Pityriasis Rosea malady

Wikipedia: Pityriasis rosea (also known as pityriasis rosea Gibert) is a skin rash. It is benign but may inflict...⁴⁴ more...

MalaCards: Pityriasis Rosea, also known as pityriasis rosea (disorder), is related to birdshot chorioretinopathy and halo nevi. An important gene associated with Pityriasis Rosea is GZMK (granzyme K (granzyme 3; tryptase II)), and among its related pathways are Cell adhesion molecules (CAMs) and Immune response_Antigen presentation by MHC class I. The drugs methdilazine and methdilazine hydrochloride and the compounds ecori and busulfan have been mentioned in the context of this disorder. Affiliated tissues include skin.

Aliases & Descriptions:

pityriasis rosea 6 8 43 pityriasis rosea (disorder) 6

pityriasis circinata 6

Diseases related to pityriasis rosea by text searches and GeneDecks gene sharing:

(show top 50)    (show all 243)

id	Related Disease	Score	Top Affiliating Genes
1	birdshot chorioretinopathy	13.1	HLA-A, HLA-C
2	halo nevi	12.9	HLA-DRB1, HLA-DRB4
3	rheumatoid vasculitis	12.8	HLA-DRB1, CX3CL1
4	primary sclerosing cholangitis	12.7	HLA-A, HLA-C
5	sympathetic ophthalmia	12.7	HLA-C, HLA-DRB1
6	focal epithelial hyperplasia	12.7	IFNA2, HLA-DRB1
7	htlv-1 associated myelopathy	12.6	HLA-A, HLA-B, HLA-C
8	lambert-eaton myasthenic syndrome	12.6	HLA-B, HLA-DQB1, HLA-DRB3
9	spondyloarthropathy	12.6	HLA-A, HLA-B, HLA-C
10	multiple sclerosis	12.6	HLA-DQB1, HLA-DRB1
11	tubulointerstitial nephritis and uveitis	12.6	HLA-DQB1, HLA-DRB1
12	myasthenic syndrome	12.5	HLA-B, HLA-DQB1, HLA-DRB3
13	nephropathia epidemica	12.5	HLA-B, HLA-DRB1
14	human immunodeficiency virus infectious disease	12.5	HLA-A, HLA-B, HLA-C
15	autoimmune thrombocytopenic purpura	12.5	IFNA2, HLA-DRB1
16	dengue shock syndrome	12.5	HLA-A, HLA-DRB1
17	cervical dystonia	12.5	HLA-DQB1, HLA-DRB1
18	common wart	12.5	HLA-DQB1, HLA-DRB1
19	cystic echinococcosis	12.5	HLA-B, HLA-DRB1
20	hypersomnia	12.4	HLA-DQB1, HLA-DRB1
21	psoriatic arthritis	12.4	HLA-C, HLA-DRB1
22	mixed connective tissue disease	12.4	HLA-A, HLA-DRB1, HLA-DRB4
23	leprosy	12.4	HLA-DQB1, HLA-DRB1
24	acute disseminated encephalomyelitis	12.3	HLA-DQB1, HLA-DRB1
25	ocular cicatricial pemphigoid	12.3	HLA-DQB1, HLA-DRB1
26	acute chest syndrome	12.3	HLA-DQB1, HLA-DRB1
27	postherpetic neuralgia	12.3	HLA-A, HLA-B, HLA-DRB1
28	pars planitis	12.2	HLA-A, HLA-B, HLA-DRB1
29	histoplasmosis	12.2	HLA-A, HLA-B, HLA-DRB1
30	guillain-barre syndrome	12.2	HLA-DQB1, HLA-DRB1, HLA-DRB4
31	aphthous stomatitis	12.2	HLA-A, HLA-B, HLA-DRB1
32	porphyria cutanea tarda	12.2	HLA-A, HLA-B, HLA-DRB1
33	takayasu's arteritis	12.2	HLA-A, HLA-B, HLA-DRB1
34	deep vein thrombosis	12.2	HLA-A, HLA-B, HLA-DRB1
35	hepatitis	12.2	IFNA2, HLA-A, HLA-DRB1
36	visceral leishmaniasis	12.1	HLA-DQB1, HLA-DRB1, PKD2L1
37	variegate porphyria	12.1	HLA-A, HLA-B, HLA-DRB1
38	peyronies disease	12.1	IFNA2, HLA-A, HLA-B, HLA-C
39	antiphospholipid syndrome	12.1	HLA-DQB1, HLA-DRB1, HLA-DRB4
40	follicular lymphoma	12.1	IFNA2, HLA-C, HLA-DQB1
41	autoimmune hepatitis	12.1	HLA-A, HLA-DQB1, HLA-DRB1
42	acne	12.1	IFNA2, HLA-A, HLA-B, HLA-C
43	aggressive periodontitis	12.1	HLA-A, HLA-B, HLA-DRB1
44	duchenne muscular dystrophy	12.1	HLA-A, HLA-B, HLA-DRB1
45	hepatitis c	12.1	IFNA2, HLA-A, HLA-DRB1
46	whipple disease	12.1	HLA-B, HLA-DQB1, HLA-DRB1
47	recurrent respiratory papillomatosis	12.1	IFNA2, HLA-DQB1, HLA-DRB1
48	trachoma	12.1	HLA-B, HLA-DQB1, HLA-DRB1
49	hemochromatosis	12.0	HLA-A, HLA-B, HLA-DRB1
50	celiac disease	12.0	HLA-DQB1, HLA-DRB1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 methdilazine, methdilazine hydrochloride

MalaCards organs/tissues related to pityriasis rosea:

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Articles related to pityriasis rosea:

id	Title	Authors	Year	Affiliating Genes
1	The CX3C-chemokine fractalkine (CX3CL1) is detectable in serum of patients affected by active pityriasis rosea. (17062081)	Gangemi S.... Rebora A.	2006	CX3CL1
2	Correlation between HLA and pityriasis rosea susceptibility in Brazilian blacks. (16405603)	Miranda S.M.... Filgueira A.L.	2006	HLA-A, HLA-DQB1, HLA-DRB1
3	Pityriasis rosea in a patient with BehAset's disease treated with interferon alpha 2A. (10343467)	Durusoy C.... Yilmaz E.	1999	IFNA2

Genes related to pityriasis rosea according to GeneCards:

(show all 12)

id	Symbol	Description	Score	GeneCards Section Context
1	GZMK	granzyme K (granzyme 3; tryptase II)	11.0
2	CX3CL1	chemokine (C-X3-C motif) ligand 1	11.0	Publications
3	HLA-DRB4	major histocompatibility complex, class II, DR beta 4	11.0	Publications
4	HLA-DRB3	major histocompatibility complex, class II, DR beta 3	11.0	Publications
5	PKD2L1	polycystic kidney disease 2-like 1	11.0
6	HLA-DRB5	major histocompatibility complex, class II, DR beta 5	11.0	Publications
7	HLA-C	major histocompatibility complex, class I, C	11.0	Publications
8	IFNA2	interferon, alpha 2	11.0	Publications
9	HLA-A	major histocompatibility complex, class I, A	11.0	Publications
10	HLA-B	major histocompatibility complex, class I, B	11.0	Publications
11	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	11.0	Publications
12	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	11.0	Publications

Pathways related to pityriasis rosea according to GeneDecks:

(show all 46)

id	Pathway	Score	Top Affiliating Genes
1	Cell adhesion molecules (CAMs)20	10.5	HLA-DRB5
2	Immune response_Antigen presentation by MHC class I41	8.9	HLA-A, HLA-B, HLA-C
3	Hematopoietic cell lineage20	8.7	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
4	Immune response Antigen presentation by MHC class I10	8.6	HLA-A, HLA-B, HLA-C
5	MHC class II antigen presentation38	8.5	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
6	Asthma20	8.5	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
7	Immune response Antigen presentation by MHC class II10	8.5	HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5
8	Immune response_Antigen presentation by MHC class II41	8.5	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
9	THC Differentiation Pathway36	8.5	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
10	Calcium Mediated T-Cell Apoptosis36	8.5	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
11	Intestinal immune network for IgA production20	8.5	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
12	G-protein signaling N-RAS regulation pathway10	8.5	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
13	Staphylococcus aureus infection20	8.5	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
14	G-protein signaling_N-RAS regulation pathway41	8.5	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
15	Immune response IL-22 signaling pathway10	8.5	HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DQB1
16	IL-4 Pathway36	8.5	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
17	Immune response_IL-22 signaling pathway41	8.5	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
18	CTLA4 Signaling36	8.5	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
19	Leishmaniasis20	8.5	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
20	Immune response T cell receptor signaling pathway10	8.5	HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5
21	ICos-ICosL Pathway in T-Helper Cell36	8.5	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
22	Immune response_T cell receptor signaling pathway41	8.4	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
23	Rheumatoid arthritis20	8.4	HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5
24	Immune response ICOS pathway in T-helper cell10	8.4	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
25	Immune response_ICOS pathway in T-helper cell41	8.4	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
26	Immune response NFAT in immune response10	8.4	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
27	CD28 Signaling in T-Helper Cell36	8.4	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
28	Immune response_NFAT in immune response41	8.4	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
29	Natural killer cell mediated cytotoxicity20	8.4	HLA-C, HLA-B, HLA-A, IFNA2
30	Graft-versus-host disease20	8.4	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-C, HLA-B, HLA-A
31	PKC-Theta Pathway36	8.4	HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5
32	ITK and TCR Signaling36	8.3	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
33	Toxoplasmosis20	8.3	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
34	Systemic lupus erythematosus20	8.3	HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5
35	TCR Signaling36	8.2	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
36	NFAT in Immune Response36	8.1	HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5
37	Influenza A20	8.0	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, IFNA2
38	Tuberculosis20	8.0	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, IFNA2
39	Allograft rejection20	7.0	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-C
40	Type I diabetes mellitus20	7.0	HLA-A, HLA-B, HLA-C, HLA-DQB1, HLA-DRB5, HLA-DRB4
41	CTL Mediated Apoptosis36	7.0	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-C
42	Antigen processing and presentation20	7.0	HLA-C, HLA-B, HLA-A, HLA-DQB1, HLA-DRB1, HLA-DRB3
43	Viral myocarditis20	7.0	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-C
44	Phagosome20	7.0	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-C
45	CDC42 Pathway36	7.0	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-C
46	Autoimmune thyroid disease20	6.6	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-C

Compounds related to pityriasis rosea according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	ecori32	9.3	HLA-B, HLA-DQB1
2	busulfan32 9 9	11.3	HLA-B, IFNA2
3	dr-1032	9.2	HLA-A, HLA-DRB1
4	levamisole32 9 9	11.2	IFNA2, HLA-A
5	ursodeoxycholic acid32 9 18 9	11.9	IFNA2, HLA-A, HLA-B

Cellular components related to pityriasis rosea according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	Golgi membrane	GO:000139	9.2	HLA-DQB1, HLA-DRB3, HLA-DRB4, HLA-DRB5
2	MHC class I protein complex	GO:042612	9.0	HLA-C, HLA-B, HLA-A
3	phagocytic vesicle membrane	GO:030670	8.9	HLA-A, HLA-B, HLA-C
4	early endosome membrane	GO:031901	8.9	HLA-A, HLA-B, HLA-C
5	late endosome membrane	GO:031902	8.8	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
6	external side of plasma membrane	GO:009897	8.6	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
7	MHC class II protein complex	GO:042613	8.4	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
8	clathrin-coated endocytic vesicle membrane	GO:030669	8.4	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
9	trans-Golgi network membrane	GO:032588	8.4	HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5
10	transport vesicle membrane	GO:030658	8.4	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
11	endocytic vesicle membrane	GO:030666	8.3	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
12	lysosomal membrane	GO:005765	8.3	HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5
13	integral to plasma membrane	GO:005887	7.2	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-C, HLA-B, HLA-A
14	ER to Golgi transport vesicle membrane	GO:012507	6.9	HLA-A, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
15	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	6.9	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-C
16	plasma membrane	GO:005886	6.1	CX3CL1, PKD2L1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1

Biological processes related to pityriasis rosea according to GeneDecks:

(show all 23)

id	Name	GO ID	Score	Top Affiliating Genes
1	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	GO:002480	9.0	HLA-A, HLA-B, HLA-C
2	regulation of interleukin-10 secretion	GO:2001179	9.0	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
3	regulation of interleukin-4 production	GO:032673	9.0	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
4	inflammatory response to antigenic stimulus	GO:002437	9.0	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
5	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO:035774	8.9	HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5
6	T-helper 1 type immune response	GO:042088	8.9	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
7	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	GO:002479	8.9	HLA-A, HLA-B, HLA-C
8	regulation of immune response	GO:050776	8.9	HLA-A, HLA-B, HLA-C
9	negative regulation of interferon-gamma production	GO:032689	8.9	HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5
10	protein tetramerization	GO:051262	8.9	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
11	antigen processing and presentation of exogenous peptide antigen via MHC class I	GO:042590	8.8	HLA-C, HLA-B, HLA-A
12	negative regulation of T cell proliferation	GO:042130	8.8	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
13	antigen processing and presentation of peptide antigen via MHC class I	GO:002474	8.6	HLA-A, HLA-B, HLA-C
14	type I interferon-mediated signaling pathway	GO:060337	8.5	HLA-C, HLA-B, HLA-A, IFNA2
15	immunoglobulin production involved in immunoglobulin mediated immune response	GO:002381	8.5	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
16	humoral immune response mediated by circulating immunoglobulin	GO:002455	8.5	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
17	T cell costimulation	GO:031295	8.4	HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5
18	T cell receptor signaling pathway	GO:050852	8.4	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
19	antigen processing and presentation of exogenous peptide antigen via MHC class II	GO:019886	8.3	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
20	detection of bacterium	GO:016045	7.9	HLA-A, HLA-B, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5
21	interferon-gamma-mediated signaling pathway	GO:060333	6.9	HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DQB1, HLA-C
22	immune response	GO:006955	6.6	CX3CL1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
23	cytokine-mediated signaling pathway	GO:019221	6.2	IFNA2, HLA-A, HLA-B, HLA-C, HLA-DQB1, HLA-DRB1

Molecular functions related to pityriasis rosea according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class I receptor activity	GO:032393	8.9	HLA-A, HLA-B, HLA-C
2	MHC class II receptor activity	GO:032395	8.4	HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-DRB4
3	peptide antigen binding	GO:042605	8.4	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1