MCID: PTY001
MIFTS: 45

Pityriasis Rosea malady

Skin diseases category

Summaries for Pityriasis Rosea

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63Wikipedia, 32MalaCards
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Wikipedia:63 Pityriasis rosea (also known as pityriasis rosea Gibert) is a skin rash. It is benign but may inflict... more...

MalaCards: Pityriasis Rosea, also known as pityriasis circinata, is related to psoriasis and lichen planus. An important gene associated with Pityriasis Rosea is HLA-DRB4 (major histocompatibility complex, class II, DR beta 4), and among its related pathways are Classical antibody-mediated complement activation and COPII (Coat Protein 2) Mediated Vesicle Transport. The drugs methdilazine and methdilazine hydrochloride and the compounds dr-10 and ecori have been mentioned in the context of this disorder. Affiliated tissues include skin, bone marrow and bone.

Aliases & Classifications for Pityriasis Rosea

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

pityriasis rosea 8 60
pityriasis circinata 8


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Disease Ontology8 DOID:8892
NCIt39 C26855
ICD9CM27 696.3
SNOMED-CT56 77252004, 156373006
MeSH34 D017515
ICD1025 L42

Related Diseases for Pityriasis Rosea

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17GeneCards, 18GeneDecks
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Diseases related to Pityriasis Rosea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1psoriasis30.7HLA-C, HLA-B, HLA-DRB1, HLA-A, CX3CL1
2lichen planus30.7IFNA2
3hepatitis30.5IFNA2, HLA-DRB1, HLA-A
4influenza30.4HLA-A, HLA-B
5hepatitis b30.4HLA-DRB1, HLA-DQB1, IFNA2
6stomatitis30.2IFNA2
7aphthous stomatitis30.2HLA-B
8skin disease30.2HLA-DRB1
9multiple sclerosis30.2HLA-DRB1, HLA-DQB1
10hepatitis c30.2IFNA2, HLA-DRB1, HLA-A
11arthritis30.2HLA-C, HLA-B, HLA-DRB1, HLA-A
12rheumatoid arthritis30.2HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1, HLA-A, CX3CL1
13dermatitis10.5
14syphilis10.4
15erythema multiforme10.3
16pityriasis versicolor10.3
17secondary syphilis10.3
18herpes simplex10.3
19pityriasis rotunda10.2
20bruxism10.2
21bell's palsy10.2
22atopic dermatitis10.2
23parapsoriasis10.2
24polyarteritis nodosa10.2
25herpes zoster10.2
26epidermolysis bullosa dystrophica10.2
27hepatitis a10.2
28allergic contact dermatitis10.2
29contact dermatitis10.2
30cutaneous mastocytosis10.2
31dermatitis herpetiformis10.2
32epidermolysis bullosa10.2
33exanthem10.2
34histiocytosis10.2
35keratosis10.2
36lichen disease10.2
37nephrotic syndrome10.2
38pneumonia10.2
39smallpox10.2
40dementia10.0CX3CL1
41peyronies disease10.0IFNA2
42visceral leishmaniasis10.0PKD2L1
43vitiligo10.0HLA-B
44measles10.0HLA-A
45cryoglobulinemic vasculitis10.0IFNA2
46myositis10.0HLA-B
47focal epithelial hyperplasia10.0IFNA2
48endometriosis10.0HLA-A
49polymyositis10.0HLA-B
50splenomegaly10.0IFNA2

Graphical network of the top 20 diseases related to Pityriasis Rosea:



Diseases related to pityriasis rosea

Clinical Features for Pityriasis Rosea

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Drugs & Therapeutics for Pityriasis Rosea

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pityriasis Rosea

Drug clinical trials:

Search ClinicalTrials for Pityriasis Rosea

Search NIH Clinical Center for Pityriasis Rosea

Search CenterWatch for Pityriasis Rosea

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Pityriasis Rosea

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Anatomical Context for Pityriasis Rosea

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32MalaCards
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MalaCards organs/tissues related to Pityriasis Rosea:

32
Skin, Bone marrow, Bone, Testes, Myeloid, T cells, Tongue

Animal Models for Pityriasis Rosea or affiliated genes

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Publications for Pityriasis Rosea

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50PubMed
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Articles related to Pityriasis Rosea:

(show top 50)    (show all 342)
idTitleAuthorsYear
1
Palmar herald patch in pityriasis rosea. (22881477)
2012
2
Accuracy of dermoscopic criteria for the diagnosis of psoriasis, dermatitis, lichen planus and pityriasis rosea. (22296226)
2012
3
Pityriasis rosea-like Drug Eruption Induced by Imatinib Mesylate (Gleeveca8c). (22346278)
2011
4
Segmental lesions in pityriasis rosea: a rare presentation. (22256628)
2011
5
Pityriasis rosea in a woman and her husband - case report and review of the literature. (21399750)
2010
6
Pityriasis rosea and herpesviruses: facts and controversies. (20797508)
2010
7
Giant pityriasis rosea. (20606895)
2010
8
Atypical Pityriasis rosea in a black child: a case report. (20181179)
2009
9
Detection of human herpesvirus 8 in the skin of patients with pityriasis rosea. (19997691)
2009
10
Anxiety and depression in patients with pityriasis rosea compared to patients with tinea versicolor. (19051783)
2008
11
Clinicoepidemiological study of pityriasis rosea. (19171994)
2008
12
A teenage girl with rash. Pityriasis rosea. (18972848)
2008
13
Purpuric pityriasis rosea-like eruption: a cutaneous marker of acute myeloid leukaemia. (17567315)
2007
14
Pityriasis rosea in pregnancy. (17604600)
2007
15
Palmoplantar pityriasis rosea: two case reports. (17309476)
2007
16
The natural history of pityriasis rosea in black American children: how correct is the "classic" description? (17485628)
2007
17
Macular eruption. Pityriasis rosea. (17044638)
2006
18
Additional evidence that pityriasis rosea is associated with reactivation of human herpesvirus-6 and -7. (15955099)
2005
19
Pityriasis rosea--an update. (16394453)
2005
20
Pityriasis rosea-like eruption during treatment with imatinib mesylate: description of 3 cases. (16227099)
2005
21
Pityriasis rosea unilateralis. (17642826)
2003
22
Diagnostic criteria for pityriasis rosea: a prospective case control study for assessment of validity. (12602987)
2003
23
Papular pityriasis rosea. (12184673)
2002
24
Detection of human herpesvirus 7 in pityriasis rosea by nested PCR. (12358824)
2002
25
Collarette scaling in pityriasis rosea demonstrated by digital epiluminescence dermatoscopy. (11903165)
2001
26
Pityriasis rosea: A histopathologic study. (20877089)
2000
27
Pityriasis rosea in a patient with BehAset's disease treated with interferon alpha 2A. (10343467)
1999
28
Pityriasis rosea. (10429145)
1999
29
'Hanging curtain' sign in pityriasis rosea. (7599393)
1995
30
Purpuric pityriasis rosea. (8496449)
1993
31
Tongue and cheek: oral lesions in pityriasis rosea. (1424793)
1992
32
Pityriasis rosea. (1749697)
1991
33
Patient education. Pityriasis rosea. (2363663)
1990
34
Pityriasis rosea-like eruption associated with BCG vaccination. (2807857)
1989
35
Oral lesions associated with pityriasis rosea. (3707161)
1986
36
Atypical pityriasis rosea. (4092804)
1985
37
Is pityriasis rosea dying? (6724773)
1984
38
Pityriasis rosea-like rash from captopril. (7039511)
1982
39
Purpuric pityriasis rosea. (7351279)
1980
40
Focal acantholytic dyskeratosis in pityriasis rosea. (434880)
1979
41
Dapsone treatment in a case of vesicular pityriasis rosea. (4105359)
1971
42
Pityriasis rosea, aphthous stomatitis, and bruxism--a possible psychosomatic aetiology. (5289526)
1971
43
Oral lesions in pityriasis rosea. (5695010)
1968
44
Pityriasis Rosea in a Herd of Swine. (17421250)
1960
45
Pityriasis-rosea-like eruption following smallpox vaccination. (13434484)
1957
46
Treatment of pityriasis rosea with nonspecific substances. (18110550)
1948
47
Discussion on Pityriasis Rosea. (19977612)
1914
48
Discussion on Pityriasis Rosea. (19977609)
1914
49
Discussion on Pityriasis Rosea. (19977604)
1914
50
Discussion on Pityriasis Rosea. (19977606)
1914

Genetic Variations for Pityriasis Rosea

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Expression for genes affiliated with Pityriasis Rosea

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pityriasis Rosea

Search GEO for disease gene expression data for Pityriasis Rosea.

Pathways for genes affiliated with Pityriasis Rosea

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53Reactome, 29KEGG, 12EMD Millipore, 55SinoBiological, 51QIAGEN
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Pathways related to Pityriasis Rosea according to GeneCards/GeneDecks:

(show all 37)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.3HLA-A, HLA-B, HLA-C
2
Hide members
9.3HLA-A, HLA-B, HLA-C
39.3HLA-A, HLA-B, HLA-C
49.3HLA-A, HLA-B, HLA-C
59.3HLA-C, HLA-B, HLA-A
69.3HLA-C, HLA-B, HLA-A
7
Hide members
9.2HLA-C, HLA-DQB1, HLA-DRB5, HLA-A
8
Immune response IFN alpha/beta signaling pathway
Hide members
9.0IFNA2, HLA-C, HLA-B, HLA-A
9
Hide members
9.0IFNA2, HLA-C, HLA-B, HLA-A
108.7HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5
118.4HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DQB1
12
Hide members
8.4HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DQB1
138.4HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DQB1
14
Hide members
8.4HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DQB1
15
Immune response NFAT in immune response
Hide members
8.4HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DQB1
16
Hide members
8.4HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
17
Hide members
8.4HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
18
Hide members
8.4HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
198.4HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
20
Hide members
8.4HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
21
Hide members
8.4HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
228.4HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
23
Immune response Antigen presentation by MHC class II
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8.4HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
24
Hide members
8.4HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
25
Hide members
8.4HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
26
Immune response ICOS pathway in T-helper cell
Hide members
8.4HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
278.4HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
288.1IFNA2, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
297.2HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-B, HLA-DQB1
307.2HLA-C, HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB4, HLA-DRB3
317.2HLA-C, HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB4, HLA-DRB3
32
Hide members
7.2HLA-C, HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB4, HLA-DRB3
337.2HLA-C, HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB4, HLA-DRB3
34
Hide members
6.9IFNA2, HLA-C, HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB4
35
Hide members
6.9IFNA2, HLA-C, HLA-A, HLA-DRB1, HLA-DRB3, HLA-DRB4
36
Hide members
6.9HLA-A, IFNA2, HLA-C, HLA-DQB1, HLA-B, HLA-DRB5
37
Hide members
6.9IFNA2, HLA-C, HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB4

Compounds for genes affiliated with Pityriasis Rosea

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44Novoseek, 11DrugBank, 24HMDB
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Compounds related to Pityriasis Rosea according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1dr-10449.8HLA-A, HLA-DRB1
2ecori449.7HLA-B, HLA-DQB1
3busulfan44 1110.6IFNA2, HLA-B
4levamisole44 1110.5HLA-A, IFNA2
5ursodeoxycholic acid44 11 2411.4HLA-A, HLA-B, IFNA2

GO Terms for genes affiliated with Pityriasis Rosea

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16Gene Ontology
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Cellular components related to Pityriasis Rosea according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1MHC class I protein complexGO:0426129.5HLA-A, HLA-B, HLA-C
2early endosome membraneGO:0319019.3HLA-A, HLA-B, HLA-C
3phagocytic vesicle membraneGO:0306709.2HLA-C, HLA-B, HLA-A
4late endosome membraneGO:0319028.8HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
5external side of plasma membraneGO:0098978.7HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
6MHC class II protein complexGO:0426138.7HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
7clathrin-coated endocytic vesicle membraneGO:0306698.7HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
8transport vesicle membraneGO:0306588.6HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
9trans-Golgi network membraneGO:0325888.6HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
10endocytic vesicle membraneGO:0306668.6HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
11lysosomal membraneGO:0057658.5HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
12ER to Golgi transport vesicle membraneGO:0125077.5HLA-A, HLA-C, HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB4
13integral to lumenal side of endoplasmic reticulum membraneGO:0715567.5HLA-C, HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB4, HLA-DRB3
14integral to plasma membraneGO:0058877.5HLA-C, HLA-B, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-A
15Golgi membraneGO:0001397.5HLA-C, HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB4, HLA-DRB3
16plasma membraneGO:0058866.2HLA-C, HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB4, HLA-DRB3

Biological processes related to Pityriasis Rosea according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:0024809.4HLA-C, HLA-B, HLA-A
2positive regulation of T cell mediated cytotoxicityGO:0019169.4HLA-C, HLA-B, HLA-A
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:0024799.3HLA-A, HLA-B, HLA-C
4antigen processing and presentation of peptide antigen via MHC class IGO:0024749.3HLA-A, HLA-B, HLA-C
5antigen processing and presentation of exogenous peptide antigen via MHC class IGO:0425909.2HLA-C, HLA-B, HLA-A
6type I interferon-mediated signaling pathwayGO:0603379.1HLA-A, HLA-B, HLA-C, IFNA2
7regulation of interleukin-10 secretionGO:20011799.0HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
8regulation of interleukin-4 productionGO:0326739.0HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
9regulation of immune responseGO:0507769.0HLA-A, HLA-B, HLA-C
10T-helper 1 type immune responseGO:0420889.0HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
11inflammatory response to antigenic stimulusGO:0024379.0HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
12positive regulation of insulin secretion involved in cellular response to glucose stimulusGO:0357749.0HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5
13negative regulation of interferon-gamma productionGO:0326898.9HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5
14negative regulation of T cell proliferationGO:0421308.9HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
15protein tetramerizationGO:0512628.9HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5
16immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023818.7HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
17humoral immune response mediated by circulating immunoglobulinGO:0024558.7HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
18T cell costimulationGO:0312958.7HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
19T cell receptor signaling pathwayGO:0508528.6HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
20antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198868.6HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
21detection of bacteriumGO:0160458.2HLA-A, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-B
22interferon-gamma-mediated signaling pathwayGO:0603337.6HLA-DRB5, HLA-B, HLA-DQB1, HLA-C, HLA-DRB4, HLA-DRB3
23immune responseGO:0069557.0HLA-C, HLA-DQB1, HLA-B, HLA-DRB5, HLA-DRB4, HLA-DRB3
24cytokine-mediated signaling pathwayGO:0192216.7CX3CL1, HLA-A, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5

Molecular functions related to Pityriasis Rosea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051028.8CX3CL1, HLA-A, HLA-B, HLA-C
2MHC class II receptor activityGO:0323958.4HLA-DQB1, HLA-DRB4, HLA-DRB3, HLA-DRB1
3peptide antigen bindingGO:0426057.4HLA-A, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-B

Products for genes affiliated with Pityriasis Rosea

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Sources for Pityriasis Rosea

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet