MCID: PTT037
MIFTS: 43

Pituitary Tumors malady

Cancer diseases category

Summaries for Pituitary Tumors

About this section
Sources:
33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 Your pituitary gland is a pea-sized gland at the base of your brain. the pituitary is the "master control gland" - it makes hormones that affect growth and the functions of other glands in the body. pituitary tumors are common, but often they don't cause health problems. most people with pituitary tumors never even know they have them. the most common type of pituitary tumor produces hormones and disrupts the balance of hormones in your body. this can cause endocrine diseases such as cushing's syndrome and hyperthyroidism. symptoms of pituitary tumors include headaches vision problems nausea and vomiting problems caused by the production of too many hormones pituitary tumors are usually curable. treatment is often surgery to remove the tumor. other options include medicines, radiation therapy, and chemotherapy.

MalaCards: Pituitary Tumors, also known as pituitary neoplasms, is related to acromegaly and pituitary adenoma. An important gene associated with Pituitary Tumors is PTTG1IP (pituitary tumor-transforming 1 interacting protein), and among its related pathways are Signaling by GPCR and Class A/1 (Rhodopsin-like receptors). The drugs octreotide and octreotide acetate and the compounds acth and octreotide have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and hypothalamus, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

NINDS:43 The pituitary is a small, bean-sized gland that is below the hypothalamus, a structure at the base of the brain, by a thread-like stalk that contains both blood vessels and nerves.

Wikipedia:63 Pituitary adenomas are noncancerous tumors that occur in the pituitary gland. Pituitary adenomas are... more...

Aliases & Classifications for Pituitary Tumors

About this section
Sources:
43NINDS, 44Novoseek, 33MedlinePlus, 60UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

pituitary tumors 43 44 33
pituitary neoplasms 60


Related Diseases for Pituitary Tumors

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pituitary Tumors via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 159)
idRelated DiseaseScoreTop Affiliating Genes
1acromegaly30.8SST, PRL, GH1
2pituitary adenoma30.8GNAS, APC, POMC, TRH, AIP, SST
3adenoma30.8POMC, CNC, PTTG1, TSHB, TRH, AIP
4thyroiditis30.8POMC, TRH
5pituitary cancer30.7PRL, POMC
6prolactinoma30.6SST, AIP, TRH, POMC, PTTG1, SSTR1
7pituitary apoplexy30.5POMC, TRH, PRL
8thyroid cancer30.4PTTG1, TRH, APC, GNAS
9hyperthyroidism30.2GNAS, GH1, PRL, SST, TRH, TSHB
10meningioma30.2SST, SSTR5
11hyperprolactinemia30.1GNAS, GH1, PRL, SST, TRH, POMC
12hypothyroidism30.1GNAS, GH1, PRL, TRH, POMC, TSHB
13prostate cancer30.1GNAS, APC, SSTR5, SSTR1, PTTG1
14craniopharyngioma30.1GH1, PRL, TRH, POMC
15panhypopituitarism30.1GH1, PRL, POMC, TSHB
16acth-secreting pituitary adenoma30.1GH1, PRL, POMC
17pancreatitis30.0SST
18empty sella syndrome30.0GH1, PRL
19diabetes insipidus30.0POMC, TRH, PRL
20pancreatic cancer30.0ACVR1B, SST, SSTR1, SSTR5
21exophthalmos30.0TRH
22gigantism29.8GNAS, GH1, PRL, SST, AIP
23mccune albright syndrome29.8GNAS, APC, GH1, PRL
24hypoglycemia29.8GH1, PRL, SST, TRH, POMC
25thyroid medullary carcinoma29.8SSTR5, SSTR1, SST, POMC
26carney complex29.8GNAS, AIP, POMC
27hypogonadism29.8POMC, TRH, PRL, GH1
28goiter29.8TSHB, TRH, GNAS
29nelson syndrome29.8POMC, SST, PRL
30amenorrhea29.8POMC, TRH, PRL
31leydig cell tumor29.8GNAS, POMC
32colorectal cancer29.8PTTG1, APC
33pituitary gland disease29.8GH1, PRL
34infertility29.8PRL
35lung cancer29.8SST, POMC
36prolactin producing pituitary tumor10.5
37growth hormone secreting pituitary adenoma10.3
38tsh producing pituitary tumor10.3
39retinoblastoma10.3
40esophagitis10.2
41squamous cell carcinoma10.2
42retinitis10.1
43pituitary hypoplasia10.0
44scotoma10.0
45astrocytoma10.0
46functioning pituitary adenoma10.0
47hepatocellular carcinoma10.0
48hormone producing pituitary cancer10.0
49multiple myeloma10.0
50myeloma10.0

Graphical network of the top 20 diseases related to Pituitary Tumors:



Diseases related to pituitary tumors

Clinical Features for Pituitary Tumors

About this section

Drugs & Therapeutics for Pituitary Tumors

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pituitary Tumors

Drug clinical trials:

Search ClinicalTrials for Pituitary Tumors

Search NIH Clinical Center for Pituitary Tumors

Search CenterWatch for Pituitary Tumors

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Pituitary Tumors

About this section

Anatomical Context for Pituitary Tumors

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Pituitary Tumors:

32
Pituitary, Brain, Hypothalamus

Animal Models for Pituitary Tumors or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Pituitary Tumors:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.2GNAS, APC, GH1, PRL, SSTR5, SSTR1
2MP:000537911.2PTTG1, GNAS, APC, GH1, PRL, SSTR5
3MP:000363111.1PRL, GH1, APC, GNAS, SSTR1, SST
4MP:000537811.1SSTR5, GH1, APC, GNAS, SST, AIP
5MP:000301210.8PTTG1, ACVR1B, POMC, SST, APC, GNAS
6MP:000537010.7GNAS, APC, GH1, PRL, AIP, POMC
7MP:000537510.5GNAS, APC, GH1, POMC, PTTG1

Publications for Pituitary Tumors

About this section

Genetic Variations for Pituitary Tumors

About this section

Expression for genes affiliated with Pituitary Tumors

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pituitary Tumors

Search GEO for disease gene expression data for Pituitary Tumors.

Pathways for genes affiliated with Pituitary Tumors

About this section
Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database
See all sources

Pathways related to Pituitary Tumors according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.1APC, GH1, PRL, SSTR5, SSTR1, SST
2
Hide members
11.0TSHB, GNAS, GH1, PRL, SSTR5, SSTR1

Compounds for genes affiliated with Pituitary Tumors

About this section
Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
See all sources

Compounds related to Pituitary Tumors according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1acth4411.5TSHB, PRL, GH1, APC, GNAS, SST
2octreotide44 59 28 1114.4GH1, GNAS, SSTR5, SSTR1, SST, TRH
3ribonucleic acid4411.4POMC, PTTG1, SSTR1, SSTR5, GH1, GNAS
4norepinephrine44 11 2413.3POMC, TRH, GH1, SST, APC, GNAS
5dopamine44 28 11 2414.3GNAS, PTTG1, TRH, APC, SSTR5, SSTR1
6adenylate4411.3SST, TRH, GH1, APC, POMC, GNAS
7thyroxine44 2412.3SST, TSHB, GH1, PRL, POMC, TRH
8gnrh4411.2GNAS, GH1, PRL, SST, TRH, POMC
9lanreotide44 2812.2PRL, SSTR5, SSTR1, GH1, SST
10naloxone44 49 28 1114.2SST, PRL, TRH, GH1, POMC
11clonidine44 28 1113.2GH1, POMC, TRH, SST, PRL
12triiodothyronine4411.2GH1, TRH, POMC, TSHB, PRL
13thymidine44 2412.2TSHB, PTTG1, GNAS, GH1, TRH, SSTR5
14hydrocortisone44 2 59 1114.2POMC, TRH, SST, PRL, GH1
15ghrp4411.2GH1, PRL, TRH, SST
16bromocriptine28 44 1113.1POMC, TRH, SST, PRL
17hexarelin44 2812.1PRL, POMC, GH1, SST
18pyridostigmine44 1112.1GH1, SST, PRL, TRH
19progesterone44 59 28 11 2415.1GH1, POMC, TRH, PRL, APC, GNAS
20epinephrine44 11 2413.1SST, APC, POMC, PRL, GH1
21quinagolide4411.1SST, PRL, GH1
22pasireotide44 1112.1SSTR5, SSTR1, SST
23(1r,1s,3r/1r,1r,3s)-l-054,2645911.1SSTR1, SST, SSTR5
24levodopa44 1112.0TRH, PRL, GH1, SST
25cyclosomatostatin5911.0SSTR5, SST, SSTR1
26cyn 1548065911.0SSTR5, SST, SSTR1
27somatostatin59 2412.0SSTR5, SSTR1, SST
28111in-pentetreotide4411.0SST, SSTR1, SSTR5
295-hydroxytryptophan4411.0PRL, GH1, SST
30glucose4411.0POMC, TRH, APC
31sulpiride44 28 1113.0TRH, PRL, GH1
32domperidone44 28 1113.0SST, PRL, TRH
33testosterone44 59 11 2414.0PRL, POMC, APC, GH1, TRH, SST
34fenfluramine28 44 1113.0POMC, TRH, PRL
35metoclopramide44 1112.0PRL, TRH, GH1
36naltrexone44 49 28 1114.0GH1, POMC, PRL
37cabergoline28 44 1113.0SST, GH1, PRL
38estrogen4410.9TSHB, PTTG1, TRH
39l-817,8182810.9SSTR1, SSTR5
40pphp4410.9APC, GNAS
41apomorphine44 28 1112.9TRH, PRL, GH1
42somatuline4410.8SST, GH1
43bim 230502810.8SSTR1, SSTR5
44des-aa5-[d-trp8]srif2810.7SSTR5, SSTR1
45som-2302810.7SSTR5, SSTR1
46pitressin4410.7POMC, SST
47isoproterenol44 1111.6SST, GNAS, APC, GH1
48srif-282810.6SSTR5, SSTR1
49forskolin44 49 1112.5POMC
50pertussis4410.4SST, APC, GH1

GO Terms for genes affiliated with Pituitary Tumors

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Pituitary Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.9GH1, PRL, SST, TRH, POMC, TSHB
2secretory granuleGO:03014110.4POMC, TRH, PRL

Biological processes related to Pituitary Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromosome organizationGO:05127610.8PTTG2, PTTG1, PTTG3P, APC
2cell-cell signalingGO:00726710.8SSTR1, SST, TRH, POMC, TSHB
3peptide hormone processingGO:01648610.6TSHB, POMC
4response to nutrientGO:00758410.6SST, SSTR1, PRL
5positive regulation of JAK-STAT cascadeGO:04642710.3PRL, GH1

Molecular functions related to Pituitary Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.8TSHB, POMC, SST, PRL, GH1
2SH3 domain bindingGO:01712410.6PTTG2, PTTG1, PTTG3P
3prolactin receptor bindingGO:00514810.5GH1, PRL
4somatostatin receptor activityGO:00499410.3SSTR1, SSTR5

Products for genes affiliated with Pituitary Tumors

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pituitary Tumors

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet