MCID: PTT037
MIFTS: 54

Pituitary Tumors malady

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Summaries for Pituitary Tumors

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MedlinePlus:33 Your pituitary gland is a pea-sized gland at the base of your brain. the pituitary is the "master control gland" - it makes hormones that affect growth and the functions of other glands in the body. pituitary tumors are common, but often they don't cause health problems. most people with pituitary tumors never even know they have them. the most common type of pituitary tumor produces hormones and disrupts the balance of hormones in your body. this can cause endocrine diseases such as cushing's syndrome and hyperthyroidism. symptoms of pituitary tumors include headaches vision problems nausea and vomiting problems caused by the production of too many hormones pituitary tumors are usually curable. treatment is often surgery to remove the tumor. other options include medicines, radiation therapy, and chemotherapy.

MalaCards based summary: Pituitary Tumors, also known as pituitary neoplasms, is related to pituitary carcinoma and pituitary apoplexy. An important gene associated with Pituitary Tumors is GNAS (GNAS complex locus), and among its related pathways are Transcription CREM signaling in testis and Hormone ligand-binding receptors. The drugs octreotide and octreotide acetate and the compounds [125i]tyr3 sms 201-995 and bim 23060 have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and hypothalamus, and related mouse phenotypes are endocrine/exocrine gland and behavior/neurological.

NINDS:43 The pituitary is a small, bean-sized gland that is below the hypothalamus, a structure at the base of the brain, by a thread-like stalk that contains both blood vessels and nerves.

Wikipedia:65 Pituitary adenomas are tumors that occur in the pituitary gland. Pituitary adenomas are generally... more...

Aliases & Classifications for Pituitary Tumors

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Sources:
43NINDS, 44Novoseek, 33MedlinePlus, 62UMLS
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Pituitary Tumors, Aliases & Descriptions:

Name: Pituitary Tumors 43 44 33
 
Pituitary Neoplasms 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Related Diseases for Pituitary Tumors

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Diseases related to Pituitary Tumors via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1pituitary carcinoma31.0PRL
2pituitary apoplexy30.9PRL
3mccune albright syndrome30.8GNAS
4acromegaly30.7GH1, SST, PRL
5amenorrhea30.5PRL
6meningioma30.3SSTR5, SSTR2, SST
7goiter30.2GNAS, TSHB
8craniopharyngioma30.2PRL, GH1, PROP1
9acth-secreting pituitary adenoma30.2GH1, PRL
10pituitary hypoplasia30.2GHRHR, PROP1, POU1F1
11pituitary gland disease30.2PRL, GH1
12empty sella syndrome30.1PROP1, POU1F1, PRL, GH1
13nelson syndrome30.0SST, PRL
14pancreatic cancer30.0SSTR2, SSTR5, SST, ACVR1B
15gigantism29.9PRL, GH1, SST, GNAS
16hyperprolactinemia29.8GNAS, SST, GH1, PRL
17panhypopituitarism29.7TSHB, PROP1, GH1, PRL, POU1F1
18hypoglycemia29.6PRL, SST, GH1
19hypogonadism29.5GH1, PRL, PROP1, POU1F1, FSHB
20growth hormone deficiency29.5POU1F1, GH1, GHRHR, PROP1, PRL
21hyperthyroidism29.3GNAS, TRHR, GH1, SST, PRL, TSHB
22breast cancer29.2GHRHR, GH1, SSTR2, PRL, SSTR5, POU1F1
23prolactinoma29.0PRL, SSTR5, SSTR2, GHRHR, GH1, GNAS
24hypothyroidism29.0PROP1, GNAS, POU1F1, TSHB, GH1, GHRHR
25adenoma28.6PROP1, PRL, TSHB, POU1F1, GNAS, FSHB
26pituitary adenoma28.5TRHR, GH1, GHRHR, SSTR2, SST, SSTR5
27thyroiditis10.6
28prolactin producing pituitary tumor10.5
29somatostatin analog10.5
30endotheliitis10.4
31osteomalacia10.4GNAS
32multiple endocrine neoplasia10.4
33growth hormone secreting pituitary adenoma10.3
34tsh producing pituitary tumor10.3
35retinoblastoma10.3
36esophagitis10.3
37thyroid cancer10.3
38headache10.3
39esophageal squamous cell carcinoma10.3
40oligospermia10.2FSHB, PRL
41fibrous dysplasia10.2GNAS, GH1
42isolated growth hormone deficiency type 1b10.2GHRHR, GH1
43retinitis10.2
44chromophobe adenoma10.2PRL, GH1
45congenital hypothyroidism10.2TSHB, POU1F1, GNAS
46hypothalamic disease10.2GH1, PRL
47endocrine gland cancer10.1SST, GNAS
48holoprosencephaly10.1POU1F1, PROP1
49isolated growth hormone deficiency10.1POU1F1, GH1
50somatostatinoma10.1SSTR2, SST

Graphical network of the top 20 diseases related to Pituitary Tumors:



Diseases related to pituitary tumors

Symptoms for Pituitary Tumors

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Drugs & Therapeutics for Pituitary Tumors

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Drug clinical trials:

Search ClinicalTrials for Pituitary Tumors

Search NIH Clinical Center for Pituitary Tumors

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Pituitary Tumors

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Anatomical Context for Pituitary Tumors

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MalaCards organs/tissues related to Pituitary Tumors:

32
Pituitary, Brain, Hypothalamus, Thyroid, Endothelial, Testes, Lung, Breast, Bone, Lymph node, Heart, Liver, Skin, Prostate, Testis, T cells

Animal Models for Pituitary Tumors or affiliated genes

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MGI Mouse Phenotypes related to Pituitary Tumors:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053797.6FSHB, GNAS, POU1F1, PRL, PROP1, SSTR5
2MP:00053867.5GNAS, PRL, PROP1, SSTR2, GHRHR, TRHR
3MP:00053897.1PRL, FSHB, ACVR1B, GH1, PROP1, POU1F1
4MP:00036317.0PROP1, GNAS, SST, SSTR2, POU1F1, ACVR1B
5MP:00053786.4SSTR5, PROP1, POU1F1, GNAS, GHRHR, GH1
6MP:00053766.0SST, GH1, GHRHR, GNAS, POU1F1, PRL

Publications for Pituitary Tumors

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Articles related to Pituitary Tumors:

(show top 50)    (show all 729)
idTitleAuthorsYear
1
Means, motive, and opportunity: SDH mutations are suspects in pituitary tumors. (23729015)
2013
2
Non-functioning pituitary tumors: 2012 update. (24035732)
2013
3
Challenge of Giant pituitary tumors. (24121298)
2013
4
State of art imaging of the pituitary tumors. (24343459)
2013
5
Pituitary tumor apoplexy presenting as infective meningoencephalitis. (21630035)
2012
6
Pituitary tumors in childhood. (22157404)
2012
7
Pituitary tumors in patients with MEN1 syndrome. (22584705)
2012
8
Endoscopic surgery of pituitary tumors. (21819880)
2011
9
Novel medical therapies for pituitary tumors. (20616507)
2010
10
Immunohistochemical expression of pituitary tumor transforming gene (PTTG) in pituitary adenomas: a correlative study of tumor subtypes. (20106827)
2010
11
Identification and consequences of galectin-3 expression in pituitary tumors. (20451577)
2010
12
Temozolomide treatment in aggressive pituitary tumors and pituitary carcinomas: a French multicenter experience. (20660056)
2010
13
Pituitary tumors: advances in neuroimaging. (19955765)
2010
14
The dopamine-somatostatin chimeric compound BIM-23A760 exerts antiproliferative and cytotoxic effects in human non-functioning pituitary tumors by activating ERK1/2 and p38 pathways. (19619936)
2010
15
Temozolomide treatment for aggressive pituitary tumors: correlation of clinical outcome with O(6)-methylguanine methyltransferase (MGMT) promoter methylation and expression. (20668043)
2010
16
The molecular biology of pituitary tumors: a personal perspective. (19058014)
2009
17
Pituitary tumor-transforming 1 increases cell motility and promotes lymph node metastasis in esophageal squamous cell carcinoma. (18451147)
2008
18
In vitro testing of new somatostatin analogs on pituitary tumor cells. (18243520)
2008
19
Activation of phosphatidylinositol 3-kinase signaling promotes aberrant pituitary growth in a mouse model of thyroid-stimulating hormone-secreting pituitary tumors. (18356276)
2008
20
Oct-1 induces pituitary tumor transforming gene expression in endocrine tumors. (18550719)
2008
21
Mechanisms for growth factor-induced pituitary tumor transforming gene-1 expression in pituitary folliculostellate TtT/GF cells. (16959877)
2006
22
Pituitary tumor-transforming gene expression is a prognostic marker for tumor recurrence in squamous cell carcinoma of the head and neck. (17029632)
2006
23
The 2004 World Health Organization classification of pituitary tumors: what is new? (16328527)
2006
24
Pituitary tumors arising from glycoprotein hormone alpha-subunit-deficient mice contain transcription factors and receptors present in thyrotropes. (16703404)
2006
25
A critical analysis of pituitary tumor shrinkage during primary medical therapy in acromegaly. (15827109)
2005
26
Classification and pathology of pituitary tumors. (16311407)
2005
27
Genetics and proteomics of pituitary tumors. (16311409)
2005
28
Quality of life in patients with pituitary tumors: a preliminary study. (12747133)
2003
29
Polysialylated neural cell adhesion molecules expressed in human pituitary tumors and related to extrasellar invasion. (12744370)
2003
30
Pituitary tumors and pregnancy. (12914726)
2003
31
Angiotensins II and IV stimulate the activity of tyrosine kinases in estrogen-induced rat pituitary tumors. (12359243)
2002
32
Incidence of a second tumor in hypopituitary patients operated for pituitary tumors. (11158027)
2001
33
Oncogene activation in pituitary tumors. (11414475)
2001
34
Genetic and histologic studies of somatomammotropic pituitary tumors in patients with the "complex of spotty skin pigmentation, myxomas, endocrine overactivity and schwannomas" (Carney complex). (11061550)
2000
35
Molecular pathogenesis of pituitary tumors. (10882539)
2000
36
Growth factors in pituitary tumors. (11081193)
1999
37
An abnormality of thyroid hormone receptor expression may explain abnormal thyrotropin production in thyrotropin-secreting pituitary tumors. (9492147)
1998
38
The alpha subunit of glycoprotein hormones as a biochemical marker of pituitary tumors]. (8553618)
1995
39
In vivo effect of cabergoline, a dopamine agonist, on estrogen-induced rat pituitary tumors. (7627259)
1995
40
Serum levels of beta-subunit of chorionic gonadotropin in patients with pituitary tumors. (7542981)
1995
41
Purine-binding factor (nm23) gene expression in pituitary tumors: marker of adenoma invasiveness. (7745027)
1995
42
The retinoblastoma gene in human pituitary tumors. (7690360)
1993
43
Modulation by glucocorticoids of growth hormone secretion in patients with different pituitary tumors. (8284031)
1993
44
Dopaminergic inhibition of DNA synthesis in pituitary tumor cells is associated with phosphotyrosine phosphatase activity. (1360008)
1992
45
Transforming DNA sequences present in human prolactin-secreting pituitary tumors. (1779971)
1991
46
Combined anterior pituitary function test using CRH, GRH, LH-RH, TRH and vasopressin in patients with non-functioning pituitary tumors. (2200236)
1990
47
Coexistence of low secretion of gonadotropins and ACTH in a patient with gonadal dysgenesis and pituitary tumor. (2167303)
1990
48
The in vitro and in vivo effects of human growth hormone administration on tumor growth of rats bearing a transplantable rat pituitary tumor (7315b). (2141483)
1990
49
Endocrine function in patients with large pituitary tumors treated with operative decompression and radiation therapy. (2927614)
1989
50
A case report of pituitary tumor presenting as Forbes-Albright syndrome: determination of pituitary prolactin content. (4168414)
1967

Variations for Pituitary Tumors

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Expression for genes affiliated with Pituitary Tumors

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Expression patterns in normal tissues for genes affiliated with Pituitary Tumors

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Pathways for genes affiliated with Pituitary Tumors

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Pathways related to Pituitary Tumors according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9GNAS, FSHB
29.9TSHB, FSHB
3
Show member pathways
9.7ACVR1B, FSHB, GNAS
4
Show member pathways
9.3SSTR2, SST, GNAS
5
Show member pathways
9.3GH1, FSHB, TSHB
69.3GHRHR, FSHB, TSHB, GNAS
7
Show member pathways
9.2GH1, GH2, GHRHR
8
Show member pathways
9.2GH1, PRL, GH2
99.2PRL, GH2, GH1
10
Show member pathways
Type III interferon signaling37
9.2PRL, GH2, GH1
11
Show member pathways
9.2GH2, PRL, GH1
12
Show member pathways
Peptide GPCRs37
9.1SSTR5, SSTR2, TRHR
13
Show member pathways
8.9GH2, ACVR1B, PRL, GH1
14
Show member pathways
6.0TSHB, FSHB, PRL, SST, GNAS, SSTR5
15
Show member pathways
5.7SSTR5, SST, FSHB, GH1, PRL, TSHB

Compounds for genes affiliated with Pituitary Tumors

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Compounds related to Pituitary Tumors according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1[125i]tyr3 sms 201-9952810.3SSTR2, SSTR5
2bim 230602810.3SSTR5, SSTR2
3bim 230592810.2SSTR2, SSTR5
4noc-ate2810.2SSTR5, SSTR2
5[111in,90y]dota-lan2810.2SSTR5, SSTR2
6[111in,90y]dota-toc2810.2SSTR2, SSTR5
7mk-6782810.1SSTR2, SSTR5
8bim 231972810.1SSTR5, SSTR2
9[111in]dota-boc-ate2810.1SSTR2, SSTR5
10bim 230232810.0SSTR2, SSTR5
11[111in]dota-noc289.9SSTR2, SSTR5
12[111in,90y]dota-noc289.9SSTR2, SSTR5
13[111in]dota-noc-ate289.8SSTR2, SSTR5
14tyr-3-octreotide449.8SSTR2, SST
15pasireotide44 1110.7SSTR2, SST, SSTR5
16(1r,1s,3r/1r,1r,3s)-l-054,264619.7SSTR2, SSTR5, SST
17cyn 154806619.7SSTR2, SSTR5, SST
18cyclosomatostatin619.7SST, SSTR2, SSTR5
19vapreotide44 28 1111.7SST, SSTR2, SSTR5
20111in-pentetreotide449.7SST, SSTR2, SSTR5
21somatostatin61 2410.7SSTR5, SSTR2, SST
22bim 23030289.6SSTR2, SSTR5
23leuprolide acetate449.6PRL, FSHB, GH1
24clomiphene citrate449.6PRL, GH1, FSHB
25buserelin44 28 1111.5SST, FSHB, PRL
26somatuline449.5SST, GH1
27quinagolide449.4GH1, PRL, SST
285-hydroxytryptophan449.3GH1, SST, PRL
29pyridostigmine44 1110.3PRL, SST, GH1
30cabergoline44 28 1111.3GH1, SST, PRL
31ghrp449.0PRL, SST, GHRHR, GH1
32hexarelin44 2810.0GH1, SST, GHRHR, PRL
33forskolin44 50 1111.0GNAS, POU1F1, SSTR2, GH1, GHRHR
34thyroxine44 249.9PRL, TSHB, GH1, SST
35bromocriptine44 28 1110.9SST, GH1, PRL, POU1F1
36lanreotide44 289.8SSTR2, GH1, SSTR5, PRL, SST
37thymidine44 249.8SSTR5, TSHB, POU1F1, GNAS, SSTR2, GH1
38progesterone44 28 61 24 1112.7SSTR2, FSHB, PRL, POU1F1, GNAS, GH1
39steroid448.7POU1F1, PRL, PROP1, FSHB, GNAS, GH1
40octreotide44 61 28 1111.6GNAS, SSTR5, PRL, SST, SSTR2, GH1
41isoproterenol44 119.6SST, TRHR, GNAS, GH1
42adenylate448.6GNAS, GH1, GHRHR, SSTR2, SST, FSHB
43estrogen448.5FSHB, PRL, TSHB, POU1F1, SSTR2, GH1
44testosterone44 61 24 1111.3PROP1, PRL, GH2, FSHB, GH1, SST
45gnrh448.3PRL, GH1, SSTR2, SST, FSHB, PROP1
46arginine448.2POU1F1, SST, GHRHR, GH1, PRL, GNAS
47dopamine44 28 24 1111.1SSTR2, GNAS, PRL, SSTR5, SST, GH1
48glucose448.1SST, PRL, SSTR2, GHRHR, GH2, GH1
49ribonucleic acid447.4GHRHR, GH2, GH1, SSTR2, SSTR5, GNAS
50acth447.3SSTR5, POU1F1, GNAS, GH1, SSTR2, SST

GO Terms for genes affiliated with Pituitary Tumors

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Cellular components related to Pituitary Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.7GH1, GH2, SST, FSHB, PRL, TSHB

Biological processes related to Pituitary Tumors according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1activation of adenylate cyclase activityGO:00719010.0GHRHR, GNAS
2peptide hormone processingGO:01648610.0TSHB, FSHB
3positive regulation of cAMP biosynthetic processGO:03081910.0GHRHR, GNAS
4somatotropin secreting cell developmentGO:06013310.0POU1F1, GHRHR
5adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.9GHRHR, GNAS
6determination of adult lifespanGO:0083409.9GHRHR, POU1F1
7positive regulation of insulin-like growth factor receptor signaling pathwayGO:0435689.8GHRHR, GH1
8female pregnancyGO:0075659.8PRL, FSHB, GNAS
9positive regulation of JAK-STAT cascadeGO:0464279.7PRL, GH1
10G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.6SSTR2, SSTR5
11lactationGO:0075959.6PRL, GHRHR
12JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.5GH2, PRL, GH1
13positive regulation of multicellular organism growthGO:0400189.5GH1, GHRHR, POU1F1
14cell-cell signalingGO:0072679.3SSTR2, TSHB, SST
15positive regulation of transcription from RNA polymerase II promoterGO:0459449.2POU1F1, PROP1, FSHB, ACVR1B
16negative regulation of cell proliferationGO:0082859.1POU1F1, SSTR5, SST, SSTR2
17G-protein coupled receptor signaling pathwayGO:0071868.7TRHR, SST, SSTR5, TSHB

Molecular functions related to Pituitary Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor bindingGO:0198389.9GHRHR, ACVR1B
2somatostatin receptor activityGO:0049949.6SSTR2, SSTR5
3prolactin receptor bindingGO:0051489.4GH1, PRL
4hormone activityGO:0051797.9SST, TSHB, GH1, GH2, PRL, FSHB

Products for genes affiliated with Pituitary Tumors

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Sources for Pituitary Tumors

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet