MCID: PTY001
MIFTS: 50

Pityriasis Rosea malady

Skin diseases category
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Summaries for Pityriasis Rosea

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Wikipedia:65 Pityriasis rosea (also known as pityriasis rosea Gibert) is a skin rash. It is benign but may inflict... more...

MalaCards based summary: Pityriasis Rosea, also known as pityriasis circinata, is related to polyarteritis nodosa and hepatitis. An important gene associated with Pityriasis Rosea is HLA-DRB4 (major histocompatibility complex, class II, DR beta 4), and among its related pathways are Type II interferon signaling (IFNG) and TCR signaling in naive CD4+ T cells. The drugs methdilazine and methdilazine hydrochloride and the compounds levamisole and dr-10 have been mentioned in the context of this disorder. Affiliated tissues include skin, bone marrow and bone.

Aliases & Classifications for Pityriasis Rosea

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Pityriasis Rosea, Aliases & Descriptions:

Name: Pityriasis Rosea 8 62
 
Pityriasis Circinata 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


External Ids:

Disease Ontology8 DOID:8892
NCIt39 C26855
MeSH34 D017515
SNOMED-CT57 156373006, 77252004
ICD9CM27 696.3
ICD1025 L42

Related Diseases for Pityriasis Rosea

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Diseases related to Pityriasis Rosea via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 92)
idRelated DiseaseScoreTop Affiliating Genes
1polyarteritis nodosa31.0IFNA2
2hepatitis30.6IFNA2, HLA-A, HLA-B
3hepatitis b30.4IFNA2, HLA-DRB1, HLA-DQB1
4psoriasis30.1HLA-A, HLA-DRB1, HLA-C, CX3CL1, HLA-B
5hepatitis c30.1HLA-DRB1, HLA-A, IFNA2
6arthritis29.7HLA-DRB1, HLA-B, HLA-A, HLA-C
7rheumatoid arthritis29.4HLA-DRB5, HLA-A, HLA-DQB1, HLA-DRB4, HLA-DRB1, CX3CL1
8multiple sclerosis29.2HLA-A, HLA-B, HLA-DRB1, HLA-DQB1, HLA-C, HLA-DRB5
9dermatitis10.6
10lichen planus10.5
11blindness10.5
12focal epithelial hyperplasia10.5IFNA2
13influenza10.4
14syphilis10.4
15pityriasis rotunda10.4
16erythema multiforme10.4
17herpes zoster10.4
18secondary syphilis10.4
19exanthem10.4
20herpes simplex10.4
21narcolepsy10.2HLA-DRB1
22epidermolysis bullosa dystrophica10.2
23skin disease10.2
24bruxism10.2
25aphthous stomatitis10.2
26yellow fever10.2
27bell's palsy10.2
28parapsoriasis10.2
29atopic dermatitis10.2
30allergic contact dermatitis10.2
31contact dermatitis10.2
32dermatitis herpetiformis10.2
33epidermolysis bullosa10.2
34histiocytosis10.2
35keratosis10.2
36nephrotic syndrome10.2
37pneumonia10.2
38smallpox10.2
39stomatitis10.2
40gianotti crosti syndrome10.2
41guttate psoriasis10.2
42pityriasis lichenoides10.2
43pityriasis lichenoides et varioliformis acuta10.2
44hepatitis c virus10.2
45indeterminate cell histiocytosis10.2
46autoimmune thyroiditis10.2HLA-DRB4, HLA-B
47human immunodeficiency virus infectious disease10.2HLA-A, HLA-C
48primary sclerosing cholangitis10.2HLA-A, HLA-C
49myasthenia gravis10.1HLA-DQB1, HLA-B
50thyroiditis10.1HLA-C, HLA-DRB1

Graphical network of the top 20 diseases related to Pityriasis Rosea:



Diseases related to pityriasis rosea

Symptoms for Pityriasis Rosea

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Drugs & Therapeutics for Pityriasis Rosea

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Drug clinical trials:

Search ClinicalTrials for Pityriasis Rosea

Search NIH Clinical Center for Pityriasis Rosea

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Pityriasis Rosea

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Anatomical Context for Pityriasis Rosea

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MalaCards organs/tissues related to Pityriasis Rosea:

32
Skin, Bone marrow, Bone, Testes, Myeloid, T cells, Tongue

Animal Models for Pityriasis Rosea or affiliated genes

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Publications for Pityriasis Rosea

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Articles related to Pityriasis Rosea:

(show top 50)    (show all 361)
idTitleAuthorsYear
1
Multiple recurrences in pityriasis rosea - a case report with review of the literature. (24891682)
2014
2
The prevalence of herpes zoster and pityriasis rosea in patients with psoriasis: a preliminary study. (25353629)
2014
3
Polymorphic pityriasis rosea precipitating psoriasis. (23437430)
2013
4
Palmar herald patch in pityriasis rosea. (22881477)
2012
5
Low dose of acyclovir may be an effective treatment against pityriasis rosea: a random investigator-blind clinical trial on 64 patients. (20477925)
2011
6
Pityriasis rosea-like Drug Eruption Induced by Imatinib Mesylate (Gleeveca8c). (22346278)
2011
7
The pityriasis rosea calendar: a 7 year review of seasonal variation, age and sex distribution. (20450028)
2010
8
Pityriasis rosea in a woman and her husband - case report and review of the literature. (21399750)
2010
9
Childhood pityriasis rosea. (20199459)
2009
10
Atypical Pityriasis rosea in a black child: a case report. (20181179)
2009
11
Pregnancy outcome in patients with pityriasis rosea. (18489054)
2008
12
Pityriasis rosea. (18297832)
2008
13
Study of role of streptococcal throat infection in pityriasis rosea. (19882027)
2008
14
Pityriasis rosea occurring during acyclovir therapy. (17558061)
2007
15
Purpuric pityriasis rosea-like eruption: a cutaneous marker of acute myeloid leukaemia. (17567315)
2007
16
Pityriasis rosea. (16948385)
2006
17
Macular eruption. Pityriasis rosea. (17044638)
2006
18
The CX3C-chemokine fractalkine (CX3CL1) is detectable in serum of patients affected by active pityriasis rosea. (17062081)
2006
19
Diseases of the epidermis: pityriasis rosea, lichen planus, keratosis pilaris. (16463931)
2005
20
Is human herpesvirus 7 the causative agent of pityriasis rosea?--A critical review. (15569005)
2004
21
Avidity of antibodies to human herpesvirus 7 suggests primary infection in young adults with pityriasis rosea. (15482314)
2004
22
Pityriasis rosea unilateralis. (17642826)
2003
23
Rash orientation in pityriasis rosea: a qualitative study. (11978566)
2002
24
Human herpes virus-like particles in pityriasis rosea lesions: an electron microscopy study. (12135467)
2002
25
Pityriasis rosea associated with herpesvirus 7 DNA. (11204526)
2000
26
Peripheral T-lymphocyte count in pityriasis rosea. (20921775)
1998
27
Human herpesvirus 7 in pityriasis rosea. (9149704)
1997
28
A pityriasis rosea-like eruption secondary to bacillus Calmette-GuAcrin therapy for bladder cancer. (8804852)
1996
29
Recurrent pityriasis rosea. New episodes every year for five years. A case report. (1969211)
1990
30
An epidemiological study of pityriasis rosea in Middle Road Hospital. (2595391)
1989
31
Meyerson's naevi in pityriasis rosea. (2923801)
1989
32
Evolutionary changes of immunohistological characteristics of secondary lesions in pityriasis rosea. (2462853)
1988
33
Pityriasis rosea with erythema multiforme-like lesions. (3611442)
1987
34
Treatment of pityriasis rosea with UV radiation. (6847217)
1983
35
Recent upper respiratory tract infection and pityriasis rosea: a case-control study of 249 matched pairs. (6849825)
1983
36
Pityriasis rosea-like rash from captopril. (7039511)
1982
37
Is pityriasis rosea infectious? (6110883)
1981
38
Pityriasis rosea (Herald spot). (753853)
1977
39
Cytolytic degeneration of keratinocytes adjacent to Langerhans cells in pityriasis rosea (Gibert). (58531)
1976
40
Pityriasis rosea. (5791923)
1969
41
Pityriasis rosea. (5366150)
1969
42
Pityriasis rosea. (4169075)
1968
43
PITYRIASIS ROSEA, WITH SPECIAL EMPHASIS IN CHILDREN. (14045147)
1963
44
Does the tanned skin prevent eruption of pityriasis rosea? (13443506)
1957
45
Pityriasis rosea. (13370205)
1956
46
The nature of pityriasis rosea. [Hebrew text; English summary]. (14860657)
1951
47
Coincidence of pityriasis rosea with pregnancy. (14770492)
1950
48
Pityriasis Rosea with Unusual Distribution. (19979906)
1917
49
Discussion on Pityriasis Rosea. (19977612)
1914
50
Discussion on Pityriasis Rosea. (19977610)
1914

Variations for Pityriasis Rosea

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Expression for genes affiliated with Pityriasis Rosea

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Expression patterns in normal tissues for genes affiliated with Pityriasis Rosea

Search GEO for disease gene expression data for Pityriasis Rosea.

Pathways for genes affiliated with Pityriasis Rosea

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Pathways related to Pityriasis Rosea according to GeneCards/GeneDecks:

(show all 34)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IFNA2, HLA-B
2
Show member pathways
TCR signaling in naive CD8+ T cells37
9.5HLA-DRB1, HLA-A
3
Show member pathways
9.0HLA-C, HLA-A, HLA-B
49.0HLA-C, HLA-A, HLA-B
59.0HLA-B, HLA-A, HLA-C
69.0HLA-B, HLA-A, HLA-C
7
Show member pathways
8.9HLA-A, HLA-DQB1, HLA-C, HLA-DRB5
88.8HLA-DRB1, HLA-DRB4, HLA-DRB5, HLA-DRB3
9
Show member pathways
8.7HLA-B, HLA-A, HLA-C, IFNA2
10
Show member pathways
Immune response CD16 signaling in NK cells60
8.7HLA-B, HLA-A, HLA-C, IFNA2
11
Show member pathways
8.4HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
12
Show member pathways
8.4HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
138.4HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
14
Show member pathways
8.4HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
15
Show member pathways
8.4HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
168.4HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
17
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
8.4HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
18
Show member pathways
8.4HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
19
Show member pathways
8.4HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
20
Show member pathways
8.4HLA-DRB1, HLA-DRB4, HLA-DRB5, HLA-DQB1, HLA-DRB3
21
Show member pathways
8.4HLA-DRB1, HLA-DRB4, HLA-DRB5, HLA-DQB1, HLA-DRB3
228.4HLA-DRB1, HLA-DRB4, HLA-DRB5, HLA-DQB1, HLA-DRB3
23
Show member pathways
8.4HLA-DRB1, HLA-DRB4, HLA-DRB5, HLA-DQB1, HLA-DRB3
24
Show member pathways
Immune response T cell receptor signaling pathway60
Immune response CD28 signaling60
Immune response ICOS pathway in T helper cell60
8.4HLA-DRB1, HLA-DRB4, HLA-DRB5, HLA-DQB1, HLA-DRB3
258.1HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1, IFNA2
266.9HLA-B, HLA-DRB3, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5
276.9HLA-B, HLA-DRB3, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5
28
Show member pathways
6.9HLA-B, HLA-DRB3, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5
296.9HLA-B, HLA-DRB3, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5
30
Show member pathways
6.9HLA-B, HLA-DRB3, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5
316.9HLA-DRB4, HLA-DRB1, HLA-DRB5, HLA-C, HLA-DQB1, HLA-B
32
Show member pathways
6.6HLA-DRB1, IFNA2, HLA-DRB4, HLA-DRB5, HLA-B, HLA-DRB3
33
Show member pathways
6.6HLA-B, HLA-DRB3, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5
34
Show member pathways
6.6HLA-B, HLA-DRB3, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5

Compounds for genes affiliated with Pityriasis Rosea

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Sources:
44Novoseek, 11DrugBank, 50PharmGKB, 2BitterDB, 24HMDB
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Compounds related to Pityriasis Rosea according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1levamisole44 1110.9HLA-A, IFNA2
2dr-10449.8HLA-DRB1, HLA-A
3busulfan44 50 1111.7HLA-B, IFNA2
4dapsone44 2 50 1112.6IFNA2, HLA-B
5ecori449.6HLA-B, HLA-DQB1
62,5-oligoadenylate449.4IFNA2, HLA-B
7carbamazepine44 50 1111.4HLA-A, HLA-B
8allopurinol44 50 1111.3IFNA2, HLA-A, HLA-B
9ursodeoxycholic acid44 24 1111.3HLA-B, HLA-A, IFNA2
10ribavirin44 50 1111.2IFNA2, HLA-B
11histidine449.1HLA-B, HLA-DQB1, IFNA2
12oligonucleotide448.6HLA-DRB1, HLA-DQB1, HLA-A, HLA-B
13tyrosine448.2IFNA2, HLA-DRB1, HLA-DQB1, HLA-A, HLA-B

GO Terms for genes affiliated with Pityriasis Rosea

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Cellular components related to Pityriasis Rosea according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1MHC class I protein complexGO:0426129.2HLA-C, HLA-A, HLA-B
2phagocytic vesicle membraneGO:0306709.1HLA-C, HLA-A, HLA-B
3late endosome membraneGO:0319029.0HLA-DRB3, HLA-DRB5, HLA-DRB4, HLA-DRB1
4early endosome membraneGO:0319018.9HLA-C, HLA-A, HLA-B
5external side of plasma membraneGO:0098978.9HLA-DRB3, HLA-DRB5, HLA-DRB4, HLA-DRB1
6MHC class II protein complexGO:0426138.7HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
7clathrin-coated endocytic vesicle membraneGO:0306698.7HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
8transport vesicle membraneGO:0306588.7HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
9trans-Golgi network membraneGO:0325888.7HLA-DRB1, HLA-DRB4, HLA-DRB5, HLA-DQB1, HLA-DRB3
10endocytic vesicle membraneGO:0306668.7HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
11lysosomal membraneGO:0057658.6HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
12membraneGO:0160208.4HLA-DRB1, HLA-DQB1, HLA-DRB3, HLA-B
13cell surfaceGO:0099868.2HLA-B, HLA-A, HLA-C, CX3CL1
14extracellular vesicular exosomeGO:0700627.9HLA-B, HLA-A, HLA-C, HLA-DRB5, HLA-DRB1
15integral component of plasma membraneGO:0058877.8HLA-B, HLA-DRB3, HLA-A, HLA-C, HLA-DRB4, HLA-DRB1
16ER to Golgi transport vesicle membraneGO:0125077.3HLA-DRB1, HLA-B, HLA-DRB3, HLA-A, HLA-DQB1, HLA-C
17integral component of lumenal side of endoplasmic reticulum membraneGO:0715567.3HLA-B, HLA-DRB3, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5
18Golgi membraneGO:0001397.2HLA-B, HLA-DRB3, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5
19plasma membraneGO:0058866.3HLA-B, HLA-DRB3, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5

Biological processes related to Pityriasis Rosea according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independentGO:0024869.3HLA-B, HLA-A, HLA-C
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:0024809.2HLA-C, HLA-A, HLA-B
3regulation of interleukin-10 secretionGO:20011799.1HLA-DRB3, HLA-DRB5, HLA-DRB4, HLA-DRB1
4regulation of interleukin-4 productionGO:0326739.1HLA-DRB3, HLA-DRB5, HLA-DRB4, HLA-DRB1
5positive regulation of T cell mediated cytotoxicityGO:0019169.1HLA-C, HLA-A, HLA-B
6T-helper 1 type immune responseGO:0420889.1HLA-DRB3, HLA-DRB5, HLA-DRB4, HLA-DRB1
7inflammatory response to antigenic stimulusGO:0024379.1HLA-DRB1, HLA-DRB4, HLA-DRB5, HLA-DRB3
8positive regulation of insulin secretion involved in cellular response to glucose stimulusGO:0357749.1HLA-DRB3, HLA-DRB5, HLA-DRB4, HLA-DRB1
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:0024799.1HLA-B, HLA-A, HLA-C
10negative regulation of interferon-gamma productionGO:0326899.1HLA-DRB1, HLA-DRB4, HLA-DRB5, HLA-DRB3
11protein tetramerizationGO:0512629.0HLA-DRB3, HLA-DRB5, HLA-DRB4, HLA-DRB1
12defense responseGO:0069529.0CX3CL1, HLA-B
13antigen processing and presentation of exogenous peptide antigen via MHC class IGO:0425909.0HLA-C, HLA-A, HLA-B
14negative regulation of T cell proliferationGO:0421309.0HLA-DRB3, HLA-DRB5, HLA-DRB4, HLA-DRB1
15regulation of immune responseGO:0507768.9HLA-B, HLA-A, HLA-C
16type I interferon signaling pathwayGO:0603378.9HLA-B, HLA-A, HLA-C, IFNA2
17humoral immune response mediated by circulating immunoglobulinGO:0024558.8HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
18immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023818.8HLA-DRB1, HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4
19antigen processing and presentation of peptide antigen via MHC class IGO:0024748.7HLA-C, HLA-A, HLA-B
20T cell costimulationGO:0312958.7HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
21T cell receptor signaling pathwayGO:0508528.7HLA-DRB1, HLA-DRB4, HLA-DRB5, HLA-DQB1, HLA-DRB3
22antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198868.7HLA-DRB3, HLA-DQB1, HLA-DRB5, HLA-DRB4, HLA-DRB1
23detection of bacteriumGO:0160458.1HLA-A, HLA-DRB5, HLA-DRB4, HLA-DRB1, HLA-DRB3, HLA-B
24interferon-gamma-mediated signaling pathwayGO:0603337.3HLA-B, HLA-DRB3, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5
25immune responseGO:0069556.5CX3CL1, HLA-B, HLA-DRB3, HLA-A, HLA-DQB1, HLA-C
26cytokine-mediated signaling pathwayGO:0192216.1HLA-DRB3, HLA-A, HLA-DQB1, HLA-C, HLA-DRB5, HLA-DRB4

Molecular functions related to Pityriasis Rosea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1TAP bindingGO:0469778.7HLA-C, HLA-A, HLA-B
2MHC class II receptor activityGO:0323958.6HLA-DRB3, HLA-DQB1, HLA-DRB4, HLA-DRB1
3receptor bindingGO:0051028.2CX3CL1, HLA-C, HLA-A, HLA-B
4peptide antigen bindingGO:0426057.4HLA-DRB1, HLA-DRB4, HLA-DRB5, HLA-C, HLA-A, HLA-DRB3

Products for genes affiliated with Pityriasis Rosea

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Sources for Pityriasis Rosea

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet