MCID: PTT037
MIFTS: 54

Pituitary Tumors malady

Cancer diseases category

Summaries for Pituitary Tumors

About this section
Sources:
35MedlinePlus, 45NINDS, 66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
MedlinePlus:35 Your pituitary gland is a pea-sized gland at the base of your brain. the pituitary is the "master control gland" - it makes hormones that affect growth and the functions of other glands in the body. pituitary tumors are common, but often they don't cause health problems. most people with pituitary tumors never even know they have them. the most common type of pituitary tumor produces hormones and disrupts the balance of hormones in your body. this can cause endocrine diseases such as cushing's syndrome and hyperthyroidism. symptoms of pituitary tumors include headaches vision problems nausea and vomiting problems caused by the production of too many hormones pituitary tumors are usually curable. treatment is often surgery to remove the tumor. other options include medicines, radiation therapy, and chemotherapy.

MalaCards: Pituitary Tumors, also known as pituitary neoplasms, is related to acromegaly and pituitary carcinoma. An important gene associated with Pituitary Tumors is GNAS (GNAS complex locus), and among its related pathways are Transcription CREM signaling in testis and Hormone ligand-binding receptors. The drugs octreotide and octreotide acetate and the compounds [125i]tyr3 sms 201-995 and bim 23059 have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and hypothalamus, and related mouse phenotypes are endocrine/exocrine gland and behavior/neurological.

NINDS:45 The pituitary is a small, bean-sized gland that is below the hypothalamus, a structure at the base of the brain, by a thread-like stalk that contains both blood vessels and nerves.

Wikipedia:66 Pituitary adenomas are noncancerous tumors that occur in the pituitary gland. Pituitary adenomas are... more...

Aliases & Classifications for Pituitary Tumors

About this section
Sources:
45NINDS, 46Novoseek, 35MedlinePlus, 63UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

pituitary tumors 45 46 35
pituitary neoplasms 63


Related Diseases for Pituitary Tumors

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Pituitary Tumors via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1acromegaly30.8GH1, SST, PRL
2pituitary carcinoma30.4PRL
3pituitary apoplexy30.4PRL
4adenoma30.3PROP1, PRL, TSHB, POU1F1, GNAS, FSHB
5prolactinoma30.3PRL, SSTR5, SSTR2, GHRHR, GH1, GNAS
6meningioma30.3SSTR5, SSTR2, SST
7pituitary adenoma30.3TRHR, GH1, GHRHR, SSTR2, SST, SSTR5
8empty sella syndrome30.2PROP1, POU1F1, PRL, GH1
9gigantism30.2PRL, GH1, SST, GNAS
10craniopharyngioma30.1PRL, GH1, PROP1
11mccune albright syndrome30.1GNAS
12pancreatic cancer30.1SSTR2, SSTR5, SST, ACVR1B
13amenorrhea30.0PRL
14hyperthyroidism30.0GNAS, TRHR, GH1, SST, PRL, TSHB
15hyperprolactinemia30.0GNAS, SST, GH1, PRL
16panhypopituitarism30.0TSHB, PROP1, GH1, PRL, POU1F1
17goiter30.0GNAS, TSHB
18acth-secreting pituitary adenoma30.0GH1, PRL
19pituitary hypoplasia30.0GHRHR, PROP1, POU1F1
20pituitary gland disease30.0PRL, GH1
21nelson syndrome29.9SST, PRL
22hypothyroidism29.8PROP1, GNAS, POU1F1, TSHB, GH1, GHRHR
23hypoglycemia29.8PRL, SST, GH1
24hypogonadism29.8GH1, PRL, PROP1, POU1F1, FSHB
25growth hormone deficiency29.8POU1F1, GH1, GHRHR, PROP1, PRL
26breast cancer29.7GHRHR, GH1, SSTR2, PRL, SSTR5, POU1F1
27thyroiditis10.6
28prolactin producing pituitary tumor10.5
29somatostatin analog10.5
30endotheliitis10.4
31multiple endocrine neoplasia10.4
32growth hormone secreting pituitary adenoma10.3
33tsh producing pituitary tumor10.3
34retinoblastoma10.3
35esophagitis10.3
36thyroid cancer10.3
37headache10.2
38esophageal squamous cell carcinoma10.2
39retinitis10.2
40osteomalacia10.1GNAS
41diabetes insipidus10.1
42scotoma10.1
43exophthalmos10.1
44astrocytoma10.1
45hepatocellular carcinoma10.1
46hormone producing pituitary cancer10.1
47multiple myeloma10.1
48myeloma10.1
49ovarian disease10.1
50pancreatitis10.1

Graphical network of the top 20 diseases related to Pituitary Tumors:



Diseases related to pituitary tumors

Symptoms for Pituitary Tumors

About this section

Drugs & Therapeutics for Pituitary Tumors

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pituitary Tumors

Drug clinical trials:

Search ClinicalTrials for Pituitary Tumors

Search NIH Clinical Center for Pituitary Tumors

Search CenterWatch for Pituitary Tumors

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Pituitary Tumors

About this section

Anatomical Context for Pituitary Tumors

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Pituitary Tumors:

34
Pituitary, Brain, Hypothalamus, Thyroid, Endothelial, Testes, Lung, Breast, Prostate, T cells, Testis, Skin, Liver, Heart, Lymph node, Bone

Animal Models for Pituitary Tumors or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Pituitary Tumors:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053797.6GH1, GNAS, POU1F1, PRL, PROP1, FSHB
2MP:00053867.5PRL, PROP1, SST, SSTR2, GHRHR, TRHR
3MP:00053897.1POU1F1, PRL, PROP1, FSHB, ACVR1B, GHRHR
4MP:00036317.0GNAS, POU1F1, PRL, PROP1, SST, SSTR2
5MP:00053786.4GNAS, POU1F1, PROP1, SSTR5, SST, ACVR1B
6MP:00053766.0GNAS, POU1F1, PRL, PROP1, FSHB, SSTR5

Publications for Pituitary Tumors

About this section
Sources:
53PubMed
See all sources

Articles related to Pituitary Tumors:

(show top 50)    (show all 713)
idTitleAuthorsYear
1
Means, motive, and opportunity: SDH mutations are suspects in pituitary tumors. (23729015)
2013
2
Non-functioning pituitary tumors: 2012 update. (24035732)
2013
3
Challenge of Giant pituitary tumors. (24121298)
2013
4
Pituitary tumor apoplexy presenting as infective meningoencephalitis. (21630035)
2012
5
Pituitary tumors in childhood. (22157404)
2012
6
Pituitary tumors in patients with MEN1 syndrome. (22584705)
2012
7
Endoscopic surgery of pituitary tumors. (21819880)
2011
8
Novel medical therapies for pituitary tumors. (20616507)
2010
9
Immunohistochemical expression of pituitary tumor transforming gene (PTTG) in pituitary adenomas: a correlative study of tumor subtypes. (20106827)
2010
10
Identification and consequences of galectin-3 expression in pituitary tumors. (20451577)
2010
11
Temozolomide treatment in aggressive pituitary tumors and pituitary carcinomas: a French multicenter experience. (20660056)
2010
12
Pituitary tumors: advances in neuroimaging. (19955765)
2010
13
The dopamine-somatostatin chimeric compound BIM-23A760 exerts antiproliferative and cytotoxic effects in human non-functioning pituitary tumors by activating ERK1/2 and p38 pathways. (19619936)
2010
14
Temozolomide treatment for aggressive pituitary tumors: correlation of clinical outcome with O(6)-methylguanine methyltransferase (MGMT) promoter methylation and expression. (20668043)
2010
15
The molecular biology of pituitary tumors: a personal perspective. (19058014)
2009
16
Pituitary tumor-transforming 1 increases cell motility and promotes lymph node metastasis in esophageal squamous cell carcinoma. (18451147)
2008
17
Expression of pituitary tumor-transforming gene in endometrial cancer as a prognostic marker. (18217976)
2008
18
In vitro testing of new somatostatin analogs on pituitary tumor cells. (18243520)
2008
19
Activation of phosphatidylinositol 3-kinase signaling promotes aberrant pituitary growth in a mouse model of thyroid-stimulating hormone-secreting pituitary tumors. (18356276)
2008
20
Oct-1 induces pituitary tumor transforming gene expression in endocrine tumors. (18550719)
2008
21
Mechanisms for growth factor-induced pituitary tumor transforming gene-1 expression in pituitary folliculostellate TtT/GF cells. (16959877)
2006
22
Pituitary tumor-transforming gene expression is a prognostic marker for tumor recurrence in squamous cell carcinoma of the head and neck. (17029632)
2006
23
The 2004 World Health Organization classification of pituitary tumors: what is new? (16328527)
2006
24
Pituitary tumors arising from glycoprotein hormone alpha-subunit-deficient mice contain transcription factors and receptors present in thyrotropes. (16703404)
2006
25
A critical analysis of pituitary tumor shrinkage during primary medical therapy in acromegaly. (15827109)
2005
26
Classification and pathology of pituitary tumors. (16311407)
2005
27
Genetics and proteomics of pituitary tumors. (16311409)
2005
28
Quality of life in patients with pituitary tumors: a preliminary study. (12747133)
2003
29
Polysialylated neural cell adhesion molecules expressed in human pituitary tumors and related to extrasellar invasion. (12744370)
2003
30
Pituitary tumors and pregnancy. (12914726)
2003
31
Angiotensins II and IV stimulate the activity of tyrosine kinases in estrogen-induced rat pituitary tumors. (12359243)
2002
32
Incidence of a second tumor in hypopituitary patients operated for pituitary tumors. (11158027)
2001
33
Oncogene activation in pituitary tumors. (11414475)
2001
34
Genetic and histologic studies of somatomammotropic pituitary tumors in patients with the "complex of spotty skin pigmentation, myxomas, endocrine overactivity and schwannomas" (Carney complex). (11061550)
2000
35
Molecular pathogenesis of pituitary tumors. (10882539)
2000
36
Growth factors in pituitary tumors. (11081193)
1999
37
An abnormality of thyroid hormone receptor expression may explain abnormal thyrotropin production in thyrotropin-secreting pituitary tumors. (9492147)
1998
38
The alpha subunit of glycoprotein hormones as a biochemical marker of pituitary tumors]. (8553618)
1995
39
In vivo effect of cabergoline, a dopamine agonist, on estrogen-induced rat pituitary tumors. (7627259)
1995
40
Serum levels of beta-subunit of chorionic gonadotropin in patients with pituitary tumors. (7542981)
1995
41
Purine-binding factor (nm23) gene expression in pituitary tumors: marker of adenoma invasiveness. (7745027)
1995
42
The retinoblastoma gene in human pituitary tumors. (7690360)
1993
43
Modulation by glucocorticoids of growth hormone secretion in patients with different pituitary tumors. (8284031)
1993
44
Dopaminergic inhibition of DNA synthesis in pituitary tumor cells is associated with phosphotyrosine phosphatase activity. (1360008)
1992
45
Transforming DNA sequences present in human prolactin-secreting pituitary tumors. (1779971)
1991
46
Combined anterior pituitary function test using CRH, GRH, LH-RH, TRH and vasopressin in patients with non-functioning pituitary tumors. (2200236)
1990
47
Coexistence of low secretion of gonadotropins and ACTH in a patient with gonadal dysgenesis and pituitary tumor. (2167303)
1990
48
The in vitro and in vivo effects of human growth hormone administration on tumor growth of rats bearing a transplantable rat pituitary tumor (7315b). (2141483)
1990
49
Endocrine function in patients with large pituitary tumors treated with operative decompression and radiation therapy. (2927614)
1989
50
A case report of pituitary tumor presenting as Forbes-Albright syndrome: determination of pituitary prolactin content. (4168414)
1967

Variations for Pituitary Tumors

About this section

Expression for genes affiliated with Pituitary Tumors

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pituitary Tumors

Search GEO for disease gene expression data for Pituitary Tumors.

Pathways for genes affiliated with Pituitary Tumors

About this section
Sources:
51PathCards, 61Thomson Reuters, 56Reactome, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN, 13EMD Millipore
See all sources

Pathways related to Pituitary Tumors according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9GNAS, FSHB
29.9TSHB, FSHB
3
Show member pathways
9.7ACVR1B, FSHB, GNAS
4
Show member pathways
9.3SSTR2, SST, GNAS
5
Show member pathways
9.3GH1, FSHB, TSHB
69.3GHRHR, FSHB, TSHB, GNAS
7
Show member pathways
9.2GH1, GH2, GHRHR
8
Show member pathways
9.2GH1, PRL, GH2
99.2PRL, GH2, GH1
10
Show member pathways
Type III interferon signaling39
9.2PRL, GH2, GH1
11
Show member pathways
9.2GH2, PRL, GH1
12
Show member pathways
Peptide GPCRs39
9.1SSTR5, SSTR2, TRHR
13
Show member pathways
8.9GH2, ACVR1B, PRL, GH1
14
Show member pathways
6.0TSHB, FSHB, PRL, SST, GNAS, SSTR5
15
Show member pathways
5.7SSTR5, SST, FSHB, GH1, PRL, TSHB

Compounds for genes affiliated with Pituitary Tumors

About this section
Sources:
30IUPHAR, 46Novoseek, 12DrugBank, 62Tocris Bioscience, 25HMDB, 52PharmGKB
See all sources

Compounds related to Pituitary Tumors according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1[125i]tyr3 sms 201-9953010.3SSTR5, SSTR2
2bim 230593010.3SSTR5, SSTR2
3bim 230603010.2SSTR5, SSTR2
4[111in,90y]dota-lan3010.2SSTR2, SSTR5
5noc-ate3010.2SSTR5, SSTR2
6[111in,90y]dota-toc3010.2SSTR2, SSTR5
7bim 230303010.1SSTR2, SSTR5
8[111in,90y]dota-oc3010.1SSTR5, SSTR2
9[111in]dota-boc-ate3010.1SSTR5, SSTR2
10bim 230233010.1SSTR2, SSTR5
11[111in]dota-noc3010.0SSTR2, SSTR5
12[111in]dota-noc-ate309.9SSTR2, SSTR5
13bim 23197309.9SSTR2, SSTR5
14mk-678309.8SSTR2, SSTR5
15tyr-3-octreotide469.8SSTR2, SST
16pasireotide46 1210.7SSTR2, SST, SSTR5
17(1r,1s,3r/1r,1r,3s)-l-054,264629.7SSTR2, SSTR5, SST
18cyn 154806629.7SSTR2, SSTR5, SST
19cyclosomatostatin629.7SST, SSTR2, SSTR5
20vapreotide46 30 1211.7SST, SSTR2, SSTR5
21111in-pentetreotide469.7SST, SSTR2, SSTR5
22somatostatin62 2510.7SSTR5, SSTR2, SST
23[111in,90y]dota-noc309.6SSTR2, SSTR5
24leuprolide acetate469.6PRL, GH1, FSHB
25clomiphene citrate469.6PRL, FSHB, GH1
26buserelin46 30 1211.5SST, FSHB, PRL
27quinagolide469.4GH1, PRL, SST
285-hydroxytryptophan469.3GH1, SST, PRL
29pyridostigmine46 1210.3PRL, SST, GH1
30cabergoline46 30 1211.3GH1, PRL, SST
31ghrp469.0PRL, SST, GHRHR, GH1
32hexarelin46 3010.0GH1, SST, GHRHR, PRL
33forskolin46 52 1211.0GNAS, SSTR2, POU1F1, GHRHR, GH1
34thyroxine46 259.9TSHB, PRL, SST, GH1
35bromocriptine46 30 1210.9SST, GH1, PRL, POU1F1
36lanreotide46 309.8SSTR2, GH1, SSTR5, PRL, SST
37thymidine46 259.8SSTR5, TSHB, POU1F1, GNAS, SSTR2, GH1
38progesterone46 30 62 25 1212.7SSTR2, FSHB, PRL, POU1F1, GNAS, GH1
39steroid468.7GH1, FSHB, PROP1, PRL, POU1F1, GNAS
40octreotide46 62 30 1211.6GNAS, SSTR5, PRL, SST, SSTR2, GH1
41isoproterenol46 129.6GH1, TRHR, GNAS, SST
42adenylate468.6GNAS, GH1, GHRHR, SSTR2, SST, FSHB
43estrogen468.5FSHB, GH1, POU1F1, TSHB, PRL, SSTR2
44testosterone46 62 25 1211.3GH2, SST, PRL, PROP1, FSHB, GH1
45gnrh468.3PRL, GH1, SSTR2, SST, FSHB, PROP1
46arginine468.2POU1F1, SST, GHRHR, PRL, GH1, GNAS
47dopamine46 30 25 1211.1SSTR2, GNAS, PRL, SSTR5, SST, GH1
48glucose468.1SST, PRL, SSTR2, GHRHR, GH2, GH1
49ribonucleic acid467.4GHRHR, GH2, GH1, SSTR2, SSTR5, GNAS
50acth467.3SSTR5, POU1F1, GNAS, GH1, SSTR2, SST

GO Terms for genes affiliated with Pituitary Tumors

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Pituitary Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.7GH1, GH2, SST, FSHB, PRL, TSHB

Biological processes related to Pituitary Tumors according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1activation of adenylate cyclase activityGO:00719010.0GNAS, GHRHR
2peptide hormone processingGO:01648610.0FSHB, TSHB
3positive regulation of cAMP biosynthetic processGO:03081910.0GHRHR, GNAS
4somatotropin secreting cell developmentGO:06013310.0GHRHR, POU1F1
5adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.9GHRHR, GNAS
6determination of adult lifespanGO:0083409.9POU1F1, GHRHR
7positive regulation of insulin-like growth factor receptor signaling pathwayGO:0435689.8GH1, GHRHR
8female pregnancyGO:0075659.8FSHB, PRL, GNAS
9positive regulation of JAK-STAT cascadeGO:0464279.7GH1, PRL
10G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.6SSTR5, SSTR2
11lactationGO:0075959.6PRL, GHRHR
12JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.5GH1, GH2, PRL
13positive regulation of multicellular organism growthGO:0400189.5POU1F1, GHRHR, GH1
14cell-cell signalingGO:0072679.3TSHB, SST, SSTR2
15positive regulation of transcription from RNA polymerase II promoterGO:0459449.2ACVR1B, FSHB, PROP1, POU1F1
16negative regulation of cell proliferationGO:0082859.1POU1F1, SSTR5, SST, SSTR2
17G-protein coupled receptor signaling pathwayGO:0071868.7TSHB, SSTR5, SST, TRHR

Molecular functions related to Pituitary Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor bindingGO:0198389.9GHRHR, ACVR1B
2somatostatin receptor activityGO:0049949.6SSTR2, SSTR5
3prolactin receptor bindingGO:0051489.4PRL, GH1
4hormone activityGO:0051797.9GH1, GH2, SST, FSHB, PRL, TSHB

Products for genes affiliated with Pituitary Tumors

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pituitary Tumors

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet