MCID: PTY001
MIFTS: 45

Pityriasis Rosea malady

Skin diseases category

Summaries for Pityriasis Rosea

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63Wikipedia, 32MalaCards
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Wikipedia:63 Pityriasis rosea (also known as pityriasis rosea Gibert) is a skin rash. It is benign but may inflict... more...

MalaCards: Pityriasis Rosea, also known as pityriasis circinata, is related to psoriasis and lichen planus. An important gene associated with Pityriasis Rosea is HLA-DRB4 (major histocompatibility complex, class II, DR beta 4), and among its related pathways are Classical antibody-mediated complement activation and COPII (Coat Protein 2) Mediated Vesicle Transport. The drugs methdilazine and methdilazine hydrochloride and the compounds dr-10 and ecori have been mentioned in the context of this disorder. Affiliated tissues include skin, bone marrow and bone.

Aliases & Classifications for Pityriasis Rosea

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

pityriasis rosea 8 60
pityriasis circinata 8


External Ids:

Disease Ontology8 DOID:8892
NCIt39 C26855
ICD9CM27 696.3
SNOMED-CT56 77252004, 156373006
MeSH34 D017515
ICD1025 L42

Related Diseases for Pityriasis Rosea

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17GeneCards, 18GeneDecks
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Diseases related to Pityriasis Rosea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1psoriasis30.7HLA-C, HLA-B, HLA-DRB1, HLA-A, CX3CL1
2lichen planus30.7IFNA2
3hepatitis30.5IFNA2, HLA-DRB1, HLA-A
4influenza30.4HLA-A, HLA-B
5hepatitis b30.4HLA-DRB1, HLA-DQB1, IFNA2
6stomatitis30.2IFNA2
7aphthous stomatitis30.2HLA-B
8skin disease30.2HLA-DRB1
9multiple sclerosis30.2HLA-DRB1, HLA-DQB1
10hepatitis c30.2IFNA2, HLA-DRB1, HLA-A
11arthritis30.2HLA-C, HLA-B, HLA-DRB1, HLA-A
12rheumatoid arthritis30.2HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1, HLA-A, CX3CL1
13dermatitis10.5
14syphilis10.4
15erythema multiforme10.3
16pityriasis versicolor10.3
17secondary syphilis10.3
18herpes simplex10.3
19pityriasis rotunda10.2
20bruxism10.2
21bell's palsy10.2
22atopic dermatitis10.2
23parapsoriasis10.2
24polyarteritis nodosa10.2
25herpes zoster10.2
26epidermolysis bullosa dystrophica10.2
27hepatitis a10.2
28allergic contact dermatitis10.2
29contact dermatitis10.2
30cutaneous mastocytosis10.2
31dermatitis herpetiformis10.2
32epidermolysis bullosa10.2
33exanthem10.2
34histiocytosis10.2
35keratosis10.2
36lichen disease10.2
37nephrotic syndrome10.2
38pneumonia10.2
39smallpox10.2
40dementia10.0CX3CL1
41peyronies disease10.0IFNA2
42visceral leishmaniasis10.0PKD2L1
43vitiligo10.0HLA-B
44measles10.0HLA-A
45cryoglobulinemic vasculitis10.0IFNA2
46myositis10.0HLA-B
47focal epithelial hyperplasia10.0IFNA2
48endometriosis10.0HLA-A
49polymyositis10.0HLA-B
50splenomegaly10.0IFNA2

Graphical network of the top 20 diseases related to Pityriasis Rosea:



Diseases related to pityriasis rosea

Clinical Features for Pityriasis Rosea

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Drugs & Therapeutics for Pityriasis Rosea

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pityriasis Rosea

Drug clinical trials:

Search ClinicalTrials for Pityriasis Rosea

Search NIH Clinical Center for Pityriasis Rosea

Search CenterWatch for Pityriasis Rosea

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Pityriasis Rosea

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Anatomical Context for Pityriasis Rosea

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32MalaCards
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MalaCards organs/tissues related to Pityriasis Rosea:

32
Skin, Bone marrow, Bone, Testes, Myeloid, T cells, Tongue

Animal Models for Pityriasis Rosea or affiliated genes

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Publications for Pityriasis Rosea

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50PubMed
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Articles related to Pityriasis Rosea:

(show top 50)    (show all 342)
idTitleAuthorsYear
1
Low dose of acyclovir may be an effective treatment against pityriasis rosea: a random investigator-blind clinical trial on 64 patients. (20477925)
2011
2
A novel influenza a (H1N1) virus as a possible cause of pityriasis rosea? A comment. (21585559)
2011
3
A novel influenza a (H1N1) virus as a possible cause of pityriasis rosea? (20561127)
2011
4
Pityriasis rosea showing unilateral localization. (21352292)
2011
5
Childhood Pityriasis rosea inversa without Herald Patch Mimicking Cutaneous Mastocytosis. (23056712)
2010
6
Increased serum levels of interleukin-22 in patients affected by pityriasis rosea. (19646140)
2009
7
Plantar herald patch in pityriasis rosea. (19187313)
2009
8
Blaschkoid pityriasis rosea. (19836654)
2009
9
Pityriasis rosea during etanercept therapy. (19961045)
2009
10
Pityriasis rosea occurring during acyclovir therapy. (17558061)
2007
11
The CX3C-chemokine fractalkine (CX3CL1) is detectable in serum of patients affected by active pityriasis rosea. (17062081)
2006
12
Use of high-dose acyclovir in pityriasis rosea. (16384760)
2006
13
The detection of human herpesvirus-8 DNA in plasma and peripheral blood mononuclear cells in adult patients with pityriasis rosea by polymerase chain reaction. (16836493)
2006
14
Investigation of herpes simplex virus DNA in pityriasis rosea by polymerase chain reaction. (15941434)
2005
15
Appearance of pityriasis rosea in patients with dark skin. (15368720)
2004
16
Pityriasis rosea. (14727822)
2004
17
Information from your family doctor. Pityriasis rosea. (14727823)
2004
18
'Pityriasis rosea-like' adverse reaction to lisinopril. (15482318)
2004
19
Should we still use phototherapy for Pityriasis rosea? (12914603)
2003
20
A prospective case control study of autoimmune markers in patients with pityriasis rosea. (12823314)
2003
21
Pityriasis rosea-like eruption due to pneumococcal vaccine in a child with nephrotic syndrome. (12692364)
2003
22
Rash orientation in pityriasis rosea: a qualitative study. (11978566)
2002
23
Long-lasting "christmas tree rash" in an adolescent: isotopic response of indeterminate cell histiocytosis in pityriasis rosea? (12361135)
2002
24
Lack of evidence of active human herpesvirus 7 (HHV-7) infection in three cases of pityriasis rosea in children. (11737679)
2001
25
Serum antibodies to parvovirus B19 in patients with pityriasis rosea. (9252763)
1997
26
Atypical pityriasis rosea in a 2-year-old. (7792225)
1995
27
HLA-DR antigen expression on peripheral T cell subsets in pityriasis rosea and herpes zoster. (1831772)
1991
28
An epidemiological study of pityriasis rosea in Middle Road Hospital. (2595391)
1989
29
Does a condition like human pityriasis rosea occur in pigs? (3706672)
1986
30
Pityriasis rosea Gibert and Mycoplasma pneumoniae infection. (3926847)
1985
31
Treatment of pityriasis rosea with UV radiation. (6847217)
1983
32
Case clustering in pityriasis rosea: support for role of an infective agent. (6802375)
1982
33
Case clustering in pityriasis rosea: support for role of an infective agent. (6800463)
1982
34
Virus-like particles in the herald patch of pityriasis rosea. (7227609)
1981
35
Pityriasis rosea in a patient with epidermolysis bullosa dystrophica. (479433)
1979
36
Pityriasis rosea in infancy. (453907)
1979
37
Pityriasis rosea-like drug eruption secondary to metronidazole. (911179)
1977
38
Pityriasis rosea in sisters. (4700024)
1973
39
Pityriasis rosea in pigs. (5257574)
1969
40
Pityriasis rosea. (6053968)
1967
41
Localized pityriasis rosea. (14450139)
1961
42
Does the tanned skin prevent eruption of pityriasis rosea? (13443506)
1957
43
Pityriasis rosea sparing tanned areas of skin; a report of two cases. (18865727)
1948
44
Case of Pityriasis Rosea with Unusual Features. (19979967)
1918
45
A Syphilide with Resemblances to Pityriasis Rosea. (19979981)
1918
46
Discussion on Pityriasis Rosea. (19977610)
1914
47
Discussion on Pityriasis Rosea. (19977603)
1914
48
Discussion on Pityriasis Rosea. (19977608)
1914
49
Discussion on Pityriasis Rosea. (19977605)
1914
50
Pityriasis Rosea. (18733810)
1906

Genetic Variations for Pityriasis Rosea

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Expression for genes affiliated with Pityriasis Rosea

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pityriasis Rosea

Search GEO for disease gene expression data for Pityriasis Rosea.

Pathways for genes affiliated with Pityriasis Rosea

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Sources:
53Reactome, 29KEGG, 12EMD Millipore, 55SinoBiological, 51QIAGEN
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Pathways related to Pityriasis Rosea according to GeneCards/GeneDecks:

(show all 37)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.3HLA-A, HLA-B, HLA-C
2
Hide members
9.3HLA-A, HLA-B, HLA-C
39.3HLA-A, HLA-B, HLA-C
49.3HLA-A, HLA-B, HLA-C
59.3HLA-C, HLA-B, HLA-A
69.3HLA-C, HLA-B, HLA-A
7
Hide members
9.2HLA-C, HLA-DQB1, HLA-DRB5, HLA-A
8
Immune response IFN alpha/beta signaling pathway
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9.0IFNA2, HLA-C, HLA-B, HLA-A
9
Hide members
9.0IFNA2, HLA-C, HLA-B, HLA-A
108.7HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5
118.4HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DQB1
12
Hide members
8.4HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DQB1
138.4HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DQB1
14
Hide members
8.4HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DQB1
15
Immune response NFAT in immune response
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8.4HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DQB1
16
Hide members
8.4HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
17
Hide members
8.4HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
18
Hide members
8.4HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
198.4HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
20
Hide members
8.4HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
21
Hide members
8.4HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
228.4HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
23
Immune response Antigen presentation by MHC class II
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8.4HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
24
Hide members
8.4HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
25
Hide members
8.4HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
26
Immune response ICOS pathway in T-helper cell
Hide members
8.4HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
278.4HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
288.1IFNA2, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
297.2HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-B, HLA-DQB1
307.2HLA-C, HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB4, HLA-DRB3
317.2HLA-C, HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB4, HLA-DRB3
32
Hide members
7.2HLA-C, HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB4, HLA-DRB3
337.2HLA-C, HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB4, HLA-DRB3
34
Hide members
6.9IFNA2, HLA-C, HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB4
35
Hide members
6.9IFNA2, HLA-C, HLA-A, HLA-DRB1, HLA-DRB3, HLA-DRB4
36
Hide members
6.9HLA-A, IFNA2, HLA-C, HLA-DQB1, HLA-B, HLA-DRB5
37
Hide members
6.9IFNA2, HLA-C, HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB4

Compounds for genes affiliated with Pityriasis Rosea

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44Novoseek, 11DrugBank, 24HMDB
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Compounds related to Pityriasis Rosea according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1dr-10449.8HLA-A, HLA-DRB1
2ecori449.7HLA-B, HLA-DQB1
3busulfan44 1110.6IFNA2, HLA-B
4levamisole44 1110.5HLA-A, IFNA2
5ursodeoxycholic acid44 11 2411.4HLA-A, HLA-B, IFNA2

GO Terms for genes affiliated with Pityriasis Rosea

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Sources:
16Gene Ontology
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Cellular components related to Pityriasis Rosea according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1MHC class I protein complexGO:0426129.5HLA-A, HLA-B, HLA-C
2early endosome membraneGO:0319019.3HLA-A, HLA-B, HLA-C
3phagocytic vesicle membraneGO:0306709.2HLA-C, HLA-B, HLA-A
4late endosome membraneGO:0319028.8HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
5external side of plasma membraneGO:0098978.7HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
6MHC class II protein complexGO:0426138.7HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
7clathrin-coated endocytic vesicle membraneGO:0306698.7HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
8transport vesicle membraneGO:0306588.6HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
9trans-Golgi network membraneGO:0325888.6HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
10endocytic vesicle membraneGO:0306668.6HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
11lysosomal membraneGO:0057658.5HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
12ER to Golgi transport vesicle membraneGO:0125077.5HLA-A, HLA-C, HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB4
13integral to lumenal side of endoplasmic reticulum membraneGO:0715567.5HLA-C, HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB4, HLA-DRB3
14integral to plasma membraneGO:0058877.5HLA-C, HLA-B, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-A
15Golgi membraneGO:0001397.5HLA-C, HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB4, HLA-DRB3
16plasma membraneGO:0058866.2HLA-C, HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB4, HLA-DRB3

Biological processes related to Pityriasis Rosea according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:0024809.4HLA-C, HLA-B, HLA-A
2positive regulation of T cell mediated cytotoxicityGO:0019169.4HLA-C, HLA-B, HLA-A
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:0024799.3HLA-A, HLA-B, HLA-C
4antigen processing and presentation of peptide antigen via MHC class IGO:0024749.3HLA-A, HLA-B, HLA-C
5antigen processing and presentation of exogenous peptide antigen via MHC class IGO:0425909.2HLA-C, HLA-B, HLA-A
6type I interferon-mediated signaling pathwayGO:0603379.1HLA-A, HLA-B, HLA-C, IFNA2
7regulation of interleukin-10 secretionGO:20011799.0HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
8regulation of interleukin-4 productionGO:0326739.0HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
9regulation of immune responseGO:0507769.0HLA-A, HLA-B, HLA-C
10T-helper 1 type immune responseGO:0420889.0HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
11inflammatory response to antigenic stimulusGO:0024379.0HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
12positive regulation of insulin secretion involved in cellular response to glucose stimulusGO:0357749.0HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5
13negative regulation of interferon-gamma productionGO:0326898.9HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5
14negative regulation of T cell proliferationGO:0421308.9HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
15protein tetramerizationGO:0512628.9HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5
16immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023818.7HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
17humoral immune response mediated by circulating immunoglobulinGO:0024558.7HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
18T cell costimulationGO:0312958.7HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
19T cell receptor signaling pathwayGO:0508528.6HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
20antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198868.6HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
21detection of bacteriumGO:0160458.2HLA-A, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-B
22interferon-gamma-mediated signaling pathwayGO:0603337.6HLA-DRB5, HLA-B, HLA-DQB1, HLA-C, HLA-DRB4, HLA-DRB3
23immune responseGO:0069557.0HLA-C, HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB4, HLA-DRB3
24cytokine-mediated signaling pathwayGO:0192216.7CX3CL1, HLA-A, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5

Molecular functions related to Pityriasis Rosea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051028.8CX3CL1, HLA-A, HLA-B, HLA-C
2MHC class II receptor activityGO:0323958.4HLA-DQB1, HLA-DRB4, HLA-DRB3, HLA-DRB1
3peptide antigen bindingGO:0426057.4HLA-A, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-B

Products for genes affiliated with Pityriasis Rosea

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Sources for Pityriasis Rosea

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet