes
1	Overexpression of the pituitary tumor transforming ge ne induces p53-dependent senescence through activating DNA damage response path way in normal human fibroblasts. (20452981)	Hsu Y.H.... Lin J.J.	2010	TP53, PTTG1
2	RUNX1 and RUNX2 upregulate Galectin-3 expression in human pituitary tumors. (19020999)	Zhang H.Y.... Lloyd R.V.	2009	LGALS3, RUNX2, RUNX1
3	E2F1 induces pituitary tumor transforming gene (PTTG1 ) expression in human pituitary tumors. (19837943)	Zhou C.... Melmed S.	2009	E2F1, PTTG1
4	Potential bias in testing for hyperprolactinemia and pituitary tumors in risperidone-treated patients: a claims-based study. (19210771)	Gianfrancesco F.D.... Wang R.H.	2009	PRL
5	Oct-1 induces pituitary tumor transforming gene expression in endocrine tumors. (18550719)	Zhou C.... Melmed S.	2008	POU2F1, PTTG1
6	Effects of somatostatin on vascular endothelial growth factor (VEGF) secretion from non-functioning pituitary tumoral cells incubated in vitro. (18283262)	A8awnicka H.... Pawlikowski M.	2008	SST
7	Pituitary tumor type affects the chance of biochemical remission after radiosurgery of hormone-secreting pituitary adenomas. (18824993)	Pollock B.E.... Young W.F.	2008	POMC
8	Phosphatase and tensin homologue and pituitary tumor-transforming gene in pituitary adenomas. Clinical-pathologic and immunohistochemical analysis. (18620995)	Tena-Suck M.L.... de la Vega H.A.	2008	PTEN, PCNA, PTTG1
9	In vitro testing of new somatostatin analogs on pituitary tumor cells. (18243520)	Zatelli M.C.... degli Uberti E.C.	2008	SST
10	Pituitary tumor transforming gene interacts with Sp1 to modulate G1/S cell phase transition. (17353909)	Tong Y.... Melmed S.	2007	PTTG1
11	Targeting pituitary tumors. (18174730)	Heaney A.P.	2007	ESR1, NR1H2
12	Pituitary tumor enlargement in two patients with acromegaly during pegvisomant therapy. (17534717)	Frohman L.A.... Bonert V.	2007	IGF1, GHR, SST
13	Prognostic significance of human pituitary tumor-transforming gene immunohistochemical expression in differentiated thyroid cancer. (16418208)	Saez C.... Japon M.A.	2006	PTTG1
14	Immunohistochemical detection of angiotensin receptors AT1 and AT2 in normal rat pituitary gland, estrogen-induced rat pituitary tumor and human pituitary adenomas. (16977796)	Pawlikowski M.	2006	AGTR2
15	Genetics and proteomics of pituitary tumors. (16311409)	Asa S.L.... Ezzat S.	2005	FGFR4, GNAS
16	Expression and functional analysis of pituitary tumor transforming gene-1 [corrected] in uterine leiomyomas. (15769981)	Tsai S.J.... Wing L.Y.	2005	FGF2, PCNA, PTTG1
17	Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors. (15644399)	Zhao J.... Klibanski A.	2005	MEG3
18	Overexpression of human pituitary tumor transforming gene (hPTTG), is regulated by beta-catenin /TCF pathway in human esophageal squamous cell carcinoma. (15514942)	Zhou C.... Xu N.	2005	CTNNB1, TCF7L2, HNF4A
19	Expression of pituitary tumor transforming gene (PTTG) and its binding protein in human astrocytes and astrocytoma cells: function and regulation of PTTG in U87 astrocytoma cells. (15178645)	Tfelt-Hansen J.... Chattopadhyay N.	2004	PPARG, TNF, PTTG1
20	Pituitary tumor endocrinopathies and their endocrine evaluation. (12690978)	Simard M.F.	2003	PRL
21	Genetics of pituitary tumors: Focus on G-protein mutations. (14530508)	Lania A.... Spada A.	2003	GNAS
22	Vascular endothelial growth factor, its receptor KDR/Flk-1, and pituitary tumor transforming gene in pituitary tumors. (12213878)	McCabe C.J.... Gittoes N.J.	2002	KDR, FGF2, VEGFA
23	Oncogene activation in pituitary tumors. (11414475)	Yu R.... Melmed S.	2001	PTTG1
24	Expression of 11 beta-hydroxysteroid dehydrogenase isoenzymes in the human pituitary: induction of the type 2 enzyme in corticotropinomas and other pituitary tumors. (11397878)	Korbonits M.... Stewart P.M.	2001	HSD11B1, HSD11B2
25	Somatic mutation of TRbeta can cause a defect in negative regulation of TSH in a TSH-secreting pituitary tumor. (11701737)	Ando S.... Yen P.M.	2001	TXNRD2, TSHB
26	Pituitary tumor transforming gene (PTTG) regulates placental JEG-3 cell division and survival: evidence from live cell imaging. (10935539)	Yu R.... Melmed S.	2000	PTTG1
27	Pituitary tumor cosecreting thyrotropin and prolactin causing hyperthyroidism--a case report. (10933752)	Song Y.M.... Sheu W.H.	2000	PRL
28	Pituitary tumor registry: a novel clinical resource. (10634382)	Drange M.R.... Melmed S.	2000	PRL
29	Overexpression of vascular endothelial growth factor164 and its co-receptor neuropilin-1 in estrogen-induced rat pituitary tumors and GH3 rat pituitary tumor cells. (10639567)	Banerjee S.K.... Campbell D.R.	2000	NRP1, PRL
30	Clinical review 110: Diagnosis and treatment of pituitary tumors. (10566620)	Freda P.U.... Wardlaw S.L.	1999	IGF1, SST, GH1
31	Growth factors in pituitary tumors. (11081193)	Missale C.... Spano P.	1999	NGF
32	Diagnosis, treatment, and outcome of pituitary tumors and other abnormal intrasellar masses. Retrospective analysis of 353 patients. (10424206)	Gsponer J.... Gomez F.	1999	PRL
33	Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas. (10022450)	Zhang X.... Melmed S.	1999	PTTG1
34	Rapid actions of estrogens in GH3/B6 pituitary tumor cells via a plasma membrane version of estrogen receptor-alpha. (10323667)	Watson C.S.... Gametchu B.	1999	PRL
35	Galanin in normal and hyperplastic anterior pituitary cells. From pituitary tumor cell lines to transgenic mice. (9928158)	Hyde J.F.... Cai A.	1998	GAL
36	A kindred with a variant of multiple endocrine neoplasia type 1 demonstrating frequent expression of pituitary tumors but not linked to the multiple endocrine neoplasia type 1 locus at chromosome region 11q13. (9024241)	Stock J.L.... Aronin N.	1997	IGFBP3
37	Somatostatin receptor (SSTR) subtype-selective analogues differentially suppress in vitro growth hormone and prolactin in human pituitary adenomas. Novel potential therapy for functional pituitary tumors. (9410919)	Shimon I.... Melmed S.	1997	SSTR2, PRL, SSTR5
38	Results of somatostatin receptor scintigraphy do not predict pituitary tumor volume- and hormone-response to ocreotide therapy and do not correlate with tumor histology. (9150695)	PlAPckinger U.... Quabbe H.J.	1997	SST
39	GS protein mutations and pituitary tumors: functional correlates and possible therapeutic implications. (8769403)	Faglia G.... Spada A.	1996	GNAS
40	Gs protein mutations and the pathogenesis and function of pituitary tumors. (8769404)	Harris P.E.	1996	APC, GNAS
41	Purine-binding factor (nm23) gene expression in pituitary tumors: marker of adenoma invasiveness. (7745027)	Takino H.... Melmed S.	1995	NME1
42	Expression of epidermal growth factor (EGF), its receptor, and related oncoprotein (erbB-2) in human pituitary tumors and response to EGF in vitro. (7956924)	Chaidarun S.S.... Stewart P.M.	1994	EGFR, EGF, CGA
43	Etiopathogenesis of pituitary tumors (7802423)	Morange-Ramos I.... Jaquet P.	1994	DRD2
44	Activating mutations of the Gs alpha-gene in nonfunctioning pituitary tumors. (8396579)	Tordjman K.... Friedman E.	1993	GNAS
45	G-proteins and hormonal signalling in human pituitary tumors: genetic mutations and functional alterations. (8102338)	Spada A.... Faglia G.	1993	APC
46	Prolactin presents in all pituitary tumors of acromegalic patients. (8418010)	Furuhata S.... Toya S.	1993	PRL
47	The estrogenic and antiestrogenic properties of tamox ifen in GH4C1 pituitary tumor cells are gene specific. (1584221)	Shull J.D.... Hrbek M.J.	1992	PRL
48	Effect of long-term treatment with somatostatin analogue (SMS 201-995) on pituitary tumor shrinkage in acromegaly--report of two cases. (1378566)	Mukada K.... Ohta M.	1992	SST
49	Pituitary tumors: diagnosis and treatment. (1288725)	Croughs R.J.	1992	POMC, SST
50	Disappearance of a pituitary tumor after 15 months of treatment with CV 205-502, a new dopamine agonist. (1350936)	Fassbender W.J.... Federlin K.	1992	PRL

Genes related to pituitary tumor according to GeneCards:

(show top 50)    (show all 197)

id	Symbol	Description	Score	GeneCards Section Context
1	PTTG1IP	pituitary tumor-transforming 1 interacting protein	11.1	Orthologs, Summaries, Proteins, Aliases & Descriptions (show all 6 sections) Publications, Transcripts
2	PTTG1	pituitary tumor-transforming 1	11.1	Orthologs, Functions, Aliases & Descriptions, Transcripts (show all 5 sections) Publications
3	GNAS	GNAS complex locus	11.1	Publications, Summaries
4	PTTG3P	pituitary tumor-transforming 3, pseudogene	11.1	Aliases & Descriptions, Publications, Proteins
5	PTTG2	pituitary tumor-transforming 2	11.1	Aliases & Descriptions, Functions, Publications, Transcripts (show all 5 sections) Orthologs
6	ACVR1B	activin A receptor, type IB	11.0	Publications, Summaries
7	LOC100127954	pituitary tumor-transforming 1 pseudogene	11.0	Aliases & Descriptions
8	PTTG4P	pituitary tumor-transforming 4 pseudogene	11.0	Aliases & Descriptions
9	RHBDD3	rhomboid domain containing 3	11.0	Aliases & Descriptions, Publications
10	SST	somatostatin	11.0	Publications
11	PRL	prolactin	11.0	Publications
12	AIP	aryl hydrocarbon receptor interacting protein	11.0
13	POMC	proopiomelanocortin	11.0	Publications
14	PRKCA	protein kinase C, alpha	11.0	Publications
15	TSHB	thyroid stimulating hormone, beta	11.0	Publications
16	GH1	growth hormone 1	11.0	Publications
17	PCSK1	proprotein convertase subtilisin/kexin type 1	11.0
18	TRH	thyrotropin-releasing hormone	11.0
19	APC	adenomatous polyposis coli	11.0	Publications
20	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0	Publications
21	DPF2	D4, zinc and double PHD fingers family 2	11.0	Summaries
22	CNC	Carney complex, multiple neoplasia and lentiginosis	11.0	Publications
23	INSM1	insulinoma-associated 1	11.0	Expressions
24	PROP1	PROP paired-like homeobox 1	11.0	Functions, Publications
25	SSTR1	somatostatin receptor 1	11.0	Publications
26	SSTR4	somatostatin receptor 4	11.0	Publications
27	RAB18	RAB18, member RAS oncogene family	11.0	Publications
28	POU1F1	POU class 1 homeobox 1	11.0	Publications
29	FSHB	follicle stimulating hormone, beta polypeptide	11.0	Publications
30	FGF4	fibroblast growth factor 4	11.0	Publications
31	GH2	growth hormone 2	11.0
32	MEN1	multiple endocrine neoplasia I	11.0	Publications
33	TRHR	thyrotropin-releasing hormone receptor	11.0	Publications
34	SSTR5	somatostatin receptor 5	11.0	Publications
35	CGB7	chorionic gonadotropin, beta polypeptide 7	11.0	Publications
36	CHGB	chromogranin B (secretogranin 1)	11.0
37	SSTR3	somatostatin receptor 3	11.0
38	GHRHR	growth hormone releasing hormone receptor	11.0	Publications
39	FGFR4	fibroblast growth factor receptor 4	11.0	Publications
40	SSTR2	somatostatin receptor 2	11.0	Publications
41	TXNRD2	thioredoxin reductase 2	11.0	Publications
42	IKZF1	IKAROS family zinc finger 1 (Ikaros)	11.0	Publications
43	FST	follistatin	11.0	Publications
44	ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	11.0	Publications
45	GHSR	growth hormone secretagogue receptor	11.0	Publications
46	GHRH	growth hormone releasing hormone	11.0
47	GNRHR	gonadotropin-releasing hormone receptor	11.0	Publications
48	IFI27	interferon, alpha-inducible protein 27	11.0	Publications
49	TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	11.0	Publications
50	HSD11B2	hydroxysteroid (11-beta) dehydrogenase 2	11.0	Publications

Pathways related to pituitary tumor according to GeneDecks:

(show top 50)    (show all 228)

id	Pathway	Score	Top Affiliating Genes
1	Neuroactive ligand-receptor interaction20	11.3	LEPR, CGA, AVPR1B, FSHB, FSHR, F2R
2	CREB Pathway36	10.7	PIK3R1, BMP2, KDR, FGF4, FGFR4, IGF1
3	Glioma Invasiveness36	10.7	BMP2, FGF2, FGF4, F2R, GNRH1, GH1
4	14-3-3 Induced Intracellular Signaling36	10.6	PIK3R1, BMP2, FGF2, FGF4, FGFR4, IGF1
5	eNOS Signaling36	10.5	PIK3R1, BMP2, FGF4, FGFR4, GNRH1, CAV1
6	Breast Cancer Regulation by Stathmin136	10.1	PIK3R1, BMP2, FGF2, FGF4, FGFR4, GH2
7	Development Role of Activin A in cell differentiation and proliferation10	10.1	MYC, PBX1, CGA, FSHB, FSHR, CDKN1A
8	Development_Role of Activin A in cell differentiation and proliferation41	10.1	MYC, PBX1, CGA, FSHB, FSHR, CDKN1A
9	Development_Ligand-independent activation of ESR1 and ESR241	10.0	PIK3CA, PIK3R1, NCOA2, IRS1, CCND1, IGF1
10	Telomerase Components in Cell Signaling36	9.5	RB1, MYC, BMP2, KDR, FGF2, FGF4
11	Activation of PKC through GPCR36	9.5	PIK3R1, BMP2, KDR, FGF2, FGF4, FGFR4
12	DHA Signaling36	9.4	PIK3R1, BMP2, KDR, FGF2, FGF4, FGFR4
13	ERK Signaling36	9.4	PIK3R1, MYC, BMP2, FGF4, FGFR4, IL6
14	Development Ligand-independent activation of ESR1 and ESR210	9.4	PIK3CA, PIK3R1, NCOA2, IRS1, CCND1, GNAS
15	GPCR Pathway36	9.4	PIK3R1, BMP2, KDR, FOS, FGF2, FGF4
16	Akt Signaling36	9.3	PIK3R1, BMP2, LIF, IRS1, FGF4, FGFR4
17	JNK Pathway36	9.3	PIK3R1, BMP2, KDR, IRS1, FGF2, FGF4
18	PTEN Pathway36	9.3	PIK3R1, BMP2, KDR, FGF2, FGF4, FGFR4
19	Nuclear Receptor Activation by Vitamin-A36	9.3	BMP2, KDR, FGF2, FGF4, FGFR4, IL6
20	Rac1 Pathway36	9.2	PIK3R1, KDR, FGF2, FGF4, FGFR4, IL6
21	ERK5 Signaling36	9.2	MYC, BMP2, KDR, FOS, FGF4, FGFR4
22	IP3 Pathway36	9.1	PIK3R1, BMP2, KDR, FGF2, FGF4, FGFR4
23	mTOR Pathway36	9.1	PIK3R1, BMP2, IRS1, INS, FGF2, FGF4
24	Glioblastoma Multiforme36	9.1	PIK3R1, RB1, CDKN1A, CDKN1B, MGMT, APC
25	Renin-Angiotensin Pathway36	9.0	PIK3R1, BMP2, KDR, JAK2, FOS, FGF2
26	PPAR Pathway36	9.0	PIK3R1, BMP2, FGF2, FGF4, IL6, IGF1
27	TGF-Beta Pathway36	8.9	PIK3R1, BMP2, KDR, FOS, FGF2, FGF4
28	ILK Signaling36	8.9	PIK3R1, BMP2, KDR, FOS, IRS1, FGF2
29	Antioxidant Action of Vitamin-C36	8.8	BMP2, LIF, KDR, JAK2, FOS, FGF2
30	NF-KappaB (p50-p65) Pathway36	8.8	PIK3R1, BMP2, KDR, FGF2, FGF4, FGFR4
31	eIF2 Pathway36	8.8	PIK3R1, INS, FGF2, FGF4, FGFR4, IL6
32	p53 Mediated Apoptosis36	8.7	PIK3R1, BMP2, KDR, FGF2, FGF4, FGFR4
33	NF-KappaB Family Pathway36	8.7	PIK3R1, BMP2, KDR, FGF2, FGF4, FGFR4
34	Estrogen Pathway36	8.7	PIK3R1, NCOA2, NCOR2, BMP2, KDR, FOS
35	Cell cycle20	8.7	PCNA, RB1, MYC, CDKN1A, CDKN1B, CDKN2A
36	JAK-STAT Pathway36	8.7	PIK3R1, MYC, BMP2, KDR, JAK2, FOS
37	p38 Signaling36	8.6	BMP2, LIF, KDR, CDC25C, FGF2, FGF4
38	Mitochondrial Apoptosis36	8.6	PIK3R1, BMP2, KDR, CDKN2A, FGF2, FGF4
39	Tec Kinases Signaling36	8.6	PIK3R1, BMP2, JAK2, FOS, FGF2, FGF4
40	Apoptotic Pathways in Synovial Fibroblasts36	8.5	PIK3R1, BMP2, KDR, FGF2, FGF4, FGFR4
41	p70S6K Signaling36	8.3	PIK3R1, BMP2, KDR, JAK2, IRS1, INS
42	Cellular Apoptosis Pathway36	8.1	PIK3R1, BMP2, KDR, CDKN2A, FGF2, FGF4
43	Glioma20	8.1	PIK3CA, PIK3R1, RB1, CDKN1A, CDKN2A, CCND1
44	MAPK Signaling36	7.8	PIK3R1, MYC, BMP2, KDR, FOS, FGF2
45	Bladder cancer20	7.4	RB1, VEGFA, MYC, CDKN1A, CDKN2A, MMP2
46	Prostate cancer20	7.3	PIK3CA, PIK3R1, RB1, CDKN1A, CDKN1B, INS
47	Pancreatic Adenocarcinoma36	7.1	PIK3R1, RB1, BMP2, BIRC5, KDR, JAK2
48	Molecular Mechanisms of Cancer36	6.8	PIK3R1, RB1, MYC, BMP2, LIF, KDR
49	Pathways in cancer20	6.7	PIK3CA, PIK3R1, RET, RB1, VEGFA, MYC
50	Colorectal Cancer Metastasis36	6.3	PIK3R1, MYC, BIRC5, CDKN1A, MMP2, MMP9

Compounds related to pituitary tumor according to GeneDecks:

(show top 50)    (show all 449)

id	Compound	Score	Top Affiliating Genes
1	glucose32	11.0	PCSK2, PCSK1, FST, MKI67, MGMT, APC
2	levodopa32 9 9	13.0	CHGA, GH1, GHR, GHRH, TRH, DRD2
3	carbachol32 9 9	12.9	CGA, SST, CRH
4	clonidine32 9 9	12.8	CHGA, CGA, FGF2, IL1RAPL2, IGFBP3, IGF1
5	naloxone32 34 9 9	13.8	VIP, CGA, FOS, GNRH1, ESR1, GH1
6	triiodothyronine32	10.7	NCOA2, NCOR2, PCSK2, LEPR, CGA, IGFBP3
7	catecholamine32	10.7	RET, SCG5, CHGB, CHGA, IL1RAPL2, ENO2
8	dbc-amp32	10.4	NCAM1, VIP, LIF, CGA, CDKN1B, FOS
9	dihydrotestosterone32 9 18 9	13.4	NCOA2, VIP, BMP2, CGA, FST, FGF2
10	leuprolide acetate32	10.4	CGA, FSHB, IGF1, GNRH1, GNRHR, ESR1
11	raloxifene32 9 9	12.3	BMP2, CDKN1B, IGFBP3, IGF1, GNRH1, GNRHR
12	androstenedione32 18	11.3	PBX1, LEPR, CGA, FSHR, FST, INS
13	atropine32 9 9	12.2	PCNA, VIP, CALCA, GH1, GHRH, GHRL
14	acth32	10.2	PCSK2, PCSK1, VIP, LNPEP, PBX1, SCG5
15	calcium32 9 18 9	13.0	CNTN2, SFRP4, PCSK2, PCSK1, RB1, VIP
16	pge232	10.0	VIP, LNPEP, BMP2, LIF, CGA, FSHR
17	gnrh32	10.0	NCAM1, PCSK1, PBX1, LEPR, CGB7, FSHB
18	atp32	9.6	PIK3CA, RFC2, NCAM1, RET, RB1, LIF
19	calcitriol32 42 9 18 9	13.5	NCOA2, SFRP4, RB1, MYC, BMP2, LIF
20	epinephrine32 9 18 9	12.4	VIP, CHGA, CGA, JAK2, MMP2, MMP9
21	estradiol32 9 18 9	12.4	NCOA2, NCOR2, PCNA, RB1, LIF, BIRC5
22	progestin32	9.4	PIK3R1, VEGFA, LIF, KDR, CGA, CCND1
23	leucine32	9.4	PIK3CA, PIK3R1, RET, CNTN2, RB1, LNPEP
24	okadaic acid32 42	10.2	PIK3CA, PIK3R1, RB1, MYC, CDC25C, FOS
25	prostaglandin32	9.1	VIP, LIF, CGA, FST, MMP9, IL1RAPL2
26	fatty acid32	8.7	LGALS3, LEPR, CDKN1B, CDKN2A, MKI67, IRS1
27	aspartate32	8.5	PIK3R1, RET, PCNA, VIP, CGA, AURKA
28	matrigel32	8.5	PIK3CA, PIK3R1, NCAM1, RB1, VEGFA, BMP2
29	phosphotyrosine32	8.4	PIK3CA, PIK3R1, RET, KDR, SCG5, JAK2
30	trastuzumab32 34 9 9	11.3	PIK3CA, PIK3R1, BIRC5, KDR, CDKN1B, CCND1
31	hydrocortisone32 9 9	10.3	LIF, PBX1, KDR, MMP2, INS, FGF2
32	cholesterol32 9 18 9	11.1	PIK3CA, PIK3R1, NCOA2, RB1, BMP2, LIF
33	glycogen32 18	9.0	PIK3CA, PIK3R1, LNPEP, MYC, LIF, LGALS3
34	cysteine32	8.0	CNTN2, PCNA, LIF, PARP1, KDR, SCG5
35	15-deoxy-delta-12,14-prostaglandin j232	7.8	VEGFA, MYC, BIRC5, JAK2, CDKN1A, FOS
36	imatinib32 34 9 9	10.6	PIK3CA, PIK3R1, RET, VIP, VEGFA, MYC
37	5-aza-2deoxycytidine32	7.5	PCNA, MYC, FST, JAK2, CDKN1A, CDKN2A
38	ciglitazone32	7.5	PARP1, CDKN1A, CDKN1B, MMP2, MMP9, IL6
39	tgf beta132	7.1	BMP2, LIF, KDR, FST, CDKN1A, CDKN1B
40	rosiglitazone32 9 18 9	10.1	PIK3CA, JAK2, CDKN1A, MMP2, MMP9, IRS1
41	gemcitabine32 34 9 9	10.0	PCNA, VEGFA, MYC, BIRC5, PARP1, KDR
42	testosterone32 9 18 9	9.7	PIK3CA, PIK3R1, NCAM1, NCOA2, NCOR2, RET
43	arsenite32 18	7.7	PIK3CA, PIK3R1, CNTN2, PCNA, VEGFA, MYC
44	alanine32	6.5	NCAM1, RET, CNTN2, PCNA, VIP, LNPEP
45	thymidine32 18	7.5	PIK3CA, PIK3R1, CNTN2, PCNA, RB1, VIP
46	paraffin32	6.2	NCAM1, RET, PCNA, RB1, VEGFA, MYC
47	tamoxifen32 34 9 9	8.9	PIK3CA, NCOA2, NCOR2, PCNA, VEGFA, MYC
48	curcumin32	5.4	VEGFA, MYC, BIRC5, PARP1, JAK2, CDKN1A
49	pd 98,05932	5.0	PIK3CA, PIK3R1, RET, RB1, MYC, BMP2
50	nitric oxide32 9 18 9	INF	NCAM1, RB1, BMP2, LIF, BIRC5, KDR

Cellular components related to pituitary tumor according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	neuronal cell body	GO:043025	10.5	ADCY10, NCOA2, CNTN2, PCSK1, APC, CALCA
2	cell surface	GO:009986	9.9	TRHR, NGFR, ACVR2A, TNF, ACVR1B, ACVRL1
3	integral to plasma membrane	GO:005887	9.8	SSTR1, DRD2, TNF, TRHR, GHR, CAV1
4	secretory granule	GO:030141	9.7	TF, POMC, GAL, THBS1, LTF, PCSK2
5	protein complex	GO:043234	9.0	CXADR, PRKCA, TP53, PRKAR1A, SYP, PTGS2
6	plasma membrane	GO:005886	9.0	GPRC6A, F2R, GNAS, GNRHR, CASR, CAV1
7	extracellular region	GO:005576	8.1	GDNF, GAL, POMC, CRH, NRP1, SST
8	cytosol	GO:005829	7.5	GSTT1, MEN1, GSTM1, IRS1, CDC25C, CDKN2A
9	nucleoplasm	GO:005654	7.3	EP300, E2F1, HDAC2, NEUROD1, PGR, POU2F1
10	extracellular space	GO:005615	7.1	PCSK2, GNRH1, EGF, CALCA, GH1, GHR
11	cytoplasm	GO:005737	6.9	SFRP4, FGFR4, MEN1, APC, ENO1, IKZF1
12	nucleus	GO:005634	5.1	FGF2, EP300, E2F1, HDAC2, NCOA2, IRS1

Biological processes related to pituitary tumor according to GeneDecks:

(show top 50)    (show all 87)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of multicellular organism growth	GO:040018	11.1	DRD2, GHSR, GHRL, GHRHR, GHRH, GHR
2	female pregnancy	GO:007565	11.1	LNPEP, CRH, CRHR1, STAT5B, ADCYAP1, PRL
3	somatostatin signaling pathway	GO:038170	11.1	SSTR3, SSTR1, SSTR4, SSTR5, SSTR2
4	peptide hormone processing	GO:016486	10.9	POMC, SCG5, CGA, FSHB, TSHB, PCSK1
5	growth hormone secretion	GO:030252	10.9	GHRHR, GHRH, GAL, GHRL, GHSR
6	positive regulation of insulin-like growth factor receptor signaling pathway	GO:043568	10.9	IGFBP3, IGF1, GH1, GHRHR, GHSR, GHRH
7	JAK-STAT cascade involved in growth hormone signaling pathway	GO:060397	10.7	STAT5B, JAK2, IRS1, GH2, GHR, PRL
8	negative regulation of sequence-specific DNA binding transcription factor activity	GO:043433	10.7	PBX1, RB1, SFRP4, MEN1, ID3, ESR1
9	hormone-mediated signaling pathway	GO:009755	10.7	GHR, THRA, TRH, GHSR, GHRL, JAK2
10	fibroblast growth factor receptor signaling pathway	GO:008543	10.7	CREB1, PDPK1, PRKCD, PRKAR1A, PRKCA, PRKACA
11	response to estrogen stimulus	GO:043627	10.6	ESR1, PPARG, GHRL, GHRHR, CAV1, CCND1
12	cellular response to insulin stimulus	GO:032869	10.4	IRS1, CCND2, GHR, PARP1, GHRHR, GHSR
13	lactation	GO:007595	10.3	CAV1, GHRHR, CREB1, NME1, PRL, STAT5B
14	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.2	DRD2, PRKCA, TNF, BMP2, F2R, FGFR4
15	nerve growth factor receptor signaling pathway	GO:048011	10.2	PIK3CA, IRS1, PRKCD, PRKACA, PRKCA, ADCYAP1
16	chromosome organization	GO:051276	10.2	APC, MYC, PTTG3P, PTTG1, PTTG2, TP53
17	G-protein coupled receptor signaling pathway	GO:007186	10.2	JAK2, CASR, GHRL, TRHR, SST, SSTR4
18	positive regulation of osteoblast differentiation	GO:045669	10.1	FGF2, MEN1, SFRP2, IL6, ACVR2A, IL6R
19	phosphatidylinositol-mediated signaling	GO:048015	10.0	PDPK1, NGF, PTEN, IGF1, PIK3CA, PIK3R1
20	cell-cell signaling	GO:007267	10.0	ADCYAP1, PGR, POMC, TSHB, CRB1, NRP1
21	response to ethanol	GO:045471	10.0	GNRH1, TRH, PRKCA, CCND1, CCND2, MGMT
22	activation of phospholipase C activity	GO:007202	10.0	AVPR1B, PRKACA, PRKCD, PRKAR1A, EGFR, NGF
23	response to estradiol stimulus	GO:032355	9.9	AURKA, MMP9, ENO2, CCND2, ESR1, GH1
24	G1 phase of mitotic cell cycle	GO:000080	9.9	RB1, E2F1, CDKN1A, CDKN1B, SKP2, CUL1
25	negative regulation of cell growth	GO:030308	9.8	HNF4A, PPARG, SFRP2, RB1, CDKN1B, CDKN1A
26	epidermal growth factor receptor signaling pathway	GO:007173	9.8	PRKCA, PIK3CA, PIK3R1, CDKN1B, PTEN, CREB1
27	signal transduction	GO:007165	9.7	IRS1, GDNF, PRKACA, EPS8, CRH, WIF1
28	regulation of insulin secretion	GO:050796	9.7	PRKAR1A, PCSK1, INS, GNAS, HNF4A, TNF
29	transcription initiation from RNA polymerase II promoter	GO:006367	9.7	NCOR2, HNF4A, TCF4, PGR, RUNX2, THRB
30	cell cycle arrest	GO:007050	9.4	TCF7L2, CUL1, TP53, APC, MEN1, CDKN1B
31	transforming growth factor beta receptor signaling pathway	GO:007179	9.4	ACVRL1, MYC, PARP1, FSHB, FOS, MEN1
32	blood coagulation	GO:007596	9.4	PDPK1, EGF, THBS1, TF, PRKAR1A, PRKCD
33	response to glucocorticoid stimulus	GO:051384	9.2	CAV1, GHR, GHRHR, TNF, PTGS2, NGF
34	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	9.1	EP300, ESR1, ESR2, JAK2, PPARG, NGF
35	negative regulation of transcription from RNA polymerase II promoter	GO:000122	9.0	FST, MEN1, ENO1, PARP1, BMP2, MYC
36	negative regulation of transcription, DNA-dependent	GO:045892	8.9	SFRP2, PPARG, NR1H2, E2F1, HDAC2, POU2F1
37	positive regulation of apoptotic process	GO:043065	8.8	TP53, TNF, PTGS2, CTNNB1, AGTR2, NEUROD1
38	positive regulation of cell migration	GO:030335	8.8	THBS1, F2R, APC, INS, JAK2, VEGFA
39	positive regulation of MAPK cascade	GO:043410	8.7	LIF, KDR, INS, IL6, IL6R, F2R
40	endocrine pancreas development	GO:031018	8.6	IL6, INSM1, IAPP, INS, NEUROD1, HNF4A
41	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	8.6	TP53, NRP1, GHR, GH1, IGF1, IL6R
42	positive regulation of nitric oxide biosynthetic process	GO:045429	8.5	AGTR2, INS, ESR1, JAK2, EGFR, PTGS2
43	negative regulation of cell proliferation	GO:008285	8.1	SSTR3, MEN1, FGF2, CDKN2A, CDKN1B, CDKN1A
44	positive regulation of cell proliferation	GO:008284	7.6	EPCAM, HDAC2, TGFBR2, EGFR, EGF, PTEN
45	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.6	NCOA2, TNF, DRD2, TBX19, CTNNB1, PPARG
46	positive regulation of transcription, DNA-dependent	GO:045893	7.6	E2F1, EGF, ACVRL1, AGTR2, TFAP2A, TCF4
47	negative regulation of apoptotic process	GO:043066	6.9	INS, HDAC2, CDKN1B, FGF4, IL6, APC
48	response to glucose stimulus	GO:009749	INF	, PCSK1, TRH, NNAT, HNF4A, TCF7L2
49	response to hypoxia	GO:001666	INF	MMP9, BMP2, VEGFA, STAT5B, , EP300
50	response to drug	GO:042493	INF	CREB1, NGF, THBS1, TGFA, TGFBR2, NME1

Molecular functions related to pituitary tumor according to GeneDecks:

(show all 20)

id	Name	GO ID	Score	Top Affiliating Genes
1	somatostatin receptor activity	GO:004994	11.0	SSTR5, SSTR4, SSTR3, SSTR2, SSTR1
2	neuropeptide hormone activity	GO:005184	10.9	VIP, ADCYAP1, CORT, GAL, CRH, TRH
3	transmembrane receptor protein serine/threonine kinase activity	GO:004675	10.6	TGFBR2, ACVRL1, ACVR1B, ACVR2A
4	growth factor binding	GO:019838	10.6	GHR, GHRHR, KDR, ACVR2A, ACVR1B, NRP1
5	receptor signaling protein serine/threonine kinase activity	GO:004702	10.4	ACVR1B, ACVR2A, TGFBR2, ACVRL1
6	hormone activity	GO:005179	10.4	POMC, PRL, TSHB, CHGB, VIP, CGA
7	RNA polymerase II activating transcription factor binding	GO:001102	10.4	RB1, POU1F1, EP300, NEUROD1, CREB1
8	steroid hormone receptor activity	GO:003707	10.2	NR1H2, ESR1, ESR2, PPARG, NR5A1, THRB
9	receptor binding	GO:005102	10.2	LIF, CRH, HNF4A, CAV1, CALCA, F2R
10	fibronectin binding	GO:001968	9.9	THBS1, IGFBP3, MMP9, VEGFA, SFRP2
11	growth factor activity	GO:008083	9.7	NUDT6, LIF, FGF2, OGN, TGFA, NGF
12	sequence-specific DNA binding	GO:043565	9.6	HNF4A, TCF7L2, SNAI1, POU2F1, POU1F1, NEUROD1
13	double-stranded DNA binding	GO:003690	9.4	STAT5B, NEUROD1, EGFR, NR5A1, CTNNB1, MEN1
14	protein kinase binding	GO:019901	9.3	TP53, PTEN, PDPK1, ACVRL1, TCF7L2, AURKA
15	chromatin binding	GO:003682	9.1	PPARG, CTNNB1, TP53, PROP1, NCOA2, TFAP2A
16	transcription regulatory region DNA binding	GO:044212	8.8	TFAP2A, MEN1, FOS, TCF7L2, TNF, CTNNB1
17	transcription factor binding	GO:008134	8.8	AIP, EP300, E2F1, HDAC2, NEUROD1, RUNX1
18	sequence-specific DNA binding transcription factor activity	GO:003700	8.2	FOS, CREB1, THRA, THRB, TCF4, TCF7L2
19	enzyme binding	GO:019899	8.1	TP53, ESR2, CAV1, CCND1, IL6R, BIRC5
20	protein binding	GO:005515	2.8	HPSE, MKI67, FOS, MMP9, MMP2, CDC25C