MCID: PTY001
MIFTS: 48

Pityriasis Rosea malady

Skin diseases category

Summaries for Pityriasis Rosea

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66Wikipedia, 34MalaCards
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Wikipedia:66 Pityriasis rosea (also known as pityriasis rosea Gibert) is a skin rash. It is benign but may inflict... more...

MalaCards: Pityriasis Rosea, also known as pityriasis circinata, is related to hepatitis and psoriasis. An important gene associated with Pityriasis Rosea is HLA-DRB4 (major histocompatibility complex, class II, DR beta 4), and among its related pathways are Type II interferon signaling (IFNG) and TCR signaling in naive CD4+ T cells. The drugs methdilazine and methdilazine hydrochloride and the compounds levamisole and dr-10 have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and bone.

Aliases & Classifications for Pityriasis Rosea

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9Disease Ontology, 63UMLS, 59SNOMED-CT, 41NCIt, 28ICD9CM, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

pityriasis rosea 9 63
pityriasis circinata 9


External Ids:

Disease Ontology9 DOID:8892
NCIt41 C26855
ICD9CM28 696.3
SNOMED-CT59 77252004, 156373006
MeSH36 D017515
ICD1026 L42

Related Diseases for Pityriasis Rosea

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Pityriasis Rosea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 91)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis30.6HLA-B, HLA-A, IFNA2
2psoriasis30.6CX3CL1, HLA-DRB1, HLA-C, HLA-A, HLA-B
3hepatitis b30.5IFNA2, HLA-DRB1, HLA-DQB1
4polyarteritis nodosa30.5IFNA2
5hepatitis c30.2IFNA2, HLA-DRB1, HLA-A
6arthritis30.1HLA-B, HLA-A, HLA-C, HLA-DRB1
7rheumatoid arthritis30.1HLA-A, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1, CX3CL1
8multiple sclerosis30.0HLA-B, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5, HLA-DRB1
9dermatitis10.6
10lichen planus10.4
11syphilis10.4
12pityriasis rotunda10.4
13secondary syphilis10.3
14erythema multiforme10.3
15herpes simplex10.3
16influenza10.3
17blindness10.3
18bruxism10.2
19aphthous stomatitis10.2
20herpes zoster10.2
21bell's palsy10.2
22atopic dermatitis10.2
23parapsoriasis10.2
24epidermolysis bullosa dystrophica10.2
25allergic contact dermatitis10.2
26contact dermatitis10.2
27cutaneous mastocytosis10.2
28dermatitis herpetiformis10.2
29epidermolysis bullosa10.2
30exanthem10.2
31histiocytosis10.2
32nephrotic syndrome10.2
33pneumonia10.2
34skin disease10.2
35smallpox10.2
36stomatitis10.2
37guttate psoriasis10.2
38mastocytosis10.2
39pityriasis lichenoides10.2
40pityriasis lichenoides et varioliformis acuta10.2
41hepatitis c virus10.2
42indeterminate cell histiocytosis10.2
43focal epithelial hyperplasia10.1IFNA2
44narcolepsy10.1HLA-DRB1
45autoimmune thyroiditis10.0HLA-DRB4, HLA-B
46human immunodeficiency virus infectious disease10.0HLA-A, HLA-C
47primary sclerosing cholangitis10.0HLA-A, HLA-C
48myasthenia gravis10.0HLA-B, HLA-DQB1
49thyroiditis10.0HLA-C, HLA-DRB1
50autoimmune thrombocytopenic purpura10.0IFNA2, HLA-DRB1

Graphical network of the top 20 diseases related to Pityriasis Rosea:



Diseases related to pityriasis rosea

Symptoms for Pityriasis Rosea

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Drugs & Therapeutics for Pityriasis Rosea

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Pityriasis Rosea

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Pityriasis Rosea

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Anatomical Context for Pityriasis Rosea

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34MalaCards
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MalaCards organs/tissues related to Pityriasis Rosea:

34
Skin, Tongue, Bone, Testes, Bone marrow, Myeloid, T cells

Animal Models for Pityriasis Rosea or affiliated genes

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Publications for Pityriasis Rosea

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Sources:
53PubMed
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Articles related to Pityriasis Rosea:

(show top 50)    (show all 335)
idTitleAuthorsYear
1
Polymorphic pityriasis rosea precipitating psoriasis. (23437430)
2013
2
Palmar herald patch in pityriasis rosea. (22881477)
2012
3
Low dose of acyclovir may be an effective treatment against pityriasis rosea: a random investigator-blind clinical trial on 64 patients. (20477925)
2011
4
Pityriasis rosea-like Drug Eruption Induced by Imatinib Mesylate (Gleeveca8c). (22346278)
2011
5
Pityriasis rosea in a woman and her husband - case report and review of the literature. (21399750)
2010
6
Childhood Pityriasis rosea inversa without Herald Patch Mimicking Cutaneous Mastocytosis. (23056712)
2010
7
Childhood pityriasis rosea. (20199459)
2009
8
Atypical Pityriasis rosea in a black child: a case report. (20181179)
2009
9
Pregnancy outcome in patients with pityriasis rosea. (18489054)
2008
10
Pityriasis rosea. (18297832)
2008
11
Study of role of streptococcal throat infection in pityriasis rosea. (19882027)
2008
12
Pityriasis rosea occurring during acyclovir therapy. (17558061)
2007
13
Purpuric pityriasis rosea-like eruption: a cutaneous marker of acute myeloid leukaemia. (17567315)
2007
14
Pityriasis rosea. (16948385)
2006
15
Macular eruption. Pityriasis rosea. (17044638)
2006
16
The CX3C-chemokine fractalkine (CX3CL1) is detectable in serum of patients affected by active pityriasis rosea. (17062081)
2006
17
Correlation between HLA and pityriasis rosea susceptibility in Brazilian blacks. (16405603)
2006
18
Is human herpesvirus 7 the causative agent of pityriasis rosea?--A critical review. (15569005)
2004
19
Avidity of antibodies to human herpesvirus 7 suggests primary infection in young adults with pityriasis rosea. (15482314)
2004
20
Pityriasis rosea unilateralis. (17642826)
2003
21
Rash orientation in pityriasis rosea: a qualitative study. (11978566)
2002
22
Human herpes virus-like particles in pityriasis rosea lesions: an electron microscopy study. (12135467)
2002
23
Association of pityriasis rosea with human herpesvirus-6 and human herpesvirus-7 in Taipei. (11579614)
2001
24
Pityriasis rosea associated with herpesvirus 7 DNA. (11204526)
2000
25
Peripheral T-lymphocyte count in pityriasis rosea. (20921775)
1998
26
Human herpesvirus 7 in pityriasis rosea. (9149704)
1997
27
A pityriasis rosea-like eruption secondary to bacillus Calmette-GuAcrin therapy for bladder cancer. (8804852)
1996
28
Recurrent pityriasis rosea. New episodes every year for five years. A case report. (1969211)
1990
29
An epidemiological study of pityriasis rosea in Middle Road Hospital. (2595391)
1989
30
Meyerson's naevi in pityriasis rosea. (2923801)
1989
31
Evolutionary changes of immunohistological characteristics of secondary lesions in pityriasis rosea. (2462853)
1988
32
Pityriasis rosea with erythema multiforme-like lesions. (3611442)
1987
33
Treatment of pityriasis rosea with UV radiation. (6847217)
1983
34
Recent upper respiratory tract infection and pityriasis rosea: a case-control study of 249 matched pairs. (6849825)
1983
35
Pityriasis rosea-like rash from captopril. (7039511)
1982
36
Is pityriasis rosea infectious? (6110883)
1981
37
Pityriasis rosea (Herald spot). (753853)
1977
38
Cytolytic degeneration of keratinocytes adjacent to Langerhans cells in pityriasis rosea (Gibert). (58531)
1976
39
Pityriasis rosea. (5791923)
1969
40
Pityriasis rosea. (5366150)
1969
41
Pityriasis rosea. (4169075)
1968
42
PITYRIASIS ROSEA, WITH SPECIAL EMPHASIS IN CHILDREN. (14045147)
1963
43
Does the tanned skin prevent eruption of pityriasis rosea? (13443506)
1957
44
Pityriasis rosea. (13370205)
1956
45
The nature of pityriasis rosea. [Hebrew text; English summary]. (14860657)
1951
46
Coincidence of pityriasis rosea with pregnancy. (14770492)
1950
47
Pityriasis rosea resembling secondary syphilis. (20983406)
1946
48
Pityriasis Rosea with Unusual Distribution. (19979906)
1917
49
Discussion on Pityriasis Rosea. (19977612)
1914
50
Discussion on Pityriasis Rosea. (19977610)
1914

Variations for Pityriasis Rosea

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Expression for genes affiliated with Pityriasis Rosea

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pityriasis Rosea

Search GEO for disease gene expression data for Pityriasis Rosea.

Pathways for genes affiliated with Pityriasis Rosea

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 61Thomson Reuters, 31KEGG, 58SinoBiological, 55R&D Systems, 54QIAGEN
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Pathways related to Pityriasis Rosea according to GeneCards/GeneDecks:

(show all 34)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IFNA2, HLA-B
2
Show member pathways
TCR signaling in naive CD8+ T cells39
9.5HLA-DRB1, HLA-A
3
Show member pathways
9.0HLA-C, HLA-A, HLA-B
49.0HLA-C, HLA-A, HLA-B
59.0HLA-B, HLA-A, HLA-C
69.0HLA-B, HLA-A, HLA-C
7
Show member pathways
8.9HLA-A, HLA-DQB1, HLA-C, HLA-DRB5
88.8HLA-DRB1, HLA-DRB4, HLA-DRB5, HLA-DRB3
9
Show member pathways
8.7HLA-B, HLA-A, HLA-C, IFNA2
10
Show member pathways
Immune response CD16 signaling in NK cells61
8.7HLA-B, HLA-A, HLA-C, IFNA2
11
Show member pathways
8.4HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
12
Show member pathways
8.4HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
138.4HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
14
Show member pathways
8.4HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
15
Show member pathways
8.4HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
168.4HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
17
Show member pathways
Immune response IL 22 signaling pathway61
G protein signaling N RAS regulation pathway61
8.4HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
18
Show member pathways
8.4HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
19
Show member pathways
8.4HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
20
Show member pathways
8.4HLA-DRB1, HLA-DRB4, HLA-DRB5, HLA-DQB1, HLA-DRB3
21
Show member pathways
8.4HLA-DRB1, HLA-DRB4, HLA-DRB5, HLA-DQB1, HLA-DRB3
228.4HLA-DRB1, HLA-DRB4, HLA-DRB5, HLA-DQB1, HLA-DRB3
23
Show member pathways
8.4HLA-DRB1, HLA-DRB4, HLA-DRB5, HLA-DQB1, HLA-DRB3
24
Show member pathways
Immune response T cell receptor signaling pathway61
Immune response CD28 signaling61
Immune response ICOS pathway in T helper cell61
8.4HLA-DRB1, HLA-DRB4, HLA-DRB5, HLA-DQB1, HLA-DRB3
258.1HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1, IFNA2
266.9HLA-B, HLA-DRB3, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5
276.9HLA-B, HLA-DRB3, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5
28
Show member pathways
6.9HLA-B, HLA-DRB3, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5
296.9HLA-B, HLA-DRB3, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5
30
Show member pathways
6.9HLA-B, HLA-DRB3, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5
316.9HLA-DRB4, HLA-DRB1, HLA-DRB5, HLA-C, HLA-DQB1, HLA-B
32
Show member pathways
6.6HLA-DRB1, IFNA2, HLA-DRB4, HLA-DRB5, HLA-B, HLA-DRB3
33
Show member pathways
6.6HLA-B, HLA-DRB3, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5
34
Show member pathways
6.6HLA-B, HLA-DRB3, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5

Compounds for genes affiliated with Pityriasis Rosea

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 3BitterDB, 25HMDB
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Compounds related to Pityriasis Rosea according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1levamisole46 1210.9HLA-A, IFNA2
2dr-10469.8HLA-DRB1, HLA-A
3busulfan46 52 1211.7HLA-B, IFNA2
4dapsone46 3 52 1212.6IFNA2, HLA-B
5ecori469.6HLA-B, HLA-DQB1
62,5-oligoadenylate469.4IFNA2, HLA-B
7carbamazepine46 52 1211.4HLA-A, HLA-B
8allopurinol46 52 1211.3IFNA2, HLA-A, HLA-B
9ursodeoxycholic acid46 25 1211.3HLA-B, HLA-A, IFNA2
10ribavirin46 52 1211.2IFNA2, HLA-B
11histidine469.1HLA-B, HLA-DQB1, IFNA2
12oligonucleotide468.6HLA-DRB1, HLA-DQB1, HLA-A, HLA-B
13tyrosine468.2IFNA2, HLA-DRB1, HLA-DQB1, HLA-A, HLA-B

GO Terms for genes affiliated with Pityriasis Rosea

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17Gene Ontology
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Cellular components related to Pityriasis Rosea according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1MHC class I protein complexGO:0426129.2HLA-C, HLA-A, HLA-B
2phagocytic vesicle membraneGO:0306709.1HLA-C, HLA-A, HLA-B
3late endosome membraneGO:0319029.0HLA-DRB3, HLA-DRB5, HLA-DRB4, HLA-DRB1
4early endosome membraneGO:0319018.9HLA-C, HLA-A, HLA-B
5external side of plasma membraneGO:0098978.9HLA-DRB3, HLA-DRB5, HLA-DRB4, HLA-DRB1
6MHC class II protein complexGO:0426138.7HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
7clathrin-coated endocytic vesicle membraneGO:0306698.7HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
8transport vesicle membraneGO:0306588.7HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
9trans-Golgi network membraneGO:0325888.7HLA-DRB1, HLA-DRB4, HLA-DRB5, HLA-DQB1, HLA-DRB3
10endocytic vesicle membraneGO:0306668.7HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
11lysosomal membraneGO:0057658.6HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
12membraneGO:0160208.4HLA-DRB1, HLA-DQB1, HLA-DRB3, HLA-B
13cell surfaceGO:0099868.2HLA-B, HLA-A, HLA-C, CX3CL1
14extracellular vesicular exosomeGO:0700627.9HLA-B, HLA-A, HLA-C, HLA-DRB5, HLA-DRB1
15integral component of plasma membraneGO:0058877.8HLA-B, HLA-DRB3, HLA-A, HLA-C, HLA-DRB4, HLA-DRB1
16ER to Golgi transport vesicle membraneGO:0125077.3HLA-DRB1, HLA-B, HLA-DRB3, HLA-A, HLA-DQB1, HLA-C
17integral component of lumenal side of endoplasmic reticulum membraneGO:0715567.3HLA-B, HLA-DRB3, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5
18Golgi membraneGO:0001397.2HLA-B, HLA-DRB3, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5
19plasma membraneGO:0058866.3HLA-B, HLA-DRB3, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5

Biological processes related to Pityriasis Rosea according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independentGO:0024869.3HLA-B, HLA-A, HLA-C
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:0024809.2HLA-C, HLA-A, HLA-B
3regulation of interleukin-10 secretionGO:20011799.1HLA-DRB3, HLA-DRB5, HLA-DRB4, HLA-DRB1
4regulation of interleukin-4 productionGO:0326739.1HLA-DRB3, HLA-DRB5, HLA-DRB4, HLA-DRB1
5positive regulation of T cell mediated cytotoxicityGO:0019169.1HLA-C, HLA-A, HLA-B
6T-helper 1 type immune responseGO:0420889.1HLA-DRB3, HLA-DRB5, HLA-DRB4, HLA-DRB1
7inflammatory response to antigenic stimulusGO:0024379.1HLA-DRB1, HLA-DRB4, HLA-DRB5, HLA-DRB3
8positive regulation of insulin secretion involved in cellular response to glucose stimulusGO:0357749.1HLA-DRB3, HLA-DRB5, HLA-DRB4, HLA-DRB1
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:0024799.1HLA-B, HLA-A, HLA-C
10negative regulation of interferon-gamma productionGO:0326899.1HLA-DRB1, HLA-DRB4, HLA-DRB5, HLA-DRB3
11protein tetramerizationGO:0512629.0HLA-DRB3, HLA-DRB5, HLA-DRB4, HLA-DRB1
12defense responseGO:0069529.0CX3CL1, HLA-B
13antigen processing and presentation of exogenous peptide antigen via MHC class IGO:0425909.0HLA-C, HLA-A, HLA-B
14negative regulation of T cell proliferationGO:0421309.0HLA-DRB3, HLA-DRB5, HLA-DRB4, HLA-DRB1
15regulation of immune responseGO:0507768.9HLA-B, HLA-A, HLA-C
16type I interferon signaling pathwayGO:0603378.9HLA-B, HLA-A, HLA-C, IFNA2
17humoral immune response mediated by circulating immunoglobulinGO:0024558.8HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
18immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023818.8HLA-DRB1, HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4
19antigen processing and presentation of peptide antigen via MHC class IGO:0024748.7HLA-C, HLA-A, HLA-B
20T cell costimulationGO:0312958.7HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
21T cell receptor signaling pathwayGO:0508528.7HLA-DRB1, HLA-DRB4, HLA-DRB5, HLA-DQB1, HLA-DRB3
22antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198868.7HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
23detection of bacteriumGO:0160458.1HLA-A, HLA-DRB5, HLA-DRB4, HLA-DRB1, HLA-DRB3, HLA-B
24interferon-gamma-mediated signaling pathwayGO:0603337.3HLA-B, HLA-DRB3, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5
25immune responseGO:0069556.5CX3CL1, HLA-B, HLA-DRB3, HLA-A, HLA-DQB1, HLA-C
26cytokine-mediated signaling pathwayGO:0192216.1HLA-DRB3, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5, HLA-DRB4

Molecular functions related to Pityriasis Rosea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1TAP bindingGO:0469778.7HLA-C, HLA-A, HLA-B
2MHC class II receptor activityGO:0323958.6HLA-DRB3, HLA-DQB1, HLA-DRB4, HLA-DRB1
3receptor bindingGO:0051028.2CX3CL1, HLA-C, HLA-A, HLA-B
4peptide antigen bindingGO:0426057.4HLA-DRB1, HLA-DRB4, HLA-DRB5, HLA-C, HLA-A, HLA-DRB3

Products for genes affiliated with Pityriasis Rosea

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  • Antibodies
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Sources for Pityriasis Rosea

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet