MCID: PTT037
MIFTS: 53

Pituitary Tumors malady

Cancer category

Summaries for Pituitary Tumors

Sources:
34MedlinePlus, 44NINDS, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Your pituitary gland is a pea-sized gland at the base of your brain. the pituitary is the "master control gland" - it makes hormones that affect growth and the functions of other glands in the body. pituitary tumors are common, but often they don't cause health problems. most people with pituitary tumors never even know they have them. the most common type of pituitary tumor produces hormones and disrupts the balance of hormones in your body. this can cause endocrine diseases such as cushing's syndrome and hyperthyroidism. symptoms of pituitary tumors include headaches vision problems nausea and vomiting problems caused by the production of too many hormones pituitary tumors are usually curable. treatment is often surgery to remove the tumor. other options include medicines, radiation therapy, and chemotherapy.

MalaCards: Pituitary Tumors, also known as pituitary neoplasms, is related to acromegaly and adenoma. An important gene associated with Pituitary Tumors is PTTG1IP (pituitary tumor-transforming 1 interacting protein), and among its related pathways are Signaling by GPCR and Class A/1 (Rhodopsin-like receptors). The drugs octreotide and octreotide acetate and the compounds acth and octreotide have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and lung, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

NINDS:44 The pituitary is a small, bean-sized gland that is below the hypothalamus, a structure at the base of the brain, by a thread-like stalk that contains both blood vessels and nerves.

Wikipedia:64 Pituitary adenomas are noncancerous tumors that occur in the pituitary gland. Pituitary adenomas are... more...

Aliases & Classifications for Pituitary Tumors

Sources:
44NINDS, 45Novoseek, 34MedlinePlus, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

pituitary tumors 44 45 34
pituitary neoplasms 61


Related Diseases for Pituitary Tumors

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pituitary Tumors via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 145)
idRelated DiseaseScoreTop Affiliating Genes
1acromegaly30.9GNAS, APC, GH1, PRL, SSTR5, SSTR1
2adenoma30.8POMC, CNC, PTTG1, TSHB, TRH, AIP
3prolactinoma30.6SST, AIP, TRH, POMC, PTTG1, SSTR1
4multiple endocrine neoplasia30.5CNC, GNAS
5pituitary apoplexy30.5POMC, TRH, PRL
6thyroid cancer30.4PTTG1, TRH, APC, GNAS
7gigantism30.2GNAS, GH1, PRL, SST, AIP
8hyperprolactinemia30.1GNAS, GH1, PRL, SST, TRH, POMC
9panhypopituitarism30.1GH1, PRL, POMC, TSHB
10acth-secreting pituitary adenoma30.1GH1, PRL, POMC
11empty sella syndrome30.1GH1, PRL
12diabetes insipidus30.1POMC, TRH, PRL
13exophthalmos30.1TRH
14mccune albright syndrome29.9GNAS, APC, GH1, PRL
15hypoglycemia29.9GH1, PRL, SST, TRH, POMC
16thyroid medullary carcinoma29.9SSTR5, SSTR1, SST, POMC
17carney complex29.9GNAS, AIP, POMC
18nelson syndrome29.9POMC, SST, PRL
19growth hormone deficiency29.9GH1, PRL, POMC
20amenorrhea29.9POMC, TRH, PRL
21insulin resistance29.9SST, GH1, GNAS
22colorectal cancer29.9PTTG1, APC
23infertility29.9PRL
24somatostatin analog10.5
25prolactin producing pituitary tumor10.5
26pituitary tumor, invasive10.4
27growth hormone secreting pituitary adenoma10.3
28squamous cell carcinoma10.3
29tsh producing pituitary tumor10.2
30headache10.2
31esophageal squamous cell carcinoma10.2
32n syndrome10.2
33pituitary hypoplasia10.1
34scotoma10.1
35astrocytoma10.1
36lymphocytic hypophysitis10.1
37familial isolated pituitary adenoma10.1
38adenohypophysitis10.1
39pituitary adenoma10.0GNAS, APC, POMC, TRH, AIP, SST
40adrenal gland hyperfunction10.0POMC, TRH, SST, PRL, GH1, CNC
41hypothyroidism10.0GNAS, GH1, PRL, TRH, POMC, TSHB
42hyperthyroidism10.0GNAS, GH1, PRL, SST, TRH, TSHB
43carcinoid syndrome10.0GNAS, GH1, SSTR5, SSTR1, SST, POMC
44precocious puberty10.0GNAS, APC, GH1, PRL, POMC
45gastrinoma10.0APC, GH1, SSTR5, SSTR1, SST
46hypopituitarism10.0GH1, PRL, SST, TRH, POMC
47pheochromocytoma10.0GNAS, SSTR5, SSTR1, SST, POMC
48prostate cancer10.0GNAS, APC, SSTR5, SSTR1, PTTG1
49thyrotropin deficiency, isolated10.0GH1, PRL, POMC, TSHB
50craniopharyngioma10.0GH1, PRL, TRH, POMC

Graphical network of the top 20 diseases related to Pituitary Tumors:



Diseases related to pituitary tumors

Clinical Features for Pituitary Tumors

Drugs & Therapeutics for Pituitary Tumors

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pituitary Tumors

Drug clinical trials:

Search ClinicalTrials for Pituitary Tumors

Search NIH Clinical Center for Pituitary Tumors

Search CenterWatch for Pituitary Tumors

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Pituitary Tumors

Anatomical Context for Pituitary Tumors

Sources:
33MalaCards
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MalaCards organs/tissues related to Pituitary Tumors:

33
Skin, Brain, Lung, Cortex, Small intestine, Pancreas, Thyroid, Adrenal gland, Breast, Prostate, Testis, T cells, Endothelial, Hypothalamus, Pancreatic islet, Adrenal cortex, Pituitary, Testis germ, Testis leydig

Animal Models for Pituitary Tumors or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Pituitary Tumors

Sources:
51PubMed
See all sources

Articles related to Pituitary Tumors:

(show top 50)    (show all 559)
idTitleAuthorsYear
1
Functional Pituitary Tumors Masquerading as Primary Glaucoma and Effect of Hypophysectomy on Intraocular Tension. (23970340)
2013
2
GFAP-Cre-mediated transgenic activation of Bmi1 results in pituitary tumors. (22574128)
2012
3
Management of large aggressive nonfunctional pituitary tumors: experimental medical options when surgery and radiation fail. (23040745)
2012
4
Pituitary tumors: advances in neuroimaging. (19955765)
2010
5
PRKAR1A and the evolution of pituitary tumors. (20451576)
2010
6
E2F1 induces pituitary tumor transforming gene (PTTG1) expression in human pituitary tumors. (19837943)
2009
7
Pituitary tumors in childhood: update of diagnosis, treatment and molecular genetics. (18416659)
2008
8
Nonfunctioning pituitary tumors and pituitary incidentalomas. (18226735)
2008
9
Survivin products in pituitary tumors. (19112393)
2008
10
The 2004 World Health Organization classification of pituitary tumors: what is new? (16328527)
2006
11
Incidence of pituitary tumors in the human population of Croatia. (16617591)
2006
12
Classification and pathology of pituitary tumors. (16311407)
2005
13
Genetics and proteomics of pituitary tumors. (16311409)
2005
14
Pituitary adenoma: a DNA flow cytometric study of 192 clinicopathologically characterized tumors. (15803804)
2005
15
The evolution of Harvey Cushing's surgical approach to pituitary tumors from transsphenoidal to transfrontal. (16175871)
2005
16
Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors. (15644399)
2005
17
Treatment of pituitary tumors: surgery. (16311412)
2005
18
Clinical and endocrine aspects of pituitary tumors. (15494816)
2004
19
Quality of life in patients with pituitary tumors: a preliminary study. (12747133)
2003
20
New procedure to remove pituitary tumors produces similar clinical outcomes and satisfies patients more than standard approach. (12817577)
2003
21
Diagnosis and management of pituitary tumors: recent advances. (15024895)
2003
22
The expression of the F-box protein Skp2 is negatively associated with p27 expression in human pituitary tumors. (14558671)
2002
23
Reproductive disturbances, pituitary lactotrope adenomas, and mammary gland tumors in transgenic female mice producing high levels of human chorionic gonadotropin. (12239120)
2002
24
Determination of the proliferation and apoptotic index in adrenocorticotropin-secreting pituitary tumors : comparison between micro- and macroadenomas. (10623673)
2000
25
Conventional radiotherapy for pituitary tumors. (11082172)
2000
26
Expression of pituitary adenylate cyclase-activating polypeptide (PACAP) and the PACAP-selective receptor in cultured rat astrocytes, human brain tumors, and in response to acute intracranial injury. (10867818)
2000
27
Prevalence of pituitary tumors among diabetic cats with insulin resistance. (10844968)
2000
28
Clinical and biochemical characteristics of growth hormone-secreting pituitary tumors. (11215051)
2000
29
Analysis of cyclin D1 (CCND1) allelic imbalance and overexpression in sporadic human pituitary tumors. (10473097)
1999
30
Octreotide suppresses the incretin glucagon-like peptide (7-36) amide in patients with acromegaly or clinically nonfunctioning pituitary tumors and in healthy subjects. (10377503)
1999
31
Reverse transcription polymerase chain reaction analysis of pituitary hormone, Pit-1 and steroidogenic factor-1 messenger RNA expression in pituitary tumors. (11081157)
1999
32
Nerve growth factor in pituitary development and pituitary tumors. (9578983)
1998
33
Growth hormone secretagogue receptor expression in human pituitary tumors. (9851770)
1998
34
Dietary energy restriction abolishes development of prolactin-producing pituitary tumors in Fischer 344 rats treated with 17beta-estradiol. (9808162)
1998
35
Testing the hypothalamic-pituitary-adrenal axis in survivors of childhood brain and skull-based tumors. (9177419)
1997
36
A conformal technique for irradiation of pituitary tumors. (9136108)
1997
37
Diagnosis and management of nonfunctioning pituitary tumors. (8712806)
1996
38
Purine-binding factor (nm23) gene expression in pituitary tumors: marker of adenoma invasiveness. (7745027)
1995
39
Effect of cabergoline, a dopamine agonist, on estrogen-induced rat pituitary tumors: in vitro culture studies. (7670571)
1995
40
Anterior pituitary responsiveness in central Cushing disease and in Cushing syndrome caused by adrenal cortex tumors, as well as in simple obesity]. (7862432)
1995
41
A transforming growth factor-alpha pathway is expressed in GH4C1 rat pituitary tumors and appears necessary for tumor formation. (8013379)
1994
42
Gonadotropin-releasing hormone receptor mRNA expression by human pituitary tumors in vitro. (8200967)
1994
43
Galanin receptors from human pituitary tumors assayed with human galanin as ligand. (7694774)
1993
44
Advances in diagnostic techniques of pituitary tumors and prolactinomas. (1591282)
1992
45
Chronic somatostatin analog administration in patients with alpha-subunit-secreting pituitary tumors. (1358910)
1992
46
Structural differences between dopamine D2 receptors present in a rat pituitary adenoma and in transplantable rat pituitary tumors 7315a and MtTW15. (1968089)
1990
47
Free alpha subunit of the pituitary glycoprotein hormones. Measurement in serum and tissue of patients with pituitary tumors. (1699408)
1990
48
Pituitary-like proopiomelanocortin transcripts in human Leydig cell tumors. (2394836)
1990
49
Radiotherapy in the treatment of pituitary tumors. (2380090)
1990
50
Role of surgery in the management of pituitary tumors. (1967008)
1990

Genetic Variations for Pituitary Tumors

Expression for genes affiliated with Pituitary Tumors

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pituitary Tumors

Search GEO for disease gene expression data for Pituitary Tumors.

Pathways for genes affiliated with Pituitary Tumors

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database
See all sources

Pathways related to Pituitary Tumors according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.1GNAS, APC, ACVR1B, POMC, TRH, SST
2
Hide members
11.0GNAS, TSHB, POMC, TRH, SST, SSTR1

Compounds for genes affiliated with Pituitary Tumors

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Pituitary Tumors according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1acth4511.5GNAS, APC, GH1, PRL, SSTR5, SST
2octreotide45 60 29 1114.4POMC, GNAS, GH1, PRL, SSTR5, SSTR1
3ribonucleic acid4511.4GNAS, GH1, PRL, SSTR5, SSTR1, POMC
4norepinephrine45 11 2413.3GNAS, APC, GH1, PRL, SST, TRH
5dopamine45 29 11 2414.3GNAS, APC, SSTR5, SSTR1, TRH, PTTG1
6adenylate4511.3GNAS, APC, GH1, SSTR1, SST, TRH
7thyroxine45 2412.3GH1, PRL, SST, TRH, POMC, TSHB
8gnrh4511.2GNAS, GH1, PRL, SST, TRH, POMC
9lanreotide45 2912.2GH1, PRL, SSTR5, SSTR1, SST
10naloxone45 50 29 1114.2GH1, PRL, SST, TRH, POMC
11clonidine45 29 1113.2GH1, PRL, SST, TRH, POMC
12triiodothyronine4511.2GH1, PRL, TRH, POMC, TSHB
13thymidine45 2412.2GNAS, GH1, SSTR5, TRH, PTTG1, TSHB
14hydrocortisone45 2 60 1114.2GH1, PRL, SST, TRH, POMC
15ghrp4511.2GH1, PRL, SST, TRH
16bromocriptine29 45 1113.1POMC, TRH, SST, PRL
17hexarelin45 2912.1GH1, PRL, SST, POMC
18pyridostigmine45 1112.1GH1, PRL, SST, TRH
19progesterone45 60 29 11 2415.1GNAS, APC, GH1, PRL, TRH, POMC
20epinephrine45 11 2413.1APC, GH1, PRL, SST, POMC
21quinagolide4511.1GH1, PRL, SST
22pasireotide45 1112.1SSTR5, SSTR1, SST
23(1r,1s,3r/1r,1r,3s)-l-054,2646011.1SSTR5, SSTR1, SST
24levodopa45 1112.0GH1, PRL, SST, TRH
25cyclosomatostatin6011.0SSTR5, SSTR1, SST
26cyn 1548066011.0SSTR5, SSTR1, SST
27somatostatin60 2412.0SSTR5, SSTR1, SST
28111in-pentetreotide4511.0SSTR5, SSTR1, SST
295-hydroxytryptophan4511.0GH1, PRL, SST
30glucose4511.0POMC, TRH, APC
31sulpiride45 29 1113.0TRH, PRL, GH1
32domperidone45 29 1113.0PRL, SST, TRH
33testosterone45 60 11 2414.0APC, GH1, PRL, SST, TRH, POMC
34fenfluramine29 45 1113.0POMC, TRH, PRL
35metoclopramide45 1112.0TRH, PRL, GH1
36naltrexone45 50 29 1114.0POMC, PRL, GH1
37cabergoline29 45 1113.0GH1, PRL, SST
38estrogen4510.9TRH, PTTG1, TSHB
39l-817,8182910.9SSTR1, SSTR5
40pphp4510.9APC, GNAS
41apomorphine45 29 1112.9GH1, PRL, TRH
42somatuline4510.8SST, GH1
43bim 230502910.8SSTR1, SSTR5
44des-aa5-[d-trp8]srif2910.7SSTR5, SSTR1
45som-2302910.7SSTR5, SSTR1
46pitressin4510.7SST, POMC
47isoproterenol45 1111.6GNAS, APC, GH1, SST
48ke 1082910.6SSTR1, SSTR5
49forskolin45 50 1112.5POMC
50pertussis4510.4SST, GH1, APC

GO Terms for genes affiliated with Pituitary Tumors

Sources:
16Gene Ontology
See all sources

Cellular components related to Pituitary Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.9GH1, PRL, SST, TRH, POMC, TSHB
2secretory granuleGO:03014110.4POMC, TRH, PRL

Biological processes related to Pituitary Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromosome organizationGO:05127610.8PTTG2, PTTG1, PTTG3P, APC
2cell-cell signalingGO:00726710.8SSTR1, SST, TRH, POMC, TSHB
3peptide hormone processingGO:01648610.6TSHB, POMC
4response to nutrientGO:00758410.6SST, SSTR1, PRL
5positive regulation of JAK-STAT cascadeGO:04642710.3PRL, GH1

Molecular functions related to Pituitary Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.8TSHB, POMC, SST, PRL, GH1
2SH3 domain bindingGO:01712410.6PTTG2, PTTG1, PTTG3P
3prolactin receptor bindingGO:00514810.5GH1, PRL
4somatostatin receptor activityGO:00499410.3SSTR1, SSTR5

Products for genes affiliated with Pituitary Tumors

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  • Antibodies

Sources for Pituitary Tumors

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet